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https://www.readbyqxmd.com/read/28530118/readmission-to-intensive-care-unit-incidence-risk-factors-resource-use-and-outcomes-a-retrospective-cohort-study
#1
Carolina R Ponzoni, Thiago D Corrêa, Roberto R Filho, Ary Serpa Neto, Murillo Sc Assunção, Andreia Pardini, Guilherme Pp Schettino
RATIONALE: Readmission to intensive care unit (ICU) is associated with poor clinical outcomes, increased length of ICU and hospital stay and higher costs. Nevertheless, knowledge on epidemiology of ICU readmissions, risk factors and attributable outcomes are restricted to developed countries. OBJECTIVES: Determine the effect of ICU readmissions on in-hospital mortality, incidence of ICU readmissions, identify predictors of ICU readmissions and hospital mortality and compare resource use and outcomes between readmitted and nonreadmitted patients in a developing country...
May 21, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28529574/knockdown-of-stmn1-enhances-osteosarcoma-cell-chemosensitivity-through-inhibition-of-autophagy
#2
Zili Wang, Rongzhen He, Hansong Xia, Yu Wei, Song Wu
Chemoresistance is a major cause for the poor prognosis of osteosarcoma (OS) patients. However, our understanding of mechanisms underlying chemoresistance in OS are limited. The present study aimed to investigate the effect of stathmin 1 (STMN1) on paclitaxel-induced chemoresistance, as well as the underlying mechanism. Western blot analysis data revealed that the expression level of STMN1 was dramatically increased in OS cell lines (HOS, Saos-2, U-2OS and MG-63), when compared to normal osteoblast hFOB1.19 cells...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28527729/the-hospitalization-profiles-of-patients-with-or-without-diabetes-treated-for-nontraumatic-lower-extremity-amputation-in-ribeir%C3%A3-o-preto-s%C3%A3-o-paulo-state-brazil-2001-2008
#3
Flávia F L Rodrigues, Domingos Alves, Carla R S Teixeira, Clarissa C A Arrelias, Maria T C G Torquato, Manoel A Santos, Maria Lucia Zanetti
The aim of this retrospective study was to assess the hospitalizations of patients with or without diabetes mellitus (DM) who underwent nontraumatic lower extremity amputation (NLEA) with regard to demographic and hospitalization-related variables. It is a high proportion of hospital beds in developing countries, for patients with diabetes mellitus with lower extremity complications. Nontraumatic amputations of lower extremities rates is an important indicator to assess the effectiveness of efforts to reduce chronic complications related to diabetic foot...
June 2017: Journal of Vascular Nursing: Official Publication of the Society for Peripheral Vascular Nursing
https://www.readbyqxmd.com/read/28526348/chitosan-co-hyaluronic-acid-porous-cryogels-and-their-application-in-tissue-engineering
#4
Tuğçe Kutlusoy, Burcu Oktay, Nilhan Kayaman Apohan, Mediha Süleymanoğlu, Serap Erdem Kuruca
In this work, the usability of chitosan-co-hyaluronic acid cryogels as a tissue-engineering scaffold was investigated. Chitosan-co-hyaluronic acid cryogels were synthesized at subzero temperature. Cryogels which were composed of various compositions of chitosan and hyaluronic acid (0, 10, 20, 30 and 50wt % hyaluronic acid) was prepared. Morphological studies showed that the macroporous cryogels have have been developed with 90-95% porosity. Particularly, the mechanical and biomaterial property of pure chitosan was improved by making copolymer with hyaluronic acid in different concentration...
May 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28523581/human-adenovirus-in-tissues-of-freshwater-snails-living-in-contaminated-waters
#5
J S Gularte, R Staggemeier, M Demoliner, T M S Heck, F H Heldt, R G F Ritzel, C Rigotto, A Henzel, F R Spilki
Human adenovirus (HAdV) is resistant to environment and can be used as a marker to detect fecal contamination. Considering the importance of freshwater snails in the aquatic environment, their use as concentrators for HAdV is a complementary tool for viral analysis of water. The goal of the study was to detect HAdV in snails and surface water collected from wetlands of the Sinos River (Rio Grande do Sul, Brazil) basin and to compare rates and viral loads found in both samples. HAdV was detected through real-time PCR...
