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https://www.readbyqxmd.com/read/29916251/an-enzyme-free-immunosorbent-assay-of-prostate-specific-antigen-amplified-by-releasing-ph-indicator-molecules-entrapped-in-mesoporous-silica-nanoparticles
#1
Fengying Shao, Lianhua Zhang, Lei Jiao, Xiaoying Wang, Luyang Miao, He Li, Feimeng Zhou
An enzyme-free titer plate-based colorimetric assay utilizing functionalized mesoporous silica nanoparticles (MSNs) entrapping pH-indicator molecules has been developed. Pores in the silica nanoparticles were functionalized with phenyltrimethyloxysilane so that pH indicator molecules (thymolphthalein or TP in the present case) can be tightly entrapped through ππ conjugation. To detect prostate specific antigen (PSA), the TP-containing MSNs were coated with polyethylenimine (PEI), which favors the attachment of the positively charged secondary anti-PSA antibody...
June 19, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29911685/docetaxel-treatment-in-pten-and-erg-aberrant-metastatic-prostate-cancers
#2
Pasquale Rescigno, David Lorente, David Dolling, Roberta Ferraldeschi, Daniel Nava Rodrigues, Ruth Riisnaes, Susana Miranda, Diletta Bianchini, Zafeiris Zafeiriou, Spyridon Sideris, Ana Ferreira, Ines Figueiredo, Semini Sumanasuriya, Joaquin Mateo, Raquel Perez-Lopez, Adam Sharp, Nina Tunariu, Johann S de Bono
Background: Loss of PTEN is a common genomic aberration in castration-resistant prostate cancer (CRPC) and is frequently concurrent with ERG rearrangements, causing resistance to next-generation hormonal treatment (NGHT) including abiraterone. The relationship between PTEN loss and docetaxel sensitivity remains uncertain. Objective: To study the antitumor activity of docetaxel in metastatic CRPC in relation to PTEN and ERG aberrations. Design setting and participants: Single-centre, retrospective analysis of PTEN loss and ERG expression using a previously described immunohistochemistry (IHC) binary classification system...
May 2018: European urology oncology
https://www.readbyqxmd.com/read/29909199/direct-label-free-protein-detection-in-high-ionic-strength-solution-and-human-plasma-using-dual-gate-nanoribbon-based-ion-sensitive-field-effect-transistor-biosensor
#3
Shenhui Ma, Xin Li, Yi-Kuen Lee, Anping Zhang
We report on direct label-free protein detection in high ionic strength solution and human plasma by a dual-gate nanoribbon-based ion-sensitive field-effect transistor (NR-ISFET) biosensor system with excellent sensitivity and specificity in both solution-gate (SG) and dual-gate (DG) modes. Compared with previously reported results, the NR-ISFET biosensor enables selective prostate specific antigen (PSA) detection based on antibody-antigen binding in broader detection range with lower LOD. For the first time, real-time specific detection of PSA of 10 pM to 1 μM in 100 mM phosphate buffer (PB) was demonstrated by conductance measurements using the polyethylene glycol (PEG)-modified NR-ISFET biosensors in DG mode with the back-gate bias (VBG ) of 20 V...
June 1, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29906643/the-efficacy-and-safety-comparison-of-docetaxel-cabazitaxel-estramustine-and-mitoxantrone-for-castration-resistant-prostate-cancer-a-network-meta-analysis
#4
Pan Song, Chuiguo Huang, Yan Wang
AIMS: The aim of this study was to compare the efficacy and safety of docetaxel, cabazitaxel, docetaxel + estramustine, mitoxantrone in the management of castration-resistant prostate cancer (CRPC). METHODS: Electronic databases including PubMed, Cochrance Library and Embase were searched for studies published from when the databases were established to January 1 s t, 2018. Randomized controlled trials (RCTs) that compared docetaxel + prednisone (DP), cabazitaxel + prednisone (CP), docetaxel + estramustine + prednisone (DEP), and mitoxantrone + cabazitaxel prednisone (MP) for CRPC treatment were identified...
June 12, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29904744/superior-metastasis-free-survival-for-patients-with-high-risk-prostate-cancer-treated-with-definitive-radiation-therapy-compared-to-radical-prostatectomy-a-propensity-score-matched-analysis
#5
Stephanie Markovina, Marshall W Meeks, Shahed Badiyan, Joel Vetter, Hiram A Gay, Alethea Paradis, Jeff Michalski, Gurdarshan Sandhu
Purpose: For high-risk prostate cancer (HR-PCa) in men with a life expectancy of at least 10 years, the National Comprehensive Cancer Network recommends radiation therapy (RT) plus androgen deprivation therapy (ADT) with category 1 evidence or radical prostatectomy (RP) as an acceptable initial therapy. Randomized evidence regarding which therapy is optimal for disease control is lacking for men with HR-PCa. We performed a propensity-score-matched comparison of outcomes for men with localized HR-PCa treated with primary RT or RP...
