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Fear memory

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https://www.readbyqxmd.com/read/29054891/special-issue-on-the-effect-of-fear-and-stress-on-memory
#1
EDITORIAL
Susan Cushman, John H Byrne
No abstract text is available yet for this article.
September 2017: Learning & Memory
https://www.readbyqxmd.com/read/29042636/dysfunctional-early-processing-of-facial-expressions-in-hazardous-drinkers-evidence-from-an-erp-study
#2
Hui Zhang, Yi Jin, John S Y Chan, Feng-Chi Yang, Fang Cui
Chronic alcohol intoxication impairs multiple cognitive functions. According to the dual system model (DSM), the development of alcohol dependence (AD) involves the imbalance between the automatic-affective system and the reflective system. However, the cognitive functions of non-AD hazardous drinkers (HDs) remain unclear. The present study aimed to explore how the HDs process facial expressions differently from the healthy subjects. Sixteen HDs and seventeen control subjects (CSs) completed an emotional working memory (WM) task while the electroencephalogram (EEG) was recorded...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29042315/-interleukin-1-beta-reduces-glua1-phosphorylation-and-its-surface-expression-during-memory-reconsolidation-and-alpha-melanocyte-stimulating-hormone-can-modulate-these-effects
#3
Ivana Machado, Helgi B Schiöth, Mercedes Lasaga, Teresa Scimonelli
Pro-inflammatory cytokines can affect cognitive processes such as learning and memory. Particularly, interleukin-1β (IL-1β) influences hippocampus-dependent memories. We previously reported that administration of IL-1β in dorsal hippocampus impaired contextual fear memory reconsolidation. This effect was reversed by the melanocortin alpha-melanocyte-stimulating hormone (α-MSH). Our results also demonstrated that IL-1β produced a significant decrease in glutamate release from dorsal hippocampus synaptosomes after reactivation of the fear memory...
October 14, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29038220/context-memory-formation-requires-activity-dependent-protein-degradation-in-the-hippocampus
#4
Patrick K Cullen, Nicole C Ferrara, Shane E Pullins, Fred J Helmstetter
Numerous studies have indicated that the consolidation of contextual fear memories supported by an aversive outcome like footshock requires de novo protein synthesis as well as protein degradation mediated by the ubiquitin-proteasome system (UPS). Context memory formed in the absence of an aversive stimulus by simple exposure to a novel environment requires de novo protein synthesis in both the dorsal (dHPC) and ventral (vHPC) hippocampus. However, the role of UPS-mediated protein degradation in the consolidation of context memory in the absence of a strong aversive stimulus has not been investigated...
November 2017: Learning & Memory
https://www.readbyqxmd.com/read/29038217/hippocampal-area-ca1-and-remote-memory-in-rats
#5
Amber C Ocampo, Larry R Squire, Robert E Clark
Hippocampal lesions often produce temporally graded retrograde amnesia (TGRA), whereby recent memory is impaired more than remote memory. This finding has provided support for the process of systems consolidation. However, temporally graded memory impairment has not been observed with the watermaze task, and the findings have been inconsistent with context fear conditioning. One possibility is that large hippocampal lesions indirectly disrupt (by retrograde degeneration) the function of areas that project to the hippocampus that are important for task performance or thought to be important for storing consolidated memories...
November 2017: Learning & Memory
https://www.readbyqxmd.com/read/29030298/linking-muscarinic-receptor-activation-to-ups-mediated-object-memory-destabilization-implications-for-long-term-memory-modification-and-storage
#6
Mikaela L Stiver, Jacob M Cloke, Natalie Nightingale, Julian Rizos, William S Messer, Boyer D Winters
Consolidated memories can become destabilized during reactivation, resulting in a transient state of instability, a process that has been hypothesized to underlie long-term memory updating. Consistent with this notion, relatively remote memories, which are resistant to standard destabilization procedures, are reliably destabilized when novel information (i.e., the opportunity for memory updating) is present during reactivation. We have also shown that cholinergic muscarinic receptor (mAChR) activation can similarly destabilize consolidated object memories...
