keyword
MENU ▼
Read by QxMD icon Read
search

Fear memory

keyword
https://www.readbyqxmd.com/read/29444449/dendritic-spine-density-and-ephrinb2-levels-of-hippocampal-and-anterior-cingulate-cortex-neurons-increase-sequentially-during-formation-of-recent-and-remote-fear-memory-in-the-mouse
#1
Georgia Abate, Sandra Colazingari, Alessandra Accoto, David Conversi, Arturo Bevilacqua
Memory consolidation is a dynamic process that involves a sequential remodeling of hippocampal-cortical circuits. Although synaptic events underlying memory consolidation are well assessed, fine molecular events controlling this process deserve further characterization. To this aim, we challenged male C57BL/6N mice in a contextual fear conditioning (CFC) paradigm and tested their memory 24 h, 7 days or 36 days later. Mice displayed a strong fear response at all time points with an increase in dendritic spine density and protein levels of the cell adhesion factor EphrinB2 in CA1 hippocampal neurons 24 h and 7 days post conditioning (p...
February 11, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29432803/learning-and-memory-is-modulated-by-cannabidiol-when-administered-during-trace-fear-conditioning
#2
A L Uhernik, Z T Montoya, C D Balkissoon, J P Smith
Cannabidiol (CBD) is thought to have therapeutic potential for treating psychiatric conditions that affect cognitive aspects of learning and memory, including anxiety and post-traumatic stress disorder (PTSD). Studies have shown that CBD enhances extinction of fear memory when given after conditioning. This led us to hypothesize that CBD, if administered prior to fear conditioning, might modulate cognitive learning and memory processes in additional ways that would further guide its potential use for treating PTSD...
February 9, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29432797/ethological-and-multi-behavioral-analysis-of-learning-and-memory-performance-in-laboratory-rodent-models
#3
REVIEW
Hiroyuki Arakawa, Yoshio Iguchi
Behavioral studies using animal models have widely contributed to advancing our understanding of the neuroregulatory mechanisms of human cognitive states and disorders. A variety of behavioral tests and theoretical models have been developed that provide a standardized toolbox of behavioral test paradigms available to researchers, and thus allow rapid progress in studies of the molecular-genetic bases of behavior relevant to neurocognitive diseases. However, a growing effort to utilize standardized paradigms has overlooked the diverse behavioral characteristics of test rodents expressed in standardized test situations...
February 9, 2018: Neuroscience Research
https://www.readbyqxmd.com/read/29431646/basolateral-amygdala-inputs-to-the-medial-entorhinal-cortex-selectively-modulate-the-consolidation-of-spatial-and-contextual-learning
#4
Krista L Wahlstrom, Mary L Huff, Eric B Emmons, John H Freeman, Nandakumar S Narayanan, Christa K McIntyre, Ryan T LaLumiere
Although evidence suggests that the basolateral amygdala (BLA) and dorsal hippocampus (DH) work together to influence the consolidation of spatial/contextual learning, the circuit mechanism by which the BLA selectively modulates spatial/contextual memory consolidation is not clear. The medial entorhinal cortex (mEC) is a critical region in the hippocampus-based system for processing spatial information. As an efferent target of the BLA, the mEC is a candidate by which the BLA influences the consolidation of such learning...
February 5, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29425501/homeostatic-plasticity-in-the-hippocampus-facilitates-memory-extinction
#5
Pablo Mendez, Thomas Stefanelli, Carmen E Flores, Dominique Muller, Christian Lüscher
Correlated activity in the hippocampus drives synaptic plasticity that is necessary for the recruitment of neuronal ensembles underlying fear memory. Sustained neural activity, on the other hand, may trigger homeostatic adaptations. However, whether homeostatic plasticity affects memory function remains unknown. Here, we use optogenetics to induce cell autonomous homeostatic plasticity in CA1 pyramidal neurons and granule cells of the hippocampus. High-frequency spike trains applied for 10 min decreased the number of excitatory spine synapses and increased the number of inhibitory shaft synapses...
