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https://www.readbyqxmd.com/read/28430679/cervicovaginal-levels-of-human-%C3%AE-defensin-1-2-3-and-4-of-reproductive-aged-women-with-chlamydia-trachomatis-infection
#1
Nathália Mayumi Noda-Nicolau, Larissa Brito Bastos, Aline Nascimento Bolpetti, Gabriel Vitor Silva Pinto, Larissa Doddi Marcolino, Camila Marconi, Carolina Sanitá Tafner Ferreira, Jossimara Polettini, Eliane Passarelli Vieira, Márcia Guimarães da Silva
OBJECTIVE: This study included women attending primary health care units in Botucatu, São Paulo, Brazil, to assess the cervicovaginal levels of human β-defensin (hBD) 1, 2, 3, and 4 during Chlamydia trachomatis infection. PATIENTS AND METHODS: Cervicovaginal samples were collected for Pap testing and assessing the presence of infection by C. trachomatis, human papillomavirus, Neisseria gonorrhoeae, and Trichomonas vaginalis. Vaginal smears were taken to evaluate local microbiota...
April 21, 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28427438/canine-%C3%AE-defensin-1-cbd1-gene-as-a-possible-marker-for-leishmania-infantum-infection-in-dogs
#2
Lidiane Gomes da Silva, César Raimundo Lima Costa-Júnior, Carlos Alberto Santiago Figueiredo-Júnior, Tereza Cristina Leal-Balbino, Sergio Crovella, Domenico Otranto, Valdir de Queiroz Balbino, Filipe Dantas-Torres
BACKGROUND: Canine leishmaniasis caused by Leishmania infantum is a parasitic disease of great veterinary significance. Some dogs infected by L. infantum may mount a strong cellular immune response and clear the infection, while others may respond with exaggerated antibody production against the parasite and develop an overt disease, which may be fatal, if left untreated. The initial factors triggering the polarization of the immune response towards a predominantly T-helper 1 or T-helper 2 cytokines, as well as the markers of resistance and susceptibility to L...
April 20, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28427322/dental-pulp-pluripotent-like-stem-cells-dppsc-a-new-stem-cell-population-with-chromosomal-stability-and-osteogenic-capacity-for-biomaterials-evaluation
#3
Raquel Núñez-Toldrà, Ester Martínez-Sarrà, Carlos Gil-Recio, Miguel Ángel Carrasco, Ashraf Al Madhoun, Sheyla Montori, Maher Atari
BACKGROUND: Biomaterials are widely used to regenerate or substitute bone tissue. In order to evaluate their potential use for clinical applications, these need to be tested and evaluated in vitro with cell culture models. Frequently, immortalized osteoblastic cell lines are used in these studies. However, their uncontrolled proliferation rate, phenotypic changes or aberrations in mitotic processes limits their use in long-term investigations. Recently, we described a new pluripotent-like subpopulation of dental pulp stem cells derived from the third molars (DPPSC) that shows genetic stability and shares some pluripotent characteristics with embryonic stem cells...
April 21, 2017: BMC Cell Biology
https://www.readbyqxmd.com/read/28424961/tillandsia-usneoides-a-successful-alternative-for-biomonitoring-changes-in-air-quality-due-to-a-new-highway-in-s%C3%A3-o-paulo-brazil
#4
EDITORIAL
Poliana Cardoso-Gustavson, Francine Faia Fernandes, Edenise Segala Alves, Mariana Pereira Victorio, Barbara Baesso Moura, Marisa Domingos, Caroline Albuquerque Rodrigues, Andreza Portella Ribeiro, Catarina Carvalho Nievola, Ana Maria G Figueiredo
No abstract text is available yet for this article.
April 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28423140/arboviruses-emerging-in-brazil-challenges-for-clinic-and-implications-for-public-health
#5
Maria Rita Donalisio, André Ricardo Ribas Freitas, Andrea Paula Bruno Von Zuben
Arboviruses have been emerging in different parts of the world due to genetic changes in the virus, alteration of the host and vector population dynamics, or because of anthropogenic environmental factors. These viruses' capacity for adaptation is notable, as well as the likelihood of their emergence and establishment in new geographic areas. In Brazilian epidemiologic scenario, the most common arboviruses are DENV, CHIKV, and ZIKV, although others may spread in the country. Little is yet known of the impact of viral co-circulation, which would theoretically result in more intense viremia or other immunological alterations that could trigger autoimmune diseases, such as Guillain-Barré syndrome...
