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https://www.readbyqxmd.com/read/29451278/united-european-gastroenterology-week-uegw-2017-25th-annual-conference-october-28-november-1-2017-barcelona-spain
#1
E Torramadé
The 25th United European Gastroenterology Week (UEGW), the largest European conference centered on diseases of the stomach, bowel, esophagus, liver, pancreas and gallbladder, was held in Barcelona, Spain. This 5-day meeting attracted over 13,000 delegates to share recent research in the treatment of gastrointestinal and liver diseases. The conference provided teaching material, workshops and live sessions to all the attendants. The reports will cover the latest research into treatments for these diseases.
November 2017: Drugs of Today
https://www.readbyqxmd.com/read/29451163/eus-guided-gallbladder-drainage-current-status-and-future-prospects
#2
EDITORIAL
Douglas G Adler
No abstract text is available yet for this article.
January 2018: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/29450669/association-of-tert-clptm1l-and-8q24-common-genetic-variants-with-gallbladder-cancer-susceptibility-and-prognosis-in-north-indian-population
#3
Saurabh Yadav, Abhijit Chandra, Ashok Kumar, Balraj Mittal
Gallbladder carcinoma (GBC) is one of the common malignancy of the biliary tract. Several genome wide and candidate gene studies have reported associations between multiple cancer types and single-nucleotide polymorphisms on 5p15.33 and 8q24.21 loci. However, predisposition potential of these genetic variants has not been assessed in GBC. We performed the present study to assess the potential of five polymorphisms on 5p15.33 and one on 8q24.21 locus in GBC risk and treatment response in patients undergoing chemoradiotherapy...
February 15, 2018: Biochemical Genetics
https://www.readbyqxmd.com/read/29448202/the-correlation-between-serum-chemokines-and-clinical-outcome-in-patients-with-advanced-biliary-tract-cancer
#4
Su Jin Lee, Jung Eun Kim, Seung Tae Kim, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Won Ki Kang, Young Suk Park, Ho Yeong Lim
BACKGROUND: Biliary tract cancers (BTCs) are known to have a dismal prognosis. A number of chemokines play important roles in the progress of BTCs. However, the serum levels of chemokines in BTCs have not yet been explored. METHODS: The sera of healthy donors (n = 8) and patients with BTCs who were enrolled in second line sunitinib trials (n = 27) were collected. The concentrations of three kinds of chemokines (CXCL5, CXCL8 and CXCL12) were measured using ELISA assay...
February 12, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29441475/robot-assisted-distal-gastrectomy-with-lymph-node-dissection-for-gastric-cancer-in-a-patient-with-situs-inversus-partialis-a-case-report-with-video-file
#5
Yuki Aisu, Yoshio Kadokawa, Shigeru Kato, Daiki Yasukawa, Yusuke Kimura, Tomohide Hori
BACKGROUND: Situs inversus is a rare congenital condition that is currently classified into two types: complete situs inversus (situs inversus totalis, SIT) and partial situs inversus (situs inversus partialis, SIP). In SIP patients, some organs are inverted and others are in their expected position, and individual patient variation in organ position increases surgical difficulty. Several surgeons have performed laparoscopic or robotic surgeries in situs inversus patients, but almost all were SIT patients...
February 13, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29441341/single-incision-laparoscopic-cholecystectomy-for-patients-with-mirizzi-syndrome
#6
Won-Bae Chang, Ho-Seong Han, Yoo-Seok Yoon, Jai Young Cho, YoungRok Choi
Since multiport laparoscopic cholecystectomy has become a standard treatment for gallbladder (GB) disease, a single incision laparoscopic surgical technique has been tried to decrease the surgical site pain and achieve a better cosmetic out come in selected patients. The development of devices dedicated for single incision laparoscopic cholecystectomy (SILC) is expanding the indication of this single incision laparoscopic technique to more complicated GB diseases. Mirizzi syndrome (MS) is one of the complex uncommon gallstone diseases in patients undergoing cholecystectomy...
February 2018: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29440242/bilobed-gallbladder-a-rare-congenital-anomaly
#7
Manoj Kumar, Devbrata Adhikari, Vineet Kumar, Satish Dharap
Bilobed gallbladder is a rare form of duplication of gallbladder. Preoperative diagnosis is important to avoid peroperative complications; however, it is also a challenge as imaging reports are often confounding. A case of bilobed gallbladder managed successfully laparoscopically is presented.
February 11, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29435905/neuroendocrine-carcinoma-of-gallbladder-a-step-beyond-palliative-therapy-experience-of-25-cases
#8
Amol Vijay Kanetkar, Shraddha Patkar, Krunal Harischandra Khobragade, Vikas Ostwal, Anant Ramaswamy, Mahesh Goel
PURPOSE: Published literature on gall bladder neuroendocrine tumors (GB NETs) is limited with none reporting the role of multimodal therapy. METHODS: Patients with histologically confirmed GB NETs treated at Tata Memorial Hospital, Mumbai, from January 2010 to June 2017 were analyzed. Staging was done by contrast-enhanced computed tomography (CECT) of abdomen and chest or a positron emission topography (PET) scan. Tumor marker (CA19-9) was measured. WHO-2017 guideline was used to classify GB NETs...
