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Prostatic specific antigen

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https://www.readbyqxmd.com/read/28430620/genetic-association-between-psa-158g-a-polymorphism-and-the-susceptibility-of-benign-prostatic-hyperplasia-a-meta-analysis
#1
REVIEW
Xin-Jun Su, Xian-Tao Zeng, Cheng Fang, Tong-Zu Liu, Xing-Huan Wang
Inconsistency between reported findings on the association of prostate specific antigen (PSA) gene -158G/A polymorphism with benign prostatic hyperplasia (BPH) susceptibility need a meta-analysis to obtain a more accurate conclusion. A systematic search was conducted in electronic databases for the collection of eligible studies on PSA -158G/A polymorphism and BPH susceptibility. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were then calculated. 7 case-control studies with 758 cases and 752 controls were included into the present meta-analysis...
February 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28430341/prostate-specific-antigen-increase-during-dutasteride-to-indicate-the-need-for-prostate-biopsy-influence-of-prostatic-inflammation
#2
Alessandro Sciarra, Martina Maggi, Andrea Fasulo, Stefano Salciccia, Vincenzo Gentile, Susanna Cattarino, Alessandro Gentilucci
INTRODUCTION: The aim of this study was to analyze the significance of an increase in total prostate-specific antigen (PSA) serum levels despite dutasteride treatment as a predictor of prostate cancer (PC) at biopsy. We focused our attention on the rate of the first PSA increase and on the influence of prostatic inflammation. METHODS: From 2011 to 2016, 365 men with a previous negative prostate biopsy and persistent elevated PSA levels received dutasteride treatment...
April 4, 2017: Urologia
https://www.readbyqxmd.com/read/28427756/human-tissue-kallikreins-blood-levels-and-response-to-radiotherapy-in-intermediate-risk-prostate-cancer
#3
Nicola J Nasser, John Thoms, Antoninus Soosaipillai, Melania Pintilie, Ri Wang, Eleftherios P Diamandis, Robert G Bristow
OBJECTIVES: Kallikreins are serine proteases over expressed in many malignancies. In this study, we measure changes in serum kallikrein (KLKs) levels during intensity-modulated radiotherapy (IMRT) in prostate cancer patients, and find potential correlations between serum kallikrein level and normal tissues toxicity during radiation. METHODS: Forty-nine patients with prostate cancer were recruited as follows: group 1, definitive standard fractionation IMRT (78Gy in 39 fractions, n=15); group 2, definitive hypofractionated IMRT (60Gy in 20 fractions, n=15); and group 3, IMRT postprostatectomy (66Gy in 33 fractions, n=19)...
April 17, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28427078/a-case-of-adult-metastatic-rhabdomyosarcoma-of-the-prostate-cured-by-long-term-chemotherapy-with-local-radiation
#4
Masato Konno, Koji Mitsuzuka, Shigeyuki Yamada, Shinichi Yamashita, Yasuhiro Kaiho, Akihiro Ito, Mika Watanabe, Yoichi Arai
A 32-year-old man visited our hospital due to urinary retention. Prostate-specific antigen was 13.7 ng/mL. Imaging examinations showed a large prostatic tumor and lung and internal iliac lymph node metastases. Transrectal biopsy confirmed embryonal rhabdomyosarcoma of the prostate classified as cT2bN1M1 (stage IV) by the International Rhabdomyosarcoma Study (IRS) Group staging system. Systemic chemotherapy was started according to the IRS III regimen 36, which consisted of 16 weeks of induction chemotherapy with radiation...
