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https://www.readbyqxmd.com/read/27909988/predicting-the-abuse-liability-of-entactogen-class-new-and-emerging-psychoactive-substances-via-preclinical-models-of-drug-self-administration
#1
Shawn M Aarde, Michael A Taffe
Animal models of drug self-administration are currently the gold standard for making predictions regarding the relative likelihood that a recreational drug substance will lead to continued use and addiction. Such models have been found to have high predictive accuracy and discriminative validity for a number of drug classes including ethanol, nicotine, opioids, and psychostimulants such as cocaine and methamphetamine. Members of the entactogen class of psychostimulants (drugs that produce an "open mind state" including feelings of interpersonal closeness, intimacy and empathy) have been less frequently studied in self-administration models...
December 2, 2016: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27907276/clinical-course-of-methamphetamine-induced-psychotic-disorder-in-a-3-month-follow-up
#2
Sakineh Javadian, Amir Shabani, Seyed Vahid Shariat
Objective: To assess the clinical course of patients with methamphetamine-induced psychotic disorder (MIPD) and any possible predictors of the clinical course in a 3-month follow-up. Methods: This prospective cohort study included 50 patients (7 female, 43 male) with MIPD and was performed from September 2014 to October 2015. Patients were assessed during hospitalization and in a follow-up visit 3 months later. Diagnoses were made using interviews based on the Structured Clinical Interview for DSM-IV Axis I Disorders...
November 3, 2016: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/27906980/patterns-of-sexual-behavior-in-lowland-thai-youth-and-ethnic-minorities-attending-high-school-in-rural-chiang-mai-thailand
#3
Linda Aurpibul, Arunrat Tangmunkongvorakul, Patou Masika Musumari, Kriengkrai Srithanaviboonchai, Surapee Tarnkehard
INTRODUCTION: The rural areas of Northern Thailand are home to a large cultural diversity of ethnic minority groups. Previous studies have shown that young people in rural Thailand have low levels of knowledge on HIV/AIDS and high sexual risks. We compared sexual behaviors between the lowland Thai youth and the youth from ethnic minority groups. METHODS AND FINDINGS: This is a cross-sectional quantitative study conducted among high-school Thai and ethnic students in Chiang Mai...
2016: PloS One
https://www.readbyqxmd.com/read/27905916/study-protocol-a-dose-escalating-phase-2-study-of-oral-lisdexamfetamine-in-adults-with-methamphetamine-dependence
#4
Nadine Ezard, Adrian Dunlop, Brendan Clifford, Raimondo Bruno, Andrew Carr, Alexandra Bissaker, Nicholas Lintzeris
BACKGROUND: The treatment of methamphetamine dependence is a continuing global health problem. Agonist type pharmacotherapies have been used successfully to treat opioid and nicotine dependence and are being studied for the treatment of methamphetamine dependence. One potential candidate is lisdexamfetamine, a pro-drug for dexamphetamine, which has a longer lasting therapeutic action with a lowered abuse potential. The purpose of this study is to determine the safety of lisdexamfetamine in this population at doses higher than those currently approved for attention deficit hyperactivity disorder or binge eating disorder...
December 1, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27905179/methamphetamine-related-psychosis-an-opportunity-for-assertive-intervention-and-prevention
#5
EDITORIAL
Julia M Lappin, Grant E Sara, Michael Farrell
No abstract text is available yet for this article.
December 1, 2016: Addiction
https://www.readbyqxmd.com/read/27905014/sexual-venue-choice-and-sexual-risk-taking-among-substance-using-men-who-have-sex-with-men
#6
Joshua A Rusow, Jesse B Fletcher, Cathy J Reback
Commercial sex venues (CSVs) and public sex environments (PSEs) offer men who have sex with men (MSM) sexual privacy and anonymity. Sociodemographic characteristics (e.g., race/ethnicity, sexual identity, age, HIV status) are correlated with individuals' choice of sexual venue, potentially suggesting environmental associations with both sociodemographics and sexual risk. From March 2005 through March 2012, 1298 substance-using MSM provided information on their most recent sexual encounter; iterative logit models estimated associations between sociodemographics and sexual venue, and/or whether sexual venue was associated with sexual risk-taking while controlling for sociodemographics...
November 30, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27903083/club-drugs-and-alcohol-abuse-predicted-dropout-and-poor-adherence-among-methadone-maintenance-treatment-patients-in-guangzhou-china
#7
Di Liu, Jing Gu, Huifang Xu, Chun Hao, Mingxu Jiao, Xiao Zhang, Yuteng Zhao, Babbitt Andrew, Yuantao Hao
Club drugs and alcohol abuse are prevalent among methadone maintenance treatment (MMT) patients. However, little is known about the association between these abuse and treatment outcomes among MMT patients. The aim of this study was to examine the prevalence of club drugs and alcohol abuse among MMT patients and to investigate the associations between these abuse and treatment outcomes - dropout and poor adherence. In this one-year cohort study conducting in Guangzhou, China, data including background characteristics, club drugs use in the last six months, alcohol use history and treatment-related information was collected...
