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Cerebral infarction

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https://www.readbyqxmd.com/read/29678936/effect-of-stroke-thrombolysis-predicted-by-distal-vessel-occlusion-detection
#1
Wolfgang G Kunz, Matthias P Fabritius, Wieland H Sommer, Christopher Höhne, Pierre Scheffler, Lukas T Rotkopf, Wolfgang P Fendler, Bastian O Sabel, Felix G Meinel, Franziska Dorn, Birgit Ertl-Wagner, Maximilian F Reiser, Kolja M Thierfelder
OBJECTIVE: Among ischemic stroke patients with negative CT angiography (CTA), we aimed to determine the predictive value of enhanced distal vessel occlusion detection using CT perfusion postprocessing (waveletCTA) for the treatment effect of IV thrombolysis (IVT). METHODS: Patients were selected from 1,851 consecutive patients who had undergone CT perfusion. Inclusion criteria were (1) significant cerebral blood flow (CBF) deficit, (2) no occlusion on CTA, and (3) infarction confirmed on follow-up...
April 20, 2018: Neurology
https://www.readbyqxmd.com/read/29677548/combination-of-curcumin-and-vagus-nerve-stimulation-attenuates-cerebral-ischemia-reperfusion-injury-induced-behavioral-deficits
#2
Jian Xu, Xinjuan Kong, Hong Xiu, Yihe Dou, Zeyu Wu, Peng Sun
AIM: Previous studies indicated that cerebral ischemia/reperfusion injury (CI/RI) could induce behavioral deficits. Single treatment of vagus nerve stimulation (VNS) or curcumin is reported to restore CI/RI-induced behavioral deficits. However, the synergic effect remains unclear. MATERIALS AND METHODS: Rats were divided into 6 groups: sham, CI/RI, VNS, CI/RI + VNS, VNS + curcumin and CI/RI + VNS + curcumin groups. Each group was further divided into three or four subgroups for further assessments...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29674624/brain-and-spinal-cord-injury-repair-by-implantation-of-human-neural-progenitor-cells-seeded-onto-polymer-scaffolds
#3
Jeong Eun Shin, Kwangsoo Jung, Miri Kim, Kyujin Hwang, Haejin Lee, Il-Sun Kim, Bae Hwan Lee, Il-Shin Lee, Kook In Park
Hypoxic-ischemic (HI) brain injury and spinal cord injury (SCI) lead to extensive tissue loss and axonal degeneration. The combined application of the polymer scaffold and neural progenitor cells (NPCs) has been reported to enhance neural repair, protection and regeneration through multiple modes of action following neural injury. This study investigated the reparative ability and therapeutic potentials of biological bridges composed of human fetal brain-derived NPCs seeded upon poly(glycolic acid)-based scaffold implanted into the infarction cavity of a neonatal HI brain injury or the hemisection cavity in an adult SCI...
April 20, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29673328/effect-of-laser-doppler-flowmetry-and-occlusion-time-on-outcome-variability-and-mortality-in-rat-middle-cerebral-artery-occlusion-inconclusive-results
#4
Edvin Ingberg, Hua Dock, Elvar Theodorsson, Annette Theodorsson, Jakob O Ström
BACKGROUND: Stroke is among the leading causes of death and disability. Although intense research efforts have provided promising treatment options in animals, most clinical trials in humans have failed and the therapeutic options are few. Several factors have been suggested to explain this translational difficulty, particularly concerning methodology and study design. Consistent infarcts and low mortality might be desirable in some, but not all, studies. Here, we aimed to investigate whether the use of laser Doppler flowmetry (LDF) and the occlusion time (60 vs...
April 19, 2018: BMC Neuroscience
https://www.readbyqxmd.com/read/29672312/impact-of-brain-atrophy-on-early-neurological-deterioration-and-outcome-in-severe-ischemic-stroke-treated-by-intravenous-thrombolysis
#5
Olivier Tschirret, Gabriela Moreno Legast, Adeline Mansuy, Nathan Mewton, Marielle Buisson, Salem Hannoun, Leila Chamard, Dominique Sappey-Marinier, Carlos El Khoury, Magali Bischoff, Audrey de Parisot, Laurent Derex, Norbert Nighoghossian, Yves Berthezène, Laura Mechtouff
BACKGROUND: Brain atrophy has shown a protective effect on the risk of early neurological deterioration (END) related to malignant edema in patients with hemispheric infarction but could be deleterious on the outcome. AIMS: We aimed to assess whether brain atrophy has an impact on the risk of END and on the outcome in severe ischemic strokes after intravenous (IV) thrombolysis. METHODS: From a prospective thrombolysis registry, 137 patients who had a National Institutes of Health Stroke Scale (NIHSS) ≥15, MRI at admission, and IV thrombolysis were included...