April 21, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28426464/comparative-effectiveness-in-urology-a-state-of-the-art-review-utilizing-a-systematic-approach
#5
Jathin Bandari, Charles B Wessel, Bruce L Jacobs
PURPOSE OF REVIEW: Comparative effectiveness research plays a vital role in healthcare delivery by guiding evidence-based practices. We performed a state-of-the-art review of comparative effectiveness research in the urology literature for 2016, utilizing a systematic approach. Seven high-impact papers are reviewed in detail. RECENT FINDINGS: Across the breadth of urology, there were several important studies in comparative effectiveness research, of which we will highlight two randomized controlled trials and five observational trials: radiotherapy, prostatectomy, and active monitoring have equivalent mortality outcomes in patients with localized prostate cancer; the ideal modality of patient education is yet to be determined, and written education has minimal effect on patient perception of prostate specific antigen screening; robotic prostatectomy is associated with higher perioperative complication rates on a population basis; racial disparities exist in incontinence rates after treatment for localized prostate cancer, but not in irritative, bowel, or sexual function; androgen deprivation therapy is associated with higher fracture, peripheral artery disease, and cardiac-related complications than bilateral orchiectomy; robotic and open cystectomy offer comparable cancer-specific mortality and perioperative outcomes; and bonuses for low-cost hospitals can inadvertently reward low-quality hospitals...
April 19, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28422738/peripheral-zone-volume-ratio-pz-ratio-is-relevant-with-biopsy-results-and-can-increase-the-accuracy-of-current-diagnostic-modality
#6
Yifan Chang, Rui Chen, Qingsong Yang, Xu Gao, Chuanliang Xu, Jianping Lu, Yinghao Sun
The current diagnostic modality of prostate cancer based on prostate specific antigen (PSA) and systematic biopsy is far from ideal in terms of over-diagnosing indolent prostate cancer and missing significant ones. Thus we integrated the peripheral zone volume ratio (PZ-ratio) for diagnostic refinement. This retrospective study included 247 consecutive patients who underwent initial transrectal ultrasound-guided systematic prostate biopsy from April 2014 to November 2015. Prostate volume was determined by semi-automatic contour on axial T2 weighted magnetic resonance imaging (MRI)...
March 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28420168/comparative-study-of-blood-based-biomarkers-%C3%AE-2-3-sialic-acid-psa-and-phi-for-high-risk-prostate-cancer-detection
#7
Montserrat Ferrer-Batallé, Esther Llop, Manel Ramírez, Rosa Núria Aleixandre, Marc Saez, Josep Comet, Rafael de Llorens, Rosa Peracaula
Prostate Specific Antigen (PSA) is the most commonly used serum marker for prostate cancer (PCa), although it is not specific and sensitive enough to allow the differential diagnosis of the more aggressive tumors. For that, new diagnostic methods are being developed, such as PCA-3, PSA isoforms that have resulted in the 4K score or the Prostate Health Index (PHI), and PSA glycoforms. In the present study, we have compared the PHI with our recently developed PSA glycoform assay, based on the determination of the α2,3-sialic acid percentage of serum PSA (% α2,3-SA), in a cohort of 79 patients, which include 50 PCa of different grades and 29 benign prostate hyperplasia (BPH) patients...
April 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28418690/pi-rads-version-2-detection-of-clinically-significant-cancer-in-patients-with-biopsy-gleason-score-6-prostate-cancer
#8
Ji Won Seo, Su-Jin Shin, Young Taik Oh, Dae Chul Jung, Nam Hoon Cho, Young Deuk Choi, Sung Yoon Park
OBJECTIVE: The purpose of this study was to analyze the utility of the Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) in the detection of a clinically significant cancers in patients with prostate cancers with a biopsy Gleason score of 6. MATERIALS AND METHODS: A group of 182 consecutively registered patients with biopsy-proven prostate cancer with a Gleason score of 6 underwent MRI and radical prostatectomy. Clinically significant cancer was surgically defined as Gleason score of 7 or greater, tumor volume of 0...