April 10, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28423077/early-devonian-late-emsian-shark-fin-remains-chondrichthyes-from-the-paran%C3%A3-basin-southern-brazil
#6
Martha Richter, Elvio P Bosetti, Rodrigo S Horodyski
We report on the pioneering discovery of Devonian fish remains in the Paraná Basin, which represents the southernmost record of fishes from that period in mainland South America. The material comes from an outcrop at the lower portion of the São Domingos Formation, within Sequence C of the Paraná-Apucarana sub-basin in Tibagi, State of Paraná. Marine invertebrates are abundant in the same strata. The dark colored fish remains were collected in situ and represent natural moulds of partially articulated shark fin rays (radials)...
January 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28423068/suicide-and-meteorological-factors-in-s%C3%A3-o-paulo-brazil-1996-2011-a-time-series-analysis
#7
Daniel H Bando, Chei T Teng, Fernando M Volpe, Eduardo de Masi, Luiz A Pereira, Alfésio L Braga
Objective: Considering the scarcity of reports from intertropical latitudes and the Southern Hemisphere, we aimed to examine the association between meteorological factors and suicide in São Paulo. Method: Weekly suicide records stratified by sex were gathered. Weekly averages for minimum, mean, and maximum temperature (°C), insolation (hours), irradiation (MJ/m2), relative humidity (%), atmospheric pressure (mmHg), and rainfall (mm) were computed. The time structures of explanatory variables were modeled by polynomial distributed lag applied to the generalized additive model...
April 13, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28422548/epidemiological-profile-and-treatment-outcomes-in-young-adults-19-29-years-of-age-treated-for-cancer-in-a-tertiary-hospital-in-s%C3%A3-o-paulo-brazil
#8
Victor Hugo Fonseca de Jesus, Taynan Nunes Ribeiro, Ludmilla T Domingos Chinen, Vanessa Alves, Maria Paula Curado, Marcello Ferretti Fanelli
BACKGROUND: Worldwide, the incidence of cancer in young adults (20-39 years) is increasing, and represents an important cause of mortality in this age group. A retrospective study was undertaken to provide information that may lead to improved treatment outcomes. METHODS: Epidemiological, clinicopathological, treatment, and survival information were retrieved from the electronic database registry of a tertiary referral hospital in São Paulo, Brazil for patients 19-29 years of age diagnosed with cancer between January 2007 and December 2012...
April 19, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28421269/thermal-balance-of-nellore-cattle
#9
Cíntia Carol de Melo Costa, Alex Sandro Campos Maia, Sheila Tavares Nascimento, Carolina Cardoso Nagib Nascimento, Marcos Chiquitelli Neto, Vinícius de França Carvalho Fonsêca
This work aimed at characterizing the thermal balance of Nellore cattle from the system of indirect calorimetry using a facial mask. The study was conducted at the Animal Biometeorology Laboratory of the São Paulo State University, Jaboticabal, Brazil. Five male Nellore weighing 750 ± 62 kg, at similar ages and body conditions were distributed in four 5 × 5 Latin squares (5 days of records and five schedules) during 20 days. Physiological and environmental measurements were obtained from the indirect calorimetry system using a facial mask...
April 18, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28419547/perinatal-dna-methylation-at-cdkn2a-is-associated-with-offspring-bone-mass-findings-from-the-southampton-women-s-survey
#10
Elizabeth M Curtis, Robert Murray, Philip Titcombe, Eloïse Cook, Rebecca Clarke-Harris, Paula Costello, Emma Garratt, Joanna D Holbrook, Sheila Barton, Hazel Inskip, Keith M Godfrey, Christopher G Bell, Cyrus Cooper, Karen A Lillycrop, Nicholas C Harvey
Poor intrauterine and childhood growth has been linked with the risk of osteoporosis in later life, a relationship which may in part be mediated through altered epigenetic regulation of genes. We previously identified a region within the promoter of the long non-coding RNA ANRIL encoded by the CDKN2A locus, at which differential DNA methylation at birth showed correlations with offspring adiposity. Given the common lineage of adipocytes and osteoblasts, we investigated the relationship between perinatal CDKN2A methylation and bone mass at ages 4 and 6 years...
