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Peritoneal carcinomatosis

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https://www.readbyqxmd.com/read/28730797/ileal-perforation-following-cetuximab-and-folfiri-chemotherapy-in-a-patient-with-ascending-colon-cancer-with-peritoneal-carcinomatosis
#1
Young Wan Kim
No abstract text is available yet for this article.
May 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28730790/perioperative-systemic-chemotherapy-for-peritoneal-mucinous-appendiceal-carcinomas-treated-with-cytoreductive-surgery-hipec
#2
John Spiliotis, Nikolaos Kopanakis, Elias Efstathiou, Dimitra Vassiliadou, Orestis Argiriou, Athanassios Rogdakis, Christos Valavanis
PURPOSE: To identify the role of systemic chemotherapy in the management of appendiceal malignancies. METHODS: Over a 10-year period (2005 -2014), 52 patients with appendiceal neoplasms were treated at our Peritoneal Surface Malignancy Unit [14 (26.9%) disseminated peritoneal adenomucinosis (DPAM), 30 (57.7%) peritoneal mucinous carcinomatosis of appendiceal origin (PMCA) and 8 (15.4%) PMCA-I]. All patients (100%) underwent cytoreductive surgery (CRS) & hyperthermic intraperitoneal chemotherapy (HIPEC), while 20 (38...
May 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28726044/computed-tomographic-characteristics-for-patients-with-unresectable-gastric-cancer-harboring-low-volume-peritoneal-carcinomatosis
#3
Jhe-Cyuan Guo, Chin-Chen Chang, Chung-Yi Yang, Bin-Chi Liao, Jau-Yu Liau, Chin-Hao Chang, Kun-Huei Yeh
Although current staging workups could differentiate most patients with operable from inoperable advanced gastric cancers, there are still some patients with low-volume peritoneal carcinomatosis, defined as only metastasis with multiple subcentimeter lesions in peritoneum, receiving unnecessary open-close procedures. The computed tomography (CT) of the patients with unresectable advanced gastric cancer harboring low-volume peritoneal carcinomatosis was retrospectively identified and then thoroughly reviewed by two independent radiologists unaware of the peritoneal carcinomatosis status...
August 2017: Medical Oncology
https://www.readbyqxmd.com/read/28722107/the-peritoneum-healing-immunity-and-diseases
#4
REVIEW
Annalisa Capobianco, Lucia Cottone, Antonella Monno, Angelo A Manfredi, Patrizia Rovere-Querini
The peritoneum defines a confined microenvironment, which is stable under normal conditions, but is exposed to the damaging effect of infections, surgical injuries, and other neoplastic and non-neoplastic events. Its response to damage includes the recruitment, proliferation and activation of a variety of haematopoietic and stromal cells. In physiologic conditions, effective responses to injuries are organized, inflammatory triggers are eliminated, inflammation quickly abates, and the normal tissue architecture is restored...
July 19, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28720378/a-novel-technique-carbon-dioxide-gas-assisted-total-peritonectomy-diaphragm-and-intestinal-meso-stripping-in-open-surgery-for-advanced-ovarian-cancer-%C3%A3-ukurova-technique
#5
Ghanim Khatib, Ahmet Baris Guzel, Umran Kucukgoz Gulec, Mehmet Ali Vardar
OBJECTIVE: Most of the ovarian cancers are diagnosed at advanced stages. As peritoneal carcinomatosis increases, especially when it extends to the diaphragm and intestinal mesos, probability of obtaining complete cytoreduction is reduced. Complete cytoreduction (residue zero: R0) is one of the main factors affecting survival [1-3]. Here we present a novel technique of stripping the peritoneal surfaces as a part of cytoreductive surgery in such cases. METHODS: A 55year-old woman diagnosed with peritoneal carcinomatosis was considered appropriate for primary cytoreduction after assessment of her thorax-abdominopelvic tomography, which revealed resectable intra-abdominal disease...
