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Kalpesh Parmar, Sahaj Rathi, Ashish Khanna, Mukesh Gupta, Akash Singh, S K Singh, Virendra Singh
Portosystemic collaterals are common sequelae of portal hypertension. These often present as gastroesophageal varices. Ectopic varices can rarely be seen in duodenum, jejunum, rectum, and sites of surgical anastomoses. Bladder varices are extremely rare presenting with recurrent hematuria, with only a few reported cases. We report here management of an unusual case of hematuria managed with blood transfusion, intravenous terlipressin and endoscopic N-butyl cyanoacrylate glue injection.
March 13, 2018: Urology
Jacob B Hall, Zhaoyuan Cong, Yuka Imamura-Kawasawa, Brian A Kidd, Joel T Dudley, Diane M Thiboutot, Amanda M Nelson
Our understanding of the microbiome and the role of P. acnes in skin homeostasis and acne pathogenesis is evolving. Multiple methods for sampling and identifying the skin's microbiome exist and understanding the differences between the abilities of various methods to characterize the microbial landscape is warranted. This study compared the microbial diversity of samples obtained from the cheeks of twenty volunteers, collected by surface swab, pore strips, and cyanoacrylate glue follicular biopsy, all sequenced with 16S rRNA sequencing (V1-V3) and whole-genome metagenomic sequencing (WGS)...
March 13, 2018: Journal of Investigative Dermatology
Ezio Lanza, Riccardo Muglia, Luigi Alessandro Solbiati, Marco Tramarin, Dario Poretti, Vittorio Pedicini
BACKGROUND: The aim of this study is to report the results of transarterial embolization (TAE) in the setting of postoperative bleeding after hip surgery. METHODS: We retrospectively evaluated 40 patients (male:female = 15:25, median age = 68 years) who underwent TAE from 2006 to 2016: 77.5% underwent total hip arthroplasty, 20% open reduction internal fixation, and 2.5% external fixation. Preangiographic multidetector computed tomography angiography was performed in 20 (49%) cases, and 9 of them showed arterial extravasation...
February 15, 2018: Journal of Arthroplasty
Wibke Uller, Sherif El-Sobky, Ahmad I Alomari, Steven J Fishman, Samantha A Spencer, Amir H Taghinia, Gulraiz Chaudry
PURPOSE: The purpose of this study was to evaluate the safety and efficacy of preoperative percutaneous n-butyl cyanoacrylate (nBCA) embolization of venous malformations in children. MATERIAL AND METHODS: Clinical data were retrospectively reviewed in children who underwent embolization using nBCA followed by resection of venous malformations. RESULTS: A total of 17 embolizations were performed in 14 patients (9 females, mean age: 5.5 years; median age: 3 years; range 0...
January 1, 2018: Vascular and Endovascular Surgery
Yusuke Hashimoto, Izumi Ohno, Hideaki Takahashi, Mitsuhito Sasaki, Hiroshi Imaoka, Kazuo Watanabe, Kumiko Umemoto, Gen Kimura, Shuichi Mitsunaga, Masafumi Ikeda
No abstract text is available yet for this article.
March 12, 2018: Endoscopic Ultrasound
Ikram Hussain, Andrew Eu Boon Kwek, Veeraraghavan Meyyur Aravamudan, Chern Hao Chong, Tiing Leong Ang
Background . Injection with N-butyl-2-cyanoacrylate is a proven and successful therapeutic modality for treatment of patients with bleeding gastric varices. However, a variety of complications have also been associated with its use. Here, we report a rare case of retrogastric abscess which occurred almost six months after this therapy. This abscess was attributed to the hampered microbial clearance caused by the venous obliterations from N-butyl-2-cyanoacrylate. The abscess was successfully treated with 3 months of antibiotics...
2018: Case Reports in Medicine
Takahiro Tadokoro, Manabu Kakinohana, Michael Navarro, Motoaki Goya, Yuichiro Odo
BACKGROUND: Insufficient fixation of an epidural catheter may result in migration of the catheter and eventual catheter failure. However, the best fixation method remains to be established. Aron Alpha A (2-ethyl cyanoacrylate) adhesive is approved for clinical use and can be used for surgical adhesion to both skin and blood vessels. We hypothesized that the addition of Aron Alpha A adhesive to film dressing would result in consistent and dependable catheter fixation. METHODS: In this study, 58 women who were scheduled for cesarean delivery under spinal and epidural anesthesia were recruited...
