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https://www.readbyqxmd.com/read/28536575/inflammatory-long-pentraxin-3-is-associated-with-leukocyte-telomere-length-in-night-shift-workers
#1
Sofia Pavanello, Mariarita Stendardo, Giuseppe Mastrangelo, Melissa Bonci, Barbara Bottazzi, Manuela Campisi, Marco Nardini, Roberto Leone, Alberto Mantovani, Piera Boschetto
Aging is an emerging worldwide threat to public health, even in the workplace, as it links with risk of illness and death. Bewildered inflammatory responses and stressful conditions associate with age-related disorders. Additionally, circadian rhythm disruption, a critical health issue in night-shift workers, correlates with premature aging. We investigated the hypothesis of a link between altered inflammatory response, detected by plasmatic long pentraxin 3 (PTX3), and biological aging, measured by leukocyte telomere length (LTL), attrition, and possibly induced by night-shift work...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28533625/beneficial-effect-of-interventional-exercise-on-autistic-fragile-x-syndrome
#2
REVIEW
Seunghoon Lee, Jinyoung Won, Sookyoung Park, Sang-Rae Lee, Kyu-Tae Chang, Joo-Heon Kim, Yonggeun Hong
[Purpose] The purpose of the present review is to discuss recent published articles in the understanding of efficacy of interventional exercise on autistic Fragile X syndrome (FXS) with special emphasis on its significance in clinical application in patients. [Methods] This review article was identified scientifically and/or clinically relevant articles from PubMed that directly/indirectly met the inclusion criteria. [Results] Mutation of fragile X mental retardation 1 (fmr1) gene on the X chromosome is related with loss of fragile X mental retardation protein (FMRP) that affecting physiological and behavioral abnormalities...
April 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28533170/synchronizing-effects-of-melatonin-on-diurnal-and-circadian-rhythms
#3
REVIEW
Martina Pfeffer, Horst-Werner Korf, Helmut Wicht
In mammals, the rhythmic secretion of melatonin from the pineal gland is driven by the circadian clock in the suprachiasmatic nucleus (SCN) of the hypothalamus. The robust nightly peak of melatonin secretion is an output signal of the circadian clock and is supposed to deliver the circadian message to the whole of the organism. Since the circadian system regulates many behavioral and physiological processes, its disruption by external (shift-work, jet-lag) or internal desynchronization (blindness, aging) causes many different health problems...
May 19, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28526553/hypothalamic-regulation-of-the-sleep-wake-cycle
#4
REVIEW
Daisuke Ono, Akihiro Yamanaka
Sleep is one of the most important physiological functions in mammals. It is regulated by not only homeostatic regulation but also circadian clock. Several neuropeptide-producing neurons located in the hypothalamus are implicated in the regulation of sleep/wakefulness. Among them, orexin/hypocretin-producing neurons (orexin neurons) are a crucial component for maintenance of wakefulness, because lack of orexin function results in narcolepsy, which is a sleep disorder. Recent findings have identified substances that excite or inhibit neural activity of orexin neurons...
May 16, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/28526480/human-seasonal-and-circadian-studies-in-antarctica-halley-75-0-s
#5
Josephine Arendt, Benita Middleton
Living for extended periods in Antarctica exposes base personnel to extremes of daylength (photoperiod) and temperature. At the British Antarctic Survey base of Halley, 75(0)S, the sun does not rise for 110 d in the winter and does not set for 100 d in summer. Photoperiod is the major time cue governing the timing of seasonal events such as reproduction in many species. The neuroendocrine signal providing photoperiodic information to body physiology is the duration of melatonin secretion which reflects the length of the night: longer in the short days of winter and shorter in summer...
