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https://www.readbyqxmd.com/read/28813731/a-case-of-fulminant-hepatic-failure-secondary-to-congestive-heart-failure-without-evidence-of-acute-cardiac-decompensation
#1
Kalyan Wagle, Oluwaseun A Akinseye, Prakash Shrestha, Madhuri Chandnani, Raiko Munankarmi, Vivian Ripin, Jimmy Yee
There are so far only a few reported cases of acute fulminant hepatic failure resulting from acute cardiomyopathy. This is a rare occurrence, especially in patients that do not exhibit any signs and symptoms of acute cardiac decompensation. We report a case of fulminant liver failure with nondiagnostic work up for the common causes of liver failure. This patient had concurrent history of congestive heart failure, but did not have acute decompensation. Right upper quadrant sonogram revealed hepatomegaly of 15 cm, trace amount of perihepatic ascites, pericholecystic fluid, and also thickened edematous gallbladder wall with no stones, no common bile duct stones, and no portal vein thrombosis...
April 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28813430/reprogramming-human-gallbladder-cells-into-insulin-producing-%C3%AE-like-cells
#2
Feorillo Galivo, Eric Benedetti, Yuhan Wang, Carl Pelz, Jonathan Schug, Klaus H Kaestner, Markus Grompe
The gallbladder and cystic duct (GBCs) are parts of the extrahepatic biliary tree and share a common developmental origin with the ventral pancreas. Here, we report on the very first genetic reprogramming of patient-derived human GBCs to β-like cells for potential autologous cell replacement therapy for type 1 diabetes. We developed a robust method for large-scale expansion of human GBCs ex vivo. GBCs were reprogrammed into insulin-producing pancreatic β-like cells by a combined adenoviral-mediated expression of hallmark pancreatic endocrine transcription factors PDX1, MAFA, NEUROG3, and PAX6 and differentiation culture in vitro...
2017: PloS One
https://www.readbyqxmd.com/read/28807199/prediction-of-difficult-laparoscopic-cholecystectomy-for-acute-cholecystitis
#3
Hiromitsu Maehira, Masayasu Kawasaki, Aya Itoh, Masao Ogawa, Naoto Mizumura, Sho Toyoda, Satoshi Okumura, Masao Kameyama
BACKGROUND: No report has described the predictive factor of surgical difficulty for laparoscopic cholecystectomy (LC) by preoperative computed tomography (CT) findings. This study aimed to investigate whether dynamic CT findings can predict the difficulty of LC for acute cholecystitis. MATERIALS AND METHODS: Fifty-seven patients who underwent emergency LC and dynamic CT preoperatively were enrolled. Difficult LC (DLC) was defined as any patient with an operative time ≥3 h, bleeding volume ≥300 mL, common bile duct injury, partial cholecystectomy, the need for a second surgeon, and/or conversion to open surgery...
August 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28803397/is-concomitant-cholecystectomy-necessary-for-asymptomatic-cholelithiasis-during-laparoscopic-sleeve-gastrectomy
#4
Samet Yardimci, Mumin Coskun, Salih Demircioglu, Aylin Erdim, Asim Cingi
BACKGROUND: There is not any consensus on concomitant cholecystectomy for asymptomatic gallbladder stones during laparoscopic sleeve gastrectomy (LSG). The aim of this study was to evaluate the surveillance results of the LSG patients who have asymptomatic gallbladder stones and did not undergo cholecystectomy. METHODS: Patients who underwent laparoscopic sleeve gastrectomy with preoperatively detected gallbladder stones and completed at least 6 months follow-up were included in the study...
