keyword
MENU ▼
Read by QxMD icon Read
search

Prostatic specific antigen

keyword
https://www.readbyqxmd.com/read/29235134/sex-hormone-binding-globulin-is-associated-with-androgen-deficiency-features-independently-of-total-testosterone
#1
Giulia Rastrelli, Giovanni Corona, Sarah Cipriani, Edoardo Mannucci, Mario Maggi
OBJECTIVE: It is recognized that total testosterone (TT) does not sufficiently describe androgen status when sex hormone binding globulin (SHBG) is altered. However, in humans, evidence supporting the existence of a hypogonadism due to low T bioactivity is scanty. The aim of the study was to assess whether changes in SHBG levels, independently of TT, are associated with subjective and objective androgen dependent parameters. DESIGN: Cross-sectional observation. PATIENTS: 2622 men (aged 51...
December 13, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29234267/incidental-detection-of-occult-thyroid-carcinoma-with-11c-choline-pet-ct-for-high-risk-prostate-cancer
#2
Adama Ouattara, Tiago Ribeiro de Oliveira, Serge Holz, Hannes Van den Bossche, David Strybol, Christophe Assenmacher, Wouter Everaerts, Gert De Meerleer, Steven Joniau
We report a case of a 65-year-old male patient with high-risk prostate cancer, re-staged with 11C-choline positron emission tomography/computed tomography (PET/CT) for prostate specific antigen recurrences 3 years after radical prostatectomy and adjuvant radiation therapy. In addition to 2 suspicious presacral lymph nodes which were resected and proven to be metastatic, PET/CT revealed a very high uptake in a calcified thyroid nodule. Evaluation with fine needle aspiration was suspicious for thyroid carcinoma and the patient underwent total thyroidectomy, confirming a non-metastatic encapsulated follicular variant of papillary thyroid carcinoma...
November 2017: Current Urology
https://www.readbyqxmd.com/read/29234265/the-benefit-of-a-surgical-resection-of-a-solitary-pulmonary-metastasis-of-prostate-cancer-after-radical-prostatectomy
#3
Dries Mortier, Evert Baten, Kurt Vandeurzen, Koenraad van Renterghem
Historically, a solitary pulmonary metastasis of prostate cancer was considered as metastatic or disseminated disease and could only be treated systemically. However, some patients may benefit from surgical metastasectomy of a solitary pulmonary metastasis. We present an uncommon case of resection of a solitary pulmonary metastasis of prostate cancer after previous radical prostatectomy, resulting in un-detectable prostate specific antigen.
November 2017: Current Urology
https://www.readbyqxmd.com/read/29234263/atypical-small-acinar-proliferation-and-high-grade-prostatic-intraepithelial-neoplasia-should-we-be-concerned-an-observational-cohort-study-with-a-minimum-follow-up-of-3-years
#4
Vinaya Srirangam, Bhavan Prasad Rai, Ahmed Abroaf, Samita Agarwal, Sergey Tadtayev, Charlotte Foley, Tim Lane, Jim Adshead, Nikhil Vasdev
Introduction: Atypical small acinar proliferation (ASAP) and high grade prostatic intraepithelial neoplasia (HGPIN) are considered precancerous. We aimed to measure the rate of repeat biopsy and adenocarcinoma in patients with ASAP and HGPIN and identify any clinico-pathologic parameters at diagnosis of ASAP/HGPIN that are predictive of adenocarcinoma. Materials and Methods: Patients with a diagnosis of ASAP/HGPIN with no previous or concomitant cancer were identified...
November 2017: Current Urology
https://www.readbyqxmd.com/read/29234259/simultaneous-measurements-of-follicle-stimulating-hormone-and-total-testosterone-and-associations-in-clinically-localized-prostate-cancer
#5
Antonio B Porcaro, Salvatore Siracusano, Nicolò de Luyk, Paolo Corsi, Marco Sebben, Alessandro Tafuri, Tania Processali, Davide Inverardi, Giovanni Cacciamani, Daniele Mattevi, Maria A Cerruto, Matteo Brunelli, Claudio Ghimenton, Carmelo Monaco, Walter Artibani
Objectives: To evaluate the potential relations of simultaneous measurements of basal levels of follicle stimulating hormone (FSH) and total testosterone (TT) in clinically localized prostate cancer (PCa). Materials and Methods: The study included 126 patients who had simultaneous measurements of prostate specific antigen (PSA), FSH, and TT before undergoing radical prostatectomy for clinically localized PCa. Correlations and independent associations between clinical and pathological factors were investigated by statistical methods...
