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Peritoneal carcinomatosis

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https://www.readbyqxmd.com/read/28538365/cytoreductive-surgery-with-hyperthermic-intraperitoneal-chemotherapy-for-appendiceal-and-colorectal-cancer-with-peritoneal-carcinomatosis-clinical-outcomes-at-2-tertiary-referral-centers-in-korea
#1
Eun Jung Park, Seung Hyuk Baik, Hyuk Hur, Byung Soh Min, Jeonghyun Kang, Yun Dae Han, Min Soo Cho, Kang Young Lee, Nam Kyu Kim
Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is regarded as effective surgical treatments in patients with peritoneal metastasis. This study aimed to evaluate the clinical outcomes of CRS and HIPEC in patients with appendiceal or colorectal cancer with peritoneal carcinomatosis.A total of 66 patients who underwent CRS with HIPEC for appendiceal or colorectal cancer with peritoneal metastasis at 2 tertiary referral centers in Korea were evaluated between July 2014 and March 2016...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28533646/image-findings-of-rare-case-of-peritoneal-carcinomatosis-from-non-small-cell-lung-cancer-and-response-to-erlotinib-in-f-18-fdg-positron-emission-tomography-computed-tomography
#2
Koramadai Karuppusamy Kamaleshwaran, Jephy Joseph, Radha Krishnan Kalarikal, Ajit Sugunan Shinto
Lung cancer is currently one of the most common malignancies in the world. Metastatic disease is observed in ~ 40% of patients with lung cancer, with the most common sites of metastasis being the bone, liver, brain and adrenal glands. Peritoneal carcinomatosis (PC) is defined as the progression of the primary cancer to the peritoneum. PC is a rare clinical event in lung cancer. Tyrosine kinase inhibitors targeting the epidermal growth factor receptor (EGFR), such as erlotinib are used for the treatment of patients with advanced non-small cell lung cancer (NSCLC)...
April 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28529748/local-modulated-electro-hyperthermia-in-combination-with-traditional-chinese-medicine-vs-intraperitoneal-chemoinfusion-for-the-treatment-of-peritoneal-carcinomatosis-with-malignant-ascites-a-phase-ii-randomized-trial
#3
Clifford L K Pang, Xinting Zhang, Zhen Wang, Junwen Ou, Yimin Lu, Pengfei Chen, Changlin Zhao, Xiaopu Wang, Hongyu Zhang, Sergey V Roussakow
The purpose of this study was to develop a safe and non-toxic alternative to the conventional conservative treatment of peritoneal carcinomatosis with malignant ascites (PCMA) by investigating the efficacy and safety of local modulated electro-hyperthermia (mEHT) combined with the traditional Chinese medicine (TCM) 'Shi Pi' herbal decoction, compared with standard intraperitoneal chemoinfusion (IPCI). A randomized, controlled, single-center, open-label clinical trial (phase II) with two parallel groups (allocation ratio, 1:1) was conducted to investigate the efficacy and safety of mEHT+TCM (study group, SG) vs...
May 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28514739/cytoreductive-surgery-plus-hyperthermic-intraperitoneal-chemotherapy-improves-survival-for-peritoneal-carcinomatosis-from-colorectal-cancer-a-systematic-review-and-meta-analysis-of-current-evidence
#4
REVIEW
Chao-Qun Huang, Yao Min, Shu-Yi Wang, Xiao-Jun Yang, Yang Liu, Bin Xiong, Yutaka Yonemura, Yan Li
Objectives The therapeutic efficacy of cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with peritoneal carcinomatosis (PC) from colorectal cancer (CRC) is still under debate. This meta-analysis and systematic review of published literature on this comprehensive strategy aims to evaluate its efficacy on CRC patients with PC.Methods A systemic review with meta-analysis of published literatures on treatment of CRS plus HIPEC for patients with PC from CRC was performed...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28512763/impact-of-mlh1-expression-on-tumour-evolution-after-curative-surgical-tumour-resection-in-a-murine-orthotopic-xenograft-model-for-human-msi-colon-cancer
#5
Katy Meunier, Marianne Ferron, Claire Calmel, Jean-François Fléjou, Marc Pocard, Françoise Praz
Colorectal cancers (CRCs) displaying microsatellite instability (MSI) most often result from MLH1 deficiency. The aim of this study was to assess the impact of MLH1 expression per se on tumour evolution after curative surgical resection using a xenograft tumour model. Transplantable tumours established with the human MLH1-deficient HCT116 cell line and its MLH1-complemented isogenic clone, mlh1-3, were implanted onto the caecum of NOD/SCID mice. Curative surgical resection was performed at day 10 in half of the animals...
