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https://www.readbyqxmd.com/read/28737742/systemic-transport-of-trans-zeatin-and-its-precursor-have-differing-roles-in-arabidopsis-shoots
#1
Asami Osugi, Mikiko Kojima, Yumiko Takebayashi, Nanae Ueda, Takatoshi Kiba, Hitoshi Sakakibara
Organ-to-organ signal transmission is essential for higher organisms to ensure coordinated biological reactions during metabolism and morphogenesis. Similar to organs in animals, plant organs communicate by various signalling molecules. Among them, cytokinins, a class of phytohormones, play a key role as root-to-shoot long-distance signals, regulating various growth and developmental processes in shoots(1,2). Previous studies have proposed that trans-zeatin-riboside, a type of cytokinin precursor, is a major long-distance signalling form in xylem vessels and its action depends on metabolic conversion via the LONELY GUY enzyme in proximity to the site of action(3-5)...
July 24, 2017: Nature Plants
https://www.readbyqxmd.com/read/28730904/occupational-therapists-awareness-of-guidelines-for-assessment-and-diagnosis-of-developmental-coordination-disorder-mesure-selon-laquelle-les-ergoth%C3%A3-rapeutes-connaissent-les-lignes-directrices-relatives-%C3%A3-l-%C3%A3-valuation-et-au-diagnostic-du-trouble-du-d%C3%A3-veloppement
#2
Morgan Karkling, Alissa Paul, Jill G Zwicker
BACKGROUND: Developmental coordination disorder (DCD) is a motor skills disorder that can have negative lifelong psychosocial impacts if not diagnosed. Occupational therapists have a role in facilitating a diagnosis for children with DCD through assessment. PURPOSE: The purpose of this study was to determine the level of understanding of current DCD guidelines for assessment and diagnosis among occupational therapists working in paediatric settings in British Columbia, Canada...
June 2017: Canadian Journal of Occupational Therapy. Revue Canadienne D'ergothérapie
https://www.readbyqxmd.com/read/28730897/intervention-and-management-of-developmental-coordination-disorder-are-we-providing-evidence-based-services-intervention-et-traitement-d-un-trouble-du-d%C3%A3-veloppement-de-la-coordination-les-ergoth%C3%A3-rapeutes-fournissent-ils-des-services-fond%C3%A3-s-sur-les-faits
#3
Renée Withers, Yoyo Tsang, Jill G Zwicker
BACKGROUND: Occupational therapists are well positioned to provide intervention to improve outcomes for children with developmental coordination disorder. However, little is known about what occupational therapy services are provided for these children. PURPOSE: As part of a larger study exploring service provision for children with developmental coordination disorder, the purpose of this study was to examine intervention and referral practices of occupational therapists in British Columbia, Canada...
June 2017: Canadian Journal of Occupational Therapy. Revue Canadienne D'ergothérapie
https://www.readbyqxmd.com/read/28725201/nature-and-specificity-of-gestural-disorder-in-children-with-developmental-coordination-disorder-a-multiple-case-study
#4
Orianne Costini, Arnaud Roy, Chrystelle Remigereau, Sylvane Faure, Catherine Fossoud, Didier Le Gall
Aim: Praxis assessment in children with developmental coordination disorder (DCD) is usually based on tests of adult apraxia, by comparing across types of gestures and input modalities. However, the cognitive models of adult praxis processing are rarely used in a comprehensive and critical interpretation. These models generally involve two systems: a conceptual system and a production system. Heterogeneity of deficits is consistently reported in DCD, involving other cognitive skills such as executive or visual-perceptual and visuospatial functions...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28714153/ripples-of-influence-professor-sylvia-rodger-s-contribution-to-the-body-of-knowledge-on-developmental-coordination-disorder
#5
Ann Kennedy-Behr
No abstract text is available yet for this article.
