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Prostate specific antigen, bph

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https://www.readbyqxmd.com/read/27896579/prostatic-artery-embolization-in-treating-benign-prostatic-hyperplasia-a-systematic-review
#1
Jeremy Y C Teoh, Peter K F Chiu, Chi-Hang Yee, Hon-Ming Wong, Chi-Kwok Chan, Eddie S Y Chan, Simon S M Hou, Chi-Fai Ng
INTRODUCTION: We systemically reviewed the current evidence on prostatic artery embolization (PAE) in treating men with benign prostatic hyperplasia. METHODS: A systemic literature search was conducted in PubMed, EMBASE and Web of Science on 1 May 2016 without time constraints. Outcomes of interest included the changes in the International Prostate Symptom Score (IPSS), quality-of-life (QOL) score, peak urinary flow (Qmax), post-void residual urine (PVR), International Index of Erectile Function (IIEF) score, prostate volume (PV) and prostate-specific antigen (PSA) level...
November 28, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27880726/chrysophanic-acid-reduces-testosterone-induced-benign-prostatic-hyperplasia-in-rats-by-suppressing-5%C3%AE-reductase-and-extracellular-signal-regulated-kinase
#2
Dong-Hyun Youn, Jinbong Park, Hye-Lin Kim, Yunu Jung, JongWook Kang, Mi-Young Jeong, Gautam Sethi, Kwang Seok Ahn, Jae-Young Um
Benign prostatic hyperplasia (BPH) is one of the most common chronic diseases in male population, of which incidence increases gradually with age. In this study, we investigated the effect of chrysophanic acid (CA) on BPH. BPH was induced by a 4-week injection of testosterone propionate (TP). Four weeks of further injection with vehicle, TP, TP + CA, TP + finasteride was carried on. In the CA treatment group, the prostate weight was reduced and the TP-induced histological changes were restored as the normal control group...
November 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/27863699/systematic-review-and-meta-analysis-of-prostatic-artery-embolisation-for-lower-urinary-tract-symptoms-related-to-benign-prostatic-hyperplasia
#3
J-S Pyo, W J Cho
AIM: To evaluate the efficacy of prostatic artery embolisation (PAE) in lower urinary tract symptoms (LUTS) related to benign prostatic hyperplasia (BPH) at short- and mid-term follow-up. MATERIALS AND METHODS: The current study included 484 BPH patients from seven eligible studies. A meta-analysis was performed to determine the mean differences in parameters associated with LUTS, including the international prostate symptom score (IPSS), peak urinary flow (Qmax), post-void residual volume (PVR), quality of life score (QoL), prostate-specific antigen level (PSA), and prostatic volume (PV), between baseline and follow-up periods...
November 15, 2016: Clinical Radiology
https://www.readbyqxmd.com/read/27842896/kinesin-family-member-11-mrna-expression-predicts-prostate-cancer-aggressiveness
#4
Xuan-Mei Piao, Young Joon Byun, Pildu Jeong, Yun-Sok Ha, Eun Sang Yoo, Seok Joong Yun, Wun-Jae Kim
BACKGROUND: KIF11 (kinesin family member 11), a molecular motor protein, is essential to mitosis and cell cycle progression. Inhibitors of KIF11 have been developed as chemotherapeutic agents for the treatment of various cancers. Regarding prostate cancer (PCa), clinical trials using KIF11 inhibitors for the treatment of castration-resistant PCa have been initiated. We hypothesized that a relationship might exist between KIF11 expression and PCa. To investigate the functional activities and clinical usefulness of KIF11 in PCa, we used quantitative real-time reverse transcriptase polymerase chain reaction to monitor the KIF11 expression patterns...
October 19, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27826135/pim-3-is-a-critical-risk-factor-in-development-and-prognosis-of-prostate-cancer
#5
Yanchun Qu, Changwen Zhang, E Du, Andi Wang, Yuming Yang, Jianing Guo, Aixiang Wang, Zhihong Zhang, Yong Xu
BACKGROUND Pim-3 kinase is a highly homologous serine/threonine kinase that is overexpressed in hematological malignancies and solid tumors. Few studies have been conducted to define the role of Pim-3 in solid tumors, especially in prostate cancer. The aim of this study was to define the role of Pim-3 in development and prognosis of prostate cancer. MATERIAL AND METHODS We collected specimens from 160 patients with prostate cancer, as well as 100 patients with benign prostatic hyperplasia. Realtime polymerase chain reaction was used for the assessment of Pim-3 expression at the RNA level and Western blot was used to quantify the Pim-3 protein synthesis in 3 different cell lines...
