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https://www.readbyqxmd.com/read/28092450/preintervention-profiles-of-information-motivational-and-behavioral-self-efficacy-for-methamphetamine-use-and-hiv-medication-adherence-among-gay-and-bisexual-men
#1
Tyrel J Starks, Brett M Millar, Jonathan M Lassiter, Jeffrey T Parsons
Although rates of crystal methamphetamine use in the United States have fallen from their peak in the mid-2000s, use remains a major public health concern, which disproportionately affects gay and bisexual men (GBM). It poses a particular challenge for HIV-positive men, for whom it has been linked to medication adherence problems as well as compromised immune function. Although the information, motivation, and behavioral skills (IMB) model has been widely used to conceptualize health behavior, little is known about GBM's initial levels of information, motivation, and behavioral self-efficacy to improve HIV medication adherence and to reduce crystal methamphetamine use at the outset of treatment...
January 16, 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28092168/associations-between-at-risk-alcohol-use-substance-use-and-smoking-with-lipohypertrophy-and-lipoatrophy-among-patients-living-with-hiv
#2
Marisela Noorhasan, Daniel Drozd, Carl Grunfeld, Joe Merrill, Greer Burkholder, Michael J Mugavero, James H Willig, Amanda Willig, Karen L Cropsey, Kenneth Mayer, Aaron Blashill, Matthew Mimiaga, Mary E McCaul, Heidi Hutton, Geetanjali Chander, William C Matthews, Sonia Napravnik, Joseph J Eron, Katerina Christopoulos, Rob Fredericksen, Robin Nance, Joseph Chris Delaney, Paul Crane, Michael Saag, Mari M Kitahata, Heidi Crane
OBJECTIVE: To examine associations between lipohypertrophy and lipoatrophy and illicit drug use, smoking, and at-risk alcohol use among a large diverse cohort of persons living with HIV (PLWH) in clinical care. METHODS: 7,931 PLWH at 6 sites across the US completed 21,279 clinical assessments including lipohypertrophy and lipoatrophy, drug/alcohol use, physical activity level, and smoking. Lipohypertrophy and lipoatrophy were measured using the FRAM body morphology instrument and associations were assessed with generalized estimating equations...
January 16, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28089854/effects-of-adolescent-methamphetamine-and-nicotine-exposure-on-behavioral-performance-and-map-2-immunoreactivity-in-the-nucleus-accumbens-of-adolescent-mice
#3
Jordan M Buck, Alysse S Morris, Sydney J Weber, Jacob Raber, Jessica A Siegel
The neurotoxic effects of methamphetamine (MA) exposure in the developing and adult brain can lead to behavioral alterations and cognitive deficits in adults. Previous increases in the rates of adolescent MA use necessitate that we understand the behavioral and cognitive effects of MA exposure during adolescence on the adolescent brain. Adolescents using MA exhibit high rates of nicotine (NIC) use, but the effects of concurrent MA and NIC in the adolescent brain have not been examined, and it is unknown if NIC mediates any of the effects of MA in the adolescent...
January 12, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28081482/following-lives-undergoing-change-flux-study-implementation-and-baseline-prevalence-of-drug-use-in-an-online-cohort-study-of-gay-and-bisexual-men-in-australia
#4
Mohamed A Hammoud, Fengyi Jin, Louisa Degenhardt, Toby Lea, Lisa Maher, Jeffrey Grierson, Brent Mackie, Marcus Pastorelli, Colin Batrouney, Nicky Bath, Jack Bradley, Garrett P Prestage
BACKGROUND: Drug use among gay and bisexual men (GBM) is higher than most populations. The use of crystal methamphetamine, erectile dysfunction medication (EDM), and amyl nitrite have been associated with sexual risk behaviour and HIV infection among gay and bisexual men (GBM). OBJECTIVE: This paper describes an online prospective observational study of licit and illicit drug use among GBM and explores baseline prevalence of drug use in this sample. Capturing these data poses challenges as participants are required to disclose potentially illegal behaviours in a geographically dispersed country...