May 16, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28522986/retinal-ganglion-cells-and-circadian-rhythms-in-alzheimer-s-disease-parkinson-s-disease-and-beyond
#6
REVIEW
Chiara La Morgia, Fred N Ross-Cisneros, Alfredo A Sadun, Valerio Carelli
There is increasing awareness on the role played by circadian rhythm abnormalities in neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD). The characterization of the circadian dysfunction parallels the mounting evidence that the hallmarks of neurodegeneration also affect the retina and frequently lead to loss of retinal ganglion cells (RGCs) and to different degrees of optic neuropathy. In the RGC population, there is the subgroup of cells intrinsically photosensitive and expressing the photopigment melanopsin [melanopsin-containing retinal ganglion cells (mRGCs)], which are now well known to drive the entrainment of circadian rhythms to the light-dark cycles...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28522826/disruption-of-melatonin-synthesis-is-associated-with-impaired-14-3-3-and-mir-451-levels-in-patients-with-autism-spectrum-disorders
#7
Cécile Pagan, Hany Goubran-Botros, Richard Delorme, Marion Benabou, Nathalie Lemière, Kerren Murray, Frédérique Amsellem, Jacques Callebert, Pauline Chaste, Stéphane Jamain, Fabien Fauchereau, Guillaume Huguet, Erik Maronde, Marion Leboyer, Jean-Marie Launay, Thomas Bourgeron
Autism spectrum disorders (ASD) are characterized by a wide genetic and clinical heterogeneity. However, some biochemical impairments, including decreased melatonin (crucial for circadian regulation) and elevated platelet N-acetylserotonin (the precursor of melatonin) have been reported as very frequent features in individuals with ASD. To address the mechanisms of these dysfunctions, we investigated melatonin synthesis in post-mortem pineal glands - the main source of melatonin (9 patients and 22 controls) - and gut samples - the main source of serotonin (11 patients and 13 controls), and in blood platelets from 239 individuals with ASD, their first-degree relatives and 278 controls...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28522096/sleep-and-circadian-variability-in-people-with-delayed-sleep-wake-phase-disorder-versus-healthy-controls
#8
Helen J Burgess, Margaret Park, James K Wyatt, Muneer Rizvydeen, Louis F Fogg
OBJECTIVE/BACKGROUND: To compare sleep and circadian variability in adults with delayed sleep-wake phase disorder (DSWPD) to healthy controls. PATIENTS/METHODS: Forty participants (22 DSWPD, 18 healthy controls) completed a ten-day protocol, consisting of DLMO assessments on two consecutive nights, a five-day study break, followed by two more DLMO assessments. All participants were instructed to sleep within one hour of their self-reported average sleep schedule for the last four days of the study break...
June 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28522084/circadian-phase-dynamics-of-subjective-sleepiness-and-sensitivity-to-blue-light-in-young-adults-complaining-of-a-delayed-sleep-schedule
#9
Christophe Moderie, Solenne Van der Maren, Marie Dumont
OBJECTIVE: To assess factors that might contribute to a delayed sleep schedule in young adults with sub-clinical features of delayed sleep phase disorder. METHODS: Two groups of 14 young adults (eight women) were compared: one group complaining of a delayed sleep schedule and a control group with an earlier bedtime and no complaint. For one week, each subject maintained a target bedtime reflecting their habitual sleep schedule. Subjects were then admitted to the laboratory for the assessment of circadian phase (dim light melatonin onset), subjective sleepiness, and non-visual light sensitivity...
June 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28513549/brain-rna-seq-profiling-of-the-mucopolysaccharidosis-type-ii-mouse-model
#10
Marika Salvalaio, Francesca D'Avanzo, Laura Rigon, Alessandra Zanetti, Michela D'Angelo, Giorgio Valle, Maurizio Scarpa, Rosella Tomanin
Lysosomal storage disorders (LSDs) are a group of about 50 genetic metabolic disorders, mainly affecting children, sharing the inability to degrade specific endolysosomal substrates. This results in failure of cellular functions in many organs, including brain that in most patients may go through progressive neurodegeneration. In this study, we analyzed the brain of the mouse model for Hunter syndrome, a LSD mostly presenting with neurological involvement. Whole transcriptome analysis of the cerebral cortex and midbrain/diencephalon/hippocampus areas was performed through RNA-seq...
