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Shift work disorder

Andresa H Betti, Camila B Antonio, Thais E T Pompeu, Thaise S Martins, Vivian Herzfeldt, Eveline D Stolz, Carlos A M Fraga, Eliezer Barreiro, François Noël, Stela M K Rates
Aiming to identify new antipsychotic lead-compounds, our group has been working on the design and synthesis of new N-phenylpiperazine derivatives. Here, we characterized LASSBio-1422 as a pharmacological prototype of this chemical series. Adult male Wistar rats and CF1 mice were used for in-vitro and in-vivo assays, respectively. LASSBio-1422 [1 and 5 mg/kg, postoperatively (p.o.)] inhibited apomorphine-induced climbing as well as ketamine-induced hyperlocomotion (1 and 5 mg/kg, p.o.), animal models predictive of efficacy on positive symptoms...
October 13, 2016: Behavioural Pharmacology
Taeshik Kim, Mo-Yeol Kang, Min-Sang Yoo, Dongwook Lee, Yun-Chul Hong
BACKGROUND: With the development of technology, extensive use of computers in the workplace is prevalent and increases efficiency. However, computer users are facing new harmful working conditions with high workloads and longer hours. This study aimed to investigate the association between computer use at work and self-reported depressive and anxiety disorder (DAD) in a nationally representative sample of South Korean workers. METHODS: This cross-sectional study was based on the third Korean Working Conditions Survey (2011), and 48,850 workers were analyzed...
2016: Annals of Occupational and Environmental Medicine
Sashka Krumova, Svetla Todinova, Deyan Mavrov, Pencho Marinov, Vassia Atanassova, Krassimir Atanassov, Stefka G Taneva
BACKGROUND: Biological microcalorimetry has entered into a phase where its potential for disease diagnostics is readily recognized. A wide variety of oncological and immunological disorders have been characterized by differential scanning calorimetry (DSC) and characteristic thermodynamic profiles were reported. Now the challenge before DSC is not the experimental data collection but the development of analysis protocols for reliable data stratification/classification and discrimination of disease specific features (calorimetric markers)...
October 15, 2016: Biochimica et Biophysica Acta
Hwanhee Hong, Kara E Rudolph, Elizabeth A Stuart
Propensity score methods are an important tool to help reduce confounding in non-experimental studies and produce more accurate causal effect estimates. Most propensity score methods assume that covariates are measured without error. However, covariates are often measured with error. Recent work has shown that ignoring such error could lead to bias in treatment effect estimates. In this paper, we consider an additional complication: that of differential measurement error across treatment groups, such as can occur if a covariate is measured differently in the treatment and control groups...
October 13, 2016: Psychometrika
Lilia Rodarte-Cuevas, Roxana Araujo-Espino, Perla María Trejo-Ortiz, José González-Tovar
OBJECTIVE: To characterize the conditions of quality of working life, the presence of muscle- skeletal disorders and the association between these variables in nursing staff of a public hospital in Zacatecas, Mexico. METHOD: A cross-sectional study with descriptive-correlational scope was designed. A stratified random sampling per shift was used in 107 cases. The Questionnaire Professional Quality of Life (CVP-35) was applied as well as the Nordic Questionnaire Standardized for musculoskeletal pain and work-related risk factors questionnaire...
October 3, 2016: Enfermería Clínica
Jason P Sullivan, Conor S O'Brien, Laura K Barger, Shantha M W Rajaratnam, Charles A Czeisler, Steven W Lockley
STUDY OBJECTIVES: Firefighters' schedules include extended shifts and long work weeks which cause sleep deficiency and circadian rhythm disruption. Many firefighters also suffer from undiagnosed sleep disorders, exacerbating fatigue. We tested the hypothesis that a workplace-based Sleep Health Program (SHP) incorporating sleep health education and sleep disorders screening would improve firefighter health and safety compared to standard practice. DESIGN: Prospective station-level randomized, field-based intervention...
September 26, 2016: Sleep
Alex Cohen, Amit Dias, Fredric Azariah, Revathi N Krishna, Miriam Sequeira, Sherin Abraham, Pim Cuijpers, Jennifer Q Morse, Charles F Reynolds, Vikram Patel
OBJECTIVES: The population of India is aging rapidly. This demographic shift brings with it a host of challenges to the health and well-being of older adults, including the increased prevalence of non-communicable diseases, among them depressive disorders. In this paper, we report on qualitative research intended to inform the development of a locally acceptable and appropriate intervention to improve the well-being of older adults in Goa, India and, specifically, to prevent late-life depression...