January 9, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28081472/endoplasmic-reticulum-stress-and-apoptosis-via-perk-eif2%C3%AE-chop-signaling-in-the-methamphetamine-induced-chronic-pulmonary-injury
#5
Yu-Han Gu, Yun Wang, Yang Bai, Ming Liu, Huai-Liang Wang
Methamphetamine (MA) leads to multiple organs lesions and apoptosis. The aim of this study is to investigate if endoplasmic reticulum stress (ERS) - initiated apoptosis is involved in the chronic pulmonary injury induced by MA. In this study, rats were divided into a control group, methamphetamine 5mg/kg group and methamphetamine 10mg/kg group. This study found that the protein level of GRP78 is higher in M10 group than in control group. PERK signaling and the relevant apoptosis factors were also activated...
January 3, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28079530/can-intoxication-status-be-used-as-a-prediction-tool-for-manner-of-death-a-comparison-of-the-intoxication-status-in-violent-suicides-and-homicides
#6
D Kimberley Molina, Veronica M Hargrove
Determining the manner of death in medicolegal death investigations can be difficult. The investigator relies on many facets of death investigation, including the circumstances of death and autopsy examination. A study was designed to analyze whether the intoxication status of the decedent could be used as another tool in death investigations. The intoxication status of violent (nonoverdose or poisoning) suicides and homicides was retrospectively reviewed and compared. A total of 625 deaths were identified, including 366 suicides and 259 homicides...
January 10, 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28076917/multi-organ-dysfunction-due-to-bath-salts-are-we-aware-of-this-entity
#7
Rohith Valsalan, Benoj Varghese, Diya Soman, Jonathan Buckmaster, Steven Yew, David Cooper
Methylenedioxypyrovalerone (MDPV) is a synthetic, cathinone-derivative, central nervous system stimulant taken to produce a cocaine- or methamphetamine-like high. Physical manifestations include tachycardia, hypertension, arrhythmias, hyperthermia, sweating, rhabdomyolysis, hyperkalaemia, disseminated intravascular coagulation, oliguria and seizures. We report a patient who presented with severe metabolic acidosis, multi-organ dysfunction, rhabdomyolysis, hyperkalaemia and seizures. This case highlights that even though a urine drug screen for routine psychostimulant drugs is negative, clinicians need to be vigilant about the adverse effects of MDPV as a possible cause of multi-organ dysfunction...
January 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28074940/alpha7-nicotinic-acetylcholine-receptor-is-required-for-amyloid-pathology-in-brain-endothelial-cells-induced-by-glycoprotein-120-methamphetamine-and-nicotine
#8
Liqun Liu, Jingyi Yu, Li Li, Bao Zhang, Lingjuan Liu, Chun-Hua Wu, Ambrose Jong, Ding-An Mao, Sheng-He Huang
One of the most challenging issues in HIV-associated neurocognitive disorders (HAND) caused by HIV-1 virotoxins and drug abuse is the lack of understanding the underlying mechanisms that are commonly associated with disorders of the blood-brain barrier (BBB), which mainly consists of brain microvascular endothelial cells (BMEC). Here, we hypothesized that Glycoprotein 120 (gp120), methamphetamine (METH) and nicotine (NT) can enhance amyloid-beta (Aβ) accumulation in BMEC through Alpha7 nicotinic acetylcholine receptor (α7 nAChR)...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28073060/acute-behavioral-effects-of-co-administration-of-mephedrone-and-mdma-in-mice
#9
Barbara Budzynska, Agnieszka Michalak, Małgorzata Frankowska, Katarzyna Kaszubska, Grażyna Biała
BACKGROUND: Abuse of more than one psychoactive drug is becoming a global problem. Our experiments were designed to examine the effects of a concomitant administration of 3,4-methylenedioxy-methamphetamine (MDMA) and mephedrone on depression- and anxiety-like behaviors and cognitive processes in Swiss mice. METHODS: In order to investigate the drug interactions the forced swimming test (FST) - an animal model of depression, the passive avoidance (PA) test - a memory and learning paradigm, as well as the elevated plus maze (EPM) test - test for anxiety level were used...
October 11, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28070621/behavioral-evidence-for-the-abuse-potential-of-the-novel-synthetic-cathinone-alpha-pyrrolidinopentiothiophenone-pvt-in-rodents
#10
Jae Hoon Cheong, Mee Jung Choi, Choon-Gon Jang, Yong Sup Lee, Sooyeun Lee, Hee Jin Kim, Joung-Wook Seo, Seong Shoon Yoon
RATIONALE: Synthetic cathinones are chemical derivatives of cathinone that are pharmacologically similar to cocaine and methamphetamine. Recently, abuse of synthetic cathinones among young people has increased. OBJECTIVES: The present study aimed to characterize the behavioral effects of alpha-pyrrolidinopentiothiophenone (PVT), an analog of alpha-pyrrolidinovalerophenone and second-generation synthetic cathinone, as well as to evaluate its abuse potential, using conditioned place preference, intravenous self-administration (SA), and drug discrimination paradigms in rodent models...
