keyword
https://read.qxmd.com/read/38535043/determination-of-l-asparaginase-activity-and-its-therapeutic-monitoring-in-children-with-hematological-malignancies-in-a-single-croatian-center
#1
JOURNAL ARTICLE
Jasna Lenicek Krleza, Ana Katusic Bojanac, Gordana Jakovljevic
BACKGROUND: Among malignant diseases which develop during childhood, hematological cancers, such as leukemias and lymphomas, are the most common. Outcomes have greatly improved due to the refinement of multiagent chemotherapy regimens that include enhanced asparaginase therapy. In this study, we aimed to evaluate our experiences related to the analytical and clinical significance of determining l-Asparaginase activity. METHODS: Since 2016, the Laboratory of the Children's Hospital Zagreb has routinely measured l-Asparaginase activity and to date, has measured more than 280 examples of activity in a total of 57 children with hematological malignancy treated at the Pediatric Oncology Department of the Children's Hospital Zagreb...
March 15, 2024: Diagnostics
https://read.qxmd.com/read/38534076/clinical-evaluation-and-surgical-management-of-ocular-malakoplakia-of-the-caruncle-and-periorbital-region-a-report-of-two-case-and-literature-review
#2
JOURNAL ARTICLE
Chinmayee J Thrishulamurthy, H Shafeeq Ahmed, Mohammed Sohail J, Dayananda S Biligi
Ocular malakoplakia, a rare inflammatory disorder characterized by Michaelis-Gutmann bodies, is presented in 2 unique cases involving uncommon anatomical sites-the orbit and caruncle. The first case describes a 10-year-old girl with localized subconjunctival swelling near the caruncle, prompting surgical excision, and revealing characteristic malakoplakia features. Despite medical management, surgical intervention provided symptom relief. The second case involves a painless swelling below the lower lid in a 23-year-old female, initially suggestive of lymphoma...
March 21, 2024: Ophthalmic Plastic and Reconstructive Surgery
https://read.qxmd.com/read/38531001/international-prognostic-score-for-nodular-lymphocyte-predominant-hodgkin-lymphoma
#3
JOURNAL ARTICLE
Michael Sargent Binkley, Jamie E Flerlage, Kerry J Savage, Saad Akhtar, Raphael Steiner, Xiao-Yin Zhang, Michael Dickinson, Anca Prica, Ajay Major, Peter G Hendrickson, David Hopkins, Andrea Ng, Carla Casulo, Jonathan Baron, Kenneth B Roberts, Jalila Al Kendi, Alex Balogh, Umberto Ricardi, Pallawi Torka, Lena Specht, Ravindu De Silva, Keir Pickard, Lindsay J Blazin, Michael Henry, Christine M Smith, Daniel Halperin, Jessica Brady, Bernadette Brennan, Maria Anatolevna Senchenko, Marie Reeves, Bradford S Hoppe, Stephanie Terezakis, Dipti Talaulikar, Marco Picardi, Youlia Kirova, Paige Fergusson, Eliza A Hawkes, Denise Lee, Nicole Wong Doo, Allison Barraclough, Chan Y Cheah, Matthew Ku, Nada Hamad, Howard Mutsando, Michael Gilbertson, Tamara Marconi, Nicholas Viiala, Matthew J Maurer, Dennis A Eichenauer, Richard T Hoppe
PURPOSE: Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare cancer, and large international cooperative efforts are needed to evaluate the significance of clinical risk factors and immunoarchitectural patterns (IAPs) for all stages of pediatric and adult patients with NLPHL. METHODS: Thirty-eight institutions participated in the Global nLPHL One Working Group retrospective study of NLPHL cases from 1992 to 2021. We measured progression-free survival (PFS), overall survival (OS), transformation rate, and lymphoma-specific death rate...