November 9, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27813361/high-serum-dihydrotestosterone-examined-by-ultrasensitive-lc-ms-ms-as-a-predictor-of-benign-prostatic-hyperplasia-or-gleason-score-6-cancer-in-men-with-prostate-specific-antigen-levels-of-3-10%C3%A2-ng-ml
#6
Y Miyoshi, H Uemura, K Suzuki, Y Shibata, S Honma, M Harada, Y Kubota
There has been no consensus on the role of serum androgen concentrations in prostate cancer detection in men with prostate-specific antigen levels of 3-10 ng/mL. In this study, testosterone and dihydrotestosterone concentrations in blood were examined by a newly developed method using ultrasensitive liquid chromatography with two serially linked mass spectrometers (LC-MS/MS). We investigated the correlation between serum androgen levels and Gleason scores at biopsy. We analyzed data of 157 men with a total prostate-specific antigen range of 3-10 ng/mL who underwent initial systematic prostate needle biopsy for suspected prostate cancer between April 2000 and July 2003...
November 3, 2016: Andrology
https://www.readbyqxmd.com/read/27774780/understanding-patient-and-physician-perceptions-of-benign-prostatic-hyperplasia-in-asia-pacific-latin-america-and-the-commonwealth-of-independent-states-the-prostate-research-on-behaviour-and-education-probe-ii-survey
#7
Phillip Ertel, Burkay Adalig, Ipek Demircan, Belinda Lartey, Michael J Manyak
AIM: To assess attitudes and beliefs towards benign prostatic hyperplasia (BPH)/ lower urinary tract symptoms (LUTS) and its treatment among patients and physicians in Latin America, Asia Pacific and the Commonwealth of Independent States (CIS). METHODS: Cross-sectional, quantitative study conducted between December 2014 and September 2015. Separate questionnaires were administered to BPH/LUTS patients receiving drug treatment for their condition and to practising physicians who treat patients with BPH/LUTS...
October 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/27749139/proportion-and-characteristics-of-men-with-unknown-risk-category-in-the-national-prostate-cancer-register-of-sweden
#8
Katarina Tomic, Marcus Westerberg, David Robinson, Hans Garmo, Pär Stattin
BACKGROUND: Knowledge on missing data in a clinical cancer register is important to assess the validity of research results. For analysis of prostate cancer (Pca), risk category, a composite variable based on serum levels of prostate specific antigen (PSA), stage, and Gleason score, is crucial for treatment decisions and a strong determinant of outcome. The aim of this study was to assess the proportion and characteristics of men in the National Prostate Cancer Register (NPCR) of Sweden with unknown risk category...
December 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27742235/meta-analysis-of-prostatic-artery-embolization-for-benign-prostatic-hyperplasia
#9
Andre Uflacker, Ziv J Haskal, Tiago Bilhim, James Patrie, Timothy Huber, João Martins Pisco
PURPOSE: To perform meta-analysis of available data on prostatic artery embolization (PAE). MATERIALS AND METHODS: Meta-analysis was conducted on articles published between November 2009 and December 2015. Peer-reviewed studies with > 5 patients and standard deviations and/or individual-level data on one or more of the following outcomes were included: prostate volume (PV), peak flow rate (Qmax), postvoid residual (PVR), International Prostate Symptom Score (IPSS), quality of life (QOL) score, International Index of Erectile Function (IIEF) score, and prostate-specific antigen (PSA) level...
October 11, 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27734427/epca2-22-a-silver-lining-for-early-diagnosis-of-prostate-cancer
#10
Gholamreza Pourmand, Majid Safavi, Ayat Ahmadi, Elaheh Houdeh, Mohammad Noori, Rahil Mashhadi, Farimah Alizadeh, Elaheh Salimi, Fariba Heydari, Abdolrasoul Mehrsai, Naghmeh Pourmand
PURPOSE: To investigate whether EPCA-2 (a prostate matrix nuclear protein) can be a more helpful marker in prostate cancer diagnosis. MATERIALS AND METHODS: 176 patients enrolled in this study had abnormal prostate specific antigen (PSA) or digital rectal examination and were candidates for prostate needle biopsy. Blood samples were obtained from each patient prior to biopsy and the samples were frozen for EPCA-2 measurement. Patients diagnosed with cancer were assigned to the case group and those with benign prostate hyperplasia (BPH) were included in the control group...
