keyword
MENU ▼
Read by QxMD icon Read
search

Circadian disorder

keyword
https://www.readbyqxmd.com/read/28919851/deficient-sleep-in-mouse-models-of-fragile-x-syndrome
#1
R Michelle Saré, Lee Harkless, Merlin Levine, Anita Torossian, Carrie A Sheeler, Carolyn B Smith
In patients with fragile X syndrome (FXS), sleep problems are commonly observed but are not well characterized. In animal models of FXS (dfmr1 and Fmr1 knockout (KO)/Fxr2 heterozygote) circadian rhythmicity is affected, but sleep per se has not been examined. We used a home-cage monitoring system to assess total sleep time in both light and dark phases in Fmr1 KO mice at different developmental stages. Fmr1 KOs at P21 do not differ from controls, but genotype × phase interactions in both adult (P70 and P180) groups are statistically significant indicating that sleep in Fmr1 KOs is reduced selectively in the light phase compared to controls...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28912161/disruption-of-bmal1-impairs-blood-brain-barrier-integrity-via-pericyte-dysfunction
#2
Ryota Nakazato, Kenji Kawabe, Daisuke Yamada, Shinsuke Ikeno, Michihiro Mieda, Shigeki Shimba, Eiichi Hinoi, Yukio Yoneda, Takeshi Takarada
Circadian rhythm disturbances are well-established in neurological diseases. However, how these disruptions cause homeostatic imbalances remains poorly understood. Brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein 1 (Bmal1) is a major circadian clock transcriptional activator, and Bmal1 deficiency in male Bmal1nestin(-/-) mice induced marked astroglial activation without affecting the number of astrocytes in the brain and spinal cord. Bmal1 deletion caused blood-brain barrier (BBB) hyperpermeability with an age-dependent loss of pericyte coverage of blood vessels in the brain...
September 14, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28911277/analysis-of-different-melatonin-secretion-patterns-in-children-with-sleep-disorders-melatonin-secretion-patterns-in-children
#3
Ana Checa-Ros, Antonio Muñoz-Hoyos, Antonio Molina-Carballo, Antonio Muñoz-Gallego, Susana Narbona-Galdó, Antonio Jerez-Calero, María Del Carmen Augustín-Morales
The objective of this study was to analyze circadian patterns of urinary 6-sulphatoxymelatonin (aMT6s) excretion in children with primary sleep disorders in comparison with healthy controls. A total of 124 control children and 124 patients (aged 4-14 years) diagnosed with diverse primary sleep disorders were recruited. aMT6s concentrations were measured in diurnal and nocturnal urine, as well as in 24-hour urine. aMT6s levels were significantly higher and showed significantly more evident circadian variations in the control group ( P < ...
October 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28910540/sleep-quality-chronotype-and-metabolic-syndrome-components-in-bipolar-disorders-during-the-remission-period-results-from-the-face-bd-cohort
#4
Ophélia Godin, Chantal Henry, Marion Leboyer, Jean-Michel Azorin, Valerie Aubin, Frank Bellivier, Mircea Polosan, Philippe Courtet, Sebastien Gard, Jean-Pierre Kahn, Josephine Loftus, Christine Passerieux, Dominique Costagliola, Bruno Etain
Data on sleep or circadian abnormalities and metabolic disturbances in euthymic bipolar disorders are scarce and based on small sample sizes. The aim of this study was to explore the associations between sleep disturbances, chronotype and metabolic components in a large sample of euthymic patients with bipolar disorders (BD). From 2009 to 2015, 752 individuals with bipolar disorders from the FACE-BD cohort were included and assessed for sleep quality, chronotype and metabolic components. The Structured Clinical Interview for DSM-IV Axis I Disorders (SCID) was used to confirm the diagnosis of BD...
