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https://www.readbyqxmd.com/read/28230629/point-of-injury-tourniquet-application-during-operation-protective-edge-what-de-we-learn
#1
Amir Shlaifer, Avraham Yitzhak, Erez N Baruch, Avi Shina, Alexandra Satanovsky, Amiram Shovali, Ofer Almog, Elon Glassberg
BACKGROUND: Hemorrhage is a leading cause of preventable death on the battlefield. Timely tourniquet application to massively bleeding extremity wounds is critical for casualty survival albeit with reported adverse effects to extremity integrity. The aim of this study was to describe the immediate and short term outcomes of point of injury (POI) tourniquet applications during 'Operation Protective Edge' (OPE). METHODS: A case series study regarding tourniquet application at the POI during OPE was collected...
February 23, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28230291/therapeutic-potentials-of-bdnf-trkb-in-breast-cancer-current-status-and-perspectives
#2
Amir Tajbakhsh, Amin Mokhtari-Zaer, Mehdi Rezaee, Fahimeh Afzaljavan, Mehdi Rivandi, Seyed Mahdi Hassanian, Gordon A Ferns, Alireza Pasdar, Amir Avan
Brain-derived neurotrophic factor (BDNF) is a potent neurotrophic factor that has been shown to stimulate breast cancer cell growth and metastasis via tyrosine kinase receptors TrkA, TrkB and the p75(NTR) death receptor. The aberrant activation of BDNF/TrkB pathways can modulate several signaling pathways, including Akt/PI3K, Jak/STAT, NF-kB, UPAR/UPA, Wnt/β-catenin and VEGF pathways as well as the ER receptor. Several microRNAs have been identified that are involved in the modulation of BDNF/TrkB pathways...
February 23, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28230287/therapeutic-potential-of-targeting-pi3k-akt-pathway-in-treatment-of-colorectal-cancer-rational-and-progress
#3
Afsane Bahrami, Majid Khazaei, Malihe Hasanzadeh, Soodabeh ShahidSales, Mona Joudi Mashhad, Marjaneh Farazestanian, Hamid Reza Sadeghnia, Majid Rezayi, Mina Maftouh, Seyed Mahdi Hassanian, Amir Avan
PI3K/AKT/mTOR signaling pathway is one of the key dysregulated pathways in different tumor types, including colorectal cancer (CRC). Activation of this pathway is shown to be related with cellular transformation, tumor progression, cell survival and drug resistance. There is growing body of data evaluating the value of PI3K/AKT/mTOR inhibitors in CRC (e.g., BEZ235, NVP-BEZ235, OSI-027, everolimus, MK-2206, KRX-0401, BYL719 and BKM120). This report summarizes the current knowledge about PI3K/AKT pathway and its cross talk with ERK/MAPK and mTOR pathways with particular emphasis on the value of targeting this pathway as a potential therapeutic target in treatment of colorectal cancer...
February 23, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28230188/3d-time-lapse-imaging-and-quantification-of-mitochondrial-dynamics
#4
Miguel Sison, Sabyasachi Chakrabortty, Jérôme Extermann, Amir Nahas, Paul James Marchand, Antonio Lopez, Tanja Weil, Theo Lasser
We present a 3D time-lapse imaging method for monitoring mitochondrial dynamics in living HeLa cells based on photothermal optical coherence microscopy and using novel surface functionalization of gold nanoparticles. The biocompatible protein-based biopolymer coating contains multiple functional groups which impart better cellular uptake and mitochondria targeting efficiency. The high stability of the gold nanoparticles allows continuous imaging over an extended time up to 3000 seconds without significant cell damage...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28230054/magnetization-switching-in-ferromagnets-by-adsorbed-chiral-molecules-without-current-or-external-magnetic-field
#5
Oren Ben Dor, Shira Yochelis, Anna Radko, Kiran Vankayala, Eyal Capua, Amir Capua, See-Hun Yang, Lech Tomasz Baczewski, Stuart Stephen Papworth Parkin, Ron Naaman, Yossi Paltiel
Ferromagnets are commonly magnetized by either external magnetic fields or spin polarized currents. The manipulation of magnetization by spin-current occurs through the spin-transfer-torque effect, which is applied, for example, in modern magnetoresistive random access memory. However, the current density required for the spin-transfer torque is of the order of 1 × 10(6) A·cm(-2), or about 1 × 10(25) electrons s(-1) cm(-2). This relatively high current density significantly affects the devices' structure and performance...