June 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28523130/the-development-of-uniportal-video-assisted-thoracoscopic-surgery-in-s%C3%A3-o-paulo-from-diagnosis-to-lobectomy
#6
Alexandre de Oliveira, Thais Amarante P P Couto
BACKGROUND: The use of uniportal video-assisted thoracoscopic surgery (VATS) has been increasing worldwide. Our main goal was to describe the evolution of uniportal surgery in the biggest private hospital in Latin America that is located in São Paulo, Brazil. METHODS: This descriptive and retrospective study included patients who underwent uniportal VATS in the thoracic surgical department of Beneficencia Portuguesa Hospital, after being referred to our team to undergo the aforementioned procedure within the period from February 2012 to March 2016...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28523034/effects-of-sirna-mediated-hif-1%C3%AE-gene-silencing-on-angiogenesis-in-osteosarcoma
#7
Xu-Dong Zhang, Qiang Wu, Shu-Hua Yang
OBJECTIVE: To explore angiogenesis in osteosarcoma under the condition of hypoxia-inducible factor (HIF)-1α gene silenced by small interference RNA (siRNA). METHODS: The SaOS-2 osteosarcoma cells, transfected with the recombinant plasmid pSilencer2.1-HIF-1α or pSilencer2.1-SCR, were classified as HIF-1α/siRNA group or SCR/siRNA group, respectively. In which, vascular endothelial growth factor (VEGF) immunohistochemistry were performed. HIF-1α and VEGF protein contents were detected by western blot...
March 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28510642/ageism-in-health-care-a-systematic-review-of-operational-definitions-and-inductive-conceptualizations
#8
José Manuel Sousa São José, Carla Alexandra Filipe Amado, Stefania Ilinca, Sandra Catherine Buttigieg, Annika Taghizadeh Larsson
Purpose: International and national bodies have identified tackling ageism in health care as an urgent goal. However, health professionals, researchers, and policy makers recognize that it is not easy to identity and fight ageism in practice, as the identification of multiple manifestations of ageism is dependent on the way it is defined and operationalized. This article reports on a systematic review of the operational definitions and inductive conceptualizations of ageism in the context of health care...
May 16, 2017: Gerontologist
https://www.readbyqxmd.com/read/28510256/interregional-cytogenetic-comparisons-in-halichoeres-and-thalassoma-wrasses-labridae-of-coastal-and-insular-regions-of-the-southwestern-atlantic
#9
K D J Amorim, M B Cioffi, L A C Bertollo, R X Soares, L L Calado, A T Borges, G W W F Costa, W F Molina
The distribution patterns of marine biodiversity are complex, resulting from vicariant events and species dispersion, as well as local ecological and adaptive conditions. Furthermore, the wide geographic distribution of some species may be hindered by biogeographical barriers that can interfere in the gene flow. Cytogenetic analyses in marine fishes, especially those involving populations in small remote insular environments, remain scarce. In the Western Atlantic, species of wrasses from the genera Halichoeres and Thalassoma occur in biogeographic arrangements that make it possible to analyze cytogenetic patterns between coastal and widely separated island populations...
May 10, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28508697/collagen-concentration-on-the-facial-skin-of-postmenopausal-women-after-topical-treatment-with-estradiol-and-genistein-a-randomized-double-blind-controlled-trial
#10
Lidia Aragão Silva, Adriana Aparecida Ferraz Carbonel, Andréa Regina Barbosa de Moraes, Ricardo S Simões, Gisela Rodrigues da Silva Sasso, Lívia Goes, Winnie Nunes, Manuel Jesus Simões, Marisa Teresinha Patriarca
OBJECTIVE: The objective of this study is to compare the effects of topical estrogen and genistein (a soy isoflavone) on the facial skin collagen of postmenopausal women not undergoing systemic hormonal therapy. METHODS: This is a prospective, double blind, randomized, controlled clinical trial. Volunteer women (N = 30) 45-55 year old from the Endocrine Gynecology sector of the Gynecology Department of the Federal University of São Paulo (UNIFESP). The Ethical Committee of the Federal University of São Paulo approved the study (report no...
