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Testosterone replacement therapy

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https://www.readbyqxmd.com/read/29034138/testosterone-pellet-associated-dermatitis-report-and-review-of-testopel-related-cutaneous-adverse-effects
#1
Lucas A Heldt Manica, Philip R Cohen
Testosterone replacement therapy is a treatment utilized for male hypogonadism. A subcutaneous testosterone pellet is a long-acting, slow-release delivery system that can be utilized as androgen replacement therapy. A 77-year-old man who was treated with testosterone pellets developed dermatitis consisting of erythematous plaques and patches on both buttocks and thighs within 28 days following the subcutaneous insertion of testosterone pellets. The skin lesions rapidly resolved with high-potency topical corticosteroid application...
August 11, 2017: Curēus
https://www.readbyqxmd.com/read/29022642/induction-of-puberty-with-human-chorionic-gonadotropin-hcg-followed-by-reversal-of-hypogonadotropic-hypogonadism-in-kallmann-syndrome
#2
Malgorzata Maria Pierzchlewska, Maciej Grzegorz Robaczyk, Ida Vogel
INTRODUCTION: Kallmann syndrome (KS) is a rare, congenital disorder combining hypogonadotropic hypogonadism (HH) due to GnRH-deficiency with anosmia. Traditionally thought to require lifelong therapy it turns out to be a reversible condition in some patients. CASE REPORT: We present a case of a 22-year old man with absent puberty due to KS, in whom genetic testing revealed heterozygosity for a mutation in the PROK2 gene. Pubertal development and virilisation was achieved by using human chorionic gonadotropin (hCG) injections followed by testosterone replacement...
October 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29020729/diagnosing-and-managing-androgen-deficiency-in-men
#3
Raveen Kaur Sandher, Jonathan Aning
Androgens play a crucial role in bone, muscle and fat metabolism, erythropoiesis and cognitive health. In men aged 40-79 years the incidence of biochemical deficiency and symptomatic hypogonadism is 2.1-5.7%. Decreased libido or reduced frequency and quality of erections, fatigue, irritability, infertility or a diminished feeling of wellbeing may be presenting complaints. However, a significant proportion of men with androgen deficiency will be identified when they present for unrelated concerns. Important factors to elicit from the history in addition to the presenting complaint include: a medical history of obesity, type 2 diabetes, systemic diseases or metabolic syndrome which all impact on testosterone physiology...
April 2017: Practitioner
https://www.readbyqxmd.com/read/29018642/pulmonary-embolism-secondary-to-testosterone-enhancing-herbal-supplement-use
#4
Steven M Nguyen, Nway Ko Ko, Asad S Sattar, Esra Gucuk Ipek, Sayed Ali
Decreased testosterone levels in men are often a normal sign of aging. Testosterone replacement therapy (TRT) is a well-established option for those with symptomatic hypogonadism related to low testosterone levels. Conversely, designer herbal supplements in the context of testosterone supplementation are poorly studied, yet remain popular among aging men who seek the well-known, often enhancing, effects of testosterone that involve muscle mass and sexual function/drive. In 2014, the Food and Drug Administration (FDA) issued a warning about the significant risk of venous clots secondary to testosterone product use...
August 6, 2017: Curēus
https://www.readbyqxmd.com/read/28990951/testosterone-replacement-therapy-and-cardiovascular-events
#5
Alp Burak Çatakoğlu, Muammer Kendirci
A low testosterone level and hypogonadism are associated with cardiovascular disease. Aging, chronic health problems, and obesity are all associated with a low testosterone level as well as the presence and severity of cardiovascular disease. Testosterone is increasingly prescribed for patients with clinical hypogonadism and a low testosterone level. The information we have is still contradictory regarding testosterone replacement therapy (TRT) and its association with adverse cardiovascular events. Older patients and patients who are susceptible to cardiovascular diseases could be at risk with a testosterone prescription...
October 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28980739/serum-testosterone-levels-in-male-hypogonadism-why-and-when-to-check-a-review
#6
REVIEW
Mark Livingston, Anura Kalansooriya, Andrew J Hartland, Sudarshan Ramachandran, Adrian Heald
AIM: Although "late onset hypogonadism", a condition that includes low testosterone and symptoms, is common in men over the age of 40 years, diagnosis is not clear cut amongst non-specialists. It is the aim of this review to provide an up to date picture of how this state should be diagnosed and managed. METHODS: We aim to describe how primary and secondary hypogonadism should be excluded before the diagnosis of late onset hypogonadism is reached. As laboratory testosterone measurements are essential the current pitfalls such as inappropriate sample collection and the use of population derived reference ranges are expanded...
