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https://www.readbyqxmd.com/read/28434027/can-ultrasound-be-used-as-the-primary-imaging-in-children-with-suspected-crohn-disease
#1
Timothy L Tsai, Megan B Marine, Matthew R Wanner, Matthew L Cooper, Steven J Steiner, Fangqian Ouyang, S Gregory Jennings, Boaz Karmazyn
BACKGROUND: There is growing literature on the use of ultrasound (US) for evaluation of Crohn disease in adults, but few studies have been conducted on children. Several studies demonstrated high accuracy of US in the diagnosis of Crohn disease. Using US as the primary screening imaging modality for Crohn disease can reduce health care costs, the need for sedation and ionizing radiation exposure. OBJECTIVE: The aim of our study is to determine if US can be used for screening evaluation of pediatric Crohn disease...
April 22, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28417181/colonic-inflammation-in-pediatric-inflammatory-bowel-disease-detection-with-magnetic-resonance-enterography
#2
Alessandro Campari, Marcello Napolitano, Giovanna Zuin, Luciano Maestri, Giovanni Di Leo, Francesco Sardanelli
BACKGROUND: Colonic involvement in pediatric inflammatory bowel disease is common. Magnetic resonance (MR) enterography is considered the best imaging modality for pediatric inflammatory bowel disease evaluation. It is unclear whether the lack of a dedicated large bowel preparation prevents a reliable colonic assessment. OBJECTIVE: To determine the diagnostic performance of standard MR enterography in detecting and grading colonic inflammatory activity. MATERIALS AND METHODS: We retrospectively evaluated children who underwent both MR enterography and ileocolonoscopy with biopsies <4 weeks apart...
April 17, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28416240/efficacy-of-tumour-necrosis-factor-antagonists-in-stricturing-crohn-s-disease-a-tertiary-center-real-life-experience
#3
Mariangela Allocca, Cristiana Bonifacio, Gionata Fiorino, Antonino Spinelli, Federica Furfaro, Luca Balzarini, Stefanos Bonovas, Silvio Danese
BACKGROUND: Stenosis is the most common complication of Crohn's disease (CD). Long-term outcome of patients receiving tumour necrosis factor (TNF) antagonists for such disease complication is poorly understood. METHODS: 51 CD patients (from July 2006 to November 2015) who had a diagnosis of small bowel or colonic stenosis, diagnosed by colonoscopy and/or MRI enterography, and were treated with TNF antagonists (adalimumab or infliximab) were enrolled. The primary outcome was to assess the rate of success of TNF antagonists on avoiding abdominal surgery for stricturing CD patients...
March 30, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28401775/semi-automatic-bowel-wall-thickness-measurements-on-mr-enterography-in-patients-with-crohn-s-disease
#4
R E Naziroglu, C A J Puylaert, J A W Tielbeek, J C Makanyanga, A Menys, C Y Ponsioen, H Hatzakis, S A Taylor, J Stoker, L J van Vliet, F M Vos
OBJECTIVE: To evaluate a semi-automatic method for delineation of the bowel wall and measurement of the wall thickness in patients with Crohn's disease. METHODS: Fifty-three patients with suspected or proven Crohn's disease were selected. Two radiologists independently supervised the delineation of regions with active Crohn's disease on MRI, yielding manual annotations (Ano1, Ano2). Three observers manually measured the maximal bowel wall thickness of each annotated segment...
April 12, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28393302/shortened-oral-contrast-preparation-for-improved-small-bowel-distension-at-mr-enterography
#5
M I J Bekendam, C A J Puylaert, S K S S Phoa, C Y Nio, J Stoker
PURPOSE: Adequate small bowel distension in MR enterography is important for the evaluation of disease activity in Crohn's disease patients. While distension of the distal small bowel can be achieved using standard oral contrast preparation, proximal small bowel distension remains a common impediment. The aim of this study was to compare small bowel distension between a 60-min oral contrast preparation and a 45-min oral contrast preparation. METHODS: Fifty retrospectively included patients with a 60-min oral preparation protocol and 50 prospectively included patients with a 45-min three-portion oral preparation protocol were included in the study...