November 2017: Current Urology
https://www.readbyqxmd.com/read/29234244/genetic-alterations-in-benign-prostatic-hyperplasia-patients
#6
Hanaa Mahmoud Mohamed, Magdy Sayed Aly, Tarek Dardeer Hussein
Background: Benign prostate hyperplasia (BPH) is a classical age-related disease of the prostate, present in 20% of men at the age of 40 years with progression to 70% by the age of 60 years. BPH is associated with various lower urinary tract symptoms, which affect their day-to-day life. Materials and methods: Our objective was to evaluate the association between HER-2/neu, c-myc, p53, and clinicopathological variables in 45 patients diagnosed with benign prostatic hyperplasia using fluorescence in situ hybridization (FISH)...
2017: German Medical Science: GMS E-journal
https://www.readbyqxmd.com/read/29233664/performance-of-a-prostate-cancer-genomic-classifier-in-predicting-metastasis-in-men-with-prostate-specific-antigen-persistence-postprostatectomy
#7
Daniel E Spratt, Darlene L Y Dai, Robert B Den, Patricia Troncoso, Kasra Yousefi, Ashley E Ross, Edward M Schaeffer, Zaid Haddad, Elai Davicioni, Rohit Mehra, Todd M Morgan, Walter Rayford, Firas Abdollah, Edouard Trabulsi, Mary Achim, Elsa Li Ning Tapia, Mireya Guerrero, Robert Jeffrey Karnes, Adam P Dicker, Mark A Hurwitz, Paul L Nguyen, Felix F Y Feng, Stephen J Freedland, John W Davis
BACKGROUND: Prostate cancer patients who have a detectable prostate-specific antigen (PSA) postprostatectomy may harbor pre-existing metastatic disease. To our knowledge, none of the commercially available genomic biomarkers have been investigated in such men. OBJECTIVE: To evaluate if a 22-gene genomic classifier can independently predict development of metastasis in men with PSA persistence postoperatively. DESIGN, SETTING, AND PARTICIPANTS: A multi-institutional study of 477 men who underwent radical prostatectomy (RP) between 1990 and 2015 from three academic centers...
December 9, 2017: European Urology
https://www.readbyqxmd.com/read/29232987/radium-223-international-early-access-program-results-from-the-spanish-subset
#8
Joan Carles, Mª José Méndez, Álvaro Pinto, Mª Isabel Sáez, José A Arranz, Pablo Maroto, Pilar López-Criado, Begoña Mellado, Jesús García Donas, Susana Hernando, Luís León, Aránzazu González Del Alba, Núria Laínez, Emilio Esteban, Gaspar Reynés, José L Pérez-Gracia, Josep R Germà, Marta López-Brea, Begoña Pérez-Valderrama, Cristina Moretones, Daniel Castellano
AIM: To report results from the Spanish subset included in the radium-223 international early access program (iEAP). PATIENTS & METHODS: Ninety patients with castration-resistant prostate cancer and bone metastases received radium-223 55 kBq/kg every 4 weeks for six cycles. RESULTS: The median time to disease progression was 8 months and to prostate-specific antigen progression was 4 months. The percentage of patients with ≥50% confirmed declines in prostate-specific antigen was 9%...
December 13, 2017: Future Oncology
https://www.readbyqxmd.com/read/29232247/salivary-gland-activity-obscures-mandibular-metastasis-of-prostate-carcinoma-on-68ga-prostate-specific-membrane-antigen-pet
#9
Thabo Lengana, Ismaheel Lawal, Tebatso Boshomane, Kehinde Ololade, Florette Reyneke, Chimbabantiu Kaoma, Neo Mokgoro, Mariza Vorster, Mike Sathekge
We report a case of a 65-year-old man with prostate cancer; his treatment history included radical prostatectomy followed by radiation therapy and subsequent androgen deprivation therapy for more than 5 years. He currently presented with a history of rising prostate-specific antigen and complained of jaw aches. Ga-prostate-specific membrane antigen PET/CT study performed for suspected biochemical recurrence demonstrated vertebral lesions and lesion in his jaw. Subsequent biopsy of jaw lesion demonstrated prostate cancer metastases...
December 11, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29232245/intense-68ga-psma-uptake-in-diverticulum-of-the-sigmoid-colon
#10
Mads Ryø Jochumsen, Kirsten Bouchelouche
We present a case of a diverticulum of the sigmoid colon with intense prostate-specific membrane antigen (PSMA) activity on Ga-PSMA PET/CT. CT scan and colonoscopy showed no signs of inflammation or malignancy. This case presents an addition to the collection of benign pitfalls when reporting PSMA PET/CT; however, a Ga-PSMA up-taking focus in the colon should always cause further examination, as malignant etiology must be ruled out.