February 6, 2018: Cell Reports
https://www.readbyqxmd.com/read/29422905/immunomodulatory-properties-of-carvone-inhalation-and-its-effects-on-contextual-fear-memory-in-mice
#6
Aritz Lasarte-Cia, Teresa Lozano, Marta Pérez-González, Marta Gorraiz, Kristina Iribarren, Sandra Hervás-Stubbs, Pablo Sarobe, Obdulia Rabal, Mar Cuadrado-Tejedor, Ana García-Osta, Noelia Casares, Juan José Lasarte
A complex network of interactions exists between the immune, the olfactory, and the central nervous system (CNS). Inhalation of different fragrances can affect immunological reactions in response to an antigen but also may have effects on the CNS and cognitive activity. We performed an exploratory study of the immunomodulatory ability of a series of compounds representing each of the 10 odor categories or clusters described previously. We evaluated the impact of each particular odor on the immune response after immunization with the model antigen ovalbumin in combination with the TLR3 agonist poly I:C...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29422138/roles-of-the-anterior-basolateral-amygdalar-nucleus-during-exposure-to-a-live-predator-and-to-a-predator-associated-context
#7
Ricardo Passoni Bindi, Marcus Vinicius C Baldo, Newton Sabino Canteras
The basolateral amygdala complex, which includes the lateral, basolateral and basomedial nuclei, has been implicated in innate and contextual fear responses to predator threats. In the basolateral complex, the lateral and posterior basomedial nuclei are able to process predator odor information, and they project to the predator-responsive hypothalamic circuit; lesions in these amygdalar sites reduce innate responses and practically abolish contextual fear responses to predatory threats. In contrast to the lateral and posterior basomedial nuclei, the basolateral nucleus does not receive direct information from predator olfactory cues and has no direct link to the predator-responsive hypothalamic circuit...
April 16, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29421611/gpr30-activation-improves-memory-and-facilitates-dhpg-induced-ltd-in-the-hippocampal-ca3-of-middle-aged-mice
#8
Wen Xu, Jian Cao, Yan Zhou, Lina Wang, Guoqi Zhu
Reduced estrogen levels and decreased expression of related receptors are typical cerebral features of aging. The G protein-coupled estrogen receptor 1 (GPER1, also known as GPR30) is considered a novel therapeutic target for neurodegenerative diseases. In this study, we demonstrated that hippocampal GPR30 expression was reduced in middle-aged mice compared with young adult mice. GPR30 agonist G1 improved both fear and spatial memory in both male and female middle-aged mice, but not in young adult mice, which were blocked by the GPR30 antagonist G15...
February 5, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29412144/early-life-stress-determines-the-effects-of-glucocorticoids-and-stress-on-hippocampal-function-electrophysiological-and-behavioral-evidence-respectively
#9
Anup G Pillai, Marit Arp, Els Velzing, Sylvie L Lesuis, Mathias V Schmidt, Florian Holsboer, Marian Joëls, Harm J Krugers
Exposure to early-life adversity may program brain function to prepare individuals for adaptation to matching environmental contexts. In this study we tested this hypothesis in more detail by examining the effects of early-life stress - induced by raising offspring with limited nesting and bedding material from postnatal days 2-9 - in various behavioral tasks and on synaptic function in adult mice. Early-life stress impaired adult performance in the hippocampal dependent low-arousing object-in-context recognition memory task...
February 2, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29411941/preserved-re-experience-of-discrete-emotions-amnesia-and-executive-function
#10
Marian Andrei Stanciu, Robert D Rafal, Oliver H Turnbull
Amnesic patients can re-experience emotions elicited by forgotten events, suggesting that brain systems for episodic and emotional memory are independent. However, the range of such emotional memories remains under-investigated (most studies employing just positive-negative emotion dyads), and executive function may also play a role in the re-experience of emotions. This is the first investigation of the intensity of the emotional re-experience of a range of discrete emotions (anger, fear, sadness, and happiness) for a group of amnesic patients...
