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https://www.readbyqxmd.com/read/27914536/real-time-imaging-of-the-growth-inhibitory-effect-of-js399-19-on-fusarium
#1
Rasmus D Wollenberg, Søren S Donau, Thorbjørn T Nielsen, Jens L Sørensen, Henriette Giese, Reinhard Wimmer, Teis E Søndergaard
Real-time imaging was used to study the effects of a novel Fusarium-specific cyanoacrylate fungicide (JS399-19) on growth and morphology of four Fusarium sp. This fungicide targets the motor domain of type I myosin. Fusarium graminearum PH-1, Fusarium solani f. sp. pisi 77-13-4, Fusarium avenaceum IBT8464, and Fusarium avenaceum 05001, which has a K216Q amino-acid substitution at the resistance-implicated site in its myosin type I motor domain, were analyzed. Real-time imaging shows that JS399-19 inhibits fungal growth but not to the extent previously reported...
November 2016: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/27904109/transcatheter-embolization-of-high-flow-renal-arteriovenous-fistula-using-n-butyl-cyanoacrylate-accompanied-by-delayed-hydronephrosis
#2
Atsushi Mizuno, Yuka Morita, Sokun Fuwa, Hiroko Arioka, Yumi Harano, Koichiro Niwa, Yukihisa Saida
Renal arteriovenous fistula (AVF) is an uncommon anomaly characterized by the communication between renal arteries and veins. Renal AVFs are often asymptomatic but are occasionally accompanied by hematuria or heart failure. Transcatheter closure with embolization is a safe and effective treatment for renal AVF. We herein report an 87-year-old patient with heart failure due to renal AVF who was treated by transcatheter embolization. She developed bacteremia with hydronephrosis, which is a rare complication following the embolization of renal AVF...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27870875/a-novel-organ-culture-model-to-quantify-collagen-remodeling-in-tree-shrew-sclera
#3
Sarah Baldivia, Alexander Levy, Shylaja Hegde, Stijn J A Aper, Maarten Merkx, Rafael Grytz
Increasing evidence suggests that unknown collagen remodeling mechanisms in the sclera underlie myopia development. We are proposing a novel organ culture system in combination with two-photon fluorescence imaging to quantify collagen remodeling at the tissue- and lamella-level. Tree shrew scleral shells were cultured up to 7 days in serum-free media and cellular viability was investigated under: (i) minimal tissue manipulations; (ii) removal of intraocular tissues; gluing the eye to a washer using (iii) 50 μL and (iv) 200 μL of cyanoacrylate adhesive; (v) supplementing media with Ham's F-12 Nutrient Mixture; and (vi) culturing eyes subjected to 15 mmHg intraocular pressure in our new bioreactor...
2016: PloS One
https://www.readbyqxmd.com/read/27864616/randomized-clinical-trial-comparing-cyanoacrylate-glue-versus-suture-fixation-in-lichtenstein-hernia-repair-7-year-outcome-analysis
#4
M Matikainen, J Kössi, S Silvasti, T Hulmi, H Paajanen
BACKGROUND: Lichtenstein hernioplasty has relatively low recurrence rate, but chronic inguinal pain may cause harm to the patient. The aim of our study was to compare long-term results of cyanoacrylate glue versus absorbable sutures for mesh fixation in Lichtenstein hernioplasty. METHODS: Lichtenstein hernioplasty (n = 302) was performed under local anesthesia in three hospitals. The patients were randomized to receive either 1 ml of butyl-2-cyanoacrylate tissue glue (Glubran(®); 151 hernias) or absorbable polyglycolic acid sutures (Dexon(®); 151 hernias) for mesh fixation (Optilene(®) mesh)...
November 18, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27855336/targeting-distinct-myeloid-cell-populations-in%C3%A2-vivo-using-polymers-liposomes-and-microbubbles
#5
Can Ergen, Felix Heymann, Wa'el Al Rawashdeh, Felix Gremse, Matthias Bartneck, Ulf Panzer, Robert Pola, Michal Pechar, Gert Storm, Nicole Mohr, Matthias Barz, Rudolf Zentel, Fabian Kiessling, Christian Trautwein, Twan Lammers, Frank Tacke
Identifying intended or accidental cellular targets for drug delivery systems is highly relevant for evaluating therapeutic and toxic effects. However, limited knowledge exists on the distribution of nano- and micrometer-sized carrier systems at the cellular level in different organs. We hypothesized that clinically relevant carrier materials, differing in composition and size, are able to target distinct myeloid cell subsets that control inflammatory processes, such as macrophages, neutrophils, monocytes and dendritic cells...
