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https://www.readbyqxmd.com/read/27918991/sample-preparation-of-serum-to-allow-capillary-electrophoresis-analysis-of-prostate-specific-antigen-isoforms
#1
Noemi Farina-Gomez, Silvia Barrabes, Jorge E Gomez-Lopez, Monica Gonzalez, Angel Puerta, Diana Navarro-Calderon, Eduardo Albers-Acosta, Carlos Olivier, Jose C Diez-Masa, Rosa Peracaula, Mercedes de Frutos
Prostate cancer is the second most frequently diagnosed cancer in men worldwide. Currently prostate specific antigen (PSA) serum concentration is the most used prostate cancer marker, but it only shows limited specificity. Because PSA glycosylation is altered by prostate cancer, detecting glycosylation changes could increase PSA specificity as a prostate cancer marker. Changes in PSA glycosylation can modify its electrophoretic- behavior and techniques such as capillary zone electrophoresis (CZE) and two-dimensional electrophoresis (2-DE) could be applied to detect changes in PSA glycosylation...
November 24, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27915474/racial-differences-in-the-diagnosis-and-treatment-of-prostate-cancer
#2
REVIEW
Giuliano Di Pietro, Ganna Chornokur, Nagi B Kumar, Chemar Davis, Jong Y Park
Disparities between African American and Caucasian men in prostate cancer (PCa) diagnosis and treatment in the United States have been well established, with significant racial disparities documented at all stages of PCa management, from differences in the type of treatment offered to progression-free survival or death. These disparities appear to be complex in nature, involving biological determinants as well as socioeconomic and cultural aspects. We present a review of the literature on racial disparities in the diagnosis of PCa, treatment, survival, and genetic susceptibility...
November 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27914715/prostate-cancer-in-young-adults-seventeen-year-clinical-experience-of-a-single-center
#3
Tzu-Hao Huang, Junne-Yih Kuo, Yi-Hsiu Huang, Hsiao-Jen Chung, William J S Huang, Howard H H Wu, Yen-Hwa Chang, Alex T L Lin, Kuang-Kuo Chen
BACKGROUND: In the general population, prostate adenocarcinoma affects predominately older men. If fact, most current guidelines suggest that males over the age of 50 years should undergo prostate cancer screening. However, the clinical behavior and prognosis of prostate cancer in young adults is not well defined. The aim of this study was to evaluate the clinical behavior, pathological characteristics, and prognosis of prostate cancer in young adults. METHODS: We retrospectively reviewed the records of young patients (age, ≤50 years) in our hospital with prostate adenocarcinoma between 1997 and 2013...
November 30, 2016: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/27910728/predictive-factors-associated-with-biochemical-recurrence-following-radical-prostatectomy-for-pathological-t2-prostate-cancer-with-negative-surgical-margins
#4
Fouad Aoun, Simone Albisinni, Benjamin Henriet, Bertrand Tombal, Roland Van Velthoven, Thierry Roumeguère
OBJECTIVE: The aim of this study was to determine factors associated with the development of biochemical recurrence (BCR) following radical prostatectomy in patients with pathological T2 prostate cancer and negative surgical margins. MATERIALS AND METHODS: This retrospective multicentre cohort study included 1252 consecutive patients with pT2 pN0/Nx and negative surgical margins on radical prostatectomy and without any adjuvant treatment, performed in three Belgian centres...
December 2, 2016: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/27910461/a-novel-microgripper-hybrid-driven-by-a-piezoelectric-stack-actuator-and-piezoelectric-cantilever-actuators
#5
Weilin Chen, Xianmin Zhang, Sergej Fatikow
For the piezo-driven microgripper, one issue is to enlarge the grasping stroke and realize parallel grasping movement in the compact design. Piezoelectric stack actuator (PSA) and piezoelectric cantilever actuator (PCA) are two kinds of typical piezoelectric actuators. In this study, a novel microgripper hybrid driven by a PSA and two PCAs is proposed, which can be a better solution for the issue, compared with the previous microgripper using PSA-driven multi-stages displacement amplification mechanism (DAM) or using longer and narrower PCAs...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27909617/diagnostic-value-of-micrornas-in-prostate-cancer-patients-with-prostate-specific-antigen-psa-levels-between-2-and-10-ng-ml
#6
Serin Akbayır, Necati Muşlu, Sema Erden, Murat Bozlu
OBJECTIVE: Prostate specific antigen (PSA), used for the early diagnosis of prostate cancer (PCa), is one of the best tumour markers known so far. However, in situations when PSA is between 2-10 ng/mL, which is named as grey zone, PSA falls short of distinguishing benign prostate diseases from PCa. On the other hand, it was demonstrated in many previous studies that microRNA (miRNA) could be a marker for cancer. Therefore, in this study, it was aimed to enhance the diagnostic power of PSA, especially with grey zone patients, by the use of miRNA...
