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Prostatic specific antigen

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https://www.readbyqxmd.com/read/29028767/prostate-specific-membrane-antigen-guided-salvage-lymph-node-dissection-in-recurrent-prostate-cancer-a-novel-technology-to-detect-lymph-node-metastases
#1
Tobias Maurer, Jürgen E Gschwend, Matthias Eiber
PURPOSE OF REVIEW: With Gallium (Ga)-prostate-specific membrane antigen (PSMA) PET/computed tomography (CT) as emerging imaging technique offering superior detection rates in biochemical recurrent prostate cancer, salvage lymph node dissection has gained increasing interest in localized oligometastatic prostate cancer. Currently, PSMA-targeting small molecules cannot only be linked to positron-emitting isotopes for imaging but also be labelled with γ-radiation emitting isotopes. These modified PSMA agents are evaluated for intraoperative guidance for resection of metastatic lymph nodes...
October 11, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/29028765/preventing-clinical-progression-and-need-for-treatment-in-patients-on-active-surveillance-for-prostate-cancer
#2
Hanan Goldberg, Zachary Klaassen, Thenappan Chandrasekar, Neil Fleshner
PURPOSE OF REVIEW: Active surveillance is an established treatment option for men with localized, low-risk prostate cancer (CaP). It entails the postponement of immediate therapy with the option of delayed intervention upon disease progression. The rate of clinical progression and need for treatment on active surveillance is approximately 50% over 15 years. The present review summarizes recent data on current methods, attempting to prevent clinical progression. RECENT FINDINGS: Patient selection for active surveillance is the first mandatory step required to lower progression...
October 11, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/29028294/carbon-dots-g-c3n4-nanoheterostructures-based-signal-generation-tags-for-photoelectrochemical-immunoassay-of-cancer-biomarkers-coupling-with-copper-nanoclusters
#3
Shuzhen Lv, Yi Li, Kangyao Zhang, Zhenzhen Lin, Dianping Tang
A class of 0-dimensional/2-dimensional (0D/2D) nanoheterostructures based on carbon quantum dots (CQDs) and graphitic carbon nitride (g-C3N4) was designed as the signal-generation tags for the sensitive photoelectrochemical (PEC) immunoassay of prostate-specific antigen (PSA) coupling with the copper nanoclusters (CuNCs). Combination of CQDs with g-C3N4 promoted the photoexcited electron/hole separation, and largely increased the photocurrents of the nanoheterostructures. Initially, a sandwich-type immunoreaction was carried out on monoclonal anti-PSA antibody-coated microplate by using PSA aptamer linked with CuNCs as the tracer...
October 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29028078/a-natural-pharma-standard-supplement-formulation-to-control-treatment-related-toxicity-and-oxidative-stress-in-genitourinary-cancer-a-preliminary-study
#4
A Ledda, G Belcaro, M Dugall, R Luzzi, M Hosoi, B Feragalli, R Cotellese, V Cosentino, M Cosentino, R Eggenhoffner, M Pellizzato, A Fratter, L Giacomelli
OBJECTIVE: Oncological treatments are associated with toxicities that may decrease compliance to treatment in most genitourinary cancer patients. Supplementation with pharmaceutical-standardized supplement may be a supplementary method to control the side effects after chemo- and radiotherapy and the increased oxidative stress associated to treatments. This registry study evaluated a natural combination of supplements containing curcumin, cordyceps, and astaxanthin (Oncotris™) used as supplementary management in genitourinary cancer patients who had undergone oncological therapy...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29026946/psma-targeted-radioligandtherapy-in-metastatic-castration-resistant-prostate-cancer-after-chemotherapy-abiraterone-and-or-enzalutamide-a-retrospective-analysis-of-overall-survival
#5
K Rahbar, M Boegemann, A Yordanova, M Eveslage, M Schäfers, M Essler, H Ahmadzadehfar
AIM: Our aim was to evaluate overall survival and parameters prognosticating longer survival in a large and homogeneous group of patients treated with (177)Lu-PSMA-617 radioligand therapy with heavily pretreated advanced metastatic castration resistant prostate cancer. METHODS: A total of 104 patients were treated with 351 cycles of (177)Lu-PSMA-617. Prostate specific antigen (PSA) changes after the first cycle of therapy were documented prior to a second cycle...
