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Peritoneal carcinomatosis

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https://www.readbyqxmd.com/read/29033584/dna-ploidy-and-s-phase-fraction-analysis-in-peritoneal-carcinomatosis-from-ovarian-cancer-correlation-with-clinical-pathological-factors-and-response-to-chemotherapy
#1
Silvia Carloni, Giulia Gallerani, Anna Tesei, Emanuela Scarpi, Giorgio Maria Verdecchia, Salvatore Virzì, Francesco Fabbri, Chiara Arienti
OBJECTIVE: We investigated the correlation between ploidy or S-phase fraction (SPF) and the clinical pathological characteristics of patients with peritoneal carcinomatosis from ovarian cancer. We also assessed their relation with the in vivo and in vitro response to several chemotherapeutic agents. PATIENTS AND METHODS: Fifty-three patients with peritoneal carcinomatosis from ovarian cancer were enrolled. Frozen tumor tissue was dissociated by a detergent-trypsin method, and the resulting cell suspension was stained with RNase A and propidium iodide...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29032693/from-utopia-to-reality-increased-survival-in-peritoneal-carcinomatosis-treated-with-cytoreduction-and-hyperthermic-intraperitoneal-chemotherapy
#2
Juan José Segura-Sampedro, Rafael Morales-Soriano
We have read with great interest the article by Illán et al.1 entitled "Long survival in a patient with metastatic colorectal carcinoma: reality or utopia?" This article describes the case of a 42 year old patient with mucinous-type colon adenocarcinoma who had tumor recurrence with peritoneal metastases 18 months after resection of the primary tumor and adjuvant chemotherapy. After multiple metastasectomies and several lines of chemotherapy, the patient died 27 months after the recurrence.
October 16, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29024842/peritoneal-carcinomatosis-like-implants-of-extramedullary-hematopoiesis-an-insolite-occurrence-during-splenectomy-for-myelofibrosis
#3
Marco Casaccia, Rosario Fornaro, Marco Frascio, Denise Palombo, Cesare Stabilini, Emma Firpo, Ezio Gianetta
INTRODUCTION: Primary myelofibrosis (MF) is a myeloproliferative neoplasm that results in debilitating constitutional symptoms, splenomegaly, and cytopenias. In patients with symptomatic splenomegaly, splenectomy remains a viable treatment option for MF patients with medically refractory symptomatic splenomegaly that precludes the use of ruxolitinib. CASE PRESENTATION: We present the clinical case of a patient who was admitted to our Department to perform a splenectomy in MF as a therapeutic step prior to an allogeneic stem cell transplantation (ASCT)...
October 5, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29019283/antitumor-effectiveness-and-mechanism-of-action-of-ru-ii-amino-acid-diphosphine-complexes-in-the-peritoneal-carcinomatosis-progression
#4
Francyelli Mello-Andrade, Wanderson Lucas da Costa, Wanessa Carvalho Pires, Flávia de Castro Pereira, Clever Gomes Cardoso, Ruy de Souza Lino-Junior, Vicente Raul Chavarria Irusta, Cristiene Costa Carneiro, Paulo Roberto de Melo-Reis, Carlos Henrique Castro, Marcio Aurélio Pinheiro Almeida, Alzir Azevedo Batista, Elisângela de Paula Silveira-Lacerda
Peritoneal carcinomatosis is considered as a potentially lethal clinical condition, and the therapeutic options are limited. The antitumor effectiveness of the [Ru(l-Met)(bipy)(dppb)]PF6(1) and the [Ru(l-Trp)(bipy)(dppb)]PF6(2) complexes were evaluated in the peritoneal carcinomatosis model, Ehrlich ascites carcinoma-bearing Swiss mice. This is the first study that evaluated the effect of Ru(II)/amino acid complexes for antitumor activity in vivo. Complexes 1 and 2 (2 and 6 mg kg(-1)) showed tumor growth inhibition ranging from moderate to high...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28993033/ca-19-9-to-peritoneal-carcinomatosis-index-pci-ratio-is-prognostic-in-patients-with-epithelial-appendiceal-mucinous-neoplasms-and-peritoneal-dissemination-undergoing-cytoreduction-surgery-and-intraperitoneal-chemotherapy-a-retrospective-cohort-study
#5
Mathew A Kozman, Oliver M Fisher, Bree-Anne J Rebolledo, Sarah J Valle, Nayef Alzahrani, Winston Liauw, David L Morris
BACKGROUND: Serum tumour levels have been shown to be prognostic in patients with epithelial appendiceal mucinous neoplasms with peritoneal dissemination (pseudomyxoma peritonei (PMP)). A singular index which incorporates both tumour activity (as depicted by serum tumour marker levels) and tumour volume (as depicted by peritoneal carcinomatosis index (PCI)), may give a more precise surrogate of tumour biological behaviour. The prognostic implication of this index has not yet been reported...