July 2017: Australian Occupational Therapy Journal
https://www.readbyqxmd.com/read/28711427/temporal-remodeling-of-the-cell-cycle-accompanies-differentiation-in-the-drosophila-germline
#6
Taylor D Hinnant, Arturo A Alvarez, Elizabeth T Ables
Development of multicellular organisms relies upon the coordinated regulation of cellular differentiation and proliferation. Growing evidence suggests that some molecular regulatory pathways associated with the cell cycle machinery also dictate cell fate; however, it remains largely unclear how the cell cycle is remodeled in concert with cell differentiation. During Drosophila oogenesis, mature oocytes are created through a series of precisely controlled division and differentiation steps, originating from a single tissue-specific stem cell...
July 12, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28710941/procedural-learning-in-parkinson-s-disease-specific-language-impairment-dyslexia-schizophrenia-developmental-coordination-disorder-and-autism-spectrum-disorders-a-second-order-meta-analysis
#7
Gillian M Clark, Jarrad A G Lum
The serial reaction time task (SRTT) has been used to study procedural learning in clinical populations. In this report, second-order meta-analysis was used to investigate whether disorder type moderates performance on the SRTT. Using this approach to quantitatively summarise past research, it was tested whether autism spectrum disorder, developmental coordination disorder, dyslexia, Parkinson's disease, schizophrenia, and specific language impairment differentially affect procedural learning on the SRTT. The main analysis revealed disorder type moderated SRTT performance (p=0...
October 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28707062/when-an-object-appears-unexpectedly-foot-placement-during-obstacle-circumvention-in-children-and-adults-with-developmental-coordination-disorder
#8
K Wilmut, A L Barnett
Adjustments to locomotion to avoid an obstacle require a change to the usual pattern of foot placement, i.e. changes to step length and/or step width. Previous studies have demonstrated a difficulty in individuals with Developmental Coordination Disorder (DCD) in controlling stability while both stepping over and while circumventing an obstacle. In a previous study, we have considered the way in which individuals with DCD prepare for the possibility of an obstacle appearing (Wilmut and Barnett in Exp Brain Res 235:1531-1340, 2017)...
July 13, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28707061/the-evolutionary-significance-of-pretend-play-two-year-olds-interpretation-of-behavioral-cues
#9
Lili Ma, Angeline S Lillard
Pretend play begins very early in human life. A key question is why, when figuring out reality is young children's major developmental task, they engage in its deliberate falsification. A second key question is how children know that pretend events are not real. Here we report three experiments addressing the latter question and providing indirect evidence for speculation on the first question. Children (N = 96) were shown actors eating or pretending to eat from covered bowls, and they had to indicate, on the basis of the actors' behavioral signs, which actor was pretending to eat or had the real food...
July 13, 2017: Learning & Behavior
https://www.readbyqxmd.com/read/28706281/thiamine-metabolism-is-critical-for-regulating-correlated-growth-of-dendrite-arbors-and-neuronal-somata
#10
Huimin Liu, Shaoming Sang, Yuan Lu, Zhongfeng Wang, Xiang Yu, Chunjiu Zhong
Thiamine is critical for cellular function, as its phosphorylated and active form, thiamine diphosphate (TDP), acts as coenzyme for three key enzymes in glucose metabolism. Mutations in thiamine transporter, TDP synthesizing enzyme or carrier, including solute carrier family 19 member 3 (SLC19A3), thiamine pyrophosphokinase (TPK1) and solute carrier family 25 member 19 (SLC25A19), have been associated with developmental neurological disorders, including microcephaly and Leigh syndrome. However, little is known about how thiamine metabolism regulates neuronal morphology at the cellular level...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28704379/fractionating-nonword-repetition-the-contributions-of-short-term-memory-and-oromotor-praxis-are-different
#11
Saloni Krishnan, Katherine J Alcock, Daniel Carey, Lina Bergström, Annette Karmiloff-Smith, Frederic Dick
The ability to reproduce novel words is a sensitive marker of language impairment across a variety of developmental disorders. Nonword repetition tasks are thought to reflect phonological short-term memory skills. Yet, when children hear and then utter a word for the first time, they must transform a novel speech signal into a series of coordinated, precisely timed oral movements. Little is known about how children's oromotor speed, planning and co-ordination abilities might influence their ability to repeat novel nonwords, beyond the influence of higher-level cognitive and linguistic skills...