August 12, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28803245/mir-143-5p-deficiency-triggers-emt-and-metastasis-by-targeting-hif-1%C3%AE-in-gallbladder-cancer
#5
Min He, Ming Zhan, Wei Chen, Sunwang Xu, Manmei Long, Hui Shen, Yongheng Shi, Qiang Liu, Man Mohan, Jian Wang
BACKGROUND/AIMS: Early metastasis plays a pivotal role in tumor-caused death in gallbladder cancer (GBC) patients. Increasing evidence suggest that miR-143-5p is an active player involved in cancer metastasis and a potential therapeutic target. However, its role in the development of GBC cells remains unclear. The aim of this study is to reveal the inhibiting effects of miR-143-5p on the proliferation and metastasis in GBC. METHODS: Quantitative real-time PCR were used to investigate miR-143-5p and its target HIF-1α mRNA levels...
August 11, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28803124/influence-of-depth-of-neuromuscular-blockade-on-surgical-conditions-during-low-pressure-pneumoperitoneum-laparoscopic-cholecystectomy-a-randomized-blinded-study
#6
Javier Barrio, Carlos L Errando, Jaime García-Ramón, Rafael Sellés, Guillermo San Miguel, Juan Gallego
STUDY OBJECTIVE: To evaluate the influence of neuromuscular blockade (NMB) on surgical conditions during low-pressure pneumoperitoneum (8mmHg) laparoscopic cholecystectomy (LC), while comparing moderate and deep NMB. Secondary objective was to evaluate if surgical conditions during low-pressure pneumoperitoneum LC performed with deep NMB could be comparable to those provided during standard-pressure pneumoperitoneum (12mmHg) LC. DESIGN: Prospective, randomized, blinded clinical trial...
August 10, 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28803070/sex-disparities-in-cancer-incidence-in-jiashan-county-china-1995-2014
#7
Xiyi Jiang, Shaofang Cai, Yunqing Hu, Ding Ye, Qilong Li, Kun Chen, Mingjuan Jin
PURPOSE: To describe the sex-specific incidence rates and the male-to-female incidence-rate ratios (IRRs) of different cancer types, and to explore the corresponding sex disparities in an area of Eastern China. METHODS: We used data from the Cancer Registry in Jiashan County, and calculated the sex-specific age-standardized (2010 China standard population) incidence rates and the male-to-female IRRs for different cancer types during the period 1995-2014. RESULTS: The age-standardized incidence rates of all cancers for the whole period 1995-2014 were 151...
August 10, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28802164/agenesis-of-gall-bladder-in-laparoscopic-cholecystectomy-a-case-report
#8
Samer Makki Mohamed Al-Hakkak
INTRODUCTION: Agenesis of gallbladder is a rare congenital anomaly of biliary tree that may be associated with other biliary and extra biliary congenital anomalies. CASE PRESENTATION: A 43- year- old female presented with a 4 months history of upper abdominal pain associated with nausea and vomiting. It was associated with dyspeptic symptoms and become worse following ingestion of high-fat meal contents. Clinically, a differential of gall stone disease was considered...
August 3, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28798003/neuroendocrine-carcinoma-of-gall-bladder-a-rare-presentation-with-review-of-literature
#9
Amit Gupta, Parvez Ahmed, Prashant Durgapal, Pooja Kala, Shalinee Rao, Rajesh Pasricha, Sanjeev Misra
Neuroendocrine tumors are the rarest tumors of gallbladder. The most aggressive variant is neuroendocrine carcinoma which presents in about 0.5% of all gallbladder carcinomas and 0.2% of all neuroendocrine tumors. It seems possible that survival rates can be improved by utilizing wide surgical resection combined with chemotherapy. We report a case of neuroendocrine carcinoma of gall bladder in a 20-year old female patient. In present case, the etiology was not known as patient did not have cholelithiasis or any symptoms related to chronic inflammation...
May 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28795384/contribution-of-hepatobiliary-scintigraphy-in-assessing-alpps-most-suited-timing
#10
Stéphanie Truant, Clio Baillet, Anne Claire Deshorgue, Mehdi El Amrani, Damien Huglo, François-René Pruvot
To reduce post-hepatectomy liver failure (PHLF), associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has been recently developed for patients with a limited future remnant liver (FRL). Nevertheless, high morbi-mortality rates have been reported . The current study aimed to analyze the kinetics of FRL function in patients who were offered ALPPS. Serial SPECT (99 m)Tc-mebrofenin hepatobiliary scintigraphy (HBS) was performed in all patients before and after surgery as well as at inter-stage to quantitatively assess hepatic function [total liver (TL) and FRL]...