October 10, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29030297/impaired-extinction-of-cued-fear-memory-and-abnormal-dendritic-morphology-in-the-prelimbic-and-infralimbic-cortices-in-vpac2-receptor-vipr2-deficient-mice
#7
Yukio Ago, Atsuko Hayata-Takano, Takuya Kawanai, Ryosuke Yamauchi, Shuto Takeuchi, Jesse D Cushman, Abha K Rajbhandari, Michael S Fanselow, Hitoshi Hashimoto, James A Waschek
The structurally related neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) have been implicated in stress regulation and learning and memory. Several bodies of research have shown the impact of the PACAP specific receptor PAC1 on fear memory, but the roles of other PACAP receptors in regulating fear stress responses remain to be elucidated. Here we aimed to investigate the effects of genetic deletion of VIPR2 encoding the VPAC2 receptor, which binds both VIP and PACAP, on fear-related memory and on dendritic morphology in the brain regions of the fear circuitry...
October 10, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29029324/cadmium-exposure-impairs-cognition-and-olfactory-memory-in-male-c57bl-6-mice
#8
Hao Wang, Liang Zhang, Glen M Abel, Daniel R Storm, Zhengui Xia
Cadmium (Cd) is a heavy metal of high interest to the Superfund Initiative. Recent epidemiology studies have suggested a possible association between Cd exposure and cognitive as well as olfactory impairments in humans. However, studies in animal models are needed to establish a direct causal relationship between Cd exposure and impairments in cognition and olfaction. This study aims to investigate the toxic effect of Cd on cognition and olfactory function in mice. One group of 8-week old C57BL/6 male mice was exposed to 3 mg/L Cd (in the form of CdCl2) through drinking water for 20 weeks for behavior tests and final blood Cd concentration analysis...
September 25, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29028150/potential-of-micrornas-as-novel-targets-in-the-alleviation-of-pathological-fear
#9
REVIEW
Conor P Murphy, Nicolas Singewald
The current treatment of post-traumatic stress disorder (PTSD), phobias and other anxiety disorders, remains insufficient particularly in producing long-lasting full symptom control. Dysfunctional fear processing is common in these disorders, including a deficiency in fear-inhibitory mechanisms and impairment in the ability to discriminate between safety and danger cues. Research has aimed to elucidate brain circuitries, neurotransmitters and downstream signaling pathways important in the alleviation of aberrant fear, with a specific focus on mechanisms modulating fear memory and its behavioral expression...
October 13, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29025687/serine-racemase-and-d-serine-in-the-amygdala-are-dynamically-involved-in-fear-learning
#10
Darrick T Balu, Kendall Taylor Presti, Cathy C Y Huang, Kevin Muszynski, Inna Radzishevsky, Herman Wolosker, Guia Guffanti, Kerry J Ressler, Joseph T Coyle
BACKGROUND: The amygdala is a central component of the neural circuitry that underlies fear learning. N-methyl-D-aspartate receptor-dependent plasticity in the amygdala is required for pavlovian fear conditioning and extinction. N-methyl-D-aspartate receptor activation requires the binding of a coagonist, D-serine, which is synthesized from L-serine by the neuronal enzyme serine racemase (SR). However, little is known about SR and D-serine function in the amygdala. METHODS: We used immunohistochemical methods to characterize the cellular localization of SR and D-serine in the mouse and human amygdala...
August 26, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29019520/feelings-and-perceptions-of-women-recovering-from-anorexia-nervosa-regarding-their-eating-behavior
#11
Nathalia Petry, Francisco de Assis Guedes de Vasconcelos, Larissa da Cunha Feio Costa
According to the phenomenological approach, observing a phenomenon through the perspective of those who lived it may be necessary to acquire fully comprehension of it. Therefore, to fully understand the eating behavior during anorexia nervosa and during its recovery, this study investigated individual perceptions and feelings of three women recovering from anorexia nervosa. This study is characterized as a qualitative research with phenomenological approach. The data were collected through interviews and analyzed following steps proposed by phenomenology researchers...