October 5, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28954982/androgen-replacement-therapy-for-cancer-related-symptoms-in-male-advanced-cancer-patients-study-protocol-for-a-randomised-prospective-trial-artform-study
#7
Kouji Izumi, Kazuyoshi Shigehara, Takahiro Nohara, Kazutaka Narimoto, Yoshifumi Kadono, Shigeki Nanjo, Tadaaki Yamada, Koushiro Ohtsubo, Seiji Yano, Atsushi Mizokami
Recent studies reveal that hypogonadism with low serum androgen levels is associated with advanced cancer and induction of most cancer-related symptoms. We designed an ARTFORM study to evaluate the efficacy of androgen replacement therapy in male advanced cancer patients. The ARTFORM study is an investigator-initiated, randomised controlled trial comparing intramuscle injection of testosterone enanthate with non-administration in male advanced cancer patients with non-curative locally advanced or metastatic lesions...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28948816/the-influence-of-smoking-and-cessation-on-the-human-reproductive-hormonal-balance
#8
H Jandíková, M Dušková, L Stárka
Smoking is the most widespread substance dependence in the world. Nicotine and some other components of the cigarette smoke cause various endocrine imbalances, and have negative effects on pituitary, thyroid, adrenal, testicular and ovarian functions. Here, we examined studies that describe the influence of smoking and smoking cessation on the male and female reproductive systems. We also focused on studies providing an account of differences in cessation success rates between men and women. In men, the most common effects associated with smoking are erectile dysfunction and decreasing spermiogram quality...
September 26, 2017: Physiological Research
https://www.readbyqxmd.com/read/28946965/testosterone-deficiency-in-dialysis-patients-difference-between-dialysis-techniques
#9
Secundino Cigarrán, Francisco Coronel, Enrique Florit, Jesús Calviño, Juan Villa, Lourdes Gonzalez Tabares, José Antonio Herrero, Juan Jesús Carrero
Testosterone deficiency is a prevalent condition in male patients with chronic kidney disease. However, it is not known whether the type of renal replacement therapy has an impact on testosterone deficiency that accompanies loss of renal function. METHODS: The cross-sectional study enrolled 79 prevalent male patients on dialysis; 43 on haemodialysis (HD) and 36 on peritoneal dialysis (PD). The median age was 69 years and 31.6% were diabetics. Endogenous testosterone levels were measured by immunoluminescence assay (normal range 3-10...
September 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28941963/effects-of-androgen-deprivation-therapy-on-pain-perception-quality-of-life-and-depression-in-men-with-prostate-cancer
#10
Thiago Gagliano-Jucá, Thomas G Travison, Paul L Nguyen, Philip W Kantoff, Mary-Ellen Taplin, Adam S Kibel, Robert Manley, Kathleen Hally, Richelle Bearup, Yusnie M Beleva, Grace Huang, Robert R Edwards, Shehzad Basaria
CONTEXT: Previous animal and human research suggests that testosterone has anti-nociceptive properties. Castration in male rodents increases pain perception which is reversed by testosterone replacement. Pain perception also improves in hypogonadal men with testosterone therapy. However, it remains unclear whether androgen deprivation therapy (ADT) in men with prostate cancer (PCa) is associated with an increase in pain perception. METHODS: Thirty-seven men with PCa about to undergo ADT with leuprolide acetate (ADT group) were followed prospectively for 6 months to evaluate changes in clinical and experimental pain...
September 20, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28924485/hypogonadotropic-hypogonadism-in-human-immunodeficiency-virus-infected-men-uncommonly-low-testosterone-levels
#11
Ana Coelho Gomes, José Maria Aragüés, Sílvia Guerra, Joana Fernandes, Mário Rui Mascarenhas
Hypogonadotropic hypogonadism (HH) is common and occurs prematurely in HIV-infected men. However, HH with very low testosterone has not been described. Three men with normal pubertal development and HIV1 diagnosis at the ages of 22, 34 and 35 years. All complained of decreased libido, anejaculation and erectile dysfunction thirteen years, six months and one year after HIV diagnosis, respectively. Two had depressive syndrome and two were treated with antiretroviral therapy. Laboratory tests revealed isolated HH in all...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28923177/androgens-and-cardiovascular-disease-in-women-and-men
#12
REVIEW
Eleni Armeni, Irene Lambrinoudaki
Cardiovascular disease is the leading cause of death in both women and men. Its pathogenesis is multifactorial, with sex hormones playing an important role. Androgens have both direct and indirect effects on the vasculature. This review summarizes evidence on the association of both endogenous and exogenous androgens with subclinical and overt cardiovascular disease in women and men. Concerning women, both high and low levels of endogenous androgens have been associated with cardiovascular disease, while other studies have reported no association...
October 2017: Maturitas
https://www.readbyqxmd.com/read/28920756/sleep-disturbance-as-a-clinical-sign-for-severe-hypogonadism-efficacy-of-testosterone-replacement-therapy-on-sleep-disturbance-among-hypogonadal-men-without-obstructive-sleep-apnea
#13
Kazuyoshi Shigehara, Hiroyuki Konaka, Kazuhiro Sugimoto, Takahiro Nohara, Koji Izumi, Yoshifumi Kadono, Mikio Namiki, Atsushi Mizokami
OBJECTIVE: The present subanalysis of the EARTH study investigates the effects of one year testosterone replacement therapy (TRT) on sleep disturbance among hypogonadal men without obstructive sleep apnea. METHODS: Sleep disturbance was defined as three or more points in question 4 of the aging males symptoms (AMS) questionnaire. All participants completed the AMS scale, International Prostatic Symptoms Score (IPSS), Sexual Health Inventory for Men (SHIM) and Short Form 36 (SF-36) health survey at baseline and after 12 months...