July 15, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28719887/anesthetic-management-of-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-crs-hipec-the-importance-of-hydro-electrolytic-and-acid-basic-control
#6
Fabrício Tavares Mendonça, Marília Moreira Guimarães, Sérgio Honorato de Matos, Rúbia Garcia Dusi
JUSTIFICATION AND OBJECTIVES: Patients affected by gynecological or gastrointestinal tract neoplasms that evolve to peritoneal carcinomatosis experience a significant drop in their quality of life, high morbidity and short survival times with currently available chemotherapeutic schemes. The surgical treatment based on cytoreduction and the employment of hyperthermic intraperitoneal chemotherapy in the intra-operative period is a true challenge to anesthesiologist. CASE REPORT: A 67 years old patient diagnosed with mucinous adenocarcinoma of the Appendix associated with mucinous carcinomatosis, was submitted to cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), under general anesthesia and epidural block...
July 10, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28718815/regional-delivery-of-chimeric-antigen-receptor-car-t-cells-for-cancer-therapy
#7
REVIEW
Praveen Sridhar, Fabio Petrocca
Chimeric Antigen Receptor (CAR) T-cells are T-cells with recombinant receptors targeted to tumor antigens. CAR-T cell therapy has emerged as a mode of immunotherapy and is now being extensively explored in hematologic cancer. In contrast, CAR-T cell use in solid tumors has been hampered by multiple obstacles. Several approaches have been taken to circumvent these obstacles, including the regional delivery of CAR-T cells. Regional CAR-T cell delivery can theoretically compensate for poor T-cell trafficking and tumor antigen specificity while avoiding systemic toxicity associated with intravenous delivery...
July 18, 2017: Cancers
https://www.readbyqxmd.com/read/28715968/applications-of-hyperthermic-intraperitoneal-chemotherapy-for-metastatic-colorectal-cancer
#8
Matthias Hornung, Jens M Werner, Hans J Schlitt
Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) plays a pivotal role in the current treatment of peritoneal carcinomatosis (PC) from colorectal cancer (CRC). Since the first demonstration, benefits for patients and especially an increase in survival have been described. In recent years, feasibility, efficacy and safety of HIPEC have been improved and progress has been made in understanding its oncological mechanism. Areas Covered: In this article, leading publications have been reviewed including clinical trials to describe the clinical presentation of PC due to CRC and present recent evidence of the CRS/HIPEC procedure...
July 18, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28709979/reconstruction-after-ureteral-resection-during-hipec-surgery-re-implantation-with-uretero-neocystostomy-seems-safer-than-end-to-end-anastomosis
#9
U Pinar, J-F Tremblay, G Passot, M Dazza, O Glehen, J-J Tuech, M Pocard
INTRODUCTION: Resection of the pelvic ureter may be necessary in cytoreductive surgery for peritoneal carcinomatosis in combination with hyperthermic intraperitoneal chemotherapy (HIPEC). As the morbidity for cytoreductive surgery with HIPEC has decreased, expert teams have begun to perform increasingly complex surgical procedures associated with HIPEC, including pelvic reconstructions. After ureteral resection, two types of reconstruction are possible: uretero-ureteral end-to-end anastomosis and uretero-vesical re-implantation or uretero-neocystostomy (the so-called psoas hitch technique)...
July 11, 2017: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/28705789/treatment-of-peritoneal-dissemination-in-stomach-cancer-patients-with-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-hipec-rationale-and-design-of-the-periscope-study
#10
Rosa T van der Kaaij, Hidde Jw Braam, Henk Boot, Maartje Los, Annemieke Cats, Cecile Grootscholten, Jan Hm Schellens, Arend Gj Aalbers, Alwin Dr Huitema, Catherijne Aj Knibbe, Djamila Boerma, Marinus J Wiezer, Bert van Ramshorst, Johanna W van Sandick
BACKGROUND: Patients with gastric cancer and peritoneal carcinomatosis have a very poor prognosis; median survival is 3 to 4 months. Palliative systemic chemotherapy is currently the only treatment available in the Netherlands. Intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) has an established role in the treatment of peritoneal carcinomatosis originating from colorectal cancer, appendiceal cancer, and pseudomyxoma peritonei; its role in gastric cancer is uncertain. Currently, there is no consensus on the choice of chemotherapeutic agents used in HIPEC for gastric cancer...
