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https://www.readbyqxmd.com/read/28223962/molecular-mechanisms-in-mood-regulation-involving-the-circadian-clock
#1
REVIEW
Urs Albrecht
The circadian system coordinates activities and functions in cells and tissues in order to optimize body functions in anticipation to daily changes in the environment. Disruption of the circadian system, due to irregular lifestyle such as rotating shift work, frequent travel across time-zones, or chronic stress, is correlated with several diseases such as obesity, cancer, and neurological disorders. Molecular mechanisms linking the circadian clock with neurological functions have been uncovered suggesting that disruption of the clock may be critically involved in the development of mood disorders...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28214594/association-between-light-at-night-melatonin-secretion-sleep-deprivation-and-the-internal-clock-health-impacts-and-mechanisms-of-circadian-disruption
#2
REVIEW
Yvan Touitou, Alain Reinberg, David Touitou
Exposure to Artificial Light At Night (ALAN) results in a disruption of the circadian system, which is deleterious to health. In industrialized countries, 75% of the total workforce is estimated to have been involved in shift work and night work. Epidemiologic studies, mainly of nurses, have revealed an association between sustained night work and a 50-100% higher incidence of breast cancer.The potential and multifactorial mechanisms of the effects include the suppression of melatonin secretion by ALAN, sleep deprivation, and circadian disruption...
February 15, 2017: Life Sciences
https://www.readbyqxmd.com/read/28203201/modulation-of-synaptic-plasticity-in-the-cortex-needs-to-understand-all-the-players
#3
REVIEW
Claire N J Meunier, Pascal Chameau, Philippe M Fossier
The prefrontal cortex (PFC) is involved in cognitive tasks such as working memory, decision making, risk assessment and regulation of attention. These functions performed by the PFC are supposed to rely on rhythmic electrical activity generated by neuronal network oscillations determined by a precise balance between excitation and inhibition balance (E/I balance) resulting from the coordinated activities of recurrent excitation and feedback and feedforward inhibition. Functional alterations in PFC functions have been associated with cognitive deficits in several pathologies such as major depression, anxiety and schizophrenia...
2017: Frontiers in Synaptic Neuroscience
https://www.readbyqxmd.com/read/28198811/%C3%AE-thalassemia-patients-revealed-a-significant-change-of-untargeted-metabolites-in-comparison-to-healthy-individuals
#4
Syed Ghulam Musharraf, Ayesha Iqbal, Saqib Hussain Ansari, Sadia Parveen, Ishtiaq Ahmad Khan, Amna Jabbar Siddiqui
β-Thalassemia is one of the most prevalent forms of congenital blood disorders characterized by reduced hemoglobin levels with severe complications, affecting all dimensions of life. The mechanisms underlying the phenotypic heterogeneity of β-thalassemia are still poorly understood. We aimed to work over metabolite biomarkers to improve mechanistic understanding of phenotypic heterogeneity and hence better management of disorder at different levels. Untargeted serum metabolites were analyzed after protein precipitation and SPE (solid phase extraction) from 100 β-thalassemia patients and 61 healthy controls using GC-MS...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28195660/facilitators-and-barriers-to-the-adoption-of-ergonomic-solutions-in-construction
#5
Ann Marie Dale, Lisa Jaegers, Laura Welch, Ellen Barnidge, Nancy Weaver, Bradley A Evanoff
BACKGROUND: Rates of musculoskeletal disorders in construction remain high. Few studies have described barriers and facilitators to the use of available ergonomic solutions. This paper describes these barriers and facilitators and their relationship to the level of adoption. METHODS: Three analysts rated 16 proposed ergonomic solutions from a participatory ergonomics study and assessed the level of adoption, six adoption characteristics, and identified the category of adoption from a theoretical model...
March 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28182562/in-silico-modeling-of-the-functional-role-of-reduced-sialylation-in-sodium-and-potassium-channel-gating-of-mouse-ventricular-myocytes
#6
Dongping Du, Hui Yang, Andrew R Ednie, Eric S Bennett
Cardiac ion channels are highly glycosylated membrane proteins, with up to 30% of the protein's mass containing glycans. Heart diseases often accompany individuals with congenital disorders of glycosylation (CDG). However, cardiac dysfunction among CDG patients is not yet fully understood. There is an urgent need to study how aberrant glycosylation impacts cardiac electrical signaling. Our previous works reported that congenitally reduced sialylation achieved through deletion of the sialyltransferase gene, ST3Gal4, leads to altered gating of voltage-gated Na+ and K+ channels (Nav and Kv, respectively)...
February 6, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28173798/spasmogenic-and-spasmolytic-activity-of-rind-of-punica-granatum-linn
#7
Niaz Ali, Ayesha Jamil, Syed Wadood Ali Shah, Ismail Shah, Ghayour Ahmed
BACKGROUND: Rind of Punica granatum is traditionally used in treatment of abdominal cramps and various GIT disorders. So far spasmolytic activity of rind of Punica granatum has been reported using in vitro model. However, its mode of action is not explored yet. Therefore, the current work describes the possible mode of action for spasmolytic activity of methanolic extract of rind of Punica granatum (Pg. Cr). Acute toxicity study is also performed to determine its safe dose range. METHODS: Rind of Punica granatum was subjected to shade drying...