October 9, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29017931/acute-nicotine-disrupts-consolidation-of-contextual-fear-extinction-and-alters-long-term-memory-associated-hippocampal-kinase-activity
#12
Munir Gunes Kutlu, Brendan Garrett, Sana Gadiwalla, Jessica M Tumolo, Thomas J Gould
Previous research has shown that acute nicotine, an agonist of nAChRs, impaired fear extinction. However, the effects of acute nicotine on consolidation of contextual fear extinction memories and associated cell signaling cascades are unknown. Therefore, we examined the effects of acute nicotine injections before (pre-extinction) and after (post-extinction) contextual fear extinction on behavior and the phosphorylation of dorsal and ventral hippocampal ERK1/2 and JNK1 and protein levels on the 1st and 3rd day of extinction...
October 7, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29017388/pathophysiological-bases-of-comorbidity-tbi-and-ptsd
#13
Gary B Kaplan, Kimberly A Leite-Morris, Lei Wang, Kendra K Rumbika, Stephen C Heinrichs, Xiang Zeng, Liquan Wu, Danielle T Arena, Yang D Teng
The high rates of TBI and PTSD diagnoses encountered in recent years by the U.S. Veterans Affairs Healthcare System have increased public awareness and research investigation into these conditions. In this review, we analyze the neural mechanisms underlying the TBI/PTSD comorbidity. TBI and PTSD present with common neuropsychiatric symptoms including anxiety, irritability, insomnia, personality changes and memory problems and this overlap complicates diagnostic differentiation. Interestingly, both TBI and PTSD can be produced by overlapping pathophysiological changes that disrupt neural connections termed the "connectome"...
October 10, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29017196/-the-role-of-eye-movement-desensitization-and-reprocessing-emdr-in-substance-use-disorders-a-systematic-review
#14
René Pilz, Riccarda Hartleb, Gabriela Konrad, Eva Reininghaus, Human Friedrich Unterrainer
Eye Movement Desensitization and Reprocessing (EMDR) is a therapeutic method that has been shown to be especially effective in traumatic disorders. Since the concept of an addiction memory has become widely accepted, the use of EMDR also in substance use disorders (SUD) treatment might count as a separate field. This review summarizes the current state of research on treatment effects EMDR in SUD. The literature search included the databases of PubMed and PsychInfo; four studies met the inclusion criteria. EMDR was found to be related to a decreased amount of craving, fear and depression and to an improvement of emotion regulation and management and self-esteem...
October 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/28987617/mitigation-of-postnatal-ethanol-induced-neuroinflammation-ameliorates-trace-fear-memory-deficits-in-juvenile-rats
#15
Molly J Goodfellow, Youn Ju Shin, Derick H Lindquist
Impairments in behavior and cognition are common in individuals diagnosed with fetal alcohol spectrum disorders (FASD). In this study, FASD model rats were intragastrically intubated with ethanol (5g/kg/day; 5E), sham-intubated (SI), or maintained as naïve controls (NC) over postnatal days (PD) 4-9. Ethanol exposure during this human third trimester-equivalent period induces persistent impairments in hippocampus-dependent learning and memory. The ability of ibuprofen (IBU), a non-steroidal anti-inflammatory drug, to diminish ethanol-induced neuroinflammation and rescue deficits in hippocampus-dependent trace fear conditioning (TFC) was investigated in 5E rats...
October 5, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28987515/does-exercise-augment-operant-and-pavlovian-extinction-a-meta-analysis
#16
Rheall F Roquet, Marie-H Monfils
BACKGROUND: Exposure therapy, a behavioral approach to reduce symptomology in fear, anxiety, and drug-related psychiatric disorders, is based on learning and memory principles of extinction, and is subject to relapse. As such, it is important to find ways to enhance outcomes. One such way is through exercise. OBJECTIVES: Identify if exercise augments extinction behavior, and whether this depends on the experimental paradigm used (i.e. operant or Pavlovian) and/or stimulus (i...
