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Oncology Updates

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https://www.readbyqxmd.com/read/29331546/clinically-localized-prostate-cancer-aua-astro-suo-guideline-part-ii-recommended-approaches-and-details-of-specific-care-options
#1
Martin G Sanda, Jeffrey A Cadeddu, Erin Kirkby, Ronald C Chen, Tony Crispino, Joann Fontanarosa, Stephen J Freedland, Kirsten Greene, Laurence H Klotz, Danil V Makarov, Joel B Nelson, George Rodrigues, Howard M Sandler, Mary Ellen Taplin, Jonathan R Treadwell
PURPOSE: This guideline is structured to provide a clinical framework stratified by cancer severity to facilitate care decisions and guide the specifics of implementing the selected management options. The summary presented herein represents Part II of the two-part series dedicated to Clinically Localized Prostate Cancer: AUA/ASTRO/SUO Guideline discussing risk stratification and care options by cancer severity. Please refer to Part I for discussion of specific care options and outcome expectations and management...
January 10, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29327681/updated-national-comprehensive-cancer-network-guidelines-for-treatment-of-head-and-neck-cancers-2010-2017
#2
Małgorzata Wierzbicka, Joanna Napierała
INTRODUCTION: The diagnostic and therapeutic recommendations have been changing over the years to improve treatment outcomes and quality of life of Head and Neck Cancer (HNC) patients. AIM: The aim of this study was to present currently recommended Head and Neck Cancer treatment guidelines based on the literature review with particular emphasis on novel approaches the NCCN algorithms. MATERIAL AND METHODS: The review of literature covering articles published in the last five years and pointing out essential changes in HNC treatment regarding evidence based medicine...
December 30, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29325808/dutch-breast-reconstruction-guideline
#3
REVIEW
Marc A M Mureau
Treatment of breast cancer is complex and multidisciplinary by nature, with protocols that are updated continuously. During preoperative multidisciplinary team meetings, regularly there is discussion between team members regarding optimal timing and type of breast reconstruction, due to conflicting interests of oncological and reconstructive treatments. Therefore, a multidisciplinary, evidence-based guideline for breast reconstruction in women undergoing breast conserving therapy or mastectomy for breast cancer, or following prophylactic mastectomy was developed by a multidisciplinary working group...
December 27, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29307469/overview-of-vte-treatment-in-cancer-according-to-clinical-guidelines
#4
Agnes Y Y Lee
Evidence-based clinical practice guidelines are available to provide guidance to clinicians in managing patients living with cancer-associated venous thromboembolism (VTE). While most are developed using rigorous methods and grounded by systematic reviews of the literature, their recommendations do differ because of differences in their grading criteria and interpretation of the data. This can be confusing to practicing clinicians. Also, guidelines are often out of date and cannot keep pace with publications because of the lengthy processes and extensive resources required for completion...
January 3, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29303914/current-opinion-in-urology-2017-focal-therapy-of-small-renal-lesions
#5
Brett A Johnson, Jeffrey A Cadeddu
PURPOSE OF REVIEW: With the increasing incidence of small renal masses (SRMs), ablative technologies are becoming more commonly utilized. With any nascent treatment modality, outcomes literature needs to be constantly re-evaluated. The purpose of this review is to revisit the most updated literature regarding the safety and efficacy of ablative treatments of renal lesions. RECENT FINDINGS: Recent literature demonstrates that small renal tumor ablation is safe and effective...
January 4, 2018: Current Opinion in Urology
https://www.readbyqxmd.com/read/29302642/establishing-musculoskeletal-oncology-service-in-resource-constrained-country-challenges-and-solutions
#6
REVIEW
Obada Hasan, Akbar Zubairi, Zohaib Nawaz, Masood Umer
The burden of orthopedic tumor surgery in Pakistan is not known. Similarly the number of procedures being performed for bone and soft tissue surgery are not known. This is even becoming more challenging where the existence of rules and regulations in health care are next to minimal. Furthermore data recording in our country and case registries hardly exist. Despite the lack of information and resources, with high disease burden on community, various providers provide surgical interventions every day in our settings...
December 2017: International Journal of Surgery. Oncology
https://www.readbyqxmd.com/read/29297903/-pembrolizumab-for-the-treatment-of-melanoma-updates-and-perspectives
#7
Vanna Chiarion Sileni, Mario Mandalà, Paola Queirolo
Checkpoint inhibitors immunotherapy was a breakthrough in anti-tumor treatments. Anti-PD-1 monoclonal antibodies are now a standard of treatment for advanced melanoma patients, with a 3-year overall survival of over 50% and a low rate (<20%) of severe toxicities in the phase 3 studies. The aim of this review was to report the most important updates on anti-PD-1 drug pembrolizumab from ASCO (American Society of Clinical Oncology) and ESMO (European Society for Medical Oncology) 2017 Annual Meetings.
December 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29287618/re-brachytherapy-for-patients-with-prostate-cancer-american-society-of-clinical-oncology-cancer-care-ontario-joint-guideline-update
#8
Alberto Bossi
No abstract text is available yet for this article.
