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https://www.readbyqxmd.com/read/29474747/microrna-134-inhibits-osteosarcoma-angiogenesis-and-proliferation-by-targeting-the-vegfa-vegfr1-pathway
#1
Long Zhang, Zhi Lv, Jing Xu, Chenglong Chen, Qiaofeng Ge, Pengcui Li, Dinglu Wei, Zhuangzhuang Wu, Xiaojuan Sun
The vascular endothelial growth factor (VEGF) A and vascular endothelial growth factor receptor 1 (VEGFR1) signaling is crucial for angiogenesis and progression of osteosarcoma (OS). However, the regulation of the VEGF/VEGFR1 expression is still unclear in OS. Here, we show lower levels of microRNA-134 (miR-134) in OS tissues and cells. Induction of miR-134 over-expression significantly reduced the proliferation of Saos-2 cells and their secretion of pro-angiogenic factors, but increased the frequency of apoptotic Saos-2 cells...
February 23, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29473324/establishment-and-characterization-of-in-vivo-orthotopic-bioluminescent-xenograft-models-from-human-osteosarcoma-cell-lines-in-swiss-nude-and-nsg-mice
#2
Maria Eugenia Marques da Costa, Estelle Daudigeos-Dubus, Anne Gomez-Brouchet, Olivia Bawa, Valerie Rouffiac, Massimo Serra, Katia Scotlandi, Conceição Santos, Birgit Geoerger, Nathalie Gaspar
Osteosarcoma is one of the most common primary bone tumors in childhood and adolescence. Metastases occurrence at diagnosis or during disease evolution is the main therapeutic challenge. New drug evaluation to improve patient survival requires the development of various preclinical models mimicking at best the complexity of the disease and its metastatic potential. We describe here the development and characteristics of two orthotopic bioluminescent (Luc/mKate2) cell-derived xenograft (CDX) models, Saos-2-B-Luc/mKate2-CDX and HOS-Luc/mKate2-CDX, in different immune (nude and NSG mouse strains) and bone (intratibial and paratibial with periosteum activation) contexts...
February 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29469009/dairy-consumption-and-inflammatory-profile-a-cross-sectional-population-based-study-s%C3%A3-o-paulo-brazil
#3
Tábata Natal Gadotti, Marina Maintinguer Norde, Marcelo Macedo Rogero, Mauro Fisberg, Regina Mara Fisberg, Erica Oki, Lígia Araújo Martini
OBJECTIVES: The aim of this study was to investigate the association between dairy product consumption and plasma inflammatory biomarkers levels among a representative sample of Brazilian adults from São Paulo City. METHODS: Data were acquired from the Health Survey for São Paulo, a cross-sectional population-based study. All individuals 20 to 59 y of age with complete food consumption information (24-h dietary recall and food frequency questionnaire) and blood sample analysis were included (N = 259)...
October 26, 2017: Nutrition
https://www.readbyqxmd.com/read/29468399/pedotransfer-functions-of-potentially-toxic-elements-in-tropical-soils-cultivated-with-vegetable-crops
#4
Alexys G F Boim, Sónia M Rodrigues, Sabrina N Dos Santos-Araújo, Eduarda Pereira, Luís R F Alleoni
The anthropogenic input of potentially toxic elements (PTEs) from industry, agrochemicals, etc., into the environment are of great concern. Models derived from pedotransfer functions can provide estimates of the levels of PTEs based on soil attributes. Based on the importance of these models in studies in contaminated areas, we assessed the concentrations of the reactive contents of Ba, Cu, Cr, Ni, Pb, and Zn in soils cultivated with vegetable crops in the state of São Paulo, Brazil. We also evaluated the influence of chemical and physical soil attributes on their reactivity and availability...
February 21, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29468346/drivers-of-sexual-inactivity-among-women-living-with-hiv-and-aids-findings-of-the-genih-study-in-s%C3%A3-o-paulo-brazil
#5
Adriana de Araujo Pinho, Regina Maria Barbosa, Sandra Brignol, Wilza Villela, Simone Souza Monteiro
The advances on HIV/AIDS diagnosis and treatment have enabled people living with HIV/AIDS (PLHA) better quality of life. However, the persistence of HIV-related stigma and discrimination, and the risks triggered by HIV disclosure, may be a barrier to the sexual exercise of PLHA. We investigated the prevalence of sexual inactivity and the reasons given for it among a representative sample of women of reproductive age living with HIV/AIDS (WLWHA) in the municipality of São Paulo, Brazil. We surveyed 918 WLWHA with probability proportional to average number of visits in each of the 18 referral HIV/AIDS services...
