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https://www.readbyqxmd.com/read/29772622/-delay-in-high-grade-metastatic-prostate-cancer-progression-by-dutasteride-a-case-report
#1
Yuya Yamada, Hiroshi Fujiwara, Shinya Somiya, Shohei Fujikawa, Yuki Kamiyama, Masahiro Tamaki, Toshio Kanaoka
An 84-year-old man was referred to our hospital with swollen right cervical lymph nodes. Computed tomography showed right supraclavicular and mediastinal lymph node enlargement, and fluorodeoxyglucose positronemissiontomography showed multiple areas of abnormally increased radioactivity inthe right supraclavicular and mediastinal lymph nodes, right ninth rib, and left fifth and seventh ribs. Biopsy of the right supraclavicular lymph node revealed metastatic adenocarcinoma with partial immunohistochemical staining for prostate specific antigen (PSA)...
April 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29741162/the-urinary-sarcosine-creatinine-ratio-is-a-potential-diagnostic-and-prognostic-marker-in-prostate-cancer
#2
Meng Wang, Lihui Zou, Jing Liang, Xin Wang, Dalei Zhang, Yuan Fang, Junhua Zhang, Fei Xiao, Ming Liu
BACKGROUND The aim of this study was to evaluate the role of the urinary sarcosine/creatinine ratio in the diagnosis and prognosis of prostate cancer, using a sarcosine oxidase assay. MATERIAL AND METHODS Urine samples were obtained from 203 patients with benign prostate hyperplasia (BPH) and 209 patients with prostate cancer. Levels of urinary sarcosine were measured using the sarcosine oxidase method. The urinary sarcosine/creatinine ratios were compared between the group of patients with BPH and the patients with prostate cancer...
May 9, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29738184/-correlation-between-tcm-syndrome-types-and-clinical-symptoms-of-benign-prostatic-hyperplasia-with-chronic-prostatitis
#3
Xin-Fei Huang, Ke-Qin Ning, Qing Wang, Tao Liu, Ying He, Jian-Guo Xue, Li-Qin Dai, Yong-Kang Zhu
Objective: To investigate the correlation between the syndrome types of traditional Chinese medicine (TCM) and clinical symptoms of benign prostatic hyperplasia (BPH) with chronic prostatitis (BPH-CP). METHODS: We selected 150 cases of BPH-CP in this study and divided them into 7 TCM syndrome types. Using univariate and multivariate logistic regression analyses, we studied the correlation of each TCM syndrome type with the age, disease course, prostate volume, postvoid residual urine volume (PVR), prostate-specific antigen (PSA) level, maximum urinary flow rate (Qmax), and International Prostate Symptoms Score (IPSS)...
December 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29719325/incremental-value-of-68-gallium-prostate-specific-membrane-antigen-positron-emission-tomography-computed-tomography-in-patients-with-abnormal-prostate-specific-antigen-and-benign-transrectal-ultrasound-biopsy
#4
Manoj Gupta, Partha Sarathi Choudhury, Sudhir Rawal, Gurudutt Gupta
Introduction: Bladder outlet obstruction due to prostate enlargement is a common health problem in male and frequently investigated with prostate-specific antigen (PSA) and transrectal ultrasound (TRUS). TRUS-guided biopsy is critical to differentiate benign prostatic hyperplasia (BPH) or prostate cancer (PCa) even though it has been associated with false negative with reported 3%-16% incidence of PCa in BPH specimens. Prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT), a targeted molecular imaging for PCa, has showed promising results in recurrence and staging...
April 2018: Urology Annals
https://www.readbyqxmd.com/read/29695737/multi-lectin-affinity-chromatography-and-quantitative-proteomic-analysis-reveal-differential-glycoform-levels-between-prostate-cancer-and-benign-prostatic-hyperplasia-sera
#5
Sarah M Totten, Ravali Adusumilli, Majlinda Kullolli, Cheylene Tanimoto, James D Brooks, Parag Mallick, Sharon J Pitteri
Currently prostate-specific antigen is used for prostate cancer (PCa) screening, however it lacks the necessary specificity for differentiating PCa from other diseases of the prostate such as benign prostatic hyperplasia (BPH), presenting a clinical need to distinguish these cases at the molecular level. Protein glycosylation plays an important role in a number of cellular processes involved in neoplastic progression and is aberrant in PCa. In this study, we systematically interrogate the alterations in the circulating levels of hundreds of serum proteins and their glycoforms in PCa and BPH samples using multi-lectin affinity chromatography and quantitative mass spectrometry-based proteomics...
