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https://www.readbyqxmd.com/read/29453817/endocrine-and-psychological-aspects-of-sexual-dysfunction-in-klinefelter-patients
#1
A Ferlin, R Selice, S Angelini, M Di Grazia, N Caretta, F Cavalieri, A Di Mambro, C Foresta
Klinefelter syndrome is a frequent cause of hypogonadism, but despite hundreds of publications on different aspects of Klinefelter syndrome, only a few studies dealt with sexual dysfunction. In particular, testosterone is critical for various aspects of sexual response, but its role on sexuality in Klinefelter syndrome patients is debatable and no studies have evaluated the efficacy of testosterone treatment on sexual dysfunction in these subjects. Furthermore, the impact of psychological and relational aspects on sexual function of Klinefelter syndrome subjects is poorly defined...
February 17, 2018: Andrology
https://www.readbyqxmd.com/read/29446828/novel-insights-on-testicular-volume-and-testosterone-replacement-therapy-in-klinefelter-patients-undergoing-testicular-sperm-extraction-a-retrospective-clinical-study
#2
Andrea Garolla, Riccardo Selice, Massimo Menegazzo, Umberto Valente, Filiberto Zattoni, Massimo Iafrate, Tommaso Prayer-Galetti, Marina Gardiman Paola, Alberto Ferlin, Andrea Di Nisio, Carlo Foresta
STUDY QUESTION: To investigate whether sperm recovery is related to clinical features, hormone parameters and testosterone replacement therapy (TRT) in patients with Klinefelter syndrome (KS). SUMMARY ANSWER: This study provides three interesting insights: i) the probability to retrieve sperm is not related to testicular volume; ii) TRT does not affect sperm retrieval rate (SRR); iii) reduced levels of LH and FSH represent a negative predictor of sperm retrieval in patients with TRT...
February 15, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29438472/klinefelter-syndrome-integrating-genetics-neuropsychology-and-endocrinology
#3
Claus H Gravholt, Simon Chang, Mikkel Wallentin, Jens Fedder, Philip Moore, Anne Skakkebæk
Although first identified over 70 years ago, Klinefelter syndrome (KS) continue to pose significant diagnostic challenges, as many patients are still misdiagnosed, or remain undiagnosed. In fact, as few as 25% of KS patients are accurately diagnosed, and most of these diagnoses are not made until adulthood. Classic characteristics of KS include small testes, infertility, hypergonadothropic hypogonadism, and cognitive impairment. However, the pathophysiology behind KS is not well understood, although genetic effects are also thought to play a role...
February 9, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/29437711/bilateral-testicular-torsion-in-a-36-week-neonate
#4
Michael J H Clarke, Samuel Crocker, David G Bartle, John Apsey
A male neonate born after uncomplicated vaginal delivery at 36 weeks' gestation was noted to have large and firm testicles bilaterally on routine examination. A testicular ultrasound scan was subsequently organised that showed detailed appearances consistent with bilateral testicular torsion. This was thought to have taken place antenatally and as such was unfortunately not suitable for intervention. The patient was therefore managed conservatively with the testicles left to involute naturally. He was started on testosterone replacement therapy after follow-up when gonadotrophin levels were found to be raised and testosterone low (suggesting absent testicular function) and will be closely followed up regarding his future development which is normal to this point...
February 7, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29430665/health-related-physical-fitness-and-quality-of-life-in-men-with-congenital-hypogonadotropic-hypogonadism
#5
K S L Mileski, M Bottaro, L G Grossi-Porto, A Lofrano-Porto
Congenital hypogonadotropic hypogonadism is a rare disorder characterised by impaired testosterone secretion since birth, and represents a valuable model for studying the effects of testosterone replacement therapy (TRT) in humans. This cross-sectional study aimed to investigate all health-related physical fitness (HRPF) components and quality of life in a series of eight men with hypogonadotropic hypogonadism under regular TRT. The study group was compared to a control group of 16 healthy subjects paired for age, body mass index and physical activity...
February 11, 2018: Andrologia
https://www.readbyqxmd.com/read/29419855/-clinical-report-of-testicular-hypoplasia-combined-with-21-hydroxylase-deficiency
#6
Bo Jiang, Dingyuan Ma, Huanhuan Chen, Xiaoyu Yang, Yugui Cui, Zhengfeng Xu, Jiayin Liu
OBJECTIVE To investigate the correlation of 21-hydroxylase deficiency (21-OHD) with male testicular dysplasia. METHODS Clinical data of 8 infertile males with congenital adrenal hyperplasia due to 21-OHD was retrospectively analyzed. In addition, potential mutations of the CYP21A2 gene was detected. RESULTS All patients were referred because of azoospermia or severe oligospermia and had small testis with averaged testicular volume of 6.1 mL. Three patients had testicular adrenal rest tumors. Endocrinologic examinations revealed low levels of leutinizing hormone and follicular stimulating hormone, normal or elevated testosterone, elevated progesterone, elevated or normal adrenocoticotropic hormone, and low or normal cortisol...