September 14, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28902457/the-role-of-clock-gene-in-psychiatric-disorders-evidence-from-human-and-animal-research
#5
REVIEW
Jaqueline B Schuch, Julia P Genro, Clarissa R Bastos, Gabriele Ghisleni, Luciana Tovo-Rodrigues
The circadian clock system drives daily rhythms in physiology, metabolism, and behavior in mammals. Molecular mechanisms of this system consist of multiple clock genes, with Circadian Locomotor Output Cycles Kaput (CLOCK) as a core member that plays an important role in a wide range of behaviors. Alterations in the CLOCK gene are associated with common psychiatric disorders as well as with circadian disturbances comorbidities. This review addresses animal, molecular, and genetic studies evaluating the role of the CLOCK gene on many psychiatric conditions, namely autism spectrum disorder, schizophrenia, attention-deficit/hyperactivity disorder, major depressive disorder, bipolar disorder, anxiety disorder, and substance use disorder...
September 13, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28894915/chronobiological-theories-of-mood-disorder
#6
Nevin F W Zaki, David Warren Spence, Ahmed S BaHammam, Seithikurippu R Pandi-Perumal, Daniel P Cardinali, Gregory M Brown
Major depressive disorder (MDD) remains the most prevalent mental disorder and a leading cause of disability, affecting approximately 100 million adults worldwide. The disorder is characterized by a constellation of symptoms affecting mood, anxiety, neurochemical balance, sleep patterns, and circadian and/or seasonal rhythm entrainment. However, the mechanisms underlying the association between chronobiological parameters and depression remain unknown. A PubMed search was conducted to review articles from 1979 to the present, using the following search terms: "chronobiology," "mood," "sleep," and "circadian rhythms...
September 11, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28890168/sleep-disturbances-increase-the-risk-of-dementia-a-systematic-review-and-meta-analysis
#7
REVIEW
Le Shi, Si-Jing Chen, Meng-Ying Ma, Yan-Ping Bao, Ying Han, Yu-Mei Wang, Jie Shi, Michael V Vitiello, Lin Lu
Sleep disturbances and dementia are two common and significant health problems in older adults. Investigations suggest that sleep disturbances might increase the risk of dementia. The aim of the present study was to systematically review and meta-analyze the predictive roles of overall sleep disturbances, their subtypes (e.g., insomnia, sleep disordered breathing [SDB]), and other sleep problems (e.g., excessive daytime sleepiness, sleep-related movement disorder, circadian rhythm sleep disorder, and nonspecific sleep problems) in incident all-cause dementia and Alzheimer's disease (AD) and vascular dementia subtypes...
July 6, 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/28885202/reference-range-and-variability-of-laser-doppler-fluxmetry
#8
C Mrowietz, R P Franke, G Pindur, U Wolf, F Jung
The Laser Doppler technique, a noninvasive method to estimate skin blood flow (LDF), is frequently used in research and clinical routine [1]. Here, the measurements were carried out with a new Laser Doppler system, the DOPsystem, which allows to measure frequency spectra in four different frequency windows according to the velocities in venules (low velocity), capillaries (low to medium velocities), and in arteries (with high and very high velocities). However, the diagnostic reliability or the effectiveness of the LDF has not yet been evaluated sufficiently, which is indispensable, where medical diagnostics and therapy controls are concerned...
September 4, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28884000/catabolic-and-anabolic-faces-of-insulin-resistance-and-their-disorders-a-new-insight-into-circadian-control-of-metabolic-disorders-leading-to-diabetes
#9
REVIEW
Polina M Schwartsburd
Maintenance of glucose homeostasis during circadian behavioral cycles is critical. The processes controlling the switch between predominant lipolysis/fatty oxidation during fasting and predominant lipid storage/glucose oxidation following feeding are determined principally by insulin. Chronic elevated threshold of insulin resistance (IR) is a key pathological feature of obesity, Type 2 diabetes, sepsis and cancer cachexia; however, a temporal reduced threshold of IR is widely met in fasting/hibernation, pregnancy, antibacterial immunity, exercise and stress...
August 2017: Future Science OA
https://www.readbyqxmd.com/read/28881558/-developmental-pattern-of-hypothalamic-pituitary-adrenal-axis-during-pubertal-transition-and-implications-for-emotional-disorders
#10
X N Duan, Y Sun
During an individual's life, puberty is not only a crucial phase for physical development, but a key period for neuroendocrine transformation. As a major neuroendocrine axis, the influence of hypothalamic-pituitary-adrenal (HPA) axis's changes during puberty on mental and physical health, as well as emotional symptoms, is causing a growing attention. However, information of its developing pattern and circadian variation is limited. Recent research has demonstrated that certain developing pattern of HPA axis in puberty is closely related to the adolescent emotional disorders, which highlights the recognition of HPA functions developing paths under both resting and stress state and the evaluation of its prediction effect for the adolescent emotional disorders...