November 30, 2016: AIDS Care
https://www.readbyqxmd.com/read/27902717/could-google-trends-be-used-to-predict-methamphetamine-related-crime-an-analysis-of-search-volume-data-in-switzerland-germany-and-austria
#8
Alex Gamma, Roman Schleifer, Wolfgang Weinmann, Anna Buadze, Michael Liebrenz
OBJECTIVE: To compare the time trends of Google search interest in methamphetamine and criminal offences related to this drug. METHODS: Google Trends data for the search term "meth" was compared to methamphetamine-related crime statistics (incl. use, possession, and dealing) in Switzerland, Germany, and Austria for the years 2004-2016. Google data was availably monthly. Crime data was available yearly, and monthly values were imputed. RESULTS: On the country level, internet search trends for "meth" roughly paralleled relevant criminal activity...
2016: PloS One
https://www.readbyqxmd.com/read/27900649/brief-report-a-randomized-control-trial-assessing-the-influence-of-a-telephone-based-intervention-on-readmissions-for-patients-with-severe-mental-illness-in-a-developing-country
#9
U A Botha, L Koen, M Mazinu, E Jordaan, D J H Niehaus
Whilst comprehensive post-discharge interventions have been successful in reducing readmissions in our setting, they are possibly not sustainable due to limited resources. We assessed the impact of a more cost-effective telephone-based intervention on readmissions in a developing country over 12 months. 100 patients with severe mental illness were randomized to facilitated care or treatment as usual. All were interviewed prior to discharge and after 12 months. Facilitated care consisted of structured telephonic interviews and motivational support to patients and families...
November 30, 2016: Community Mental Health Journal
https://www.readbyqxmd.com/read/27896377/self-administration-and-behavioral-economics-of-second-generation-synthetic-cathinones-in-male-rats
#10
S L Huskinson, J E Naylor, E A Townsend, J K Rowlett, B E Blough, K B Freeman
RATIONALE: Synthetic cathinones have become increasingly available as drugs of abuse. Distribution of these drugs is made possible by altering the chemical structures of prohibited cathinones and marketing them under misleading labels. Very little is known about the relative reinforcing effectiveness of new synthetic cathinones relative to known drugs of abuse. OBJECTIVE: We examined self-administration of three second-generation synthetic cathinones: alpha-pyrrolidinopentiophenone (alpha-PVP), 4-methyl-N-ethylcathinone (4-MEC), and 4-methyl-alpha-pyrrolidinopropiophenone (4-MePPP) relative to methamphetamine...
November 28, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27894467/association-between-hair-cortisol-concentration-and-perceived-stress-in-female-methamphetamine-addicts
#11
Liuna Geng, Peng Xiang, Jin Yang, Hui Shen, Zhiqin Sang
OBJECTIVE: The present study aims to explore whether hair cortisol concentration is associated with explicit stress or implicit stress in female methamphetamine addicts. METHODS: Hair samples were collected from 51 female methamphetamine addicts from inpatient addiction treatment programs. Perceived stress was assessed by both explicit and implicit measures through the Perceived Stress Scale (PSS) and the Implicit Association Test (IAT), respectively. RESULTS: The positive relationship between hair cortisol concentration with D-scores of the IAT reached statistically significant difference...
December 2016: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/27890469/methamphetamine-addiction-vulnerability-the-glutamate-the-bad-and-the-ugly
#12
Karen K Szumlinski, Kevin D Lominac, Rianne R Campbell, Matan Cohen, Elissa K Fultz, Chelsea N Brown, Bailey W Miller, Sema G Quadir, Douglas Martin, Andrew B Thompson, Georg von Jonquieres, Matthias Klugmann, Tamara J Phillips, Tod E Kippin
BACKGROUND: The high prevalence and severity of methamphetamine (MA) abuse demands greater neurobiological understanding of its etiology. METHODS: We conducted immunoblotting and in vivo microdialysis procedures in MA high/low drinking mice, as well as in isogenic C57BL/6J mice that varied in their MA preference/taking, to examine the glutamate underpinnings of MA abuse vulnerability. Neuropharmacological and Homer2 knockdown approaches were also used in C57BL/6J mice to confirm the role for nucleus accumbens (NAC) glutamate/Homer2 expression in MA preference/aversion...
October 13, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27888396/effects-of-administered-ethanol-and-methamphetamine-on-glial-glutamate-transporters-in-rat-striatum-and-hippocampus
#13
Fahad S Alshehri, Yusuf S Althobaiti, Youssef Sari
Exposure to ethanol (EtOH) or methamphetamine (MA) can lead to increase in extracellular glutamate concentration in the brain. Although studies from ours showed the effects of EtOH exposure on key glial glutamate transporters, little is known about the effects of sequential exposure to EtOH and MA or MA alone on certain glial glutamate transporters. In this study, we investigated the effects of sequential exposure to EtOH and MA on the expression of the major glutamate transporters, glutamate transporter 1 (GLT-1), as well as cystine/glutamate antiporter (xCT) and glutamate aspartate transporter (GLAST) in striatum and hippocampus...
