Ilenia Grieco, Maicol Bissaro, Davide Benedetto Tiz, Daniel I Perez, Conception Perez, Ana Martinez, Sara Redenti, Elena Mariotto, Roberta Bortolozzi, Giampietro Viola, Giorgio Cozza, Giampiero Spalluto, Stefano Moro, Stephanie Federico
Protein kinase CK1δ expression and activity is involved in different pathological situations that include neuroinflammatory and neurodegenerative diseases. For this reason, protein kinase CK1δ has become a possible therapeutic target for these conditions. 5,6-fused bicyclic heteroaromatic systems that resemble adenine of ATP represent optimal scaffolds for the development of a new class of ATP competitive CK1δ inhibitors. In particular, a new series of [1,2,4]triazolo[1,5-c]pyrimidines and [1,2,4]triazolo[1,5-a][1,3,5]triazines was developed...
April 15, 2021: European Journal of Medicinal Chemistry