April 25, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29693288/limited-influence-of-dutasteride-on-individual-prostate-specific-antigen-variability-in-men-with-clinical-benign-prostatic-hyperplasia
#6
Hideki Takeshita, Satoru Kawakami, Makoto Kagawa, Akihiro Yano, Yohei Okada, Makoto Morozumi
No abstract text is available yet for this article.
April 25, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29674995/serum-steroid-ratio-profiles-in-prostate-cancer-a-new-diagnostic-tool-toward-a-personalized-medicine-approach
#7
Adriana Albini, Antonino Bruno, Barbara Bassani, Gioacchino D'Ambrosio, Giuseppe Pelosi, Paolo Consonni, Laura Castellani, Matteo Conti, Simone Cristoni, Douglas M Noonan
Background: Serum steroids are crucial molecules altered in prostate cancer (PCa). Mass spectrometry (MS) is currently the elected technology for the analysis of steroids in diverse biological samples. Steroids have complex biological pathways and stoichiometry and it is important to evaluate their quantitative ratio. MS applications to patient hormone profiling could lead to a diagnostic approach. Methods: Here, we employed the Surface Activated Chemical Ionization-Electrospray-NIST (SANIST) developed in our laboratories, to obtain quantitative serum steroid ratio relationship profiles with a machine learning Bayesian model to discriminate patients with PCa...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29672570/detection-of-glypican-1-gpc-1-expression-in-urine-cell-sediments-in-prostate-cancer
#8
Douglas H Campbell, Maria E Lund, Aline L Nocon, Paul J Cozzi, Mark Frydenberg, Paul De Souza, Belinda Schiller, Jennifer L Beebe-Dimmer, Julie J Ruterbusch, Bradley J Walsh
While measurement of serum prostate specific antigen (PSA) is an important screening tool for prostate cancer, new biomarkers are necessary for better discrimination between presence and absence of disease. The MIL-38 monoclonal antibody is specific for the membrane glycoprotein glypican 1 (GPC-1) and binds to prostate cancer tissue. Urine is known to be a source of cellular material. Thus, we hypothesized that detection of GPC-1 in urine cellular material may identify individuals with prostate cancer. Urine samples from patients with prostate cancer, benign prostatic hyperplasia (BPH), or normal controls were collected and cell sediments prepared...
2018: PloS One
https://www.readbyqxmd.com/read/29622903/prevalence-and-associated-factors-of-incidentally-diagnosed-prostatic-carcinoma-among-patients-who-had-transurethral-prostatectomy-in-tanzania-a-retrospective-study
#9
Daniel Gunda, Ibrahim Kido, Semvua Kilonzo, Igembe Nkandala, John Igenge, Bonaventura Mpondo
Background: Prostatic carcinoma carries a high morbidity and mortality if it is not diagnosed early. In resource limited countries, patients are at increased risk of being diagnosed late as they are operated for presumed benign prostatic hyperplasia. The information on the magnitude and risk factors of this problem in our setting could assist in the overall optimization of care of patients at risk. Methods: A retrospective study of patients who underwent prostatectomy for presumed benign prostatic enlargement was done at Bugando University Hspital in Tanzania...
January 2018: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29614511/tumor-derived-exosomal-long-noncoding-rnas-as-promising-diagnostic-biomarkers-for-prostate-cancer
#10
Yu-Hui Wang, Jia Ji, Bi-Cheng Wang, Hao Chen, Zhong-Hua Yang, Kun Wang, Chang-Liang Luo, Wu-Wen Zhang, Fu-Bing Wang, Xiao-Lian Zhang
BACKGROUND/AIMS: Exosomal circulating long non-coding RNAs (lncRNAs) in blood are emerging as clinically useful and non-invasive biomarkers for tumor diagnosis. However, normal cells can also secrete exosomes, so it is a prerequisite to obtain tumor-derived exosomes for better understanding of their diagnostic impacts in cancer. In this study, a dual-antibody-functionalized immunoaffinity system was established to isolate exosomes and investigate their lncRNAs expression pattern and clinical significance in prostate cancer (PCa)...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29608020/prostatic-stromal-inflammation-is-associated-with-bladder-outlet-obstruction-in-patients-with-benign-prostatic-hyperplasia
#11
So Inamura, Hideaki Ito, Tomochika Shinagawa, Manami Tsutsumiuchi, Minekatsu Taga, Motohiro Kobayashi, Osamu Yokoyama
BACKGROUND: Benign prostatic hyperplasia (BPH) is a common urologic disease in older men. Prostatic inflammation research has focused on the magnitude of inflammation; its location has received little attention. We investigated whether the anatomic location of prostatic inflammation is related to the severity of lower urinary tract symptoms (LUTS), measured subjectively and objectively. METHODS: We retrospectively analyzed hematoxylin+eosin-stained tissue specimens from 179 BPH patients who underwent transurethral resection of the prostate (TURP) or holmium laser enucleation of the prostate (HoLEP)...