February 7, 2018: Journal of Neuropsychology
https://www.readbyqxmd.com/read/29408468/neuropeptide-y2-receptors-in-anteroventral-bnst-control-remote-fear-memory-depending-on-extinction-training
#11
Dilip Verma, Ramon Tasan, Guenther Sperk, Hans-Christian Pape
The anterior bed nucleus of stria terminalis (BNST) is involved in reinstatement of extinguished fear, and neuropeptide Y2 receptors influence local synaptic signaling. Therefore, we hypothesized that Y2 receptors in anteroventral BNST (BNSTav) interfere with remote fear memory and that previous fear extinction is an important variable. C57BL/6NCrl mice were fear-conditioned, and a Y2 receptor-specific agonist (NPY3-36) or antagonist (JNJ-5207787) was applied in BNSTav before fear retrieval at the following day...
February 2, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29408273/impairment-in-extinction-of-cued-fear-memory-in-syntenin-1-knockout-mice
#12
Gourango Talukdar, Ran Inoue, Tomoyuki Yoshida, Hisashi Mori
Syntenin-1 is a PDZ domain-containing intracellular scaffold protein involved in exosome production, synapse formation, and synaptic plasticity. We tested whether syntenin-1 can regulate learning and memory through its effects on synaptic plasticity. Specifically, we investigated the role of syntenin-1 in contextual and cued fear conditioning and extinction of conditioned fear using syntenin-1 knockout (KO) mice. Genetic disruption of syntenin-1 had little effect on contextual and cued fear memory. However, syntenin-1 KO mice exhibited selective impairment in cued fear extinction retention...
February 3, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29403033/hippocampus-driven-feed-forward-inhibition-of-the-prefrontal-cortex-mediates-relapse-of-extinguished-fear
#13
Roger Marek, Jingji Jin, Travis D Goode, Thomas F Giustino, Qian Wang, Gillian M Acca, Roopashri Holehonnur, Jonathan E Ploski, Paul J Fitzgerald, Timothy Lynagh, Joseph W Lynch, Stephen Maren, Pankaj Sah
The medial prefrontal cortex (mPFC) has been implicated in the extinction of emotional memories, including conditioned fear. We found that ventral hippocampal (vHPC) projections to the infralimbic (IL) cortex recruited parvalbumin-expressing interneurons to counter the expression of extinguished fear and promote fear relapse. Whole-cell recordings ex vivo revealed that optogenetic activation of vHPC input to amygdala-projecting pyramidal neurons in the IL was dominated by feed-forward inhibition. Selectively silencing parvalbumin-expressing, but not somatostatin-expressing, interneurons in the IL eliminated vHPC-mediated inhibition...
February 5, 2018: Nature Neuroscience
https://www.readbyqxmd.com/read/29400641/diagnosis-makes-a-difference-perceptions-of-older-persons-with-dementia-symptoms
#14
Jed A Diekfuss, Jessica De Larwelle, Susan H McFadden
Background/Study Context: Employing the stereotype content model and terror management theory, we examined whether stereotypes and feelings about persons with dementia vary depending on the type of dementia diagnosis and purported causes of the dementia. METHODS: Participants were randomly assigned to read one of four vignettes that depicted a man who consulted his doctor because of memory problems. All vignettes described the same symptoms and diagnostic tests, but each of four groups read a different result: all tests normal (Normal); Alzheimer's disease (AD); Wernicke-Korsakoff Syndrome (WKS) associated with alcohol abuse; and chronic traumatic encephalopathy (CTE) associated with head injuries from playing football in high school and college...