February 7, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28167329/the-role-of-set-shifting-in-auditory-verbal-hallucinations
#8
Sara Siddi, Donatella Rita Petretto, Caterina Burrai, Rosanna Scanu, Antonella Baita, Pierfranco Trincas, Emanuela Trogu, Liliana Campus, Augusto Contu, Antonio Preti
BACKGROUND: Auditory verbal hallucinations (AVHs) are a cardinal characteristic of psychosis. Recent research on the neuropsychological mechanism of AVHs has focused on source monitoring failure, but a few studies have suggested the involvement of attention, working memory, processing speed, verbal learning, memory, and executive functions. In this study we examined the neuropsychological profile of patients with AVHs, assuming that the mechanism underlying this symptom could be a dysfunction of specific cognitive domains...
January 21, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28167115/association-between-autistic-traits-and-emotion-adaptation-to-partially-occluded-faces
#9
Chengwen Luo, Edwin Burns, Hong Xu
Prolonged exposure to a happy face makes subsequently presented faces appear sadder: the facial emotion aftereffect (FEA). People with autism spectrum disorders and their relatives have diminished holistic perception of faces. Levels of autism can be measured continuously in the general population by autistic traits using the autism-quotient (AQ). Prior work has not found any association between AQ and FEA in adults, possibly due to non-holistic processing strategies employed by those at the higher end of the spectrum...
February 16, 2017: Vision Research
https://www.readbyqxmd.com/read/28157094/treadmill-exercise-exerts-neuroprotection-and-regulates-microglial-polarization-and-oxidative-stress-in-a-streptozotocin-induced-rat-model-of-sporadic-alzheimer-s-disease
#10
Yujiao Lu, Yan Dong, Donovan Tucker, Ruimin Wang, Mohammad Ejaz Ahmed, Darrell Brann, Quanguang Zhang
Recent work has suggested that exercise may be beneficial in preventing or ameliorating symptoms of several neurological disorders, although the mechanism is not entirely understood. The current study was designed to examine the potential beneficial effect of treadmill exercise upon cognitive function in a streptozotocin (STZ)-induced rat model of Alzheimer's disease (AD). Animals underwent treadmill exercise (30 min/day, 5 days/week) for 4 weeks after bilateral STZ intracerebroventricular injection (2.4 mg/kg)...
February 1, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28141715/-when-the-prescription-pad-is-not-enough-attention-deficit-hyperactivity-disorder-management-2-0
#11
Jenny Radesky, Arathi Reddy, Naomi Steiner, Marilyn Augustyn
Jose is a 13-year-old boy who presents to his primary care provider after struggling in school for many years. When he was in the first grade, he was diagnosed at a tertiary center with attention-deficit hyperactivity disorder. Multiple medication trials have produced few benefits and many side effects including poor sleep, morbid thoughts, lack of motivation, and, according to his parents, "he seemed like a robot."He comes now for his annual physical in April, and the parents tell you that the school is threatening that he be retained in the seventh grade...
February 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28134670/noninvasive-prenatal-diagnosis-for-single-gene-disorders
#12
Stephanie Allen, Elizabeth Young, Benjamin Bowns
PURPOSE OF REVIEW: Noninvasive prenatal diagnosis for single gene disorders is coming to fruition in its clinical utility. The presence of cell-free DNA in maternal plasma has been recognized for many years, and a number of applications have developed from this. Noninvasive prenatal diagnosis for single gene disorders has lagged behind due to complexities of technology development, lack of investment and the need for validation samples for rare disorders. RECENT FINDINGS: Publications are emerging demonstrating a variety of technical approaches and feasibility of clinical application...
January 27, 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28128961/unravelling-the-roles-of-size-ligands-and-pressure-in-the-piezochromic-properties-of-cds-nanocrystals
#13
Niccolò R C Corsini, Nicholas D M Hine, Peter D Haynes, Carla Molteni
Understanding the effects of pressure-induced deformations on the optoelectronic properties of nanomaterials is important not only from the fundamental point of view but also for potential applications such as stress sensors and electromechanical devices. Here, we describe the novel insights into these piezochromic effects gained from using a linear-scaling density functional theory framework and an electronic enthalpy scheme, which allow us to accurately characterize the electronic structure of CdS nanocrystals with a zincblende-like core of experimentally relevant size...
January 27, 2017: Nano Letters
https://www.readbyqxmd.com/read/28124702/excitation-wavelength-dependent-fluorescence-of-graphene-oxide-controlled-by-strain
#14
Scott K Cushing, Weiqiang Ding, Gang Chen, Chao Wang, Feng Yang, Fuqiang Huang, Nianqiang Wu
Unlike conventional fluorophores, the fluorescence emission of graphene oxide (GO) sheets can shift hundreds of nanometers as the excitation wavelength increases. The excitation wavelength dependent fluorescence is referred to as a giant red-edge effect and originates in a local reorganization potential slowing down the solvation dynamics of the excited state to the same time scale as the fluorescence lifetime. The present work has discovered that out-of-plane strain in the graphene oxide sheet leads to the intra-layer interaction necessary to slow down the solvation time scale...