November 9, 2016: Biomaterials
https://www.readbyqxmd.com/read/27847307/the-glue-that-holds-the-situation-together
#6
Kyle J Godfrey, Andrew R Harrison, Bobby S Korn, Don O Kikkawa
A 48-year-old man presented with a longstanding left upper eyelid mass that increased in size when bending forward. The mass was associated with enophthalmos and slowly increased in size with Valsalva maneuver. Magnetic resonance imaging and arteriography demonstrated a vascular malformation without an abnormal arterial component. Because of his increasing pain, the vascular malformation was excised in a multidisciplinary approach involving intraoperative fluoroscopic mapping, cyanoacrylate embolization and surgical excision...
November 12, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/27846779/effect-of-solvents-on-forming-poly-butyl-2-cyanoacrylate-encapsulated-paeonol-nanocapsules
#7
Jingjing Yao, Decheng Zeng, Yangxin Zhang, Dongdong Sun, Endong Yang, Haiping Liu, Feng Guo, Weiyun Wang
The effect of ethanol or acetone, as oil phase solvents, upon the form of paeonol-loaded poly(butyl-2-cyanoacrylate) encapsulated nanocapsules (Pae@PNCs) by interfacial spontaneously condensation were investigated. Pae@PNCs characterizations including morphology, radius distribution, polydispersity index (PDI), particle size, zeta potential, entrapment efficiency (EE%), drug loading (DL%) and in-vitro paeonol release kinetics were evaluated. Results show that 100% acetone have a significant effect on forming nanocapsules, which showed the smaller size (168...
November 16, 2016: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/27843488/dft-and-td-dft-calculation-of-new-thienopyrazine-based-small-molecules-for-organic-solar-cells
#8
Mohamed Bourass, Adil Touimi Benjelloun, Mohammed Benzakour, Mohammed Mcharfi, Mohammed Hamidi, Si Mohamed Bouzzine, Mohammed Bouachrine
BACKGROUND: Novel six organic donor-π-acceptor molecules (D-π-A) used for Bulk Heterojunction organic solar cells (BHJ), based on thienopyrazine were studied by density functional theory (DFT) and time-dependent DFT (TD-DFT) approaches, to shed light on how the π-conjugation order influence the performance of the solar cells. The electron acceptor group was 2-cyanoacrylic for all compounds, whereas the electron donor unit was varied and the influence was investigated. METHODS: The TD-DFT method, combined with a hybrid exchange-correlation functional using the Coulomb-attenuating method (CAM-B3LYP) in conjunction with a polarizable continuum model of salvation (PCM) together with a 6-31G(d,p) basis set, was used to predict the excitation energies, the absorption and the emission spectra of all molecules...
2016: Chemistry Central Journal
https://www.readbyqxmd.com/read/27843220/cyanoacrylate-injection-in-management-of-recurrent-vesicovaginal-fistula-our-experience
#9
Ajit S Sawant, Gaurav Vinod Kasat, Vikash Kumar
Treating recurrent vesicovaginal fistula (VVF) is a major clinical problem. We present a technique and special precautions taken during treatment of a small recurrent VVF with the help of combined cystoscopic and/or transvaginal injection of cyanoacrylate in two patients. Except for frequency of micturition in the first patient, postoperative follow-up was uneventful. Endoscopic management with cyanoacrylate is a simple and effective alternative to major reconstructive surgery.
October 2016: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/27842930/the-effect-of-poly-ethylene-glycol-coating-and-monomer-type-on-poly-alkyl-cyanoacrylate-nanoparticle-interactions-with-lipid-monolayers-and-cells
#10
Habib Baghirov, Sopio Melikishvili, Yrr Mørch, Einar Sulheim, Andreas K O Åslund, Tibor Hianik, Catharina de Lange Davies
The interaction of the promising drug carriers poly(alkyl cyanoacrylate) nanoparticles (PACA NPs) with lipid monolayers modeling the cell membrane and with RBE4 immortalized rat brain endothelial cells was compared to assess the relevance of lipid monolayer-based cell membrane models for PACA NP cellular uptake. NP properties such as size and charge of NPs and density of poly(ethylene glycol) coating (PEG) were kept in a narrow range to assess whether the type of PEG coating and the PACA monomer affected NP-monolayer and NP-cell interactions...