May 16, 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/28511234/indications-results-and-clinical-impact-of-endoscopic-ultrasound-eus-guided-sampling-in-gastroenterology-european-society-of-gastrointestinal-endoscopy-esge-clinical-guideline-updated-january-2017
#6
Jean-Marc Dumonceau, Pierre H Deprez, Christian Jenssen, Julio Iglesias-Garcia, Alberto Larghi, Geoffroy Vanbiervliet, Guruprasad P Aithal, Paolo G Arcidiacono, Pedro Bastos, Silvia Carrara, László Czakó, Gloria Fernández-Esparrach, Paul Fockens, Àngels Ginès, Roald F Havre, Cesare Hassan, Peter Vilmann, Jeanin E van Hooft, Marcin Polkowski
For pancreatic solid lesions, ESGE recommends performing endoscopic ultrasound (EUS)-guided sampling as first-line procedure when a pathological diagnosis is required. Alternatively, percutaneous sampling may be considered in metastatic disease.Strong recommendation, moderate quality evidence.In the case of negative or inconclusive results and a high degree of suspicion of malignant disease, ESGE suggests re-evaluating the pathology slides, repeating EUS-guided sampling, or surgery.Weak recommendation, low quality evidence...
May 16, 2017: Endoscopy
https://www.readbyqxmd.com/read/28503333/peritoneal-keratin-granulomatosis-associated-with-endometrioid-adenocarcinoma-of-the-uterine-corpus-in-a-woman-with-polycystic-ovaries-a-potential-pitfall-a-case-report-and-review-of-the-literature
#7
Helen J Trihia, Maria Papazian, Natasa Novkovic, John Provatas, Sotiria Tsangouri, Dimitrios C Papatheodorou
Peritoneal keratin granulomatosis is a rare condition included under granulomatous lesions of the peritoneum. It can be secondary to neoplasms of the female genital tract and can mimic carcinomatosis intraoperatively. A case of a 40-year-old woman with a history of polycystic ovaries and a chief complaint of vaginal bleeding is presented. She was diagnosed with endometrioid adenocarcinoma with squamous differentiation in endometrial curettings. Intraoperatively, many peritoneal nodules were found, interpreted as peritoneal carcinomatosis...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28501555/antitumor-effect-of-azd4547-in-a-fibroblast-growth-factor-receptor-2-amplified-gastric-cancer-patient-derived-cell-model
#8
Jiryeon Jang, Hee Kyung Kim, Heejin Bang, Seung Tae Kim, Sun Young Kim, Se Hoon Park, Ho Yeong Lim, Won Ki Kang, Jeeyun Lee, Kyoung-Mee Kim
BACKGROUND: FGFR2 amplification is associated with aggressive gastric cancer (GC), and targeted drugs have been developed for treatment of GC. We evaluated the antitumor activity of an FGFR inhibitor in FGFR2-amplified GC patients with peritoneal carcinomatosis. METHODS: Two GC patients with FGFR2 amplification confirmed by fluorescence in situ hybridization showed peritoneal seeding and malignant ascites. We used the patient-derived xenograft model; patient-derived cells (PDCs) from malignant ascites were used to assess FGFR2 expression and its downstream pathway using immunofluorescence analysis and immunoblot assay in vitro...
May 10, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28501254/cytoreduction-and-hyperthermic-intraperitoneal-chemotherapy-in-the-management-of-colorectal-peritoneal-metastasis
#9
REVIEW
Bradley Hall, James Padussis, Jason M Foster
Historically, patients with peritoneal carcinomatosis secondary to colorectal cancer have a poor overall prognosis. Recent data support the use of cytoreductive surgery and heated intraperitoneal chemotherapy (CRS + HIPEC) to specifically address the peritoneal disease. Retrospective studies on CRS + HIPEC have been promising, showing significant improvements in OS compared with systemic chemotherapy alone. However, CRS + HIPEC carries morbidity similar to other advance oncology procedures such as liver resection and pancreatoduonectomy...
