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https://www.readbyqxmd.com/read/29779296/the-assessment-and-management-of-chest-pain-in-primary-care-a-focus-on-acute-coronary-syndrome
#1
Richard Thomsett, Louise Cullen
BACKGROUND: Chest pain is a common presentation and diagnosis can be challenging. There are many causes for chest pain, including life-threatening conditions such as acute coronary syndrome (ACS), which can prove difficult to diagnose. OBJECTIVE: This article focuses on diagnosis and early management of patients with possible ACS. Key differentials and essential primary care investigations and management are outlined. Hospital-based risk stratification and management are described, providing an outline of what patients can expect if referred to hospital...
May 2018: Australian journal of general practice
https://www.readbyqxmd.com/read/29779266/associations-of-mental-health-with-cardiovascular-risk-phenotypes-and-adiposity-in-adolescence-a-cross-sectional-community-based-study
#2
Kate Lycett, Clare McNamara, Fiona K Mensah, David Burgner, Jessica A Kerr, Josh Muller, Melissa Wake
AIM: Cardiovascular disease and mental illness commonly co-occur in later life, but it is unknown how early these associations arise. We aimed to determine the extent to which: (i) childhood mental health is associated with functional and structural cardiovascular risk phenotypes and adiposity in late childhood/adolescence, and (ii) associations between mental health and cardiovascular phenotypes may be explained by differential body mass index. METHODS: This cross-sectional study drew on three longitudinal community-based cohort studies (two enriched for overweight/obesity) in metropolitan Melbourne, Australia, with harmonized follow-up in 2014...
May 20, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29779257/linking-seed-germination-and-plant-height-a-case-study-of-a-wetland-community-on-the-eastern-tibet-plateau
#3
Kun Liu, Suzhen Cao, Guozhen Du, Jerry M Baskin, Carol C Baskin, Haiyan Bu, Wei Qi, Ting Liang
Seed germination is the earliest trait expressed in a plant's life history, and it can directly affect the expression of post germination traits. Plant height is central to plant ecological strategies, because it is a major determinant of the ability of a species to compete for light. Thus, linking seed germination and plant height at the community level is very important to understanding plant fitness and community structure. Here, we tested storage condition and temperature requirements for germination of 31 species from a wetland plant community on the eastern Tibet Plateau, and analyzed correlation of germination traits with plant height in relation to storage condition...
May 20, 2018: Plant Biology
https://www.readbyqxmd.com/read/29779252/germination-niche-breadth-varies-inconsistently-among-three-asclepias-congeners-along-a-latitudinal-gradient
#4
Jessamine Finch, Jeffrey L Walck, Siti N Hidayati, Andrea T Kramer, Victoria Lason, Kayri Havens
Species responses to climate change will be primarily driven by their environmental tolerance range, or niche breadth, with the expectation that broad niches will increase resilience. Niche breadth is expected to be greater in more heterogeneous environments and moderated by life history. Niche breadth also varies across life stage. Therefore, the life stage with the narrowest niche may serve as the best predictor of climatic vulnerability. To investigate the relationship between niche breadth, climate, and life stage we identify germination niche breadth for dormant and nondormant seeds in multiple populations of three milkweed (Asclepias) species...
May 20, 2018: Plant Biology
https://www.readbyqxmd.com/read/29779237/enzyme-free-replication-with-two-or-four-bases
#5
Clemens Richert, Elena Hänle
All known forms of life encode their genetic information in a sequence of bases of a genetic polymer and produce copies of their genes via semiconservative replication. How this process started before polymerase enzymes had been evolved is unclear. Enzyme-free copying of short stretches of DNA or RNA sequence has been demonstrated, using activated nucleotides, but not replication. We have developed a methodology for replication. It involves extension with reversible termination, enzyme-free ligation, and strand capture and allowed us to monitor nucleotide incorporation for an entire helical turn of DNA, both during a first and a second round of copying...