April 19, 2018: European Neurology
https://www.readbyqxmd.com/read/29671868/secondary-prevention-and-lifestyle-indices-after-stroke-in-a-long-term-perspective
#6
A C Jönsson, H Delavaran, H Lövkvist, M Baturova, S Iwarsson, A Ståhl, B Norrving, A Lindgren
OBJECTIVES: To describe the long-term perspective regarding prevalence of risk factors, secondary stroke prevention, and lifestyle indices after stroke. METHODS: From a population-based one-year cohort (n = 416), we performed an observational study of 145 survivors at 16 months and 10 years after stroke (age 27-97 years) regarding secondary prevention including reaching acceptable treatment goals; nutritional status with focus on underweight; and the lifestyle indices: living situation, level of dependence, and self-assessed health condition...
April 19, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29671862/predictors-of-periprocedural-complications-in-patients-undergoing-percutaneous-coronary-interventions-within-coronary-bypass-grafts
#7
Rafał A Januszek, Artur Dziewierz, Zbigniew Siudak, Tomasz Rakowski, Dariusz Dudek, Stanisław Bartuś
BACKGROUND: During the first decade following the coronary bypass grafting, at least 10 of the patients require percutaneous coronary interventions (PCI) due to graft failure. Saphenous vein grafts (SVG) are innately at a higher risk of periprocedural complications. The present study aimed to investigate predictors of periprocedural complications of PCI within coronary artery bypass grafts. METHODS: This study analyzed data gathered in the Polish National Registry (ORPKI) between January 2015 and December 2016...
April 19, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29670826/characteristics-of-paramedian-pontine-arteries-disease-and-its-association-with-hemoglobina1c
#8
Haiyan Li, Yaqing Shu, Biao Hu, Yongqiang Dai, Yinyao Lin, Yilong Shan, Yuge Wang, Wei Cai, Zhengqi Lu
Objectives: The association of branch atherosclerotic disease (BAD) and diabetes mellitus (DM) in the territory of posterior circulation is rarely discussed. Intracranial BAD was divided into two different types: paramedian pontine arteries (PPA) disease (PPD) and lenticulostriate arteries (LSA) disease. The goal of the study was to evaluate the clinical characteristics of PPD and its association with hemoglobinA1c (HbA1c) in China. Materials and Methods: Radiologically confirmed PPD was defined as an isolated unilateral infarction extending to the ventral surface of the pons...
April 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29669602/cerebral-vasculitis-and-lateral-rectus-palsy-two-rare-central-nervous-system-complications-of-dengue-fever-two-case-reports-and-review-of-the-literature
#9
H M M Herath, J S Hewavithana, C M De Silva, O A R Kularathna, N P Weerasinghe
BACKGROUND: Dengue fever is a common mosquito-borne viral illness with a clinical spectrum ranging from a simple febrile illness to potentially life-threatening complications such as dengue hemorrhagic fever and dengue shock syndrome. Dengue infection can affect many organs, including the central nervous system. The neurological manifestations reported in dengue infections are meningitis, encephalitis, stroke, acute disseminated encephalomyelitis, and Guillain-Barré syndrome. CASE PRESENTATION: We report the cases of two interesting patients with confirmed dengue infection who presented with complications of possible central nervous system vasculitis and cranial nerve palsy...
April 19, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29669322/microrna-381-favors-repair-of-nerve-injury-through-regulation-of-the-sdf-1-cxcr4-signaling-pathway-via-lrrc4-in-acute-cerebral-ischemia-after-cerebral-lymphatic-blockage
#10
Jian-Min Piao, Wei Wu, Zhong-Xi Yang, Yu-Zhen Li, Qi Luo, Jin-Lu Yu
BACKGROUND/AIMS: Acute cerebral ischemia is a manifestation of cerebral vascular insufficiency and has a high mortality. However, the therapy for acute cerebral ischemia is still limited. This study aimed to investigate the effect of microRNA-381 (miR-381) on the repair of nerve injury in rats with acute cerebral ischemia after cerebral lymphatic blockage (CLB) by targeting leucine-rich repeat C4 protein (LRRC4) through the Stromal cell-derived factor-1/CXC chemokine receptor-4 signaling pathway...