October 12, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29026057/pathological-outcome-for-chinese-patients-with-low-risk-prostate-cancer-eligible-for-active-surveillance-and-undergoing-radical-prostatectomy-comparison-of-six-different-active-surveillance-protocols
#6
C F Tsang, J Hl Tsu, T Ct Lai, K W Wong, B Sh Ho, A Tl Ng, W K Ma, M K Yiu
INTRODUCTION: Active surveillance is one of the therapeutic options for the management of patients with low-risk prostate cancer. This study compared the performance of six different active surveillance protocols for prostate cancer in the Chinese population. METHODS: Patients who underwent radical prostatectomy for prostate cancer from January 1998 to December 2012 at a university teaching hospital in Hong Kong were reviewed. Six active surveillance protocols were applied to the cohort...
October 13, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/29025989/low-level-endogenous-prostate-specific-membrane-antigen-psma-expression-in-non-prostatic-tumor-xenografts-is-sufficient-for-in-vivo-tumor-targeting-and-imaging
#7
Sridhar Nimmagadda, Mrudula Pullambhatla, Ying Chen, Princy Parsana, Ala Lisok, Samit Chatterjee, Ronnie Mease, Steven P Rowe, Shawn E Lupold, Kenneth J Pienta, Martin G Pomper
Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer and within the neovasculature of other solid tumors. The non-prostatic expression of PSMA has been reported exclusively within the neovasculature endothelial cells of non-prostate cancers, however, there are few reports on PSMA expression on epithelial cells. Herein we describe PSMA expression in non-prostatic epithelial cells and characterize the potential of PSMA-binding agents to non-invasively detect that expression. METHODS: PSMA expression data was extracted from publicly available genomic databases...
October 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29025845/a-multicentre-randomised-controlled-trial-assessing-whether-mri-targeted-biopsy-is-non-inferior-to-standard-transrectal-ultrasound-guided-biopsy-for-the-diagnosis-of-clinically-significant-prostate-cancer-in-men-without-prior-biopsy-a-study-protocol
#8
Veeru Kasivisvanathan, Fatima Jichi, Laurence Klotz, Arnauld Villers, Samir S Taneja, Shonit Punwani, Alex Freeman, Mark Emberton, Caroline M Moore
INTRODUCTION: The classical pathway for the diagnosis of prostate cancer is transrectal ultrasound-guided (TRUS) biopsy of the prostate initiated on the basis of a raised prostate-specific antigen (PSA). An alternative pathway is to perform multi-parametricMRI (MPMRI) to localise cancer and to use this information to influence the decision for, and conduct of, a subsequent biopsy, known as an MPMRI-targeted biopsy. An MPMRI pathway has been shown to detect a similar or greater amount of clinically significant cancer as TRUS biopsy but has several advantages, including the potential to biopsy fewer men with fewer cores...
October 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29025456/a-finger-or-not-prostate-examinations-by-non-urologists-at-a-south-african-academic-institution
#9
Kalli Spencer
BACKGROUND: According to the South African (SA) National Cancer Registry 2009, prostate cancer is the most commonly diagnosed solid-organ cancer in SA men: the incidence increases at ~3% every year, with 1/26 men developing prostate cancer in their lifetime and five men dying every day. Screening for prostate cancer by performing a digital rectal examination (DRE) adds to the sensitivity and specificity of serum prostate-specific antigen (PSA) testing and is an important component of the assessment for the early detection of prostate cancer...
June 30, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29023685/summary-statement-on-screening-for-prostate-cancer-in-europe
#10
Eveline A M Heijnsdijk, Chris H Bangma, Josep M Borràs, Tiago M de Carvalho, Xavier Castells, Martin Eklund, Josep A Espinàs, Markus Graefen, Henrik Grönberg, Iris Lansdorp-Vogelaar, Pim J van Leeuwen, Vera Nelen, Franz Recker, Monique J Roobol, Pieter Vandenbulcke, Harry J de Koning
The European Randomised Study of Screening for Prostate Cancer (ERSPC) showed that Prostate-Specific Antigen (PSA) based screening results in a significant prostate cancer mortality reduction. Although there are concerns on overdiagnosis and overtreatment, it has been shown that the benefits can outweigh the harms if screening is stopped in older ages to prevent overdiagnosis. A limited screening program (for example screening at ages 55-59 years), including active surveillance for men with low-risk tumors, can even be cost-saving, compared with testing in an opportunistic setting in the wrong ages, as currently in Europe...