February 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28229910/optimized-energy-of-spectral-ct-for-infarct-imaging-experimental-validation-with-human-validation
#6
Veit Sandfort, Srikanth Palanisamy, Rolf Symons, Amir Pourmorteza, Mark A Ahlman, Kelly Rice, Tom Thomas, Cynthia Davies-Venn, Bernhard Krauss, Alan Kwan, Ankur Pandey, Stefan L Zimmerman, David A Bluemke
OBJECTIVES: Late contrast enhancement visualizes myocardial infarction, but the contrast to noise ratio (CNR) is low using conventional CT. The aim of this study was to determine if spectral CT can improve imaging of myocardial infarction. MATERIALS AND METHODS: A canine model of myocardial infarction was produced in 8 animals (90-min occlusion, reperfusion). Later, imaging was performed after contrast injection using CT at 90 kVp/150 kVpSn. The following reconstructions were evaluated: Single energy 90 kVp, mixed, iodine map, multiple monoenergetic conventional and monoenergetic noise optimized reconstructions...
February 11, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28229570/the-periodization-of-resistance-training-in-soccer-players-changes-in-maximal-strength-lower-extremity-power-body-composition-and-muscle-volume
#7
Amir Barjaste, Bahman Mirzaei
BACKGROUND: The purpose of this study was to investigate the effect of 12-weeks traditional periodized resistance training on some physical capacities of soccer players. METHODS: Eighteen amateur soccer players with very little experience in resistance training voluntarily participated in this study. Subjects were assigned into two groups; Experimental (EX) group (n: 10) that conducted a traditional linear periodized resistance training program and a control (C) group (n: 8) that did not participate in any resistance training...
22, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28229351/the-relationship-between-religious-coping-and-self-care-behaviors-in-iranian-medical-students
#8
Hamid Sharif Nia, Saeed Pahlevan Sharif, Amir Hossein Goudarzian, Kelly A Allen, Saman Jamali, Mohammad Ali Heydari Gorji
In recent years, researchers have identified that coping strategies are an important contributor to an individual's life satisfaction and ability to manage stress. The positive relationship between religious copings, specifically, with physical and mental health has also been identified in some studies. Spirituality and religion have been discussed rigorously in research, but very few studies exist on religious coping. The aim of this study was to determine the relationship between religious coping methods (i...
February 22, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28228918/nutritional-composition-of-fruits-selected-by-long-tailed-macaques-macaca-fascicularis-in-kuala-selangor-malaysia
#9
Norazila Kassim, Kamarul Hambali, Aainaa Amir
Proximate analysis of twelve species of fruits commonly consumed by long-tailed macaques (Macaca fascicularis), i.e., Arenga pinnata, Areca catechu, Terminalia catappa, Elaeis guineensis, Lagerstroemia tomentosa, Mangifera indica, Cascabela thevetia, Muntingia calabura, Musa sp., Artocarpus heterophyllus, Ficus tinctoria ssp. gibbosa and Ficus microcarpa, was conducted with the specific objective to determine the nutritional composition of the foodstuffs of long-tailed macaques. The results showed the following order of nutrients: fibre, protein, fat and ash...
January 2017: Tropical Life Sciences Research
https://www.readbyqxmd.com/read/28228892/metastatic-extrapleural-malignant-solitary-fibrous-tumor-presenting-with-hypoglycemia-doege-potter-syndrome
#10
Andrew J Degnan, Kenneth K W Lee, Marta I Minervini, Amir A Borhani
We report a rare case of metastatic malignant solitary fibrous tumor (SFT) that presented with hypoglycemia because of insulin growth factor-2 production. Initial workup included computed tomography imaging that revealed a large, partially necrotic liver mass, a hypervascular pancreatic head lesion, and 2 renal lesions. Following hepatic resection, pancreatic head resection and nephrectomy, all these lesions demonstrated pathological findings that were consistent with SFT. The patient also had a history of an intracranial mass that had been previously resected and treated with gamma knife therapy at an outside institution, which was found to also be SFT...