February 13, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29435072/mir-433-accelerates-acquired-chemoresistance-of-gallbladder-cancer-cells-by-targeting-cyclin-m
#9
Jianhua Yu, Weiguang Zhang, Baochun Lu, Hongwei Qian, Haijun Tang, Zhiyang Zhu, Xinggui Yuan, Peitu Ren
Resistance to chemotherapy is associated with dismal prognosis in patients with gallbladder cancer. Cyclin-dependent kinase 10 (CDK10) influences the chemosensitivity of gallbladder cancer cells, and cyclin M is the activating factor and binding partner of CDK10. To determine the effect of CDK10 or cyclin M overexpression on chemosensitivity, gemcitabine-resistant (GR) subclones were established from CDK10 or cyclin M stable transfectants. Stable overexpression of CDK10 increased the sensitivity to gemcitabine in non-resistant cells and did not further increase the sensitivity to gemcitabine in the GR subclones...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434721/downregulation-of-nima-related-kinase-7-inhibits-cell-proliferation-by-inducing-cell-cycle-arrest-in-human-retinoblastoma-cells
#10
Jian Zhang, Li Wang, Yongkang Zhang
NIMA-related kinase-7 (Nek7) is a centrosomal kinase involved in various types of cancer, including gallbladder cancer and hepatocellular carcinoma. However, the biological function and the potential underlying mechanism of Nek7 in retinoblastoma remain largely unknown. Therefore, the present study investigated the effects of Nek7 in retinoblastoma cells. The expression of Nek7 was initially determined and observed to be commonly upregulated in retinoblastoma cell lines (Y79, SO-RB50 and WERI-RB1) as compared with that in normal retinal pigment epithelium cells...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29432979/a-novel-multi-atlas-strategy-with-dense-deformation-field-reconstruction-for-abdominal-and-thoracic-multi-organ-segmentation-from-computed-tomography
#11
Bruno Oliveira, Sandro Queirós, Pedro Morais, Helena R Torres, João Gomes-Fonseca, Jaime C Fonseca, João L Vilaça
Anatomical evaluation of multiple abdominal and thoracic organs is generally performed with computed tomography images. Owing to the large field-of-view of these images, automatic segmentation strategies are typically required, facilitating the clinical evaluation. Multi-atlas segmentation (MAS) strategies have been widely used with this process, requiring multiple alignments between the target image and the set of known datasets, and subsequently fusing the alignment results to obtain the final segmentation...
February 2, 2018: Medical Image Analysis
https://www.readbyqxmd.com/read/29432055/minimally-invasive-pediatric-cholecystectomy-a-comparison-of-robotic-and-laparoscopic-single-and-multiport-techniques
#12
Heather Nolan, Joshua Glenn
BACKGROUND: Pediatric laparoscopic cholecystectomy is the current standard of care for gallbladder pathology. Single-incision and multiport procedures, as well as robotic and minimally invasive platforms, have been described; however, there is no head-to-head assessment of these interventions in the existing literature. The purpose of our study was to directly compare the minimally invasive cholecystectomy techniques of laparoscopic multiport (LMP), laparoscopic single incision (LSI), robotic multiport (RMP), and robotic single incision (RSI)...
February 12, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29428040/evaluation-of-the-safety-and-efficacy-of-percutaneous-transhepatic-gallbladder-drainage-combined-with-laparoscopic-cholecystectomy-for-treating-acute-complicated-cholecystitis
#13
Baoxing Jia, Kai Liu, Ludong Tan, Zhe Jin, Yu Fu, Yahui Liu
The rate of acute cholecystitis in patients with severe underlying diseases is currently increasing. Several studies have reported percutaneous transhepatic gallbladder drainage (PTGBD) combined with laparoscopic cholecystectomy (LC) as a safe and reliable therapeutic option in such patients. This study aimed to elucidate the optimal time interval between PTGBD and LC. In total, 65 patients with acute complicated cholecystitis from our hospital were divided into two groups, short-term LC (sLC) and postponed LC (pLC) group according to whether the procedure was performed within 5 days of gallbladder drainage or after 5 days, respectively...
January 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29427256/laparoscopic-cholangiogram-in-biliary-atresia-a-refinement-in-the-gallbladder-hitch-technique
#14
Ravi Kishore, Sundeep M C Kisku, Reju Joseph Thomas, Srinivasa Kishore Jeenipalli
INTRODUCTION: The study describes a refinement in the gallbladder hitch stitch and assesses the value of the laparoscopic cholangiogram in children with suspected biliary atresia. METHODS: Twenty children with neonatal jaundice and no drainage as shown on the HIDA scan underwent a diagnostic laparoscopy through an umbilical 5 mm port. A 3 mm laparoscopic needle holder inserted through a 3.5 mm port to the left of the umbilicus was used to hitch the gallbladder to the abdominal wall...