April 13, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29668855/the-negative-ultraslow-potential-electrophysiological-correlate-of-infarction-in-the-human-cortex
#11
Janos Lückl, Coline L Lemale, Vasilis Kola, Viktor Horst, Uldus Khojasteh, Ana I Oliveira-Ferreira, Sebastian Major, Maren K L Winkler, Eun-Jeung Kang, Karl Schoknecht, Peter Martus, Jed A Hartings, Johannes Woitzik, Jens P Dreier
Spreading depolarizations are characterized by abrupt, near-complete breakdown of the transmembrane ion gradients, neuronal oedema, mitochondrial depolarization, glutamate excitotoxicity and activity loss (depression). Spreading depolarization induces either transient hyperperfusion in normal tissue; or hypoperfusion (inverse coupling = spreading ischaemia) in tissue at risk for progressive injury. The concept of the spreading depolarization continuum is critical since many spreading depolarizations have intermediate characteristics, as opposed to the two extremes of spreading depolarization in either severely ischaemic or normal tissue...
April 16, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29668582/bilateral-visual-loss-and-cerebral-infarction-after-spleen-embolization-in-a-trauma-patient-with-idiopathic-thrombocytopenic-purpura-a-case-report
#12
Wei-Ting Wang, Yu-Yu Li, Wan-Ching Lin, Jen-Yin Chen, Kuo-Mao Lan, Cheuk-Kwan Sun, Kuo-Chuan Hung
RATIONALE: Splenic artery embolization (SAE) is a common procedure in trauma patients with blunt splenic injuries. We report a case of acute ischemic stroke following orthopedic surgery in a patient with post-SAE reactive thrombocytosis. PATIENT CONCERNS: A 37-year-old woman with idiopathic thrombocytopenic purpura (ITP) suffered from multiple trauma scheduled for open reduction and internal fixation for right tibial and left radius fracture five days after SAE...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29668493/subacute-infarct-volume-with-edema-correction-in-computed-tomography-is-equivalent-to-final-infarct-volume-after-ischemic-stroke-improving-the-comparability-of-infarct-imaging-endpoints-in-clinical-trials
#13
Gabriel Broocks, Tobias Djamsched Faizy, Fabian Flottmann, Gerhard Schön, Sönke Langner, Jens Fiehler, Andre Kemmling, Susanne Gellissen
OBJECTIVES: Final infarct volume is regularly used as an end point of tissue outcome in stroke trials; however, the reported volumes are most commonly derived from early follow-up imaging. Those volumes are significantly impaired by ischemic edema, which causes an overestimation of the true final lesion volume. As net water uptake within ischemic brain can be quantified densitometrically in computed tomography (CT) as recently described, we hypothesized that the final lesion volume can be better estimated by correcting the lesion volume in early follow-up for the corresponding proportion of edema...
April 17, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29668477/clinical-significance-of-the-cerebral-perforating-arteries
#14
Vaso Antunović, Aleksandar Mirčić, Slobodan Marinković, Luciano Brigante, Miloš Mališ, Biljana Georgievski, Miljana Aksić
There is scarce data in the contemporary literature regarding the correlation of the microanatomy of the perforating arteries, their atherosclerosis, and the ischemia in their territory. In order to examine, at least partially, those parameters, the perforating arteries of 12 brains were microdissected or their vascular casts were obtained. In addition, 30 specimens of the perforators were used for a histological and immunohistochemical study. Finally, radiological images of 14 patients with deep cerebral infarcts were examined following a selection among 62 subjects...
December 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/29666731/ischemic-stroke-in-an-hiv-positive-patient-an-initial-presentation-of-neurosyphilis
#15
Kalimullah Jan, Rebecca Hoe Hui Min, Tan Seow Yen, Shekhawat Ravindra Singh
Ischemic stroke occurring in patients with human immunodeficiency virus (HIV) needs to be approached with a vast differential diagnosis in mind. We report a case of middle-aged male patient with immune reconstituted HIV on therapy without known cardiovascular risk factors who had a right middle cerebral artery territory infarct. After a thorough evaluation, he received a final diagnosis of neurosyphilis-associated vasculitis leading to stroke. He recovered without any neurological deficits following treatment with intravenous benzylpenicillin...