2017: PloS One
https://www.readbyqxmd.com/read/28703361/non-decoupled-morphological-evolution-of-the-fore-and-hindlimb-of-sabretooth-predators
#12
Alberto Martín-Serra, Borja Figueirido, Paul Palmqvist
Specialized organisms are useful for exploring the combined effects of selection of functional traits and developmental constraints on patterns of phenotypic integration. Sabretooth predators are one of the most interesting examples of specialization among mammals. Their hypertrophied, sabre-shaped upper canines and their powerfully built forelimbs have been interpreted as adaptations to a highly specialized predatory behaviour. Given that the elongated and laterally compressed canines of sabretooths were more vulnerable to fracture than the shorter canines of conical-tooth cats, it has been long hypothesized that the heavily muscled forelimbs of sabretooths were used for immobilizing prey before developing a quick and precise killing bite...
July 12, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28703129/precise-inhibitory-microcircuit-assembly-of-developmentally-related-neocortical-interneurons-in-clusters
#13
Xin-Jun Zhang, Zhizhong Li, Zhi Han, Khadeejah T Sultan, Kun Huang, Song-Hai Shi
GABA-ergic interneurons provide diverse inhibitions that are essential for the operation of neuronal circuits in the neocortex. However, the mechanisms that control the functional organization of neocortical interneurons remain largely unknown. Here we show that developmental origins influence fine-scale synapse formation and microcircuit assembly of neocortical interneurons. Spatially clustered neocortical interneurons originating from low-titre retrovirus-infected radial glial progenitors in the embryonic medial ganglionic eminence and preoptic area preferentially develop electrical, but not chemical, synapses with each other...
July 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/28700717/integrated-analysis-of-zone-specific-protein-and-metabolite-profiles-within-nitrogen-fixing-medicago-truncatula-sinorhizobium-medicae-nodules
#14
Aaron J Ogden, Mahmoud Gargouri, JeongJin Park, David R Gang, Michael L Kahn
Symbiotic nitrogen fixation (SNF) between rhizobia and legumes requires metabolic coordination within specialized root organs called nodules. Nodules formed in the symbiosis between S. medicae and barrel medic (M. truncatula) are indeterminate, cylindrical, and contain spatially distinct developmental zones. Bacteria in the infection zone II (ZII), interzone II-III (IZ), and nitrogen fixation zone III (ZIII) represent different stages in the metabolic progression from free-living bacteria into nitrogen fixing bacteroids...
2017: PloS One
https://www.readbyqxmd.com/read/28698262/thyroid-hormone-coordinates-pancreatic-islet-maturation-during-the-zebrafish-larval-to-juvenile-transition-to-maintain-glucose-homeostasis
#15
Hiroki Matsuda, Sri Teja Mullapudi, Yuxi Zhang, Daniel Hesselson, Didier Y R Stainier
Thyroid hormone (TH) signaling promotes tissue maturation and adult organ formation. Developmental transitions alter an organism's metabolic requirements, and it remains unclear how development and metabolic demands are coordinated. We used the zebrafish as a model to test whether and how TH signaling affects pancreatic islet maturation, and consequently glucose homeostasis, during the larval to juvenile transition. We found that exogenous TH precociously activates the β cell differentiation genes pax6b and mnx1, while downregulating arxa, a master regulator of α cell development and function...
