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Lin Yao, Xinjun Sheng, Natalie Mrachacz-Kersting, Xiangyang Zhu, Dario Farina, Ning Jiang
OBJECTIVE: We propose a novel calibration strategy to facilitate the decoding of covert somatosensory attention by exploring the oscillatory dynamics induced by tactile sensation. METHODS: It was hypothesized that the similarity of the oscillatory pattern between stimulation sensation (SS, real sensation) and somatosensory attentional orientation (SAO) provides a way to decode covert somatic attention. Subjects were instructed to sense the tactile stimulation, which was applied to the left (SS-L) or the right (SS-R) wrist...
October 12, 2017: IEEE Transactions on Bio-medical Engineering
Narges Johari, Hamid Reza Madaah Hosseini, Ali Samadikuchaksaraei
It is known that Fluoride ions strongly affect bone mineralization and formation. In the present study, the engineered bone tissue scaffolds are fabricated using silk fibroin (SF) and flouridated TiO2 nanoparticles. TiO2 nanoparticles are modified by fluoride ions, and different levels (0, 5, 10, 15 and 20wt%) of the fluoridated TiO2 nanoparticles (TiO2-F) were subsequently added to the SF matrix through phase separation method to prepare silk fibroin/flouridated TiO2 nanocomposite scaffolds (SF/TiO2-F). Phase structure, functional groups, morphology and mechanical properties of the obtained scaffolds were evaluated by X-ray diffraction method (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and compressive testing, respectively...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Jennifer M Mundt, Stephan Eisenschenk, Michael E Robinson
Objective: Short sleep duration and insomnia have been linked to higher pain and an increased risk of developing chronic pain, but relatively little research has examined the contribution of sleep disordered breathing (SDB) to pain. This study examined the unique contributions of SDB and insomnia to chronic pain. Subjects: Adult patients referred to an academic sleep center for overnight polysomnography were invited to participate. Methods: Participants (N = 105) completed questionnaires about their sleep and pain, including the Insomnia Severity Index, Medical College of Virginia Pain Questionnaire, and two weeks of sleep/pain diaries...
August 28, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Zhijun Chen, Raweewan Thiramanas, Mischa Schwendy, Chaoming Xie, Sapun H Parekh, Volker Mailänder, Si Wu
Enzyme activity is important for metabolism, cell functions, and treating diseases. However, remote control of enzyme activity in deep tissue remains a challenge. This study demonstrates near-infrared (NIR) light-regulated enzyme activity in living cells based on upconverting nanoparticles (UCNPs) and a photoactivatable Ru complex. The Ru complex is a caged enzyme inhibitor that can be activated by blue light. To prepare a nanocarrier for NIR photoinhibition of enzyme activity, a UCNP and the caged enzyme inhibitors are encapsulated in a hollow mesoporous silica nanoparticle...
October 12, 2017: Small
Rodrigo Dal Ben, Fernanda Castanho Calixto, André Luiz Ferreira
Recent studies have stressed the importance of disseminating behavior analysis to a more diverse audience and have provided ways to do so effectively. General science publications offer an attractive venue for communicating with a scientifically educated public. The present study examines behavior analysis research published in Science Today and Research Fapesp, monthly general science publications published by the Brazilian Society for the Advancement of Science and São Paulo Research Foundation, respectively...
September 2017: Behavior Analysis in Practice
Gustavo Pilotto Domingues Sá, Jorge Roberto Marcante Carlotto, Fernando Pompeu Piza Vicentine, Luiz Romero, Dario Fernandes Perdomo Tejada, Alcides Augusto Salzedas, Gaspar de Jesus Lopes, Adriano Miziara Gonzalez
OBJECTIVE: to compare the outcome of liver transplantation for hepatocarcinoma in submitted or not to locoregional treatment and downstaging regarding survival and risk of recurrence in transplant waiting list patients. METHODS: retrospective study of patients with hepatocarcinoma undergoing liver transplantation in the metropolitan region of São Paulo, between January 2007 and December 2011, from a deceased donor. The sample consisted of 414 patients. Of these, 29 patients were included in the list by downstaging...
July 2017: Revista do Colégio Brasileiro de Cirurgiões
Eliana Bittar, Valéria Castilho
OBJECTIVE: Identifying the average direct cost of TAVI (Transcatheter Aortic Valve Implantation) for the different access routes. METHOD: This is a research with a quantitative, exploratory and descriptive approach carried out in a government teaching hospital in the state of São Paulo. RESULTS: The average direct cost of TAVI procedures by the access routes resulted in R$82,826.38 (transfemoral route), R$79,440.91 (transaortic route) and R$78,173...
