keyword
MENU ▼
Read by QxMD icon Read
search

Hif lung

keyword
https://www.readbyqxmd.com/read/29645000/neotuberostemonine-inhibits-the-differentiation-of-lung-fibroblasts-into-myofibroblasts-in-mice-by-regulating-hif-1%C3%AE-signaling
#1
Xin-Miao Lv, Ming-Dan Li, Si Cheng, Bao-Lin Liu, Kang Liu, Chao-Feng Zhang, Xiang-Hong Xu, Mian Zhang
Pulmonary fibrosis may be partially the result of deregulated tissue repair in response to chronic hypoxia. In this study we explored the effects of hypoxia on lung fibroblasts and the effects of neotuberostemonine (NTS), a natural alkaloid isolated from Stemona tuberosa, on activation of fibroblasts in vitro and in vivo. PLFs (primary mouse lung fibroblasts) were activated and differentiated after exposure to 1% O2 or treatment with CoCl2 (100 μmol/L), evidenced by markedly increased protein or mRNA expression of HIF-1α, TGF-β, FGF2, α-SMA and Col-1α/3α, which was blocked after silencing HIF-1α, suggesting that the activation of fibroblasts was HIF-1α-dependent...
April 12, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29629903/zmynd8-acetylation-mediates-hif-dependent-breast-cancer-progression-and-metastasis
#2
Yan Chen, Bo Zhang, Lei Bao, Lai Jin, Mingming Yang, Yan Peng, Ashwani Kumar, Jennifer E Wang, Chenliang Wang, Xuan Zou, Chao Xing, Yingfei Wang, Weibo Luo
Altered epigenetic reprogramming contributes to breast cancer progression and metastasis. How the epigenetic reader mediates breast cancer progression remains poorly understood. Here, we showed that the epigenetic reader zinc finger MYND-type containing 8 (ZMYND8) is induced by HIF-1 and HIF-2 in breast cancer cells and also upregulated in human breast tumors, and is correlated with poor survival of patients with breast cancer. Genetic deletion of ZMYND8 decreases breast cancer cell colony formation, migration, and invasion in vitro, and inhibits breast tumor growth and metastasis to the lungs in mice...
April 9, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29621765/nrf2-activation-induced-by-sirt1-ameliorates-acute-lung-injury-after-intestinal-ischemia-reperfusion-through-nox4-mediated-gene-regulation
#3
DongDong Chai, Lei Zhang, SiWei Xi, YanYong Cheng, Hong Jiang, Rong Hu
BACKGROUND/AIMS: Nuclear erythroid 2-related factor-2 (Nrf2) is a major stress-response transcription factor that has been implicated in regulating ischemic angiogenesis. We investigated the effects of Nrf2 in regulating revascularization and modulating acute lung injury. METHODS: The expression of Nrf2 and sirtuin1 (Sirt1) was assessed in lung tissue by western blotting and immunofluorescence staining after intestinal ischemia/reperfusion (IIR) in Nrf2-/- and wild-type (WT) mice...
March 29, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29616117/correlation-of-hypoxia-status-with-radiosensitizing-effects-of-sodium-glycididazole-a-preclinical-study
#4
Yang Yu, Xiaolin Li, Hengwei Xu, Jing Liu, Min Dong, Jia Yang, Lu Sun, Xiaorong Sun, Ligang Xing
The correlation of pretreatment hypoxia status with the radiosensitization effect of sodium glycididazole (CMNa) was not previously defined. The purpose of the present study was to evaluate the tumor hypoxia status in various cancer xenografts and to investigate the correlation between tumor hypoxia status and radiosensitizing effects of CMNa based on the pharmacokinetic and pharmacodynamic parameters. Human esophageal cancer (EC109), head and neck cancer (FaDu) and lung cancer (A549) nude mice xenografts were used...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29608508/tumor-heterogeneity-hypoxia-and-immune-markers-in-surgically-resected-non-small-cell-lung-cancer
#5
Angelo Castello, Fabio Grizzi, Luca Toschi, Sabrina Rossi, Daoud Rahal, Federica Marchesi, Carlo Russo, Giovanna Finocchiaro, Egesta Lopci
OBJECTIVES: This study aimed to determine the prognostic role of textural features and their association with metabolic parameters, hypoxia, and cancer-related immune markers in non-small-cell lung cancer (NSCLC) patients. PATIENTS AND METHODS: The trial was registered at http://www.clinicaltrials.gov (NCT02519062). From January 2010 to May 2014, 44 patients (male : female=33 : 11; median age: 69.5 years), referred to our Institution for NSCLC resection, were enrolled...