May 20, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29779204/hypertensive-disorders-of-pregnancy-and-subsequent-maternal-cardiovascular-health
#6
Nienke E Bergen, Sarah Schalekamp-Timmermans, Jolien Roos-Hesselink, Jeanine E Roeters van Lennep, Vincent V W Jaddoe, Eric A P Steegers
To examine associations between hypertensive pregnancy disorders and maternal cardiovascular disease (CVD) in later life. We examined the associations between blood pressure (BP) in pregnancy, gestational hypertension (GH) and preeclampsia (PE) with cardiovascular measurements 6 years after index pregnancy among 4912 women participating in the Generation R Study, the Netherlands. BP, left ventricular mass (LV mass), aortic root diameter (AOD), left atrial diameter, fractional shortening, and carotid-femoral pulse wave velocity (PWV)...
May 19, 2018: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29779143/health-related-quality-of-life-in-coronary-heart-disease-a-systematic-review-and-meta-analysis-mapped-against-the-international-classification-of-functioning-disability-and-health
#7
REVIEW
Jana Le, Diana S Dorstyn, Elias Mpfou, Elise Prior, Phillip J Tully
BACKGROUND: Health-related quality of life (HRQoL) is an important outcome in coronary heart disease (CHD). However, variability in HRQoL indicators suggests a need to consider domain coverage. This review applies a globally accepted framework, the International Classification of Functioning, Disability and Health (ICF), to map HRQoL measures that are reliable and valid among people with CHD. METHODS: The Embase, Pubmed and PsycInfo databases were searched, with 10 observational studies comparing HRQOL among 4786 adults with CHD to 50949 controls identified...
May 19, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29779138/cognitive-syndromes-after-the-first-stroke
#8
Denisa Salihović, Dževdet Smajlović, Milija Mijajlović, Emina Zoletić, Omer Ć Ibrahimagić
AIM: The aim of this study is to determine impairments of certain cognitive functions in certain vascular cognitive syndromes and to identify predictors of dementia. PATIENTS AND METHODS: One-year prospective study included 275 patients, who were hospitalized at the Department of Neurology Tuzla and therefore fulfilled certain criteria. Patients were divided into following subgroups of vascular cognitive impairment (VCI): dementia of strategic infarct (DSI), cortical dementia (CD), sub cortical dementia (SCD), hemorrhagic dementia (HD), and patients without dementia...
May 19, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29779135/novel-evaluation-scale-for-qol-qol-acd-bp-in-preoperative-chemotherapy-for-breast-cancer
#9
Koji Takada, Shinichiro Kashiwagi, Wataru Goto, Yuka Asano, Katsuyuki Takahashi, Tamami Morisaki, Tsutomu Takashima, Shuhei Tomita, Kosei Hirakawa, Masaichi Ohira
PURPOSE: Quality-of-life (QOL) has been reported to affect the prognosis of many types of cancer, and several studies used various QOL assessment tools to determine the relationship between QOL and cancer prognosis. In this study, QOL-Questionnaire for Cancer Patients Treated with Anti-Cancer Drugs-the Breast (QOL-ACD-B) was modified to be suitable for preoperative chemotherapy (POC) and was named the QOL-ACD-BP. METHODS: A total of 300 patients were treated with POC after being diagnosed with breast cancer between February 2007 and December 2016 at our institute...
May 19, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29779117/how-common-is-balkan-endemic-nephropathy-among-immigrants-in-endemic-regions
#10
Ljubica Đukanović, Maja Račić, Ivko Marić, Zlatko Maksimović, Jelena Simić, Jela Aleksić, Sanja Stanković, Vesna Pejović, Višnja Ležaić
PURPOSE: In the early 1970s, a number of authors described the development of Balkan endemic nephropathy (BEN) in immigrants in endemic regions. The aim of this study was to examine whether immigrants in endemic regions are suffering from BEN today. METHODS: The study involved 193 residents of two endemic regions divided into three groups: two groups of native residents-(1) members of BEN families, (2) members of non-BEN families, and (3) immigrants, who had moved from non-affected settlements to the endemic regions of Kolubara (38 years ago) or Semberia (20 years ago)...
May 19, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29779032/kidney-disease-in-women-is-associated-with-disadvantaged-childhood-socioeconomic-position
#11
Mark Canney, Siobhan Leahy, Siobhan Scarlett, Rose Anne Kenny, Mark A Little, Conall M O'Seaghdha, Cathal McCrory
BACKGROUND: Socioeconomic position (SEP) is an important determinant of health and it is dynamic across the entire lifespan. We sought to investigate the relationship between life-course SEP and chronic kidney disease (CKD) using 3 conceptual models: critical period, pathway and accumulation. METHODS: Cross-sectional analysis of 4,996 participants from The Irish Longitudinal Study on Ageing, a nationally representative cohort of community-dwelling adults aged ≥50 years...