March 26, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38523951/extramedullary-imaging-manifestations-of-leukemia-lymphoblastic-lymphoma-in-pediatrics-a-case-series
#4
Marcia Mejia, Mónica Royero Arias, Vanessa Santiago Pacheco, Jonathan Pimiento Figueroa
Leukemia is the most common childhood malignancy and often presents with nonspecific symptoms. Occasionally, it presents with extramedullary manifestations, which have been more frequent in cases of myeloid lineage or T cells. However, precursor B-cell leukemia/lymphoblastic lymphoma can also have extramedullary manifestations in some patients. Describing certain clinical features along with diagnostic imaging can establish a presentation pattern and suggest a diagnosis in the pediatric population. Herein, we present a series of four patients with extramedullary manifestations of B-cell lymphoblastic leukemia, describing their clinical imaging and histopathological characteristics...
February 2024: Curēus
https://read.qxmd.com/read/38523827/pediatric-non-hodgkin-lymphoma-as-a-rare-cause-of-spinal-cord-injury-when-lymphoma-hides-in-the-canal
#5
Daniele Zama, Egidio Candela, Gennaro Pagano, Francesco Venturelli, Fraia Melchionda, Francesco Toni, Mino Zucchelli, Andrea Pession
KEY CLINICAL MESSAGE: Spinal cord compression from non-Hodgkin lymphoma (NHL) should be considered as a potential diagnosis in cases of acute signs of myelopathy in pediatric patients. ABSTRACT: Spinal cord compression in pediatric non-Hodgkin lymphoma (NHL) is a rare presentation with potential diagnostic challenges. We report on two pediatric patients with NHL who exhibited myelopathy signs as initial presentation. Considering NHL as a differential diagnosis in pediatric patients presenting with spinal cord compression is crucial for optimizing the outcome of these patients...
March 2024: Clinical Case Reports
https://read.qxmd.com/read/38521927/spontaneous-tumor-lysis-syndrome-stls-during-biopsy-for-burkitt-lymphoma-a-case-report
#6
JOURNAL ARTICLE
Sirui Pan, Qiyang Shen, Jianfeng Zhou, Tao Li
BACKGROUND: Tumor lysis syndrome (TLS) is a hematologic oncological emergency characterized by metabolic and electrolyte imbalances. On breakdown of tumor cells, enormous amounts of potassium, phosphate, and nucleic acids are released into systemic circulation. TLS mainly occurs during chemotherapy. However, there are rare incidences of spontaneous tumor lysis syndrome (STLS) prior to commencement of therapy. CASE PRESENTATION: In the case being reported, the child had just undergone a biopsy...
March 23, 2024: BMC Pediatrics
https://read.qxmd.com/read/38513239/landscape-of-driver-mutations-and-their-clinical-effects-on-down-syndrome-related-myeloid-neoplasms
#7
JOURNAL ARTICLE
Tomohiko Sato, Kenichi Yoshida, Tsutomu Toki, Rika Kanezaki, Kiminori Terui, Ryunosuke Saiki, Masami Ojima, Yotaro Ochi, Seiya Mizuno, Masaharu Yoshihara, Tamayo Uechi, Naoya Kenmochi, Shiro Tanaka, Jun Matsubayashi, Kenta Kisai, Ko Kudo, Kentaro Yuzawa, Yuka Takahashi, Tatsuhiko Tanaka, Yohei Yamamoto, Akie Kobayashi, Takuya Kamio, Shinya Sasaki, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Hideki Muramatsu, Asahito Hama, Daisuke Hasegawa, Atsushi Sato, Katsuyoshi Koh, Shuhei Karakawa, Masao Kobayashi, Junichi Hara, Yuichi Taneyama, Chihaya Imai, Daiichiro Hasegawa, Naoto Fujita, Masahiro Yoshitomi, Shotaro Iwamoto, Genki Yamato, Satoshi Saida, Nobutaka Kiyokawa, Takao Deguchi, Masafumi Ito, Hidemasa Matsuo, Souichi Adachi, Yasuhide Hayashi, Takashi Taga, Akiko Moriya Saito, Keizo Horibe, Kenichiro Watanabe, Daisuke Tomizawa, Satoru Miyano, Satoru Takahashi, Seishi Ogawa, Etsuro Ito
Transient abnormal myelopoiesis (TAM) is a common complication in newborns with Down syndrome (DS). It commonly progresses to myeloid leukemia (ML-DS) after spontaneous regression. In contrast to the favorable prognosis of primary ML-DS, patients with refractory/relapsed ML-DS have poor outcomes. However, the molecular basis for refractoriness and relapse, and the full spectrum of driver mutations in ML-DS remain largely unknown. We conducted a genomic profiling study of 143 TAM, 204 ML-DS, and 34 non-DS acute megakaryoblastic leukemia cases, including 39 ML-DS cases analyzed by exome sequencing...
