Annemarie Heberlein, Rilana Schuster, Alexandra Kleimann, Adrian Groh, Andreas Kordon, Birgitt Opfermann, Ralf Lichtinghagen, Michael Gröschl, Johannes Kornhuber, Stefan Bleich, Helge Frieling, Thomas Hillemacher
AIMS: Neurotrophins have been linked to the symptomatology of alcohol dependence. We aimed to investigate a possible association between the methylation of the promoters of both neurotrophins, the serum levels of the cytokines and core symptoms of alcohol dependence as withdrawal severity and anxiety. METHODS: In this study we investigated a possible association between alterations in the methylation of the BDNF IV/NGF I gene promoter and the cytokines tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) in 55 male alcohol-dependent patients...
January 26, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism