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https://www.readbyqxmd.com/read/27924149/differences-in-real-world-executive-function-between-children-with-pediatric-bipolar-disorder-and-children-with-adhd
#1
Alessandra M Passarotti, Nidhi Trivedi, Liza Dominguez-Colman, Manharkumar Patel, Scott A Langenecker
BACKGROUND: Recent research evidence suggests that executive function (EF) is impaired in both pediatric bipolar disorder (PBD) and attention deficit-hyperactivity disorder (ADHD), although the underlying cognitive mechanisms are still unclear. In this study we examined EF, including cognitive and emotional control, in three pediatric groups with overlapping symptoms. METHODS: Sixteen children and adolescents with PBD, 17 children and adolescents with ADHD, Type Combined, and 13 children and adolescents with PBD and comorbid ADHD (PBD+ADHD) (mean age=12...
2016: Journal of the Canadian Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27895414/hepatic-encephalopathy-ever-closer-to-its-big-bang
#2
EDITORIAL
Pablo A Souto, Ariel R Marcotegui, Lisandro Orbea, Juan Skerl, Juan Carlos Perazzo
Hepatic encephalopathy (HE) is a neuropsychiatric disorder that commonly complicates the course of patients with liver disease. Despite the fact that the syndrome was probably first recognized hundreds of years ago, the exact pathogenesis still remains unclear. Minimal hepatic encephalopathy (MHE) is the earliest form of HE and is estimated to affect more that 75% of patients with liver cirrhosis. It is characterized by cognitive impairment predominantly attention, reactiveness and integrative function with very subtle clinical manifestations...
November 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27890116/forms-of-work-organization-and-associations-with-shoulder-disorders-results-from-a-french-working-population
#3
Julie Bodin, Ronan Garlantézec, Nathalie Costet, Alexis Descatha, Natacha Fouquet, Sandrine Caroly, Yves Roquelaure
The aim of this study was to identify forms of work organization in a French region and to study associations with the occurrence of symptomatic and clinically diagnosed shoulder disorders in workers. Workers were randomly included in this cross-sectional study from 2002 to 2005. Sixteen organizational variables were assessed by a self-administered questionnaire: i.e. shift work, job rotation, repetitiveness of tasks, paced work/automatic rate, work pace dependent on quantified targets, permanent controls or surveillance, colleagues' work and customer demand, and eight variables measuring decision latitude...
March 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/27884917/managing-barriers-to-empathy-in-the-clinical-encounter-a-qualitative-interview-study-with-gps
#4
Frans Awm Derksen, Tim C Olde Hartman, Jozien M Bensing, Antoine Lm Lagro-Janssen
BACKGROUND: Current daily general practice has become increasingly technical and somatically oriented (where attention to patients' feelings is decreased) due to an increase in protocol-based guidelines. Priorities in GP-patient communication have shifted from a focus on listening and empathy to task-oriented communication. AIM: To explore what barriers GPs experience when applying empathy in daily practice, and how these barriers are managed. DESIGN AND SETTING: Thirty Dutch GPs with sufficient heterogeneity in sex, age, type of practice, and rural or urban setting were interviewed...
December 2016: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/27869284/phase-separation-and-coexistence-of-hydrodynamically-interacting-microswimmers
#5
Johannes Blaschke, Maurice Maurer, Karthik Menon, Andreas Zöttl, Holger Stark
A striking feature of the collective behavior of spherical microswimmers is that for sufficiently strong self-propulsion they phase-separate into a dense cluster coexisting with a low-density disordered surrounding. Extending our previous work, we use the squirmer as a model swimmer and the particle-based simulation method of multi-particle collision dynamics to explore the influence of hydrodynamics on their phase behavior in a quasi-two-dimensional geometry. The coarsening dynamics towards the phase-separated state is diffusive in an intermediate time regime followed by a final ballistic compactification of the dense cluster...
November 21, 2016: Soft Matter
https://www.readbyqxmd.com/read/27824780/an-introduction-from-the-new-psychotherapy-columnist
#6
Eric M Plakun
Despite psychiatry's shift toward a biomedical model, emerging research suggests that psychosocial factors make major contributions to the etiology of mental disorders of all kinds and that several types of psychotherapy have been shown to be effective forms of treatment for a range of disorders. Notwithstanding these findings, psychiatrists are doing less psychotherapy and attending less to psychosocial factors in their work with patients. The author surveys some of the underpinnings of this problem and discusses the value of psychotherapy as part of psychiatric practice and training...
November 2016: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/27810939/night-shift-and-rotating-shift-in-association-with-sleep-problems-burnout-and-minor-mental-disorder-in-male-and-female-employees
#7
Wan-Ju Cheng, Yawen Cheng
OBJECTIVES: Shift work is associated with adverse physical and psychological health outcomes. However, the independent health effects of night work and rotating shift on workers' sleep and mental health risks and the potential gender differences have not been fully evaluated. METHODS: We used data from a nationwide survey of representative employees of Taiwan in 2013, consisting of 16 440 employees. Participants reported their work shift patterns 1 week prior to the survey, which were classified into the four following shift types: fixed day, rotating day, fixed night and rotating night shifts...