August 9, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28795070/an-interesting-case-of-a-bilious-pleural-effusion
#11
Christoffel van Niekerk, Kelly Fan, Anna Sarcon, Bao Luu
Malignant pleural effusions are common complications in patients with primary or metastatic cancer to the lungs. In this article, we describe a unique case of a patient with history of diffuse pulmonary metastases from gallbladder adenocarcinoma who acutely developed a bilious pleural effusion following endoscopic retrograde cholangiopancreatography. We believe the bilious pleural effusion (cholethorax or bilothorax) developed as a complication of endoscopic retrograde cholangiopancreatography rather than tumor burden causing a fistula from the biliary tree to the right pleural space...
July 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28795059/inferior-vena-cava-reconstruction-by-gallbladder-patch-an-experimental-design
#12
Hossein Hodjati, Sahar Sohrabi Nazari, Seifollah Dehghani Nazhvani, Mohammad Yasin Karami, Bita Geramizadeh
OBJECTIVE: To evaluate the efficacy of the gallbladder for reconstruction of the inferior vena cava in a canine model. METHODS: The experimental study was conducted on 5 dogs; an oval window with a diameter of (4×1 cm) was made in the inferior vena cava and then repaired using the autologous gallbladder patch with preservation of gallbladder function. The patency and functionality of the graft were assessed macroscopically and microscopically at 2 months postoperatively...
July 2017: Bulletin of Emergency and Trauma
https://www.readbyqxmd.com/read/28792798/cholecystopexy-and-pericardial-pseudocyst-removal-in-a-dog-with-a-congenital-peritoneopericardial-diaphragmatic-hernia
#13
Quentin Cabon, Eric Norman Carmel, Julien Cabassu
A 4 mo old spayed female golden retriever was presented with a peritoneopericardial diaphragmatic hernia (PPDH) that was diagnosed during neutering. Echocardiography revealed a fluid-filled structure and parts of the liver in the pericardial cavity. Computed tomography confirmed the existence of the PPDH and the herniation of the right medial liver lobe and the gallbladder. Cystic masses were observed in the pericardial and the peritoneal cavities, possibly communicating through the PPDH. A median laparotomy revealed a single lobulated cystic lesion extending into both the pericardial and peritoneal cavities through the PPDH...
August 9, 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/28792158/robotic-cholecystectomy-using-the-newly-developed-korean-robotic-surgical-system-revo-i-a-preclinical-experiment-in-a-porcine-model
#14
Chang Moo Kang, Jae Uk Chong, Jin Hong Lim, Dong Won Park, Sung Jun Park, Suhyeon Gim, Hye Jin Ye, Se Hoon Kim, Woo Jung Lee
One Korean company recently successfully produced a robotic surgical system prototype called Revo-i (MSR-5000). We, therefore, conducted a preclinical study for robotic cholecystectomy using Revo-i, and this is a report of the first case of robotic cholecystectomy performed using the Revo-i system in a preclinical porcine model. Revo-i consists of a surgeon console (MSRC-5000), operation cart (MSRO-5000) and vision cart (MSRV-5000), and a 40 kg-healthy female porcine was prepared for robotic cholecystectomy with general anesthesia...
September 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28791325/survey-study-on-the-practice-patterns-in-the-endoscopic-management-of-malignant-distal-biliary-obstruction
#15
Dennis Yang, Yaseen B Perbtani, Qi An, Mitali Agarwal, Michael Riverso, Joydeep Chakraborty, Tony S Brar, Donevan Westerveld, Han Zhang, Shailendra S Chauhan, Christopher E Forsmark, Peter V Draganov
BACKGROUND AND STUDY AIM:  Endoscopic biliary drainage for malignant distal biliary obstruction (MDBO) is a common practice. Controversy persists with regard to its role in resectable MDBO, the optimal technical method and type of stent. The aim of this study was to evaluate practice patterns in the treatment of MDBO among endoscopists with varying levels of experience and practice backgrounds. METHODS:  Electronic survey distributed to members of the American Society for Gastrointestinal Endoscopy (ASGE)...