April 2, 2018: Prostate
https://www.readbyqxmd.com/read/29603912/photoselective-vaporization-of-the-prostate-with-the-180-w-xps-greenlight-laser-five-year-experience-of-safety-efficiency-and-functional-outcomes
#12
Khaled Ajib, Mila Mansour, Marc Zanaty, Mansour Alnazari, Pierre-Alain Hueber, Malek Meskawi, Roger Valdivieso, Come Tholomier, Benjamin Pradere, Vincent Misrai, Dean Elterman, Kevin C Zorn
INTRODUCTION: Transurethral resection of the prostate (TURP) is still considered the gold standard surgical treatment for symptomatic benign prostatic hyperplasia (BPH). However, photoselective vaporization of the prostate (PVP) has gained widespread global acceptance in national guidelines as a safe and effective alternative option. Nevertheless, further evidence is required to assess the durability of Greenlight PVP. Herein, we reported our five years PVP experience with the Greenlight 180W XPS laser system...
March 19, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29581775/increased-paxillin-expression-in-prostate-cancer-is-associated-with-advanced-pathological-features-lymph-node-metastases-and-biochemical-recurrence
#13
Qing-Shui Zheng, Shao-Hao Chen, Yu-Peng Wu, Hui-Jun Chen, Hong Chen, Yong Wei, Xiao-Dong Li, Jin-Bei Huang, Xue-Yi Xue, Ning Xu
Purpose Paxillin regulates cell-cell adhesion, and altered Paxillin expression has been associated with human carcinogenesis. This study analyzed the association between Paxillin expression in prostate cancer (PCa) tissues with clinicopathological features, lymph node metastasis and biochemical PCa recurrence. Methods A total of 386 tissue specimens from PCa patients who received radical prostatectomy and 60 tissue specimens from benign prostatic hyperplasia (BPH) cases were collected to construct tissue microarrays, which were subsequently immunostained for Paxillin expression...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29580043/prostate-specific-antigen-mean-platelet-volume-and-platelet-distribution-width-in-combination-to-discriminate-prostate-cancer-from-benign-prostate-hyperplasia
#14
Shuang Fu, Xin Zhang, Ye Niu, Rui-Tao Wang
Background: Prostate cancer (PCa) represents the second most commonly diagnosed malignancy and the sixth leading cause for cancer related death among men worldwide. Although use of the prostate specific antigen (PSA) as a diagnostic marker has improved the detection and management of PCa, low specificity and sensitivity has limited its clinical efficacy. Moreover, elevated PSA is frequently observed in benign prostate hyperplasia (BPH). Mean platelet volume (MPV) and platelet distribution width (PDW) are commonly used indicators of platelet activation...
March 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29578193/interlink-between-cholesterol-cell-cycle-in-prostate-carcinoma
#15
Govind Singh, Shrimanjunath Sankanagoudar, Premnath Dogra, Nimai Chand Chandra
Background & objectives: Earlier reports have shown hypocholesterolaemia in cancer patients and high number of lipid rafts in cancer cells. The primary objective of this study was to compare the intracellular cholesterol turnover in non-cancerous (benign) prostatic hyperplasia (BPH) and carcinoma prostate (CAP) with normal prostate cells obtained from patients undergoing radical cystectomy for carcinoma bladder (sham control). Methods: ELISA-based estimation of prostate-specific antigen (PSA), evaluation of expression of low-density lipoprotein receptor (LDLR), peripheral-type benzodiazepine receptor (PBR) and cyclin E, immunohistochemistry and confocal microscopy, measurement of integrated optical density of the diaminobenzidine (DAB)-stained immunohistograms, isolation of nucleus and cell cytoplasm from prostate tissue by ultracentrifugation followed by estimation of cholesterol spectrophotometrically in isolated nuclear and cytoplasmic fractions were performed...