May 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28511018/daytime-increase-in-caloric-intake-without-change-in-total-24-hr-caloric-intake-can-increase-adiposity-but-not-total-bodyweight-in-rats-with-inverted-feeding-pattern
#11
Lanni Sarmento da Rocha, Rhowena Jane Barbosa de Matos, Julliet Araújo de Souza, Ana Carolina Oliveira Costa, Sandra Lopes de Souza, Giselia de Santana Muniz, Elizabeth Nascimento
GOAL: To evaluate the effect of the food availability period on body weight, self-selection of macronutrients, adiposity, lipoprotein and serum glucose profiles without changing energy intake. METHODS: Young male rats were divided into two groups according to the availability of food during the light and dark phases of the cycle forming two groups: control (CG) and group with inverted feeding pattern (IFPG). Before inversion of food availability on the 80th day, circadian food intake was measured every four hours over 24 hours during three days...
May 16, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28506881/altered-circadian-patterns-of-salivary-cortisol-in-individuals-with-schizophrenia-a-critical-literature-review
#12
Nathalie Coulon, Sylvie Brailly-Tabard, Michel Walter, Sylvie Tordjman
This article focuses on stress vulnerability in schizophrenia through an integrated clinical and biological approach. The objective of this article is to better understand the relationships between vulnerability, stress and schizophrenia. First, the concept of vulnerability is defined and several models of vulnerability in schizophrenia are reviewed. Second, a section is developed on the biology of stress, and more specifically on the stress responses of the hypothalamo-pitutary adrenal (HPA) axis. Then, studies of cortisol circadian rhythms are summarized, suggesting hyper-reactivity of the HPA axis in patients with schizophrenia and high risk individuals for schizophrenia...
May 12, 2017: Journal of Physiology, Paris
https://www.readbyqxmd.com/read/28503116/melatonin-pharmacology-functions-and-therapeutic-benefits
#13
REVIEW
Sylvie Tordjman, Sylvie Chokron, Richard Delorme, Annaëlle Charrier, Eric Bellissant, Nemat Jaafari, Claire Fougerou
BACKGROUND: Melatonin synchronizes central but also peripheral oscillators (fetal adrenal gland, pancreas, liver, kidney, heart, lung, fat, gut, etc.), allowing temporal organization of biological functions through circadian rhythms (24-hour cycles) in relation to periodic environmental changes and therefore adaptation of the individual to his/her internal and external environment. Measures of melatonin are considered the best peripheral indices of human circadian timing based on an internal 24-hour clock...
April 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28502923/g-protein-coupled-receptor-signaling-through-gpr176-gz-and-rgs16-tunes-time-in-the-center-of-the-circadian-clock-review
#14
Kaoru Goto, Masao Doi, Tianyu Wang, Sumihiro Kunisue, Iori Murai, Hitoshi Okamura
G-protein-coupled receptors (GPCRs) constitute an immensely important class of drug targets with diverse clinical applications. There are still more than 120 orphan GPCRs whose cognate ligands and physiological functions are not known. A set of circadian pacemaker neurons that governs daily rhythms in behavior and physiology resides in the suprachiasmatic nucleus (SCN) in the brain. Malfunction of the circadian clock has been linked to a multitude of diseases, such as sleeping disorders, obesity, diabetes, cardiovascular diseases, and cancer, which makes the clock an attractive target for drug development...
May 13, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28502584/up-regulation-of-mir-325-3p-suppresses-pineal-aralkylamine-n-acetyltransferase-aanat-after-neonatal-hypoxia-ischemia-brain-injury-in-rats
#15
Yuanyuan Yang, Bin Sun, Jian Huang, Lixiao Xu, Jian Pan, Chen Fang, Mei Li, Gen Li, Yanfang Tao, Xiaofeng Yang, Ying Wu, Po Miao, Ying Wang, Hong Li, Jing Ren, Meiqin Zhan, Yiping Fang, Xing Feng, Xin Ding
Survivors of hypoxic-ischemic brain damage (HIBD), besides impairment of psychomotor development, often develop circadian rhythm disorders, although the underlying mechanisms are largely unknown. Here, we first verified that mRNA and protein expression of pineal aralkylamine N-acetyltransferase (Aanat), a key regulator for melatonin (MT) synthesis, along with MT, were severely impaired after HIBD. In addition, we demonstrated that neonatal HIBD disrupted the circadian rhythmicity of locomotor activities in juvenile rats...