September 30, 2016: Aging & Mental Health
Klaus Kessler, Jason J Braithwaite
INTRODUCTION: Hallucinations that involve shifts in the subjectively experienced location of the self, have been termed "out-of-body experiences" (OBEs). Early psychiatric accounts cast OBEs as a specific instance of depersonalisation and derealisation disorder (DPD-DR). However, during feelings of alienation and lack of body realism in DPD-DR the self is experienced within the physical body. Deliberate forms of "disembodiment" enable humans to imagine another's visuo-spatial perspective taking (VPT), thus, if a strong relationship between deliberate and spontaneous forms of disembodiment could be revealed, then uncontrolled OBEs could be "the other side of the coin" of a uniquely human capacity...
August 10, 2016: Cognitive Neuropsychiatry
Shashank Tandon, Kristen A Keefe, Sharif A Taha
Ethanol, like other drugs of abuse, has both rewarding and aversive properties. Previous work suggests that sensitivity to ethanol's aversive effects negatively modulates voluntary alcohol intake and thus may be important in vulnerability to developing alcohol use disorders. We previously found that rats with lesions of the lateral habenula (LHb), which is implicated in aversion-mediated learning, show accelerated escalation of voluntary ethanol consumption. To understand neural encoding in the LHb contributing to ethanol-induced aversion, we recorded neural firing in the LHb of freely behaving, water-deprived rats before and after an ethanol-induced (1...
September 28, 2016: Journal of Physiology
Niaz Ali, Robina Begum, Muhammad Saleh Faisal, Aslam Khan, Muhammad Nabi, Gulfam Shehzadi, Shakir Ullah, Waqar Ali
BACKGROUND: Statins are used for treatment of hypercholestremia. Common adverse reports associated with use of statins are generalized bodyache, rhabdomyolysis, muscles weakness and gastrointestinal disorders. The current work is an attempt to explain how smooth muscles of gastrointestinal tissues are affected by the current statins (Simvastatin, atorvastatin, fluvastatin and rosuvastatin). METHODS: Effects of the current statins were studied on spontaneous activity of isolated rabbits' jejunal preparations...
2016: BMC Pharmacology & Toxicology
Jake R Henkie, Paul A Rowntree
Adsorption of atomic and molecular species on several model film surfaces is shown to lead to systematic and reproducible spectral shifts for infrared absorption peaks associated with vibrations at the film/adsorbate interface. These shifts to lower frequencies are demonstrated to be versatile spectral signatures of this exposed interface. While this is found to occur for a wide variety of adsorbates, this work focuses on the adsorption of Xe onto molecular surfaces. By using the pre-Xe film reflectivity as a reference in calculating the spectra, the changes induced by Xe adsorption due to van der Waals forces are isolated from the conventional film spectrum which contains both surface and subsurface spectral contributions...
October 18, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Matthew C Morris, Natalie Hellman, James L Abelson, Uma Rao
Individuals with posttraumatic stress disorder (PTSD) typically exhibit altered hypothalamic-pituitary-adrenal (HPA) function and sympathetic nervous system (SNS) activity. The goals of this study were to determine whether HPA and SNS alterations in the immediate aftermath of trauma predict subsequent PTSD symptom development and whether inconsistencies observed between studies can be explained by key demographic and methodological factors. This work informs secondary prevention of PTSD by identifying subgroups of trauma survivors at risk for PTSD...
September 4, 2016: Clinical Psychology Review
Leanne Tamm, Sarah B Brenner, Morgan E Bamberger, Stephen P Becker
The aim of this study is to investigate whether sluggish cognitive tempo (SCT) symptoms are associated with neurocognitive task performance and ratings of real-world executive functioning (EF) in preschoolers at risk for attention-deficit/hyperactivity disorder (ADHD). The associations between parent- and teacher-rated SCT symptoms and neuropsychological task performance and ratings of EF in 61 4-year-old preschool children (51 boys, 10 girls) with self-regulation difficulties were examined, with regression analyses controlling for the effects of ADHD inattention symptoms...
