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Pediatric lymphoma

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https://www.readbyqxmd.com/read/29905933/the-classification-of-pediatric-and-young-adult-renal-cell-carcinomas-registered-on-the-children-s-oncology-group-cog-protocol-aren03b2-after-focused-genetic-testing
#1
Mariana M Cajaiba, Lisa M Dyer, James I Geller, Lawrence J Jennings, David George, Dawn Kirschmann, Stephen M Rohan, Nicholas G Cost, Geetika Khanna, Elizabeth A Mullen, Jeffrey S Dome, Conrad V Fernandez, Elizabeth J Perlman
BACKGROUND: Renal cell carcinomas (RCCs) are rare in young patients. Knowledge of their pathologic and molecular spectrum remains limited, and no prospective studies have been performed to date in this population. This study analyzes patients diagnosed with RCC who were prospectively enrolled in the AREN03B2 Children's Oncology Group (COG). The objective was to classify these tumors with the aid of focused genetic testing and to characterize their features. METHODS: All tumors registered as RCC by central review were retrospectively re-reviewed and underwent additional ancillary studies...
June 15, 2018: Cancer
https://www.readbyqxmd.com/read/29905401/monitoring-pulmonary-health-in-swiss-childhood-cancer-survivors
#2
Rahel Kasteler, Linda M H Kam, Annette Weiss, Nicolas Waespe, Grit Sommer, Florian Singer, Nicolas X von der Weid, Marc Ansari, Claudia E Kuehni
BACKGROUND: Childhood cancer survivors are at increased risk for pulmonary morbidity and mortality. International guidelines recommend pulmonary function tests (PFT) during follow-up care. This nationwide study assessed how many children received PFT within 5 years after pulmotoxic treatment in Switzerland, types of tests, and predictors for testing. METHODS: We included all children from the Swiss Childhood Cancer Registry who were diagnosed with cancer from 1990 to 2013 at age 0-16 years, survived for ≥2 years from diagnosis, and had pulmotoxic chemotherapy with bleomycin, busulfan, nitrosoureas, and/or chest radiotherapy...
June 15, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29901224/pathway-focused-gene-expression-profiles-and-immunohistochemistry-detection-identify-contrasting-association-of-caspase-3-casp3-expression-with-prognosis-in-pediatric-classical-hodgkin-lymphoma
#3
Gabriela Vera-Lozada, Priscilla Segges, Claudio Gustavo Stefanoff, Mário Henrique M Barros, Gerald Niedobitek, Rocio Hassan
The search for clinically relevant molecular markers in classical Hodgkin lymphoma (cHL) is hampered by the histopathological complexity of the disease, resulting from the admixture of a small number of neoplastic Hodgkin and Reed-Sternberg (H-RS) cells with an abundant and heterogeneous microenvironment. In this study, we evaluated gene expression profiles of 11 selected genes previously proposed as a molecular score for adult cHL, aiming to validate its application in the pediatric setting. Assays were performed by RT-qPCR from formalin-fixed paraffin-embedded (FFPE) lymph nodes in 80 patients with cHL...
June 14, 2018: Hematological Oncology
https://www.readbyqxmd.com/read/29899875/characterization-and-diagnostic-application-of-genomic-npm-alk-fusion-sequences-in-anaplastic-large-cell-lymphoma
#4
Manuela Krumbholz, Wilhelm Woessmann, Jakob Zierk, David Seniuk, Paolo Ceppi, Martin Zimmermann, Vijay Kumar Singh, Markus Metzler, Christine Damm-Welk
Nucleophosmin-anaplastic lymphoma kinase ( NPM-ALK) fusion genes resulting from the translocation t(2;5)(p23;q35) are present in almost 90% of childhood ALK-positive anaplastic large-cell lymphomas (ALCL). Detection and quantification of minimal disseminated disease (MDD) by measuring NPM-ALK fusion transcript levels in the blood provide independent prognostic parameters. Characterization of the genomic breakpoints provides insights into the pathogenesis of the translocation and allows for DNA-based minimal disease monitoring...
