keyword
https://read.qxmd.com/read/38096632/testing-for-clomiphene-in-keratinous-matrices-using-lc-ms-ms-in-doping-purpose-is-a-single-intake-of-clomiphene-detectable-in-hair-and-nail-clippings
#1
JOURNAL ARTICLE
Laurie Gheddar, Alice Ameline, Nadia Arbouche, Adeline Blanchot, Jean-Sébastien Raul, Pascal Kintz
Clomiphene is a selective estrogen receptor modulator. It is indicated for the treatment of female infertility issues but in sport, it can be misused to stimulate endogenous testosterone secretion in men. Therefore, it has been prohibited at all times by the World Anti-doping Agency. The aim of this study was to get data to be able to interpret concentrations in athletes. A healthy volunteer (male, 62 years-old) ingested a single therapeutic dose of clomiphene (Clomid™, 50 mg). Strands of hair (blond, 4 cm) were collected one month after the ingestion...
November 29, 2023: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/38082334/de-novo-variants-identified-by-trio-whole-exome-sequencing-of-bladder-exstrophy-epispadias-complex
#2
JOURNAL ARTICLE
Angie C Jelin, Elizabeth Wohler, Renan Martin, Heather Di Carlo, William Isaacs, Joan Ko, Jason Michaud, Karin Blakemore, David Valle, Nara Sobreira, John Gearhart
Bladder exstrophy epispadias complex (BEEC) encompasses a spectrum of conditions ranging from mild epispadias to the most severe form: omphalocele-bladder exstrophy-imperforate anus-spinal defects (OEIS). BEEC involves abnormalities related to anatomical structures that are proposed to have a similar underlying etiology and pathogenesis. In general, BEEC, is considered to arise from a sequence of events in embryonic development and is believed to be a multi-etiological disease with contributions from genetic and environmental factors...
December 11, 2023: American Journal of Medical Genetics. Part A
https://read.qxmd.com/read/38022255/anti-m%C3%A3-llerian-hormone-a-predictor-of-successful-intrauterine-insemination
#3
JOURNAL ARTICLE
Allison Stalzer, Dara Seybold, Pickens Gantt, Mike Broce, Ashley Cronkright
INTRODUCTION: The anti-Müllerian hormone (AMH) produced by the granulosa cells of ovarian follicles has been shown to correlate with ovarian reserve and is often measured for fertility therapies. In this study, we evaluated the relationship between serum AMH values and the clinical pregnancy (CP) rates of female partners with unexplained infertility undergoing intrauterine insemination utilizing varying ovarian simulation protocols. METHODS: This is a retrospective cohort study conducted among couples who underwent intrauterine insemination therapy over a period of four years at Charleston Area Medical Center, a tertiary care medical center in West Virginia, USA...
October 2023: Curēus
https://read.qxmd.com/read/37769866/fertility-outcomes-in-men-with-prior-history-of-anabolic-steroid-use
#4
JOURNAL ARTICLE
Braian R Ledesma, Alexander Weber, Greeshma Venigalla, Akhil Muthigi, Jamie Thomas, Manish Narasimman, Joshua White, Ranjith Ramasamy
OBJECTIVE: To study sperm parameters recovery and fertility outcomes in men with azoospermia or severe oligospermia caused by anabolic steroid use who underwent a standardized treatment regimen for spermatogenesis recovery. DESIGN AND SUBJECTS: A retrospective analysis of a cohort of men with a prior history of anabolic steroid use and infertility complaints (between 2018 and 2022) was conducted. EXPOSURE: The standardized treatment approach involved discontinuing testosterone replacement therapy and administering a combination regimen of clomiphene citrate and human chorionic gonadotropin for a minimum of 3 to 6 months...
December 2023: Fertility and Sterility
https://read.qxmd.com/read/37520487/comparing-efficacy-and-safety-of-stair-step-protocols-for-clomiphene-citrate-and-letrozole-in-ovulation-induction-for-women-with-polycystic-ovary-syndrome-pcos-a-randomized-controlled-clinical-trial
#5
RANDOMIZED CONTROLLED TRIAL
Saba Al-Thuwaynee, Asmaa Abdul Jaleel Swadi
Polycystic ovary syndrome (PCOS) is characterized by menstrual irregularities, high androgen levels, and ovarian cysts. Clomiphene citrate (Clomid) and letrozole have both been investigated as ovulation induction therapies for PCOS. This interventional study aimed to compare the efficacy and safety of a stairstep practice of letrozole versus clomiphene citrate in women with PCOS. A total of 100 women diagnosed with PCOS and infertility participated in the study, which took place from March 2021 to July 2022 at the Maternity and Children Teaching Hospital in Adiwaniyah Province, Iraq...