June 2017: Surgical Clinics of North America
https://www.readbyqxmd.com/read/28501134/factors-associated-with-palliative-care-use-in-patients-undergoing-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#10
Rachel S Morris, Faiz Gani, Abdulrahman Y Hammad, Wendy Peltier, T Clark Gamblin, Kiran K Turaga, Fabian M Johnston
BACKGROUND: Peritoneal carcinomatosis represents widespread metastatic disease throughout the abdomen and/or pelvis. Cytoreductive surgery/hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) improves the overall survival compared to standard therapy alone. The role palliative care (PC) plays however, remains poorly studied among these patients. METHODS: Patients who had previously undergone HIPEC and who underwent an inpatient admission from 7/1/2013 to 6/30/2014 were identified to determine which patients were referred for inpatient or outpatient palliative consultation...
May 1, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28487593/ovarian-carcinomatosis-in-a-dog-managed-with-surgery-and-intraperitoneal-systemic-and-intrapleural-chemotherapy-utilizing-indwelling-pleural-access-ports
#11
Matthew P Best, Angela E Frimberger
A 3-year-old Weimaraner dog was presented with bilateral papillary ovarian carcinoma and abdominal carcinomatosis. Treatment included ovariectomy, intraperitoneal cisplatin, and systemic carboplatin. Pleural carcinomatosis 473 days following surgery was treated with intrapleural cisplatin through indwelling pleural access ports. Euthanasia occurred 1154 days following surgery due to malignant pleural effusion without peritoneal effusion.
May 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/28483269/multiplex-profiling-identifies-distinct-local-and-systemic-alterations-during-intraperitoneal-chemotherapy-for-ovarian-cancer-an-nrg-oncology-gynecologic-oncology-group-study
#12
Shannon Grabosch, George Tseng, Robert P Edwards, Heather A Lankes, Kathleen Moore, Kunle Odunsi, Anda Vlad, Tianzhou Ma, Mary Strange, Joan Brozick, Amit Lugade, Angela Omilian, Wiam Bshara, Ashley R Stuckey, Joan L Walker, Michael Birrer
OBJECTIVES: Ovarian cancer leads to abdominal carcinomatosis and late stage (III/IV) diagnosis in 75% of patients. Three randomized phase III trials have demonstrated that intraperitoneal (IP) chemotherapy improves outcomes in epithelial ovarian cancer. While IP treatment is validated by clinical trials, there is a poor understanding of the mechanism(s) leading to the survival advantage other than the increased concentration of cytotoxic drugs within the tumor microenvironment. A better understanding of this process through analysis of dynamic biomarkers should promote novel approaches that may enhance tumor clearance...
May 5, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28470670/chronic-peritoneal-inflammation-and-nodules-masquerading-as-peritoneal-carcinomatosis-in-birt-hogg-dube-syndrome
#13
Jonathan Kam, Yuigi Yuminaga, Mark Louie-Johnsun
No abstract text is available yet for this article.
May 3, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28468593/hyaluronan-binding-peptide-for-targeting-peritoneal-carcinomatosis
#14
Hideki Ikemoto, Prakash Lingasamy, Anne-Mari Anton Willmore, Hedi Hunt, Kaarel Kurm, Olav Tammik, Pablo Scodeller, Lorena Simón-Gracia, Venkata Ramana Kotamraju, Andrew M Lowy, Kazuki N Sugahara, Tambet Teesalu
Peritoneal carcinomatosis results from dissemination of solid tumors in the peritoneal cavity, and is a common site of metastasis in patients with carcinomas of gastrointestinal or gynecological origin. Peritoneal carcinomatosis treatment is challenging as poorly vascularized, disseminated peritoneal micro-tumors are shielded from systemic anticancer drugs and drive tumor regrowth. Here, we describe the identification and validation of a tumor homing peptide CKRDLSRRC (IP3), which upon intraperitoneal administration delivers payloads to peritoneal metastases...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28463674/a-rare-type-of-colorectal-cancer-mixed-adeno-neuroendocrine-carcinoma-manec
#15
Floryn Cherbanyk, Jean Loup Gassend, Maria Dimitrief, Snezana Andrejevic-Blant, Olivier Martinet, Edgardo Pezzetta
The aim of this paper is to report the clinicopathological data of one case of mixed metastatic adenoneuroendocrine carcinoma (MANEC) in the caecum; less than ten cases of which have been described in the English literature. A 57-year-old male patient presented with a mixed adenoneuroendocrine carcinoma (MANEC) of the caecum with liver metastasis and peritoneal carcinomatosis. An emergency right hemicolectomy and omentectomy were performed, followed by several cycles of unsuccessful palliative chemotherapy...