May 29, 2018: Oncotarget
https://www.readbyqxmd.com/read/29895666/management-of-aggressive-b-cell-nhls-in-the-aya-population-an-adult-versus-pediatric-perspective
#5
Kieron Dunleavy, Thomas G Gross
The adolescents and young adult (AYA) population represent a group where mature B-cell lymphomas constitute a significant proportion of the overall malignancies that occur. Among these are aggressive B-cell non-Hodgkin lymphomas (NHLs) which are predominantly diffuse large B-cell lymphoma (DLBCL), primary mediastinal B-cell lymphoma (PMBCL) and Burkitt lymphoma (BL). For the most part, there is remarkable divide in how pediatric/adolescent patients (under the age of 18 years) with lymphoma are treated versus their young adult counterparts and molecular data are lacking, especially in pediatric and AYA series...
June 12, 2018: Blood
https://www.readbyqxmd.com/read/29895665/the-management-of-hodgkin-lymphoma-in-adolescents-and-young-adults-burden-of-disease-or-burden-of-choice
#6
Jamie E Flerlage, Monika L Metzger, Nickhill Bhakta
Adolescents and young adults (AYAs) comprise the largest age group affected by Hodgkin lymphoma (HL). Despite excellent overall survival of AYA patients with HL due to advances in treatment regimens, therapy-associated late effects continue to be a concern in HL survivors, especially for younger patients who have decades of life remaining. Since the first clinical trial for HL with chemotherapy in 1964, subsequent protocols have attempted to reduce chemotherapy-induced toxicities and yet maintain high overall survival rates...
June 12, 2018: Blood
https://www.readbyqxmd.com/read/29893471/unfavorable-presentation-but-comparable-outcome-presentation-and-outcome-of-children-with-nodular-lymphocyte-predominant-hodgkin-lymphoma-from-india
#7
Maya Prasad, Gaurav Narula, Girish Chinnaswamy, Brijesh Arora, Tanuja Shet, Poonam Panjwani, Manju Sengar, Siddharth Laskar, Nehal Khanna, Shripad Banavali
BACKGROUND: Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is an uncommon subtype of Hodgkin lymphoma (HL) with few published studies in children, entirely from North America and Europe. We analyzed clinical features and treatment outcome of pediatric NLPHL. PROCEDURE: Children less than 18 years of age diagnosed after histopathology review to have NLPHL between June 1998 and August 2016 were retrospectively analyzed. Descriptive details of clinical presentation and treatment were collected, and outcomes analyzed using Kaplan-Meier survival analysis...
June 12, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29893316/malignancy-associated-hemophagocytic-lymphohistiocytosis-in-children
#8
Amitabh Singh, Lesa Dawman, Rachna Seth
Aim of Study: Hemophagocytic lymphohistiocytosis (HLH) is a rare disorder of immune dysregulation resulting in abnormal T-cell activation and inflammatory cytokine production which produces a constellation of clinical features unique to HLH. Pediatric secondary HLH is usually triggered by infection, malignancy, or rheumatological disorders. The diagnosis of malignancy-associated HLH (MA-HLH) poses a difficult challenge as clinical features may be attributed to the underlying disease or chemotherapy...
April 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29884553/analysis-of-the-etiology-and-treatment-of-chylothorax-in-119-pediatric-patients-in-a-single-clinical-center
#9
Chun Wu, Zhengxia Pan, Yuhao Wu, Quan Wang, Yonggang Li, Yong An, Hongbo Li, Gang Wang, Yi Wang, Jiangtao Dai
PURPOSE: To summarize the etiology and treatment of 119 patients with chylothorax in our hospital. METHODS: A total of 119 patients with chylothorax, divided into a neonate group, an infant group, and an older-than-1-year group, were included in our study and analyzed from January 2000 to July 2017 in the Children's Hospital of Chongqing Medical University. RESULTS: A total of 90 males and 29 females were included in our study. In the neonate group, 21 chylothorax cases were due to idiopathic factors, constituting 72...
