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https://www.readbyqxmd.com/read/28538024/effects-of-vilazodone-on-suicidal-ideation-and-behavior-in-adults-with-major-depressive-disorder-or-generalized-anxiety-disorder-post-hoc-analysis-of-randomized-double-blind-placebo-controlled-trials
#1
Michael E Thase, John Edwards, Suresh Durgam, Changzheng Chen, Cheng-Tao Chang, Maju Mathews, Carl P Gommoll
Treatment-emergent suicidal ideation and behavior are ongoing concerns with antidepressants. Vilazodone, currently approved for the treatment of major depressive disorder (MDD) in adults, has also been evaluated in generalized anxiety disorder (GAD). Post-hoc analyses of vilazodone trials were carried out to examine its effects on suicidal ideation and behavior in adults with MDD or GAD. Data were pooled from vilazodone trials in MDD (four studies) and GAD (three studies). The incidence of suicide-related events was analyzed on the basis of treatment-emergent adverse event reporting and Columbia-Suicide Severity Rating Scale (C-SSRS) monitoring...
May 19, 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28536575/inflammatory-long-pentraxin-3-is-associated-with-leukocyte-telomere-length-in-night-shift-workers
#2
Sofia Pavanello, Mariarita Stendardo, Giuseppe Mastrangelo, Melissa Bonci, Barbara Bottazzi, Manuela Campisi, Marco Nardini, Roberto Leone, Alberto Mantovani, Piera Boschetto
Aging is an emerging worldwide threat to public health, even in the workplace, as it links with risk of illness and death. Bewildered inflammatory responses and stressful conditions associate with age-related disorders. Additionally, circadian rhythm disruption, a critical health issue in night-shift workers, correlates with premature aging. We investigated the hypothesis of a link between altered inflammatory response, detected by plasmatic long pentraxin 3 (PTX3), and biological aging, measured by leukocyte telomere length (LTL), attrition, and possibly induced by night-shift work...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28533170/synchronizing-effects-of-melatonin-on-diurnal-and-circadian-rhythms
#3
REVIEW
Martina Pfeffer, Horst-Werner Korf, Helmut Wicht
In mammals, the rhythmic secretion of melatonin from the pineal gland is driven by the circadian clock in the suprachiasmatic nucleus (SCN) of the hypothalamus. The robust nightly peak of melatonin secretion is an output signal of the circadian clock and is supposed to deliver the circadian message to the whole of the organism. Since the circadian system regulates many behavioral and physiological processes, its disruption by external (shift-work, jet-lag) or internal desynchronization (blindness, aging) causes many different health problems...
May 19, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28531352/conformational-complexity-in-the-lh2-antenna-of-the-purple-sulfur-bacterium-allochromatium-vinosum-revealed-by-hole-burning-spectroscopy
#4
Adam Kell, Mahboobe Jassas, Khem Acharya, Kirsty Hacking, Richard J Cogdell, Ryszard J Jankowiak
This work discusses the protein conformational complexity of the B800-850 LH2 complexes from the purple sulfur bacterium Allochromatium vinosum, focusing on the spectral characteristics of the B850 chromophores. Low-temperature B850 absorption and the split B800 band shift blue and red, respectively, at elevated temperatures, revealing isosbestic points. The latter indicates the presence of two (unresolved) conformations of B850 bacteriochlorophylls (BChls), referred to as conformations 1 and 2, and two conformations of B800 BChls, denoted as B800R and B800B...
May 22, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28502261/profiles-of-executive-function-across-children-with-distinct-brain-disorders-traumatic-brain-injury-stroke-and-brain-tumor
#5
Gabriel C Araujo, Tanya N Antonini, Vicki Anderson, Kathryn A Vannatta, Christina G Salley, Erin D Bigler, H Gerry Taylor, Cynthia Gerhardt, Kenneth Rubin, Maureen Dennis, Warren Lo, Mark T Mackay, Anne Gordon, Christine Hajek Koterba, Alison Gomes, Mardee Greenham, Keith Owen Yeates
OBJECTIVES: This study examined whether children with distinct brain disorders show different profiles of strengths and weaknesses in executive functions, and differ from children without brain disorder. METHODS: Participants were children with traumatic brain injury (N=82; 8-13 years of age), arterial ischemic stroke (N=36; 6-16 years of age), and brain tumor (N=74; 9-18 years of age), each with a corresponding matched comparison group consisting of children with orthopedic injury (N=61), asthma (N=15), and classmates without medical illness (N=68), respectively...