February 5, 2018: Experimental Aging Research
https://www.readbyqxmd.com/read/29398914/-low-road-to-rehabilitation-a-perspective-on-subliminal-sensory-neuroprosthetics
#15
Shashank Ghai, Ishan Ghai, Alfred O Effenberg
Fear can propagate parallelly through both cortical and subcortical pathways. It can instigate memory consolidation habitually and might allow internal simulation of movements independent of the cortical structures. This perspective suggests delivery of subliminal, aversive and kinematic audiovisual stimuli via neuroprosthetics in patients with neocortical dysfunctions. We suggest possible scenarios by which these stimuli might bypass damaged neocortical structures and possibly assisting in motor relearning...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29397508/alteration-of-adaptive-behaviors-of-progeny-after-maternal-mobile-phone-exposure
#16
Nicolas Petitdant, Anthony Lecomte, Franck Robidel, Christelle Gamez, Kelly Blazy, Anne-Sophie Villégier
Exposure of pregnant women to radiofrequency (RF) devices raises questions on their possible health consequences for their progeny. We examined the hazard threshold of gestational RF on the progeny's glial homeostasis, sensory-motor gating, emotionality, and novelty seeking and tested whether maternal immune activation would increase RF toxicity. Pregnant dams were daily restrained with loop antennas adjoining the abdomen (fetus body specific absorption rates (SAR): 0, 0.7, or 2.6 W/kg) and received three lipopolysaccharide (LPS) intra-peritoneal injections (0 or 80 μg/kg)...
February 3, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29397273/anxiety-cells-in-a-hippocampal-hypothalamic-circuit
#17
Jessica C Jimenez, Katy Su, Alexander R Goldberg, Victor M Luna, Jeremy S Biane, Gokhan Ordek, Pengcheng Zhou, Samantha K Ong, Matthew A Wright, Larry Zweifel, Liam Paninski, René Hen, Mazen A Kheirbek
The hippocampus is traditionally thought to transmit contextual information to limbic structures where it acquires valence. Using freely moving calcium imaging and optogenetics, we show that while the dorsal CA1 subregion of the hippocampus is enriched in place cells, ventral CA1 (vCA1) is enriched in anxiety cells that are activated by anxiogenic environments and required for avoidance behavior. Imaging cells defined by their projection target revealed that anxiety cells were enriched in the vCA1 population projecting to the lateral hypothalamic area (LHA) but not to the basal amygdala (BA)...
January 30, 2018: Neuron
https://www.readbyqxmd.com/read/29395984/sleep-and-emotional-processing
#18
REVIEW
Daniela Tempesta, Valentina Socci, Luigi De Gennaro, Michele Ferrara
A growing body of literature suggests that sleep plays a critical role in emotional processing. This review aims at synthesizing current evidence on the role of sleep and sleep loss in the modulation of emotional reactivity, emotional memory formation, empathic behavior, fear conditioning, threat generalization and extinction memory. Behavioral and neurophysiological evidence suggesting that rapid-eye movement (REM) sleep plays an important role in emotional processing is also discussed. Furthermore, we examine the relations between sleep and emotions by reviewing the functional neuroimaging studies that elucidated the brain mechanisms underlying these relations...
December 22, 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29393172/saccular-impairment-in-alzheimer-s-disease-is-associated-with-driving-difficulty
#19
Eric X Wei, Esther S Oh, Aisha Harun, Matthew Ehrenburg, Yuri Agrawal
BACKGROUND/AIMS: Patients with Alzheimer's disease (AD) experience increased rates of vestibular loss. Recent studies suggest that saccular impairment in mild cognitive impairment (MCI) and AD patients is associated with impaired spatial cognitive function. However, the impact of saccular impairment on everyday behaviors that rely on spatial cognitive function is unknown. METHODS: We recruited 60 patients (21 MCI and 39 AD) from an interdisciplinary Memory Clinic...
January 26, 2018: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/29392236/impact-of-patient-information-leaflets-on-pain-medication-intake-behavior-a-pilot-study
#20
Julia Schmitz, Sandra Kamping, Janine Wiegratz, Maike Müller, Jan Stork, Luana Colloca, Herta Flor, Regine Klinger
Introduction: Patient information leaflets on pain medication primarily list side effects while positive effects and action mechanisms remain underrepresented. Nocebo research has shown that negative instructions can lower analgesic effects. Objectives: Research on information leaflets and their influence on mood, memory of side effects, and intake behavior of healthy participants is needed. Methods: To determine the ratio of positive to negative phrases, 18 information leaflets of common, over-the-market analgesics were examined of which 1 was selected...
November 2017: Pain Reports (Baltimore, Md.)
keyword
keyword
25598
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"