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https://www.readbyqxmd.com/read/29135112/symptom-triggered-alcohol-vapor-inhalation-for-postoperative-alcohol-withdrawal-syndrome-in-patients-with-gastroesophageal-carcinoma
#1
Fengwei Kong, Miao Zhang, Heng Wang, Dong Liu, Ying Wu, Ning Chai, Wenbin Wu
PURPOSE: The purpose of this study was to investigate the feasibility and efficacy of alcohol vapor inhalation during fasting time for cancer patients with alcohol withdrawal symptoms (AWS) after surgery. METHODS: The data of 51 patients after esophagectomy or gastrectomy for gastroesophageal carcinoma in two hospitals from January 2011 to December 2016 was retrospectively analyzed. These patients were diagnosed with AWS with Clinic Institute Alcohol Withdrawal Syndrome Scale (CIWA-Ar) score ≥ 9 in two hospitals during fasting time from January 2011 to December 2016, and they were accordingly divided into alcohol vapor group (n=25) and diazepam group (n=26)...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28981333/evaluation-of-the-appropriate-use-of-a-ciwa-ar-alcohol-withdrawal-protocol-in-the-general-hospital-setting
#2
Amanda S Eloma, Jason M Tucciarone, Edmund M Hayes, Brian D Bronson
BACKGROUND: The Clinical Institute Withdrawal Assessment-Alcohol, Revised (CIWA-Ar) is an assessment tool used to quantify alcohol withdrawal syndrome (AWS) severity and inform benzodiazepine treatment for alcohol withdrawal. OBJECTIVES: To evaluate the prescribing patterns and appropriate use of the CIWA-Ar protocol in a general hospital setting, as determined by the presence or absence of documented AWS risk factors, patients' ability to communicate, and provider awareness of the CIWA-Ar order...
October 5, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28898879/comparison-of-clomethiazole-and-diazepam-in-the-treatment-of-alcohol-withdrawal-syndrome-in-clinical-practice
#3
Hannah Sychla, Gerhard Gründer, Sarah Edith Lammertz
BACKGROUND: The objective of this retrospective study was to compare the effectivity and tolerability of diazepam and clomethiazole in the treatment of alcohol withdrawal syndrome (AWS) in a large clinical sample. METHODS: The data of 566 patients admitted to an intensive care psychiatric unit in Germany (2010-2014) were evaluated. The course of withdrawal was analyzed on a matched sample (n = 152) consisting of a diazepam group (n = 76) and a clomethiazole group (n = 76)...
2017: European Addiction Research
https://www.readbyqxmd.com/read/28822350/baclofen-for-alcohol-withdrawal
#4
REVIEW
Jia Liu, Lu-Ning Wang
BACKGROUND: Baclofen shows potential for rapidly reducing symptoms of severe alcohol withdrawal syndrome (AWS) in people with alcoholism. Treatment with baclofen is easy to manage and rarely produces euphoria or other pleasant effects, or craving for the drug. This is an updated version of the original Cochrane Review published in 2015, Issue 4. OBJECTIVES: To assess the efficacy and safety of baclofen for people with AWS. SEARCH METHODS: We updated our searches of the following databases to March 2017: the Cochrane Drugs and Alcohol Group Specialised Register, CENTRAL, PubMed, Embase, and CINAHL...
August 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28699845/development-and-implementation-of-an-alcohol-withdrawal-protocol-using-a-5-item-scale-the-brief-alcohol-withdrawal-scale-baws
#5
Darius A Rastegar, Dinah Applewhite, Anika A H Alvanzo, Christopher Welsh, Timothy Niessen, Edward S Chen
BACKGROUND: The standard of care for management of alcohol withdrawal is symptom-triggered treatment using the Clinical Institute Withdrawal Assessment for Alcohol (CIWA-Ar). Many items of this 10-question scale rely on subjective assessments of withdrawal symptoms, making it time-consuming and cumbersome to use. Therefore, there is interest in shorter and more objective methods to assess alcohol withdrawal symptoms. METHODS: A 6-item withdrawal scale developed at another institution was piloted...