April 9, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28393301/structured-reporting-of-ct%C3%A2-enterography%C3%A2-for%C3%A2-inflammatory-bowel-disease-effect-on-key-feature%C3%A2-reporting-accuracy-across-training-levels-and-subjective-assessment-of-disease-by-referring-physicians
#6
Benjamin Wildman-Tobriner, Brian C Allen, Mustafa R Bashir, Morgan Camp, Chad Miller, Lauren E Fiorillo, Alan Cubre, Sanaz Javadi, Alex D Bibbey, Wendy L Ehieli, Nancy McGreal, Reinaldo Quevedo, Julie K Thacker, Maciej Mazurowski, Tracy A Jaffe
PURPOSE: To compare the content and accuracy of structured reporting (SR) versus non-structured reporting (NSR) for computed tomographic enterography (CTE) of inflammatory bowel disease (IBD). MATERIALS AND METHODS: This IRB-approved, HIPAA-compliant, retrospective study included 30 adult subjects (15 male, 15 female; mean age 41.9 years) with IBD imaged with CTE. Nine radiologists (3 faculty, 3 abdominal imaging fellows, and 3 senior radiology residents) independently interpreted all examinations using both NSR and SR, separated by four weeks...
April 9, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28386628/paediatric-magnetic-resonance-enteroclysis-under-general-anaesthesia-initial-experience
#7
Sophie Sadigh, Mark Chopra, Michael R Sury, Neil Shah, Øystein E Olsen, Tom A Watson
MR enterography is the accepted imaging reference standard for small bowel assessment in inflammatory bowel disease. There is an increasing cohort of children with inflammatory bowel disease presenting at an early age (<5 years) with severe disease. Younger children present a technical challenge for enterography because of the need for sedation/general anaesthesia to allow image optimisation and the need for oral contrast to allow adequate luminal assessment. Through our experiences, MR enteroclysis under general anaesthesia has proven to be a successful imaging technique for the work-up of these patients...
April 6, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28379745/endoscopic-skipping-of-the-terminal-ileum-in-pediatric-crohn-disease
#8
Ishrat Mansuri, Joel G Fletcher, David H Bruining, Amy B Kolbe, Jeff L Fidler, Sunil Samuel, Jeanne Tung
OBJECTIVE: Pediatric small-bowel (SB) Crohn disease (CD) may be missed if the terminal ileum (TI) appears normal at endoscopy and SB imaging is not performed. We sought to estimate the prevalence and clinical characteristics of pediatric patients with CD and endoscopic skipping of the TI-that is, pediatric patients with active SB or upper gut inflammation and an endoscopically normal TI. MATERIALS AND METHODS: This retrospective study included pediatric patients with CD who underwent both CT enterography (CTE) or MR enterography (MRE) and ileocolonoscopy within a 30-day period between July 2004 and April 2014...
April 5, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28362690/perianal-pediatric-crohn-s-disease-is-associated-with-a-distinct-phenotype-and-greater-inflammatory-burden
#9
Amit Assa, Michal Amitai, Mary-Louise Greer, Denise A Castro, Ruth Cytter Kuint, Maria Martínez-León, Izabela Herman-Sucharska, Eva Coppenrath, Sudha Anupindi, Alexander Towbin, Douglas Moote, Osnat Konen, Li-Tal Pratt, Anne Griffiths, Dan Turner
BACKGROUND: Data on the outcomes of children with perianal Crohn's disease (pCD) are limited, although its presence is often used for justifying early use of biologics. We aimed to assess whether pCD in children is associated with more severe outcomes as found in adults. METHODS: Data were extracted from the ImageKids database, a prospective, multicenter, longitudinal cohort study. The study enrolled 246 children at disease onset or thereafter. All patients underwent comprehensive clinical, endoscopic, and radiologic evaluation at enrollment; 98 children had repeat evaluation at 18 months...
March 30, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28347526/the-role-of-imaging-in-the-preoperative-assessment-of-children-with-inflammatory-colitis
#10
Natashia M Seemann, Shilpa Radhakrishnan, Aaron Gazendam, Sebastian K King, Michelle Falkiner, Nicholas Shkumat, Mary-Louise C Greer, Jacob C Langer
BACKGROUND: Accurate diagnosis of Crohn's disease or ulcerative colitis is essential for surgical planning. This study compared the accuracy, safety, and utility of small bowel follow-through (SBFT) and magnetic resonance enterography (MRE) for detecting small bowel (SB) involvement preoperatively. METHODS: A retrospective review of children who underwent colectomy for inflammatory bowel disease (2000-2014) was performed. Preoperative SBFT and MRE were independently reviewed by two radiologists blinded to clinical data...
March 18, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28343151/gastric-outlet-obstruction-an-unusual-case-of-primary-duodenal-tuberculosis
#11
Sanket Kalpande, Jayashri Sanjay Pandya, Ajeet Tiwari, Devbrata Adhikari
BACKGROUND: Tuberculosis is a major health problem worldwide. Gastrointestinal tuberculosis presenting as isolated involvement of the duodenum is a rare case. CASE PRESENTATION: A 13 year male, presented with features of gastric outlet obstruction. CT enterography scan showed circumferential mural thickening in first and second part of duodenal junction causing luminal narrowing. Upper GI endoscopy confirmed the narrowing of D1-D2 junction. Duodenal biopsy showed duodenitis with negative result for AFB stain, Helicobacter Pylori...
March 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28334618/is-there-a-role-of-magnetic-resonance-imaging-in-deciding-to-stop-anti-tumor-necrosis-factor-treatment-in-ileal-crohn-s-disease
#12
Jose C Gallego, Ana Echarri
PURPOSE: This study was performed to assess the ability of magnetic resonance enterography to predict the evolution of patients in whom anti-tumor necrosis factor-α therapy was suspended. METHODS: A prospective study of patients with ileal Crohn's disease was performed. RESULTS: Twenty-nine patients were included. Patients who later relapsed showed higher magnetic resonance scores than those who did not relapse (4.2 vs. 2.5, respectively; p<0...
March 16, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28302273/there-is-good-agreement-between-mr-enterography-and-bowel-ultrasound-with-regards-to-disease-location-and-activity-in-paediatric-inflammatory-bowel-disease
#13
J L Barber, J Maclachlan, K Planche, M Furman, D Crespi, N Bab, I Beal
AIM: To investigate concordance of bowel ultrasound and magnetic resonance enterography (MRE) in identifying active disease in children with inflammatory bowel disease. MATERIALS AND METHODS: The imaging of children with inflammatory bowel disease who had undergone bowel ultrasound and MRE within 30 days were retrospectively reviewed, from January 2009 to November 2015. Ultrasound was without oral contrast medium; MRI was conducted with patients unsedated with oral contrast medium and gadolinium...
March 14, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28298964/magnetic-resonance-enterography-in-crohn-s-disease-how-we-do-it-and-common-imaging-findings
#14
REVIEW
Annalisa Mantarro, Paola Scalise, Elisa Guidi, Emanuele Neri
Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract, with unpredictable clinical course by phases of relapses alternating with other of quiescence. The etiology is multifactorial and is still not completely known; globally the westernization of lifestyle is causing an increasing incidence of CD, with peak age of 20-30 years. The diagnostic workup begins with the evaluation of the clinical history, physical examination and laboratory tests. However, the clinical assessment is subjected interobserver variability and, occasionally, the symptoms of acute and chronic inflammation may be indistinguishable...
February 28, 2017: World Journal of Radiology
https://www.readbyqxmd.com/read/28298727/using-computed-tomography-enterography-to-evaluate-patients-with-crohn-s-disease-what-impact-does-examiner-experience-have-on-the-reproducibility-of-the-method
#15
Stênio Burlin, Larissa Rossini Favaro, Elisa Almeida Sathler Bretas, Lincoln Seiji Taniguchi, Ana Paula Loch, Marjorie Costa Argollo, Orlando Ambrogini Junior, Giuseppe D'Ippolito
OBJECTIVE: To assess the impact that examiner experience has on the reproducibility and accuracy of computed tomography (CT) enterography in the detection of radiological signs in patients with Crohn's disease. MATERIALS AND METHODS: This was a retrospective, cross-sectional observational study involving the analysis of CT enterography scans of 20 patients with Crohn's disease. The exams were analyzed independently by two radiologists in their last year of residence (duo I) and by two abdominal imaging specialists (duo II)...
