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https://www.readbyqxmd.com/read/28331235/analysis-of-prognostic-factors-for-survival-after-surgery-for-gallbladder-cancer-based-on-a-bayesian-network
#1
Zhi-Qiang Cai, Peng Guo, Shu-Bin Si, Zhi-Min Geng, Chen Chen, Long-Long Cong
The factors underlying prognosis for gallbladder cancer (GBC) remain unclear. This study combines the Bayesian network (BN) with importance measures to identify the key factors that influence GBC patient survival time. A dataset of 366 patients who underwent surgical treatment for GBC was employed to establish and test a BN model using BayesiaLab software. A tree-augmented naïve Bayes method was also used to mine relationships between factors. Composite importance measures were applied to rank the influence of factors on survival time...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28331137/evaluation-of-surgical-procedures-for-t2-gallbladder-cancer-in-terms-of-recurrence-and-prognosis
#2
Ryuichi Kawahara, Takahisa Shirahama, Shyoichirou Arai, Daisuke Muroya, Yoriko Nomura, Shogo Fukutomi, Nobuhisa Shirahama, Katsuaki Takagi, Yuichi Goto, Masanori Akashi, Yuichirou Maruyama, Hisamune Sakai, Hiroto Ishikawa, Toru Hisaka, Masafumi Yasunaga, Hiroyuki Horiuchi, Koji Okuda, Yoshito Akagi, Hiroyuki Tanaka
T2 (tumor invades perimuscular connective tissue; no extension beyond serosa or into liver) gallbladder cancer has generally been treated by S4aS5 subsegmentectomy (S4aS5 HR). We investigated the therapeutic effect of full-thickness cholecystectomy (FC) and gallbladder bed resection (GBR), in terms of tumor location and resection margin (distance from the tumor). At our department we employ the following protocol to determine the extent of resection needed to achieve R0 status: (1) A tumor located in the gallbladder fundus (Gf) or body (Gb) and only on the free peritoneal side was classified as P-type, for which full-thickness cholecystectomy and regional lymph node dissection were performed...
March 22, 2017: Kurume Medical Journal
https://www.readbyqxmd.com/read/28329919/-chemotherapy-for-biliary-tract-cancer
#3
REVIEW
Sang Myung Woo
The term of biliary tract cancer (BTC) refers to all tumors that arise from the biliary tract or the biliary drainage system, including the intra- and extra-hepatic bile ducts as well as the gallbladder. BTCs are aggressive tumors with limited treatment options and poor overall survival. Currently, surgery remains to be the only potentially curative treatment, and most patients develop recurrence. For advanced tumors, only limited effective treatment modalities exist today. Gemcitabine plus cisplatin is considered as a standard option for advanced biliary cancer...
March 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28324023/long-chain-free-fatty-acid-receptor-gpr120-mediates-oil-induced-gip-secretion-through-cck-in-male-mice
#4
Akiko Sankoda, Norio Harada, Kanako Iwasaki, Shunsuke Yamane, Yuki Murata, Kimitaka Shibue, Yotsapon Thewjitcharoen, Kazuyo Suzuki, Takanari Harada, Yoshinori Kanemaru, Satoko Shimazu-Kuwahara, Akira Hirasawa, Nobuya Inagaki
Free fatty acid receptors GPR120 and GPR40 are involved in the secretion of gut hormones. GPR120 and GPR40 are expressed in enteroendocrine K-cells and their activation induces the secretion of the incretin glucose-dependent insulinotropic polypeptide (GIP). However, the role of these receptors in fat-induced GIP secretion in vivo and the associated mechanisms are unclear. In this study, we investigated corn oil-induced GIP secretion in GPR120-knockout (GPR120-/-) and GPR40-knockout (GPR40-/-) mice. Oil-induced GIP secretion was reduced by 50% and 80% in GPR120-/- and GPR40-/- mice compared to that in wild-type (WT) mice, respectively...
March 15, 2017: Endocrinology
https://www.readbyqxmd.com/read/28321707/the-mucocele-of-the-gallbladder
#5
Gennaro Clemente, Valeria Fico, Davide De Sio, Agostino Maria De Rose
The gallbladder polyps are a common finding during ultrasonography but only in rare cases they may be a cancer. When a polyp is greater than 1 cm, the cholecystectomy is usually performed. In these images, a polyp of 4 cm corresponding to a collection of mucus (mucocele) is reported. This unusual polyp of the gallbladder was caused by heterotopic intestinal mucosa.
