keyword
MENU ▼
Read by QxMD icon Read
search

Peritoneal carcinomatosis

keyword
https://www.readbyqxmd.com/read/28222738/are-there-intra-operative-hemodynamic-differences-between-the-coliseum-and-closed-hipec-techniques-in-the-treatment-of-peritoneal-metastasis-a-retrospective-cohort-study
#1
Cristina Rodríguez Silva, Francisco Javier Moreno Ruiz, Inmaculada Bellido Estévez, Joaquin Carrasco Campos, Alberto Titos García, Manuel Ruiz López, Ivan González Poveda, Jose Antonio Toval Mata, Santiago Mera Velasco, Julio Santoyo Santoyo
BACKGROUND: Although two main methods of intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) are currently accepted, the superiority of one over the other has not yet been demonstrated. The purpose of this study was to determine whether there are hemodynamic and temperature differences between patients who received HIPEC in two different techniques, open versus closed abdomen. METHODS: This retrospective study was conducted in our center between 2011-2015 in 30 patients who underwent surgery for peritoneal carcinomatosis secondary to colorectal cancer, in whom cytoreduction and HIPEC were performed by the Coliseum (15) or closed techniques (15)...
February 21, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28210074/second-look-surgery-plus-hyperthermic-intraperitoneal-chemotherapy-for-patients-with-colorectal-cancer-at-high-risk-of-peritoneal-carcinomatosis-does-it-really-save-lives
#2
EDITORIAL
Delia Cortes-Guiral, Dominique Elias, Pedro Antonio Cascales-Campos, Alfredo Badía Yébenes, Ismael Guijo Castellano, Ana Isabel León Carbonero, José Ignacio Martín Valadés, Jesus Garcia-Foncillas, Damian Garcia-Olmo
The treatment of peritoneal carcinomatosis (PC) of colorectal origin with cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) has a 5-year recurrence-free or cure rate of at least 16%, so it is no longer labeled as a fatal disease, and offers prolonged survival for patients with a low peritoneal carcinomatosis index. Metachronous PC of colorectal origin is so predictable that there is a model which has been used to successfully determine the individual risk of each patient. Patients at risk are clearly identified; those with the highest risk have small peritoneal nodules present in the first surgery (70% probability of developing PC), ovarian metastases (60%), perforated tumor onset or intraoperative tumor rupture (50%)...
January 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28207504/unusual-presentation-of-direct-intraperitoneal-metastases-complicated-with-massive-ascites-from-plasmacytoid-variant-of-bladder-cancer-and-adenocarcinoma-of-colon-a-case-report-and-literature-review
#3
Yu-Hua Shao, Chien-Chang Kao, Shou-Hung Tang, Tai-Lung Cha, Chih-Wei Tsao, En Meng, Dah-Shyong Yu, Guang-Huan Sun, Sheng-Tang Wu
BACKGROUND: Plasmacytoid urothelial carcinoma (PUC) is a distinct variant of urinary bladder cancer, with a high propensity for invasion and poor prognosis. These tumors occur most commonly in male patients with the age of reported cases ranging from 46 to 87 years. CASE REPORT: We present a case of a 74-year-old male patient having massive ascites and bilateral lower leg edema. Colonoscopy showed a 3-cm lesion in the sigmoid colon and an edematous nonpapillary tumor was found by cystoscopy in the bladder...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28205261/stent-placement-prior-to-initiation-of-chemotherapy-in-patients-with-obstructive-nonoperative-left-sided-tumors-is-associated-with-fewer-stomas
#4
Javier Suárez, Gabriel Marín, Ruth Vera, Dorin Colibaseanu, Juan J Vila, Miguel A Ciga, Begoña Oronoz
BACKGROUND AND OBJETIVES: Due to the potential risks associated with stent placement, European Society Gastrointestinal Endoscopy does not recommend prophylactic insertion of stents in patients without symptoms. The aim was to compare complication rates, need of surgery, colostomy formation, and survival between stent placement prior to start of chemotherapy (SEMS group) and upfront ChT (ChT group) in patients with endoscopically non-transverable metastatic left-sided colorectal cancer...