November 3, 2016: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27799519/piperine-s-mitigation-of-obesity-and-diabetes-can-be-explained-by-its-up-regulation-of-the-metabolic-rate-of-resting-muscle
#8
Leonardo Nogara, Nariman Naber, Edward Pate, Marcella Canton, Carlo Reggiani, Roger Cooke
We identify a target for treating obesity and type 2 diabetes, the consumption of calories by an increase in the metabolic rate of resting skeletal muscle. The metabolic rate of skeletal muscle can be increased by shifting myosin heads from the super-relaxed state (SRX), with a low ATPase activity, to a disordered relaxed state (DRX), with a higher ATPase activity. The shift of myosin heads was detected by a change in fluorescent intensity of a probe attached to the myosin regulatory light chain in skinned skeletal fibers, allowing us to perform a high-throughput screen of 2,128 compounds...
November 15, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27798222/predicting-cognition-and-psychosis-in-young-adults-with-22q11-2-deletion-syndrome
#9
Kevin M Antshel, Wanda Fremont, Seetha Ramanathan, Wendy R Kates
OBJECTIVE: To assess the extent to which the trajectories of intellectual, academic achievement, executive functioning, attention, working memory, and emotion recognition tests will be predictive of psychosis in young adults with 22q11.2 deletion syndrome (22q11DS). METHODS: Eighty-two participants with 22q11DS were assessed for psychiatric disorders and neuropsychological functioning with validated instruments. Siblings and community controls were employed as comparison groups...
October 25, 2016: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/27793075/does-modafinil-improve-the-level-of-consciousness-for-people-with-a-prolonged-disorder-of-consciousness-a-retrospective-pilot-study
#10
Samira Kashinath Dhamapurkar, Barbara A Wilson, Anita Rose, Peter Watson, Agnes Shiel
BACKGROUND AND AIM: Modafinil is best known as a sleep regulator among healthy individuals, but studies suggest that it reduces excessive daytime sleepiness in patients with brain injury. This retrospective pilot study evaluated the effectiveness of Modafinil for people with a prolonged disorder of consciousness and whether those with a traumatic brain injury did better than those with a non-traumatic brain injury. METHOD: Twenty four prolonged disorder of consciousness patients who were prescribed Modafinil, were assessed at least four times both before and during treatment...
October 28, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27792172/circadian-rhythm-shapes-the-gut-microbiota-affecting-host-radiosensitivity
#11
Ming Cui, Huiwen Xiao, Dan Luo, Xin Zhang, Shuyi Zhao, Qisheng Zheng, Yuan Li, Yu Zhao, Jiali Dong, Hang Li, Haichao Wang, Saijun Fan
Modern lifestyles, such as shift work, nocturnal social activities, and jet lag, disturb the circadian rhythm. The interaction between mammals and the co-evolved intestinal microbiota modulates host physiopathological processes. Radiotherapy is a cornerstone of modern management of malignancies; however, it was previously unknown whether circadian rhythm disorder impairs prognosis after radiotherapy. To investigate the effect of circadian rhythm on radiotherapy, C57BL/6 mice were housed in different dark/light cycles, and their intestinal bacterial compositions were compared using high throughput sequencing...
October 26, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27786471/membrane-insertion-of-a-dinuclear-polypyridylruthenium-ii-complex-revealed-by-solid-state-nmr-and-molecular-dynamics-simulation-implications-for-selective-antibacterial-activity
#12
Daniel K Weber, Marc-Antoine Sani, Matthew T Downton, Frances Separovic, F Richard Keene, J Grant Collins
Dinuclear polypyridylruthenium(II) complexes bridged by a flexible methylene linker have received considerable interest as potential antibacterial agents. Their potency and uptake into bacterial cells is directly modulated by the length of the bridging linker, which has implicated membrane interactions as an essential feature of their mechanism of action. In this work, a combination of molecular dynamics (MD) simulations and solid-state NMR was used to present an atomistic model of a polypyridylruthenium(II) complex bound and incorporated into a bacterial membrane model...
October 27, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27785533/who-is-going-to-rescue-the-rescuers-post-traumatic-stress-disorder-among-rescue-workers-operating-in-greece-during-the-european-refugee-crisis
#13
Dimitra Sifaki-Pistolla, Vasiliki-Eirini Chatzea, Sofia-Aikaterini Vlachaki, Evangelos Melidoniotis, Georgia Pistolla
PURPOSE: During the European refugee crisis, numerous Greek and international rescue workers are operating in Lesvos, offering search, rescue, and first aid services. Exposure to stressful life events while engaging in this rescue work can result in developing Post-Traumatic Stress Disorder (PTSD). The study aimed to assess the prevalence of PTSD and explore potential differences between different categories of rescuers. METHODS: A cross-sectional study was conducted among 217 rescue workers...