March 20, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28317286/trend-analysis-and-survival-of-primary-gallbladder-cancer-in-the-united-states-a-1973-2009-population-based-study
#6
Rubayat Rahman, Eduardo J Simoes, Chester Schmaltz, Christian S Jackson, Jamal A Ibdah
Primary gallbladder cancer is an aggressive and uncommon cancer with poor outcomes. Our study examines epidemiology, trend, and survival of gallbladder cancer in the United States from 1973 to 2009. We utilized the Surveillance Epidemiology and End Results database (SEER). Frequency and rate analyses on demographics, stage, and survival were compared among non-Hispanic whites, Hispanics, African American, and Asian/Pacific Islanders. A total of 18,124 cases were reported in SEER from 1973 to 2009 comprising 1...
March 20, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28317208/current-status-of-interventional-endoscopic-ultrasound
#7
REVIEW
Shomei Ryozawa, Naotaka Fujita, Atsushi Irisawa, Yoshiki Hirooka, Tetsuya Mine
Endoscopic ultrasound (EUS) is being used increasingly in the management of pancreatic fluid collection, biliary and pancreatic duct drainage in cases of failed endoscopic retrograde cholangiopancreatography, drainage of the gallbladder, and other conditions. The role of interventional EUS is rapidly expanding and new interventions are continuously emerging. The development of devices could be a major breakthrough in the field of interventional EUS. New devices would enable the expansion of its role even further and prompt its widespread use in clinical practice...
March 20, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28317042/impact-of-scheduled-laparoscopic-cholecystectomy-in-patients-with-acute-cholecystitis-following-percutaneous-transhepatic-gallbladder-drainage
#8
Bo-Hyun Jung, Jeong-Ik Park
BACKGROUNDS/AIMS: Frequently encountered in practice, the first-line treatment for acute cholecystitis is early or urgent cholecystectomy, with laparoscopic cholecystectomy (LC) being the preferred method. Percutaneous transhepatic gallbladder drainage (PTGBD) is considered as a safe alternative therapeutic option for resolving acute cholecystitis in surgically high-risk patients. We evaluated the surgical outcomes of acute cholecystitis, focusing on the differences between emergent LC without PTGBD, and scheduled LC following PTGBD...
February 2017: Ann Hepatobiliary Pancreat Surg
https://www.readbyqxmd.com/read/28316322/predictive-factors-of-neoplastic-gallbladder-polyps-outcomes-of-278-patients
#9
Serdar Gökay Terzioğlu, Murat Özgür Kılıç, Ali Sapmaz, Ahmet Serdar Karaca
BACKGROUND/AIMS: Distinguishing between neoplastic and nonneoplastic gallbladder polyps (GBPs) in the preoperative workup is of great importance for appropriate treatment. The present study aimed to investigate the characteristics of GBPs and to determine potential predictive factors of neoplastic polyps. MATERIALS AND METHODS: The data of 278 patients who were confirmed to have GBPs through laparoscopic cholecystectomy were retrospectively analyzed. Polyps were classified as nonneoplastic and neoplastic GBPs, according to histopathological diagnoses...
March 17, 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28316140/descriptive-review-of-acute-cholecystitis-japan-taiwan-collaborative-epidemiological-study
#10
Masamichi Yokoe, Tadahiro Takada, Tsann-Long Hwang, Itaru Endo, Kohei Akazawa, Fumihiko Miura, Toshihiko Mayumi, Rintaro Mori, Miin-Fu Chen, Yi-Yin Jan, Chen-Guo Ker, Hsiu-Po Wang, Takao Itoi, Harumi Gomi, Seiki Kiriyama, Hiroki Yamaue, Masaru Miyazaki, Masakazu Yamamoto
BACKGROUND AND AIMS: Since the publication of the Tokyo Guidelines (TG13) for the management of acute cholecystitis (AC), multidirectional studies have been published. However epidemiological research about AC with big data was not projected. The aim of this study was to reveal the actual clinical conditions of AC. METHOD: The study was designed as an international multicenter retrospective study of AC in Japan and Taiwan from 2011 to 2013. The factors investigated comprised data related to demographic, history, physical examinations, laboratory and imaging findings...