October 10, 2016: Urology Journal
https://www.readbyqxmd.com/read/27733065/photoselective-vaporization-of-the-prostate-long-term-outcomes-and-safety-during-10-years-of-follow-up
#11
Yasushi Yamada, Jun Furusawa, Yoshiki Sugimura, Isao Kuromatsu
PURPOSE: To evaluate the long-term outcomes and safety photoselective vaporization of the prostate (PVP). PATIENTS AND METHODS: From April 2005 to December 2015, a total of 1154 patients with benign prostatic hyperplasia underwent PVP. The type of Green Light laser was an 80 W potassium-titanyl-phosphate laser and later a 120 W lithium triborate laser. Before and after surgery, the International Prostate Symptom Score (IPSS), maximum urinary flow rate (Qmax), post-voiding volume of residual urine (PVR), prostate-specific antigen (PSA) level, and prostate volume were assessed regularly...
December 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27706591/polymorphisms-of-enos-catalase-and-myeloperoxidase-genes-in-prostate-cancer-in-turkish-men-preliminary-results
#12
G G Ceylan, C Ceylan, B Gülmemmedov, Ş Tonyalı, O Odabaş, A Gözalan, I Keleş, E Öztürk
Prostate cancer (PCa) is the most common type of neoplasm in European males. Genetic and epigenetic factors contribute to PCa development and progression. In this study, we aimed to assess the relationship between PCa and polymorphisms in the genes encoding endothelial nitric oxide synthase (eNOS), catalase (CAT), and myeloperoxidase (MPO). In total, 193 patients were included in the study. Patients were divided into three groups: PCa (78), benign prostate hyperplasia (40), and control males (75). The parameters assessed included body mass index (BMI), smoking habits, presence of prostatism, prostate-specific antigen (PSA) levels, Gleason scores of prostate specimens, as well as polymorphisms in eNOS-G894T, CAT- 262T, and MPO G-463T genes...
August 19, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27696472/comparative-analysis-of-prostate-specific-antigen-psa-by-two-dimensional-gel-electrophoresis-and-capillary-electrophoresis
#13
Sílvia Barrabés, Noemi Farina-Gomez, Esther Llop, Angel Puerta, Jose Carlos Diez-Masa, Antoinette Perry, Rafael de Llorens, Mercedes de Frutos, Rosa Peracaula
Serum levels of Prostate Specific Antigen (PSA) are not fully specific for prostate cancer (PCa) diagnosis and several efforts are focused on searching to improve PCa markers through the study of PSA subforms that could be cancer associated. We have previously reported by 2DE a decrease in the sialic acid content of PSA from PCa compared to BPH patients based on the different proportion of the PSA spots. However, faster and more quantitative techniques, easier to automate than 2-DE, are desirable. In this study we examined the potential of CE for resolving PSA subforms in different samples and compared the results with those obtained by 2DE...
October 2, 2016: Electrophoresis
https://www.readbyqxmd.com/read/27660027/detection-of-trichomonas-vaginalis-in-prostate-tissue-and-serostatus-in-patients-with-asymptomatic-benign-prostatic-hyperplasia
#14
Jamshaid Iqbal, Jumanah Al-Rashed, Elijah O Kehinde
BACKGROUND: Despite a worldwide common and progressive nature of benign prostate hyperplasia (BPH) in older men, no association has been observed between a causative pathogen and other etiology so far. METHODS: In this study, we investigated a causative association of Trichomonas vaginalis, a flagellate protozoan parasite, in 171 BPH cases presenting without symptoms of prostatitis at a surgical outpatient clinic in Kuwait. We detected T. vaginalis DNA by polymerase chain reaction (PCR) and T...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27647472/evidence-based-hmo-care-for-prostate-specific-antigen-testing
#15
Daniel J Merenstein, Frank J D'Amico, Shlomo Vinker, Stephen Petterson, Amnon Lahad
BACKGROUND: There is pressure in the U.S. system to move away from fee-for-service models to a more pre-paid system, which may result in decreased costs, but the impact on evidence-based care is unclear. We examined a large pre-paid Health Maintenance Organizations (HMO) in Israel to see if evidence-based guidelines are followed for prostate specific antigen (PSA) testing. METHODS: A retrospective cohort of ambulatory visits from 2002 to 2011 of patients age >75 receiving care from Clalit Health Services was conducted...