July 11, 2017: Diabetes
https://www.readbyqxmd.com/read/28697335/chk1-inhibition-of-the-replication-factor-drf1-guarantees-cell-cycle-elongation-at-the-xenopus-laevis-mid-blastula-transition
#16
Clara Collart, James C Smith, Philip Zegerman
The early cell divisions of many metazoan embryos are rapid and occur in the near absence of transcription. At the mid-blastula transition (MBT), the cell cycle elongates and several processes become established including the onset of bulk transcription and cell-cycle checkpoints. How these events are timed and coordinated is poorly understood. Here we show in Xenopus laevis that developmental activation of the checkpoint kinase Chk1 at the MBT results in the SCF(β-TRCP)-dependent degradation of a limiting replication initiation factor Drf1...
July 10, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28697314/grainyhead-like-transcription-factors-in-craniofacial-development
#17
M R Carpinelli, M E de Vries, S M Jane, S Dworkin
Craniofacial development in vertebrates involves the coordinated growth, migration, and fusion of several facial prominences during embryogenesis, processes governed by strict genetic and molecular controls. A failure in any of the precise spatiotemporal sequences of events leading to prominence fusion often leads to anomalous facial, skull, and jaw formation-conditions termed craniofacial defects (CFDs). Affecting approximately 0.1% to 0.3% of live births, CFDs are a highly heterogeneous class of developmental anomalies, which are often underpinned by genetic mutations...
July 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28691167/exploring-the-link-between-visual-perception-visual-motor-integration-and-reading-in-normal-developing-and-impaired-children-using-dtvp-2
#18
Stéphanie Bellocchi, Mathilde Muneaux, Andréa Huau, Yohana Lévêque, Marianne Jover, Stéphanie Ducrot
Reading is known to be primarily a linguistic task. However, to successfully decode written words, children also need to develop good visual-perception skills. Furthermore, motor skills are implicated in letter recognition and reading acquisition. Three studies have been designed to determine the link between reading, visual perception, and visual-motor integration using the Developmental Test of Visual Perception version 2 (DTVP-2). Study 1 tests how visual perception and visual-motor integration in kindergarten predict reading outcomes in Grade 1, in typical developing children...
July 10, 2017: Dyslexia: the Journal of the British Dyslexia Association
https://www.readbyqxmd.com/read/28687624/patellins-are-regulators-of-auxin-mediated-pin1-relocation-and-plant-development-in-arabidopsis-thaliana
#19
Ricardo Tejos, Cecilia Rodriguez-Furlan, Maciej Adamowski, Michael Sauer, Lorena Norambuena, Jiří Friml
Coordinated cell polarization in developing tissues is a recurrent theme in multicellular organisms. In plants, a directional distribution of the plant hormone auxin is at the core of many developmental programs. A feedback regulation of auxin on the polarized localization of PIN auxin transporters in individual cells has been proposed as a self-organizing mechanism for coordinated tissue polarization, but the molecular mechanisms linking auxin signalling to PIN-dependent auxin transport remain unknown. We performed a microarray-based approach to find regulators of the auxin-induced PIN relocation in the Arabidopsis thaliana root...
July 7, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28687557/a-pif1-pif3-hy5-bbx23-transcription-factor-cascade-affects-photomorphogenesis
#20
Xinyu Zhang, Fangfang Shang, Junling Huai, Gang Xu, Weijiang Tang, Yanjun Jing, Rongcheng Lin
Light signaling plays an essential role in controlling higher plants' early developmental process termed as photomorphogenesis. Transcriptional regulation is a vital mechanism that is orchestrated by transcription factors and other regulatory proteins working in concert to finely tune gene expression. Although many transcription factors/regulators have been characterized in the light signaling pathway, their inter-regulation remains largely unknown. Here, we show that PHYTOCHROME-INTERACTING FACTOR 3 (PIF3) and PIF1 transcription factors directly bind to the regulatory regions of ELONGATED HYPOCOTYL5 (HY5) and a B-box gene BBX23 and activate their expression in Arabidopsis thaliana...
July 7, 2017: Plant Physiology
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