February 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/29405166/testosterone-replacement-therapy-dilemmas-and-challenges-in-china-and-asia
#7
Qi An, Yi-Qun Gu
No abstract text is available yet for this article.
February 2, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29396841/metabolic-phenotype-of-male-obesity-related-secondary-hypogonadism-pre-replacement-and-post-replacement-therapy-with-intra-muscular-testosterone-undecanoate-therapy
#8
Georgios K Dimitriadis, Harpal S Randeva, Saboor Aftab, Asad Ali, John G Hattersley, Sarojini Pandey, Dimitris K Grammatopoulos, Georgios Valsamakis, Georgios Mastorakos, T Hugh Jones, Thomas M Barber
AIM: To explore the metabolic phenotype of obesity-related secondary hypogonadism (SH) in men pre-replacement and post-replacement therapy with long-acting intramuscular (IM) testosterone undecanoate (TU). METHODS: A prospective observational pilot study on metabolic effects of TU IM in male obesity-related SH (hypogonadal [HG] group, n = 13), including baseline comparisons with controls (eugonadal [EG] group, n = 15). Half the subjects (n = 7 in each group) had type 2 diabetes mellitus (T2D)...
February 2, 2018: Endocrine
https://www.readbyqxmd.com/read/29393043/new-determinants-for-gallstone-disease
#9
Daniel Mønsted Shabanzadeh
Gallstone disease is highly prevalent in Denmark and other countries of northern Europe, and cholecystectomy for the treatment of clinical gallstone disease is one the most frequently performed surgical procedures. Research efforts for the identification of mechanisms involved in gallstone formation have a long history and the most established include bile cholesterol saturation, gallbladder motor function, and the enterohepatic circulation of secondary bile salts produced by fecal microbiota. A small number of determinants that are believed to affect these mechanisms have been identified until now...
February 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29383868/impact-of-testosterone-replacement-therapy-on-thromboembolism-heart-disease-and-obstructive-sleep-apnea-in-men
#10
Alexander P Cole, Julian Hanske, Wei Jiang, Nicollette K Kwon, Stuart R Lipsitz, Martin N Kathrins, Peter A Learn, Maxine Sun, Adil H Haider, Shehzad S Basaria, Quoc-Dien Trinh
OBJECTIVES: To assess the association of TRT with thromboembolism, cardiovascular disease (stroke, coronary artery disease, and heart failure) and obstructive sleep apnea (OSA). METHODS: A cohort of 3,422 male United States military service members, retirees and their dependents, aged 40-64 was identified, who were prescribed TRT between 2006-2010 for low testosterone. Men in this cohort were matched on a 1:1 basis by age and comorbidities to men without a prescription for TRT...
January 30, 2018: BJU International
https://www.readbyqxmd.com/read/29382506/klinefelter-syndrome-more-than-hypogonadism
#11
REVIEW
George A Kanakis, Eberhard Nieschlag
Klinefelter syndrome (KS) is the most frequent chromosome disorder in males (1:650 newborn males), defined by 47,XXY karyotype. The classical phenotype is that of a tall male with relatively long legs, small, firm testes and gynecomastia. Azoospermia and infertility are almost inevitably present, but may be overcome by TESE and ICSI. Nevertheless, a broad spectrum of phenotypes has been described and >70% of the actually existing KS men may remain undiagnosed throughout their lifespan. Accordingly, hypogonadism is usually not evident until early adulthood and progresses with ageing...
January 27, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29371946/episode-like-pulse-testosterone-supplementation-induces-tumor-senescence-and-growth-arrest-down-modulating-androgen-receptor-through-modulation-of-p-erk1-2-parser81-and-cdk1-signaling-biological-implications-for-men-treated-with-testosterone-replacement-therapy
#12
Giovanni Luca Gravina, Francesco Marampon, Patrizia Sanità, Claudio Festuccia, Chiara Forcella, Luca Scarsella, Anna Jitariuc, Antonella Vetuschi, Roberta Sferra, Alessandro Colapietro, Eleonora Carosa, Susanna Dolci, Andrea Lenzi, Emmanuele A Jannini
Despite the growing body of knowledge showing that testosterone (T) may not significantly affect tumor progression in hypogonadal patients treated for prostate cancer (Pca), the use of this hormone in this population still remains controversial. The effects of continuous or pulsed T stimulation were tested in vitro and in vivo on androgen-sensitive Pca cell lines in order to assess the differential biological properties of these two treatment modalities. Pulsed T treatment resulted in a greater inhibition than continuous T supplementation of tumor growth in vitro and in vivo...
