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https://www.readbyqxmd.com/read/28734183/influence-of-non-measurable-disease-on-progression-free-survival-in-patients-with-metastatic-breast-cancer
#1
REVIEW
Hadar Goldvaser, Domen Ribnikar, Rouhi Fazelzad, Bostjan Seruga, Arnoud J Templeton, Alberto Ocana, Eitan Amir
BACKGROUND: The presence of non-measurable disease is common in metastatic breast cancer. It is unknown whether treatment effect on progression free survival (PFS) is consistent among patients with measurable and non-measurable disease. METHODS: A systematic literature search identified phase III randomized controlled trials (RCTs) in metastatic breast cancer that reported outcomes in patients with non-measurable and measurable disease. Hazard ratios (HRs) and 95% confidence intervals were computed to compare the individual trial treatment effect on PFS in non-measurable versus measurable disease...
July 11, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28734117/hybrid-piezoresistive-optical-tactile-sensor-for-simultaneous-measurement-of-tissue-stiffness-and-detection-of-tissue-discontinuity-in-robot-assisted-minimally-invasive-surgery
#2
Naghmeh M Bandari, Roozbeh Ahmadi, Amir Hooshiar, Javad Dargahi, Muthukumaran Packirisamy
No abstract text is available yet for this article.
July 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28732274/new-source-models-to-represent-the-irradiation-process-in-panoramic-gamma-irradiator
#3
Maritza R Gual, Felix M Milian, Amir Z Mesquita, Claubia Pereira
The use of gamma irradiation technologies generates a number of complex scientific and technical problems; for example, the target is manually loaded onto turntables and is rotated during the entire irradiation process and the MCNPX three-dimensional geometry simulation is kept static. For this, it is necessary to introduce additional approaches. In this paper, two new methodologies are proposed for the simulation of irradiation process in panoramic gamma irradiator. The study was performed at the gamma irradiation facility at the Nuclear Technology Development Center of the National Nuclear Energy Commission, Brazil...
June 30, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28732256/using-the-theory-of-planned-behavior-incorporated-with-perceived-barriers-to-explore-sexual-counseling-services-delivered-by-healthcare-professionals-in-individuals-suffering-from-epilepsy
#4
Chung-Ying Lin, Xavier C C Fung, Mehdi Nikoobakht, Andrea Burri, Amir H Pakpour
People with epilepsy (PWE) are highly likely to suffer from sexual dysfunction, and dealing with this issue is a challenge for healthcare providers. Unfortunately, there is no theory-driven study that has investigated the counseling practice of healthcare providers for sexual problems in PWE. Therefore, we decided to apply the well-established Theory of Planned Behavior (TPB) to examine factors associated with healthcare providers' sexual counseling in PWE. Apart from TPB, perceived barriers toward providing counseling could be a possible factor that needs to be investigated as well...
July 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28732192/cost-and-quality-issues-in-establishing-hematopoietic-cell-transplant-program-in-developing-countries
#5
REVIEW
Shahrukh K Hashmi, Alok Srivastava, Walid Rasheed, Salman Adil, Tong Wu, Madan Jagasia, Amr Nassar, William Y K Hwang, Amir Ali Hamidieh, Hildegard T Greinix, Marcelo C Pasquini, Jane F Apperley, Mahmoud Aljurf
The hematopoietic cell transplant (HCT) activity has grown significantly over the past two decades in both developing and developed countries. Many challenges arise in establishing new HCT programs in developing countries, due to scarcity of resources and manpower in expertise in HCT. While cost issues can potentially hinder establishment of new HCT programs in certain regions, the focus on quality and value should be included in the general vision of leadership before establishing an HCT program. The main challenge in most developing countries is the lack of trained/qualified personnel, enormous start-up costs for a tertiary care center, and quality maintenance...