December 2016: Turkish Journal of Urology
https://www.readbyqxmd.com/read/27906997/role-of-genetic-polymorphisms-in-the-development-and-prognosis-of-sporadic-and-familial-prostate-cancer
#7
Sabrina T Reis, Nayara I Viana, Katia R M Leite, Erico Diogenes, Alberto A Antunes, Alexandre Iscaife, Adriano J Nesrallah, Carlo C Passerotti, Victor Srougi, José Pontes-Junior, Mary Ellen Salles, William C Nahas, Miguel Srougi
BACKGROUNDS: Our aim was to evaluate the role of 20 genetic polymorphisms in the development and prognosis of sporadic and familial PC. A case-control study of 185 patients who underwent radical prostatectomy from 1997 to 2011. These patients were divided into two groups based on their family history. Gleason grade, PSA value and pathological TNM 2002 stage were used as prognostic factors. Blood samples from 70 men without PC were used as controls. The SNPs were genotyped using a TaqMan® SNP Genotyping Assay Kit...
2016: PloS One
https://www.readbyqxmd.com/read/27904688/molecular-mechanism-of-prostate-cancer-cell-apoptosis-induced-by-busulfan-via-adjustment-of-androgen-receptor-phosphatization
#8
Jun Liu, Guojun Jiang, Aiping Yang, Guohui Yang, Wenjuan Yang, Yi Fang
OBJECTIVE: To probe killing effect of busulfan to prostate cancer cell without androgen and the influence of androgen receptor phosphatization and analyze its molecular mechanism. METHODS: prostate cancer cell line 22RV1, LAPC4 and LNCaP treated with busulfan under androgen-free condition underwent CCK-8 examination to probe killing ability of the medicine. Flow cytometry was used to check the influence of busulfan on apoptosis rate of prostate cancer cell line LAPC4...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27883257/determining-the-binding-affinities-of-prostate-specific-antigen-to-lectins-spr-and-microarray-approaches
#9
Pavel Damborský, Martina Zámorová, Jaroslav Katrlík
Prostate cancer (PCa) is one of the most common newly diagnosed cancer among men and we focused on its traditional biomarker, prostate-specific antigen (PSA), using targeted glycomics-based strategies. The aberrant glycosylation pattern of PSA may serve as valuable tool for improving PCa diagnosis including its early-stage. In the present work we evaluated the usability of two techniques, surface plasmon resonance and protein microarray assay, for the study and characterization of interactions of PSA (both free and complexed) with 6 lectins (SNA, ConA, RCA, AAL, WGA and MAA II)...
November 24, 2016: Proteomics
https://www.readbyqxmd.com/read/27882806/comorbidity-as-a-predictor-of-overall-survival-in-prostate-cancer-patients-treated-with-external-beam-radiotherapy-combined-with-hdr-brachytherapy-boosts
#10
Marie Hjälm-Eriksson, Anders Ullén, Hemming Johansson, Seymoure Levitt, Sten Nilsson, Karl-Mikael Kälkner
BACKGROUND: The risk stratification currently applied prior to curative treatment for localized prostate cancer (PC) does not take into account comorbidity or age. Therefore, we investigated the impact of comorbidity on overall survival (OS) in PC patients treated with external beam radiotherapy (EBRT) and high-dose rate (HDR) brachytherapy boost. MATERIAL AND METHODS: At a single center, 611 consecutive patients diagnosed with localized PC from 1998 to 2004 underwent definitive EBRT (50 Gy) and HDR brachytherapy boosts (2 × 10 Gy) combined with neoadjuvant total androgen blockade...
