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https://www.readbyqxmd.com/read/28746117/functional-gastrointestinal-disorders-common-among-nurses-with-poor-sleep-quality-in-shanghai-china-a-pilot-study
#1
Hui-Qing Zhou, Min Yao, Yuan-Wen Chen, Jia-Yi Huang, Guang-Yu Chen
This study aimed to determine whether functional gastrointestinal disorders are more common among nurses with self-reported poor sleep. In total, 468 nurses working the day shift or rotating shifts completed two questionnaires: the questionnaire for irritable bowel syndrome (IBS) using Rome III criteria and the Pittsburgh Sleep Quality Index (PSQI). The prevalence of poor sleep was 41.04% (95% confidence interval, CI: [36.23, 45.85]), and poor sleep was significantly more common among rotating-shift nurses than among day-shift nurses (50...
July 2017: Gastroenterology Nursing: the Official Journal of the Society of Gastroenterology Nurses and Associates
https://www.readbyqxmd.com/read/28738331/future-perspectives-in-sleep-medicine
#2
Leh-Kiong Anne Huon, Christian Guilleminault
"Sleep Medicine" is now a specialty in its own right. Currently, there is increasing recognition of the very negative impact sleep disorders have on learning, education, safety, and quality of life. Technological advances will help us to break down diagnoses (e.g., narcolepsy has now been subdivided into types 1 and 2, depending upon the hypocretin levels in the spinal fluid) and to discover relationships to other bodily systems (e.g., type 1 narcolepsy potentially being an autoimmune disorder). The modern lifestyle of many, as characterized by a shortening of sleep periods, shift work, jet lag, and the need to be constantly available, means that advances in sleep medicine may result in a major understanding of more balanced "work-rest lifestyle" modifications...
2017: Advances in Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28732185/chronotype-sleep-characteristics-and-musculoskeletal-disorders-among-hospital-nurses
#3
Yuan Zhang, Jeanne F Duffy, Elizabeth Ronan de Castillero, Kefang Wang
Work-related musculoskeletal disorders (WMSDs) persist as the leading occupational injury, accounting for nearly half of nurses' total occupational injuries. Musculoskeletal pain is a known cause of sleep disruption, and individuals with WMSDs that interfere with sleep often report more pain. Evening chronotype has been associated with poor sleep among nurses. However, the associations among chronotype, sleep, and WMSDs are still unclear, and were explored in the present study. A cross-sectional survey was administered to 397 nurses, with 47...
July 1, 2017: Workplace Health & Safety
https://www.readbyqxmd.com/read/28724029/-psychosocial-stress-at-work-and-alcohol-consumption-patterns-in-offshore-oil-workers
#4
Jahina Moura Vidal, Angela Mendes Abreu, Luciana Fernandes Portela
The objectives were to assess the association between psychosocial stress at work and alcohol consumption patterns in offshore oil workers. This was a cross-sectional study of 210 workers on offshore oil rigs in the state of Rio de Janeiro, Brazil, from July to September 2014. The data collection instrument was a self-completed multidimensional questionnaire. Exposure to stress was measured by the demand-control model and alcohol consumption pattern was measured with the Alcohol Use Disorders Identification Test (AUDIT)...
July 13, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28721811/moving-to-the-rhythm-with-clock-circadian-genes-autophagy-mtor-and-sirt1-in-degenerative-disease-and-cancer
#5
Kenneth Maiese
BACKGROUND: The mammalian circadian clock and its associated clock genes are increasingly be recognized as critical components for a number of physiological and disease processes that extend beyond hormone release, thermal regulation, and sleep-wake cycles. New evidence suggests that clinical behavior disruptions that involve prolonged shift work and even space travel may negatively impact circadian rhythm and lead to multi-system disease. METHODS: In light of the significant role circadian rhythm can hold over the body's normal physiology as well as disease processes, we examined and discussed the impact circadian rhythm and clock genes hold over lifespan, neurodegenerative disorders, and tumorigenesis...