May 18, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29779024/a-randomized-clinical-trial-of-metformin-to-treat-autosomal-dominant-polycystic-kidney-disease
#12
Stephen L Seliger, Kaleab Z Abebe, Kenneth R Hallows, Dana C Miskulin, Ronald D Perrone, Terry Watnick, Kyongtae Tae Bae
BACKGROUND: Metformin inhibits cyclic AMP generation and activates AMP-activated protein kinase (AMPK), which inhibits the cystic fibrosis transmembrane conductance regulator and Mammalian Target of Rapamycin pathways. Together these effects may reduce cyst growth in autosomal dominant polycystic kidney disease (ADPKD). METHODS: A phase II, double-blinded randomized placebo-controlled trial of 26 months duration. Participants will include nondiabetic adults (n = 96) aged 18-60 years, with an estimated glomerular filtration rate (eGFR) ≥50 mL/min/1...
May 18, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29779020/acetaminophen-reduces-acute-and-persistent-incisional-pain-after-hysterectomy
#13
Onur Koyuncu, Sedat Hakimoglu, Mustafa Ugur, Cagla Akkurt, Selim Turhanoglu, Daniel Sessler, Alparslan Turan
OBJECTIVE: Acetaminophen is effective for acute surgical pain, but whether it reduces persistent incision pain remains unknown. We tested the primary hypothesis that patients given perioperative acetaminophen have less incisional pain three months after surgery. Our secondary hypotheses were that patients randomized to acetaminophen have less postoperative pain and analgesic consumption, and better functional recovery at three months. METHODS: 140 patients having abdominal hysterectomy were randomly assigned to: 1)intravenous acetaminophen (4 g/day for 72 postoperative hours); or, 2) saline placebo...
May 15, 2018: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29778976/developing-two-reference-control-samples-for-the-indian-population
#14
Shruti Iyer, Priyanka Bhatia, Mahendra Rao, Odity Mukherjee
Human induced Pluripotent Stem Cells (HiPSCs) have immense potential in research and therapeutics. Under the aegis of Department of Biotechnology funded national program entitled, "The Accelerator program for Discovery in Brain Disorders using Stem Cells (ADBS)" we have established a HiPSC biorepository (https://www.ncbs.res.in/adbs/bio-repository) with an objective to study severe mental illness. The repository comprises of HiPSC lines derived from healthy control donors and individuals with life time diagnosis of severe mental illness from dense families...
May 12, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29778969/social-support-under-siege-an-analysis-of-forced-migration-among-women-from-the-democratic-republic-of-congo
#15
Karin Wachter, Lauren E Gulbas
In 2016, researchers conducted a qualitative study in a mid-sized town in the United States to address gaps in research and practice related to psychosocial consequences of forced migration among women. The loss of social support and its impacts on the well-being of women are rarely addressed in refugee resettlement policy or practice overwhelmingly concerned with economic self-sufficiency. The study sought to develop theory to explain how women (n = 27) who migrated from the Democratic Republic of the Congo recreate social support post-resettlement in the United States...
May 3, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29778956/health-risk-assessment-of-heavy-metals-in-atmospheric-deposition-in-a-congested-city-environment-in-a-developing-country-kandy-city-sri-lanka
#16
Lakshika Weerasundara, D N Magana-Arachchi, Abdul M Ziyath, Ashantha Goonetilleke, Meththika Vithanage
This research study which was undertaken in a congested city environment in a developing country provides a robust approach for the assessment and management of human health risk associated with atmospheric heavy metals. The case study area was Kandy City, which is the second largest city in Sri Lanka and bears the characteristics of a typical city in the developing world such as the urban footprint, high population density and traffic congestion. Atmospheric deposition samples were collected on a weekly basis and analyzed for nine heavy metals common to urban environments, namely, Al, Cr, Mn, Fe, Ni, Cu, Zn, Cd and Pb...