August 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28789598/development-of-a-computerized-4-d-mri-phantom-for-liver-motion-study
#16
Chunhao Wang, Fang-Fang Yin, W P Segars, Zheng Chang, Lei Ren
PURPOSE: To develop a 4-dimensional computerized magnetic resonance imaging phantom with image textures extracted from real patient scans for liver motion studies. METHODS: The proposed phantom was developed based on the current version of 4-dimensional extended cardiac-torso computerized phantom and a clinical magnetic resonance scan. Initially, the extended cardiac-torso phantom was voxelized in abdominal-chest region at the end of exhalation phase. Structures/tissues were classified into 4 categories: (1) Seven key textured organs, including liver, gallbladder, spleen, stomach, heart, kidneys, and pancreas, were mapped from a clinical T1-weighted liver magnetic resonance scan using deformable registration...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28782883/gallbladder-mucosal-lesions-associated-with-high-biliary-amylase-irrespective-of-pancreaticobiliary-maljunction
#17
Jason Free, Frank Wang, Nick Williams, Justin S Gundara, Ralph F Staerkle, Thomas J Hugh, Jaswinder S Samra
BACKGROUND: Previous studies have focused on the presence of reflux in selected cohorts with pancreaticobiliary maljunction (PBM), but little is known regarding the wider incidence of occult reflux and associated mucosal changes. We aimed to correlate gallbladder mucosal abnormalities with objective evidence of PBM and occult pancreaticobiliary reflux (PBR) in an Australian population undergoing cholecystectomy. METHODS: Patients undergoing cholecystectomy between September 2010 and September 2012 were eligible for inclusion...
August 7, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28782749/gall-bladder-flip-technique-in-laparoscopic-cholecystectomy
#18
Munish Sharma, Anubhav Vindal, Pawanindra Lal
BACKGROUND: The precise steps for the removal of gall bladder from the gall bladder bed are not well standardised. The dissection becomes more difficult near the fundus where the assistant's grasper holding the fundus creates a 'tug of war' like situation. MATERIALS AND METHODS: This is a description of a simple technique that aids in accurate dissection of the gallbladder from liver bed. As the gallbladder dissection approaches fundus and more than two-third of gallbladder is dissected from liver bed, the medial and lateral peritoneal folds of gall bladder are further incised...
August 1, 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/28782743/laparoscopic-versus-open-treatment-of-gallbladder-cancer-a-systematic-review-and-meta-analysis
#19
Xin Zhao, Xiang Yang Li, Wu Ji
BACKGROUND: The aim of this review was to evaluate the effect of laparoscopic surgery on the treatment of patients with gallbladder cancer (GBC). METHODS: A comprehensive search of Medline and Cochrane Library was conducted to identify relevant articles. A meta-analysis was subsequently performed. RESULTS: A total of 20 studies including 1217 patients met the inclusion criteria. The meta-analysis showed that the 5-year survival rate was significant higher in laparoscopic group than open group (48...
August 1, 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/28782079/lymph-node-micrometastasis-in-gallbladder-cancer
#20
Swati H Shah, Nikhil Gupta, Gurudutt Gupta, Anurag Mehta, Shivendra Singh
BACKGROUND: Prognosis of gallbladder cancer (GBC) is grim even after curative surgery. Lymph node metastasis is the most important prognostic factor, but distant relapses occurring in their absence point towards additional factor. Lymph node micrometastasis could be one. The present study aimed to evaluate the incidence and clinical significance of lymph node micrometastasis. METHODS: This is a prospective study of patients undergoing curative surgery for GBC from 1 March 2013 to 30 April 2015, at our institute...
August 7, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
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