July 13, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28704322/malignant-bowel-obstruction-in-relapsed-ovarian-cancer-with-peritoneal-carcinomatosis-an-occlusive-state
#11
Pedro Martinez Castro, Lara Vargas, Antonio Mancheño, Salvador Martín Utrilla, Francisco Pascual, Ignacio Romero, Cristina Zorrero, José Manuel Bosch, Andrés Poveda, Lucas Minig
OBJECTIVE: The aim of this study was to describe the clinical and oncological outcomes of women with malignant bowel obstruction (MBO) for relapsed ovarian cancer and peritoneal carcinomatosis. METHODS: A retrospective cohort study was performed in all consecutive patients admitted at Instituto Valenciano de Oncología, Valencia, Spain, between July 2013 and July 2016 with MBO for relapsed ovarian cancer and peritoneal carcinomatosis. All patients underwent the same protocol of conservative management...
July 12, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28697322/many-challenges-of-peritoneal-carcinomatosis
#12
Aaron R Sasson, Joseph Kim
No abstract text is available yet for this article.
July 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28697317/management-of-malignant-bowel-obstruction-associated-with-gi-cancers
#13
Aaron J Franke, Atif Iqbal, Jason S Starr, Rajesh M Nair, Thomas J George
For many patients with GI malignancies, the seeding of the abdominal cavity with tumor cells, called peritoneal carcinomatosis, is a common mode of metastases and disease progression. Prognosis for patients with this aspect of their disease remains poor, with high disease-related morbidity and complications. Uniform and proven practices that provide optimal palliative care and quality of life for these patients are needed. The objective of this review is to critically assess the current literature regarding palliative strategies in the management of peritoneal carcinomatosis and associated symptoms in patients with advanced GI cancers...
July 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28695394/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-moderately-and-poorly-differentiated-appendiceal-adenocarcinoma-survival-outcomes-and-patient-selection
#14
Travis E Grotz, Michael J Overman, Cathy Eng, Kanwal P Raghav, Richard E Royal, Paul F Mansfield, Gary N Mann, Kristen A Robinson, Karen A Beaty, Safia Rafeeq, Aurelio Matamoros, Melissa W Taggart, Keith F Fournier
BACKGROUND: Moderately and poorly differentiated adenocarcinoma of the appendix represents an aggressive histological variant with a high risk of recurrence and death. METHODS: Overall, 178 patients with moderately and poorly differentiated appendiceal adenocarcinoma were identified from a prospective database. Clinical, pathologic, and treatment factors were analyzed for outcomes. RESULTS: Diagnostic laparoscopy (DL) identified radiographic occult peritoneal metastasis in 25 (42%) patients...
July 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28689443/does-having-a-gastrectomy-delay-time-to-feeding-and-prolong-hospital-stay-in-patients-undergoing-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#15
Nicholas B Shannon, Grace Hwei Ching Tan, Claramae Shulyn Chia, Khee Chee Soo, Melissa Ching Teo
AIM: Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) are routinely used to treat selected patients with peritoneal carcinomatosis, but can be associated with prolonged hospital stay, significant morbidity and mortality. Our objective was to assess whether patients undergoing gastrectomy as part of CRS/HIPEC were at increased risk of delayed feeding time and prolonged hospital stay. METHOD: 214 consecutive patients with peritoneal carcinomatosis treated with CRS/HIPEC between 2001 and 2016 were stratified by whether CRS included gastrectomy (n = 19, 9%) and compared...
July 9, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28679331/predictive-value-of-peritoneal-cancer-index-for-survival-in-patients-with-mucinous-peritoneal-malignancies-treated-with-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-a-single-center-experience
#16
Andreas Brandl, Sascha Weiss, Moritz von Winterfeld, Alexander Krannich, Matthilde Feist, Johann Pratschke, Wieland Raue, Beate Rau
OBJECTIVES: This study investigated the correlation between the peritoneal carcinomatosis index (PCI) and patient outcome depending on the tumor type. BACKGROUND: Peritoneal surface malignancy (PSM) treatment depends on tumor type. Mucinous PSM (m-PSM) is associated with a better prognosis than non-mucinous PSM (nm-PSM). The PCI´s predictive ability has not yet been evaluated. METHODS: We analyzed 123 patients with PSM treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) between 2008 and 2015...