October 12, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29023514/prostate-cancer-screening-knowledge-attitudes-and-practices-in-a-sample-of-men-in-italy-a-survey
#11
Marianna Morlando, Concetta Paola Pelullo, Gabriella Di Giuseppe
BACKGROUND: The aim of this study was to evaluate the knowledge, attitudes and behaviors towards prostate cancer and its prevention. METHODS: A cross-sectional survey was conducted on a random sample of 625 fathers of students attending eight public schools. The self-administered questionnaire included questions on: socio-demographic characteristics, personal and familiar medical history of prostate cancer, knowledge about prostate cancer and the prostate-specific antigen (PSA) test, perception of risk towards prostate cancer, perception of the benefits of having a PSA-test, willingness to receive the PSA-test and sources of and needs of information regarding prostate cancer and the PSA-test...
2017: PloS One
https://www.readbyqxmd.com/read/29022058/-psma-radioguided-surgery-in-localised-recurrent-prostate-cancer
#12
REVIEW
T Horn, I Rauscher, M Eiber, J E Gschwend, T Maurer
Recently, prostate-specific membrane antigen radioguided surgery (PSMA-RGS) was introduced for targeted resection of localised prostate cancer recurrence. Preliminary results show that PSMA-RGS is very sensitive and specific in tracking suspicious lesions intraoperatively. Prerequisite for PSMA-RGS is a positive (68)Ga-PSMA positron emission tomography (PET) scan with a preferably singular soft tissue or lymph node recurrence. The first 63 patients treated with PSMA-RGS were analyzed. The extracorporal analysis of a total of 277 tissue specimens yielded the following test quality criteria regarding the presence of malignant tissue: sensitivity 86...
October 11, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29017493/enzalutamide-versus-abiraterone-as-a-first-line-endocrine-therapy-for-castration-resistant-prostate-cancer-enable-study-for-pca-a-study-protocol-for-a-multicenter-randomized-phase-iii-trial
#13
Kouji Izumi, Atsushi Mizokami, Mikio Namiki, Shogo Inoue, Nobumichi Tanaka, Yuko Yoshio, Kei Ishibashi, Manabu Kamiyama, Noriyasu Kawai, Hideki Enokida, Takashi Shima, Shizuko Takahara
BACKGROUND: Both enzalutamide and abiraterone have demonstrated improved radiographic progression-free and overall survival for castration-resistant prostate cancer (CRPC) compared with placebo controls before docetaxel treatment in phase III studies. These oral agents target androgen and androgen receptor signaling and are thought to be less toxic than chemotherapy. Cross-resistance to these agents was recently reported because of their similar mechanism of action, and it is important to assess which agent is more effective to use initially for CRPC...
October 10, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28993510/genomic-gain-of-16p13-3-in-prostate-cancer-predicts-poor-clinical-outcome-after-surgical-intervention
#14
Yogesh M Bramhecha, Karl-Philippe L Guérard, Shaghayegh Rouzbeh, Eleonora M Scarlata, Fadi Brimo, Simone M A Chevalier, Lucie Hamel, Alice Dragomir, Armen Aprikian, Jacques Lapointe
Identifying tumors with high metastatic potential is key to improving the clinical management of prostate cancer (PCa). Recently, we characterized a chromosome 16p13.3 gain frequently observed in PCa metastases and now demonstrate the prognostic value of this genomic alteration in surgically treated PCa. Dual-color fluorescence in situ hybridization (FISH) was used to detect 16p13.3 gain on a human tissue microarray (TMA) representing 304 primary radical prostatectomy (RP) cases with clinical follow-up data...
October 9, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28992664/-clinical-study-on-the-efficacy-and-continuous-docetaxel-based-chemotherapy-treatment-for-castration-resistant-prostate-cancer
#15
Ippei Chikazawa, Shinya Inoue, Yusuke Nakazawa, Dan Nakai, Nobuyo Morita, Tatsuro Tanaka, Yoshiharu Motoo, Katsuhito Miyazawa
We report a retrospective study on the efficacy, adverse events and the factors for continuous docetaxel (DOC) therapy for patients with castration-resistant prostate cancer (CRPC). Between April 2007 and April 2015, 37 CRPC patients were treated with DOC therapy at Kanazawa Medical University Hospital. DOC was administered every 3 weeks at 70 mg/m2. Prostatic specific antigen (PSA) level, adverse events, cycles of DOC therapy, survival time and clinical passage were examined. Fifteen patients showed a decrease in PSA level of 50% or more, 9 patients showed less than 50% decrease in PSA level and 13 patients showed no decrease in PSA level...