February 9, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29426789/management-and-treatment-of-gallbladder-polyps
#15
Marina Vila, Laura Lladó, Emilio Ramos
No abstract text is available yet for this article.
February 6, 2018: Medicina Clínica
https://www.readbyqxmd.com/read/29423157/acute-cholecystitis-in-a-parastomal-hernia-causing-a-small-bowel-obstruction
#16
Chetna Bakshi, Samantha Ruff, Frank Caliendo, Jennifer Agnew
A parastomal hernia is the abnormal protrusion of intra-abdominal tissue and organs through a defect in the abdominal wall around an ostomy. Commonly, they involve intra-abdominal fat, omentum or bowel. However, there are rare cases that involve other organs. We present the case of an 89-year-old gentleman with a gallbladder in his parastomal hernia. Due to his acute cholecystitis, the distended gallbladder compressed adjacent bowel loops in the parastomal hernia, resulting in a mechanical bowel obstruction...
December 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29417247/predicting-conversion-from-laparoscopic-to-open-cholecystectomy-a-single-institution-retrospective-study
#17
Samer Al Masri, Yaser Shaib, Mostapha Edelbi, Hani Tamim, Faek Jamali, Nicholas Batley, Walid Faraj, Ali Hallal
BACKGROUND: Laparoscopic cholecystectomy (LC) is the standard surgical treatment for benign gallbladder disease. Nevertheless, conversion to open cholecystectomy (OC) is needed in some cases. The aim of this study is to calculate our institutional conversion rate and to identify the variables that are implicated in increasing the risk of conversion (LC-OC). MATERIALS AND METHODS: We carried out a retrospective study of all cases of LC performed at the American University of Beirut Medical Center between 2000 and 2015...
February 7, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29416916/genotyping-and-mrna-profiling-reveal-actionable-molecular-targets-in-biliary-tract-cancers
#18
Kyriaki Papadopoulou, Samuel Murray, Kyriaki Manousou, Ioannis Tikas, Christos Dervenis, Joseph Sgouros, Dimitra Rontogianni, Sotirios Lakis, Mattheos Bobos, Christos Poulios, Stavroula Pervana, Georgios Lazaridis, George Fountzilas, Vassiliki Kotoula
Biliary tract cancer (BTC) represents a heterogeneous disease with dismal outcome. Herein, we examined genotype and angiogenesis features in BTC. We applied genotyping (Sanger, qPCR, 101-gene panel NGS), mRNA relative quantification methods, and β-catenin immunohistochemistry in 84 FFPE BTC (55 gallbladder [GBC], 14 intrahepatic [ICC], 15 extrahepatic [ECC] carcinomas). We identified 541 mutations in 68 (81%) tumors. Top mutated genes were CTNNB1 (36%); PTEN (33%); TP53 (31%); PIK3R1 (29%); PIK3CA (13%); BRCA2 and KRAS (12%); BRCA1 (11%)...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29416013/mir-143-3p-targeting-of-itga6-suppresses-tumour-growth-and-angiogenesis-by-downregulating-plgf-expression-via-the-pi3k-akt-pathway-in-gallbladder-carcinoma
#19
Yun-Peng Jin, Yun-Ping Hu, Xiang-Song Wu, Yao-Shi Wu, Yuan-Yuan Ye, Huai-Feng Li, Yong-Chen Liu, Lin Jiang, Fa-Tao Liu, Yi-Jian Zhang, Ya-Juan Hao, Xi-Yong Liu, Ying-Bin Liu
Gallbladder cancer (GBC) is the most common malignant tumour of the biliary track system. Angiogenesis plays a pivotal role in the development and progression of malignant tumours. miR-143-3p acts as a tumour suppressor in various cancers. Their role in GBC is however less well defined. Here we show that the expression levels of miR-143-3p were decreased in human GBC tissues compared with the non-tumour adjacent tissue (NAT) counterparts and were closely associated with overall survival. We discovered that miR-143-3p was a novel inhibitor of tumour growth and angiogenesis in vivo and in vitro...
February 7, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29415686/prenatal-and-accurate-perinatal-diagnosis-of-type-2-h-or-ductular-duplicate-gallbladder
#20
Umberto Maggi, Giorgio Farris, Alessandra Carnevali, Irene Borzani, Paola Clerici, Massimo Agosti, Giorgio Rossi, Ernesto Leva
BACKGROUND: Double gallbladder is a rare biliary anomaly. Perinatal diagnosis of the disorder has been reported in only 6 cases, and in 5 of them the diagnosis was based on ultrasound imaging only. However, the ultrasound technique alone does not provide a sufficiently precise description of cystic ducts and biliary anatomy, an information that is crucial for a correct classification and for a possible future surgery. CASE PRESENTATION: At 21 weeks of gestational age of an uneventful pregnancy in a 38 year old primipara mother, a routine ultrasound screening detected a biliary anomaly in the fetus suggestive of a double gallbladder...
February 7, 2018: BMC Pediatrics
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