July 12, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28430931/joint-effects-of-the-epigenetic-alteration-of-neurotrophins-and-cytokine-signaling-a-possible-exploratory-model-of-affective-symptoms-in-alcohol-dependent-patients
#6
Annemarie Heberlein, Rilana Schuster, Alexandra Kleimann, Adrian Groh, Andreas Kordon, Birgitt Opfermann, Ralf Lichtinghagen, Michael Gröschl, Johannes Kornhuber, Stefan Bleich, Helge Frieling, Thomas Hillemacher
Aims: Neurotrophins have been linked to the symptomatology of alcohol dependence. We aimed to investigate a possible association between the methylation of the promoters of both neurotrophins, the serum levels of the cytokines and core symptoms of alcohol dependence as withdrawal severity and anxiety. Methods: In this study we investigated a possible association between alterations in the methylation of the BDNF IV/NGF I gene promoter and the cytokines tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) in 55 male alcohol-dependent patients...
May 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28266937/occurrence-predictors-and-prognosis-of-alcohol-withdrawal-syndrome-and-delirium-tremens-following-traumatic-injury
#7
MULTICENTER STUDY
Kristin Salottolo, Emmett McGuire, Charles W Mains, Erika C van Doorn, David Bar-Or
OBJECTIVES: We sought to determine occurrence, predictors, and prognosis of alcohol withdrawal syndrome and delirium tremens in patients with traumatic injury. DESIGN: Retrospective multicenter cohort study. SETTING: Three U.S. trauma centers. PATIENTS: Twenty-eight thousand one hundred one trauma patients admitted from 2010-2014. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Measures included occurrence of alcohol withdrawal syndrome and delirium tremens, injury characteristics, risk factors for alcohol withdrawal syndrome, clinical outcomes, pharmacologic treatment for alcohol withdrawal syndrome, and Clinical Institute Withdrawal Assessment for Alcohol, Revised (CIWA-Ar) scores...
May 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28139538/sexual-dysfunctions-in-alcohol-dependent-men-a-study-from-north-india
#8
Shreyas Pendharkar, Surendra K Mattoo, Sandeep Grover
BACKGROUND & OBJECTIVES: Sexual dysfunctions have been reported in alcohol-dependent men. Most of the studies conducted had limitation of using non-validated measures of sexual dysfunction and sampling design. This study was, therefore, conducted to determine the typology, demographic and clinical correlates of sexual dysfunction in alcohol-dependent men. METHODS: One hundred and one patients with alcohol dependence (AD) attending the Drug De-addiction and Treatment Centre and 50 healthy controls were evaluated in this cross-sectional study...
September 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28126716/joint-effects-of-the-epigenetic-alteration-of-neurotrophins-and-cytokine-signaling-a-possible-exploratory-model-of-affective-symptoms-in-alcohol-dependent-patients
#9
Annemarie Heberlein, Rilana Schuster, Alexandra Kleimann, Adrian Groh, Andreas Kordon, Birgitt Opfermann, Ralf Lichtinghagen, Michael Gröschl, Johannes Kornhuber, Stefan Bleich, Helge Frieling, Thomas Hillemacher
AIMS: Neurotrophins have been linked to the symptomatology of alcohol dependence. We aimed to investigate a possible association between the methylation of the promoters of both neurotrophins, the serum levels of the cytokines and core symptoms of alcohol dependence as withdrawal severity and anxiety. METHODS: In this study we investigated a possible association between alterations in the methylation of the BDNF IV/NGF I gene promoter and the cytokines tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) in 55 male alcohol-dependent patients...
January 26, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/27850515/877-correlation-between-mminds-and-ciwa-ar-scoring-tools-in-patients-with-alcohol-withdrawal-syndrome
#10
Audrey Littlefield, Claire Chan, Dawn Cooper, Jason Heavner, Jeanette Kurtz, Margaret Pisani, Mojdeh Heavner
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27827830/do-alcohol-misuse-service-utilisation-and-demographic-characteristics-differ-between-uk-veterans-and-members-of-the-general-public-attending-an-nhs-general-hospital
#11
Dominic Murphy, Emily Palmer, Greta Westwood, Walter Busuttil, Neil Greenberg
The aim of this paper was to provide insights into alcohol misuse within UK veterans to inform as to whether their presentations differ from the general public. This was done by exploring differences in the severity of alcohol misuse between UK veterans and the general public admitted to a general NHS hospital over an 18 month period using retrospective data. All patients admitted to the hospital were screened for alcohol misuse. Those deemed as experiencing problems were referred for specialist nurse-led support...