2018: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/29665789/idiopathic-basal-ganglia-calcification-associated-with-cerebral-micro-infarcts-a-case-report
#16
Takuma Nishimoto, Fumiaki Oka, Hideyuki Ishihara, Mizuya Shinoyama, Michiyasu Suzuki
BACKGROUND: Idiopathic basal ganglia calcification (IBGC) is a rare neurodegenerative disorder characterized by symmetric intracranial calcium deposition. We report a patient with IBGC associated with cerebral infarction due to impairment of cerebrovascular reactivity based on single-photon emission computed tomography (SPECT) with acetazolamide challenge. CASE PRESENTATION: A 66-year-old male presented with right conjugate deviation, right hemiparesis and total aphasia due to a convulsive seizure...
April 17, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29665308/calcified-cerebral-emboli-incidence-and-implications
#17
Miguel Bardon, Julian Hanson, Bill O'Brien, Adil Naeem
INTRODUCTION: Calcified cerebral emboli are an increasingly recognized cause of ischaemic stroke, although recognition amongst general radiologists and clinicians can be limited. Recent literature suggests that calcified cerebral emboli are likely more common than originally thought. This study aims to define the prevalence of calcified cerebral emboli as the most likely aetiology within a cohort of confirmed cases of acute stroke, as well as compare and contrast these cases with cases of 'incidental' intracranial calcification...
April 17, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29665290/timely-visualization-of-the-collaterals-formed-during-acute-ischemic-stroke-with-fe-3-o-4-nanoparticle-based-mr-imaging-probe
#18
Ting Wang, Yi Hou, Bo Bu, Wenxin Wang, Tiancong Ma, Chunyan Liu, Lan Lin, Lin Ma, Xin Lou, Mingyuan Gao
Ischemic stroke is one of the major leading causes for long-term disability and mortality. Collateral vessels provide an alternative pathway to protect the brain against ischemic injury after arterial occlusion. Aiming at visualizing the collaterals occurring during acute ischemic stroke, an integrin αv β3 -specific Fe3 O4 -Arg-Gly-Asp (RGD) nanoprobe is prepared for magnetic resonance imaging (MRI) of the collaterals. Rat models are constructed by occluding the middle cerebral artery for imaging studies of cerebral ischemia and ischemia-reperfusion on 7...
April 17, 2018: Small
https://www.readbyqxmd.com/read/29665049/protective-effects-of-progranulin-against-focal-cerebral-ischemia-reperfusion-injury-in-rats-by-suppressing-endoplasmic-reticulum-stress-and-nf-%C3%AE%C2%BAb-activation-in-reactive-astrocytes
#19
Qing Shu, Hua Fan, Shi-Jun Li, Dan Zhou, Wei Ma, Xiao-Yan Zhao, Jun-Qiang Yan, Gang Wu
The aim of this study is to explore the effect progranulin (PGRN) has on endoplasmic reticulum (ER) stress and the NF-κB activation in reactive astrocytes found in rat models with focal cerebral ischemia-reperfusion (I/R) injury. Sprague-Dawley (SD) rats were grouped into the sham, I/R, PGRN-high dose, PGRN-low dose, and negative control (NC) groups. TTC staining was applied in order to detect the cerebral infarction volume, a TUNEL assay to detect the apoptosis rate of neurons, an ELISA to measure MDA, SOD, iNOS, LDH, TNF-α, IL-1β, IL-6, and IL-10 levels, and both RT-qPCR and western blotting methods in order to detect PGRN, GFAP, GRP78, CHOP, and NF-κB p65 expressions...
April 17, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29664457/aspergillus-sinusitis-complicated-with-meningitis-and-multiple-cerebral-infarctions-in-immunocompetent-patient
#20
Ahmad AlHaj Houssen, Fahad Algreeshah
This is a case of a 33-year-old male complaining of severe headache, neck pain, photophobia, vomiting and high-grade fever of several days. He had history of nasal polyp removal and recurrent sinusitis in the last 8 years. On examination: conscious with glasco coma scale (GCS) 15/15 and normal limbs strength but with positive Babinski sign. For further observation, he was admitted and full work-up was done. Even though full empirical antibiotics were started, there was no immediate improvement and he deteriorated dramatically developing ocular deficit, hydrocephalus and lower level of consciousness with multiple infarctions found at different areas in brain...
April 2018: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
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