October 9, 2017: Revista da Escola de Enfermagem da U S P
Mariane Henriques França, Sandhi Maria Barreto, Flavia Garcia Pereira, Laura Helena Silveira Guerra de Andrade, Maria Cristina Alochio de Paiva, Maria Carmen Viana
Mental disorders are associated with employment status as significant predictors and as consequences of unemployment and early retirement. This study describes the estimates and associations of 12-month DSM-IV prevalence rates of mental disorders and use of health services with employment status by gender in the São Paulo Metropolitan Area, Brazil. Data from the São Paulo Megacity Mental Health Survey was analyzed (n = 5,037). This is a population-based study assessing the prevalence and determinants of mental disorders among adults, using the Composite International Diagnostic Interview...
October 9, 2017: Cadernos de Saúde Pública
Carolina Bertagnoli Volpe, Maria Luiza Blanques Petty, Altay Alves Lino de Souza, Maria Arlete Meil Schimith Escrivão
This study aimed to compare answers given by parents and their adolescent children to the Portuguese version of the Parent Mealtime Action Scale (PMAS) and to assess associations among the reported behaviors. To compare these answers, a cross-sectional study was conducted in a sample of 72 patients of the Obesity Clinic of the Division of Nutrology of the Pediatrics Department at the Federal University of São Paulo (Unifesp), Brazil. These patients were aged from 10 years to 19 years and 11 months, and their parents or legal guardians also participated...
October 6, 2017: Appetite
Laís Amaral Mais, Sarah Warkentin, Juliana Bergamo Vega, Maria do Rosário Dias de Oliveira Latorre, Susan Carnell, José Augusto de Aguiar Carrazedo Taddei
OBJECTIVE: The present study aimed to identify food patterns among 2-9-year-olds and investigate sociodemographic, anthropometric and behavioural predictors of less healthy dietary patterns. DESIGN: Cross-sectional study. Parents of 2-9-year-olds completed an FFQ and factor analysis was applied to identify dietary patterns. Parents also completed questionnaires assessing sociodemographic, anthropometric and behavioural characteristics of parents and children, including parental feeding practices...
October 9, 2017: Public Health Nutrition
Ayano Mise, Yuta Yoshino, Kiyohiro Yamazaki, Yuki Ozaki, Tomoko Sao, Taku Yoshida, Takaaki Mori, Yoko Mori, Shinichiro Ochi, Jun-Ichi Iga, Shu-Ichi Ueno
BACKGROUND: TOMM40 is located on chromosome 19, is in linkage disequilibrium with apolipoprotein E (APOE), andis reported in several genome-wide association studies to be associated with Alzheimer's disease (AD). OBJECTIVE: Assess APOE and TOM40 and mitochondrial genes as blood biomarkers for AD. METHODS: We examined TOMM40, PTEN-induced putative kinase 1 (PINK1), Parkin RBR E3 ubiquitin protein ligase (PARK2), and APOE mRNA expression in relation to the methylation rates of CpG sites in the upstream region of TOMM40exon 1 in peripheral leukocytes and TOMM40523 polyT genotypes in 60 AD and age- and sex-matched control subjects...
2017: Journal of Alzheimer's Disease: JAD
Xiangbo Lin, Lijun Wang, Faming Wang
Osteosarcoma is the most common type of bone cancer, and accounts for ~3% of cancers that occurring in children. Chondromodulin‑I (ChM-I) is a 25 kDa glycoprotein that is expressed mainly in cartilage. ChM-I demonstrates anti‑angiogenic activity and has been suggested to inhibit endothelial cells from invading cartilage, and then has been shown to be an inhibitor of tumorigenesis. However, it remains unclear if ChM‑I has any direct anti‑tumorigenesis role on osteosarcoma. Therefore, the present study aimed to identify whether ChM‑I has any direct inhibit effect on human osteosarcoma cells...
September 26, 2017: Molecular Medicine Reports
Vera M S Belangero, Liliane C Prates, Andreia Watanabe, Benita S G Schvartsman, Paula Nussenzveig, Natalia A Cruz, Ana L S Abreu, Isabel P Paz, Inalda Facincani, Fernanda E C Morgantetti, Andreia O Silva, Olberes V B Andrade, Maria F C Camargo, Paulo C Koch Nogueira
OBJECTIVE: To identify risk factors for chronic kidney disease (CKD) progression in Brazilian children and to evaluate the interactions between factors. METHODS: This was a multicenter prospective cohort in São Paulo, involving 209 children with CKD stages 3-4. The study outcome included: (a) death, (b) start of kidney replacement therapy, (c) eGFR decrease >50% during the followup. Thirteen risk factors were tested using univariate regression models, followed by multivariable Cox regression models...