July 17, 2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/28716545/effect-of-ageing-on-neurocognitive-function-by-stage-of-hiv-infection-evidence-from-the-multicenter-aids-cohort-study
#6
Karl Goodkin, Eric N Miller, Christopher Cox, Sandra Reynolds, James T Becker, Eileen Martin, Ola A Selnes, David G Ostrow, Ned C Sacktor
BACKGROUND: The demographics of the HIV epidemic in the USA have shifted towards older age. We aimed to establish the relationship between the processes of ageing and HIV infection in neurocognitive impairment. METHODS: With longitudinal data from the Multicenter AIDS Cohort Study, a long-term prospective cohort study of the natural and treated history of HIV infection among men who have sex with men in the USA, we examined the effect of ageing, HIV infection (by disease stage), and their interaction on five neurocognitive domains: information processing speed, executive function, episodic memory, working memory, and motor function...
July 14, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28716441/unraveling-the-meaning-of-chemical-shifts-in-protein-nmr
#7
REVIEW
Mark V Berjanskii, David S Wishart
Chemical shifts are among the most informative parameters in protein NMR. They provide wealth of information about protein secondary and tertiary structure, protein flexibility, and protein-ligand binding. In this report, we review the progress in interpreting and utilizing protein chemical shifts that has occurred over the past 25years, with a particular focus on the large body of work arising from our group and other Canadian NMR laboratories. More specifically, this review focuses on describing, assessing, and providing some historical context for various chemical shift-based methods to: (1) determine protein secondary and super-secondary structure; (2) derive protein torsion angles; (3) assess protein flexibility; (4) predict residue accessible surface area; (5) refine 3D protein structures; (6) determine 3D protein structures and (7) characterize intrinsically disordered proteins...
July 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28710145/a-systematic-review-of-the-effects-of-polyols-on-gastrointestinal-health-and-irritable-bowel-syndrome
#8
REVIEW
Adrienne Lenhart, William D Chey
Polyols are sugar alcohols found in certain fruits, vegetables, and sugar-free sweeteners. They make up a component of the diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols, which is gaining popularity in the treatment of patients with irritable bowel syndrome (IBS). We conducted a systematic review to evaluate the effects of polyols on the gastrointestinal tract in healthy men and women and in patients with IBS. Utilizing PubMed, Ovid, and Embase databases, we conducted a search on individual polyols and each of these terms: fermentation, absorption, motility, permeability, and gastrointestinal symptoms...
July 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28707143/clinical-sleep-wake-disorders-ii-focus-on-insomnia-and-circadian-rhythm-sleep-disorders
#9
Kai Spiegelhalder, Christoph Nissen, Dieter Riemann
Insomnia and circadian rhythm sleep disorders affect large proportions of the population and have pronounced effects on quality of life and daytime performance. While the neurobiology of insomnia is not yet fully understood, circadian rhythm sleep disorders are assumed to be caused by a mismatch between the individual circadian phase position and the desired sleep-wake schedule. Benzodiazepines and non-benzodiazepine positive allosteric GABAA receptor modulators improve sleep onset and maintenance in the short-term treatment of insomnia...
July 14, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28695647/experiences-of-participating-in-return-to-work-group-programmes-for-people-with-musculoskeletal-disorders-a-focus-group-study
#10
Bente Hamnes, Aud Rønningen, Åse Skarbø
PURPOSE: The present study aimed to explore the experiences of individuals with musculoskeletal disorders (MSDs) who had participated in return-to-work group programmes (RTW-GPs) and to assess whether the programmes had had an impact on their work disability. METHOD: Three focus group interviews and one individual interview were conducted involving 17 women (mean age = 47) with MSDs who had completed RTW-GPs. All interviews were audio-recorded, transcribed verbatim and analysed using thematic analyses...