July 5, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28668403/f-18-fdg-pet-ct-metabolic-tumor-volume-predicts-overall-survival-in-patients-with-disseminated-epithelial-ovarian-cancer
#17
Rosj Gallicchio, Anna Nardelli, Angela Venetucci, Daniela Capacchione, Alessandra Pelagalli, Cesare Sirignano, Pierpaolo Mainenti, Piernicola Pedicini, Giuseppe Guglielmi, Giovanni Storto
OBJECTIVE: We evaluated the prognostic impact of quantitative assessment by maximum standardized uptake value (SUVmax), metabolic tumour volume (MTV) and tumour lesion glycolysis (TLG) on [F-18] FDG PET/CT for patients with peritoneal carcinomatosis from epithelial ovarian cancer (EOC). METHODS: Thirty-one patients with EOC underwent PET/CT for an early restaging after cytoreductive surgery, having been diagnosed with carcinomatosis (before chemotherapy). The SUVmax, MTV (cm(3); 42% threshold) and TLG (g) were registered on residual peritoneal lesions...
August 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28664645/treatment-of-peritoneal-carcinomatosis-with-hyperthermic-intraperitoneal-chemotherapy-in-colorectal-cancer
#18
REVIEW
Corina Behrenbruch, Frédéric Hollande, Benjamin Thomson, Michael Michael, Satish K Warrier, Craig Lynch, Alexander Heriot
The peritoneum is the second most common site of metastasis after the liver and the only site of metastatic disease in approximately 25% of patients with colorectal cancer (CRC). In the past, peritoneal carcinomatosis in CRC was thought to be equivalent to distant metastasis; however, the transcoelomic spread of malignant cells is an acknowledged alternative pathway. Metastasectomy with curative intent is well accepted in patients with liver metastasis in CRC despite the paucity of randomized trials. Therefore, there is rationale for local treatment with peritonectomy to eliminate macroscopic disease, followed by hyperthermic intraperitoneal chemotherapy to destroy any residual free tumour cells within the peritoneal cavity...
June 30, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28659008/pain-mechanisms-in-peritoneal-diseases-might-be-partially-regulated-by-estrogen
#19
Clara Börner, Claudia Scheerer, Rene Buschow, Vito Chiantera, Jalid Sehouli, Sylvia Mechsner
To identify factors influencing the differential pain pathogenesis in peritoneal endometriosis (pEM) and peritoneal carcinomatosis in ovarian cancer (pOC), we undertook an experimental study. Tissue samples of 18 patients with pEM, 15 patients with pOC, and 15 unaffected peritoneums as controls were collected during laparoscopy or laparotomy. Immunohistochemical stainings were conducted to identify nerve fibers and neurotrophins in the tissue samples. Additionally, 23 pEM fluids, 25 pOC ascites fluids, and 20 peritoneal fluids of patients with myoma uteri as controls were collected...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28651922/peritoneal-carcinomatosis-in-primary-ovarian-cancer-ultrasound-detection-and-comparison-with-computed-tomography
#20
Zhenhong Qi, Yixiu Zhang, Qing Dai, Yu Xia, Yuxin Jiang
We retrospectively compared detection rates and consistency for diagnosis of peritoneal carcinomatosis (PC) of primary ovarian cancer (OC) between ultrasound (US) and computed tomography (CT) scans in 41 patients whose PC of OC (stages IIC-IV) had been diagnosed by histopathology findings. Compared with CT detection rates, those for US were significantly higher for metastases to the pelvic area (92.3% vs. 43.6%, p < 0.001) and bowel surface (64.0% vs. 16.0%, p = 0.002); however, they did not significantly differ for other sites: omentum, diaphragm, lateral peritoneum, mesenteric, hepatic and splenic surfaces...
June 23, 2017: Ultrasound in Medicine & Biology
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