March 2017: Radiology case reports
https://www.readbyqxmd.com/read/28228724/drug-utilization-on-neonatal-wards-a-systematic-review-of-observational-studies
#11
Rosliana Rosli, Ahmad Fauzi Dali, Noorizan Abd Aziz, Amir Heberd Abdullah, Long Chiau Ming, Mohamed Mansor Manan
Despite limited evidence on safety and efficacy of drug use in neonates, drugs are extensively used in this age group. However, the availability of information on drug consumption in neonates, especially inpatient neonates, is limited. This paper systematically reviews published studies on drug utilization in hospitalized neonates. A systematic literature review was carried out to identify observational studies published from inception of databases used till August 2016. Four search engines, namely Medline, CINAHL, Embase, and PubMed, were used...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28228050/is-neck-massage-safe-a-rare-case-of-tetraplegia-and-spinal-shock-after-neck-manipulation
#12
Tan Han Ling, Amir Fariz Bin Zakaria, Ahmad Tajuddin Bin Abdullah
Neck manipulation is associated with spinal cord injury. However, occurrence of such cases is infrequent. This article presents a 33-year-old gentleman who sustained acute tetraplegia after neck manipulation. The aim of this case report is to create awareness that vigorous neck manipulation could cause injury to the spinal cord.
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28227987/incorporating-shape-prior-into-active-contours-with-a-sparse-linear-combination-of-training-shapes-application-to-corpus-callosum-segmentation
#13
Mohammad M Farhangi, Hichem Frigui, Robert Bert, Amir A Amini, Mohammad M Farhangi, Hichem Frigui, Robert Bert, Amir A Amini, Robert Bert, Mohammad M Farhangi, Amir A Amini, Hichem Frigui
In this paper, a novel method of embedding shape information into level set image segmentation is proposed. Our method is based on inferring shape variations by a sparse linear combination of instances in the shape repository. Given a sufficient number of training shapes with variations, a new shape can be approximated by a linear span of training shapes associated with those variations. At each step of curve evolution the curve is moved to minimize Chan-Vese energy functional as well as toward the best approximation based on a linear combination of training samples...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227835/multi-chip-dataflow-architecture-for-massive-scale-biophysically-accurate-neuron-simulation
#14
Jaco Hofmann, Amir Zjajo, Carlo Galuzzi, Rene van Leuken, Jaco Hofmann, Amir Zjajo, Carlo Galuzzi, Rene van Leuken, Carlo Galuzzi, Rene Van Leuken, Jaco Hofmann, Amir Zjajo
State-of-the-art neuron simulators are capable of simulating at most few tens/hundreds of neurons in real-time due to the exponential growth in the communication costs with the number of simulated neurons. In this paper, we present a novel, reconfigurable, multi-chip system architecture based on localized communication, which effectively reduces the communication cost to a linear growth. The system is very flexible and it allows to tune, at run-time, various parameters, e.g. the intracellular concentration of chemical compounds, the interconnection scheme between the neurons...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227715/bivariate-autoregressive-state-space-modeling-of-psychophysiological-time-series-data
#15
Daniel M Smith, Mohammadreza Abtahi, Amir Mohammad Amiri, Kunal Mankodiya, Daniel M Smith, Mohammadreza Abtahi, Amir Mohammad Amiri, Kunal Mankodiya, Kunal Mankodiya, Daniel M Smith, Mohammadreza Abtahi, Amir Mohammad Amiri
Heart rate (HR) and electrodermal activity (EDA) are often used as physiological measures of psychological arousal in various neuropsychology experiments. In this exploratory study, we analyze HR and EDA data collected from four participants, each with a history of suicidal tendencies, during a cognitive task known as the Paced Auditory Serial Addition Test (PASAT). A central aim of this investigation is to guide future research by assessing heterogeneity in the population of individuals with suicidal tendencies...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227591/an-inductive-narrow-pulse-rfid-telemetry-system-for-gastric-slow-waves-monitoring
#16
Amir Javan-Khoskholgh, Zaid Abukhalaf, Ji Li, Larry S Miller, Mehdi Kiani, Aydin Farajidavar, Amir Javan-Khoskholgh, Zaid Abukhalaf, Ji Li, Larry S Miller, Mehdi Kiani, Aydin Farajidavar, Larry S Miller, Amir Javan-Khoskholgh, Ji Li, Mehdi Kiani, Zaid Abukhalaf