November 24, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27867812/comparisons-of-oncological-and-functional-outcomes-among-radical-retropubic-prostatectomy-high-dose-rate-brachytherapy-cryoablation-and-high-intensity-focused-ultrasound-for-localized-prostate-cancer
#11
Po Hui Chiang, Yi Yang Liu
PURPOSE: To conduct a retrospective, single institutional and comparative study for radical retropubic prostatectomy (RRP), high dose rate brachytherapy (HDRBT), cryoablation and high-intensity focused ultrasound (HIFU) in localized prostate cancer with respect to oncological and functional outcomes. METHODS: We reviewed 97, 161, 114 and 120 patients of RRP, HDRBT, cryoablation and HIFU respectively for localized prostate cancer from May 2008 to December 2013. PSA biochemical recurrence, salvage treatment-free rate, metastasis-free rate, and biochemical recurrence-free survival were analyzed for oncological outcomes...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27863963/the-dose-response-of-salvage-radiotherapy-following-radical-prostatectomy-a-systematic-review-and-meta-analysis
#12
Christopher R King
PURPOSE/OBJECTIVES: To date neither the optimal radiotherapy dose nor the existence of a dose-response has been established for salvage RT (SRT). MATERIALS/METHODS: A systematic review from 1996 to 2015 and meta-analysis was performed to identify the pathologic, clinical and treatment factors associated with relapse-free survival (RFS) after SRT (uniformly defined as a PSA>0.2ng/mL or rising above post-SRT nadir). A sigmoidal dose-response curve was objectively fitted and a non-parametric statistical test used to determine significance...
November 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27863438/immunohistochemical-staining-of-erg-and-sox9-as-potential-biomarkers-of-docetaxel-response-in-patients-with-metastatic-castration-resistant-prostate-cancer
#13
Wan Song, Ghee Young Kwon, Jeong Hoon Kim, Joung Eun Lim, Hwang Gyun Jeon, Seong Il Seo, Seong Soo Jeon, Han Yong Choi, Byong Chang Jeong, Hyun Moo Lee
We aimed to evaluate ERG and SOX9 as potential biomarkers of docetaxel response in metastatic castration-resistant prostate cancer (mCRPC) patients. Seventy-one mCRPC patients were evaluated. Tissue microarrays were constructed and immunohistochemistry was performed. Treatment response was assessed by prostate specific antigen (PSA) response rate, PSA progression-free survival (PSA-PFS), clinical/radiologic PFS (C/R-PFS) and overall survival (OS). ERG and SOX9 were found in 13 (18.3%) and 62 (87.3%) patients, respectively...
November 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27862863/value-of-111-in-psma-radioguided-surgery-for-salvage-lymphadenectomy-in-recurrent-prostate-cancer-correlation-with-histopathology-and-clinical-follow-up
#14
Isabel Rauscher, Charlotte Düwel, Martina Wirtz, Margret Schottelius, Hans-Jürgen Wester, Kristina Schwamborn, Bernhard Haller, Markus Schwaiger, Jürgen E Gschwend, Matthias Eiber, Tobias Maurer
OBJECTIVES: To evaluate the use of (111) In-labeled PSMA-I&T based radioguided surgery ((111) In-PSMA-RGS) for salvage surgery in recurrent prostate cancer (PC) using comparison of intraoperative γ-probe measurements to histopathological results of dissected specimens. Furthermore, the success of (111) In-PSMA-RGS was determined by postoperative prostate-specific antigen (PSA) responses, PC-specific treatment-free survival as well as postoperative complication rates. PATIENTS AND METHODS: In this study, 31 consecutive patients with localized recurrent PC undergoing salvage surgery with PSMA-targeted RGS using an (111) In-labeled PSMA ligand were retrospectively included from April 2014 to July 2015...
November 10, 2016: BJU International
https://www.readbyqxmd.com/read/27862097/phase-ib-trial-of-cabazitaxel-and-tasquinimod-in-men-with-heavily-pretreated-metastatic-castration-resistant-prostate-cancer-mcrpc-the-catch-trial
#15
Andrew J Armstrong, Michael S Humeniuk, Patrick Healy, Russell Szmulewitz, Carolyn Winters, Julie Kephart, Michael R Harrison, Elia Martinez, Kelly Mundy, Susan Halabi, Daniel George
BACKGROUND: Tasquinimod is an immunomodulating and anti-antiangiogenic oral agent with anti-prostate cancer activity in preclinical studies and in clinical trials of men with metastatic castration resistant prostate cancer (mCRPC), including single agent activity and in combination with taxanes. We sought to identify the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) of tasquinimod in combination with cabazitaxel and prednisone in men with chemorefractory mCRPC. METHODS: Men with mCRPC who had failed prior docetaxel chemotherapy received cabazitaxel 25 mg/m(2) every 3 weeks with oral tasquinimod at 1 of 3 escalating dose levels (0...