November 2, 2016: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/27803505/outcomes-after-implementation-of-an-alcohol-withdrawal-protocol-at-a-single-institution
#12
Mary E Eberly, Anna G Lockwood, Sean Lockwood, Kelly W Davis
Background: There are varying dosing strategies for the administration of benzodiazepines in the setting of alcohol withdrawal. In October 2014, a symptom-based alcohol withdrawal protocol (AWP) using the Clinical Institute Withdrawal Assessment of Alcohol, Revised (CIWA-Ar) scale was implemented at one institution. Objective: To evaluate the safety and efficacy of the AWP. Methods: Retrospective chart review was completed, including patients receiving at least one dose of diazepam for alcohol withdrawal pre- and post-protocol...
October 2016: Hospital Pharmacy
https://www.readbyqxmd.com/read/27733668/a-symptom-triggered-benzodiazepine-protocol-utilizing-sas-and-ciwa-ar-scoring-for-the-treatment-of-alcohol-withdrawal-syndrome-in-the-critically-ill
#13
Soumitra Sen, Philip Grgurich, Amanda Tulolo, Andrew Smith-Freedman, Yuxiu Lei, Anthony Gray, James Dargin
BACKGROUND: There are limited data on the efficacy of symptom-triggered therapy for alcohol withdrawal syndrome (AWS) in the intensive care unit (ICU). OBJECTIVE: To evaluate the safety and efficacy of a symptom-triggered benzodiazepine protocol utilizing Riker Sedation Agitation Scale (SAS) scoring for the treatment of AWS in the ICU. METHODS: We performed a before-and-after study in a medical ICU. A protocol incorporating SAS scoring and symptom-triggered benzodiazepine dosing was implemented in place of a protocol that utilized the Clinical Institute Withdrawal Assessment for Alcohol (CIWA-Ar) scale and fixed benzodiazepine dosing...
February 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27262870/comparison-of-enteral-ethanol-and-benzodiazepines-for-alcohol-withdrawal-in-neurocritical-care-patients
#14
COMPARATIVE STUDY
Gregory Gipson, Kim Tran, Cuong Hoang, Miriam Treggiari
We designed a study to evaluate the use of benzodiazepines and ethanol in patients being assessed for alcohol withdrawal and compare outcomes between the two agents. This is a retrospective chart review of patients admitted to neurocritical care or neurosurgical services who were at risk for ethanol withdrawal between June 2011 and September 2015. Patients were divided into two groups based on the first medication administered for alcohol withdrawal management, either benzodiazepine (n=50) or enteral ethanol (n=50)...
September 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27159343/ast-a-simplified-3-item-tool-for-managing-alcohol-withdrawal
#15
Samuel B Holzman, Darius A Rastegar
AIMS: This study compared the Glasgow Modified Alcohol Withdrawal Scale (GMAWS) and a newly devised 3-item "Anxiety Sweats Tremor" Scale (AST) to the Revised Clinical Institute Withdrawal Assessment Scale (CIWA-Ar)-the standard of care for symptom-triggered management of alcohol withdrawal syndrome. METHODS: Our study took place over 2 separate 1-week observational periods, and included 332 serial evaluations from 85 unique patients. All study participants were treated per hospital protocol based on CIWA-Ar, with supplemental scoring initially by GMAWS and later by AST in tandem...