May 17, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29778942/transcriptomic-and-methylomic-analysis-reveal-the-toxicological-effect-of-2-3-7-8-tetrachlorodibenzodioxin-on-human-embryonic-stem-cell
#17
Keng Po Lai, Jing Woei Li, Ting Fung Chan, Andy Chen, Cherie Yin Lau Lee, William Shu Biu Yeung, Chris Kong Chu Wong
Cumulating epidemiological studies demonstrated that environmental exposure to endocrine disrupting chemicals (EDCs) during the early stages of fetal development is associated with the increase in disease susceptibility in later life. The fetal developmental plasticity is considered as a protective mechanism against an undesirable prenatal environment. Dioxin is one of the environmental contaminants and is considered a diabetogenic factor. Experimental animal and human epidemiological studies have revealed that dioxin exposure was associated with insulin resistance and altered beta cell function...
May 10, 2018: Chemosphere
https://www.readbyqxmd.com/read/29778897/measurement-of-ambient-dose-equivalent-rates-by-walk-survey-around-fukushima-dai-ichi-nuclear-power-plant-using-kurama-ii-until-2016
#18
Masaki Andoh, Hideaki Yamamoto, Takashi Kanno, Kimiaki Saito
Ambient dose equivalent rates in various environments related to human lives were measured by walk surveys using the KURAMA-II systems from 2013 to 2016 within an 80-km radius of the Fukushima Dai-ichi Nuclear Power Plant. The dose rate of the locations where the walk survey was performed decreased to about 38% of its initial value in the 42 months from June 2013 to the December 2016, which was beyond that attributable to the physical decay of radiocaesium. The ecological half-life of the slow decreasing component was evaluated to be 4...
May 17, 2018: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29778861/multicenter-randomized-controlled-crossover-trial-comparing-hemodynamic-optimization-against-echocardiographic-optimization-of-av-and-vv-delay-of-cardiac-resynchronization-therapy-the-bravo-trial
#19
Zachary I Whinnett, S M Afzal Sohaib, Mark Mason, Edward Duncan, Mark Tanner, David Lefroy, Mohamed Al-Obaidi, Sue Ellery, Francisco Leyva-Leon, Tim Betts, Mark Dayer, Paul Foley, Jon Swinburn, Martin Thomas, Raj Khiani, Tom Wong, Zaheer Yousef, Dominic Rogers, Paul R Kalra, Vignesh Dhileepan, Katherine March, James Howard, Andreas Kyriacou, Jamil Mayet, Prapa Kanagaratnam, Michael Frenneaux, Alun D Hughes, Darrel P Francis
OBJECTIVES: BRAVO (British Randomized Controlled Trial of AV and VV Optimization) is a multicenter, randomized, crossover, noninferiority trial comparing echocardiographic optimization of atrioventricular (AV) and interventricular delay with a noninvasive blood pressure method. BACKGROUND: Cardiac resynchronization therapy including AV delay optimization confers clinical benefit, but the optimization requires time and expertise to perform. METHODS: This study randomized patients to echocardiographic optimization or hemodynamic optimization using multiple-replicate beat-by-beat noninvasive blood pressure at baseline; after 6 months, participants were crossed over to the other optimization arm of the trial...
May 11, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29778837/defining-host-responses-during-systemic-bacterial-infection-through-construction-of-a-murine-organ-proteome-atlas
#20
John D Lapek, Robert H Mills, Jacob M Wozniak, Anaamika Campeau, Ronnie H Fang, Xiaoli Wei, Kirsten van de Groep, Araceli Perez-Lopez, Nina M van Sorge, Manuela Raffatellu, Rob Knight, Liangfang Zhang, David J Gonzalez
Group A Streptococcus (GAS) remains one of the top 10 deadliest human pathogens worldwide despite its sensitivity to penicillin. Although the most common GAS infection is pharyngitis (strep throat), it also causes life-threatening systemic infections. A series of complex networks between host and pathogen drive invasive infections, which have not been comprehensively mapped. Attempting to map these interactions, we examined organ-level protein dynamics using a mouse model of systemic GAS infection. We quantified over 11,000 proteins, defining organ-specific markers for all analyzed tissues...
April 28, 2018: Cell Systems
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