December 11, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29231973/comparative-effectiveness-of-prostate-cancer-screening-between-the-ages-of-55-and-69-years-followed-by-active-surveillance
#11
Tiago M de Carvalho, Eveline A M Heijnsdijk, Harry J de Koning
BACKGROUND: Because of the recent grade C draft recommendation by the US Preventive Services Task Force (USPSTF) for prostate cancer screening between the ages of 55 and 69 years, there is a need to determine whether this could be cost-effective in a US population setting. METHODS: This study used a microsimulation model of screening and active surveillance (AS), based on data from the European Randomized Study of Screening for Prostate Cancer and the Surveillance, Epidemiology, and End Results Program, for the natural history of prostate cancer and Johns Hopkins AS cohort data to inform the probabilities of referral to treatment during AS...
December 12, 2017: Cancer
https://www.readbyqxmd.com/read/29231972/prostate-cancer-screening-with-prostate-specific-antigen-where-are-we-going
#12
EDITORIAL
Peter C Albertsen
No abstract text is available yet for this article.
December 12, 2017: Cancer
https://www.readbyqxmd.com/read/29231500/-impacts-of-electroacupuncture-on-benign-prostatic-hyperplasia-and-the-levels-of-estrogen-and-androgen-in-patients
#13
Ruwen Zheng, Hui Hu
OBJECTIVE: To discuss the therapeutic effects of electroacupuncture on benign prostatic hyperplasia and the impacts on hormone levels in the patients. METHODS: Sixty patients were randomized into an electroacupuncture group and a medication group, 30 cases in each one. In the electroacupuncture group, electroacupuncture was applied to Zhongji (CV 3) and Qugu (CV 2), once a day, 5 times a week. In the medication group, tamsulosin hydrochloride sustained-release capsules were prescribed for oral administration, 0...
June 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29230043/nanoparticle-orientation-to-control-rna%C3%A2-loading-and-ligand-display-on-extracellular-vesicles-for-cancer-regression
#14
Fengmei Pi, Daniel W Binzel, Tae Jin Lee, Zhefeng Li, Meiyan Sun, Piotr Rychahou, Hui Li, Farzin Haque, Shaoying Wang, Carlo M Croce, Bin Guo, B Mark Evers, Peixuan Guo
Nanotechnology offers many benefits, and here we report an advantage of applying RNA nanotechnology for directional control. The orientation of arrow-shaped RNA was altered to control ligand display on extracellular vesicle membranes for specific cell targeting, or to regulate intracellular trafficking of small interfering RNA (siRNA) or microRNA (miRNA). Placing membrane-anchoring cholesterol at the tail of the arrow results in display of RNA aptamer or folate on the outer surface of the extracellular vesicle...
December 11, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/29230006/platinum-sensitivity-in-metastatic-prostate-cancer-does-histology-matter
#15
Michael S Humeniuk, Rajan T Gupta, Patrick Healy, Megan McNamara, Sundhar Ramalingam, Michael Harrison, Daniel George, Tian Zhang, Yuan Wu, Andrew J Armstrong
BACKGROUND: Platinum-based chemotherapy is effective in men with neuroendocrine prostate cancer (NEPC), but it is unclear whether histology (adenocarcinoma vs. non-adenocarcinoma NEPC variants) is predictive of platinum sensitivity. Given that NEPC exists as a spectrum, there may be men with adenocarcinoma who might benefit from platinum chemotherapy, particularly those men with DNA repair defects. METHODS: This was a retrospective study of all of the men seen at Duke University since 2005 who had metastatic castration-resistant prostate cancer (mCRPC) and were treated with a platinum agent...
December 11, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29229325/prospective-phase-2-trial-of-permanent-seed-implantation-prostate-brachytherapy-for-intermediate-risk-localized-prostate-cancer-efficacy-toxicity-and-quality-of-life-outcomes
#16
Steven J Frank, Thomas J Pugh, Pierre Blanchard, Usama Mahmood, William J Graber, Rajat J Kudchadker, John W Davis, Jeri Kim, Haesun Choi, Patricia Troncoso, Deborah A Kuban, Seungtaek Choi, Sean McGuire, Karen E Hoffman, Hsiang-Chun Chen, Xuemei Wang, David A Swanson
PURPOSE: To report the efficacy, physician-reported toxicity, and patient-reported outcomes of men with intermediate-risk prostate cancer after brachytherapy in a prospective phase 2 trial. METHODS AND MATERIALS: This prospective phase 2 trial involved 300 patients with previously untreated prostate cancer treated from 2006 through 2013. Eligible patients had ≤cT2b (T3 excluded according to magnetic resonance imaging), Gleason score (GS) 6 with prostate-specific antigen (PSA) level 10-15 ng/mL, or GS 7 with PSA <10 ng/mL, and were treated with prostate brachytherapy (without hormonal therapy)...