May 2023: Journal of Medicine and Life
https://read.qxmd.com/read/37290111/intrauterine-insemination-after-human-chorionic-gonadotropin-trigger-or-luteinizing-hormone-surge-a-meta-analysis
#6
JOURNAL ARTICLE
Nivedita R Potapragada, Elnur Babayev, Danielle Strom, Molly Beestrum, Jacob M Schauer, Emily S Jungheim
OBJECTIVE: To assess the odds of pregnancy after intrauterine insemination (IUI) timed by ultrasound monitoring and human chorionic gonadotropin (hCG) administration compared with monitoring luteinizing hormone (LH) levels. DATA SOURCES: We searched PubMed (MEDLINE), EMBASE (Elsevier), Scopus (Elsevier), Web of Science (Clarivate Analytics), ClinicalTrials.gov (National Institutes of Health), and the Cochrane Library (Wiley) from the inception until October 1, 2022...
June 8, 2023: Obstetrics and Gynecology
https://read.qxmd.com/read/35697286/vnotes-for-ovarian-drilling-a-new-minimal-invasive-technique
#7
JOURNAL ARTICLE
Margaux Jegaden, Elodie Debras, Anne-Gaëlle Pourcelot, Perrine Capmas, Hervé Fernandez
STUDY OBJECTIVE: To show a new mini-invasive surgical technique of ovarian drilling and fertility workup using transvaginal natural orifice transluminal endoscopic surgery (vNOTES). DESIGN: Stepwise demonstration of the technique with narrated video footage. SETTING: Ovarian drilling is a surgical technique for patients with dysovulatory polycystic ovary syndrome. The aim of this technique is to destroy 5% to 10% of the ovarian cortex to restore spontaneous ovulation...
August 2022: Journal of Minimally Invasive Gynecology
https://read.qxmd.com/read/33451262/multiple-pregnancy-rate-in-patients-undergoing-treatment-with-clomifene-citrate-for-who-group-ii-ovulatory-disorders-a-systematic-review
#8
REVIEW
Heather Garthwaite, Jane Stewart, Scott Wilkes
Clomifene citrate has long been associated with a multiple pregnancy rate of up to 8-10%. Studies from which these figures originated have largely included patients who received clomifene outside of current national and international treatment guidelines. In January 2020, a systematic review of MEDLINE and relevant reference lists was conducted. Studies were included that reported multiple pregnancy rate in a cohort of patients undergoing treatment with single agent clomifene citrate for WHO group II dysovulatory subfertility...
October 2022: Human Fertility: Journal of the British Fertility Society
https://read.qxmd.com/read/32803421/intrauterine-insemination-cycles-prediction-of-success-and-thresholds-for-poor-prognosis-and-futile-care
#9
JOURNAL ARTICLE
Alessandra J Ainsworth, Emily P Barnard, Sarah C Baumgarten, Amy L Weaver, Zaraq Khan
PURPOSE: We aimed to define intrauterine insemination (IUI) cycle characteristics associated with viable birth, identify thresholds below which IUI treatments are consistent with very poor prognosis and futile care, and develop a nomogram for individualized application. METHODS: This retrospective cohort study evaluated couples using fresh partner ejaculate for IUI from January 2005 to September 2017. Variables included female age, semen characteristics, and ovarian stimulation type...
August 15, 2020: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/32363556/the-efficacy-of-vitamin-d-combined-with-clomiphene-citrate-in-ovulation-induction-in-overweight-women-with-polycystic-ovary-syndrome-a-double-blind-randomized-clinical-trial
#10
RANDOMIZED CONTROLLED TRIAL
Radwa Rasheedy, Hazem Sammour, Abdellatif Elkholy, Yasmine Salim
PURPOSE: The aim of this study was to assess the effect of vitamin D supplementation on ovulation rate in overweight subfertile women with PCOS undergoing ovulation induction. METHODS: This was a single center, parallel-groups, double-blind, and placebo-controlled randomized trial involving 186 eligible women undergoing induction of ovulation with clomiphene citrate (Clomid®, Aventis) 50 mg tablet twice daily starting from the third day of menstrual cycle and for 5 days combined with either oral Vitamin D (ossofortin®, EVA PHARMA) 10,000 IU twice weekly and calcium (calciprex®, Marcyrl Pharmaceutical Industries) 1250 mg twice daily or to receive a placebo with calcium for three successive induction cycles...