December 26, 2017: European Urology
https://www.readbyqxmd.com/read/29278579/sentinel-lymph-node-surgery-in-prostate-cancer-using-magnetic-particles
#9
Alexander Winter, Svenja Engels, Friedhelm Wawroschek
PURPOSE OF REVIEW: Superparamagnetic iron oxide nanoparticles (SPIONs) are tested to identify sentinel lymph nodes (SLNs) to exploit the advantages of targeted pelvic SLN dissection (sPLND), while circumventing the disadvantages of established radioactive labeling. Here we review recent studies about sPLND in prostate cancer (PCa), including the first results of SLN detection using intraprostatic SPION-injection. RECENT FINDINGS: A recent systematic literature review reveals that the diagnostic accuracy of sPLND is comparable with extended PLND (ePLND)...
December 22, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/29278410/bisphosphonates-for-advanced-prostate-cancer
#10
REVIEW
Sascha Macherey, Ina Monsef, Franziska Jahn, Karin Jordan, Kwok Keung Yuen, Axel Heidenreich, Nicole Skoetz
BACKGROUND: The prevalence and incidence of pain and skeletal complications of metastatic bone disease such as pathologic fractures, spinal cord compression and hypercalcemia is high and an important contributor to morbidity, poor performance status and decreased quality of life. Moreover, pathologic fractures are associated with increased risk of death in people with disseminated malignancies. Therefore, prevention of pain and fractures are important goals in men with prostate cancer at risk for skeletal complications...
December 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29276261/cancer-chemotherapy-update-bevacizumab-etoposide-and-cisplatin-regimen-for-refractory-brain-metastases
#11
Seth A Mayer, Dominic A Solimando, J Aubrey Waddell
The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and the agents, both commercially available and investigational, used to treat malignant diseases. Questions or suggestions for topics should be addressed to Dominic A. Solimando, Jr, President, Oncology Pharmacy Services, Inc, 4201 Wilson Blvd #110-545, Arlington, VA 22203, email: OncRxSvc@comcast...
June 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/29273958/biomarkers-in-breast-cancer-a-consensus-statement-by-the-spanish-society-of-medical-oncology-and-the-spanish-society-of-pathology
#12
R Colomer, I Aranda-López, J Albanell, T García-Caballero, E Ciruelos, M Á López-García, J Cortés, F Rojo, M Martín, J Palacios-Calvo
This consensus statement revises and updates the recommendations for biomarkers use in the diagnosis and treatment of breast cancer, and is a joint initiative of the Spanish Society of Medical Oncology and the Spanish Society of Pathology. This expert group recommends determining in all cases of breast cancer the histologic grade and the alpha-estrogen receptor (ER), progesterone receptor, Ki-67 and HER2 status, in order to assist prognosis and establish therapeutic options, including hormone therapy, chemotherapy and anti-HER2 therapy...
December 22, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29273404/superior-biochemical-recurrence-and-long-term-quality-of-life-outcomes-are-achievable-with-robotic-radical-prostatectomy-after-a-long-learning-curve-updated-analysis-of-a-prospective-single-surgeon-cohort-of-2206-consecutive-cases
#13
James E Thompson, Sam Egger, Maret Böhm, Amila R Siriwardana, Anne-Maree Haynes, Jayne Matthews, Matthijs J Scheltema, Phillip D Stricker
BACKGROUND: Our earlier analysis suggested that robot-assisted radical prostatectomy (RARP) achieved superiority over open radical prostatectomy (ORP) in terms of positive surgical margin (PSM) rates and functional outcomes. OBJECTIVE: With larger sample size and longer follow-up, the objective of this study update is to assess whether our previous findings are upheld and whether the improved PSM rates for RARP after an initial learning curve compared with ORP-as observed in our earlier analysis-ultimately resulted in improved biochemical control...
December 19, 2017: European Urology
https://www.readbyqxmd.com/read/29251399/computerized-pediatric-oncology-prescriptions-review-by-pharmacist-a-descriptive-analysis-and-associated-risk-factors
#14
Claire Hamel, Lionel Tortolano, Elisabeth Bermudez, Romain Desmaris, Sébastien Klein, Florian Slimano, François Lemare
BACKGROUND: Systematic prescription analyses by clinical pharmacists result in pharmacist interventions (PIs) to reduce prescription errors and improve medication safety. PIs are particularly critical in oncology, because antineoplastic drugs are highly toxic with low therapeutic indexes especially in a pediatric population. The aim of this study is to describe PIs in a pediatric oncology department and to identify potential risk factors associated with prescription errors. PROCEDURE: We conducted a 20-month observational study in a pediatric oncology department concerning electronic prescription of injectable chemotherapies was conducted...