May 16, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28508573/regional-differences-in-the-management-and-outcome-of-kidney-transplantation-in-patients-with-human-immunodeficiency-virus-infection-a-3-year-retrospective-cohort-study
#11
Marina P Cristelli, Federico Cofán, Helio Tedesco-Silva, Joan Carles Trullàs, Daniel Wagner C L Santos, Cristian Manzardo, Fernando Agüero, Asunción Moreno, Federico Oppenheimer, Fritz Diekmann, Jose O Medina-Pestana, Jose Maria Miro
BACKGROUND: In the developed world, kidney transplantation (KT) in patients with human immunodeficiency virus (HIV) infection is well established. Developing countries concentrate 90% of the people living with HIV, but their experience is underreported. Regional differences may affect outcomes. OBJECTIVES: We compared the 3-year outcomes of patients with HIV infection receiving a KT in two different countries, in terms of incomes and development. METHODS: This was an observational, retrospective, double-center study, including all HIV-infected patients >18 years old undergoing KT...
May 16, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28508165/frequency-of-toxoplasma-gondii-in-the-retina-in-eye-banks-in-brazil
#12
Deise F Costa, Heloisa Nascimento, Aline Sutili, Fernando A J Nobrega, Flavio Fowler, Mario Junqueira Nobrega, Cristina Garrido, Janaina de Oliveira Dias, Consuelo B D Adán, Luiz Vicente Rizzo, Claudio Silveira, Rubens Belfort, Alessandra G Commodaro
Ocular toxoplasmosis is the main cause of posterior uveitis worldwide frequently leading to vision loss. In Brazil, the seroprevalence of Toxoplasma gondii infection ranges from 50 to 80% depending of the region studied. The frequency of toxoplasmic retinal scar may reach 18% of the adults in the South of Brazil. Our goal was to determine the frequency of T. gondii DNA in retinas from eye banks from different regions in Brazil. A total of 162 eyes were obtained from eye banks in Manaus (n = 60), Sao Paulo (n = 60), Chapeco (n = 26), and Joinville (n = 16)...
May 15, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28507748/comparison-of-the-pull-and-introducer-percutaneous-endoscopic-gastrostomy-techniques-in-patients-with-head-and-neck-cancer
#13
Felipe A Retes, Fabio S Kawaguti, Marcelo S de Lima, Bruno da Costa Martins, Ricardo S Uemura, Gustavo A de Paulo, Caterina Mp Pennacchi, Carla Gusmon, Adriana Vs Ribeiro, Elisa R Baba, Sebastian N Geiger, Mauricio P Sorbello, Marco A Kulcsar, Ulysses Ribeiro, Fauze Maluf-Filho
BACKGROUND AND STUDY AIMS: Percutaneous endoscopic gastrostomy (PEG) in head and neck cancer (HNC) patients is associated with higher complication and mortality rates when compared to a general patient population. The pull technique is still the preferred technique worldwide but it has some limitations. The aim of this study is to compare the pull and introducer PEG techniques in patients with HNC. PATIENTS AND METHODS: This study is based on a retrospective analysis of a prospectively collected database of 309 patients with HNC who underwent PEG in the Cancer Institute of São Paulo...
April 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28506936/assessment-of-long-term-mortality-in-patients-with-complex-coronary-artery-disease-undergoing-percutaneous-intervention-comparison-of-multiple-anatomical-and-clinical-prognostic-risk-scores
#14
Bruno L Janella, Carlos M Campos, Adriano Caixeta, Breno O Almeida, Fabio Sandoli Brito, Alexandre Abizaid, Marco A Perin
AIMS: Three-vessel and left main coronary artery disease (CAD) have important prognostic implications. Consequently, numerous risk scores have been developed to stratify patients with complex CAD. The aim of the present study is to compare the predictive performance of six risk scores for occurrence of 4-year all-cause mortality. METHODS AND RESULTS: From March 2008 to December 2012, 348 consecutive patients with complex CAD undergoing percutaneous coronary intervention in a tertiary center in São Paulo, Brazil were analyzed...
May 16, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28506709/behavior-of-macrophage-and-osteoblast-cell-lines-in-contact-with-the-%C3%AE-tcp-biomaterial-beta-tricalcium-phosphate
#15
B Arbez, H Libouban
Beta-tricalcium phosphate (β-TCP) is a synthetic ceramic used for filling bone defects. It is a good alternative to autologous grafts since it is biocompatible, resorbable and osteoconductive. Previous in vivo studies have shown that macrophages are one of the first cells coming in contact with the biomaterial followed by osteoclasts and osteoblasts that will elaborate new bone packets. Studies have focused on osteoclast morphology and very few of them have investigated the role of macrophages. The aims of this study were to characterize (i) the biomaterial surface; (ii) the in vitro behavior of macrophages (J774...