March 21, 2024: Blood
https://read.qxmd.com/read/38513148/predictive-value-of-early-molecular-response-to-tyrosine-kinase-inhibitors-in-pediatric-patients-with-chronic-myeloid-leukemia
#8
JOURNAL ARTICLE
Aya M Abdallah, Hanafy Hafez, Youssef Madney, Sonia Ahmed, Dina Yassin, Sherine Salem, Rodina Yousry, Hisham Abdel-Azim, Leslie Lehmann, Alaa Elhaddad
No abstract text is available yet for this article.
March 21, 2024: Leukemia & Lymphoma
https://read.qxmd.com/read/38510818/refractory-burkitt-lymphoma-diagnosis-and-interventional-strategies
#9
REVIEW
Francesco Malfona, Anna Maria Testi, Sabina Chiaretti, Maria Luisa Moleti
Despite excellent results in frontline therapy, particularly in pediatric age, refractory Burkitt lymphoma still remains a therapeutic challenge, with dismal outcome. The prognosis is very poor, ranging from less than 10% to 30-40%, with longer survival only in transplanted patients. On account of the paucity of data, mostly reporting on small series of patients, with heterogeneous characteristics and salvage treatments, at present it is impossible to draw definitive conclusions on the treatment of choice for this difficult to treat subset of patients...
2024: Blood and Lymphatic Cancer: Targets and Therapy
https://read.qxmd.com/read/38496369/burkitt-s-lymphoma-in-a-young-boy-progressing-to-systemic-lupus-erythematosus-during-follow-up-a-case-report-and-literature-review
#10
Chenxi Liu, Ci Pan, Yingying Jin, Hua Huang, Fei Ding, Xuemei Xu, Shengfang Bao, Xiqiong Han, Yanliang Jin
INTRODUCTION: Patients with systemic lupus erythematosus (SLE) are at a higher risk of developing cancer, particularly hematological malignancies such as lymphoma and leukemia. However, existing studies on this topic that assess cancer incidence following SLE diagnosis are limited. In addition, SLE can be diagnosed after cancer, although such cases in children have been rarely reported. CASE REPORT: We present the case of a 2.6-year-old boy who presented to our institute with fever and abdominal pain...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38496208/isolated-malignant-pleural-effusion-in-a-child-unusual-presentation-of-acute-leukemia
#11
Srinija Garlapati, Sampada Tambolkar, Sarita Verma, Nakul V Pathak, Manojkumar G Patil
Pleural effusion in the pediatric population is an abnormal pathology characterized by the accumulation of fluids between the parietal and visceral pleura. The etiology of this excessive fluid accumulation can be attributed to both infectious and non-infectious factors. Notably, Streptococcus pneumoniae stands out as the predominant infectious agent responsible for this condition. Non-infectious causative factors encompass hematolymphoid malignancies, congestive heart failure, hemothorax, hypoalbuminemia, and iatrogenic causes...
February 2024: Curēus
https://read.qxmd.com/read/38496108/philadelphia-chromosome-positive-acute-lymphoblastic-leukemia-in-children-a-retrospective-cohort-study-at-a-pediatric-oncology-center
#12
JOURNAL ARTICLE
Leonardo Maia Moço, Ana Fraga, Iris Maia, Marta Almeida
Background and objective Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL Ph+) is quite rare among pediatric patients. Its management has undergone significant changes in the past few years, leading to some variability in how it is approached. At the Portuguese Oncology Institute of Porto (IPOP), a tertiary oncological center, the standard of care has been aligned with the guidelines proposed by the European intergroup study of post-induction treatment of ALL Ph+ (EsPhALL). In this study, we aimed to examine the experience and outcomes related to the treatment of pediatric patients with ALL Ph+ at IPOP...