December 18, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29251392/impact-of-2013-asco-cap-her2-reporting-guidelines-in-breast-cancer-an-assessment-study-from-indian-oncology-centre-that-primarily-performs-her2-ihc-testing-with-special-emphasis-on-ihc-equivocal-category
#15
Sunil Pasricha, Gurudutt Gupta, Ritu Garg, Anila Sharma, Jatin S Gandhi, Garima Durga, Meenakshi Kamboj, Shrruti Grover, Anurag Mehta
The ASCO/CAP guidelines for HER2 reporting in breast cancer published in 2007 and were updated in 2013 to assure that the right patient receives the targeted therapy. The updated guidelines have lowered the threshold for HER2 positivity criteria and altered the equivocal category for both IHC and FISH. This first study from India addresses the impact of these updated guidelines in the various reporting categories at a tertiary care centre. We compared the trend of HER2 IHC reporting 1 year before (Period A) and 1 year after (Period B) the implementation of updated 2013 ASCO/CAP guidelines...
December 18, 2017: Breast Journal
https://www.readbyqxmd.com/read/29251288/new-year-new-look%C3%A2
#16
Anne Katz
For those of you holding this issue of the Oncology Nursing Forum (ONF) in your hands, the change should be tactile. We have changed the paper stock, and I hope you can feel that change. The pages are thicker and matte, and should feel more substantial against your palms. You might have noticed another change when you looked at the cover-we have updated the design and included titles of articles to entice readers to read what we have published.
January 1, 2018: Oncology Nursing Forum
https://www.readbyqxmd.com/read/29250201/asco-update-lung-cancer
#17
REVIEW
Gudrun Absenger, Jasmin Terzic, Angelika Bezan
In the past few years there have been major changes in the treatment landscape in oncology; lung cancer is affected by those changes like almost no other solid tumor. The rise of further second- and third-line tyrosine kinase inhibitors offers sequential therapy for patients with mutated non-small-cell lung cancer. Immunotherapy has found its way into clinical routine and presents us with new challenges in managing side effects, evaluating treatment response and deciding on how long we treat our patients. The treatment algorithm of lung cancer has changed in the last month and further practice-changing trials are coming up, so treating lung cancer patients shows nowadays a more challenging perspective with the possibility of subsequently applied individual therapies...
2017: Memo
https://www.readbyqxmd.com/read/29242280/results-of-fertility-sparing-surgery-for-expansile-and-infiltrative-mucinous-ovarian-cancers
#18
Sebastien Gouy, Marine Saidani, Amandine Maulard, Slim Bach-Hamba, Enrica Bentivegna, Alexandra Leary, Patricia Pautier, Mojgan Devouassoux-Shisheboran, Catherine Genestie, Philippe Morice
BACKGROUND: No series had been reported focusing on the results of fertility-sparing surgery in stage I mucinous ovarian cancers according to histotype (infiltrative vs. expansile). Investigating such outcomes was the aim of the present study. MATERIALS AND METHODS: The present study was a retrospective analysis of patients treated conservatively with preservation of the uterus and contralateral ovary from 1976 to 2016. The pathology of the tumors was reviewed by two expert pathologists according to the 2014 World Health Organization (WHO) classification criteria...
December 14, 2017: Oncologist
https://www.readbyqxmd.com/read/29238109/present-and-future-roles-of-fdg-pet-ct-imaging-in-the-management-of-gastrointestinal-cancer-an-update
#19
REVIEW
Kazuhiro Kitajima, Masatoyo Nakajo, Hayato Kaida, Ryogo Minamimoto, Kenji Hirata, Masakatsu Tsurusaki, Hiroshi Doi, Yoshiko Ueno, Keitaro Sofue, Yukihisa Tamaki, Koichiro Yamakado
Positron emission tomography/computed tomography (PET/CT) integrated with 2-[18F]fluoro-2-deoxy-D-glucose (FDG) is a useful tool for acquisition of both glucose metabolism and anatomic imaging data, as only a single device and one diagnostic session is required, thus opening a new field in clinical oncologic imaging. FDG-PET/CT has been successfully used for initial staging, restaging, assessment of early treatment response, evaluation of metastatic disease response, and prognostication of intestinal cancer as well as various malignant tumors...
November 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29236202/sentinel-lymph-node-biopsy-and-management-of-regional-lymph-nodes-in-melanoma-american-society-of-clinical-oncology-and-society-of-surgical-oncology-clinical-practice-guideline-update
#20
Sandra L Wong, Mark B Faries, Erin B Kennedy, Sanjiv S Agarwala, Timothy J Akhurst, Charlotte Ariyan, Charles M Balch, Barry S Berman, Alistair Cochran, Keith A Delman, Mark Gorman, John M Kirkwood, Marc D Moncrieff, Jonathan S Zager, Gary H Lyman
PURPOSE: To update the American Society of Clinical Oncology (ASCO)-Society of Surgical Oncology (SSO) guideline for sentinel lymph node (SLN) biopsy in melanoma. METHODS: An ASCO-SSO panel was formed, and a systematic review of the literature was conducted regarding SLN biopsy and completion lymph node dissection (CLND) after a positive sentinel node in patients with melanoma. RESULTS: Nine new observational studies, two systematic reviews and an updated randomized controlled trial (RCT) of SLN biopsy, as well as two randomized controlled trials of CLND after positive SLN biopsy, were included...
December 13, 2017: Annals of Surgical Oncology
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