February 15, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28191357/metastatic-invasive-lobular-breast-cancer-presenting-clinically-with-esophageal-dysphagia
#5
Lilit Karapetyan, Heather Laird-Fick, Reuben Cuison
Background. Intra-abdominal metastases of invasive lobular breast cancer (ILBC) may be insidious. We report a case of metastatic ILBC that presented with dysphagia within weeks of a negative mammogram and before the development of intra-abdominal symptoms. Case. A 70-year-old female developed esophageal dysphagia. She underwent EGD which showed a short segment of stricture of the distal esophagus without significant mucosal changes. Biopsy was unremarkable and patient underwent lower esophageal sphincter (LES) dilation...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/28190800/cocoon-carcinomatosa-an-unusual-cause-of-intestinal-obstruction
#6
Jimil Shah, Amit Kumar, Harjeet Singh, Roshan Agarwala, Vishal Sharma, Surinder S Rana
Abdominal cocoon, also termed sclerosing encapsulating peritonitis, is an uncommon entity associated with formation of a fibro-collagenous membrane around intestinal loops resulting in intestinal obstruction. Most reported cases are idiopathic, but many other causes have been implicated in cocoon formation, including use of continuous ambulatory peritoneal dialysis, peritoneal tuberculosis, and connective tissue disease. However, peritoneal carcinomatosis is a rarely reported entity that causes this condition...
February 13, 2017: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/28181817/mathematical-modeling-of-intraperitoneal-drug-delivery-simulation-of-drug-distribution-in-a-single-tumor-nodule
#7
Margo Steuperaert, Giuseppe Falvo D'Urso Labate, Charlotte Debbaut, Olivier De Wever, Christian Vanhove, Wim Ceelen, Patrick Segers
The intraperitoneal (IP) administration of chemotherapy is an alternative treatment for peritoneal carcinomatosis, allowing for higher intratumor concentrations of the cytotoxic agent compared to intravenous administration. Nevertheless, drug penetration depths are still limited to a few millimeters. It is thus necessary to better understand the limiting factors behind this poor penetration in order to improve IP chemotherapy delivery. By developing a three-dimensional computational fluid dynamics (CFD) model for drug penetration in a tumor nodule, we investigated the impact of a number of key parameters on the drug transport and penetration depth during IP chemotherapy...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28179354/accuracy-of-fdg-pet-ct-in-colorectal-peritoneal-carcinomatosis-potential-tool-for-evaluation-of-chemotherapeutic-response
#8
Gabriel Liberale, Céline Lecocq, Camilo Garcia, Kristof Muylle, Angélique Covas, Amélie Deleporte, Alain Hendlisz, Fikri Bouazza, Issam El Nakadi, Patrick Flamen
BACKGROUND/AIM: Neoadjuvant chemotherapy may be administered to patients with peritoneal carcinomatosis (PC) of colorectal cancer (CRC) origin. This study evaluated the performance of (18)fluorodeoxyglucose positron-emission tomography (FDG-PET)/computed tomography (CT) in detection of PC from CRC and correlated the most metabolically active quadrant with the most affected peritoneal area determined during surgery. PATIENTS AND METHODS: This retrospective study compared the performance of FDG-PET/CT for PC diagnosis in 26 patients with CRC with histopathologically-confirmed PC with a control group of 26 patients...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28179344/carbohydrate-antigen-19-9-predicts-synchronous-peritoneal-carcinomatosis-in-patients-with-colorectal-cancer
#9
Manabu Kaneko, Soichiro Ishihara, Koji Murono, Kazuhito Sasaki, Kensuke Otani, Koji Yasuda, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Kazushige Kawai, Hiroaki Nozawa, Hiroshi Nakayama, Toshiyuki Watanabe, Shin Sasaki, Toshiaki Watanabe
BACKGROUND: Colorectal cancer (CRC) with peritoneal carcinomatosis (PC) has the worst prognosis among all types of metastases, but is difficult to diagnose. This study investigated whether preoperative serum carbohydrate antigen (CA) 19-9 level can predict synchronous PC in patients with primary CRC. PATIENTS AND METHODS: The cases of 395 CRC patients who underwent primary lesion resection were retrospectively reviewed. Risk factors were evaluated by uni- and multivariate analyses from clinicopathological data...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28159747/nk-cell-recruitment-is-necessary-for-eradication-of-peritoneal-carcinomatosis-with-an-il12-expressing-maraba-virus-cellular-vaccine
#10
Almohanad A Alkayyal, Lee-Hwa Tai, Michael A Kennedy, Christiano Tanese de Souza, Jiqing Zhang, Charles Lefebvre, Shalini Sahi, Abhirami A Ananth, Ahmad Bakur Mahmoud, Andrew P Makrigiannis, Greg O Cron, Blair Macdonald, E Celia Marginean, David F Stojdl, John C Bell, Rebecca C Auer
Despite improvements in chemotherapy and radical surgical debulking, peritoneal carcinomatosis (PC) remains among the most common causes of death from abdominal cancers. Immunotherapies have been effective for selected solid malignancies, but their potential in PC has been little explored. Here, we report that intraperitoneal injection of an infected cell vaccine (ICV), consisting of autologous tumor cells infected ex vivo with an oncolytic Maraba MG1 virus expressing IL12, promotes the migration of activated natural killer (NK) cells to the peritoneal cavity in response to the secretion of IFNγ-induced protein-10 (IP-10) from dendritic cells...