April 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29904592/prostate-specific-antigen-psa-kinetic-as-a-prognostic-factor-in-metastatic-prostate-cancer-receiving-androgen-deprivation-therapy-systematic-review-and-meta-analysis
#6
Andika Afriansyah, Agus Rizal Ardy Hariandy Hamid, Chaidir Arif Mochtar, Rainy Umbas
Aim: Metastatic prostate cancer (mPCa) has a poor outcome with median survival of two to five years. The use of androgen deprivation therapy (ADT) is a gold standard in management of this stage.  Aim of this study is to analyze the prognostic value of PSA kinetics of patient treated with hormonal therapy related to survival from several published studies Method: Systematic review and meta-analysis was performed using literature searching in the electronic databases of MEDLINE, Science Direct, and Cochrane Library...
2018: F1000Research
https://www.readbyqxmd.com/read/29901632/alloreactive-cytotoxic-t-lymphocyte-immunotherapy-treatment-of-a-patient-with-metastatic-prostate-cancer-a-case-report
#7
Junfeng Shi, Yi Chen, Yuetong Chen, Yunzhu Shen, Huanyu Zhao, Hui Sun, Jinfei Chen
RATIONALE: Cytotoxic T lymphocyte (CTL) immunotherapy is an autologous cellular immune therapy that has been approved for treating patients with malignant tumors. However, there is still limited information regarding the impact of CTL on metastatic prostate cancer (PC) patients with bone metastatic lesions. PATIENT CONCERNS: An 82-year-old male patient complained of interrupted urination, urination pain, and significant dysuria on November 24, 2014. Transurethral resection of the prostate (TURP) and postoperative pathological examination showed prostatic adenocarcinoma, and a SPECT/CT scan demonstrated multiple bone metastases...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901570/skene-s-glands-adenocarcinoma-a-series-of-4-cases
#8
Aline C Tregnago, Jonathan I Epstein
Skene's (periurethral) gland adenocarcinoma is very rare, with only 7 cases reported in the literature. This is the first series of cases on this entity. We describe the histologic, immunohistochemical, and clinical findings of 4 patients with Skene's gland adenocarcinoma retrieved from the Johns Hopkins Urologic Pathology Consult Service from 1984 to 2017. The average age at diagnosis of the 4 women was 74.5 years (range, 61 to 87 y). Tumors were treated by limited resections with negative margins. Tumor size ranged from 1...
June 12, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29900823/biochemical-recurrence-after-robot-assisted-extended-pelvic-lymphadenectomy-for-prostate-cancer
#9
Avinash Chenam, Nora Ruel, Sumanta Pal, John Barlog, Clayton Lau, Timothy Wilson, Bertram Yuh
INTRODUCTION: Extended lymph node dissection (ELND) compared to limited lymph node dissection (LLND) at time of prostatectomy improves staging and lymph node (LN) yield. The effect on biochemical recurrence (BCR) and survival is less well understood. We sought to evaluate the benefit of robotic ELND and LLND with respect to BCR. MATERIALS AND METHODS: Between 2008-2012, 584 consecutive men with intermediate or high risk clinically localized adenocarcinoma of the prostate underwent robotic assisted radical prostatectomy (RARP) with concomitant LLND (n = 326) or ELND (n = 258)...
June 2018: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29891440/three-year-interim-results-of-overall-and-progression-free-survival-in-a-cohort-of-patients-with-prostate-cancer-gescap-group
#10
J M Cózar, B Miñana, F Gómez-Veiga, A Rodríguez-Antolín
AIMS: To describe the 3-year progression-free survival (PFS), overall survival (OS) and disease-specific mortality in the prospective prostate cancer GESCAP cohort, as well as the progression to castration resistance in patients on hormone therapy. MATERIAL AND METHODS: Prospective, observational, epidemiological, multicentre study. Of the 4087 patients recruited, 3843 were evaluable. The variables analysed were the risk group (localized, locally advanced, lymph involvement, metastatic), age, prostate-specific antigen (PSA) levels, Gleason score and initial treatment...