April 17, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28419264/evaluating-the-impact-of-contracting-out-basic-health-care-services-in-the-state-of-s%C3%A3-o-paulo-brazil
#11
Jane Greve, Vera Schattan Ruas Pereira Coelho
As a means of dealing with shortcomings in the coverage, quality and efficiency of the public health care sector, several municipalities in the state of São Paulo, Brazil, have started to contract pre-certified non-profit or non-governmental organizations to take part in the delivery of health care services.This paper explores the impact of introducing these contracts in the primary health care sector. Using data on the 645 municipalities in the state of São Paulo and difference-in-differences methods, we estimate the effect of contracting out in the primary health care sector on various dimensions of mortality and health care use...
April 16, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28418833/willingness-to-pay-in-caregivers-of-patients-affected-by-schizophrenia
#12
Claudiane Salles Daltio, Cecilia Attux, Marcos Bosi Ferraz
BACKGROUND: Schizophrenia is a debilitating disorder that often requires the affected individual to receive care from a caregiver. Willingness to Pay (WTP) technique allows a valuation of the health state preferences by assessing the impact of the disease and translating it into monetary terms. AIMS OF THE STUDY: The objective was to determine the WTP of schizophrenic patients' caregivers on a hypothetical recovery scenario and correlate it to socio-demographic and clinical characteristics, Knowledge of Disease, Quality of life and Burden of Disease...
March 1, 2017: Journal of Mental Health Policy and Economics
https://www.readbyqxmd.com/read/28418232/high-pre-exposure-prophylaxis-uptake-and-early-adherence-among-men-who-have-sex-with-men-and-transgender-women-at-risk-for-hiv-infection-the-prep-brasil-demonstration-project
#13
Brenda Hoagland, Ronaldo I Moreira, Raquel B De Boni, Esper G Kallas, José Valdez Madruga, Ricardo Vasconcelos, Silvia Goulart, Thiago S Torres, Luana M S Marins, Peter L Anderson, Paula M Luz, Iuri da Costa Leite, Albert Y Liu, Valdilea G Veloso, Beatriz Grinsztejn
INTRODUCTION: The efficacy of pre-exposure prophylaxis (PrEP) in preventing sexual acquisition of human immunodeficiency virus (HIV) is well established. Little is known about the feasibility of PrEP implementation in middle-income settings with concentrated epidemics among men who have sex with men (MSM) and transgender women (TGW). METHODS: PrEP Brasil is a prospective, multicentre, open-label demonstration project assessing PrEP delivery in the context of the Brazilian Public Health System...
April 6, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28415457/a-novel-nano-hydroxyapatite-pmma-hybrid-scaffolds-adopted-by-conjugated-thermal-induced-phase-separation-tips-and-wet-chemical-approach-analysis-of-its-mechanical-and-biological-properties
#14
Radha G, Balakumar S, Balaji Venkatesan, Elangovan Vellaichamy
In this study, we report the preparation of nano-hydroxyapatite (nHAp) incorporated poly(methyl methacrylate) (PMMA) scaffolds by conjugated thermal induced phase separation (TIPS) and wet-chemical approach, which essentially facilitates the enhancement of both mechanical as well as biological properties of the scaffolds. The dissolution of PMMA was accomplished by acetone (Ace scaffold), ethanol-water (E-W scaffold) and isopropanol-water (I-W scaffold) mixtures as solvents. The existence of nHAp in PMMA matrix was investigated systematically...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28412600/dna-methylation-changes-at-trem2-intron-1-and-trem2-mrna-expression-in-patients-with-alzheimer-s-disease
#15
Yuki Ozaki, Yuta Yoshino, Kiyohiro Yamazaki, Tomoko Sao, Yoko Mori, Shinichiro Ochi, Taku Yoshida, Takaaki Mori, Jun-Ichi Iga, Shu-Ichi Ueno
OBJECTIVES: Recent genome-wide association studies revealed that Triggering receptor expressed on myeloid cells 2 (TREM2) was associated with Alzheimer's disease (AD) and other neurodegenerative diseases. We previously reported that TREM2 mRNA is highly expressed in leukocytes of AD patients compared to those in healthy controls. However, the mechanism of TREM2 expression change is still not known. In this study, we examined the involvement of the DNA methylation status of TREM2 in its high gene expression...