January 2017: Radiologia Brasileira
https://www.readbyqxmd.com/read/28292640/cross-sectional-evaluation-of-transmural-healing-in-patients-with-crohn-s-disease-on-maintenance-treatment-with-anti-tnf-alpha-agents
#16
Fabiana Castiglione, Pierpaolo Mainenti, Anna Testa, Nicola Imperatore, Giovanni Domenico De Palma, Matilde Rea, Olga Maria Nardone, Marco Sanges, Nicola Caporaso, Antonio Rispo
BACKGROUND: Transmural healing (TH) of Crohn's disease (CD) is a still unexplored and interesting outcome correlated to concept of deep remission. AIM: To assess the rate of TH in CD patients treated with anti-TNF alpha agents using two cross-sectional procedures: bowel sonography (BS) and magnetic resonance enterography (MRE). METHODS: We performed a 2-year observational longitudinal study, evaluating steroid-free clinical remission (CR), mucosal healing (MH), and TH in CD patients who would complete a 2-year treatment period with anti-TNFs...
February 28, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28286879/dynamic-contrast-enhanced-magnetic-resonance-enterography-and-dynamic-contrast-enhanced-ultrasonography-in-crohn-s-disease-an-observational-comparison-study
#17
Rune Wilkens, David A Peters, Agnete H Nielsen, Valeriya P Hovgaard, Henning Glerup, Klaus Krogh
Purpose e Cross-sectional imaging methods are important for objective evaluationof small intestinal inflammationinCrohn'sdisease(CD).The primary aim was to compare relative parameters of intestinal perfusion between contrast-enhanced ultrasonography (CEUS) and dynamic contrast-enhanced magnetic resonance enterography (DCE-MRE) in CD. Furthermore, we aimed at testing the repeatability of regions of interest (ROIs) for CEUS. Methods This prospective study included 25 patients: 12 females (age: 37, range: 19-66) with moderate to severe CD and a bowel wall thickness>3mm evaluated with DCE-MRE and CEUS...
February 2017: Ultrasound International Open
https://www.readbyqxmd.com/read/28283726/magnetic-resonance-enterography-has-good-inter-rater-agreement-and-diagnostic-accuracy-for-detecting-inflammation-in-pediatric-crohn-disease
#18
Peter C Church, Mary-Louise C Greer, Ruth Cytter-Kuint, Andrea S Doria, Anne M Griffiths, Dan Turner, Thomas D Walters, Brian M Feldman
BACKGROUND: Magnetic resonance enterography (MRE) is increasingly relied upon for noninvasive assessment of intestinal inflammation in Crohn disease. However very few studies have examined the diagnostic accuracy of individual MRE signs in children. OBJECTIVE: We have created an MR-based multi-item measure of intestinal inflammation in children with Crohn disease - the Pediatric Inflammatory Crohn's MRE Index (PICMI). To inform item selection for this instrument, we explored the inter-rater agreement and diagnostic accuracy of individual MRE signs of inflammation in pediatric Crohn disease and compared our findings with the reference standards of the weighted Pediatric Crohn's Disease Activity Index (wPCDAI) and C-reactive protein (CRP)...
May 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28267043/a-fixed-stricture-on-routine-cross-sectional-imaging-predicts-disease-related-complications-and-adverse-outcomes-in-patients-with-crohn-s-disease
#19
Naueen A Chaudhry, Michael Riverso, Joseph R Grajo, Patricia P Moser, Fei Zou, Maher Homsi, Darashana R Punglia, Ellen M Zimmermann
BACKGROUND: Patients with Crohn's disease (CD) typically undergo multiple cross-sectional imaging exams including computed tomography and magnetic resonance enterography during the course of their disease. The aim was to identify imaging findings that predict future disease-related poor outcomes. METHODS: This was a retrospective, case control study at a single tertiary center. Cases were CD patients diagnosed with complications (bowel obstruction, perforation, internal fistula, or abscess); controls were CD patients without complications...
April 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28256148/accumulation-of-mesalazine-pills-in-the-medium-ileum-in-a-patient-with-crohn%C3%A2-s-disease
#20
Carmen Martínez Huertas, Paloma Garcia-Villanova Ruiz, José Pozo Sánchez, Cristina Dávila Arias
Crohn´s disease is an inflammatory disease that can involve any portion of the gastrointestinal tract, although terminal ileum is the most commonly affected portion. It is characterized by a transmural and discontinuous distribution pattern, with alternating periods of active disease and remission. We present the case of a 23-year-old patient diagnosed with Crohn´s disease, in treatment with extended release Mesalazine and corticoids. The CT Enterography showed activity signs and a great dilatation of medium ileum with lots of Mesalazine pills accumulated inside...
March 2017: Revista Española de Enfermedades Digestivas
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