Alissa M D'Gama, Sarah Mulhern, Beth R Sheidley, Fadil Boodhoo, Sarah Buts, Natalie J Chandler, Joanna Cobb, Meredith Curtis, Edward J Higginbotham, Jonathon Holland, Tayyaba Khan, Julia Koh, Nicole S Y Liang, Lyndsey McRae, Sarah E Nesbitt, Brandon T Oby, Ben Paternoster, Alistair Patton, Graham Rose, Elizabeth Scotchman, Rozalia Valentine, Kimberly N Wiltrout, Robin Z Hayeems, Puneet Jain, Sebastian Lunke, Christian R Marshall, Shira Rockowitz, Neil J Sebire, Zornitza Stark, Susan M White, Lyn S Chitty, J Helen Cross, Ingrid E Scheffer, Vann Chau, Gregory Costain, Annapurna Poduri, Katherine B Howell, Amy McTague
BACKGROUND: Most neonatal and infantile-onset epilepsies have presumed genetic aetiologies, and early genetic diagnoses have the potential to inform clinical management and improve outcomes. We therefore aimed to determine the feasibility, diagnostic yield, and clinical utility of rapid genome sequencing in this population. METHODS: We conducted an international, multicentre, cohort study (Gene-STEPS), which is a pilot study of the International Precision Child Health Partnership (IPCHiP)...
September 2023: Lancet Neurology