July 14, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28732161/an-elegant-ph-responsive-nanovehicle-for-drug-delivery-based-on-triazine-dendrimer-modified-magnetic-nanoparticles
#6
Amir Landarani-Isfahani, Majid Moghadam, Shima Mohammadi, Maryam Royvaran, Naimeh Moshtael-Arani, Saghar Rezaei, Shahram Tangestaninejad, Valiollah Mirkhani, Iraj Mohammadpoor-Baltork
Owing to properties of magnetic nanoparticles and elegant three-dimensional macromolecule architectural features, dendrimeric structures have been investigated as nanoscale drug delivery systems. In this paper, a novel magnetic nanocarrier, generation two (G2) triazine dendrimer modified Fe3O4@SiO2 magnetic nanoparticles (MNP-G2), was designed, fabricated and characterized by Fourier transform infrared (FT-IR), thermal gravimetric analysis (TGA), vibrating sample magnetometer (VSM), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM) and dynamic light scattering (DLS)...
July 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28730658/ferroelectrics-as-smart-mechanical-materials
#7
Kumara Cordero-Edwards, Neus Domingo, Amir Abdollahi, Jordi Sort, Gustau Catalan
The mechanical properties of materials are insensitive to space inversion, even when they are crystallographically asymmetric. In practice, this means that turning a piezoelectric crystal upside down or switching the polarization of a ferroelectric should not change its mechanical response. Strain gradients, however, introduce an additional source of asymmetry that has mechanical consequences. Using nanoindentation and contact-resonance force microscopy, this study demonstrates that the mechanical response to indentation of a uniaxial ferroelectric (LiNbO3 ) does change when its polarity is switched, and use this mechanical asymmetry both to quantify its flexoelectricity and to mechanically read the sign of its ferroelectric domains...
July 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28730418/total-and-free-cortisol-levels-during-1-%C3%AE-g-25-%C3%AE-g-and-250-%C3%AE-g-cosyntropin-stimulation-tests-compared-to-insulin-tolerance-test-results-of-a-randomized-prospective-pilot-study
#8
Seenia Peechakara, James Bena, Nigel J Clarke, Michael J McPhaul, Richard E Reitz, Robert J Weil, Pablo Recinos, Laurence Kennedy, Amir H Hamrahian
PURPOSE: The appropriate cosyntropin dose during cosyntropin stimulation tests remains uncertain. We conducted a prospective, randomized pilot study to compare 1 μg IV low dose cosyntropin test, 25 μg IM medium dose cosyntropin test, and 250 μg IM standard dose cosyntropin test to evaluate secondary adrenal insufficiency. Insulin tolerance test was used as the gold standard. METHOD: The study included patients with hypothalamic/pituitary disease (n  = 10) with at least one pituitary axis deficiency other than ACTH deficiency and controls (n  = 12)...
July 20, 2017: Endocrine
https://www.readbyqxmd.com/read/28730280/evidence-for-the-involvement-of-the-gabaergic-but-not-serotonergic-transmission-in-the-anxiolytic-like-effect-of-bisabolol-in-the-mouse-elevated-plus-maze
#9
Mohaddeseh Abouhosseini Tabari, Mohammad Amir Bagherpour Tehrani
Bisabolol (α-(-)-bisabolol) is a sesquiterpene which is a part of the essential oil of a variety of plants, but its common source is German chamomile. Several bioactivities including anti-inflammatory, anti-nociceptive, and anti-tumor effects were attributed to bisabolol. However, the neuropharmacological properties of bisabolol have not yet been reported. The present study evaluated behavioral effects of bisabolol using elevated plus maze (EPM), open field test (OFT), and rotarod test. Moreover, this study also examined whether the 5-HT1A and GABAA-benzodiazepine receptor systems are involved in the anxiolytic-like effects of bisabolol...