February 21, 2018: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/29467516/packed-red-blood-cells-transfusion-in-neonates-effect-on-fio-2-and-pao-2-sao-2-ratio-and-implications-for-neonatal-saturation-targeting
#6
Itamar Nitzan, Cathy Hammerman, Francis B Mimouni, Alona Bin-Nun
OBJECTIVE: To assess the effect of blood transfusions in neonates on partial pressure of oxygen in arterial blood (PaO2 ), arterial hemoglobin oxygen saturation (SaO2 ) and arterial hemoglobin oxygen saturation as measured by pulse oximetry (SpO2 ). STUDY DESIGN: Retrospective study of neonates that received a first blood transfusion while having an indwelling arterial line. We compared PaO2 , SaO2, SpO2, SaO2 /PaO2 ratio and fraction of inspired oxygen (FiO2 ) 12 h before and after blood transfusion...
February 21, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29467098/retention-engagement-and-adherence-to-pre-exposure-prophylaxis-for-men-who-have-sex-with-men-and-transgender-women-in-prep-brasil-48-week-results-of-a-demonstration-study
#7
Beatriz Grinsztejn, Brenda Hoagland, Ronaldo I Moreira, Esper G Kallas, Jose V Madruga, Silvia Goulart, Iuri C Leite, Lucilene Freitas, Luana M S Martins, Thiago S Torres, Ricardo Vasconcelos, Raquel B De Boni, Peter L Anderson, Albert Liu, Paula M Luz, Valdiléa G Veloso
BACKGROUND: PrEP Brasil was a demonstration study to assess feasibility of daily oral tenofovir diphosphate disoproxil fumarate plus emtricitabine provided at no cost to men who have sex with men (MSM) and transgender women at high risk for HIV within the Brazilian public health system. We report week 48 pre-exposure prophylaxis (PrEP) retention, engagement, and adherence, trends in sexual behaviour, and incidence of HIV and sexually transmitted infections in this study cohort. METHODS: PrEP Brasil was a 48 week, open-label, demonstration study that assessed PrEP delivery at three referral centres for HIV prevention and care in Rio de Janeiro, Brazil (Fundação Oswaldo Cruz), and São Paulo, Brazil (Universidade de São Paulo and Centro de Referência e Treinamento em DST e AIDS)...
February 16, 2018: Lancet HIV
https://www.readbyqxmd.com/read/29466505/molecular-detection-of-anaplasmataceae-agents-in-dasyprocta-azarae-in-northeastern-brazil
#8
Maria do Socorro Costa de Oliveira Braga, José Gomes Pereira, Simone de Jesus Fernandes, Ingrid Carolinne Lopes Marques, Renata Passos de Jesus, Gleycianny Santos Ferreira, Daniele Rosa Xavier, Jyan Lucas Benevenute, Rosangela Zacarias Machado, Marcos Rogério André
Recently, the importance of wild-living rodents for maintenance of pathogens of the family Anaplasmataceae in the environment was investigated. These mammals play a role as reservoirs for these pathogens and act as hosts for the immature stages of tick vectors. The aim of the present study was to investigate the prevalence of Ehrlichia sp. and Anaplasma sp. in 24 specimens of Azara's agouti (Dasyprocta azarae) that had been trapped in the Itapiracó Environmental Reserve, in São Luís, Maranhão, northeastern Brazil, using molecular methods...
February 19, 2018: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/29466502/endoparasites-in-domestic-animals-surrounding-an-atlantic-forest-remnant-in-s%C3%A3-o-paulo-state-brazil
#9
Anaiá da Paixão Sevá, Hilda Fátima de Jesus Pena, Alessandra Nava, Amanda Oliveira de Sousa, Luciane Holsback, Rodrigo Martins Soares
Morro do Diabo State Park (MDSP) is a significant remnant of the Atlantic Rain Forest in Brazil and is surrounded by rural properties. In that area, wild and domestic animals and humans are in close contact, which facilitates the two-way flow of infectious diseases among them. We assessed endoparasites in domestic livestock from all rural properties surrounding MDSP. There were sampled 197 cattle, 37 horses, 11 sheep, 25 swine, 21 dogs, one cat and 62 groups of chickens from 10 large private properties and 75 rural settlements...
February 19, 2018: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/29465282/typology-of-nightclubs-in-s%C3%A3-o-paulo-brazil-alcohol-and-illegal-drug-consumption-sexual-behavior-and-violence-in-the-venues
#10
Claudia M Carlini, Zila M Sanchez
BACKGROUND: Nightclubs are venues in which excessive alcohol use and illegal drug consumption occur in addition to other high-risk behaviors, such as violence and sexual risk behaviors. Environmental factors common in nightclubs and the personal characteristics of patrons might increase the risk of these events. To better understand the relationship between these factors, typologies were formulated that clustered nightclubs according to definite profiles to identify differences to be taken into consideration in preventive interventions...
