keyword
MENU ▼
Read by QxMD icon Read
search

Reject

keyword
https://www.readbyqxmd.com/read/28535529/looking-into-the-graft-without-a-biopsy-biomarkers-of-acute-rejection-in-renal-transplantation
#1
Andrea Angeletti, Paolo Cravedi
Immunosuppression in kidney transplantation is still largely driven by center-specific protocols and adjusted according to the presence of graft dysfunction, drug toxicity or infection. Due to the current inability to titrate immunosuppression to the needs of every single patient, this approach is burdened by an increased risk of under or over-immunosuppression. To extend allograft survival, immunosuppression should be decided based on reliable biomarkers capable of quantifying the alloimmune response and/or noninvasively diagnosing acute rejection...
2017: Contributions to Nephrology
https://www.readbyqxmd.com/read/28535528/chronic-allograft-injury-an-overview-of-pathogenesis-and-treatment-strategies
#2
Hector M Madariaga, Leonardo V Riella
Chronic allograft injury (CAI) remains one of the biggest challenges in transplantation as it directly affects the long-term allograft survival, an area in which the scientific and transplantation communities have struggled to improve outcomes. Therefore, understanding the mechanisms of CAI is paramount to implement preventive measures and novel therapeutic options. In this review, we will address the latest evidence on CAI, potential etiologies and risk factors including non-adherence, antibody-mediated rejection, recurrence of glomerular disease, BK nephropathy, and calcineurin nephrotoxicity...
2017: Contributions to Nephrology
https://www.readbyqxmd.com/read/28535527/treatment-of-acute-antibody-mediated-rejection
#3
Giorgia Comai, Matteo Ravaioli, Olga Baraldi, Vania Cuna, Lorenzo Gasperoni, Giovanni Liviano D''Arcangelo, Maria Cappuccilli, Antonio D Pinna, Claudio Ronco, Gaetano La Manna
Acute antibody-mediated rejection (AMR) remains an important challenge in the field of kidney transplantation despite the advances in immunosuppressive strategies, and has been recognized as an important cause of allograft dysfunction and graft loss. The treatments of acute AMR are not standardized and poor evidence is currently available on the effectiveness of therapy regimens with combinations of drugs. Standard treatment for acute AMR is based on 3 cornerstones: removal of donor-specific antibodies (DSAs) from the bloodstream, reduction of DSAs synthesis, and inhibition of the interaction between DSAs and human leukocyte antigen antigens on donor's cells...
2017: Contributions to Nephrology
https://www.readbyqxmd.com/read/28535433/a-highly-selective-surface-coating-for-enhanced-membrane-rejection-of-endocrine-disrupting-compounds-mechanistic-insights-and-implications
#4
Hao Guo, Yu Deng, Zhikan Yao, Zhe Yang, Jianqiang Wang, Chuner Lin, Tong Zhang, Baoku Zhu, Chuyang Y Tang
We designed a highly selective surface coating to achieve enhanced rejection of endocrine disrupting compounds (EDCs) by nanofiltration membranes. A commercial NF90 membrane was first coated with polydopamine (PDA) followed by in situ immobilization of silver nanoparticles (AgNPs). This PDA/AgNPs coating greatly improved EDC rejection at the expense of slight water permeability loss (4-10%). This improvement in rejection can be attributed to a combination of enhanced size exclusion and suppressed hydrophobic interaction...
May 18, 2017: Water Research
https://www.readbyqxmd.com/read/28534231/comparison-of-outcomes-and-complications-of-deep-anterior-lamellar-keratoplasty-and-penetrating-keratoplasty-performed-in-a-large-group-of-patients-with-keratoconus
#5
Ashbala Khattak, Fouad R Nakhli, Khaled M Al-Arfaj, Abdullah A Cheema
PURPOSE: To compare visual acuity, refraction, topography, and complications of deep anterior lamellar keratoplasty (DALK) and penetrating keratoplasty (PKP) performed in patients with keratoconus (KCN). METHODS: In this retrospective interventional non-randomized clinical study, patients with moderate to severe KCN that underwent either PKP or DALK for optical corrections were enrolled. The final outcome analysis was performed after complete suture removal for both groups of patients...
May 22, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28533677/in-pursuit-of-belonging-acculturation-perceived-discrimination-and-ethnic-racial-identity-among-latino-youths
#6
Adrienne Juliet Michele Baldwin-White, Elizabeth Kiehne, Adriana Umaña-Taylor, Flavio F Marsiglia
Guided by Bronfenbrenner's ecological systems framework and informed by the rejection-identification model, this study examined the relationship between acculturation, discrimination, and ethnic-racial identity (ERI) searching and affirmation among a sample of Latino youths (N = 830; mean age = 12.2 years). Results revealed that higher levels of acculturation were associated with lower levels of searching and affirmation. Furthermore, higher perceived discrimination was associated with higher affirmation, but unrelated to searching...