September 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28875581/european-guideline-for-the-diagnosis-and-treatment-of-insomnia
#11
REVIEW
Dieter Riemann, Chiara Baglioni, Claudio Bassetti, Bjørn Bjorvatn, Leja Dolenc Groselj, Jason G Ellis, Colin A Espie, Diego Garcia-Borreguero, Michaela Gjerstad, Marta Gonçalves, Elisabeth Hertenstein, Markus Jansson-Fröjmark, Poul J Jennum, Damien Leger, Christoph Nissen, Liborio Parrino, Tiina Paunio, Dirk Pevernagie, Johan Verbraecken, Hans-Günter Weeß, Adam Wichniak, Irina Zavalko, Erna S Arnardottir, Oana-Claudia Deleanu, Barbara Strazisar, Marielle Zoetmulder, Kai Spiegelhalder
This European guideline for the diagnosis and treatment of insomnia was developed by a task force of the European Sleep Research Society, with the aim of providing clinical recommendations for the management of adult patients with insomnia. The guideline is based on a systematic review of relevant meta-analyses published till June 2016. The target audience for this guideline includes all clinicians involved in the management of insomnia, and the target patient population includes adults with chronic insomnia disorder...
September 5, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28874144/circadian-disruption-promotes-tumor-growth-by-anabolic-host-metabolism-experimental-evidence-in-a-rat-model
#12
Natalí N Guerrero-Vargas, Raful Navarro-Espíndola, Mara A Guzmán-Ruíz, María Del Carmen Basualdo, Estefania Espitia-Bautista, Ana López-Bago, Ricardo Lascurain, Cinthya Córdoba-Manilla, Ruud M Buijs, Carolina Escobar
BACKGROUND: Light at night creates a conflicting signal to the biological clock and disrupts circadian physiology. In rodents, light at night increases the risk to develop mood disorders, overweight, disrupted energy metabolism, immune dysfunction and cancer. We hypothesized that constant light (LL) in rats may facilitate tumor growth via disrupted metabolism and increased inflammatory response in the host, inducing a propitious microenvironment for tumor cells. METHODS: Male Wistar rats were exposed to LL or a regular light-dark cycle (LD) for 5 weeks...
September 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28869341/egcg-ameliorates-insulin-resistance-and-mitochondrial-dysfunction-in-hepg2-cells-involvement-of-bmal1
#13
Yashi Mi, Guoyuan Qi, Yuqi Gao, Runnan Li, Yiwen Wang, Xingyu Li, Shuxian Huang, Xuebo Liu
SCOPE: Normal physiological processes require a robust biological timer called the circadian clock. Dysregulation of circadian rhythms contributes to a variety of metabolic syndrome, including obesity and insulin resistance. EGCG has been demonstrated to possess antioxidant, anti-inflammatory, and cardioprotective bioactivities. The objective of this study was to explore whether circadian clock is involved in the protective effect of EGCG against insulin resistance. METHODS AND RESULTS: The results demonstrated that EGCG reverses the relatively shallow daily oscillations of circadian clock genes transcription and protein expression induced by glucosamine in HepG2 cells...
September 4, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28868955/neurogenetics-of-drosophila-circadian-clock-expect-the-unexpected
#14
Patricia Jarabo, Francisco A Martin
Daily biological rhythms (i.e. circadian) are a fundamental part of animal behavior. Numerous reports have shown disruptions of the biological clock in neurodegenerative disorders and cancer. In the latter case, only recently we have gained insight into the molecular mechanisms. After 45 years of intense study of the circadian rhtythms, we find surprising similarities among species on the molecular clock that governs biological rhythms. Indeed, Drosophila is one of the most widely used models in the study of chronobiology...