March 18, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28315816/longest-gallbladder-a-case-report
#11
Rahul Yadav, Jeevan Kankaria
INTRODUCTION: A gallbladder mucocele is the distention of the gallbladder by an inappropriate accumulation of mucus. Decreased bile flow, decreased gallbladder motility, and altered absorption of water from the gallbladder lumen are predisposing factors to biliary sludge. However, it is more likely to be a small part of a complex disease process involving inflammation of the gallbladder wall and changes to the lining of the gallbladder changing the consistency of its secretions. We would like to present a case of mucocele gallbladder operated successfully by laparoscopic cholecystectomy...
February 28, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28315653/techniques-for-nonterminal-blood-sampling-in-black-tailed-prairie-dogs-cynomys-ludovicianus
#12
Valerie Head, David Eshar, Melissa R Nau
Black-tailed prairie dogs (Cynomys ludovicianus) are used as an animal model for research on gallbladder stones and several infectious diseases. A comprehensive, instructive resource regarding the appropriate techniques for venipuncture and collection of nonterminal blood samples in this species has not yet been published. Blood samples (1 mL or larger) were readily obtained from the jugular vein, femoral vein, or cranial vena cava, whereas peripheral sites, such as the cephalic vein, saphenous vein, and tarsal vein, mainly were useful for obtaining smaller volumes...
March 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28314823/body-size-indicators-and-risk-of-gallbladder-cancer-pooled-analysis-of-individual-level-data-from-19-prospective-cohort-studies
#13
Peter T Campbell, Christina C Newton, Cari M Kitahara, Alpa V Patel, Patricia Hartge, Jill Koshiol, Katherine A McGlynn, Hans-Olov Adami, Amy Berrington de González, Laura E Beane Freeman, Leslie Bernstein, Julie E Buring, Neal D Freedman, Yu-Tang Gao, Graham G Giles, Marc J Gunter, Mazda Jenab, Linda M Liao, Roger L Milne, Kim Robien, Dale P Sandler, Catherine Schairer, Howard D Sesso, Xiao-Ou Shu, Elisabete Weiderpass, Alicja Wolk, Yong-Bing Xiang, Anne Zeleniuch-Jacquotte, Wei Zheng, Susan M Gapstur
Background: There are few established risk factors for gallbladder cancer beyond gallstones. Recent studies suggest a higher risk with high body mass index (BMI), an indicator of general heaviness, but evidence from other body size measures is lacking.Methods: Associations of adult BMI, young adult BMI, height, adult weight gain, waist circumference (WC), waist-height ratio (WHtR), hip circumference (HC), and waist-hip ratio (WHR) with gallbladder cancer risk were evaluated. Individual-level data from 1,878,801 participants in 19 prospective cohort studies (14 studies had circumference measures) were harmonized and included in this analysis...
March 17, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28314252/clinical-target-volume-in-biliary-carcinoma-a-systematic-review-of-pathological-studies
#14
REVIEW
Ilaria Marinelli, Alessandra Guido, Lorenzo Fuccio, Andrea Farioli, Valeria Panni, Lucia Giaccherini, Alessandra Arcelli, Giorgio Ercolani, Giovanni Brandi, Silvia Cammelli, Andrea Galuppi, Gabriella Macchia, Rezarta Frakulli, Gian C Mattiucci, Francesco Cellini, Milly Buwenge, Matteo Renzulli, Francesco Deodato, Savino Cilla, Vincenzo Valentini, Vincenzo Tombolini, Rita Golfieri, Alessio G Morganti
BACKGROUND/AIM: Radiotherapy is a treatment option for both adjuvant and neo-adjuvant settings for biliary tract cancer. Guidelines on the delineation of the target volume of lymph nodes are lacking; only generic indications are available, without specific recommendations for different primary tumour locations (e.g. intrahepatic, extrahepatic biliary tract or gallbladder cancer). The aim of this study was to systematically review available literature to provide recommendations on lymph node target volume delineation in patients with unresectable biliary tumour...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28301292/reduce-adverse-effects-of-laparoscopic-cholecystectomy-with-pulse-width-modulated-led-light-625%C3%A2-nm-76%C3%A2-hz-23-duty-cycle
#15
Alexander V Redkin, Victor V Vdovin, Victor M Vakhtel, Pavel A Lukyanovich, Natalia A Malkina
OBJECTIVE: Reducing adverse effects in laparoscopic cholecystectomy (LCE) is important to avoid complications. After removal, the porta hepatis and gallbladder bed of liver were treated with pulse width modulated (PWM) red LED light with parameters λ = 625 ± 5 nm, full width at half maximum 17 nm, 76 Hz, duty cycle 23%, 15-30 mW/cm(2), and 0.9-1.8 J/cm(2). The changes of eight blood parameters were studied: red blood cell, hemoglobin, white blood cell, erythrocyte sedimentation rate (ESR), bilirubin, aspartate transaminase (AST), alanine transaminase (ALT), and amylase...