March 2017: Social Work Research
https://www.readbyqxmd.com/read/28533501/post-transplant-diabetes-mellitus-after-kidney-transplant-in-hispanics-and-caucasians-treated-with-tacrolimus-based-immunosuppression
#7
Pedro W Baron, Sergio Infante, Regina Peters, Jerusalem Tilahun, Jill Weissman, Lauren Delgado, Arputharaj Higgins Kore, W Lawrence Beeson, Michael E de Vera
BACKGROUND Development of post-transplant diabetes mellitus after kidney transplant (PTDM) significantly increases kidney graft loss and mortality. Several risk factors for PTDM have been reported, including Hispanic ethnicity and the use of calcineurin inhibitors and corticosteroids. The incidence and impact of PTDM in the Hispanic kidney transplant population is unknown. MATERIAL AND METHODS We retrospectively reviewed the medical records of 155 Hispanic and 124 Caucasian patients, who were not diabetics and underwent kidney transplant between January 2006 and December 2011...
May 23, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28532962/from-snomed-ct-to-uberon-transferability-of-evaluation-methodology-between-similarly-structured-ontologies
#8
Gai Elhanan, Christopher Ochs, Jose L V Mejino, Hao Liu, Christopher J Mungall, Yehoshua Perl
OBJECTIVE: To examine whether disjoint partial-area taxonomy, a semantically-based evaluation methodology that has been successfully tested in SNOMED CT, will perform with similar effectiveness on Uberon, an anatomical ontology that belongs to a structurally similar family of ontologies as SNOMED CT. METHOD: A disjoint partial-area taxonomy was generated for Uberon. One hundred randomly selected test concepts that overlap between partial-areas were matched to a same size control sample of non-overlapping concepts...
May 19, 2017: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/28532918/subarachnoid-haemorrhage-in-germany-between-2010-2013-estimated-incidence-rates-based-on-a-nationwide-hospital-discharge-registry
#9
Jasper H van Lieshout, Igor Fischer, Marcel A Kamp, A R T Donders, Jan F Cornelius, Hans-Jakob Steiger, Hieronymus D Boogaarts, Athanasios K Petridis
BACKGROUND: Nordic countries are the primary source for nationwide data on the incidence of subarachnoid haemorrhage (SAH). Reliable estimates of national incidence rates of SAH in other countries are lacking, yet studies from Nordic countries with exceptional incidence rate are sometimes disregarded because of concerns regarding external validity. Autopsies are rarely performed for sudden deaths, therefore estimates of the SAH incidence commonly reflect the hospital discharge rates. Our aim was to estimate the nationwide incidence of non-traumatic SAH in Germany using a national hospital discharge register...
May 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28532853/long-term-test-retest-reliability-of-event-related-potential-erp-recordings-during-treadmill-walking-using-the-mobile-brain-body-imaging-mobi-approach
#10
Brenda R Malcolm, John J Foxe, John S Butler, Wenzhu B Mowrey, Sophie Molholm, Pierfilippo De Sanctis
Advancements in acquisition technology and signal-processing techniques have spurred numerous recent investigations on the electro-cortical signals generated during whole-body motion. This approach, termed Mobile Brain/Body Imaging (MoBI), has the potential to elucidate the neural correlates of perceptual and cognitive processes during real-life activities, such as locomotion. However, as of yet, no one has assessed the long-term stability of event-related potentials (ERPs) recorded under these conditions. Therefore, the objective of the current study was to evaluate the test-retest reliability of cognitive ERPs recorded while walking...
May 19, 2017: Brain Research
https://www.readbyqxmd.com/read/28532691/bio-synthetic-materials-for-immunomodulation-of-islet-transplants
#11
Greg A Foster, Andrés J García
Clinical islet transplantation is an effective therapy in restoring physiological glycemic control in type 1 diabetics. However, allogeneic islets derived from cadaveric sources elicit immune responses that result in acute and chronic islet destruction. To prevent immune destruction of islets, transplant recipients require lifelong delivery of immunosuppressive drugs, which are associated with debilitating side effects. Biomaterial-based strategies to eliminate the need for immunosuppressive drugs are an emerging therapy for improving islet transplantation...
May 19, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28532102/islet-encapsulated-implantable-composite-hollow-fiber-membrane-based-device-a-bioartificial-pancreas
#12
Rohit S Teotia, Sachin Kadam, Atul Kumar Singh, Surendra Kumar Verma, Ashutosh Bahulekar, Sujata Kanetkar, Jayesh Bellare
Islets from xeno-sources and islet like clusters derived from autologus stem cells have emerged as alternatives to cadaveric pancreas used for treatment of type 1 diabetes. However, the immuno-isolation of these islets from the host immune system suffers from the issue of biocompatibility and hypoxia. To overcome the issues of immunobarrier biocompatibility, we developed a Polysulfone (Psf)/TPGS composite hollow fiber membrane (HFM) using a hollow fiber spinning pilot plant specially developed for this purpose...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532003/recent-development-in-cell-encapsulations-and-their-therapeutic-applications
#13
REVIEW
Jiang-Ze Wang, Zhen-Qi Ding, Feng Zhang, Wen-Bin Ye
Chronic and degenerative diseases are the main causes of death in the aging population worldwide. These diseases are currently maintained using long term administration of conventional drugs which are not curative and reduce the life quality of patients. It is urgent to develop new therapeutic approaches for the treatment of these diseases. Cell therapy that involves the injection of viable cell into patients is a promising therapeutic strategy in chronic and degenerative diseases. However, the survival of injected cells in host tissue is limited due to immunoresponse...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28530643/danger-signals-in-regulating-the-immune-response-to-solid-organ-transplantation
#14
Jamie L Todd, Scott M Palmer
Endogenous danger signals, or damage-associated molecular patterns (DAMPs), are generated in response to cell stress and activate innate immunity to provide a pivotal mechanism by which an organism can respond to damaged self. Accumulating experimental and clinical data have established the importance of DAMPs, which signal through innate pattern recognition receptors (PRRs) or DAMP-specific receptors, in regulating the alloresponse to solid organ transplantation (SOT). Moreover, DAMPs may incite distinct downstream cellular responses that could specifically contribute to the development of allograft fibrosis and chronic graft dysfunction...
May 22, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28530440/children-s-reasoning-about-deception-and-defiance-as-ways-of-resisting-parents-and-teachers-directives
#15
Matthew Gingo
This research presented 8-, 10-, and 12-year-olds (N = 120) with hypothetical situations depicting comparably aged children engaging in defiance and deception to circumvent authorities' directives that they disagreed with. The nature of the situations varied in terms of domain (personal, moral, or prudential) and type of authority figure (parent or teacher). Evaluations and justifications for the legitimacy of the directives, defiance, and deception were examined, as were general evaluations of deception. Across domains, increased age was associated with decreased acceptance of directives, and increased acceptance of defiance and deception...
May 22, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28530272/bio-inspired-ni-2-polyphenol-hydrophilic-network-to-achieve-unconventional-high-flux-nanofiltration-membranes-for-environmental-remediation
#16
Fangjie You, Yanchao Xu, Xiaobin Yang, Yanqiu Zhang, Lu Shao
A novel Ni(2+)-polyphenol network was designed as an excellent bio-coating by a one-step strategy to obtain nanofiltration membranes, possessing unconventional high water flux up to 56.1 L m(-2) h(-1) bar(-1) with rose bengal (RB) rejection above 95%. This study provides a facile approach to prepare highly-efficient nanofiltration membranes for wastewater remediation.
May 22, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28529939/naturally-engineered-maturation-of-cardiomyocytes
#17
REVIEW
Gaetano J Scuderi, Jonathan Butcher
Ischemic heart disease remains one of the most prominent causes of mortalities worldwide with heart transplantation being the gold-standard treatment option. However, due to the major limitations associated with heart transplants, such as an inadequate supply and heart rejection, there remains a significant clinical need for a viable cardiac regenerative therapy to restore native myocardial function. Over the course of the previous several decades, researchers have made prominent advances in the field of cardiac regeneration with the creation of in vitro human pluripotent stem cell-derived cardiomyocyte tissue engineered constructs...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28529826/interpersonal-problems-and-negative-affect-in-borderline-personality-and-depressive-disorders-in-daily-life
#18
Johanna Hepp, Sean P Lane, Ryan W Carpenter, Inga Niedtfeld, Whitney C Brown, Timothy J Trull
Theories of Borderline Personality Disorder (BPD) suggest that interpersonal problems in BPD act as triggers for negative affect and, at the same time, are a possible result of affective dysregulation. Therefore, we assessed the relations between momentary negative affect (hostility, sadness, fear) and interpersonal problems (rejection, disagreement) in a sample of 80 BPD and 51 depressed outpatients at 6 time-points over 28 days. Data were analyzed using multivariate multi-level modeling to separate momentary-, day-, and person-level effects...
May 2017: Clinical Psychological Science
https://www.readbyqxmd.com/read/28529527/skeletal-muscle-cell-induction-from-pluripotent-stem-cells
#19
REVIEW
Yusaku Kodaka, Gemachu Rabu, Atsushi Asakura
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have the potential to differentiate into various types of cells including skeletal muscle cells. The approach of converting ESCs/iPSCs into skeletal muscle cells offers hope for patients afflicted with the skeletal muscle diseases such as the Duchenne muscular dystrophy (DMD). Patient-derived iPSCs are an especially ideal cell source to obtain an unlimited number of myogenic cells that escape immune rejection after engraftment. Currently, there are several approaches to induce differentiation of ESCs and iPSCs to skeletal muscle...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28528847/independent-contributions-of-fmri-familiarity-and-novelty-effects-to-recognition-memory-and-their-stability-across-the-adult-lifespan
#20
Marianne de Chastelaine, Julia T Mattson, Tracy H Wang, Brian E Donley, Michael D Rugg
The impact of age on the neural correlates of familiarity-driven recognition memory has received relatively little attention. Here, the relationships between age, the neural correlates of familiarity, and memory performance were investigated using an associative recognition test in young, middle-aged and older participants. Test items comprised studied, rearranged (items studied on different trials) and new word pairs. fMRI 'familiarity effects' were operationalized as greater activity for studied test pairs incorrectly identified as 'rearranged' than for correctly rejected new pairs...
May 18, 2017: NeuroImage
keyword
keyword
25496
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"