May 12, 2017: Morphologie: Bulletin de L'Association des Anatomistes
https://www.readbyqxmd.com/read/28506666/prevalence-and-factors-associated-with-body-mass-index-in-children-aged-9-11-years
#16
Gerson Luis de Moraes Ferrari, Victor Matsudo, Peter T Katzmarzyk, Mauro Fisberg
OBJECTIVE: This study aimed to identify the prevalence and factors associated with body mass index (BMI) in children aged 9-11 years. METHODS: The study is part of the International Study of Childhood Obesity Lifestyle and the Environment (ISCOLE). Body composition was determined using the bipolar bioimpedance technique. The mean BMI value was categorized as recommended by the World Health Organization. For seven consecutive days, participants used an accelerometer to objectively monitor sedentary behavior (SB) and moderate to vigorous physical activity...
May 12, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28506539/description-of-a-new-soft-tick-species-acari-argasidae-ornithodoros-associated-with-stream-breeding-frogs-anura-cycloramphidae-cycloramphus-in-brazil
#17
Sebastián Muñoz-Leal, Luís Felipe Toledo, José M Venzal, Arlei Marcili, Thiago F Martins, Igor C L Acosta, Adriano Pinter, Marcelo B Labruna
In this study, we present a morphological description of immature and adult specimens of Ornithodoros saraivai n. sp., a tick associated with the frog Cycloramphus boraceiensis (Cycloramphidae) at São Sebastião island, located in the São Paulo state seaboard, Brazil. While larvae of O. saraivai are ecologically related to Ornithodoros faccinii, another soft tick associated with cycloramphids, the combination of 7 sternal pairs, 16 dorsal pairs, a pyriform dorsal plate and a partially toothed hypostome constitute unique characters of the O...
May 10, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28504433/influence-of-shading-and-pedestrian-traffic-on-the-preference-of-aedes-stegomyia-aegypti-diptera-culicidae-for-oviposition-microenvironments
#18
G P Prado, J S Maciel, G R Leite, M A A Souza
Aedes aegypti mosquitoes are highly adaptable to abiotic stimuli. To evaluate the influence of shading and pedestrian traffic on the preference of Ae. aegypti for oviposition microenvironments, 20 sites were sampled weekly using ovitraps within the perimeter of Universidade Federal do Espírito Santo, located in São Mateus, Espírito Santo, Brazil. A spatial and statistical analysis was performed in order to assess the relationship between shading time, pedestrian traffic, and the presence of biological forms of Ae...
June 2017: Journal of Vector Ecology: Journal of the Society for Vector Ecology
https://www.readbyqxmd.com/read/28504095/characterization-of-porcine-trueperella-pyogenes-by-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-maldi-tof-ms-molecular-typing-and-antimicrobial-susceptibility-profiling-in-sao-paulo-state
#19
Luisa Z Moreno, Carlos E C Matajira, Barbara L P da Costa, Thais S P Ferreira, Givago F R Silva, Mauricio C Dutra, Vasco T M Gomes, Ana Paula S Silva, Ana Paula G Christ, Maria Inês Z Sato, Andrea M Moreno
Trueperella pyogenes can be found as a commensal or pathogenic bacterium among animals causing a variety of pyogenic infections in several species. The agent appears to act primarily as an opportunistic pathogen but may disseminate and produce metastatic abscesses accompanied or not by mastitis, metritis or pneumonia. In this study, 30 porcine T. pyogenes strains were identified by MALDI-TOF MS and 16S rRNA sequencing and further evaluated in relation to their resistance and genetic profiles through broth microdilution and single enzyme AFLP...
April 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28503805/development-of-a-siyalon-glaze-for-improved-osteoconductivity-of-implantable-medical-devices
#20
Ryan M Bock, Elia Marin, Alfredo Rondinella, Francesco Boschetto, Tetsuya Adachi, Bryan J McEntire, B Sonny Bal, Giuseppe Pezzotti
The application of bioactive coatings onto orthopaedic appliances is commonly performed to compensate for the otherwise bioinert nature of medical devices and to improve their osseointegration. Calcium phosphates, hydroxyapatite (HAp), and bioglasses are commercially available for this purpose. Until recently, few other inorganic compounds have been identified with similar biofunctionality. However, silicon nitride (Si3 N4 ) has emerged as a new orthopaedic material whose unique surface chemistry also enhances osteoconductivity...
May 15, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
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