October 12, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29229176/use-of-concomitant-androgen-deprivation-therapy-in-patients-treated-with-early-salvage-radiotherapy-for-biochemical-recurrence-after-radical-prostatectomy-long-term-results-from-a-large-multi-institutional-series
#17
Giorgio Gandaglia, Nicola Fossati, R Jeffrey Karnes, Stephen A Boorjian, Michele Colicchia, Alberto Bossi, Thomas Seisen, Cesare Cozzarini, Nadia Di Muzio, Barbara Noris Chiorda, Emanuele Zaffuto, Thomas Wiegel, Shahrokh F Shariat, Gregor Goldner, Steven Joniau, Antonino Battaglia, Karin Haustermans, Gert De Meerleer, Valérie Fonteyne, Piet Ost, Hendrick Van Poppel, Francesco Montorsi, Alberto Briganti
BACKGROUND: Hormonal manipulation concomitant to salvage radiotherapy (SRT) given for biochemical recurrence (BCR) after radical prostatectomy (RP) improved outcomes in two randomized trials. However, neither of these studies focused on men treated at low prostate-specific antigen (PSA) levels. OBJECTIVE: To test if the impact of androgen deprivation therapy (ADT) on metastasis in patients undergoing early SRT varies according to prostate cancer (PCa) features. DESIGN, SETTING, AND PARTICIPANTS: A total of 525 patients received SRT at PSA levels ≤2ng/ml...
December 8, 2017: European Urology
https://www.readbyqxmd.com/read/29226826/prostate-magnetic-resonance-imaging-interpretation-varies-substantially-across-radiologists
#18
Geoffrey A Sonn, Richard E Fan, Pejman Ghanouni, Nancy N Wang, James D Brooks, Andreas M Loening, Bruce L Daniel, Katherine J To'o, Alan E Thong, John T Leppert
BACKGROUND: Multiparametric magnetic resonance imaging (mpMRI) interpreted by experts is a powerful tool for diagnosing prostate cancer. However, the generalizability of published results across radiologists of varying expertise has not been verified. OBJECTIVE: To assess variability in mpMRI reporting and diagnostic accuracy across radiologists of varying experience in routine clinical care. DESIGN, SETTING, AND PARTICIPANTS: Men who underwent mpMRI and MR-fusion biopsy between 2014-2016...
December 6, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29226251/tissue-based-biomarkers-in-prostate-cancer
#19
Timothy N Clinton, Aditya Bagrodia, Yair Lotan, Vitaly Margulis, Ganesh V Raj, Solomon L Woldu
Introduction: Prostate cancer is a heterogeneous disease. Existing risk stratification tools based on standard clinlicopathologic variables (prostate specific antigen [PSA], Gleason score, and tumor stage) provide a modest degree of predictive ability. Advances in high-throughput sequencing has led to the development of several novel tissue-based biomarkers that can improve prognostication in prostate cancer management. Areas Covered: The authors review commercially-available, tissue-based biomarker assays that improve upon existing risk-stratification tools in several areas of prostate cancer management, including the appropriateness of active surveillance and aiding in decision making regarding the use of adjuvant therapy...
2017: Expert Review of Precision Medicine and Drug Development
https://www.readbyqxmd.com/read/29225060/functional-recovery-oncologic-outcomes-and-postoperative-complications-12-months-following-robot-assisted-radical-prostatectomy-follow-up-of-an-evidence-based-analysis-comparing-the-retzius-sparing-and-standard-approaches
#20
Mani Menon, Deepansh Dalela, Marcus Jamil, Mireya Diaz, Christopher Tallman, Firas Abdollah, Akshay Sood, Linda Lehtola, David Miller, Wooju Jeong
PURPOSE: To report 1-year update of functional (urinary and sexual) recovery, oncological outcomes, and postoperative complications in patients who completed a randomized controlled trial comparing posterior (Retzius-sparing) with anterior robot-assisted radical prostatectomy (RARP). MATERIAL AND METHODS: One-hundred twenty patients with clinically low-intermediate risk prostate cancer (PCa) were randomized to undergo posterior (n=60) or anterior RARP (n=60) by a single surgical team at an academic institution...
December 7, 2017: Journal of Urology
keyword
keyword
25552
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"