March 12, 2018: Anesthesia and Analgesia
Taressa Bull, Amanda Corley, Danielle J Smyth, David J McMillan, Kimble R Dunster, John F Fraser
BACKGROUND: Extracorporeal membrane oxygenation (ECMO) delivers cardiac and/or respiratory support to critically ill patients who have failed conventional medical therapies. If the large-bore cannulas used to deliver ECMO become infected or dislodged, the patient consequences can be catastrophic. ECMO cannula-related infection has been reported to be double the rate of other vascular devices (7.1 vs 3.4 episodes/1000 ECMO days respectively). The aim of this study was to assess the ability of cyanoacrylate tissue adhesive (TA) to inhibit bacterial growth at the ECMO cannulation site, and the effectiveness of TA and securement devices in securing ECMO cannulas and tubing...
March 12, 2018: Intensive Care Medicine Experimental
Alicia Khuu, Scott Chadwick, Sébastien Moret, Xanthe Spindler, Peter Gunn, Claude Roux
Fingermarks can be exploited for both their ridge detail and touch DNA. One-step luminescent cyanoacrylate (CA) fuming techniques used for fingermark enhancement, such as PolyCyano UV (Foster+Freeman Ltd) and Lumicyano™ (Crime Science Technology), claim to be compatible with DNA analysis as they reduce the need for post-staining to increase contrast of the developed fingermark. The aim of this study was to determine the impact that these one-step luminescent cyanoacrylates have on DNA analysis and how they compare to conventional CA techniques...
February 23, 2018: Forensic Science International
Eva K B Pfannes, Lina Weiss, Sabrina Hadam, Jessica Gonnet, Béhazine Combardière, Ulrike Blume-Peytavi, Annika Vogt
The success of topically applied treatments on skin relies on the efficacy of skin penetration. In order to increase particle or product penetration, mild skin barrier disruption methods can be used. We previously described cyanoacrylate skin surface stripping as an efficient method to open hair follicles, enhance particle penetration, and activate Langerhans cells. We conducted ex vivo and in vivo measurements on human skin to characterize the biological effect and quantify barrier disruption-related inflammation on a molecular level...
March 7, 2018: Skin Pharmacology and Physiology
Mohammed A Almustafa, Alistair M Ewen, Angela H Deakin, Frederic Picard, Jon V Clarke, Fahd F Mahmood
BACKGROUND: Surgical site infection (SSI) is a debilitating complication of lower limb arthroplasty with significant morbidity and increased costs. Numerous risk factors are associated with SSI. METHODS: In an effort to identify novel risk factors for SSI, we undertook a retrospective cohort study of 1832 primary total hip arthroplasties and 2100 primary total knee arthroplasties performed in our high volume arthroplasty unit over a 2-year period. RESULTS: Two risk factors were identified for SSI following total hip arthroplasty: body mass index ≥30 and peri-operative blood transfusion...
January 31, 2018: Journal of Arthroplasty
Daniel F Geersen, Cynthia E K Shortell
Ambulatory phlebectomy is a well-known and widely used procedure for residual symptomatic venous disease. Tumescent anesthesia complements the procedure, providing the ability to perform this intervention in a wide range of practice settings. The procedures are well tolerated by most patients, and complications are rare. They include venous thromboembolism, infection, and hematoma and are generally simple to manage. Alternative and emerging techniques of powered phlebectomy and cyanoacrylate glue are providing alternative forms for treatment and will advance the practice further...
April 2018: Surgical Clinics of North America
Daniel da Costa, Cristián Montenegro, Patricio Palavecino, Germán Lobos, Tomás Cermenati, Jaime Poniachik
Management of gastrointestinal bleeding caused by fundal varices is particularly difficult to manage. The options are: transjugular intrahepatic portosystemic shunt (TIPS), endoscopic injection of cyanoacrylate or balloon-occluded retrograde transvenous obliteration (BRTO). We report a 63 year-old male with a cirrhosis caused by hepatitis C and a 66 year-old female with a cirrhosis caused by a non-alcoholic steatohepatitis. Both patients had a gastrointestinal bleeding caused by fundal varices and were treated with sclerotherapy with cyanoacrylate assisted with BRTO...