March 30, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29570987/role-of-egcg-in-containing-the-progression-of-lung-tumorigenesis-a-multistage-targeting-approach
#6
Sunil Kumar Dhatwalia, Manoj Kumar, Devinder K Dhawan
Lung cancer is a prominent form among various types of cancers, irrespective of the sex worldwide. Treatment of lung cancer involves the intensive phase of chemotherapy/radiotherapy which is associated with high rate of adverse events. There is a need of safe and reliable treatment/adjunctive therapy to apprehend the cancer by reducing the undesirable outcome of primary therapy. Epigallocatechin-3-gallate (EGCG), which is a potent antioxidant and anticancer compound extracted from the plant camellia sinensis has proved to be a novel agent to control or reduce lung tumorigenesis by affecting the signaling molecules of cell cycle regulation and apoptotic pathways...
March 23, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29568362/the-metal-nonoate-ni-salpipnono-inhibits-in-vitro-tumor-growth-invasiveness-and-angiogenesis
#7
Valerio Ciccone, Martina Monti, Enrico Monzani, Luigi Casella, Lucia Morbidelli
Nitric oxide (NO) exerts conflicting effect on tumor growth and progression, depending on its concentration. We aimed to characterize the anti-cancer activity of a new NO donor, Ni(SalPipNONO) belonging to the class of metal-nonoates, in epithelial derived tumor cells, finally exploring its antiangiogenic properties. Tumor epithelial cells were screened to evaluate the cytotoxic effect of Ni(SalPipNONO), which was able to inhibit cell proliferation in a dose dependent manner, being more effective than the commercial DETA/NO...
March 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29560113/hypoxic-induced-truncation-of-voltage-dependent-anion-channel-1-is-mediated-by-both-asparagine-endopeptidase-and-calpain-1-activities
#8
Hadas Pahima, Simona Reina, Noa Tadmor, Daniella Dadon-Klein, Anna Shteinfer-Kuzmine, Nathalie M Mazure, Vito De Pinto, Varda Shoshan-Barmatz
The voltage-dependent anion channel 1 (VDAC1), an outer mitochondria membrane (OMM) protein, serves as a mitochondrial gatekeeper, mediating the transport of nucleotides, Ca2+ and other metabolites across the OMM. VDAC1 also plays a central role in mitochondria-mediated apoptosis by facilitating the release of apoptotic proteins and by association with both pro- and anti-apoptotic proteins. Tumor cells, which are constantly exposed to hypoxic conditions, affect the cell via the transcription factor hypoxia-inducible factor (HIF) that induces transcriptional activity...
February 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29559116/biology-of-clinical-strains-of-mycobacterium-tuberculosis-with-varying-levels-of-transmission
#9
Crystal A Shanley, Marcela I Henao-Tamayo, Chand Bipin, Raja Mugasimangalam, Deepshika Verma, Diane J Ordway, Elizabeth M Streicher, Ian M Orme
Transmission of Mycobacterium tuberculosis bacilli from one individual to another is the basis of the disease process. While considerable emphasis has been placed on the role of host mechanisms of resistance in establishing or preventing new infection, far less has been expended on understanding possible factors operative at the bacterial level. In this study we established a panel of clinical isolates of M. tuberculosis strains obtained from the Western Cape region of South Africa, each of which had been carefully tracked in terms of their degree of transmission in the community...
March 2018: Tuberculosis
https://www.readbyqxmd.com/read/29550861/respiratory-hazard-of-li-ion-battery-components-elective-toxicity-of-lithium-cobalt-oxide-licoo-2-particles-in-a-mouse-bioassay
#10
Violaine Sironval, Laurence Reylandt, Perrine Chaurand, Saloua Ibouraadaten, Mihaly Palmai-Pallag, Yousof Yakoub, Bernard Ucakar, Jérôme Rose, Claude Poleunis, Rita Vanbever, Etienne Marbaix, Dominique Lison, Sybille van den Brule
Rechargeable Li-ion batteries (LIB) are increasingly produced and used worldwide. LIB electrodes are made of micrometric and low solubility particles, consisting of toxicologically relevant elements. The health hazard of these materials is not known. Here, we investigated the respiratory hazard of three leading LIB components (LiFePO4 or LFP, Li4 Ti5 O12 or LTO, and LiCoO2 or LCO) and their mechanisms of action. Particles were characterized physico-chemically and elemental bioaccessibility was documented. Lung inflammation and fibrotic responses, as well as particle persistence and ion bioavailability, were assessed in mice after aspiration of LIB particles (0...