June 8, 2018: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/29890979/long-term-oncologic-outcomes-of-radiotherapy-combined-with-maximal-androgen-blockade-for-localized-high-risk-prostate-cancer
#11
Yong Luo, Mingchuan Li, Hengzhi Qi, Jiahui Zhao, Yili Han, Yunhua Lin, Zhu Hou, Yongguang Jiang
BACKGROUND: To assess the oncologic outcomes of radiation therapy (RT) combined with maximal androgen blockade (MAB) and prostate-specific antigen (PSA) kinetics in patients with localized, high-risk prostate carcinoma (PCa). METHODS: Three-hundred twenty individuals with localized PCa who underwent RT + MAB in 2001-2015 were evaluated retrospectively. All patients had received 36 months of MAB therapy and 45 Gy of pelvic irradiation, plus a dose-escalated external beam radiation therapy (DE-EBRT) boost to 76~81 Gy (MAB + EBRT group), or a low-dose-rate prostate permanent brachytherapy (LDR-PPB) boost to 110 Gy with I-125 (MAB + EBRT + PPB group)...
June 11, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29887700/clinical-significance-of-incidental-prostatic-carcinoma-on-radical-cystectomy-histology-specimens-a-clinicopathological-and-survival-analysis
#12
Dharma Ram, Suhas K Rajappa, Sudhir Rawal, Amitabh Singh, Kailash Chand Sharma, Ajay Kumar Dewan
Incidental prostatic carcinoma on radical cystectomy histology specimens is not an uncommon entity and managing such cases is still controversial. Classification into clinically significant and insignificant cancers by Epstein based on the assumption that one is more likely to affect the survival than the other is not universally accepted. We conducted this retrospective analysis with the aim to find out the role of dichotomization of incidental prostatic cancer into such classification. Patient's data were retrospectively reviewed from January 2013 to December 2014...
June 2018: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29887239/effect-of-multimodal-analgesia-with-paravertebral-blocks-on-biochemical-recurrence-in-men-undergoing-open-radical-prostatectomy
#13
Liam C Macleod, Robert M Turner, Samia Lopa, Lee A Hugar, Benjamin J Davies, Bruce Ben-David, Jacques E Chelly, Bruce L Jacobs, Joel B Nelson
BACKGROUND: Recent studies suggest that anesthetic technique during radical prostatectomy for prostate cancer may affect recurrence or progression. This association has previously been investigated in series that employ epidural analgesia. The objective of this study is to determine the association between the use of a multimodal analgesic approach incorporating paravertebral blocks and risk of biochemical recurrence following open radical prostatectomy. PATIENTS AND METHODS: Using a prospective database of 3,029 men undergoing open radical prostatectomy by a single surgeon, we identified 2,909 men who received no neoadjuvant androgen deprivation and had at least 1 year of follow up...
June 7, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29886377/metal-and-redox-homeostasis-in-prostate-cancer-with-vitamin-d-3-supplementation
#14
Krisztina Süle, Klára Szentmihályi, Gergő Szabó, Dénes Kleiner, Imre Varga, Anna Egresi, Zoltán May, Péter Nyirády, Miklós Mohai, Anna Blázovics
Vitamin D3 supplementation has a beneficial effect on cancerous patients, although it can influence the redox- and metal homeostasis. The aim of our investigation was to demonstrate the effect of vitamin D3 consumption on the redox- and metal homeostasis in prostate cancer, because of the recommended daily dose increased from 200 IU to 2000 IU in recent years in Hungary. Forty-three volunteers were involved in the study. The grouping was applied according to the clinical routine laboratory parameters (vitamin D3 ) and the tumor markers (PSA, fPFA)...
June 7, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29882332/treatment-selection-for-men-with-metastatic-prostate-cancer-who-progress-on-upfront-chemo-hormonal-therapy
#15
Pedro Barata, Hamid Emamekhoo, Prateek Mendiratta, Vadim Koshkin, Allison Tyler, Moshe Ornstein, Brian I Rini, Timothy Gilligan, Christos Kyriakopoulos, Jorge A Gracia
BACKGROUND: Androgen deprivation therapy plus docetaxel (D-ADT) increases overall survival (OS) in men with high-volume, metastatic hormone-sensitive prostate cancer (mHSPC). Although the vast majority of men initially respond to D-ADT, most will progress and develop castration-resistant prostate cancer (CRPC). Little is known about the optimal treatment sequence for men with progressive disease on D-ADT. PATIENT AND METHODS: Retrospective analysis of consecutive mHSPC patients treated with ≥3 cycles of D-ADT at Cleveland Clinic and University of Wisconsin-Madison was undertaken...