May 18, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29881715/an-update-from-the-pediatric-proton-consortium-registry
#10
Clayton B Hess, Daniel J Indelicato, Arnold C Paulino, William F Hartsell, Christine E Hill-Kayser, Stephanie M Perkins, Anita Mahajan, Nadia N Laack, Ralph P Ermoian, Andrew L Chang, Suzanne L Wolden, Victor S Mangona, Young Kwok, John C Breneman, John P Perentesis, Sara L Gallotto, Elizabeth A Weyman, Benjamin V M Bajaj, Miranda P Lawell, Beow Y Yeap, Torunn I Yock
Background/objectives: The Pediatric Proton Consortium Registry (PPCR) was established to expedite proton outcomes research in the pediatric population requiring radiotherapy. Here, we introduce the PPCR as a resource to the oncology community and provide an overview of the data available for further study and collaboration. Design/methods: A multi-institutional registry of integrated clinical, dosimetric, radiographic, and patient-reported data for patients undergoing proton radiation therapy was conceived in May 2010...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29876333/pediatric-inflammatory-myofibroblastic-tumors-of-the-airway-two-case-reports-with-varying-clinical-presentation
#11
Nuthan Kumar, Thirunavukkarasu Saravanamuthu, Arathi Srinivasan, Thulasi Raman, Julius-Xavier Scott
Introduction: An inflammatory myofibroblastic tumor (IMT) is a rare tumor of intermediate malignant potential. It may occur in a wide range of anatomical locations. One-third are found in the respiratory tract. We report two cases of IMT of the airway diagnosed at our institution. Case Report: Case 1: A 6-year-old male child presented with a 1-month history of hoarseness of the voice. On evaluation, a polypoid nodule was noted in the right vocal cord which was excised through the endolaryngeal route...
May 2018: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29876052/primary-bilateral-ovarian-burkitt-lymphoma-a-rare-issue-in-gynecologic-oncology
#12
Haneen Al-Maghrabi, Abdelrazak Meliti
We report a rare case of 42-year-old female patient with bilateral primary ovarian Burkitt lymphoma (BL). Primary BLs are rare ovarian oncology neoplasms. Only few cases are reported in English literature, most of them are presented in pediatric and young adult age groups. Rare cases are reported in adult females. Although BL is a rare primary ovarian neoplasm, it is very important to establish an accurate diagnosis as early as possible for therapeutic purposes.
May 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29846760/the-association-of-venous-thromboembolism-with-survival-in-pediatric-cancer-patients-a-population-based-cohort-study
#13
Zara Forbrigger, Stefan Kuhle, Mary Margaret Brown, Paul C Moorehead, Carol Digout, Ketan Kulkarni
Venous thromboembolism (VTE) is a well-recognized complication in pediatric oncology patients. Studies in adult oncology patients have suggested a potential negative association between VTE and survival, but this association has not been examined in pediatric patients yet. The aim of this study was to assess the association of VTE with survival in pediatric oncology patients. Data from all pediatric oncology patients treated at the two tertiary care centers in Atlantic Canada were pooled to create a population-based cohort...
May 30, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29805578/long-non-coding-rna-h19-regulates-viability-and-metastasis-and-is-upregulated-in-retinoblastoma
#14
Li Li, Wei Chen, Yuchuan Wang, Luosheng Tang, Mei Han
Retinoblastoma is the most common type of intraocular pediatric malignant tumor, which typically affects children <6 years of age. However, the underlying molecular mechanisms of retinoblastoma progression remain unclear. The aim of the present study was to investigate the function of long non-coding RNA (lncRNA) H19 in retinoblastoma clinical samples and cell lines, using reverse transcription-quantitative polymerase chain reaction, western blotting, colony formation, MTT, fluorescence activated cell sorting, cell invasion and migration, and in vivo growth assays...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29804713/mechanism-of-cancer-oncohistones-in-action
#15
REVIEW
Lei Qiu, Xiaoyan Hu, Qian Jing, Xinyi Zeng, Kui-Ming Chan, Junhong Han
Oncohistones are histones with high-frequency point mutations that are associated with tumorigenesis. Although each histone variant is encoded by multiple genes, a single mutation in one allele of one gene seems to have a dominant effect over global histone H3 methylation level at the relevant amino acid residue. These oncohistones are highly tumor type specific. For example, H3K27M and H3G34V/R mutations occur only in pediatric brain cancers, whereas H3K36M and H3G34W/L have only been found in pediatric bone tumors...