October 31, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27836404/randomized-controlled-trial-of-octyl-cyanoacrylate-skin-adhesive-versus-subcuticular-suture-for-skin-closure-after-implantable-venous-port-placement
#11
Jonathan G Martin, Scott T Hollenbeck, Gemini Janas, Ryan A Makar, Waleska M Pabon-Ramos, Paul V Suhocki, Michael J Miller, David R Sopko, Tony P Smith, Charles Y Kim
PURPOSE: To compare early outcomes of skin closure with octyl cyanoacrylate skin adhesive versus subcuticular suture closure. MATERIALS AND METHODS: Over a 7-month period, 109 subjects (28 men and 81 women; mean age, 58.6 y) scheduled to undergo single-lumen implantable venous port insertion for chemotherapy were randomly assigned to skin closure with either octyl cyanoacrylate skin adhesive or absorbable subcuticular suture after suturing the deep dermal layer...
November 8, 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27836205/effectiveness-of-cyanoacrylate-microbial-sealant-in-the-reduction-of-surgical-site-infection-in-gynecologic-oncology-procedures-a-phase-iii-single-institution-prospective-randomized-trial
#12
Eric D Thomas, Elizabeth K Nugent, Matthew C MacAllister, Katherine M Moxley, Lisa Landrum, Joan L Walker, D S McMeekin, Robert S Mannel, Gerald McGwin, Kathleen N Moore
OBJECTIVES: Surgery is a cornerstone for patients with gynecologic malignancies. Surgical site infections (SSI) remain a source of post-operative morbidity. Consequences range from escalated costs, delay in adjuvant therapy, and increased morbidity. Our primary objective was to evaluate the effectiveness of a cyanoacrylate microbial sealant (CMS) to reduce post-operative SSI following laparotomy for suspected gynecologic malignancy. METHODS: Patients were randomized using a 1:1 allocation to receive either standard skin preparation or standard preparation with CMS and stratified by BMI...
November 8, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27830860/efficient-organic-dyes-based-on-perpendicular-6-12-diphenyl-substituted-indolo-3-2-b-carbazole-donor
#13
Zhanhai Xiao, Yi Di, Zhifang Tan, Xudong Cheng, Bing Chen, Jiwen Feng
Three novel indolo[3,2-b]carbazole-based dyes have been designed and synthesized using a 6,12-diphenyl substituted indolo[3,2-b]carbazole core as a π-conjugated donor, a thiophene cyanoacrylic acid moiety as electron acceptor and anchoring group, together with triphenylamine, 3,4,5-trimethoxybenzene and bromine as a second donor group. The photophysical and electrochemical properties of the dyes have been investigated by UV spectroscopy and cyclic voltammetry (CV). Our study indicates that the second donor plays the important role of improving dye aggregation as well as tuning the photoelectronic properties...
November 30, 2016: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/27826768/the-fixation-on-fixation-ic-on-randomized-clinical-trial-comparing-cyanoacrylate-glue-versus-suture-fixation-in-lichtenstein-hernia-repair-7-year-outcome-analysis
#14
https://www.readbyqxmd.com/read/27826005/comparative-evaluation-of-polycyanoacrylates
#15
Yoav Barkan, Mira Levinman, Ilana Veprinsky-Zuzuliya, Tsadok Tsach, Emmanuelle Merqioul, Galia Blum, Abraham J Domb, Arijit Basu
: Cyanoacrylate esters (CA) and their corresponding polymers (PolyCA) are used as general and medical adhesives, biodegradable carriers for controlled drug delivery, and as agents for fingerprint development in forensic science. Most reports of cyanoacrylate are on ethyl or 2-octyl cyanoacrylate ester with little attention to other esters. It is the objective of this study to determine the differences amongst cyanoacrylate esters regarding their synthesis, chemical characterization, hydrolytic degradation, and thermal and mechanical properties...