We present a passive data telemetry system for real-time monitoring of gastric electrical activity of a living subject. The system is composed of three subsystems: an implantable unit (IU), a wearable unit (WU), and a stationary unit (SU). Data communication between the IU and WU is based on a radio-frequency identification (RFID) link operating at 13.56 MHz. Since wireless power transmission and reverse data telemetry system share the same inductive interface, a load shift keying (LSK)-based differential pulse position (DPP) coding data communication with only 6...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227373/comparative-study-of-texture-features-in-oct-images-at-different-scales-for-human-breast-tissue-classification
#17
Yu Gan, Xinwen Yao, Ernest Chang, Syed Bin Amir, Hanina Hibshoosh, Sheldon Feldman, Christine P Hendon, Yu Gan, Xinwen Yao, Ernest Chang, Syed Bin Amir, Hanina Hibshoosh, Sheldon Feldman, Christine P Hendon, Syed Bin Amir, Christine P Hendon, Sheldon Feldman, Yu Gan, Hanina Hibshoosh, Ernest Chang, Xinwen Yao
Breast cancer is the second leading cause of death in women in the United States due to cancer. Early detection of breast cancerous regions will aid the diagnosis, staging, and treatment of breast cancer. Optical coherence tomography (OCT), a non-invasive imaging modality with high resolution, has been widely used to visualize various tissue types within the human breast and has demonstrated great potential for assessing tumor margins. Imaging large resected samples with a fast imaging speed can be accomplished by under-sampling in the spatial domain, resulting in a large image scale...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227119/clinical-viability-of-carotid-plaque-strain-estimation-using-b-mode-ultrasound-image-sequences
#18
Amir A Khan, Joseph C Hecker, Brajesh K Lal, Siddhartha Sikdar, Amir A Khan, Joseph C Hecker, Brajesh K Lal, Siddhartha Sikdar, Siddhartha Sikdar, Brajesh K Lal, Amir A Khan, Joseph C Hecker
It is estimated that approximately 30% of ischemic strokes are caused by rupture of plaque in the carotid artery. Development of techniques focusing on identifying plaques that are vulnerable to rupture is thus indispensable for stroke prevention. Recent studies have demonstrated that motion analysis of plaques from B-mode and RF ultrasound (US) image sequences can be used to estimate plaque strain. However, viability of these methods in a clinical setting, with variable acquisition protocols, has not been demonstrated yet...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226866/fully-implantable-multi-channel-microstimulator-with-tracking-supply-ribbon-and-energy-recovery
#19
Amin Rashidi, Niloofar Yazdani, Amir M Sodagar, Amin Rashidi, Niloofar Yazdani, Amir M Sodagar, Amir M Sodagar, Amin Rashidi, Niloofar Yazdani
This paper proposes a novel energy-efficient approach dedicated to high-density implantable stimulators such as visual prostheses. Energy efficiency of the approach proposed in this work is achieved through two ideas: the `tracking supply ribbon' technique, and `reverse charge pumping'. The proposed approach is implemented, in the multichannel case, in such a way that power efficiency of each stimulation channel is enhanced according to its specific voltage/current condition and independently from other channels...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226737/4d-lung-tumor-segmentation-via-shape-prior-and-motion-cues
#20
Jung Won Cha, Mohammad M Farhangi, Neal Dunlap, Amir Amini, Jung Won Cha, Mohammad M Farhangi, Neal Dunlap, Amir Amini, Jung Won Cha, Amir Amini, Neal Dunlap, Mohammad M Farhangi
Lung tumor segmentation is important for therapy in the radiation treatment of patients with thoracic malignancies. In this paper, we describe a 4D image segmentation method based on graph-cuts optimization, shape prior and optical flow. Due to small size, the location, and low contrast between the tumor and the surrounding tissue, tumor segmentation in 3D+t is challenging. We performed 4D lung tumor segmentation in 5 patients, and in each case compared the results with the expert-delineated lung nodules. In each case, 4D image segmentation took approximately ten minutes on a PC with AMD Phenom II and 32GB of memory for segmenting tumor in five phases of lung CT data...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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