July 11, 2017: Musculoskeletal Care
https://www.readbyqxmd.com/read/28684405/sleep-loss-as-a-trigger-of-mood-episodes-in-bipolar-disorder-individual-differences-based-on-diagnostic-subtype-and-gender
#11
Katie Swaden Lewis, Katherine Gordon-Smith, Liz Forty, Arianna Di Florio, Nick Craddock, Lisa Jones, Ian Jones
BackgroundSleep loss may trigger mood episodes in people with bipolar disorder but individual differences could influence vulnerability to this trigger.AimsTo determine whether bipolar subtype (bipolar disorder type I (BP-I) or II (BD-II)) and gender were associated with vulnerability to the sleep loss trigger.MethodDuring a semi-structured interview, 3140 individuals (68% women) with bipolar disorder (66% BD-I) reported whether sleep loss had triggered episodes of high or low mood. DSM-IV diagnosis of bipolar subtype was derived from case notes and interview data...
July 6, 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28684211/age-related-accumulation-of-phosphorylated-mitofusin-2-protein-in-retinal-ganglion-cells-correlates-with-glaucoma-progression
#12
Mary P Nivison, Nolan G Ericson, Virginia M Green, Jason H Bielas, Jean S Campbell, Philip J Horner
Dysregulation of axonal bioenergetics is likely a key mechanism in the initiation and progression of age-related neurodegenerative diseases. Glaucoma is a quintessential neurodegenerative disorder characterized by progressive deterioration of the optic nerve (ON) and eventual death of retinal ganglion cells (RGCs). Age and elevation of intraocular pressure are key risk factors in glaucoma, but the common early hallmarks of decreased axonal transport and increased bioenergetic vulnerability likely underlie disease initiation...
July 3, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28676771/differences-in-executive-functioning-in-children-with-attention-deficit-and-hyperactivity-disorder-adhd
#13
M Rosa Elosúa, Sandra Del Olmo, María José Contreras
In recent years, the interest in Attention Deficit and Hyperactivity Disorder (ADHD) and its relation to deficits in working memory (WM) and more specifically the different executive functions (EFs) has grown, to the point of confirming that these are quite frequent in this disorder. The aim of this study was precisely to explore differences in executive functioning of WM in fourth grade Primary school children with and without ADHD (26 and 29 children, respectively), introducing rigorous control measures in the tests used...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28676297/inferring-synaptic-excitation-inhibition-balance-from-field-potentials
#14
Richard Gao, Erik J Peterson, Bradley Voytek
Neural circuits sit in a dynamic balance between excitation (E) and inhibition (I). Fluctuations in E:I balance have been shown to influence neural computation, working memory, and information flow, while more drastic shifts and aberrant E:I patterns are implicated in numerous neurological and psychiatric disorders. Current methods for measuring E:I dynamics require invasive procedures that are difficult to perform in behaving animals, and nearly impossible in humans. This has limited the ability to examine the full impact that E:I shifts have in cognition and disease...
July 1, 2017: NeuroImage
https://www.readbyqxmd.com/read/28668637/molecular-differences-between-human-liver-fatty-acid-binding-protein-and-its-t94a-variant-in-their-unbound-and-lipid-bound-states
#15
Mariapina D'Onofrio, Carlo Giorgio Barracchia, Andrea Bortot, Francesca Munari, Serena Zanzoni, Michael Assfalg
Liver fatty acid binding protein (L-FABP) is an abundant cytosolic protein playing a central role in intracellular lipid trafficking. The L-FABP T94A variant, originating from one of the most common polymorphisms in the FABP family, is associated with several lipid-related disorders. However, the molecular factors that determine the observed functional differences are currently unknown. In our work, we performed a high resolution comparative molecular analysis of L-FABP T94T and L-FABP T94A in their unbound states and in the presence of representative ligands of the fatty acid and bile acid classes...