February 3, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28143444/peritoneal-and-genital-coccidioidomycosis-in-an-otherwise-healthy-danish-female-a-case-report
#11
Ole Bæk, Karen Astvad, Reza Serizawa, Lawrence J Wheat, Pia T Brenøe, Ann-Brit E Hansen
BACKGROUND: Coccidioidomycosis is a fungal infection that usually presents as a primary lung infection. The fungus is endemic to the Southwest United States of America, northern Mexico and parts of Central and South America the infection is rare outside these areas. However, some patients develop disseminated infection that can lie dormant for several years and can present itself in travelers. We report the first case of extra pulmonary Coccidioidomycosis in a non-immunocompromised individual in Denmark...
January 31, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28138878/preoperative-platelet-lymphocyte-ratio-is-an-independent-prognostic-marker-and-superior-to-carcinoembryonic-antigen-in-colorectal-peritoneal-carcinomatosis-patients-undergoing-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#12
Tiffany Sin Hui Bong, Grace Hwei Ching Tan, Claramae Chia, Khee Chee Soo, Melissa Ching Ching Teo
OBJECTIVE: The aim of this study was to examine the prognostic significance of preoperative inflammatory-based indices, platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), and carcinoembryonic antigen (CEA) in predicting overall survival (OS) in patients with colorectal peritoneal carcinomatosis (CPC) treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). METHODS: Sixty patients with pathologically confirmed CPC treated with CRS and HIPEC between 2003 and 2015 were included...
January 30, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28133300/-a-case-of-undifferentiated-carcinoma-of-the-sigmoid-colon-that-responded-to-paclitaxel-and-carboplatin-chemotherapy
#13
Shingo Toyama, Katsuyoshi Kudoh, Shinobu Ohnuma, Satoko Sato, Naoki Tanaka, Takeshi Aoki, Hirofumi Imoto, Hideaki Karasawa, Kazuhiro Watanabe, Munenori Nagao, Tomoya Abe, Hiroaki Musha, Fuyuhiko Motoi, Takeshi Naitoh, Michiaki Unno
We report a case of a 72-year-old woman who was initially diagnosed with ovarian cancer with peritoneal carcinomatosis. Systemic chemotherapy consisting of paclitaxel and carboplatin(TC)was administered. Although a partial response(PR)was achieved after the 4 courses of TC, this regimen was discontinued due to severe adverse events. Ten months after discontinuation of TC, because abdominal CT and colonoscopy showed an intra-tumoral abscess caused by invasion of the tumor to the sigmoid colon, abdominal total hysterectomy, bilateral salpingo-oophorectomy, and a Hartmann's operation were performed to control the disease symptoms...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28124449/patients-experiences-of-their-everyday-life-14%C3%A2-months-after-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-a-qualitative-follow-up-study
#14
Christine Leo Swenne, Eva Jangland, Erebouni Arakelian
BACKGROUND: Patients with peritoneal carcinomatosis treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy have a long recovery process. AIM: To describe patients' experiences of their everyday lives after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. METHOD: A follow-up study with a qualitative, descriptive design. Data were collected by individual, in-depth telephone interviews with 16 patients who had been treated for peritoneal carcinomatosis 14 months earlier at a university hospital in Sweden...
January 25, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28114961/mif-cd74-axis-is-a-target-for-novel-therapies-in-colon-carcinomatosis
#15
Fabio Bozzi, Angela Mogavero, Luca Varinelli, Antonino Belfiore, Giacomo Manenti, Claudio Caccia, Chiara C Volpi, Galina V Beznoussenko, Massimo Milione, Valerio Leoni, Annunziata Gloghini, Alexandre A Mironov, Ermanno Leo, Silvana Pilotti, Marco A Pierotti, Italia Bongarzone, Manuela Gariboldi
BACKGROUND: Strategies aimed at obtaining a complete cytoreduction are needed to improve long-term survival for patients with colorectal cancer peritoneal carcinomatosis (CRC-pc). METHODS: We established organoid models from peritoneal metastases of two naïve CRC patients. A standard paraffin inclusion was conducted to compare their 3D structure and immunohistochemical profile with that of the corresponding surgical samples. RNA expression levels of the CRC stem cell marker LGR5 was measured by in situ hybridization...