September 20, 2016: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/27599375/effect-of-kolaviron-a-biflavanoid-complex-from-garcinia-kola-on-some-biochemical-parameters-in-experimentally-induced-benign-prostatic-hyperplasic-rats
#16
W O Kalu, P N Okafor, I I Ijeh, C Eleazu
BACKGROUND: To determine the effect of kolaviron on some biochemical parameters in benign prostatic hyperplasia (BPH) rats. METHODS: BPH was induced in rats using a mixture of dihydrotestosterone and estradiol valerate (10:1). RESULTS: The lethal dose of kolaviron was 3050mg/kg body weight. Body weights, relative heart weight (RHW), relative liver weight (RLW), serum levels of prostate specific antigen, prolactin, estradiol, testosterone, testosterone/estradiol ratio, aspartate transaminase (AST), alanine transaminase (ALT), urea, creatinine and prostatic levels of total proteins in the normal rats administered finasteride (standard drug) or kolaviron were not different (P>0...
September 3, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27598335/urinary-polyamines-a-pilot-study-on-their-roles-as-prostate-cancer-detection-biomarkers
#17
Tik-Hung Tsoi, Chi-Fai Chan, Wai-Lun Chan, Ka-Fung Chiu, Wing-Tak Wong, Chi-Fai Ng, Ka-Leung Wong
Current screening methods towards prostate cancer (PCa) are not without limitations. Research work has been on-going to assess if there are other better tests suitable for primary or secondary screening of PCa to supplement the serum prostate specific antigen (PSA) test, which fails to work accurately in a grey zone of 4-10ng/ml. In this pilot study, the potential roles of urinary polyamines as prostate cancer biomarkers were evaluated. PCa, benign prostatic hyperplasia (BPH) patients and healthy controls (HC) showing PSA>4...
2016: PloS One
https://www.readbyqxmd.com/read/27592008/efficacy-and-safety-of-prostatic-arterial-embolization-systematic-review-with-meta-analysis-and-meta-regression
#18
Sung Ryul Shim, Karan Kanhai, Young Myoung Ko, Jae Heon Kim
PURPOSE: This study attempted to overcome the limitations of previous systematic reviews and to demonstrate the overall treatment efficacy and safety of prostatic arterial embolization (PAE) compared with standard therapy. MATERIALS AND METHODS: Meta-analyses were done for both RCTs and single-group trials. Meta-regression analysis for the moderator effect was performed with single-group analysis. Outcomes measured were mean changes in IPSS, quality of life, maximal urinary flow rate, prostate volume, post-voided residual volume, and prostate specific antigen levels...
August 31, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27564286/bipolar-transurethral-enucleation-and-resection-of-the-prostate-versus-bipolar-resection-of-the-prostate-for-prostates-larger-than-60gr-a-retrospective-study-at-a-single-academic-tertiary-care-center
#19
Yong Wei, Ning Xu, Shao-Hao Chen, Xiao-Dong Li, Qing-Shui Zheng, Yun-Zhi Lin, Xue-Yi Xue
OBJECTIVE: To evaluate the efficacy and safety of bipolar transurethral enucleation and resection of the prostate (B-TUERP) versus bipolar transurethral resection of the prostate (B-TURP) in the treatment of prostates larger than 60g. MATERIAL AND METHODS: Clinical data for 270 BPH patients who underwent B-TUERP and 204 patients who underwent B-TURP for BPH from May 2007 to May 2013 at our center were retrospectively analyzed. Outcome measures included operative time, decreased hemoglobin level, total prostate specific antigen (TPSA), International Prostate Symptom Score (IPSS), maximal urinary flow rate (Qmax), quality of life (QoL) score, post void residual urine volume (RUV), bladder irrigation duration, hospital stay, and the weight of resected prostatic tissue...
July 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27564285/predictive-risk-factors-of-postoperative-urinary-incontinence-following-holmium-laser-enucleation-of-the-prostate-during-the-initial-learning-period
#20
Shuichiro Kobayashi, Masataka Yano, Takayuki Nakayama, Satoshi Kitahara
PURPOSE: To determine the predictive factors for postoperative urinary incontinence (UI) following holmium laser enucleation of the prostate (HoLEP) during the initial learning period. PATIENTS AND METHODS: We evaluated 127 patients with benign prostatic hyperplasia who underwent HoLEP between January 2011 and December 2013. We recorded clinical variables, including blood loss, serum prostate-specific antigen levels, and the presence or absence of UI. Blood loss was estimated as a decline in postoperative hemoglobina levels...
July 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
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