February 2024: Curēus
https://read.qxmd.com/read/38495131/effect-of-rituximab-on-immune-status-in-children-with-aggressive-mature-b-cell-lymphoma-leukemia-a-prospective-study-from-cccg-bnhl-2015
#13
JOURNAL ARTICLE
Jiajia Dong, Zhou Xu, Xia Guo, Fanghua Ye, Chenying Fan, Ju Gao, Yijin Gao, Liangchun Yang
BACKGROUND: Limited research has been conducted on the impact of rituximab on immune function and the incidence of side effects in children undergoing combination chemotherapy for aggressive mature B-cell lymphoma/leukemia. METHODS: Clinical data from 85 patients with primary pediatric aggressive mature B-cell lymphoma/leukemia, treated according to the Chinese Children's Cancer Group (CCCG)-mature B-cell non-Hodgkin lymphoma (BNHL)-2015 protocol from June 1, 2015, to December 1, 2022, were collected from three tertiary medical centers in China...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38494276/paraneoplastic-cerebellar-and-brainstem-disorders
#14
REVIEW
Justin R Abbatemarco, Christian A Vedeler, John E Greenlee
Paraneoplastic cerebellar and brainstem disorders are a heterogeneous group that requires prompt recognition and treatment to help prevent irreversible neurologic injury. Paraneoplastic cerebellar degeneration is best characterized by Yo antibodies in patients with breast or ovarian cancer. Tr (DNER) antibodies in patients with Hodgkin lymphoma can also present with a pure cerebellar syndrome and is one of the few paraneoplastic syndromes found with hematological malignancy. Opsoclonus-myoclonus-ataxia syndrome presents in both pediatric and adult patients with characteristic clinical findings...
2024: Handbook of Clinical Neurology
https://read.qxmd.com/read/38486828/autologous-hematopoietic-stem-cell-transplant-at-a-tertiary-care-centre-in-india-achieving-comparable-outcomes-with-adaptations
#15
JOURNAL ARTICLE
Aditya Kumar Gupta, Jagdish Prasad Meena, Rachna Seth, Priyanka Naranje, Sujata Mohanty, Poonam Coshic
Autologous stem cell transplantation (ASCT) is the standard treatment for many high-risk solid tumors. Patients undergoing ASCT should be managed in a dedicated hematopoietic stem cell transplantation (HSCT) unit with isolation rooms, high-efficiency particulate air (HEPA) filters, and positive pressure. We report the outcomes of the first 20 pediatric patients who underwent ASCT in isolation rooms with no HEPA filters or positive pressure. Moreover, the isolation rooms were not part of a dedicated HSCT unit...
February 25, 2024: Blood Cell Ther
https://read.qxmd.com/read/38481869/inflammatory-myofibroblastic-tumor-of-the-genitourinary-tract-a-narrative-review
#16
REVIEW
Nikolas Moring, Daniel Swerdloff, Arkar Htoo, Mahmut Akgul, Tipu Nazeer, Badar M Mian
BACKGROUND AND OBJECTIVE: Inflammatory myofibroblastic tumor (IMT) is a rare entity that is described in several organ systems. This comprehensive review aims to identify IMTs occurring at various genitourinary (GU) organ sites and describe patterns of clinical management in adult and pediatric patients. METHODS: A comprehensive search of PubMed and Web of Science was conducted according to the Preferred Reporting Items for Systematic Review and meta-analyses statement...