March 16, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28298384/correction-long-noncoding-rna-gcaspc-a-target-of-mir-17-3p-negatively-regulates-pyruvate-carboxylase-dependent-cell-proliferation-in-gallbladder-cancer
#16
(no author information available yet)
No abstract text is available yet for this article.
March 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28295868/ciap2-promotes-gallbladder-cancer-invasion-and-lymphangiogenesis-by-activating-the-nf-%C3%AE%C2%BAb-pathway
#17
Xiaojie Jiang, Chengzong Li, Bin Lin, Haijie Hong, Lei Jiang, Siyuan Zhu, Xiaoqian Wang, Nanhong Tang, Xiujin Li, Feifei She, Chen Yanling
Several studies have produced contradictory findings about the prognostic implications for inhibitor of apoptosis proteins (IAPs) in different types of cancer. Cellular inhibitor of apoptosis 2 (cIAP2/BIRC) is one of the most extensively characterized human IAPs. To date no studies have focused on the expression level of cIAP2 in human gallbladder cancer (GBC), and the mechanism of cIAP2 in GBC invasion and lymphangiogenesis remains unclear. Therefore, in the present study, cIAP2 expression in GBC was detected using qRT-PCR and immunohistochemistry, and the relationship between cIAP2 levels in cancer tissues and the clinicopathological characteristics of patients was analysed...
March 15, 2017: Cancer Science
https://www.readbyqxmd.com/read/28294161/in-vivo-imaging-of-the-muc5b-gel-forming-mucin
#18
Céline Portal, Valérie Gouyer, Mylène Magnien, Ségolène Plet, Frédéric Gottrand, Jean-Luc Desseyn
Gel-forming mucins are macromolecules produced by goblet cells and responsible for the mucus gel formation. Changes in goblet cell density and in gel-forming mucin production have emerged as sensitive indicators for mucosal diseases. A Muc5b-GFP tagged reporter mouse was used to assess Muc5b production in mouse tissues by immunofluorescence microscopy and fluorescent activity using stereromicroscopy and probe-based confocal laser endomicroscopy. Muc5b production was followed longitudinally by recording the fluorescent activity in vagina and in embryonic lung explants under stimulation by interleukin 13...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28288854/irinotecan-induced-bile-acid-malabsorption-is-associated-with-down-regulation-of-ileal-asbt-slc10a2-in-mice
#19
A-Xi Shi, Yan Zhou, Xiao-Yi Zhang, Yan-Shu Zhao, Hong-Yan Qin, Yan-Ping Wang, Xin-An Wu
Irinotecan, (CPT-11), an antitumor agent primarily used for the treatment of solid tumors, has often compromised clinical application due to the inducement of severe delay-onset diarrhea. Bile acid malabsorption (BAM) is widely accepted as the common cause of diarrhea. However, whether CPT-11-induced diarrhea has correlation with BAM is unknown. The aim of this study was to investigate the effect of CPT-11 on the bile acid homeostasis in mice. The mice were administrated with CPT-11 intravenously for four consecutive days...
March 10, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28288186/diet-and-biliary-tract-cancer-risk-in-shanghai-china
#20
Shakira M Nelson, Yu-Tang Gao, Leticia M Nogueira, Ming-Chang Shen, Bingsheng Wang, Asif Rashid, Ann W Hsing, Jill Koshiol
Trends in biliary tract cancer incidence rates have increased in Shanghai, China. These trends have coincided with economic and developmental growth, as well as a shift in dietary patterns to a more Westernized diet. To examine the effect of dietary changes on incident disease, we evaluated associations between diet and biliary tract cancers amongst men and women from a population-based case-control study in Shanghai, China. Biliary tract cancer cases were recruited from 42 collaborating hospitals in urban Shanghai, and population-based controls were randomly selected from the Shanghai Household Registry...
2017: PloS One
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