June 29, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28666826/affective-symptoms-in-schizophrenia-are-strongly-associated-with-neurocognitive-deficits-indicating-disorders-in-executive-functions-visual-memory-attention-and-social-cognition
#16
Buranee Kanchanatawan, Supaksorn Thika, George Anderson, Piotr Galecki, Michael Maes
The aim of this study was to assess the neurocognitive correlates of affective symptoms in schizophrenia. Towards this end, 40 healthy controls and 80 schizophrenia patients were investigated with six tests of the Cambridge Neuropsychological Test Automated Battery (CANTAB), assessing spatial working memory, paired-association learning, one touch stocking, rapid visual information (RVP), emotional recognition test and intra/extradimensional set shifting. The Hamilton Depression (HDRS) and Anxiety (HAMA) Rating Scales and the Calgary Depression Scale for Schizophrenia (CDSS) as well as the Positive and Negative Syndrome Scale (PANSS) were also used...
June 27, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28664898/anticancer-activity-of-pterostilbene-in-human-ovarian-cancer-cell-lines
#17
Hui-Lin Pei, Dan-Mei Mu, Bin Zhang
BACKGROUND Epithelial ovarian cancer is a major cause of mortality in women and one of the most common gynecologic disorders. Pterostilbene (PTS), a trans-3,5-dimethoxy-4'-hydroxystilbene, was chosen for this work due to its reported effectiveness as a chemotherapeutic agent in cancer studies. In this work, we studied underlying molecular mechanisms of PTS treatment in various ovarian cancer cell lines such as OVCAR8, OV1063, IGROV-1, and SKOV3. MATERIAL AND METHODS We used the cytometric bead array (CBA) method and real-time PCR analysis to analyze the secretion level of tumor necrosis factor alpha (TNF-α) and to measure the TNF-α mRNA expression...
June 30, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28651909/convergence-and-divergence-of-neurocognitive-patterns-in-schizophrenia-and-depression
#18
Sugai Liang, Matthew R G Brown, Wei Deng, Qiang Wang, Xiaohong Ma, Mingli Li, Xun Hu, Michal Juhas, Xinmin Li, Russell Greiner, Andrew J Greenshaw, Tao Li
BACKGROUND: Neurocognitive impairments are frequently observed in schizophrenia and major depressive disorder (MDD). However, it remains unclear whether reported neurocognitive abnormalities could objectively identify an individual as having schizophrenia or MDD. METHODS: The current study included 220 first-episode patients with schizophrenia, 110 patients with MDD and 240 demographically matched healthy controls (HC). All participants performed the short version of the Wechsler Adult Intelligence Scale-Revised in China; the immediate and delayed logical memory of the Wechsler Memory Scale-Revised in China; and seven tests from the computerized Cambridge Neurocognitive Test Automated Battery to evaluate neurocognitive performance...
June 23, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28646712/prediction-of-vocational-participation-and-global-role-functioning-in-help-seeking-young-adults-from-neurocognitive-demographic-and-clinical-variables
#19
Alice J Cairns, David J Kavanagh, Frances Dark, Steven M McPhail
BACKGROUND: The purpose of this study was to investigate neurocognitive, demographic and clinical correlates of vocational participation among a sample of young help-seeking adults. METHODS: Young people (18-25 years) accessing an early intervention youth health service participated. The Global Functioning: Role scale and level of vocational participation, participant characteristics (age, gender, socioeconomic background and family history of serious mental illness), distress, psychotic-like experiences, substance use, and mental health diagnoses were recorded...
October 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28637048/use-of-light-therapy-by-office-based-physicians
#20
Edda Winkler-Pjrek, Marie Spies, Pia Baldinger-Melich, Lisa Perkmann, Siegfried Kasper, Dietmar Winkler
BACKGROUND: Light therapy (LT) is a non-pharmacological biological treatment that has been used in psychiatry since the 1980s. Previous research has investigated the usage of LT in hospitals. The aim of this study was to examine the pattern of use of LT by office-based physicians. METHODS: A questionnaire was sent by mail to 400 randomly selected doctors in Austria. We made sure that the sample was equally representative of general practitioners (GPs) and psychiatrists, public health service doctors and private doctors, physicians in cities and in the country as well as male and female doctors...
2016: Neuropsychobiology
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