October 2, 2017: Jornal de Pediatria
Gabriel Messias Moura de Faria, Giulliana Mondelli
Leachate contamination is a chronic and urgent problem present in municipal solid waste (MSW) landfill. Geochemical mathematical models in this work was suitable to study the dynamics of the leachate from an MSW landfill located in the Midwest of Sao Paulo, Brazil, a region with high precipitation and temperature and rich in chalcophile compounds and lithophile compounds, despite contamination with nitrogenous compounds. After 13 years of local aquifer monitoring, some groundwater samplings in Feb. 2004, Aug...
October 5, 2017: Environmental Science and Pollution Research International
Angélica B Ferreira, Andreza P Ribeiro, Maurício L Ferreira, Cláudia T Kniess, Cristiano C Quaresma, Raffaele Lafortezza, José O Santos, Mitiko Saiki, Paulo H Saldiva
Industrialization in developing countries associated with urban growth results in a number of economic benefits, especially in small or medium-sized cities, but leads to a number of environmental and public health consequences. This problem is further aggravated when adequate infrastructure is lacking to monitor the environmental impacts left by industries and refineries. In this study, a new protocol was designed combining biomonitoring and geostatistics to evaluate the possible effects of shale industry emissions on human health and wellbeing...
2017: Frontiers in Plant Science
Ana Paula Ghussn Cano, Mariana Tresoldi Neves Romaneli, Ricardo Mendes Pereira, Antonia Teresinha Tresoldi
OBJECTIVE: To describe clinical, radiological, epidemiological, and microbiological characteristics of pediatric patients with diagnosis of tuberculosis in a period of 15 years. METHODS: Retrospective study including children and adolescents younger than 18 years diagnosed with tuberculosis in the Clinical Hospital of the Universidade Estadual de Campinas in São Paulo State, Brazil. Active tuberculosis was defined by the identification of Mycobacterium tuberculosis in culture, microscopy, or histopathological examination...
April 2017: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
Eduardo Rossato de Victo, Gerson Luis de Moraes Ferrari, João Pedro da Silva, Timóteo Leandro Araújo, Victor Keihan Rodrigues Matsudo
OBJECTIVE: To evaluate the lifestyle indicators associated with cardiorespiratory fitness in adolescents from Ilhabela, São Paulo, Brazil. METHODS: The sample consisted of 181 adolescents (53% male) from the Mixed Longitudinal Project on Growth, Development, and Physical Fitness of Ilhabela. Body composition (weight, height, and body mass index, or BMI), school transportation, time spent sitting, physical activity, sports, television time (TV), having a TV in the bedroom, sleep, health perception, diet, and economic status (ES) were analyzed...
January 2017: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
Henrique Willian Cosme, Laura Silva Lima, Lene Garcia Barbosa
OBJECTIVE: To study the prevalence of congenital anomalies in newborns in the city of São Paulo from 2010 to 2014, as well as to analyze other variables associated with the anomalies. METHODS: Data was collected from the Ministry of Health's Live Births Information System (SINASC) from 2010 to 2014 in São Paulo City. The variables analyzed were length and type of pregnancy, maternal age, and ethnicity and sex of the newborn. The absolute and relative frequencies of congenital anomalies were verified, and the variables associated with them were calculated with the odds ratio (OR) and a 95% confidence interval...
January 2017: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
Renata Cristina Guskuma, Vinícius Aguiar Lages, Maylu Botta Hafner, Maria Paula Maciel Rando-Meirelles, Silvia Cypriano, Maria da Luz Rosário de Sousa, Marília Jesus Batista
OBJECTIVE: The aim of this study was to evaluate the prevalence and intensity of dental pain in children according to size of municipality, associated factors and absenteeism. METHODS: The sample consisted of children aged 12 years old from public and private schools drawn from eight cities in the region of Campinas (SP). A questionnaire was applied to obtain dental pain, demographic, socioeconomic data, and a clinical examination was carried out to evaluate the experience of having a cavity...
July 2017: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
Camila Helen de Oliveira Bettiol, Mara Solange Gomes Dellaroza, Maria Lúcia Lebrão, Yeda Aparecida Duarte, Hellen Geremias Dos Santos
: The objective was to identify predictors of pain in the elderly. This was a longitudinal population-based study using home interviews with elderly residing in the city of São Paulo, Brazil, and participating in the SABE Study in 2006 and 2010. Analysis of predictors of pain used hierarchical logistic regression, based on a theoretical-conceptual model with distal, intermediate, and proximal variables. Accumulated pain incidence was 27.9%. After adjustments, predictors of pain in the elderly were: 0 to 3 years of schooling (OR = 2...
September 28, 2017: Cadernos de Saúde Pública
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