September 20, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28981869/overexpression-of-neuregulin-1-type-iii-confers-hippocampal-mrna-alterations-and-schizophrenia-like-behaviors-in-mice
#17
Juan C Olaya, Carrie L Heusner, Mitsuyuki Matsumoto, Duncan Sinclair, Mari A Kondo, Tim Karl, Cynthia Shannon Weickert
Neuregulin 1 (NRG1) is a schizophrenia candidate gene whose protein product is involved in neuronal migration, survival, and synaptic plasticity via production of specific isoforms. Importantly, NRG1 type III (NRG1 III) mRNA is increased in humans inheriting a schizophrenia risk haplotype for the NRG1 gene (HapICE), and NRG1 protein levels can be elevated in schizophrenia. The nature by which NRG1 type III overexpression results in schizophrenia-like behavior and brain pathology remains unclear, therefore we constructed a transgenic mouse with Nrg1 III overexpression in forebrain neurons (CamKII kinase+)...
September 8, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28978762/layer-and-subregion-specific-differences-in-the-neurophysiological-properties-of-rat-medial-prefrontal-cortex-pyramidal-neurons
#18
Chenghui Song, James R Moyer
Medial prefrontal cortex (mPFC) is critical for the expression of long term conditioned fear. However, the neural circuits involving fear memory acquisition and retrieval are still unclear. Two subregions within mPFC that have received a lot of attention are the prelimbic (PL) and infralimbic (IL) cortices (e.g., Santini et al. 2008; Song et al. 2015). Interestingly, PL and IL may play distinct roles during fear memory acquisition and retrieval but the underlying mechanism is poorly understood. One possibility is that the intrinsic membrane properties differ between these subregions...
October 4, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28976945/activation-of-nigrostriatal-dopamine-neurons-during-fear-extinction-prevents-the-renewal-of-fear
#19
Courtney A Bouchet, Megan A Miner, Esteban C Loetz, Adam J Rosberg, Holly S Hake, Caroline E Farmer, Mykola Ostrovskyy, Nathan Gray, Benjamin N Greenwood
Manipulations that increase dopamine (DA) signaling can enhance fear extinction, but the circuits involved remain unknown. DA neurons originating in the substantia nigra (SN) projecting to the dorsal striatum (DS) are traditionally viewed in the context of motor behavior, but growing data implicate this nigrostriatal circuit in emotion. Here we investigated the role of nigrostriatal DA in fear extinction. Activation of SN DA neurons with designer Gq-coupled receptors exclusively activated by designer drugs (Gq-DREADD) during fear extinction had no effect on fear extinction acquisition, but enhanced fear extinction memory and blocked the renewal of fear in a novel context; a pattern of data paralleled by cFos expression in the central amygdala...
October 4, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28968688/mir-181a-participates-in-contextual-fear-memory-formation-via-activating-mtor-signaling-pathway
#20
Xu-Feng Xu, Xu Jing, Hui-Xian Ma, Rong-Rong Yuan, Qing Dong, Jun-Lu Dong, Xiao-Fei Han, Zhe-Yu Chen, Xiang-Zhi Li, Yue Wang
Long-term memory formation has been proven to require gene expression and new protein synthesis. MicroRNAs (miRNAs), as an endogenous small non-coding RNAs, inhibit the expression of their mRNA targets, through which involve in new memory formation. In this study, elevated miR-181a levels were found to be responsible for hippocampal contextual fear memory consolidation. Using a luciferase reporter assay, we indicated that miR-181a targets 2 upstream molecules of mTOR pathway, namely, PRKAA1 and REDD1. Upregulated miR-181a can downregulate the PRKAA1 and REDD1 protein levels and promote mTOR activity to facilitate hippocampal fear memory consolidation...
August 22, 2017: Cerebral Cortex
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