April 18, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28418634/protein-trapping-in-plasmonic-nanoslit-and-nanoledge-cavities-the-behavior-and-sensing
#9
Zheng Zeng, Xiaojun Shi, Taylor Mabe, Shaun Christie, Grant Gilmore, Adam W Smith, Jianjun Wei
A novel plasmonic nanoledge device was presented to explore the geometry-induced trapping of nanoscale biomolecules and examine a generation of surface plasmon resonance (SPR) for plasmonic sensing. To design an optimal plasmonic device, a semi-analytical model was implemented for a quantitative analysis of SPR under plane-wave illumination and a finite-difference time-domain (FDTD) simulation was used to study the optical transmission and refractive index (RI) sensitivity. In addition, total internal reflection fluorescence (TIRF) imaging was used to visualize the migration of fluorescently labeled bovine serum albumin (BSA) into the nanoslits; and fluorescence correlation spectroscopy (FCS) was further used to investigate the diffusion of BSA in the nanoslits...
April 18, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28417057/evaluation-of-shla-g-levels-in-serum-of-patients-with-prostate-cancer-identify-as-a-potential-of-tumor-marker
#10
Mohammad Hassan Heidari, Abolfazl Movafagh, Mohammad-Amin Abdollahifar, Shabnam Abdi, Mohamadreza Mashhoudi Barez, Hadi Azimi, Afshin Moradi, Amin Bagheri, Matineh Heidari, Jafar Hessam Mohseni, Maryam Tadayon, Hoda Mirsafian, Mahdi Ghatrehsamani
Prostate cancer is the most common cancer type in men and is the second cause of death, due to cancer, in patients over 50, after lung cancer. Prostate specific antigen (PSA) is a widely used tumor marker for prostate cancer. Recently, PSA is discovered in non-prostatic cancer tissues in men and women raising doubts about its specificity for prostatic tissues. PSA exists in low serum level in healthy men and in higher levels in many prostate disorders, including prostatitis and prostate cancer. Thus, a supplementary tumor marker is needed to accurately diagnose the cancer and to observe the patient after treatment...
March 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/28416350/survival-among-men-at-high-risk-of-disseminated-prostate-cancer-receiving-initial-locally-directed-radical-treatment-or-initial-androgen-deprivation-therapy
#11
Prasanna Sooriakumaran, Tommy Nyberg, Olof Akre, Anders Widmark, Freddie Hamdy, Markus Graefen, Stefan Carlsson, Gunnar Steineck, N Peter Wiklund
BACKGROUND: There is increasing low-quality evidence rationalizing the use of radical therapy for men at high risk of disseminated prostate cancer. OBJECTIVE: To investigate, using high-quality epidemiologic data, whether initial radical therapy in men at high risk of disseminated prostate cancer improves survival. DESIGN, SETTING, AND PARTICIPANTS: An observational population-based Swedish study from 1996 to 2010 of men at high risk of disseminated prostate cancer (prostate-specific antigen [PSA] >50) initially treated by radical therapy (radiation therapy [n=630] or radical prostatectomy [n=120]) or androgen deprivation therapy (n=17 602), and followed for up to 15 yr...
April 14, 2017: European Urology
https://www.readbyqxmd.com/read/28415613/promoter-dna-methylation-analysis-reveals-a-combined-diagnosis-of-cpg-based-biomarker-for-prostate-cancer
#12
Yuanyuan Tang, Shusuan Jiang, Yinmin Gu, Weidong Li, Zengnan Mo, Yuanjie Huang, Tianyu Li, Yanling Hu
BACKGROUND: Prostate cancer (PCa) is the most common tumor in elderly men. However, the specificity and sensitivity of serum prostate-specific antigen levels in PCa diagnosis are controversial. This study aims to reveal a novel diagnosis biomarker in PCa. MATERIALS AND METHODS: The differential methylated CpG sites between 423 primary PCa and 39 adjacent samples from The Cancer Genome Atlas (TCGA) on Illumina HumanMethylation 450 platform were analyzed. The diagnostic methylation markers were mined using the Prediction Analysis of Microarrays package in Bioconductor...