May 15, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28501741/executive-functioning-deficits-among-adults-with-bipolar-disorder-types-i-and-ii-a-systematic-review-and-meta-analysis
#6
REVIEW
Tania Dickinson, Rodrigo Becerra, Jacqui Coombes
BACKGROUND: Executive functioning (EF) deficits contribute to a significant proportion of the burden of disease associated with bipolar disorder (BD). Yet, there is still debate in the literature regarding the exact profile of executive functioning in BD. The purpose of the present project was to assess whether EF deficits exist among adults suffering BD, and whether these deficits (if apparent) differ by BD subtype. METHODS: A systematic search identified relevant literature...
April 29, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28450138/test-retest-reliability-of-prefrontal-transcranial-direct-current-stimulation-tdcs-effects-on-functional-mri-connectivity-in-healthy-subjects
#7
Jana Wörsching, Frank Padberg, Konstantin Helbich, Alkomiet Hasan, Lena Koch, Stephan Goerigk, Sophia Stoecklein, Birgit Ertl-Wagner, Daniel Keeser
Transcranial Direct Current Stimulation (tDCS) of the prefrontal cortex (PFC) can be used for probing functional brain connectivity and meets general interest as novel therapeutic intervention in psychiatric and neurological disorders. Along with a more extensive use, it is important to understand the interplay between neural systems and stimulation protocols requiring basic methodological work. Here, we examined the test-retest (TRT) characteristics of tDCS-induced modulations in resting-state functional-connectivity MRI (RS fcMRI)...
April 24, 2017: NeuroImage
https://www.readbyqxmd.com/read/28445790/improving-insomnia-in-primary-care-patients-a-randomized-controlled-trial-of-nurse-led-group-treatment
#8
Christina Sandlund, Jerker Hetta, Gunnar H Nilsson, Mirjam Ekstedt, Jeanette Westman
BACKGROUND: Insomnia is a common health problem, and most people who seek help for insomnia consult primary care. In primary care, insomnia treatment typically consists of hypnotic drugs, although cognitive behavioral therapy for insomnia is the recommended treatment. However, such treatment is currently available to few primary care patients. OBJECTIVES: To evaluate the effects of a group treatment program for insomnia led by nurses in primary care. OUTCOMES: were the Insomnia Severity Index, a 2-week sleep diary, and a questionnaire on frequency of hypnotic drug use...
April 14, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28444732/low-back-pain-among-nurses-in-slovenian-hospitals-cross-sectional-study
#9
B Skela-Savič, K Pesjak, S Hvalič-Touzery
AIM: The study investigated the prevalence and factors predicting low back pain among nurses in Slovenian hospitals. BACKGROUND: The risk factors for low back pain are physical and psychosocial. Implementation of interventions for reducing low back pain calls for management support, accessible equipment, education, knowledge and risk assessment. INTRODUCTION: Low back pain prevalence and incidence among healthcare workers is very high compared to the general population and is a strong risk factor for long-term sickness absence...
April 26, 2017: International Nursing Review
https://www.readbyqxmd.com/read/28438276/integrating-yoga-into-psychotherapy-the-ethics-of-moving-from-the-mind-to-the-mat
#10
Jaclyn M Kamradt
Given the rise in attention to client preferences in medical treatment and the shift in focus toward health promotion, it is not surprising that the use of complementary health approaches have increased in the past several years. Yoga is among the most prominent complementary health approaches. Recently, both qualitative and quantitative work has emerged supporting its use for a variety of medical and psychological disorders. However, there is a critical gap in knowledge regarding how to most optimally and ethically integrate complementary therapies (i...