September 13, 2016: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
A A Hussein, A A Hamidieh, A Elhaddad, M Ramzi, T B Othman, F Hussain, D Dennison, P Ahmed, M Abboud, A Al-Ahmari, A Wahadneh, J Fathy, M-A Bekadja, S Al-Kindi, S Benchekroun, A Ibrahim, M Behfar, M Samra, S Ladeb, S Adil, H El-Solh, M Ayas, M Aljurf, A Ghavamzadeh, A Al-Seraihy
To describe the hematopoietic stem cell transplantation (HSCT) activities for children in the Eastern Mediterranean (EM) region, data on transplants performed for children less than 18 years of age between 1984 and 2011 in eight EM countries (Egypt, Iran, Jordan, Lebanon, Oman, Pakistan, Saudi Arabia and Tunisia) were collected. A total of 5187 transplants were performed, of which 4513 (87%) were allogeneic and 674 (13%) were autologous. Overall, the indications for transplantation were malignant diseases in 1736 (38...
September 12, 2016: Bone Marrow Transplantation
Giampaolo Perna, Paolo Cavedini, Philip D Harvey, Nunzia Valentina Di Chiaro, Silvia Daccò, Daniela Caldirola
OBJECTIVE: We investigated the association between neuropsychological performance and real-life functioning in obsessive-compulsive disorder (OCD). As a secondary aim, we investigated the association between neuropsychological performance and self-reported quality of life (QoL). METHODS: We retrospectively selected 68 of 240 inpatients with OCD, who had been hospitalised for a 4-week psychiatric rehabilitation programme. We used clinical information recorded in the patients' electronic medical records...
November 2016: International Journal of Psychiatry in Clinical Practice
Danielle D Bosenbark, Lauren Krivitzky, Rebecca Ichord, Laura Jastrzab, Lori Billinghurst
Perinatal arterial ischemic stroke (PAIS) is a form of childhood stroke; the majority of those affected experience neurologic sequelae, including motor, language and neurocognitive impairments. This study examines the attention and executive functioning (EF) profiles of children following PAIS, as well as the impact of age and sex. In this single-center cross-sectional study, 40 children aged 3 to 16 years (median age 7.2 years; 58% male) who have suffered a PAIS underwent a comprehensive neuropsychological battery to assess attention and EF...
September 7, 2016: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
Shwn-Huey Shieh, Fung-Chang Sung, Chia-Hsien Su, Yafang Tsai, Vivian Chia-Rong Hsieh
OBJECTIVE: To examine whether the prevalence of low back pain (LBP) increased in hospital nurses with high patient care workload. MATERIALS AND METHODS: A structured, self-administered questionnaire was used to collect information on the prevalence of LBP and its associated factors from 788 registered nurses from a medical center in Taiwan. RESULTS: Among all nurses with eligible questionnaires, 567 (72.0%) had LBP. Mean daily hours of working, standing, and walking were persistently longer in the LBP group...
August 2016: Taiwanese Journal of Obstetrics & Gynecology
Koh Mizuno, Akiko Matsumoto, Tatsuya Aiba, Takashi Abe, Hiroshi Ohshima, Masaya Takahashi, Yuichi Inoue
BACKGROUND: Flight controllers of the International Space Station (ISS) are engaged in shift work to provide 24-h coverage to support ISS systems. The purpose of this study was to investigate the prevalence and associated factors of shift work sleep disorder (SWSD) among Japanese ISS flight controllers. METHODS: A questionnaire study was conducted using the Standard Shiftwork Index to evaluate sleep-related problems and possible associated variables. Among 52 respondents out of 73 flight controllers, 30 subjects were identified as night shift workers who worked 3 or more night shifts per month...
2016: Journal of Physiological Anthropology
Sarah L Bell, Jessica Tyrrell, Cassandra Phoenix
People's lived experiences of chronic illness have garnered increasing research interest over the last 30-40 years, with studies recognising the disruptive influence of illness onset and progression, both to people's everyday lives and to their biographical selves. We extend this body of work, drawing on the experiences of people living with Ménière's disease; a long-term progressive vestibular disorder characterised by unpredictable episodes of debilitating vertigo, tinnitus and permanent sensorineural hearing loss...
October 2016: Social Science & Medicine
Charli Sargent, Paul Roberts, Drew Dawson, Sally Ferguson, Lynn Meuleners, Libby Brook, Gregory D Roach
The 9th International Conference on Managing Fatigue in Transportation, Resources and Health was held in Fremantle, Western Australia in March 2015. The purpose of the conferences in this series is to provide a forum for industry representatives, regulators, and scientists to discuss recent advances in the field of fatigue research. We have produced a Special Issue of the International Journal of Environmental Research and Public Health based on papers from the conference that were focused on various aspects of public health...
2016: International Journal of Environmental Research and Public Health
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