September 19, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28985640/-prophylactic-appendectomy-yes-or-no
#6
Sabine Kersting, Periklis Dimasis, Siri Wiesmann, Ulrich Mittelkötter
Background At more than 50%, appendicitis is the leading cause of acute intra-abdominal disease requiring surgery. In the course of various other operations, prophylactic appendectomy (PA) is frequently performed. Objectives This study examines to what extent PA is justified. Patients and Methods A prospective study was performed in all patients (n = 173) undergoing prophylactic appendectomy in Katharinen Hospital Unna between January 2010 and October 2013. The following variables were analysed: age, gender, type of primary surgery, emergency or elective surgery, complications, lethality, intraoperative and histopathological evaluation of the appendix...
October 6, 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/28979717/stratification-of-outcomes-for-mucinous-appendiceal-adenocarcinoma-with-peritoneal-metastasis-by-histological-grade
#7
Travis Edward Grotz, Richard E Royal, Paul F Mansfield, Michael James Overman, Gary N Mann, Kristen Ashlee Robinson, Karen A Beaty, Safiea Rafeeq, Auerlio Matamoros, Michelle W Taggart, Keith Francis Fournier
AIM: To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma (MAA). METHODS: Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated...
September 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28965085/leiomyomatosis-peritonealis-disseminata-a-case-report-and-meticulous-review-of-the-literature
#8
Giannos Psathas, Maria Zarokosta, Menelaos Zoulamoglou, Dimosthenis Chrysikos, Ioannis Thivaios, Ioannis Kaklamanos, Konstantinos Birbas, Theodoros Mariolis-Sapsakos
INTRODUCTION: Leiomyomatosis peritonealis disseminata (LPD) is a peculiar benign clinical disorder characterized by proliferation of peritoneal and subperitoneal nodules. LPD is a difficultly diagnosed benign disease that rarely degenerates into malignancy. PRESENTATION OF CASE: A 40-year-old Caucasian female with vaginal bleeding proceeded to our institution for elective excision of abdominal and pelvic masses which were firstly considered as leiomyosarcomas. The histologic diagnosis of the mass lesions revealed smooth muscle benign cells...
September 23, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28964609/multicentric-initial-experience-with-the-use-of-the-pressurized-intraperitoneal-aerosol-chemotherapy-pipac-in-the-management-of-unresectable-peritoneal-carcinomatosis
#9
Mohammad Alyami, Johan Gagniere, Olivia Sgarbura, Delphine Cabelguenne, Laurent Villeneuve, Denis Pezet, Francois Quenet, Olivier Glehen, Naoual Bakrin, Guillaume Passot
BACKGROUND: PIPAC is a recent approach for intraperitoneal chemotherapy with promising results for patients with peritoneal carcinomatosis (PC). We aimed to evaluate the postoperative outcome of PIPAC in patients with non-resectable PC during our initial experience of the technique. METHODS: All patients who underwent PIPAC for non-resectable PC in three centers were analyzed regarding postoperative outcomes. RESULTS: Seventy-three patients underwent 164 PIPAC...