July 20, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28730276/effect-of-patient-reported-smoking-status-on-short-term-bariatric-surgery-outcomes
#10
Michael Inadomi, Rahul Iyengar, Ilana Fischer, Xing Chen, Emily Flagler, Amir A Ghaferi
INTRODUCTION: Preoperative patient screening is a major contributor to the remarkable safety of bariatric surgery. Smoking status is a modifiable patient risk factor, and smoking cessation is associated with improved outcomes in surgical patients. However, the length of smoking cessation necessary to optimize bariatric surgery patient outcomes is not yet defined. We sought to explore the relationship between patient-reported smoking status and short-term bariatric surgery outcomes. METHODS: Using prospectively collected data from the MBSC registry, we evaluated the effects of patient-reported length of tobacco abstinence on 30-day surgical outcomes...
July 20, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28730096/retinal-detachment-repair-through-multifocal-intraocular-lens-overcoming-visualization-challenge-of-the-peripheral-retina
#11
Amir Hadayer, Denis Jusufbegovic, Shlomit Schaal
No abstract text is available yet for this article.
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28730087/frequency-of-diabetic-retinopathy-and-associated-risk-factors-in-khartoum-sudan-population-based-study
#12
Einas S Elwali, Ahmed O Almobarak, Mona A Hassan, Amir A Mahmooud, Heitham Awadalla, Mohamed H Ahmed
AIM: To assess the frequency and associated risk factors of diabetic retinopathy among Sudanese individuals with diabetes attending Makka Eye complex in Khartoum, Sudan. METHODS: The cross sectional hospital based study recruited 316 individuals with diabetes from Makkah Eye Complex Retina Clinic. Standard questionnaire was used to collect demographic data, medical history and life style characteristics. Blood samples were taken to measure HbA1c and lipid profile...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28729965/fluid-overload-as-a-major-target-in-management-of-cardiorenal-syndrome-implications-for-the-practice-of-peritoneal-dialysis
#13
REVIEW
Amir Kazory
Congestion is an integral component of cardiorenal syndrome and portends an adverse impact on the outcomes. Recent studies suggest that congestion has the ability of modulating the interactions between the kidney and the heart in this setting. Peritoneal dialysis (PD) is a home-based therapeutic modality that is not only offered to patients with end-stage renal disease to provide solute clearance and ultrafiltration, but it has also been used in patients with refractory heart failure and fluid overload to help optimize volume status...
July 6, 2017: World Journal of Nephrology
https://www.readbyqxmd.com/read/28729327/dietary-intake-and-factors-influencing-eating-behaviours-in-overweight-and-obese-south-asian-men-living-in-the-uk-mixed-method-study
#14
Amir Emadian, Clare Y England, Janice L Thompson
OBJECTIVE: It is widely recognised that South Asian men living in the UK are more likely to develop type 2 diabetes mellitus (T2DM) than their white British counterparts. Despite this, limited data have been published quantifying current dietary intake patterns and qualitatively exploring eating behaviours in this population. The objectives of this study were to (1) assess diet, (2) explore perceptions of T2DM, (3) investigate factors influencing eating behaviours in overweight/obese South Asian men and (4) determine the suitability of the UK Diet and Diabetes Questionnaire (UKDDQ) for use in this population...
July 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28727945/micronutrient-alterations-during-continuous-renal-replacement-therapy-in-critically-ill-adults-a-retrospective-study
#15
Amir Y Kamel, Nisha J Dave, Vivian M Zhao, Daniel P Griffith, Michael J Connor, Thomas R Ziegler
BACKGROUND: Continuous renal replacement therapy (CRRT) is commonly used to provide renal replacement therapy in the intensive care unit. Limited published data suggest that CRRT may lead to depletion of water-soluble vitamins and trace elements. The goal of this study was to identify the incidence of trace element and vitamin deficiencies in critically ill patients during CRRT. MATERIALS AND METHODS: This study is based on a retrospective chart review of patients who were referred to Emory University Hospital's nutrition support services and had at least 1 serum micronutrient level measured during CRRT (thiamin, pyridoxine, ascorbic acid, folate, zinc, and copper) between April 1, 2009, and June 1, 2012...