April 30, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29799894/-extranodal-natural-killer-t-cell-lymphoma-nasal-type-with-primary-cutaneous-involvement-a-case-report
#16
Marcos Silva-Feistner, María Jesús Rojas-Lechuga, Elena Ortiz, Montserrat Molgó
INTRODUCTION: Extranodal natural killer/T-cell lymphoma (NK/T), nasal type, is an infrequent neoplasm with a high lethality, characterized by bone destruction around the sinus, nasal septum or obstruction of the airway. Also, may be primary skin involvement, airway and other organs. Objecti ve: Submit a rare condition in the pediatric population, in order to facilitate the diagnostic suspicion and quick recognition from specialists. CASE REPORT: a 14-year-old girl, who presented arm and leg lesions, painless, suggestive of subcutaneous panniculitis, which evolve to ulcerated purple maculae...
April 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29797952/-the-relationship-between-pathology-and-imaging-overview-in-pediatric-nasal-tumors
#17
J L Liu, L Y Zhang, D F Yao, J E Li
Objective: To study the clinical features and nasal image of children with nasal tumors. Method: The samples of 40 cases of pediatric nasal tumors, which were diagnosed based on pathology, were collected. Clinical features, pathological histology and imaging characteristics were also summarized. Result: There were 23 cases of benign tumors and 17 cases of malignancy. The most common benign tumors were angiofibroma (7 cases), capillary hemangioma (4 cases) and ossifying fibroma (4 cases), while the most common malignant tumors were lymphoma (10 cases) and embryonal rhabdomyosarcoma (3 cases)...
October 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29790693/hounsfield-units-from-unenhanced-18f-fdg-pet-ct-are-useful-in-evaluating-supradiaphragmatic-lymph-nodes-in-children-and-adolescents-with-classical-hodgkin-s-lymphoma
#18
Radosław Chaber, Mateusz Łasecki, Justyna Kwaśnicka, Kornelia Łach, Zbigniew Podgajny, Cyprian Olchowy, Urszula Zaleska-Dorobisz
BACKGROUND: The precise identification of the primarily-affected nodal regions in Hodgkin's lymphoma(HL) is essential in determining the stage of the disease and the intensity of chemotherapy and radiotherapy. OBJECTIVES: The aim of this study was to use the degree of X-ray attenuation (XRA) in Hounsfield units(HU) and the lymph node-to-muscle attenuation ratio (LN/M) in computed tomography (CT) unenhancedimaging, routinely performed with 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET),to distinguish HL-affected supradiaphragmatic lymph nodes...
May 16, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29774105/pre-clinical-activity-of-targeting-the-pi3k-akt-mtor-pathway-in-burkitt-lymphoma
#19
Maria Bhatti, Thomas Ippolito, Cory Mavis, Juan Gu, Mitchell S Cairo, Megan S Lim, Francisco Hernandez-Ilizaliturri, Matthew J Barth
Though outcomes for pediatric Burkitt lymphoma (BL) have improved significantly in recent decades with intensive multi-agent chemotherapy and the addition of rituximab, chemotherapy resistance remains a significant impediment to cure following relapse. Activation of the PI3K/AKT pathway has been implicated in Burkitt lymphomagenesis and increased PI3K/AKT activation has been associated with worse outcomes in adults with aggressive B-cell non-Hodgkin lymphoma (B-NHL). Inhibitors of the PI3K/AKT pathway have been approved for the treatment of refractory indolent B-NHL and continue to be investigated for treatment of aggressive B-NHLs...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29771861/vincristine-associated-neuropathy-with-antifungal-usage-a-kaiser-northern-california-experience
#20
Mina Nikanjam, Aida Sun, Mark Albers, Kristine Mangalindin, Eyun Song, Hyma Vempaty, Danny Sam, Edmund V Capparelli
The dose-limiting toxicity for vincristine is peripheral neuropathy which can be potentiated with concurrent usage of azole antifungals. The current retrospective study assessed the incidence of concurrent vincristine and azole antifungal usage to determine if it led to increased neurotoxicity for the Kaiser Northern California pediatric acute lymphoblastic leukemia (ALL) and Hodgkin lymphoma patient population. Data were obtained from the electronic medical record (2007 to 2014). In total, 130 subjects received at least one dose of vincristine for ALL or Hodgkin lymphoma (median age 9, 88% ALL, 58% male, 47% Caucasian)...
May 16, 2018: Journal of Pediatric Hematology/oncology
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