September 18, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28914503/testosterone-therapy-preserves-muscle-strength-and-power-in-aging-men-with-type-2-diabetes-a-randomized-controlled-trial
#14
L V Magnussen, L G Hvid, A P Hermann, D M Hougaard, B Gram, P Caserotti, M S Andersen
The purpose of the study was to evaluate whether testosterone replacement therapy improves muscle mechanical and physical function in addition to increasing lean leg mass and total lean body mass in aging men with type 2 diabetes and lowered bio-available testosterone (BioT) levels. Thirty-nine men aged 50-70 years with type 2 diabetes and BioT levels <7.3 nmol/L were included from an academic tertiary-care medical center. Patients were randomized to testosterone gel (testosterone replacement therapy, n = 20) or placebo (n = 19) for 24 weeks, applying a double-blinded design...
September 2017: Andrology
https://www.readbyqxmd.com/read/28883919/a-case-of-klinefelter-syndrome-with-hypersexual-desire
#15
Kingsley Okolie, Sumathy Perampalam, Anthony Barker, Christopher J Nolan
Klinefelter syndrome (KS) is a chromosomal disorder affecting males, with the typical karyotype of 47,XXY due to a supernumerary X chromosome, which causes progressive testicular failure resulting in androgen deficiency and infertility. Despite it being the most common sex chromosomal disorder, its diagnosis is easily missed. In addition to its classical clinical features of tall stature, gynaecomastia, small testes, and symptoms and signs of hypogonadism including infertility, KS is also often associated with neurocognitive, behavioural and psychiatric disorders...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28881288/hydroxytriazole-derivatives-as-potent-and-selective-aldo-keto-reductase-1c3-akr1c3-inhibitors-discovered-by-bioisosteric-scaffold-hopping-approach
#16
Agnese C Pippione, Alessandro Giraudo, Davide Bonanni, Irene M Carnovale, Elisabetta Marini, Clara Cena, Annalisa Costale, Daniele Zonari, Klaus Pors, Maria Sadiq, Donatella Boschi, Simonetta Oliaro-Bosso, Marco L Lolli
The aldo-keto reductase 1C3 isoform (AKR1C3) plays a vital role in the biosynthesis of androgens, making this enzyme an attractive target for castration-resistant prostate cancer therapy. Although AKR1C3 is a promising drug target, no AKR1C3-targeted agent has to date been approved for clinical use. Flufenamic acid, a non-steroidal anti-inflammatory drug, is known to potently inhibit AKR1C3 in a non-selective manner as COX off-target effects are also observed. To diminish off-target effects, we have applied a scaffold hopping strategy replacing the benzoic acid moiety of flufenamic acid with an acidic hydroxyazolecarbonylic scaffold...
October 20, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28873196/testosterone-replacement-therapy-and-cardiovascular-risk-a-closer-look-to-additional-parameters
#17
T Craig Cheetham, Stephen K VanDenEeden, Steven J Jacobsen
No abstract text is available yet for this article.
September 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28873188/testosterone-replacement-therapy-and-cardiovascular-risk-a-closer-look-at-additional-parameters
#18
Konstantinos Stavropoulos, Konstantinos P Imprialos, Michael Doumas
No abstract text is available yet for this article.
September 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28863017/debate-position-cognition-and-mood-are-not-improved-in-men-administered-exogenous-testosterone-therapy
#19
Swaytha Yalamanchi, Adrian Dobs
PURPOSE OF REVIEW: The purpose of this article is to provide an overview of the increasing evidence suggesting that exogenous testosterone therapy is not associated with improvements in cognition or mood. This article is part of a series, in this issue, in which authors are assigned opinion pieces on controversial topics pertaining to testosterone replacement. RECENT FINDINGS: Testosterone is increasingly being prescribed. Particularly in the setting of recent data suggestive of possible cardiovascular risk associated with its use; a clear understanding of the domains of health that improve with exogenous testosterone use is important...
August 24, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28819863/effects-of-testosterone-treatment-on-hypothalamic-neuroplasticity-in-female-to-male-transgender-individuals
#20
Georg S Kranz, Andreas Hahn, Ulrike Kaufmann, Martin Tik, Sebastian Ganger, René Seiger, Allan Hummer, Christian Windischberger, Siegfried Kasper, Rupert Lanzenberger
Diffusion-weighted imaging (DWI) is used to measure gray matter tissue density and white matter fiber organization/directionality. Recent studies show that DWI also allows for assessing neuroplastic adaptations in the human hypothalamus. To this end, we investigated a potential influence of testosterone replacement therapy on hypothalamic microstructure in female-to-male (FtM) transgender individuals. 25 FtMs were measured at baseline, 4 weeks, and 4 months past treatment start and compared to 25 female and male controls...
August 17, 2017: Brain Structure & Function
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