March 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28413378/is-age-an-independent-factor-for-prostate-cancer-a-paired-analysis
#13
José Arnaldo Shiomi da Cruz, Carlo C Passerotti, Sabrina Thalita Dos Reis, Mary Ellen Salles Guariero, Olimpio Daniel de Campos, Katia Ramos Moreira Leite, Miguel Srougi
INTRODUCTION: Prostate cancer is the most prevalent malignant neoplasia among men worldwide. Several prognostic factors, including Gleason's score, the measurement of serum prostate-specific antigen (PSA) and the evaluation of the percentage of fragments affected by cancer on prostate biopsy, have already been established. Age alone, however, has yet to be studied as a prognostic factor independently from other known factors. The aim of the present study was to compare the characteristics and the evolution of prostate cancer in different age groups using a paired analysis for patients with equivalent known prognostic factors...
January 2017: Current Urology
https://www.readbyqxmd.com/read/28412658/cds-mn-quantum-dot-functionalized-g-c3n4-nanohybrids-as-signal-generation-tags-for-photoelectrochemical-immunoassay-of-prostate-specific-antigen-coupling-dnazyme-concatamer-with-enzymatic-biocatalytic-precipitation
#14
Kangyao Zhang, Shuzhen Lv, Zhenzhen Lin, Dianping Tang
A new photoelectrochemical (PEC) immunosensor based on Mn-doped CdS quantum dots (CdS:Mn QDs) on g-C3N4 nanosheets was developed for the sensitive detection of prostate specific antibody (PSA) in biological fluids. The signal derived from the as-synthesized Cd:Mn QDs-functionalized g-C3N4 nanohybrids via a hydrothermal method and was amplified through DNAzyme concatamers on gold nanoparticles accompanying enzymatic biocatalytic precipitation. Experimental results by UV-vis absorption spectra and photoluminescence revealed that CdS:Mn QDs/g-C3N4 nanohybrids exhibited higher photocurrent than those of CdS:Mn QDs and g-C3N4 alone...
April 12, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28412653/the-relationship-between-dioxins-exposure-and-risk-of-prostate-cancer-with-steroid-hormone-and-age-in-vietnamese-men
#15
Xian Liang Sun, Teruhiko Kido, Seijiro Honma, Eitetsu Koh, Rie Okamoto, Ho Dung Manh, Shoko Maruzeni, Muneko Nishijo, Hideaki Nakagawa, Takeshi Nakano, Takumi Takasuga, Dang Duc Nhu, Nguyen Ngoc Hung, Le Ke Son
Although Vietnam's massive herbicide exposure in 1960s and 1970s was clearly injurious to health, not all causal relationships have been clarified. We therefore explored associations among dioxins, steroid hormones, age and prostate cancer risk in men. We compared serum levels of dioxin, steroid hormones and prostate specific antigen (PSA) in men aged 56-81years from herbicide-exposed hotspots (n=50) with those from non-sprayed regions (n=48). Mean serum levels of dioxin congeners in the hotspot group were 1...
April 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28412251/c-myc-antagonises-the-transcriptional-activity-of-the-androgen-receptor-in-prostate-cancer-affecting-key-gene-networks
#16
Stefan J Barfeld, Alfonso Urbanucci, Harri M Itkonen, Ladan Fazli, Jessica L Hicks, Bernd Thiede, Paul S Rennie, Srinivasan Yegnasubramanian, Angelo M DeMarzo, Ian G Mills
Prostate cancer (PCa) is the most common non-cutaneous cancer in men. The androgen receptor (AR), a ligand-activated transcription factor, constitutes the main drug target for advanced cases of the disease. However, a variety of other transcription factors and signaling networks have been shown to be altered in patients and to influence AR activity. Amongst these, the oncogenic transcription factor c-Myc has been studied extensively in multiple malignancies and elevated protein levels of c-Myc are commonly observed in PCa...