August 2020: Endocrine
https://read.qxmd.com/read/31173495/clomiphene-citrate-ameliorated-lead-acetate-induced-reproductive-toxicity-in-male-wistar-rats
#11
JOURNAL ARTICLE
Oyeyemi A Wahab, Anyanwu C Princely, Akinola A Oluwadamilare, Daramola O Ore-Oluwapo, Alli O Blessing, Ehiaghe F Alfred
OBJECTIVE: The current study investigated the effects of clomiphene citrate on the hypothalamic-pituitary-testicular axis, steroidogenesis, sperm parameters, and testicular antioxidant enzyme activity of male Wistar rats submitted to lead acetate (Pb)-induced reproductive toxicity. METHODS: Twenty adult male Wistar rats were divided into four groups of equal size as follows: Control; Clomid (0.35 mg/kg); Pb (10 mg/kg); and Clomid + Pb. Serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone, testicular 17-β hydroxysteroid dehydrogenase (17-β HSD) activity, androgen receptors, catalase activity, superoxide dismutase (SOD), malondialdehyde (MDA), sperm motility, viability, counts and morphology were estimated after oral administration of Clomid and/or lead acetate for 35 consecutive days...
June 7, 2019: JBRA Assisted Reproduction
https://read.qxmd.com/read/31112853/the-impact-of-cross-border-ivf-on-maternal-and-neonatal-outcomes-in-multiple-pregnancies-experience-from-a-uk-fetal-medicine-service
#12
JOURNAL ARTICLE
Raj Jaspal, Thomas Prior, Jane Denton, Rehan Salim, Jayanta Banerjee, Christoph Lees
OBJECTIVES: To determine whether women seeking NHS care for IVF multiple pregnancies were more likely to have sought IVF treatment overseas and whether this was associated with different maternal and neonatal outcomes. STUDY DESIGN: A single large tertiary centre, for perinatal care in northwest London. Sixty-five women were referred to our fetal medicine centre, between 2012-2016, with IVF conceived multiple pregnancies. INCLUSION CRITERIA: In Vitro fertilisation and conception of twins/ triplets/quadruplets...
July 2019: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/31038903/aromatase-inhibitors-such-as-letrozole-femara-vs-clomiphene-clomid-for-subfertile-women-with-pcos
#13
JOURNAL ARTICLE
Nicholas LeFevre
No abstract text is available yet for this article.
May 1, 2019: American Family Physician
https://read.qxmd.com/read/30553050/double-mild-stimulation-and-egg-collection-in-the-same-cycle-for-management-of-poor-ovarian-responders
#14
JOURNAL ARTICLE
T Madani, M Hemat, A Arabipoor, S H Khodabakhshi, Z Zolfaghari
PURPOSE: To evaluate the effect of double stimulations during the follicular and luteal phases in women with poor ovarian response (POR) in in-vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles. BASIC PROCEDURES: This prospective clinical study was performed in Royan Institute from October 2014 to January 2016. 121 patients were diagnosed as POR on the basis of Bologna criteria were included. Double stimulations were performed during the follicular and luteal phases by Letrozole, Clomid, hMG and GnRH-agonist...
May 2019: Journal of Gynecology Obstetrics and Human Reproduction
https://read.qxmd.com/read/30254944/endometriosis-involving-the-sciatic-nerve-a-case-report-of-isolated-endometriosis-of-the-sciatic-nerve-and-review-of-the-literature
#15
JOURNAL ARTICLE
Tal D Saar, Stefaan Pacquée, Dean Helmar Conrad, Mikhail Sarofim, Philippe De Rosnay, David Rosen, Greg Cario, Danny Chou
Endometriosis is a common gynecological condition which affects 5-10% of women of reproductive age and up to 50% of women with pelvic pain and infertility. The most commonly affected areas are the pelvic peritoneum, ovaries and rectovaginal septum. Isolated endometriosis of the sciatic nerve is very rare. Our patient suffered from worsening right hip and buttock pain with severe exacerbation during menstruation. Several different imaging modalities (ultrasound of her pelvis and right hip, as well as X-rays and computed tomography scans of her right hip and lumbosacral spine) failed to identify any pathology...