February 21, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29464921/design-and-objectives-of-the-south-american-youth-child-cardiovascular-and-environmental-saycare-study
#11
Heráclito Barbosa Carvalho, Luis Alberto Moreno, Andrew Mello Silva, Gabriela Berg, Alejandro Estrada-Restrepo, Laura Inés González-Zapata, Pilar De Miguel-Etayo, Carlos Alberto Delgado, María Isabel Bove, Maria da Luz Rosario de Sousa, Francisco Leonardo Torres-Leal, Claudia L M Forjaz, Augusto César Ferreira De Moraes
OBJECTIVE: The purpose of this paper is to introduce the overarching study design of the South American Youth/Child Cardiovascular and Environmental (SAYCARE) study, which is an observational multicenter feasibility study held in seven South American cities: Buenos Aires (Argentina), Lima (Peru), Medellin (Colombia), Montevideo (Uruguay), Santiago (Chile), and São Paulo and Teresina (Brazil). Children and adolescents (3-17 years of age) were studied. METHODS: The data management systems, quality assurance monitoring activities, standardized operating procedure manuals, and training and study management are addressed in this paper...
March 2018: Obesity
https://www.readbyqxmd.com/read/29464920/development-of-a-food-frequency-questionnaire-for-assessing-dietary-intake-in-children-and-adolescents-in-south-america
#12
Luisa Saravia, Laura I González-Zapata, Tara Rendo-Urteaga, Jamile Ramos, Tatiana Sadalla Collese, Isabel Bove, Carlos Delgado, Florencia Tello, Iris Iglesia, Ederson Dassler Gonçalves Sousa, Augusto César Ferreira De Moraes, Heráclito Barbosa Carvalho, Luis A Moreno
OBJECTIVE: This study aimed to describe the development of a food frequency questionnaire (FFQ) to assess dietary intake in South American children and adolescents. METHODS: A total of 345 children (aged 3-10 years) and 357 adolescents (aged 11-17 years) were included for analysis. The FFQ was designed to be self-administered and to assess dietary intake over the past 3 months. It was developed in Spanish and translated into Portuguese. Multiple approaches were considered to compile the food list, and 11 food groups were included...
March 2018: Obesity
https://www.readbyqxmd.com/read/29462598/using-adult-aedes-aegypti-females-to-predict-areas-at-risk-for-dengue-transmission-a-spatial-case-control-study
#13
Maisa Carla Pereira Parra, Eliane Aparecida Fávaro, Margareth Regina Dibo, Adriano Mondini, Álvaro Eduardo Eiras, Erna Geessien Kroon, Mauro Martins Teixeira, Mauricio Lacerda Nogueira, Francisco Chiaravalloti-Neto
INTRODUCTION: Traditional indices for measuring dengue fever risk in a given area are based on the immature forms of the vector (larvae and pupae surveys). However, this is inefficient because only adult female mosquitoes actually transmit the virus. Based on these assumptions, our objective was to evaluate the association between an entomological index obtained from adult mosquito traps and the occurrence of dengue in a hyperendemic area. Additionally, we compared its cost to that of the Breteau Index (BI)...
February 17, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29459333/contamination-status-by-persistent-organic-pollutants-of-the-atlantic-spotted-dolphin-stenella-frontalis-at-the-metapopulation-level
#14
Paula Méndez-Fernandez, Satie Taniguchi, Marcos C O Santos, Irma Cascão, Sophie Quérouil, Vidal Martín, Marisa Tejedor, Manuel Carrillo, Carolina Rinaldi, Renato Rinaldi, Rosalinda C Montone
The Atlantic spotted dolphin (Stenella frontalis) is an endemic species of the tropical-temperate Atlantic Ocean with widespread distribution. Although this species has been the subject of a large number of studies throughout its range, it remains in the "data deficient" category of the International Union for Conservation of Nature (IUCN). Chemical pollution by persistent organic pollutants (POPs) has been listed as one of the major threats to this species, however, there is no information on a wide scale...
February 16, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29458448/rubella-antibodies-in-cord-blood-sera-in-portugal-association-with-maternal-age-and-vaccination-status
#15
J Frade, C Nunes, J R Mesquita, M São José Nascimento, G Gonçalves
This study evaluated the impact of maternal vaccination against rubella on the levels of specific rubella IgG (rIgG) in 198 newborn cord sera samples. Detailed maternal vaccination data were available. Specific rIgG was measured using a commercial enzyme immunoassay. Most mothers (78.8%) had been vaccinated against rubella at least once in their lives. In 15 (7.6%) cord sera samples, the concentration of specific rIgG was below 11 IU/ml, which was classified as seronegative. Statistical analysis using multiple logistic regression (n = 198) showed that newborns of mothers born between 1986 and 1995, and those born to unvaccinated mothers, were more likely to be seronegative (odds ratio (ORs) 5...