June 7, 2018: Prostate
https://www.readbyqxmd.com/read/29869455/impact-of-early-salvage-androgen-deprivation-therapy-in-localized-prostate-cancer-after-radical-prostatectomy-a-propensity-score-matched-analysis
#16
Jae Won Park, Won Sik Jang, Dong Hoon Koh, Won Sik Ham, Koon Ho Rha, Sung Joon Hong, Young Deuk Choi
PURPOSE: Androgen deprivation therapy (ADT) is used as a salvage treatment for men with biochemical recurrence (BCR) of prostate cancer (PCa) following initial radical prostatectomy (RP). The optimal time at which to begin salvage ADT (sADT) remains controversial. In this retrospective study, we evaluated the efficacy of initiating sADT in patients before prostate-specific antigen (PSA) values met the clinical definition of BCR. MATERIALS AND METHODS: We identified 484 PCa patients who received sADT for BCR after RP...
July 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29861410/rankprod-combined-with-genetic-algorithm-optimized-artificial-neural-network-establishes-a-diagnostic-and-prognostic-prediction-model-that-revealed-c1qtnf3-as-a-biomarker-for-prostate-cancer
#17
Qi Hou, Zhi-Tong Bing, Cheng Hu, Mao-Yin Li, Ke-Hu Yang, Zu Mo, Xiang-Wei Xie, Ji-Lin Liao, Yan Lu, Shigeo Horie, Ming-Wu Lou
Prostate cancer (PCa) is the most commonly diagnosed cancer in males in the Western world. Although prostate-specific antigen (PSA) has been widely used as a biomarker for PCa diagnosis, its results can be controversial. Therefore, new biomarkers are needed to enhance the clinical management of PCa. From publicly available microarray data, differentially expressed genes (DEGs) were identified by meta-analysis with RankProd. Genetic algorithm optimized artificial neural network (GA-ANN) was introduced to establish a diagnostic prediction model and to filter candidate genes...
May 31, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29861341/nitric-oxide-in-frozen-thawed-equine-sperm-effects-on-motility-membrane-integrity-and-sperm-capacitation
#18
André F C de Andrade, Rubens P Arruda, Mariana A Torres, Naira C G Pieri, Ticiano G Leite, Eneiva Carla C Celeghini, Leticia Z Oliveira, Thayna P Gardés, Maria Clara C Bussiere, Daniela F Silva
Nitric oxide (NO) is a reactive nitrogen species (RSN) that, over the years, has been shown to be integrated with biological and physiological events, including reproductive processes. NO can affect the functionality of spermatozoa through free radical scavenging, deactivating and inhibiting the production of superoxide anions (O2 .- ). However, the role of NO in mammalian spermatozoa physiology seems paradoxical. The aim of this study was to investigate the effects of NO on motility, hyperactivation, membrane integrity, peroxidation, and capacitation in cryopreserved equine sperm...
May 22, 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29861336/long-term-oncologic-results-of-anatomic-vs-parenchyma-sparing-resection-for-hepatocellular-carcinoma-a-propensity-score-matching-analysis
#19
Simone Famularo, Stefano Di Sandro, Alessandro Giani, Andrea Lauterio, Marta Sandini, Riccardo De Carlis, Vincenzo Buscemi, Fabrizio Romano, Luca Gianotti, Luciano De Carlis
PURPOSE: The extent of liver resection for the optimal treatment of hepatocellular carcinoma (HCC) is debated. The purpose of this study was to compare the impact of anatomic resection (AR) vs. parenchyma-sparing resection (PSR) on disease recurrence and patient survival. METHODS: We retrospectively analyzed patients with HCC who underwent liver resection from January 2001 to August 2015. Patients receiving AR or PSR were compared by a propensity score analysis (PSA) (caliper = 0...
May 22, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29861328/-active-surveillance-in-prostate-cancer-assessment-of-mri-in-the-selection-and-follow-up-of-patients
#20
A Raichi, G Marcq, J-C Fantoni, P Puech, A Villers, A Ouzzane
AIM: To evaluate the contribution of multiparametric MRI (MRI) and targeted biopsies (TB) in the selection and follow-up of patients under active surveillance (AS). METHODS: A single-center, retrospective cohort study on 131 patients in AS, with following criteria:≤cT2 stage, PSA≤15ng/mL, Gleason score≤6,≤3 positive biopsies and maximum tumor length≤5mm. Patients' selection and follow-up was performed by the combination of systemic biopsies (SB) and mpMRI±TB...
May 31, 2018: Progrès en Urologie
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