September 21, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28943914/metastatic-gastric-cancer-from-breast-carcinoma-a-report-of-78-cases
#10
Liang Xu, Shujing Liang, Ningning Yan, Le Zhang, Hailiang Gu, Xiaochun Fei, Yingchun Xu, Fengchun Zhang
The metastatic spread of breast carcinoma to the stomach is rare. There are a small number of previous studies that report metastases from the breast to the stomach and these provide limited information regarding this infrequent event. Consequently, the clinicopathological features, clinical outcomes and the optimal treatment for these patients remain to be elucidated. In the present study, 78 cases of gastric metastases from breast cancer, including the current case, were identified from previous studies between 1960 and 2015...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28929277/fluorescence-guided-surgery-in-the-combined-treatment-of-peritoneal-carcinomatosis-from-colorectal-cancer-preliminary-results-and-considerations
#11
Eva Lieto, Annamaria Auricchio, Francesca Cardella, Andrea Mabilia, Nicoletta Basile, Paolo Castellano, Michele Orditura, Gennaro Galizia
BACKGROUND: Indocyanine green (ICG) is a near-infrared fluorescent contrast agent, which preferentially accumulates in cancer tissue. The aim of our study was to investigate the role of fluorescence imaging (FI) with ICG (ICG-FI) for detecting peritoneal carcinomatosis (PC) from colorectal cancer (CRC). METHODS: Four CRC patients with PC scheduled for cytoreductive surgery + hyperthermic intraperitoneal chemotherapy were enrolled in this prospective study. At a median time of 50 min after 0...
September 19, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28910191/lysophosphatidic-acid-is-a-biomarker-for-peritoneal-carcinomatosis-of-gastric-cancer-and-correlates-with-poor-prognosis
#12
Ruolan Zeng, Bin Li, Junhui Huang, Meizuo Zhong, Li Li, Chaojun Duan, Shan Zeng, Jin Huang, Wei Liu, Jingchen Lu, Youhong Tang, Lingming Zhou, Yiping Liu, Jianhuang Li, Zhengxi He, Quan Wang, Youyi Dai
BACKGROUND: Peritoneal carcinomatosis (PC) is an important cause of morbidity and mortality among patients with gastric cancer. Thus, it is important to identify an ideal biomarker for PC. METHODS: Plasma and ascites samples were collected from gastric cancer patients with PC and a control group. Lysophosphatidic acid (LPA) levels were tested and analyzed. RESULTS: The plasma LPA levels of gastric cancer patients with PC were significantly higher than those in gastric cancer patients after radical resection (p = 0...
September 14, 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28903452/cytoreductive-surgery-plus-hyperthermic-intraperitoneal-chemotherapy-improves-survival-for-peritoneal-carcinomatosis-from-colorectal-cancer-a-systematic-review-and-meta-analysis-of-current-evidence
#13
REVIEW
Chao-Qun Huang, Yao Min, Shu-Yi Wang, Xiao-Jun Yang, Yang Liu, Bin Xiong, Yutaka Yonemura, Yan Li
OBJECTIVES: The therapeutic efficacy of cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with peritoneal carcinomatosis (PC) from colorectal cancer (CRC) is still under debate. This meta-analysis and systematic review of published literature on this comprehensive strategy aims to evaluate its efficacy on CRC patients with PC. METHODS: A systemic review with meta-analysis of published literatures on treatment of CRS plus HIPEC for patients with PC from CRC was performed...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28900843/pressurized-intraperitoneal-aerosol-chemotherapy-pipac-procedure-for-non-resectable-peritoneal-carcinomatosis-with-video
#14
Jean-Baptiste Cazauran, Mohammad Alyami, Antoinette Lasseur, Isabo Gybels, Olivier Glehen, Naoual Bakrin
BACKGROUND: Peritoneal carcinomatosis (PC) is a common evolution of abdominal cancers and is associated with poor prognosis in the absence of aggressive multimodal therapy.1 Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a safe and innovative approach, which enhances the effect of chemotherapy 2 without reported renal/hepatic toxicity.3,4 It requires mastery of technical aspects to reduce postoperative morbidity, increase effectiveness, and prevent caregiver chemotherapy exposure...
September 12, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28895112/external-validation-of-the-prognostic-nomogram-compass-for-patients-with-peritoneal-carcinomatosis-of-colorectal-cancer
#15
Karel Demey, Albert Wolthuis, Anthony de Buck van Overstraeten, Steffen Fieuws, Vincent Vandecaveye, Eric Van Cutsem, André D'Hoore
BACKGROUND: To optimize outcome, selection of patients for cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is critical. Recently, Simkens et al.7 evaluated the peritoneal surface disease severity score (PSDSS) and suggested a new prognostic nomogram, the colorectal peritoneal metastases prognostic surgical score (COMPASS) based on age, peritoneal carcinomatosis index score, locoregional lymph node status, and signet ring cell histology. This COMPASS nomogram had better discriminative ability according to the Harrell c-index than PSDSS (c = 0...