February 29, 2024: Translational Andrology and Urology
https://read.qxmd.com/read/38473329/anti-pd-1-therapy-in-advanced-pediatric-malignancies-in-nationwide-study-good-outcome-in-skin-melanoma-and-hodgkin-lymphoma
#17
JOURNAL ARTICLE
Agata Marjańska, Katarzyna Pawińska-Wąsikowska, Aleksandra Wieczorek, Monika Drogosiewicz, Bożenna Dembowska-Bagińska, Katarzyna Bobeff, Wojciech Młynarski, Katarzyna Adamczewska-Wawrzynowicz, Jacek Wachowiak, Małgorzata A Krawczyk, Ninela Irga-Jaworska, Jadwiga Węcławek-Tompol, Krzysztof Kałwak, Małgorzata Sawicka-Żukowska, Maryna Krawczuk-Rybak, Anna Raciborska, Agnieszka Mizia-Malarz, Agata Sobocińska-Mirska, Paweł Łaguna, Walentyna Balwierz, Jan Styczyński
BACKGROUND/AIM: The role of immune checkpoint inhibitors (ICIs; anti-PD1) in the treatment of childhood cancers is still evolving. The aim of this nationwide retrospective study was to assess the safety and effectiveness of ICIs used in a group of 42 patients, with a median age of 13.6 years, with various types of advanced malignancies treated in pediatric oncology centers in Poland between 2015 and 2023. RESULTS: The indications for treatment with anti-PD1 were as follows: Hodgkin lymphoma (11); malignant skin melanoma (9); neuroblastoma (8); and other malignancies (14)...
February 28, 2024: Cancers
https://read.qxmd.com/read/38468555/childhood-and-adolescent-relapsed-refractory-aggressive-b-cell-lymphomas-with-t-8-14-and-bcl2-expression-burkitt-lymphoma-versus-diffuse-large-b-cell-lymphoma-a-diagnostic-challenge
#18
JOURNAL ARTICLE
Fouad El Dana, Sofia Alexandra Garces Narvaez, Nader K El-Mallawany, Jennifer E Agrusa, ZoAnn E Dreyer, Andrea N Marcogliese, Mohamed Tarek Elghetany, Jyotinder N Punia, Chi Young Ok, Keyur P Patel, Dolores H Lopez-Terrada, Kevin E Fisher, Choladda V Curry
We present 2 diagnostically challenging cases of pediatric/adolescent relapsed/refractory aggressive mature B-cell non-Hodgkin lymphoma (B-NHL) within the spectrum of Burkitt lymphoma and diffuse large B-cell lymphoma and illustrate the different therapeutic regimens that are employed for pediatric and adult cancer centers. Both cases displayed varying-sized lymphoma cells with occasional single prominent nucleoli and heterogeneous BCL2 expression. Cytogenetics revealed complex karyotypes with t(8:14)(q24.2;q32) and IGH::MYC rearrangement by FISH...
March 11, 2024: Pediatric and Developmental Pathology
https://read.qxmd.com/read/38468389/interfollicular-classic-hodgkin-lymphoma-report-of-a-case-and-a-brief-review-of-literature
#19
JOURNAL ARTICLE
Kristina Brannock, Samir B Kahwash
Interfollicular Hodgkin lymphoma (IHL) has been rarely reported in the literature and is recognized by the WHO Classification as a morphologic pattern sometimes seen in mixed cellularity classic Hodgkin lymphoma (CHL). The changes may be subtle due to preservation of architecture. We report a case of a 9-year-old male with IHL showing preserved follicular architecture but with the presence of interfollicular infiltrates consisting of eosinophils, plasma cells, and Hodgkin-Reed-Sternberg (HRS) cells. Immunophenotyping confirmed the morphologic suspicion for IHL...
March 11, 2024: Pediatric and Developmental Pathology
https://read.qxmd.com/read/38460081/analysis-of-overweight-obese-pediatric-patients-with-acute-myeloid-leukemia-a-report-from-the-japanese-pediatric-leukemia-lymphoma-study-group-aml-05-study
#20
JOURNAL ARTICLE
Hirozumi Sano, Keitaro Fukushima, Michihiro Yano, Shinya Osone, Yoko Kato, Daiichiro Hasegawa, Takako Miyamura, Shotaro Iwamoto, Hiroyuki Takahashi, Kiminori Terui, Akio Tawa, Daisuke Tomizawa
The dosage of chemotherapy drugs for overweight/obese children with acute myeloid leukemia (AML) has been empirically reduced based on ideal body weight (BW) in Japan to reduce the risk of adverse events. We investigated the associations between pre-therapeutic body mass index (BMI) and clinical outcomes among children with AML. A total of 280 children were divided into two groups based on the World Health Organization Child Growth Standards: a healthy-weight group (n = 254), and an overweight/obese group (n = 26)...
March 9, 2024: International Journal of Hematology
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