December 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/29367875/myotonic-dystrophy-type-1-with-diabetes-mellitus-mixed-hypogonadism-and-adrenal-insufficiency
#13
Ken Takeshima, Hiroyuki Ariyasu, Tatsuya Ishibashi, Shintaro Kawai, Shinsuke Uraki, Jinsoo Koh, Hidefumi Ito, Takashi Akamizu
Myotonic dystrophy type 1 (DM1) is an autosomal dominant multisystem disease affecting muscles, the eyes and the endocrine organs. Diabetes mellitus and primary hypogonadism are endocrine manifestations typically seen in patients with DM1. Abnormalities of hypothalamic-pituitary-adrenal (HPA) axis have also been reported in some DM1 patients. We present a case of DM1 with a rare combination of multiple endocrinopathies; diabetes mellitus, a combined form of primary and secondary hypogonadism, and dysfunction of the HPA axis...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29355169/sex-and-gender-disparities-in-the-epidemiology-and-outcomes-of-chronic-kidney-disease
#14
REVIEW
Juan Jesus Carrero, Manfred Hecking, Nicholas C Chesnaye, Kitty J Jager
Improved understanding of sex and gender-specific differences in the aetiology, mechanisms and epidemiology of chronic kidney disease (CKD) could help nephrologists better address the needs of their patients. Population-based studies indicate that CKD epidemiology differs by sex, affecting more women than men, especially with regard to stage G3 CKD. The effects of longer life expectancy on the natural decline of glomerular filtration rate (GFR) with age, as well as potential overdiagnosis of CKD through the inappropriate use of GFR equations, might be in part responsible for the greater prevalence of CKD in women...
January 22, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29334271/the-safety-of-available-treatments-of-male-hypogonadism-in-organic-and-functional-hypogonadism
#15
G Corona, G Rastrelli, Y Reisman, A Sforza, M Maggi
In the case of primary male hypogonadism (HG), only testosterone (T) replacement therapy (TRT) is possible whereas when the problem is secondary to a pituitary or hypothalamus alteration both T production and fertility can be, theoretically, restored. We here systematically reviewed and discussed the advantages and limits of medications formally approved for the treatment of HG. Areas covered: Data derived from available meta-analyses of placebo controlled randomized trials (RCTs) were considered and analyzed...
January 15, 2018: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29321947/portal-vein-thrombosis-due-to-an-increase-in-dose-of-testosterone-in-a-young-man-with-klinefelter-syndrome
#16
Waseem Amjad, Salma Khatoon, Twara Tarasaria, Gulru Sharifova
Klinefelter syndrome (KS) is associated with increased incidence of thrombotic events. Hypofibrinolysis is associated with increased risk of thromboembolism. Although testosterone replacement therapy (TRT) inhibits the hypofibrinolysis, it can still cause thrombosis paradoxically due to increased dose and duration of use. Herein, we present a case of a young male diagnosed with KS who was taking testosterone. The dose was increased to boost the energy levels, and the patient presented with abdominal pain. Computed tomography (CT) of the abdomen showed extensive portal vein thrombosis...
November 6, 2017: Curēus
https://www.readbyqxmd.com/read/29310195/re-the-relationship-between-testosterone-replacement-therapy-and-lower-urinary-tract-symptoms-a-systematic-review
#17
Alan J Wein
No abstract text is available yet for this article.
January 2018: Journal of Urology
https://www.readbyqxmd.com/read/29310169/re-testosterone-replacement-therapy-and-risk-of-favorable-and-aggressive-prostate-cancer
#18
David F Penson
No abstract text is available yet for this article.
January 2018: Journal of Urology
https://www.readbyqxmd.com/read/29307293/the-role-of-testosterone-in-ms-risk-and-course
#19
Tanuja Chitnis
There is significant animal model data demonstrating a benefit of testosterone on both inflammatory and neuroprotective mechanisms relevant to multiple sclerosis (MS). Several studies have demonstrated lowered testosterone levels in up to 40% of men with MS. Lower testosterone levels were correlated with worsened scores of physical and cognitive disability. There is increasing data suggesting a role of testosterone in MS risk. A pilot study has demonstrated significant benefits of testosterone replacement therapy on cognitive, radiological, and immunological outcome measures in men with MS...
January 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29275061/deterioration-of-chronotropic-responses-and-heart-rate-recovery-indices-in-men-with-erectile-dysfunction
#20
Faruk Kucukdurmaz, Gurkan Acar, Sefa Resim
INTRODUCTION: Erectile dysfunction (ED) and cardiovascular (CV) diseases share common risk factors and ED has been accepted as an early manifestation of CV disease. Exercise stress testing (EST) is used to evaluate CV functions in men with ED. Low exercise workload, a slower heart rate recovery (HRR) after exercise, and inability to increase heart rate during EST (chronotropic incompetence) are independent negative predictors of adverse CV outcomes. AIM: To assess the association among EST parameters, ED, and testosterone levels...
December 20, 2017: Sexual Medicine
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