March 17, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29531823/sotetsuflavone-suppresses-invasion-and-metastasis-in-non-small-cell-lung-cancer-a549-cells-by-reversing-emt-via-the-tnf-%C3%AE-nf-%C3%AE%C2%BAb-and-pi3k-akt-signaling-pathway
#11
Shaohui Wang, Yu Yan, Zhekang Cheng, Yanlan Hu, Tongxiang Liu
Epithelial-mesenchymal transition (EMT) is associated with tumor invasion and metastasis, and offers insight into novel strategies for cancer treatment. Sotetsuflavone was isolated from Cycas revolute , which has excellent anticancer activity in the early stages. The present study aims to evaluate the anti-metastatic potential of sotetsuflavone in vitro. Our data demonstrated that sotetsuflavone inhibits metastasis of A549 cells, and EMT. This inhibition was reflected in the upregulation of E-cadherin, and downregulation of N-cadherin, vimentin, and Snail...
December 2018: Cell Death Discovery
https://www.readbyqxmd.com/read/29515232/tet2-dependent-il-6-induction-mediated-by-the-tumor-microenvironment-promotes-tumor-metastasis-in-osteosarcoma
#12
Hitoshi Itoh, Tsuyoshi Kadomatsu, Hironori Tanoue, Masaki Yugami, Keishi Miyata, Motoyoshi Endo, Jun Morinaga, Eisuke Kobayashi, Takeshi Miyamoto, Ryoma Kurahashi, Kazutoyo Terada, Hiroshi Mizuta, Yuichi Oike
The tumor microenvironment promotes epigenetic changes in tumor cells associated with tumor aggressiveness. Here we report that in primary tumor cells, increased interleukin-6 (IL-6) expression brought on by DNA demethylation of its promoter by ten-eleven translocation 2 (TET2) promotes lung metastasis in osteosarcoma (OS). Xenograft experiments show increased IL-6 expression and decreased methylation of its promoter in OS cells after implantation relative to before implantation. In addition, changes in IL-6 methylation and expression seen in OS cells at the primary site were maintained at the metastatic site...
March 8, 2018: Oncogene
https://www.readbyqxmd.com/read/29501934/progesterone-attenuates-airway-remodeling-and-glucocorticoid-resistance-in-a-murine-model-of-exposing-to-ozone
#13
Xue Zhang, Wuping Bao, Xia Fei, Yingying Zhang, Guoqing Zhang, Xin Zhou, Min Zhang
Airway remodeling is a vital component of chronic obstructive pulmonary disease (COPD). Despite the broad anti-inflammation effects of glucocorticoids, they exhibit relatively little therapeutic benefit in COPD, indicating the accelerating demands of new agents for COPD. We aim to explore the effect of progesterone on airway remodeling in a murine modeling of exposing to ozone and to further examine the potential effect of progesterone on glucocorticoid insensitivity. C57/BL6 mice were exposed to ozone for 12 times over 6 weeks, and were administered with progesterone alone or combined with budesonide (BUD) after each exposure until the 10th week...
March 1, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29501572/involvement-of-hif-1%C3%AE-regulated-mir-21-acting-via-the-akt-nf-%C3%AE%C2%BAb-pathway-in-malignant-transformation-of-hbe-cells-induced-by-cigarette-smoke-extract
#14
Lu Lu, Hui Xu, Ping Yang, Junchao Xue, Chao Chen, Qian Sun, Qianlei Yang, Jiachun Lu, Aimin Shi, Qizhan Liu
Although the relationship between cigarette smoke and lung cancer has been widely studied, the molecular mechanism for cigarette smoke-induced lung cancer remains largely unclear. The present study investigated the roles of hypoxia-inducible factor (HIF)-1α and miR-21 in the malignant transformation of human bronchial epithelial (HBE) cells induced by cigarette smoke extract (CSE). In case of acute and chronic treatment of HBE cells, CSE increased the levels of HIF-1α, p-Akt, p-NF-κB, and miR-21 and decreased PTEN levels...
February 28, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29477471/ruscogenin-suppressed-the-hepatocellular-carcinoma-metastasis-via-pi3k-akt-mtor-signaling-pathway
#15
Hui Hua, Yu Zhu, Yu-He Song
BACKGROUND: Hepatocellular carcinoma (HCC) is the third-leading cause of cancer-related mortality with poor prognosis and treatment. More effective strategies should be studied in HCC. METHODS: After treated with ruscogenin, the cell proliferation was assessed by CCK-8 method. Cell migration and invasion were estimated using wound healing and transwell assays. Pathological changes of lung tissue were observed by HE staining and IHC methods. MMP-2, MMP-9, uPA, VEGF and HIF-1α levels were measured using ELISA, RT-qPCR and WB tests...