September 11, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28890671/current-management-of-peritoneal-carcinomatosis-from-colorectal-cancer-the-role-of-cytoreductive-surgery-and-hyperthermic-peritoneal-chemoperfusion
#16
Ibrahim Nassour, Patricio M Polanco
Peritoneal carcinomatosis (PC) from colorectal cancer (CRC) is a disease with a poor prognosis, often thought to be a terminal illness with no hope except for palliative treatment. New therapeutic modalities combining cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have shown favorable outcomes and may provide a significant survival benefit in a selected group of patients. The main rational for CRS is to remove all visible tumor burden to allow for the chemotherapeutic agent (HIPEC) to eradicate any microscopic residual disease...
April 2017: Current Colorectal Cancer Reports
https://www.readbyqxmd.com/read/28888800/percutaneous-lung-ablation-of-pulmonary-recurrence-may-improve-survival-in-selected-patients-undergoing-cytoreductive-surgery-for-colorectal-cancer-with-peritoneal-carcinomatosis
#17
T A Bin Traiki, O M Fisher, S J Valle, R N Parikh, M A Kozman, D Glenn, M Power, W Liauw, N A Alzahrani, D L Morris
PURPOSE: To analyze the outcomes of patients developing pulmonary metastases (PM) following cytoreductive surgery (CRS) and perioperative intra-peritoneal chemotherapy (IPC) for colorectal cancer (CRC) with peritoneal carcinomatosis. PATIENTS AND METHODS: A retrospective analysis of patients undergoing CRS/IPC for CRC from 1996 to 2016 was performed. Lung-specific disease-free and patient overall survival was analyzed. Patients undergoing percutaneous lung ablative therapy (PLAT) for PM were compared to patients receiving systemic chemotherapy alone...
October 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28888540/feasibility-safety-and-clinical-outcomes-of-cardiophrenic-lymph-node-resection-in-advanced-ovarian-cancer
#18
Renee A Cowan, Jill Tseng, Vijayashree Murthy, Radhika Srivastava, Kara C Long Roche, Oliver Zivanovic, Ginger J Gardner, Dennis S Chi, Bernard J Park, Yukio Sonoda
OBJECTIVES: Surgical resection of enlarged cardiophrenic lymph nodes (CPLNs) in primary treatment of advanced ovarian cancer has not been widely studied. We report on a cohort of patients undergoing CPLN resection during primary cytoreductive surgery (CRS), examining its feasibility, safety, and potential impact on clinical outcomes. METHODS: We identified all patients undergoing primary CRS/CPLN resection for Stages IIIB-IV high-grade epithelial ovarian cancer at our institution from 1/2001-12/2013...
September 6, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28874817/armored-car-t-cells-enhance-antitumor-efficacy-and-overcome-the-tumor-microenvironment
#19
Oladapo O Yeku, Terence J Purdon, Mythili Koneru, David Spriggs, Renier J Brentjens
Chimeric antigen receptor (CAR) T cell therapy has shown limited efficacy for the management of solid tumor malignancies. In ovarian cancer, this is in part due to an immunosuppressive cytokine and cellular tumor microenvironment which suppresses adoptively transferred T cells. We engineered an armored CAR T cell capable of constitutive secretion of IL-12, and delineate the mechanisms via which these CAR T cells overcome a hostile tumor microenvironment. In this report, we demonstrate enhanced proliferation, decreased apoptosis and increased cytotoxicity in the presence of immunosuppressive ascites...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28868010/clinical-benefit-from-trametinib-in-a-patient-with-appendiceal-adenocarcinoma-with-a-gnas-r201h-mutation
#20
Celina Ang, Aryeh Stollman, Hongfa Zhu, Umut Sarpel, Bethann Scarborough, Gagan Sahni, Sherri Z Millis
We report the case of a patient with appendiceal adenocarcinoma with mucinous peritoneal carcinomatosis who was treated with trametinib upon identification of a GNAS R201H mutation by comprehensive genomic profiling. The molecular pathology of appendiceal neoplasms is reviewed, and the mechanistic basis underlying the clinical benefit as well as the subsequent course on trametinib that were observed in this patient are discussed.
May 2017: Case Reports in Oncology
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