October 26, 2016: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/27780126/analyzing-raman-infrared-spectral-correlation-in-the-recently-found-meteorite-cs%C3%A3-talja
#14
A Kereszturi, I Gyollai, Zs Kereszty, K Kiss, M Szabó, Z Szalai, M Ringer, M Veres
Correlating the Raman and infrared spectra of shocked minerals in Csátalja ordinary chondrite (H4, S2, W2) with controlling the composition by EPMA measurements, we identified and improved various shock indicators, as infrared spectro-microscopic analysis has been poorly used for shock impact alteration studies of meteorites to date. We also provide reference spectra as SOM for the community with local mineralogical and shock alteration related context to support further standardization of the IR ATR based measurements...
October 18, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/27755061/lassbio-1422-a-new-molecular-scaffold-with-efficacy-in-animal-models-of-schizophrenia-and-disorders-of-attention-and-cognition
#15
Andresa H Betti, Camila B Antonio, Thais E T Pompeu, Thaise S Martins, Vivian Herzfeldt, Eveline D Stolz, Carlos A M Fraga, Eliezer Barreiro, François Noël, Stela M K Rates
Aiming to identify new antipsychotic lead-compounds, our group has been working on the design and synthesis of new N-phenylpiperazine derivatives. Here, we characterized LASSBio-1422 as a pharmacological prototype of this chemical series. Adult male Wistar rats and CF1 mice were used for in-vitro and in-vivo assays, respectively. LASSBio-1422 [1 and 5 mg/kg, postoperatively (p.o.)] inhibited apomorphine-induced climbing as well as ketamine-induced hyperlocomotion (1 and 5 mg/kg, p.o.), animal models predictive of efficacy on positive symptoms...
October 13, 2016: Behavioural Pharmacology
https://www.readbyqxmd.com/read/27752325/computer-use-at-work-is-associated-with-self-reported-depressive-and-anxiety-disorder
#16
Taeshik Kim, Mo-Yeol Kang, Min-Sang Yoo, Dongwook Lee, Yun-Chul Hong
BACKGROUND: With the development of technology, extensive use of computers in the workplace is prevalent and increases efficiency. However, computer users are facing new harmful working conditions with high workloads and longer hours. This study aimed to investigate the association between computer use at work and self-reported depressive and anxiety disorder (DAD) in a nationally representative sample of South Korean workers. METHODS: This cross-sectional study was based on the third Korean Working Conditions Survey (2011), and 48,850 workers were analyzed...
2016: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27751955/intercriteria-analysis-of-calorimetric-data-of-blood-serum-proteome
#17
Sashka Krumova, Svetla Todinova, Deyan Mavrov, Pencho Marinov, Vassia Atanassova, Krassimir Atanassov, Stefka G Taneva
BACKGROUND: Biological microcalorimetry has entered into a phase where its potential for disease diagnostics is readily recognized. A wide variety of oncological and immunological disorders have been characterized by differential scanning calorimetry (DSC) and characteristic thermodynamic profiles were reported. Now the challenge before DSC is not the experimental data collection but the development of analysis protocols for reliable data stratification/classification and discrimination of disease specific features (calorimetric markers)...
October 15, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27738956/bayesian-approach-for-addressing-differential-covariate-measurement-error-in-propensity-score-methods
#18
Hwanhee Hong, Kara E Rudolph, Elizabeth A Stuart
Propensity score methods are an important tool to help reduce confounding in non-experimental studies and produce more accurate causal effect estimates. Most propensity score methods assume that covariates are measured without error. However, covariates are often measured with error. Recent work has shown that ignoring such error could lead to bias in treatment effect estimates. In this paper, we consider an additional complication: that of differential measurement error across treatment groups, such as can occur if a covariate is measured differently in the treatment and control groups...
October 13, 2016: Psychometrika
https://www.readbyqxmd.com/read/27712985/-quality-of-professional-life-and-musculoskeletal-disorders-in-nurses
#19
Lilia Rodarte-Cuevas, Roxana Araujo-Espino, Perla María Trejo-Ortiz, José González-Tovar
OBJECTIVE: To characterize the conditions of quality of working life, the presence of muscle- skeletal disorders and the association between these variables in nursing staff of a public hospital in Zacatecas, Mexico. METHOD: A cross-sectional study with descriptive-correlational scope was designed. A stratified random sampling per shift was used in 107 cases. The Questionnaire Professional Quality of Life (CVP-35) was applied as well as the Nordic Questionnaire Standardized for musculoskeletal pain and work-related risk factors questionnaire...
October 3, 2016: Enfermería Clínica
https://www.readbyqxmd.com/read/27692049/randomized-prospective-study-of-the-impact-of-a-sleep-health-program-on-firefighter-injury-and-disability
#20
Jason P Sullivan, Conor S O'Brien, Laura K Barger, Shantha M W Rajaratnam, Charles A Czeisler, Steven W Lockley
STUDY OBJECTIVES: Firefighters' schedules include extended shifts and long work weeks which cause sleep deficiency and circadian rhythm disruption. Many firefighters also suffer from undiagnosed sleep disorders, exacerbating fatigue. We tested the hypothesis that a workplace-based Sleep Health Program (SHP) incorporating sleep health education and sleep disorders screening would improve firefighter health and safety compared to standard practice. DESIGN: Prospective station-level randomized, field-based intervention...
September 26, 2016: Sleep
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