April 11, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28411890/time-to-rethink-transanal-endoscopic-microsurgery-for-rectal-cancer-after-neoadjuvant-chemoradiation-for-highly-selected-patients
#16
EDITORIAL
Rodrigo Oliva Perez, Guilherme Pagin São Julião, Bruna Borba Vailati
No abstract text is available yet for this article.
April 12, 2017: Cirugía Española
https://www.readbyqxmd.com/read/28411314/dental-enamel-as-biomarker-for-environmental-contaminants-in-relevant-industrialized-estuary-areas-in-s%C3%A3-o-paulo-brazil
#17
Vera Lucia Ferreira de Oliveira, Raquel Fernanda Gerlach, Lourdes Conceição Martins, Carolina de Souza Guerra, Paulo Frazão, Alfésio Luis Ferreira Braga, Luiz Alberto Amador Pereira
Heavy metal contamination is a long-standing and very well-known public health problem, and its exposure can cause damage to several organs of human body, especially on the central nervous system of young children and teenagers. The aim of this article is to evaluate lead, cadmium, and manganese contamination in 125 children from 6 to 13 years old living in contaminated areas during the period from 2006 to 2009 (São Vicente, Cubatão Downtown, Bertioga and Cubatão Pilões/Água Fria). This estuary area is the most important example of environmental degradation by chemicals from industrial sources...
April 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28408345/icariin-protects-against-glucocorticoid-induced-osteoporosis-increases-the-expression-of-the-bone-enhancer-dec1-and-modulates-the-pi3k-akt-gsk3%C3%AE-%C3%AE-catenin-integrated-signaling-pathway
#18
Hu Jinhua, Mao Zhao, He Shuangcheng, Zhan Yuanran, Ning Rui, Liu Wei, Yan Bingfang, Yang Jian
Osteoporosis is a serious public health concern worldwide. Herba epimedii has been used for centuries and even thousands of years to treat osteoporotic conditions. Icariin, a flavonol glycoside, is one of the major active ingredients. In this study, we have shown that icariin protected against glucocorticoid-induced osteoporotic changes in SaoS-2 cells and mice. We have also shown that dexamethasone (a glucocorticoid) suppressed and icariin induced DEC1, a structurally distinct helix-loop-helix protein. DEC1 overexpression promoted whereas DEC1 knockdown decreased osteogenic activity...
April 10, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28406757/rabies-virus-exposure-of-brazilian-free-ranging-wildlife-from-municipalities-without-clinical-cases-in-humans-or-in-terrestrial-wildlife
#19
João Marcelo Azevedo de Paula Antunes, Larissa de Castro Demoner, Tatiana Morosini de Andrade Cruvinel, Ana Paula Kataoka, Luzia Fátima Alves Martorelli, Gustavo Puglia Machado, Jane Megid
Rabies is a zoonosis that causes thousands of animal and human deaths worldwide. Serological studies provide information concerning rabies virus circulation among animals and humans. We evaluated the circulation of the rabies virus in wildlife in nine municipalities of São Paulo State, Brazil. We took blood samples from 27 terrestrial animals of nine different mammalian species in locations without cases of rabies in human and wild terrestrial mammals. Sera were tested with the use of the rapid fluorescent focus inhibition test (RFFIT) for the detection of rabies virus-neutralizing antibodies (RVNA)...
April 13, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28404508/model-based-analyses-reveal-insular-population-diversification-and-cryptic-frog-species-in-the-ischnocnema-parva-complex-in-the-atlantic-forest-of-brazil
#20
Marcelo Gehara, Adriane Barth, Eliana Faria de Oliveira, Marco Antonio Costa, Célio Fernando Baptista Haddad, Miguel Vences
The Atlantic Forest (AF) of Brazil has long been recognized as a biodiversity conservation hotspot. Despite decades of studies the species inventory of this biome continues to increase with the discovery of cryptic diversity and the description of new species. Different diversification mechanisms have been proposed to explain the diversity in the region, including models of forest dynamics, barriers to gene flow and dispersal. Also, sea level change is thought to have influenced coastal diversification and isolated populations on continental islands...
April 9, 2017: Molecular Phylogenetics and Evolution
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