September 4, 2017: Journal of Neurogenetics
https://www.readbyqxmd.com/read/28860773/can-melatonin-prevent-or-improve-metabolic-side-effects-during-antipsychotic-treatments
#15
Maria-Cristina Porfirio, Juliana Paula Gomes de Almeida, Maddalena Stornelli, Silvia Giovinazzo, Diane Purper-Ouakil, Gabriele Masi
In the last two decades, second-generation antipsychotics (SGAs) were more frequently used than typical antipsychotics for treating both psychotic and nonpsychotic psychiatric disorders in both children and adolescents, because of their lower risk of adverse neurological effects, that is, extrapyramidal symptoms. Recent studies have pointed out their effect on weight gain and increased visceral adiposity as they induce metabolic syndrome. Patients receiving SGAs often need to be treated with other substances to counteract metabolic side effects...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28860482/circadian-clock-model-supports-molecular-link-between-per3-and-human-anxiety
#16
Amanda R Liberman, Soo Bin Kwon, Ha T Vu, Allan Filipowicz, Ahmet Ay, Krista K Ingram
Generalized anxiety and major depression have become increasingly common in the United States, affecting 18.6 percent of the adult population. Mood disorders can be debilitating, and are often correlated with poor general health, life dissatisfaction, and the need for disability benefits due to inability to work. Recent evidence suggests that some mood disorders have a circadian component, and disruptions in circadian rhythms may even trigger the development of these disorders. However, the molecular mechanisms of this interaction are not well understood...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28858007/the-management-of-sleep-disorders-in-dementia-an-update
#17
Kirsi M Kinnunen, Anastasia Vikhanova, Gill Livingston
PURPOSE OF REVIEW: Sleep disorders in dementia cause distress and may lead to families being unable to care for someone with dementia at home. Recent Cochrane reviews found no interventions of proven effectiveness. There was no effect of light therapy and moderate evidence that melatonin was ineffective both given without knowledge of the patient's circadian rhythm. The current article updates this review by considering newer publications on interventions for sleep disorders or abnormalities of the sleep-wake cycle in people with dementia living in the community...
September 6, 2017: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/28857485/non-alcoholic-fatty-liver-disease-promotes-hepatocellular-carcinoma-through-direct-and-indirect-effects-on-hepatocytes
#18
REVIEW
Chi Ma, Qianfei Zhang, Tim F Greten
Hepatocellular carcinoma (HCC) is the sixth most frequent neoplasm and the second leading cause of cancer-related deaths worldwide. Non-alcoholic fatty liver disease (NAFLD), a common disorder in obese people, has been identified as an important risk factor for HCC. Following the increasing prevalence of obesity, it is expected that the contribution of NAFLD to HCC's incidence worldwide will grow. Recently, a number of studies have been published, which help us better understand cellular and molecular mechanisms of how NAFLD promotes hepatocarcinogensis...
August 31, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28845960/sleep-disorders-circadian-rhythm-sleep-wake-disorders
#19
Deepa Burman
Shift work sleep disorder is a common problem in industrialized countries because of the need for occupations and services to continue to function 24 hours/day. Approximately 20% of employed adults in the United States are engaged in shift work. Shift work sleep disorder is diagnosed if there is a report of insomnia or excessive sleepiness for at least 3 months associated with a recurring work schedule that overlaps the usual time for sleep. Shift work is associated with an increased occurrence of metabolic disorders, such as insulin resistance, diabetes, dyslipidemia, and metabolic syndrome, and it has been implicated in weight gain and cognitive impairment...
September 2017: FP Essentials
https://www.readbyqxmd.com/read/28844867/integrated-stress-response-stimulates-fgf21-expression-systemic-enhancer-of-longevity
#20
REVIEW
Antero Salminen, Kai Kaarniranta, Anu Kauppinen
FGF21 is a multifunctional metabolic and stress hormone which is normally expressed in liver but cellular stress, e.g. mitochondrial or endoplasmic reticulum (ER) stress, can induce its expression and subsequent secretion from several mammalian tissues. The stress kinases of the integrated stress response (ISR) pathway stimulate the expression of FGF21 through the activation of ATF4 transcription factor, thus enhancing cellular stress resistance. The metabolic and stress-inducible transactivation mechanisms of FGF21 gene are mostly mediated through separate pathways...
August 24, 2017: Cellular Signalling
keyword
keyword
25546
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"