April 2018: Gynecology and Minimally Invasive Therapy
https://read.qxmd.com/read/30087721/assessment-of-laser-biostimulation-in-induction-of-ovulation
#16
JOURNAL ARTICLE
Mohamed A El-Nourya, Mahmoud B El-Begawyb, Mona E Morsyc, Ehab M Al Sherbineyd
AIM: This study aimed to evaluate a new modality of low power laser biostimulation in rat ovaries, in comparison with the conventional medical therapy by clomiphene citrate that depends on up-regulation of the hypothalamic-pituitary-ovarian axis to induce ovulation. STUDY DESIGN: A Prospective experimental study carried out from January 2014 to February 2016. SETTING: University-based photobiology laboratory. MATERIALS AND METHODS: Seventy-two (72) Female-Wistar Albino rats were used in this study, divided into three groups: 17 rats used as a control group, 19 rats received clomiphene citrate (Clomid group), 36 rats exposed to diode laser 660 nm wavelength (laser group)...
July 20, 2018: Open Access Macedonian Journal of Medical Sciences
https://read.qxmd.com/read/27536705/four-thrombotic-events-over-5-years-two-pulmonary-emboli-and-two-deep-venous-thrombosis-when-testosterone-hcg-therapy-was-continued-despite-concurrent-anticoagulation-in-a-55-year-old-man-with-lupus-anticoagulant
#17
JOURNAL ARTICLE
Charles J Glueck, Kevin Lee, Marloe Prince, Vybhav Jetty, Parth Shah, Ping Wang
BACKGROUND: When exogenous testosterone or treatments to elevate testosterone (human chorionic gonadotropin [HCG] or Clomid) are prescribed for men who have antecedent thrombophilia, deep venous thrombosis and pulmonary embolism often occur and may recur despite adequate anticoagulation if testosterone therapy is continued. CASE PRESENTATION: A 55-year-old white male was referred to us because of 4 thrombotic events, 3 despite adequate anticoagulation over a 5-year period...
July 2016: Journal of Investigative Medicine High Impact Case Reports
https://read.qxmd.com/read/27366008/the-risk-factors-and-pregnancy-outcomes-of-48-cases-of-heterotopic-pregnancy-from-a-single-center
#18
JOURNAL ARTICLE
Ji Hyun Jeon, Yu Im Hwang, Im Hee Shin, Chan Woo Park, Kwang Moon Yang, Hye Ok Kim
The purpose of this study was to investigate risk factors that are associated with heterotopic pregnancy (HP) following in vitro fertilization (IVF)-embryo transfer (ET) and to demonstrate the outcomes of HP after the surgical treatment of ectopic pregnancies. Forty-eight patients from a single center, who were diagnosed with HP between 1998 and 2012 were included. All of the patients had received infertility treatments, such as Clomid with timed coitus (n = 1, 2.1%), superovulation with intrauterine insemination (n = 7, 14...
July 2016: Journal of Korean Medical Science
https://read.qxmd.com/read/25930512/clomid-compared-with-follicle-stimulating-hormone-treatment-similar-follicle-number-means-different-success-rates-178
#19
Anatte Emma Karmon, Eden Rebecca Cardozo, John Christopher Petrozza
INTRODUCTION: Clomiphene citrate and gonadotropins are used during intrauterine insemination cycles to help recruit one or more follicles. The objective of this study is to evaluate whether one treatment confers a higher pregnancy rate over the other, even when number of preovulatory follicles are held constant. METHODS: Data from 1,463 women who underwent 3,960 clomiphene or gonadotropin intrauterine insemination cycles were reviewed. Cycles occurred at Massachusetts General Hospital between 2004 and 2012...
May 2015: Obstetrics and Gynecology
https://read.qxmd.com/read/25356081/the-correlation-of-factors-affecting-the-endometrial-thickness-with-pregnancy-outcome-in-the-iui-cycles
#20
JOURNAL ARTICLE
Victoria Habibzadeh, Sayed Noureddin Nematolahi Mahani, Hadiss Kamyab
BACKGROUND: Many studies have been carried out to understand the effect of endometrial thickness on the reproductive outcome while the factors affecting the pattern itself are still unknown. OBJECTIVE: To determine the factors such as age and the number of follicles that could affect the endometrial thickness Materials and Methods: This study was conducted as a retrospective study on 680 infertile women considered for intrauterine insemination (IUI). IUI protocol was sequential regimen of clomid and gonadotropin...
2011: Iranian Journal of Reproductive Medicine
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