January 23, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28109627/a-final-report-of-a-phase-i-study-of-veliparib-abt-888-in-combination-with-low-dose-fractionated-whole-abdominal-radiation-therapy-ldfwar-in-patients-with-advanced-solid-malignancies-and-peritoneal-carcinomatosis-with-a-dose-escalation-in-ovarian-and-fallopian
#16
Kim A Reiss, Joseph M Herman, Deborah Armstrong, Marianna Zahurak, Anthony Fyles, Anthony Brade, Michael Milosevic, Laura A Dawson, Angela Scardina, Patricia Fischer, Amy Hacker-Prietz, Robert J Kinders, Lihua Wang, Alice Chen, Sarah Temkin, Naomi Horiba, Lee-Anne Stayner, Lillian L Siu, Nilofer S Azad
BACKGROUND: The combination of low-dose radiation therapy with PARP inhibition enhances anti-tumor efficacy through potentiating DNA damage. We combined low-dose fractionated whole abdominal radiation (LDFWAR) with ABT-888 in patients with peritoneal carcinomatosis with a dose escalation in ovarian and fallopian cancer patients (OV). METHODS: Patients were treated with veliparib, 40-400mg orally BID on days 1-21 of 3 28-day cycles on 6 dose levels. Dose levels 5 and 6 included only OV patients...
January 18, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28099909/pathway-of-peritoneal-carcinomatosis-maybe-hematogenous-metastasis-rather-than-peritoneal-seeding
#17
Wei Ge, Gang Chen, Xiang-Shan Fan
GOALS: This study aimed to summarize the clinicopathological data of the cases of gastric cancer or colon cancer with regular metastasis in the mesentery of small intestine and explore the pathway of peritoneal carcinomatosis. MATERIALS AND METHODS: We retrospectively analyzed 5 cases of gastric cancer and 3 cases of colon cancer with regular metastasis in the mesentery of the small intestine from January 2014 to June 2016, including clinical information, gross manifestations during operation, treatment, and pathology...
January 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28099818/intraperitoneal-chemotherapy-and-cytoreductive-surgery-for-peritoneal-metastases-coupled-with-curative-treatment-of-colorectal-liver-metastases-an-updated-systematic-review
#18
Sarah El-Nakeep, Noha Rashad, Hani Oweira, Jan Schmidt, Daniel Helbling, Anwar Giryes, Ulf Petrausch, Arianeb Mehrabi, Michael Decker, Omar Abdel-Rahman
We aimed to assess the efficacy and safety of delivering intraperitoneal chemotherapy and cytoreductive surgery for peritoneal metastases coupled with curative treatment of colorectal liver metastases. Areas covered: A comprehensive literature search using PubMed was conducted to screen for eligible records. Studies evaluating colorectal surgery and intraperitoneal chemotherapy combined with curative treatment of liver metastases were included. We excluded duplicate publications. Sixty-seven full-text papers were assessed and six papers were finally included...
March 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28099801/highly-specific-and-sensitive-fluorescent-nanoprobes-for-image-guided-resection-of-sub-millimeter-peritoneal-tumors
#19
Aaron H Colby, Samantha M Berry, Ann M Moran, Kristine Amber Pasion, Rong Liu, Yolonda L Colson, Nelson Ruiz-Opazo, Mark W Grinstaff, Victoria L M Herrera
A current challenge in the treatment of peritoneal carcinomatosis is the inability to detect, visualize, and resect small or microscopic tumors of pancreatic, ovarian, or mesothelial origin. In these diseases, the completeness of primary tumor resection is directly correlated with patient survival, and hence, identifying small sub-millimeter tumors (i.e., disseminated disease) is critical. Thus, new imaging techniques and probes are needed to improve cytoreductive surgery and patient outcomes. Highly fluorescent rhodamine-labeled expansile nanoparticles (HFR-eNPs) are described for use as a visual aid during cytoreductive surgery of pancreatic carcinomatosis...
February 1, 2017: ACS Nano
https://www.readbyqxmd.com/read/28089175/reduction-of-carcinomatosis-risk-using-icodextrin-as-a-carrier-solution-of-intraperitoneal-oxaliplatin-chemotherapy
#20
I Jouvin, H Najah, C Pimpie, C Canet Jourdan, R Kaci, M Mirshahi, C Eveno, M Pocard
There is no standard treatment in patients with high risk metachronous peritoneal carcinomatosis (PC) in colonic cancer, as perforated tumour or synchronous ovarian metastasis. Icodextrin 4% (ICDX), presently used to prevent postoperative abdominal adhesions, could inhibit the coactivation of the tumour cells and the microenvironment cells, associated with the development of PC. The aim of this study was to inhibit the formation of the PC in a murine model mimicking surgical situation using ICDX and intraperitoneal (IP) prophylactic chemotherapy...
January 9, 2017: European Journal of Surgical Oncology
keyword
keyword
2559
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"