May 11, 2017: Brain Research
https://www.readbyqxmd.com/read/28502554/the-9-to-5-rodent-time-for-change-scientific-and-welfare-implications-of-circadian-and-light-effects-on-laboratory-mice-and-rats
#16
Penny Hawkins, Huw D R Golledge
Rodents, particularly rats and mice, are the most commonly used laboratory animals and are extensively used in neuroscience research, including as translational models for human disorders. It is common practice to carry out scientific procedures on rats and mice during the daytime, which is the inactive period for these nocturnal species. However, there is increasing evidence for circadian and light-induced effects on rodent physiology and behaviour which may affect the validity of results obtained from mice and rats in neuroscience studies...
May 11, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28500983/night-sleep-influences-white-matter-microstructure-in-bipolar-depression
#17
Francesco Benedetti, Elisa M T Melloni, Sara Dallaspezia, Irene Bollettini, Clara Locatelli, Sara Poletti, Cristina Colombo
BACKGROUND: Alteration of circadian rhythms and sleep disruption are prominent trait-like features of bipolar disorder (BD). Diffusion tensor imaging (DTI) measures suggest a widespread alteration of white matter (WM) microstructure in patients with BD. Sleep promotes myelination and oligodendrocyte precursor cells proliferation. We hypothesized a possible association between DTI measures of WM microstructure and sleep quantity measures in BD. METHODS: We studied 69 inpatients affected by a depressive episode in course of type I BD...
May 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28488943/effect-of-blue-blocking-glasses-in-major-depressive-disorder-with-sleep-onset-insomnia-a-randomized-double-blind-placebo-controlled-study
#18
Yuichi Esaki, Tsuyoshi Kitajima, Ippei Takeuchi, Soji Tsuboi, Osamu Furukawa, Masatsugu Moriwaki, Kiyoshi Fujita, Nakao Iwata
Blue wavelengths form the portion of the visible electromagnetic spectrum that most potently regulates circadian rhythm. We hypothesized that wearing blue-blocking (BB) glasses in the evening may influence circadian rhythm disturbances in patients with major depressive disorder (MDD), resulting in improved sleep and mood. We used a randomized placebo-controlled double-blinded design. Patients with MDD with sleep onset insomnia were randomly assigned to wearing either BB glasses or clear glasses (placebo). Patients were instructed to wear the glasses from 20:00 hours until bedtime for 2 weeks...
May 10, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28488756/cyclic-vomiting-syndrome-in-adults-and-children-a-hypothesis
#19
Sylvain Redon, Cécile Mareau, Eric Guedj, Anne Donnet
OBJECTIVE: To see how patients' clinical descriptions compare to the third classification of International Classification of Headache Disorders (ICHD-III beta). BACKGROUND: CVS is an episodic syndrome associated with migraine. It is a rare disorder of childhood and adulthood. New criteria are proposed in the third classification of International Classification of Headache Disorders. METHODS: This study describes children and adults' CVS characteristics at a French tertiary-care center, according to the ICHD-II and ICHD-III beta criteria...
May 10, 2017: Headache
https://www.readbyqxmd.com/read/28468274/clock-genes-and-altered-sleep-wake-rhythms-their-role-in-the-development-of-psychiatric-disorders
#20
Annaëlle Charrier, Bertrand Olliac, Pierre Roubertoux, Sylvie Tordjman
In mammals, the circadian clocks network (central and peripheral oscillators) controls circadian rhythms and orchestrates the expression of a range of downstream genes, allowing the organism to anticipate and adapt to environmental changes. Beyond their role in circadian rhythms, several studies have highlighted that circadian clock genes may have a more widespread physiological effect on cognition, mood, and reward-related behaviors. Furthermore, single nucleotide polymorphisms in core circadian clock genes have been associated with psychiatric disorders (such as autism spectrum disorder, schizophrenia, anxiety disorders, major depressive disorder, bipolar disorder, and attention deficit hyperactivity disorder)...
April 29, 2017: International Journal of Molecular Sciences
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