February 20, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29458266/acrylic-acid-grafted-tamarind-kernel-polysaccharide-based-hydrogel-for-bone-tissue-engineering-in-absence-of-any-osteoinducing-factors
#16
Satish Kumar, Rakesh Kumar Majhi, Sridhar Sanyasi, Chandan Goswami, Luna Goswami
With increased life expectancy, disorders in life style and other clinical conditions, the changes in the connective tissues such as in bone impose a diverse biomedical problems. Such problems are expensive, more serious in old ages and are fatal in certain pathophysiological settings which demands functional and/or artificial bones prepared at low cost. Cells having osteogenic properties and/or belong to osteogenic lineages are extremely specific for their surface requirements. Therefore, suitable surfaces are the critical bottle neck for successful bone tissue engineering...
February 20, 2018: Connective Tissue Research
https://www.readbyqxmd.com/read/29457918/quality-of-life-among-patients-during-subacute-phase-following-stroke-during-hospitalisation-period-in-shanghai
#17
Jiang Jingwen, Jin Han, Zhang Yu, Huang Xiaojun, Zhuang Junpeng, Shen Fanxia, Liu Jianrong
OBJECTIVE: This study aimed to investigate the factors influencing the quality of life of in-hospital subacute stroke patients. METHODS: The patients of subacute stroke (within four weeks) in our institution between 2015 and 2016 were recruited. Patients' characteristics and QOL were obtained from medical charts and stroke-specific quality of life scale (SS-QOL). Associations of each domain in SS-QOL with socio-demographic, clinical factors and patient satisfaction were investigated using the linear regression models...
February 19, 2018: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/29454927/syndemics-among-individuals-enrolled-in-the-prep-brasil-study
#18
Raquel B De Boni, Iona K Machado, Mauricio T L De Vasconcellos, Brenda Hoagland, Esper G Kallas, José Valdez Madruga, Nilo M Fernandes, Natalia B Cerqueira, Ronaldo I Moreira, Silvia P Goulart, Valdilea G Veloso, Beatriz Grinsztejn, Paula M Luz
BACKGROUND: Concurrent psychosocial problems may synergistically increase the risk of HIV infection (syndemics), representing a challenge for prevention. We aimed to evaluate the prevalence and associated factors of syndemics among men who have sex with men (MSM) and transgender women (TGW) enrolled in the Brazilian pre-exposure prophylaxis demonstration study (PrEP Brasil Study). METHODS: Secondary cross-sectional analysis of the PrEP Brasil Study was performed...
February 10, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29451915/synchronic-historical-patterns-of-species-diversification-in-seasonal-aplocheiloid-killifishes-of-the-semi-arid-brazilian-caatinga
#19
Wilson J E M Costa, Pedro F Amorim, José Leonardo O Mattos
The Caatinga is the largest nucleus of seasonally dry tropical forests in South America, but little is known about the evolutionary history and biogeography of endemic organisms. Evolutionary diversification and distribution of terrestrial vertebrates endemic to the Caatinga have been explained by palaeogeographical Neogene episodes, mostly related to changes in the course of the São Francisco River, the largest river in the region. Our objective is to estimate the timing of divergence of two endemic groups of short-lived seasonal killifishes inhabiting all ecoregions of the Caatinga, testing the occurrence of synchronic events of spatial diversification in light of available data on regional palaeogeography...
2018: PloS One
https://www.readbyqxmd.com/read/29451659/environmental-factors-can-influence-dengue-reported-cases
#20
Marco Antonio F Carneiro, Beatriz da C A Alves, Flávia de Sousa Gehrke, José Nuno Domingues, Nelson Sá, Susana Paixão, João Figueiredo, Ana Ferreira, Cleonice Almeida, Amaury Machi, Eriane Savóia, Vânia Nascimento, Fernando Fonseca
INTRODUCTION: Global climate changes directly affect the natural environment and contribute to an increase in the transmission of diseases by vectors. Among these diseases, dengue is at the top of the list. The aim of our study was to understand the consequences of temporal variability of air temperature in the occurrence of dengue in an area comprising seven municipalities of the Greater São Paulo. METHOD: Characterization of a temporal trend of the disease in the region between 2010 and 2013 was performed through analysis of the notified number of dengue cases over this period...
November 2017: Revista da Associação Médica Brasileira
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