November 4, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27815497/friction-blisters-on-the-hands-treated-successfully-using-2-octyl-cyanoacrylate-a-case-report
#16
Peter A Gearhart, Michael P Gaspar, Sidney M Jacoby
BACKGROUND: Friction blisters on the hand are challenging to treat as conventional dressings are prone to saturation, contamination, and loosening with active hand use and other mechanical stresses. Alternative methods and materials for dressing hand blisters warrant exploration. CASE SUMMARY: A 48-year-old male surgeon presented with friction blisters over his bilateral thumbs. The patient complained of significant difficulty in keeping his dressings clean and dry, significant pain with hand hygiene, and functional limitations at work...
November 4, 2016: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27812783/transcatheter-arterial-embolization-for-primary-postpartum-hemorrhage-predictive-factors-of-need-for-embolic-material-conversion-of-gelatin-sponge-particles-to-n-butyl-cyanoacrylate
#17
Yukichi Tanahashi, Satoshi Goshima, Hiroshi Kondo, Tomohiro Ando, Yoshifumi Noda, Hiroshi Kawada, Nobuyuki Kawai, Junichi Kotoku, Shigeru Furui, Masayuki Matsuo
PURPOSE: To identify predictive factors for embolic material conversion to N-butyl cyanoacrylate (NBCA) for the treatment of primary postpartum hemorrhage (PPH) after failed transcatheter arterial embolization (TAE) using gelatin sponge (GS). MATERIALS AND METHODS: Institutional review board approval was obtained. We retrospectively studied 62 consecutive women with primary PPH who underwent TAE between January 2006 and March 2015. Five of them were excluded for the following: cardiopulmonary arrest at arrival (n = 1), uterine inversion (n = 1), and hysterectomy after TAE (n = 3)...
November 3, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27803921/use-of-adipose-derived-stem-cells-to-support-topical-skin-adhesive-for-wound-closure-a-preliminary-report-from-animal-in-vivo-study
#18
Maciej Nowacki, Katarzyna Pietkun, Arkadiusz Jundziłł, Tomasz Kloskowski, Dariusz Grzanka, Joanna Skopinska-Wisniewska, Kinga Scibior, Maciej Gagat, Marta Pokrywczyńska, Alina Grzanka, Wojciech Zegarski, Rafał Czajkowski, Tomasz Drewa, Barbara Zegarska
The aim of this study was to determine the local and systemic effects of adipose-derived stem cells (ADSCs) as a component of topical skin adhesive in an animal artificial wound closure model. In presented study the cosmetic effects, histological analysis, mechanical properties, and cell migration have been assessed to evaluate the usefulness of ADSCs as supporting factor for octyl blend cyanoacrylate adhesive. The total of 40 rats were used and divided into six groups. In the Study Group, ADSCs were administered by multipoint injection of the six surrounding intrawound areas with additional freely leaving procedure of the cells between the skin flaps just before applying adhesive to close the wound...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27792823/novel-management-of-an-isolated-comminuted-cricoid-cartilage-fracture
#19
Aurora G Standlee, Derek J Rogers
Laryngeal trauma is a rare occurrence that can result in significant morbidity and mortality. Isolated cricoid cartilage fractures are exceedingly rare, and their treatment is highly variable. We describe a case of an isolated comminuted, uncalcified cricoid cartilage fracture in a 34-year-old man that responded well to novel management with suture and 2-octylcyanoacrylate tissue adhesive fixation intraoperatively and topical ciprofloxacin/dexamethasone applied to the airway postoperatively. We discuss the novel application of cyanoacrylate glue in laryngeal trauma and the potential benefits of topical ciprofloxacin/dexamethasone application to the airway...
October 2016: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/27789620/scalp-congenital-hemangioma-with-associated-high-output-cardiac-failure-in-a-premature-infant-case-report-and-review-of-literature
#20
Sumedh S Shah, Brian M Snelling, Samir Sur, Alexandra R Ramnath, Emmalee S Bandstra, Dileep R Yavagal
INTRODUCTION: Scalp congenital hemangiomas (CHs) are rare vascular malformations among infants; they can be associated with an array of complications, including cardiac and cosmetic issues. Here, we report the endovascular treatment of a premature infant with a suspected large right parietal scalp hemangioma and associated high-output cardiac failure. CASE DESCRIPTION: A two-day-old female premature infant (29 weeks gestational age; 1330 g birth weight) was referred by the neonatologists to our department for consultation and potential treatment of a large right parietal CH causing abrupt hypotension and high-output cardiac failure...
October 27, 2016: Interventional Neuroradiology
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