March 2017: Chirurgia
https://www.readbyqxmd.com/read/28461178/four-surgical-approaches-to-cervical-excision-during-laparoscopic-radical-trachelectomy-for-early-cervical-cancer
#16
José Saadi, Lucas Minig, Florencia Noll, Gabriel Saraniti, José Miguel Cárdenas-Rebollo, Myriam Perrotta
A retrospective analysis was performed at the Gynecology Department of the Hospital Italiano de Buenos Aires in Buenos Aires, Argentina to compare clinical and oncologic outcomes of four different surgical approaches of cervical excision (CE) during radical trachelectomy (RT) for early cervical cancer. The study included 22 consecutive women who had undergone laparoscopic RT for early cervical cancer between May 2011 and July 2016 in our tertiary care hospital. Patients were divided into four groups according to their respective tumor pathologies and surgical approaches...
April 28, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28459372/laparoscopic-subperitoneal-injection-of-chemo-loaded-particles-lowers-tumor-growth-on-a-rabbit-model-of-peritoneal-carcinomatosis
#17
Florentina Pascale, Afshin Fazel, Julien Namur, Saida-Homayra Ghegediban, Hadrian D'Inca, Michel Wassef, Laurence Moine, Alexandre Laurent
The purpose of our study was to assess the effect of controlled-release chemotherapy on the growth and viability of peritoneal carcinomatosis treated by subperitoneal injection in a rabbit VX2 model. A model of peritoneal carcinomatosis was created by laparoscopic injection of VX2 tumor in the left and right broad ligaments of 12 White New Zealand rabbits. At day 12, each tumor was randomly treated with a peritumoral injection of 0.5 mL microspheres loaded with doxorubicin (DEM-DOX) or unloaded (DEM-BLAND)...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28456089/the-30-year-experience-a-meta-analysis-of-randomised-and-high-quality-non-randomised-studies-of-hyperthermic-intraperitoneal-chemotherapy%C3%A2-in-the-treatment-of-gastric-cancer
#18
REVIEW
Jacopo Desiderio, Joseph Chao, Laleh Melstrom, Susanne Warner, Federico Tozzi, Yuman Fong, Amilcare Parisi, Yanghee Woo
IMPORTANCE: Hyperthermic intraperitoneal chemotherapy (HIPEC) has been used within various multimodality strategies for the prevention and treatment of gastric cancer peritoneal carcinomatosis. OBJECTIVE: To systematically evaluate the role of HIPEC in gastric cancer and clarify its effectiveness at different stages of peritoneal disease progression. DATA SOURCES: Medline and Embase databases between January 1, 1985 and June 1, 2016. STUDY SELECTION: Randomised control trials and high-quality non-randomised control trials selected on a validated tool (methodological index for non-randomised studies) comparing HIPEC and standard oncological management for the treatment of advanced stage gastric cancer with and without peritoneal carcinomatosis were considered...
April 26, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28442420/eggerthella-lenta-bacteremia-in-solid-tumor-cancer-patients-pathogen-or-witness-of-frailty
#19
Paul-Louis Woerther, Sami Antoun, Elisabeth Chachaty, Mansouria Merad
Eggerthella lenta is increasingly found in patients with severe comorbidities. Because oncologic patients are exposed to emerging pathogens, we aimed to describe the factors associated with E. lenta bacteremia in this immunosuppressed population. Oncology patients with blood cultures positive for E. lenta were retrospectively recorded from 2009 to 2015. Socio-demographic and medical/biological data as well as potential risk factors and mortality were recorded and analyzed. Twenty-three patients were included...
April 22, 2017: Anaerobe
https://www.readbyqxmd.com/read/28431896/pressurized-intraperitoneal-aerosol-chemotherapy-%C3%A2-practical-aspects
#20
M Hübner, F Grass, H Teixeira-Farinha, B Pache, P Mathevet, N Demartines
INTRODUCTION: Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) has been introduced as novel treatment for peritoneal carcinomatosis. Only proper patient selection, stringent safety protocol and careful surgery allow for a secure procedure. We hereby report the essentials for safe implementation. METHODS: All consecutive procedures within 20 months after PIPAC implementation were analyzed with regards to practical and surgical aspects. Special emphasis was laid on modifications of technique and safety measures during the implementation process with systematic use of a dedicated checklist...
April 8, 2017: European Journal of Surgical Oncology
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