October 2017: Revista Médica de Chile
A Boyde
Laser ablation machining or microtomy (LAM) is a relatively new approach to producing slide mounted sections of translucent materials. We evaluated the method with a variety of problems from the bone, joint and dental tissues fields where we require thin undecalcified and undistorted sections for correlative light microscopy (LM) and backscattered electron scanning electron microscopy (BSE SEM). All samples were embedded in poly-methylmethacrlate (PMMA) and flat block surfaces had been previously studied by BSE-SEM and confocal scanning light microscopy (CSLM)...
February 27, 2018: Journal of Microscopy
Akinari Abe, Miyuki Saito, Wesam R Kadhum, Hiroaki Todo, Kenji Sugibayashi
Development of an appropriate method to evaluate drug disposition or targeting ability in hair follicles (HFs) is urgently needed in order to develop useful pharmaceutical products with pharmacological effects in HFs. In the present study, a cyanoacrylate biopsy (CB) method was used to measure drug disposition in HFs using a model hydrophilic drug, caffeine (CAF), and a lipophilic drug, 4-butylresorcinol (BR), in excised porcine skin. As a result, the height of HF replicas and the recovery ratio decreased with an increase in the application times of the CB method...
February 19, 2018: International Journal of Pharmaceutics
Hannah Hill, Jeffrey Forris Beecham Chick, Anthony Hage, Ravi N Srinivasa
The purpose of this article is to describe acute complications associated with adhesive cyanoacrylate deposition in the peripheral circulation and their management. Despite best efforts, n-butyl cyanoacrylate glue embolization is inherently unpredictable and complications do occur. An understanding of preparation techniques that minimize adverse event rates and the technical skillset required to manage complications are necessary for the safe and efficient use of liquid embolic agents.
February 21, 2018: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
Cormac Duffy, Per B Zetterlund, Fawaz Aldabbagh
Cyanoacrylates (CAs) are well-known fast-setting adhesives, which are sold as liquids in the presence of stabilizers. Rapid anionic polymerization on exposure to surface moisture is responsible for instant adhesion. The more difficult, but synthetically more useful radical polymerization is only possible under acidic conditions. Recommendations on the handling of CAs and the resulting polymers are provided herein. In this review article, after a general description of monomer and polymer properties, radical homo- and copolymerization studies are described, along with an overview of nanoparticle preparations...
February 20, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Issei Takeuchi, Yukari Hida, Kimiko Makino
BACKGROUND: Nanoparticles with a diameter of 100-150 nm prepared using poly(lactide-co-glycolide) can be delivered to hair follicles. Moreover, it was shown that drug release from nanoparticles was prolonged by using poly(L-lactide-co-glycolide) (PLLGA). OBJECTIVE: The aim of this study was to prepared minoxidil-encapsulated PLLGA nanoparticles and accumulate minoxidil in hair follicles utilizing its drug delivery properties for effective treatment of male and female androgenetic alopecia...
2018: Bio-medical Materials and Engineering
Y Li, J Liang, Y Cheng, Q Zhang, X Ren, Y Sheng
OBJECTIVES: Although a number of methods have been attempted to improve securing the graft, packing gelfoam in the middle ear cavity cannot be avoided, which could obstruct the tympanic ostium of the Eustachian tube and affect inner ear function. Myringoplasty using tissue adhesive has gained traction because tissue adhesives can effectively stabilise the graft and act as scaffolding to improve the graft uptake. The aim of this prospective study was to explore myringoplasty using cyanoacrylate glue with no packing in the middle ear cavity for the repair of subtotal tympanic membrane (TM) perforations...
February 12, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
Joshua J Sutton, Jonathan E Barnsley, Joseph I Mapley, Pawel Wagner, David L Officer, Keith C Gordon
A series of eight carbazole-cyanoacrylate based donor-acceptor dyes were studied. Within the series the influence of modifying the thiophene bridge, linking donor and acceptor and a change in the nature of the acceptor, from acid to ester, was explored. In this joint experimental and computational study we have used electronic absorbance and emission spectroscopies, Raman spectroscopy and computational modeling (density functional theory). From these studies it was found that extending the bridge length allowed the lowest energy transition to be systematically red shifted by 0...
February 14, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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