January 9, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28070110/melatonin-suppresses-methamphetamine-triggered-endoplasmic-reticulum-stress-in-c6-cells-glioma-cell-lines
#11
Wanida Tungkum, Pichaya Jumnongprakhon, Chainarong Tocharus, Piyarat Govitrapong, Jiraporn Tocharus
Methamphetamine (METH) is a neurotoxic drug that causes brain damage by inducing neuronal and glial cell death together with glial cell hyperactivity-mediated progressive neurodegeneration. Previous studies have shown that METH induced glial cell hyperactivity and death via oxidative stress, the inflammatory response, and endoplasmic reticulum stress (ER stress) mechanisms, and melatonin could reverse these effects. However, the exact mechanism of the protective role of melatonin in METH-mediated ER stress has not been understood...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28068828/key-differences-in-treatment-seeking-stimulant-users-attending-a-specialised-treatment-service-a-means-of-early-intervention
#12
Shalini Arunogiri, Margret Petrie, Michelle Sharkey, Dan I Lubman
OBJECTIVES: Few people who use stimulants seek clinical treatment. This study sought to describe a cohort of stimulant users who attended a stimulant-specific treatment service, Access Point, in Melbourne, Australia between 2008 and 2014. METHODS: A retrospective audit of the records of adults ( n = 175) who sought treatment for stimulant use at a stimulant-specific outpatient treatment service was conducted. RESULTS: Service users had a median age of 32 (range = 19-54)...
January 1, 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28063946/the-abuse-potential-of-two-novel-synthetic-cathinones-with-modification-on-the-alpha-carbon-position-2-cyclohexyl-2-methylamino-1-phenylethanone-machp-and-2-methylamino-1-phenyloctan-1-one-maop-and-their-effects-on-dopaminergic-activity
#13
Chrislean Jun Botanas, Seong Shoon Yoon, June Bryan de la Peña, Irene Joy Dela Peña, Mikyung Kim, Taeseon Woo, Joung-Wook Seo, Choon-Gon Jang, Kyung-Tae Park, Young Hun Lee, Yong Sup Lee, Hee Jin Kim, Jae Hoon Cheong
The recreational use of synthetic cathinones has dramatically increased in recent years, which is partly due to easy accessibility and ability of synthetic cathinones to exert rewarding effects similar to cocaine and methamphetamine. Many synthetic cathinones have already been scheduled in several countries; however, novel and diverse synthetic cathinones are emerging at an unprecedented rate, often outpacing regulatory processes. Recently, designer modifications of the basic cathinone molecule are usually performed on the alpha-carbon position...
January 4, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28063836/inhibiting-effects-of-rhynchophylline-on-methamphetamine-dependent-zebrafish-are-related-with-the-expression-of-tyrosine-hydroxylase-th
#14
Chen Zhu, Wei Liu, Chaohua Luo, Yi Liu, Chan Li, Miao Fang, Yingbo Lin, Jinying Ou, Minting Chen, Daoqi Zhu, Ken Kin-Lam Yung, Zhixian Mo
In this study, to study the effect of rhynchophylline on TH in midbrain of methamphetamine-induced conditioned place preference (CPP) adult zebrafish, place preference adult zebrafish models were established by methamphetamine (40μg/g) and the expression of TH was observed by immunohistochemistry technique and Western blot. Ketamine (150μg/g), high dose of rhynchophylline (100μg/g) group can significantly reduce the place preference; immunohistochemistry results showed that the number of TH-positive neurons in midbrain was increased in the methamphetamine model group, whereas less TH-positive neurons were found in the ketamine group and high dosage rhynchophylline group...
January 5, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28057490/blockade-of-patch-based-%C3%AE-opioid-receptors-in-the-striatum-attenuates-methamphetamine-induced-conditioned-place-preference-and-reduces-activation-of-the-patch-compartment
#15
Kristen A Horner, Mary Caroline Logan, Trevor J Fisher, Jordan B Logue
The behavioral effects of methamphetamine (METH) are mediated by the striatum, which is divided into the patch compartment, which mediates limbic and reward functions, and the matrix compartment, which mediates sensorimotor tasks. METH treatment results in repetitive behavior that is related to enhanced relative activation of the patch versus the matrix compartment. The patch, but not the matrix compartment contains a high density of μ opioid receptors, and localized blockade of patch-based μ opioid receptors attenuates METH-induced patch-enhanced activity and repetitive behaviors...