November 25, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27888283/retrograde-conditioning-of-place-preference-and-motor-activity-with-cocaine-in-mice
#14
Ritu A Shetty, Margaret A Rutledge, Michael J Forster
RATIONALE: In order to improve understanding of the nature of drug-associated memory, the current studies addressed whether conditioned place preference (CPP) could develop under conditions in which there was a delay between presentation of context and drug exposure (i.e., retrograde or trace conditioning). OBJECTIVES: The objective was to assess development of CPP when cocaine or methamphetamine was injected simultaneously with exposure to a salient context (S+), or after delays differing in length...
November 25, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27888120/gestational-exposure-to-perfluorooctanoic-acid-pfoa-alterations-in-motor-related-behaviors
#15
David R Goulding, Sally S White, Sandra J McBride, Suzanne E Fenton, G Jean Harry
Perfluoroalkyl and polyfluoroalkyl substances are used in commercial applications and developmental exposure has been implicated in alterations in neurobehavioral functioning. While associations between developmental perfluorooctanoic acid (PFOA) exposure and human outcomes have been inconsistent, studies in experimental animals suggest alterations in motor related behaviors. To examine a dose-response pattern of neurobehavioral effects following gestational exposure to PFOA, pregnant CD-1 mice received PFOA (0, 0...
November 22, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/27887830/drugs-of-abuse-and-their-metabolites-in-the-urban-rivers-of-beijing-china-occurrence-distribution-and-potential-environmental-risk
#16
Yan Zhang, Tingting Zhang, Changsheng Guo, Jiapei Lv, Zhendong Hua, Song Hou, Yuan Zhang, Wei Meng, Jian Xu
The occurrence and distribution of five drugs of abuse and their metabolites, namely, methamphetamine (METH), amphetamine (AMP), ketamine (KET), ephedrine (EPH), and hydroxylimine (HY), were investigated in the surface water in urban rivers in Beijing, China. A total of 117 surface water samples were collected from the seven rivers in the Beijing urban areas during four different seasons. Laboratory analyses revealed that EPH and METH were the most predominant drugs, with detection frequency ranging from 94% to 100% and from 65% to 100%, respectively...
November 22, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27884570/a-gc-ms-method-for-the-detection-and-quantitation-of-ten-major-drugs-of-abuse-in-human-hair-samples
#17
A Orfanidis, O Mastrogianni, A Koukou, G Psarros, H Gika, G Theodoridis, N Raikos
A sensitive analytical method has been developed in order to identify and quantify major drugs of abuse (DOA), namely morphine, codeine, 6-monoacetylmorphine, cocaine, ecgonine methyl ester, benzoylecgonine, amphetamine, methamphetamine, methylenedioxymethamphetamine and methylenedioxyamphetamine in human hair. Samples of hair were extracted with methanol under ultrasonication at 50°C after a three step rinsing process to remove external contamination and dirt hair. Derivatization with BSTFA was selected in order to increase detection sensitivity of GC/MS analysis...
November 10, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27881347/-effect-of-rhynchophylline-on-behaviors-of-methamphetamine-dependent-zebrafish-and-the-mechanism
#18
Yi-Fei Chen, Ju Peng, Miao Fang, Yi Liu, Ling-Hui Nie, Zhi-Xian Mo, Ling-Ling Zhu
OBJECTIVE: To observe the effect of rhynchophylline on methamphetamine-dependent zebrafish and explore the possible mechanism. METHODS: Zebrafish were divided into control group, amphetamine group, low- (50 mg/kg) and high (100 mg/kg)-dose rhynchophylline groups, and ketamine (150 mg/kg) group. Conditioned place preference (CPP) was induced in zebrafish with methamphetamine, and the staying time in the drug box and the tracking map of the zebrafish were observed with Noldus Ethovision XT system...
November 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27869867/detection-and-identification-of-drugs-under-real-conditions-by-using-noisy-terahertz-broadband-pulse
#19
Vyacheslav A Trofimov, Svetlana A Varentsova
We discuss an effective method for detecting and identifying drugs using a high-noise terahertz (THz) signal. We add a noisy THz signal obtained in real conditions to the THz signal transmitted through a sample with the illicit drug methamphetamine. The insufficiency of the standard THz time-domain spectroscopy method is demonstrated, showing that this method detects the spectral features of neutral substances and explosives in a noisy THz signal. The method discussed is based upon time-dependent integral correlation criteria calculated using spectral dynamics of the medium response...
November 20, 2016: Applied Optics
https://www.readbyqxmd.com/read/27869204/mrna-changes-in-nucleus-accumbens-related-to-methamphetamine-addiction-in-mice
#20
Li Zhu, Jiaqi Li, Nan Dong, Fanglin Guan, Yufeng Liu, Dongliang Ma, Eyleen L K Goh, Teng Chen
Methamphetamine (METH) is a highly addictive psychostimulant that elicits aberrant changes in the expression of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in the nucleus accumbens of mice, indicating a potential role of METH in post-transcriptional regulations. To decipher the potential consequences of these post-transcriptional regulations in response to METH, we performed strand-specific RNA sequencing (ssRNA-Seq) to identify alterations in mRNA expression and their alternative splicing in the nucleus accumbens of mice following exposure to METH...
November 21, 2016: Scientific Reports
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