May 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/28426908/clinically-useful-brain-imaging-for-neuropsychiatry-how-can-we-get-there
#11
REVIEW
Michael P Milham, R Cameron Craddock, Arno Klein
Despite decades of research, visions of transforming neuropsychiatry through the development of brain imaging-based "growth charts" or "lab tests" have remained out of reach. In recent years, there is renewed enthusiasm about the prospect of achieving clinically useful tools capable of aiding the diagnosis and management of neuropsychiatric disorders. The present work explores the basis for this enthusiasm. We assert that there is no single advance that currently has the potential to drive the field of clinical brain imaging forward...
April 20, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28425730/the-relation-of-anxiety-and-cognition-in-parkinson-s-disease
#12
Gretchen O Reynolds, Kristine K Hanna, Sandy Neargarder, Alice Cronin-Golomb
OBJECTIVE: Parkinson's disease (PD) has long been conceptualized as a motor disorder, but nonmotor symptoms also manifest in the disease and significantly reduce quality of life. Anxiety and cognitive dysfunction are prevalent nonmotor symptoms, even in early disease stages, but the relation between these symptoms remains poorly understood. We examined self-reported anxiety and neurocognitive function, indexed by measures of executive function (set-shifting and phonemic fluency), categorical fluency, and attention/working memory...
April 20, 2017: Neuropsychology
https://www.readbyqxmd.com/read/28419474/using-advances-from-cognitive-behavioral-models-of-anxiety-to-guide-treatment-for-social-anxiety-disorder
#13
Rachel K Narr, Bethany A Teachman
This case features an adult male with moderate social anxiety disorder and mild depressive symptoms who showed an initial positive response to an earlier experience of cognitive behavior therapy, but then relapsed when he started avoiding social situations again because of continuing beliefs that experiencing anxiety was unacceptable. His treatment at our clinic focused on shifting unhelpful thinking about the likelihood and consequences of becoming anxious and reengaging in avoided social situations so he could learn to tolerate negative affect and uncertainty...
May 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28409765/effects-of-patient-handling-and-individual-factors-on-the-prevalence-of-low-back-pain-among-nursing-personnel
#14
Seyed Ehsan Samaei, Maryam Mostafaee, Hasanali Jafarpoor, Majid Bagheri Hosseinabadi
BACKGROUND: Patient-handling is one of the main tasks of nursing personnel; it imposes compressive and shear forces on nurses' lower spine. The aim of this study was to determine the prevalence of Low Back Pain (LBP), risk factors in the incidence of such disorders, and patient handling risk assessment among nursing personnel. METHODS: This study was carried out on 243 randomly selected nursing personnel who played a role in handling the patients (58 wards). Patient Transfer Assessment Instrument (PTAI) checklists alongside Standardized Nordic Musculoskeletal Questionnaires (NMQ) were used for data collection...
2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28408897/do-executive-functions-predict-binge-drinking-patterns-evidence-from-a-longitudinal-study-in-young-adulthood
#15
Ragnhild Bø, Joël Billieux, Line C Gjerde, Espen M Eilertsen, Nils I Landrø
Background: Impairments in executive functions (EFs) are related to binge drinking in young adulthood, but research on how EFs influence future binge drinking is lacking. The aim of the current report is therefore to investigate the association between various EFs and later severity of, and change in, binge drinking over a prolonged period during young adulthood. Methods: At baseline, 121 students reported on their alcohol habits (Alcohol use disorder identification test; Alcohol use questionnaire). Concurrently, EFs [working memory, reversal, set-shifting, response inhibition, response monitoring and decision-making (with ambiguity and implicit risk)] were assessed...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28375611/phase-transition-dielectric-properties-and-ionic-transport-in-the-ch3-2nh2-pbi3-organic-inorganic-hybrid-with-2h-hexagonal-perovskite-structure
#16
A García-Fernández, J M Bermúdez-García, S Castro-García, A L Llamas-Saiz, R Artiaga, J López-Beceiro, S Hu, W Ren, A Stroppa, M Sánchez-Andújar, M A Señarís-Rodríguez
In this work, we focus on [(CH3)2NH2]PbI3, a member of the [AmineH]PbI3 series of hybrid organic-inorganic compounds, reporting a very easy mechanosynthesis route for its preparation at room temperature. We report that this [(CH3)2NH2]PbI3 compound with 2H-perovskite structure experiences a first-order transition at ≈250 K from hexagonal symmetry P63/mmc (HT phase) to monoclinic symmetry P21/c (LT phase), which involves two cooperative processes: an off-center shift of the Pb(2+) cations and an order-disorder process of the N atoms of the DMA cations...