November 16, 2016: Prostate
https://www.readbyqxmd.com/read/27860163/11c-acetate-pet-ct-imaging-for-detection-of-recurrent-disease-following-radical-prostatectomy-or-radiotherapy-in-patients-with-prostate-cancer
#16
L Esch, M Fahlbusch, P Albers, H Hautzel, V Müller-Mattheis
OBJECTIVES: To evaluate the effectiveness of CT-matched 11C-acetate PET (AC-PET) in prostate cancer patients with PSA relapse following radical prostatectomy (RP) or radiotherapy (RT) in a prospective study. SUBJECTS AND METHODS: In 103 relapsing patients after RP (n=97) or RT (n=6) AC-PET images and CT scans were obtained. In PET positive patients with localized recurrence detected lesions were resected and histologically verified or -after local RT- followed-up by PSA testing...
November 8, 2016: BJU International
https://www.readbyqxmd.com/read/27853645/promoter-methylation-of-the-immune-checkpoint-receptor-pd-1-pdcd1-is-an-independent-prognostic-biomarker-for-biochemical-recurrence-free-survival-in-prostate-cancer-patients-following-radical-prostatectomy
#17
Diane Goltz, Heidrun Gevensleben, Jörn Dietrich, Jörg Ellinger, Jennifer Landsberg, Glen Kristiansen, Dimo Dietrich
Biomarkers that facilitate the prediction of disease recurrence in prostate cancer (PCa) may enable physicians to personalize treatment for individual patients. In the current study, PD-1 (PDCD1) promoter methylation was assessed in a cohort of 498 PCa patients included in The Cancer Genome Atlas (TCGA) and a second cohort of 300 PCa cases treated at the University Hospital of Bonn. In the TCGA cohort, the PD-1 promoter was significantly hypermethylated in carcinomas versus normal prostatic epithelium (55.5% vs...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27846218/muc1-expression-by-immunohistochemistry-is-associated-with-adverse-pathologic-features-in-prostate-cancer-a-multi-institutional-study
#18
Okyaz Eminaga, Wei Wei, Sarah J Hawley, Heidi Auman, Lisa F Newcomb, Jeff Simko, Antonio Hurtado-Coll, Dean A Troyer, Peter R Carroll, Martin E Gleave, Daniel W Lin, Peter S Nelson, Ian M Thompson, Lawrence D True, Jesse K McKenney, Ziding Feng, Ladan Fazli, James D Brooks
BACKGROUND: The uncertainties inherent in clinical measures of prostate cancer (CaP) aggressiveness endorse the investigation of clinically validated tissue biomarkers. MUC1 expression has been previously reported to independently predict aggressive localized prostate cancer. We used a large cohort to validate whether MUC1 protein levels measured by immunohistochemistry (IHC) predict aggressive cancer, recurrence and survival outcomes after radical prostatectomy independent of clinical and pathological parameters...
2016: PloS One
https://www.readbyqxmd.com/read/27843317/effect-of-yi-nao-jie-yu-decoction-on-%C3%AE-aminobutyric-acid-type-a-receptor-in-the-hippocampus-and-serum-inflammatory-factors-in-a-rat-model-of-poststroke-anxiety
#19
Wen Zhang, Ruizhen Zhao, Xiaoli Li, Xia Cui, Zijun Zhao, Yingqiu Mao, Fengzhi Wu, Qisheng Tang
BACKGROUND: The Yi-nao-jie-yu decoction (YNJYD) is a herbal preparation widely used in the clinics of traditional Chinese medicine and has been recently used as an important new therapeutic agent in poststroke anxiety (PSA). The neuroendocrine-immune system plays an important role in PSA mechanisms, although the modulating effects of YNJYD remain unknown. This study investigated the potential effects of YNJYD on the neuroendocrine-immune system in a rat model of PSA. MATERIALS AND METHODS: The PSA model was induced by injecting collagenase (type VII) into the right globus pallidus, accompanied by empty water bottle stimulation for 2 weeks...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27833937/external-validation-of-the-cancer-of-the-prostate-risk-assessment-postsurgical-score-for-prediction-of-disease-recurrence-after-radical-prostatectomy
#20
Taha Numan Yıkılmaz, Erdem Öztürk, Eşref Oğuz Güven, Halil Başar
Objective. The cancer of the prostate risk assessment (CAPRA-S) postsurgical score predicts recurrence, metastasis, and cancer-specific survival after radical prostatectomy (RP). We evaluated the relation between CAPRA-S score and biochemical recurrence (BCR) in prostate cancer after RP in our clinic. Materials and Methods. This study was performed on 203 patients with prostate carcinoma who underwent open RP and regional lymph node dissection in our clinic between 2008 and 2013. We calculated the CAPRA-S scores including prostate-specific antigen (PSA) at diagnosis, pathology Gleason score, surgical margin, seminal vesicle invasion, extracapsular extension, and lymph node involvement...
2016: Advances in Medicine
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