September 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28991765/effects-of-serenoa-repens-alcohol-extract-on-benign-prostate-hyperplasia
#16
Skender Saidi, Sotir Stavridis, Oliver Stankov, Sasho Dohcev, Sasho Panov
An increasing tendency has recently emerged for the use of phytotherapeutic agents as alternative to commercial pharmacological agents for the treatment of benign prostate hyperplasia (BPH). The purpose of this study is to evaluate the effects of Serenoa repens alcohol extract treatment on BPH patients' symptoms and major parameters during one-year follow-up. The study was performed on 70 men aged 40 - 79 years (mean 60.58) with symptomatic BPH that were divided into a group of 40 patients treated with Serenoa repens extract (SRT) and a control group of 30 patients that received no treatment and were observed only...
September 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/28991234/dhx15-promotes-prostate-cancer-progression-by-stimulating-siah2-mediated-ubiquitination-of-androgen-receptor
#17
Y Jing, M M Nguyen, D Wang, L E Pascal, W Guo, Y Xu, J Ai, F-M Deng, K Z Masoodi, X Yu, J Zhang, J B Nelson, S Xia, Z Wang
Androgen receptor (AR) activation is critical for prostate cancer (PCa) development and progression, including castration resistance. The nuclear export signal of AR (NES(AR)) has an important role in AR intracellular trafficking and proteasome-dependent degradation. Here, we identified the RNA helicase DHX15 as a novel AR co-activator using a yeast mutagenesis screen and revealed that DHX15 regulates AR activity by modulating E3 ligase Siah2-mediated AR ubiquitination independent of its ATPase activity. DHX15 and Siah2 form a complex with AR, through NES(AR)...
October 9, 2017: Oncogene
https://www.readbyqxmd.com/read/28990601/direct-sensing-of-cancer-biomarkers-in-clinical-samples-with-a-designed-nanopore
#18
Yao Lin, Yi-Lun Ying, Xin Shi, Shao-Chuang Liu, Yi-Tao Long
Here, we show a designed solid-state nanopore sensor for the direct sensing and quantification of prostate-specific antigen (PSA) as cancer biomarker in serum without any pretreatment. This nanopore technique provides a convenient, fast, and low-cost quantification of cancer biomarkers in clinical samples.
October 9, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28989573/corn-silk-extract-improves-benign-prostatic-hyperplasia-in-experimental-rat-model
#19
So Ra Kim, Ae Wha Ha, Hyun Ji Choi, Sun Lim Kim, Hyeon Jung Kang, Myung Hwan Kim, Woo Kyoung Kim
BACKGROUND/OBJECTIVES: This study was conducted to investigate the effect of a corn silk extract on improving benign prostatic hyperplasia (BPH). MATERIALS/METHODS: The experimental animals, 6-week-old male Wistar rats, were divided into sham-operated control (Sham) and experimental groups. The experimental group, which underwent orchiectomy and received subcutaneous injection of 10 mg/kg of testosterone propionate to induce BPH, was divided into a Testo Only group that received only testosterone, a Testo+Fina group that received testosterone and 5 mg/kg finasteride, a Testo+CSE10 group that received testosterone and 10 mg/kg of corn silk extract, and a Testo+CSE100 group that received testosterone and 100 mg/kg of corn silk extract...
October 2017: Nutrition Research and Practice
https://www.readbyqxmd.com/read/28988695/temporal-trends-in-clinical-and-pathological-characteristics-for-men-undergoing-radical-prostatectomy-between-1995-and-2013-at-rigshospitalet-copenhagen-denmark-and-stanford-university-hospital-united-states
#20
Mathias Dyrberg Loft, Kasper Drimer Berg, Andreas Kjaer, Peter Iversen, Michelle Ferrari, Chiyuan A Zhang, Klaus Brasso, James D Brooks, Martin Andreas Røder
PURPOSE: To analyze how prostate-specific antigen (PSA) screening and practice patterns has affected trends in tumor characteristics in men undergoing radical prostatectomy (RP) in the United States and Denmark. Unlike in the United States, PSA screening has not been recommended in Denmark. PATIENTS AND METHODS: We performed an observational register study using pre- and postoperative data on 2168 Danish patients from Rigshospitalet, Copenhagen, Denmark, and 2236 patients from Stanford University Hospital, Stanford, CA, who underwent RP between 1995 and 2013...
September 6, 2017: Clinical Genitourinary Cancer
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