November 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29574327/clinical-significance-of-peripheral-blood-pca3-gene-expression-in-early-diagnosis-of-prostate-cancer
#16
Lin Chunhua, Haiwei Zhao, Huishan Zhao, Youyi Lu, Jitao Wu, Zhenli Gao, Guojun Li, Yulian Zhang, Ke Wang
Prostate cancer antigen 3 (PCA3) is one of the most promising genes currently investigated as a specific tumor biomarker for the diagnosis of prostate cancer. The purpose of this study was to investigate PCA3 gene expression in peripheral blood of prostate cancer (PCa) and benign prostate hyperplasia (BPH), and further to assess its clinical significance. We determined the copies of PCA3 mRNA in peripheral blood of PCa and BPH from 115 samples (PCa, n=78; BPH, n=37) using a quantitative reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) with TaqMan assay...
March 21, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29571584/using-genetic-and-epigenetic-markers-to-improve-differential-diagnosis-of-prostate-cancer-and-benign-prostatic-hyperplasia-by-noninvasive-methods-in-mexican-patients
#17
Beatriz E Sánchez, Adolfo Aguayo, Braulio Martínez, Fabiola Rodríguez, Melanie Marmolejo, Yevgeniya Svyryd, Leonora Luna, Luis A Muñoz, Miguel A Jiménez, Mariano Sotomayor, Florencia Vargas V, Osvaldo M Mutchinick
BACKGROUND: Prostate cancer (PCa) is the most common malignancy in Mexican men. Serum prostate-specific antigen (PSA) is the usual noninvasive biomarker used for its detection. Its low specificity can increase the number of unnecessary prostate biopsies and the incidence of unpleasant complications for patients. The androgen-receptor gene (AR-CAG) repeat length and the percentage of promoter methylation (PPM) of genes glutathione-S-transferase P1 (GSTP1) and Ras association domain family 1 isoform A (RASSF1A) improve PCa detection...
February 27, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29562494/aberrant-expression-of-mir-141-and-nuclear-receptor-small-heterodimer-partner-in-clinical-samples-of-prostate-cancer
#18
Maryam Khorasani, Ladan Teimoori-Toolabi, Taghi Naserpour Farivar, Mojgan Asgari, Maryam Abolhasani, Hossein Shahrokh, Ali Afkar, Elham Kalantari, Amir Peymani, Reza Mahdian
BACKGROUND: Prostate cancer (PCa) is the second most common cancer in men worldwide. Currently, prostate-specific antigen (PSA) test and digital rectal exam are the main screening tests used for PCa diagnosis. However, due to the low specificity of these tests, new alternative biomarkers such as deregulated RNAs and microRNAs have been implemented. OBJECTIVES: Aberrant expression of small heterodimer partner gene (SHP, NR0B2) and mir-141 are reported in various cancers...
February 28, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29556488/lipid-associated-antioxidants-arylesterase-and-paraoxonase-1-in-benign-prostatic-hyperplasia-treatment-na%C3%A3-ve-patients
#19
George Awuku Asare, Sabina Ekua Andam, Henry Asare-Anane, Seth Ammanquah, Yvonne Anang-Quartey, Daniel K Afriyie, Iddis Musah
Background: Oxidative stress and antioxidants have been implicated in many diseases including prostate cancer and benign prostatic hyperplasia (BPH). Lipid peroxidation contributes to oxidative stress. However, new and emerging antioxidants such as paraoxonase 1 (PON1) and arylesterase (ARE) associated with lipoprotein peroxidation have not been examined in BPH patients. PON1 and ARE, a high-density lipoprotein (HDL) cholesterol-bound enzyme system of antioxidants, protect low-density lipoprotein (LDL) cholesterol and HDL from oxidation by hydrolysis...
March 2018: Prostate International
https://www.readbyqxmd.com/read/29523809/factors-associated-with-prostate-specific-antigen-testing-in-australians-analysis-of-the-new-south-wales-45-and-up-study
#20
Visalini Nair-Shalliker, Albert Bang, Marianne Weber, David E Goldsbury, Michael Caruana, Jon Emery, Emily Banks, Karen Canfell, Dianne L O'Connell, David P Smith
Australia has one of the highest incidence rates of prostate cancer (PC) worldwide, due in part to widespread prostate specific antigen (PSA) testing. We aimed to identify factors associated with PSA testing in Australian men without a diagnosis of prostate cancer or prior prostate disease. Participants were men joining the 45 and Up Study in 2006-2009, aged ≥45 years at recruitment. Self-completed questionnaires were linked to cancer registrations, hospitalisations, health services data and deaths. Men with a history of PC, radical prostatectomy or a "monitoring" PSA test for prostate disease were excluded...
March 9, 2018: Scientific Reports
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