April 4, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28370106/the-negative-impact-of-prison-work-on-sleep-health
#17
Lois James, Natalie Todak, Suzanne Best
OBJECTIVES: To examine the prevalence of sleep disorders, deprivation, and quality in a sample of prison employees, and investigate the relationship between exposure to work-related critical incidents and sleep. METHODS: We surveyed 355 Washington State Department of Corrections employees. The survey included the Pittsburg Sleep Quality Index and the Critical Incident History Questionnaire. RESULTS: We found 28% and 45% of the sample reported suffering from Apnea and insomnia, respectively...
March 30, 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28364446/randomized-prospective-study-of-the-impact-of-a-sleep-health-program-on-firefighter-injury-and-disability
#18
Jason P Sullivan, Conor S O'Brien, Laura K Barger, Shantha M W Rajaratnam, Charles A Czeisler, Steven W Lockley
Study Objectives: Firefighters' schedules include extended shifts and long work weeks which cause sleep deficiency and circadian rhythm disruption. Many firefighters also suffer from undiagnosed sleep disorders, exacerbating fatigue. We tested the hypothesis that a workplace-based Sleep Health Program (SHP) incorporating sleep health education and sleep disorders screening would improve firefighter health and safety compared to standard practice. Design: Prospective station-level randomized, field-based intervention...
January 1, 2017: Sleep
https://www.readbyqxmd.com/read/28362369/monovalent-cation-doping-of-ch3nh3pbi3-for-efficient-perovskite-solar-cells
#19
Mojtaba Abdi-Jalebi, M Ibrahim Dar, Aditya Sadhanala, Satyaprasad P Senanayak, Michael Grätzel, Richard H Friend
Here, we demonstrate the incorporation of monovalent cation additives into CH3NH3PbI3 perovskite in order to adjust the optical, excitonic, and electrical properties. The possibility of doping was investigated by adding monovalent cation halides with similar ionic radii to Pb(2+), including Cu(+), Na(+), and Ag(+). A shift in the Fermi level and a remarkable decrease of sub-bandgap optical absorption, along with a lower energetic disorder in the perovskite, was achieved. An order-of-magnitude enhancement in the bulk hole mobility and a significant reduction of transport activation energy within an additive-based perovskite device was attained...
March 19, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28361338/maternal-executive-functioning-and-scaffolding-in-families-of-children-with-and-without-parent-reported-adhd
#20
Heather Mazursky-Horowitz, Sharon R Thomas, Kelsey E Woods, Jeffrey S Chrabaszcz, Kirby Deater-Deckard, Andrea Chronis-Tuscano
Parental scaffolding robustly predicts child developmental outcomes, including improved self-regulation and peer relationships and fewer externalizing behaviors. However, few studies have examined parental characteristics associated with a parent's ability to scaffold. Executive functioning (EF) may be an important individual difference factor associated with maternal scaffolding that has yet to be examined empirically. Scaffolding may be particularly important for children with attention-deficit/hyperactivity disorder (ADHD) and disruptive behavior disorder (DBD) symptoms due to their core difficulties with inattention, disorganization, EF, and self-regulation, their need for greater parental structure, and higher-than-average rates of parental EF deficits...
March 30, 2017: Journal of Abnormal Child Psychology
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