January 3, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28057187/challenges-in-laboratory-detection-of-unusual-substance-abuse-issues-with-magic-mushroom-peyote-cactus-khat-and-solvent-abuse
#16
A Dasgupta
Drug abuse is a worldwide problem. Although commonly abused drugs can be identified during routine urine drug testing, less commonly abused drugs may escape detection. These less commonly abused drugs not only include some designer drugs such as synthetic cannabinoid but also include abuse of psychedelic magic mushroom (active ingredients: psilocybin and psilocin), peyote cactus (active ingredient: mescaline), and khat plants (active ingredient: cathinone). Moreover, solvent and glue abuse is gaining popularity among teenagers and young adults which may even cause fatality...
2017: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/28056000/adverse-health-effects-associated-with-living-in-a-former-methamphetamine-drug-laboratory-victoria-australia-2015
#17
Jackie Wright, Michaela E Kenneally, John W Edwards, G Stewart Walker
The manufacture of methamphetamine in clandestine drug laboratories occurs in various locations, including residential houses and apartments. Unlike the controlled manufacture of chemicals and drugs, clandestine manufacture results in the uncontrolled storage, use, generation, and disposal of a wide range of chemicals and the deposit of methamphetamine drug residues on indoor surfaces (1). These residues have been found at high levels on porous and nonporous surfaces and have been shown to persist for months to years (1)...
January 6, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28051103/maladaptive-sex-behavior-following-concurrent-methamphetamine-and-sexual-experience-in-male-rats-is-associated-with-altered-neural-activity-in-frontal-cortex
#18
Lindsey B Kuiper, Karla S Frohmader, Lique M Coolen
The use of psychostimulants is often associated with hypersexuality, and psychostimulant users have identified the effects of drug on sexual behavior as a reason for further use. It was previously demonstrated that methamphetamine (Meth), when administered concurrently with sexual behavior show impairment of inhibition of sexual behavior in a conditioned sex aversion (CSA) paradigm where mating is paired with illness. This is indicative of maladaptive sex behavior following Meth and sex experience. The present study examined the neural pathways activated during inhibition of sexual behavior and the effects of concurrent Meth and sexual behavior on neural activity in these pathways, using ERK phosphorylation (pERK) as neural activity marker...
January 4, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28045725/utilization-of-stand-by-extracorporeal-membrane-oxygenation-in-a-high-risk-parturient-with-methamphetamine-associated-cardiomyopathy-undergoing-dilation-and-evacuation-a-case-report
#19
Cesar Padilla, Antonio Hernandez Conte, Danny Ramzy, Lorraine Lubin, Troy LaBounty, Judith H Chung, Ying Zeng
Parturients may present with evidence of acute heart failure or respiratory distress during the peripartum period. This case report documents utilization of "stand-by" extracorporeal membrane oxygenation (ECMO) for a 40-year-old woman with a history of severe left ventricular dysfunction who presented for elective dilation and evacuation of triplets at 20 weeks' gestation. The patient's medical history was significant for hypertension, diabetes mellitus, methamphetamine use (acute/chronic), and cardiac-respiratory arrest before her previous emergent cesarean delivery...
December 30, 2016: A & A Case Reports
https://www.readbyqxmd.com/read/28045134/methamphetamine-and-ovarian-steroid-responsive-cells-in-the-posteriodorsal-medial-amygdala-are-required-for-methamphetamine-enhanced-proceptive-behaviors
#20
Katrina M Williams, Jessica A Mong
Methamphetamine (Meth) is a psychomotor stimulant strongly associated with increases in sexual drive and impulse in both men and women. These changes in sexual motivation have a greater impact on women due to their likelihood of facing the greater burden of unplanned pregnancies, as well as increased risk for psychiatric co-morbidities such as depression. We have previously established a rodent model of Meth-induced increases in sexual motivation. Using this model, we have identified the posteriodorsal medial amygdala (MePD) via excitotoxic lesion studies as a necessary nucleus in Meth-facilitated female sexual motivation...
January 3, 2017: Scientific Reports
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