February 22, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29469087/downregulation-of-hif-2%C3%AE-reverse-the-chemotherapy-resistance-of-lung-adenocarcinoma-a549-cells-to-cisplatin
#16
Zhao-Jia Gao, Wei-Dong Yuan, Jun-Qiang Yuan, Kai Yuan, Yong Wang
BACKGROUND Cisplatin (DDP)-based systemic chemotherapy has been widely used in the treatment of postoperative or advanced NSCLC patients, however, its effective rate is only 14~40%. HIF-2α can upregulate drug-resistant-related genes expression and lead to chemotherapy resistance in many tumors. However, little is known about the relationship between HIF-2α and chemotherapy resistance of lung cancer cells. MATERIAL AND METHODS In our study, the siRNA expression vectors targeting the HIF-2α gene were designed, constructed, and transfected into A549 cells...
February 22, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29467870/hif-1%C3%AE-promotes-zeb1-expression-and-emt-in-a-human-bladder-cancer-lung-metastasis-animal-model
#17
Jianning Zhu, Zhixin Huang, Mengzhao Zhang, Weiyi Wang, Hua Liang, Jin Zeng, Kaijie Wu, Xinyang Wang, Jer-Tsong Hsieh, Peng Guo, Jinhai Fan
Lung is one of the most common sites for bladder cancer to metastasize. Although the involvement of the epithelial-to-mesenchymal transition (EMT) in bladder cancer progression has been established, the mechanism of EMT induction remains unclear. In order to investigate this, T24-parental (P) and T24-lung (L) bladder cancer cells were obtained from primary tumors and lung metastatic sites of an animal model with orthotopic spontaneous metastatic bladder cancer, according to a protocol previously described. Compared with T24-P cells, mesenchymal-like T24-L cells exhibited an increased ability in tumor invasion and metastasis, as well as an increased expression of hypoxia-inducible factor (HIF)-1α, zinc finger E-box-binding homeobox 1 (ZEB1), vimentin and N-cadherin and lower level of cytokeratin 18 were observed...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29454386/telomere-elongation-protects-heart-and-lung-tissue-cells-from-fatal-damage-in-rats-exposed-to-severe-hypoxia
#18
Yaping Wang, Zhen Zhao, Zhiyong Zhu, Pingying Li, Xiaolin Li, Xiaohong Xue, Jie Duo, Yingcai Ma
BACKGROUND: The effects of acute hypoxia at high altitude on the telomere length of the cells in the heart and lung tissues remain unclear. This study aimed to investigate the change in telomere length of rat heart and lung tissue cells in response to acute exposure to severe hypoxia and its role in hypoxia-induced damage to heart and lung tissues. METHODS: Forty male Wistar rats (6-week old) were randomized into control group (n = 10) and hypoxia group (n = 30)...
February 17, 2018: Journal of Physiological Anthropology
https://www.readbyqxmd.com/read/29435131/pd-l1-confers-resistance-to-egfr-mutation-independent-tyrosine-kinase-inhibitors-in-non-small-cell-lung-cancer-via-upregulation-of-yap1-expression
#19
Jai-Nien Tung, Po-Lin Lin, Yao-Chen Wang, De-Wei Wu, Chi-Yi Chen, Huei Lee
Programmed death ligand (PD-L1) expression was associated with tumor immune escape and subsequent poor prognosis in non-small cell lung cancer (NSCLC). This expression was higher in patients with EGFR-mutated NSCLC tumors than in those with EGFR-wild-type (WT) NSCLC tumors. We therefore hypothesized that poor prognosis mediated by higher PD-L1 may be partially through conferring resistance to tyrosine kinase inhibitor (TKI) in NSCLC regardless of EGFR mutation. The change in PD-L1 expression following gene manipulation corresponded with changes in expression of HIF-1α and YAP1...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29434884/endostatin-reverses-immunosuppression-of-the-tumor-microenvironment-in-lung-carcinoma
#20
Xiaolin Liu, Weiwei Nie, Qi Xie, Guoling Chen, Xingyu Li, Yanrui Jia, Beibei Yin, Xun Qu, Yan Li, Jing Liang
Endostatin has previously been demonstrated to efficiently inhibit the angiogenesis and growth of endothelial cells. However, the role of endostatin in the tumor microenvironment remains to be elucidated. To investigate the antitumor effect of endostatin in lung cancer, the present study was designed to explore the alterations of microvessel density in Lewis lung cancer models and the expression of vascular endothelial growth factor (VEGF), interleukin (IL)-6, IL-17, interferon (IFN)-γ and hypoxia inducible factor (HIF)-1α, following endostatin therapy...
February 2018: Oncology Letters
keyword
keyword
25586
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"