July 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28727385/abobotulinum-a-toxin-injection-in-patients-with-refractory-idiopathic-detrusor-overactivity-injections-in-detrusor-trigone-and-bladder-neck-or-prostatic-urethra-versus-detrusor-only-injections
#16
Maryam Emami, Pejman Shadpour, Amir H Kashi, Masoud Choopani, Mohammadreza Zeighami
PURPOSE: To evaluate if the injections of abobotulinum-A toxin in trigone and bladder neck/prostatic urethra in addition to detrusor provides better symptoms relief and urodynamic findings in patients with idiopathic detrusor overactivity (IDO) refractory to medical treatment. MATERIALS AND METHODS: A total of 74 patients with IDO refractory to anticholinergics received injections in detrusor, trigone and bladder neck/prostatic urethra (Group A, N=36) versus detrusor only injections (Group B, N=38) of abobotulinum-A toxin...
July 20, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28725486/consequences-of-traumatic-spinal-cord-injury-during-pregnancy-in-pakistan
#17
Aatik Arsh, Haider Darain, Syed Muhammad Ilyas, Amir Zeb
INTRODUCTION: Traumatic spinal cord injury (SCI) is one of the major causes for poor outcomes of pregnancy. Injury during pregnancy is uncommon; therefore, outcome data are scarce. This case series presents outcomes of pregnancy in five women who sustained SCI during their pregnancies. CASE PRESENTATION: Five women who sustained SCIs during pregnancy (age range: 24-38 years) were identified and included in this case series. The causes of SCI in this population were fall from heights (cases 1 and 2), road traffic accidents (cases 3 and 4) and firearm injury (case 5)...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28724896/unprecedented-drought-over-tropical-south-america-in-2016-significantly-under-predicted-by-tropical-sst
#18
Amir Erfanian, Guiling Wang, Lori Fomenko
Tropical and sub-tropical South America are highly susceptible to extreme droughts. Recent events include two droughts (2005 and 2010) exceeding the 100-year return value in the Amazon and recurrent extreme droughts in the Nordeste region, with profound eco-hydrological and socioeconomic impacts. In 2015-2016, both regions were hit by another drought. Here, we show that the severity of the 2015-2016 drought ("2016 drought" hereafter) is unprecedented based on multiple precipitation products (since 1900), satellite-derived data on terrestrial water storage (since 2002) and two vegetation indices (since 2004)...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28724784/representing-delayed-force-feedback-as-a-combination-of-current-and-delayed-states
#19
Guy Avraham, Firas Mawase, Amir Karniel, Lior Shmuelof, Opher Donchin, Ferdinando A Mussa-Ivaldi, Ilana Nisky
To adapt to deterministic force perturbations that depend on the current state of the hand, internal representations are formed to capture the relationships between forces experienced and motion. However, information from multiple modalities travels at different rates, resulting in intermodal delays that require compensation for these internal representations to develop. To understand how these delays are represented by the brain, we presented participants with delayed velocity-dependent force fields; i.e., forces that depend on hand velocity either 70 or 100 ms beforehand...
July 19, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28724272/patients-characteristics-histopathological-findings-and-tumor-stage-in-different-types-of-malignant-melanoma-a-retrospective-multicenter-study
#20
Ali-Mohammad Farahmand, Amir-Hoshang Ehsani, Mojtaba Mirzaei, Maryam Mohsenian, Alireza Ghanadan
Cutaneous malignant melanoma (CMM) is currently the most fatal of skin cancers accounting for 50000 deaths annually. Five distinct melanomas are described histopathologically: superficial spreading, lentigo maligna, nodular, acral lentiginous and mucosal melanoma. The aim of this study was to investigate the characteristics of patients with various types of malignant melanoma and evaluate histopathological findings. In this retrospective study, we obtained our data from the records of 111 patients with melanoma...
May 2017: Acta Medica Iranica
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