January 26, 2017: Nanoscale
https://www.readbyqxmd.com/read/28120439/multiple-helical-conformations-of-the-helix-turn-helix-region-revealed-by-noe-restrained-md-simulations-of-tryptophan-aporepressor-trpr
#15
Balasubramanian Harish, G V T Swapna, Gregory J Kornhaber, Gaetano T Montelione, Jannette Carey
The nature of flexibility in the helix-turn-helix region of E. coli trp aporepressor has been unexplained for many years. The original ensemble of NMR structures showed apparent disorder, but chemical shift and relaxation measurements indicated a helical region. NOE data for a temperature-sensitive mutant showed more helical character in its helix-turn-helix region, but nevertheless also led to an apparently disordered ensemble. However, conventional NMR structure determination methods require all structures in the ensemble to be consistent with every NOE simultaneously...
January 25, 2017: Proteins
https://www.readbyqxmd.com/read/28088873/developmental-changes-in-ultradian-sleep-cycles-across-early-childhood
#16
Sean Lopp, William Navidi, Peter Achermann, Monique LeBourgeois, Cecilia Diniz Behn
Nocturnal human sleep is composed of cycles between rapid eye movement (REM) sleep and non-REM (NREM) sleep. In adults, the structure of ultradian cycles between NREM and REM sleep is well characterized; however, less is known about the developmental trajectories of ultradian sleep cycles across early childhood. Cross-sectional studies indicate that the rapid ultradian cycling of active-quiet sleep in infancy shifts to a more adult-like pattern of NREM-REM sleep cycling by the school-age years, yet longitudinal studies elucidating the details of this transition are scarce...
January 1, 2017: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/28052315/deficits-in-temporal-processing-correlate-with-clinical-progression-in-huntington-s-disease
#17
P V Agostino, E M Gatto, M Cesarini, J L Etcheverry, A Sanguinetti, D A Golombek
OBJECTIVES: Precise temporal performance is crucial for several complex tasks. Time estimation in the second-to-minutes range-known as interval timing-involves the interaction of the basal ganglia and the prefrontal cortex via dopaminergic-glutamatergic pathways. Patients with Huntington's disease (HD) present deficits in cognitive and motor functions that require fine control of temporal processing. The objective of the present work was to assess temporal cognition through a peak-interval time (PI) production task in patients with HD and its potential correlation with the Unified Huntington's Disease Rating Scale (UHDRS)...
January 3, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28012806/shift-work-and-shift-work-sleep-disorder-clinical-and-organizational-perspectives
#18
REVIEW
Emerson M Wickwire, Jeanne Geiger-Brown, Steven M Scharf, Christopher L Drake
Throughout the industrialized world, nearly one in five employees works some form of non-traditional shift. Such shift work is associated with numerous negative health consequences, ranging from cognitive complaints to cancer, as well as diminished quality of life. Further, a substantial percentage of shift workers develop shift work disorder (SWD), a circadian rhythm sleep disorder characterized by excessive sleepiness, insomnia, or both as a result of shift work. In addition to adverse health consequences and diminished quality of life at the individual level, SWD incurs significant costs to employers through diminished workplace performance and increased accidents and errors...
December 21, 2016: Chest
https://www.readbyqxmd.com/read/27995253/the-correlations-of-the-electronic-structure-and-film-growth-of-2-7-diocty-1-benzothieno-3-2-b-benzothiophene-c8-btbt-on-sio2
#19
Lu Lyu, Dongmei Niu, Haipeng Xie, Yuan Zhao, Ningtong Cao, Hong Zhang, Yuhe Zhang, Peng Liu, Yongli Gao
Combining ultraviolet photoemission spectroscopy (UPS), X-ray photoemission spectroscopy (XPS), atomic force microscopy (AFM) and small angle X-ray diffraction (SAXD) measurements, we perform a systematic investigation on the correlations of the electronic structure, film growth and molecular orientation of 2,7-diocty[1]benzothieno[3,2-b]benzothiophene (C8-BTBT) on silicon oxide (SiO2). AFM analysis reveals a phase transition of disorderedly oriented molecules in clusters in thinner films to highly ordered standing-up molecules in islands in thicker films...
January 4, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27994004/biological-aging-and-the-future-of-geriatric-psychiatry
#20
REVIEW
Bret R Rutherford, Warren D Taylor, Patrick J Brown, Joel R Sneed, Steven P Roose
Advances in understanding the biological bases of aging have intellectually revitalized the field of geriatric psychiatry and broadened its scope to include promoting successful aging and studying resilience factors in older adults. To describe the process by which this paradigm shift has occurred and illustrate its implications for treatment and research of late-life brain disorders, late-life depression is discussed as a prototype case. Prior phases of geriatric psychiatry research were focused on achieving depressive symptom relief, outlining pharmacokinetic and pharmacodynamic differences between older and younger adults, and identifying moderators of treatment response...
December 18, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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