April 5, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28412062/development-and-internal-validation-of-a-novel-model-to-identify-the-candidates-for-extended-pelvic-lymph-node-dissection-in-prostate-cancer
#17
Giorgio Gandaglia, Nicola Fossati, Emanuele Zaffuto, Marco Bandini, Paolo Dell'Oglio, Carlo Andrea Bravi, Giuseppe Fallara, Francesco Pellegrino, Luigi Nocera, Pierre I Karakiewicz, Zhe Tian, Massimo Freschi, Rodolfo Montironi, Francesco Montorsi, Alberto Briganti
BACKGROUND: Preoperative assessment of the risk of lymph node invasion (LNI) is mandatory to identify prostate cancer (PCa) patients who should receive an extended pelvic lymph node dissection (ePLND). OBJECTIVE: To update a nomogram predicting LNI in contemporary PCa patients with detailed biopsy reports. DESIGN, SETTING, AND PARTICIPANTS: Overall, 681 patients with detailed biopsy information, evaluated by a high-volume uropathologist, treated with radical prostatectomy and ePLND between 2011 and 2016 were identified...
April 12, 2017: European Urology
https://www.readbyqxmd.com/read/28410986/predictors-of-biochemical-recurrence-after-primary-focal-cryosurgery-hemiablation-for-localized-prostate-cancer-a-multi-institutional-analytic-comparison-of-phoenix-and-stuttgart-criteria
#18
Michael Kongnyuy, Michael J Lipsky, Shahidul Islam, Dennis J Robins, Shaun Hager, Daniel M Halpern, Kaitlin E Kosinski, Jeffrey T Schiff, Anthony T Corcoran, Sven Wenske, Aaron E Katz
BACKGROUND: The Phoenix definition (PD) and Stuttgart definition (SD) designed to determine biochemical recurrence (BCR) in patients with postradiotherapy and high-intensity focused ultrasound organ-confined prostate cancer are being applied to follow patients after cryosurgery. We sought to identify predictors of BCR using the PD and SD criteria in patients who underwent primary focal cryosurgery (PFC). MATERIALS AND METHODS: We performed a retrospective review of patients who underwent PFC (hemiablation) at 2 referral centers from 2000 to 2014...
April 11, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28409907/the-roles-of-prostate-specific-antigen-psa-density-prostate-volume-and-their-zone-adjusted-derivatives-in-predicting-prostate-cancer-in-patients-with-psa-less-than-20-0%C3%A2-ng-ml
#19
P Shen, J Zhao, G Sun, N Chen, X Zhang, H Gui, Y Yang, J Liu, K Shu, Z Wang, H Zeng
The aim of this study was to develop nomograms for predicting prostate cancer and its zonal location using prostate-specific antigen density, prostate volume, and their zone-adjusted derivatives. A total of 928 consecutive patients with prostate-specific antigen (PSA) less than 20.0 ng/mL, who underwent transrectal ultrasound-guided transperineal 12-core prostate biopsy at West China Hospital between 2011 and 2014, were retrospectively enrolled. The patients were randomly split into training cohort (70%, n = 650) and validation cohort (30%, n = 278)...
May 2017: Andrology
https://www.readbyqxmd.com/read/28409402/clinical-evaluation-of-tamsulosin-in-the-relief-of-lower-urinary-tract-symptoms-in-advanced-prostate-cancer-patients
#20
Tong Zhang, Haihu Wu, Shuai Liu, Wei He, Kejia Ding
PURPOSE: To assess the effectiveness and safety of tamsulosin combined with androgen deprivation therapy (ADT) for lower urinary tract symptoms (LUTS) in advanced prostate cancer (PC) patients. METHODS: Ninety PC patients with moderate-to-severe LUTS randomized into two groups of 45 each. One group received ADT (group 1), and the other received ADT plus tamsulosin (group 2) for 24 weeks. The outcome measures were changes in the International Prostate Symptom Score (IPSS), IPSS obstructive and irritative subscores, quality of life (QoL), maximum urinary flow rate (Q max), post-voiding residual (PVR) and prostate-specific antigen (PSA) from baseline...
April 13, 2017: International Urology and Nephrology
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