May 2016: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/27105601/a-randomized-open-label-standard-controlled-parallel-group-study-of-efficacy-and-safety-of-baclofen-and-chlordiazepoxide-in-uncomplicated-alcohol-withdrawal-syndrome
#16
RANDOMIZED CONTROLLED TRIAL
K Girish, K Vikram Reddy, Lakshmi V Pandit, H P Pundarikaksha, R Vijendra, K Vasundara, R Manjunatha, Moulya Nagraj, R Shruthi
BACKGROUND: Alcohol withdrawal syndrome (AWS) is a distressing condition, generally controlled by benzodiazepines (BZD's). Baclofen, a gamma-aminobutyric acid-B (GABAB) agonist, has also shown promising results in controlling AWS. As there are few studies comparing the efficacy and tolerability of chlordiazepoxide with baclofen, the present study was taken up. The objective of this study was to compare efficacy and tolerability of baclofen with chlordiazepoxide in uncomplicated AWS. METHODS: Sixty subjects with uncomplicated AWS were randomized into two groups of 30 each, to receive baclofen (30 mg) or chlordiazepoxide (75 mg) in decremented fixed dose regime for 9 days...
February 2016: Biomedical Journal
https://www.readbyqxmd.com/read/27099220/role-of-cyp2c19-gene-polymorphism-in-acute-alcohol-withdrawal-treatment-with-loading-dose-of-diazepam-in-a-south-indian-population
#17
Manu Jose, Jayanthi Mathaiyan, Shivanand Kattimani, Surendiran Adithan, Adithan Chandrasekaran
PURPOSE: Alcohol dependence is a public health problem worldwide, commonly associated with withdrawal symptoms for which diazepam is a frequently used drug. We studied the effect of CYP2C19 gene polymorphisms on diazepam loading dose requirement and time to reversal of acute alcohol withdrawal symptoms. We also studied the influence of the polymorphism in this gene on the persistent symptoms after loading dose of diazepam. METHODS: Sixty-nine patients who reported to the psychiatry department with symptoms of alcohol withdrawal diagnosed by DSM-IV criteria were included for the study...
July 2016: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/26962719/pilot-trial-of-gabapentin-for-the-treatment-of-benzodiazepine-abuse-or-dependence-in-methadone-maintenance-patients
#18
RANDOMIZED CONTROLLED TRIAL
John J Mariani, Robert J Malcolm, Agnieszka K Mamczur, Jean C Choi, Ronald Brady, Edward Nunes, Frances R Levin
BACKGROUND: Benzodiazepine use disorders are a common clinical problem among methadone maintenance treatment patients and have adverse effects on clinical outcomes. OBJECTIVES: To evaluate gabapentin for the outpatient treatment of benzodiazepine abuse or dependence in methadone maintenance patients. METHODS: Participants (n = 19) using benzodiazepines at least 4 days per week were enrolled into an 8-week randomized double-blind placebo-controlled outpatient pilot trial...
May 2016: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/26929223/something-old-something-new-a-successful-case-of-meprobamate-withdrawal
#19
Alexander Owen James, Timothy R Nicholson, Robert Hill, Jennifer Bearn
Meprobamate, a benzodiazepine-like drug, was commonly prescribed for anxiety in the 1960s and 1970s, but fell out of favour, at least in part, due to the risk of dependence, for which there is little published evidence to guide clinical management. We discuss a 70-year-old man with a 45-year history of meprobamate dependency and multiple failed previous withdrawal attempts who was successfully withdrawn from meprobamate using diazepam during a 2-week inpatient stay on a specialist Addictions ward. An appropriate diazepam dose was established using the Clinical Institute Withdrawal Assessment scale for benzodiazepines (CIWA-B)...
February 29, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/26876819/genetic-variation-in-the-vesicular-monoamine-transporter-1-vmat1-slc18a1-gene-and-alcohol-withdrawal-severity
#20
Nisha Dutta, Sarah G Helton, Melanie Schwandt, Xi Zhu, Reza Momenan, Falk W Lohoff
BACKGROUND: Alcohol withdrawal (AW) can be a serious consequence of alcohol dependence and consists of various neurochemical adaptations in the brain. One such neuroadaptation occurs in the monoamine neurotransmitter system. Recently, a functional variant in the presynaptic vesicular monoamine transporter gene (VMAT1/SLC18A1-Thr136Ile-rs1390938) was found to significantly increase transport of monoamines into synaptic vesicles in vitro. We hypothesize that the alteration of magnitude of monoamine release contributes to severity of AW symptoms...
March 2016: Alcoholism, Clinical and Experimental Research
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