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https://www.readbyqxmd.com/read/27374614/z-dna-forming-sites-identified-by-chip-seq-are-associated-with-actively-transcribed-regions-in-the-human-genome
#1
So-I Shin, Seokjin Ham, Jihwan Park, Seong Hye Seo, Chae Hyun Lim, Hyeongrin Jeon, Jounghyun Huh, Tae-Young Roh
Z-DNA, a left-handed double helical DNA is structurally different from the most abundant B-DNA. Z-DNA has been known to play a significant role in transcription and genome stability but the biological meaning and positions of Z-DNA-forming sites (ZFSs) in the human genome has not been fully explored. To obtain genome-wide map of ZFSs, Zaa with two Z-DNA-binding domains was used for ChIP-Seq analysis. A total of 391 ZFSs were found and their functions were examined in vivo A large portion of ZFSs was enriched in the promoter regions and contain sequences with high potential to form Z-DNA...
July 3, 2016: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/27295481/what-motivates-residents-to-teach-the-attitudes-in-clinical-teaching-study
#2
Sarah Dotters-Katz, Charles W Hargett, Aimee K Zaas, Lisa G Criscione-Schreiber
CONTEXT: Graduate medical trainees have a critical role in the teaching of other trainees. Improving their teaching requires an understanding of their attitudes towards teaching and their motivation to teach. Both have been incompletely explored in this population. We aimed to better understand graduate medical trainees' attitudes towards teaching and motivation to teach in the clinical setting in order to inform modifications to resident-as-teacher (RAT) programmes and enhance teaching practices...
July 2016: Medical Education
https://www.readbyqxmd.com/read/27168887/doctor-who-a-quality-improvement-project-to-assess-and-improve-patients-knowledge-of-their-inpatient-physicians
#3
Kathleen Broderick-Forsgren, Wynn G Hunter, Ryan D Schulteis, Wen-Wei Liu, Joel C Boggan, Poonam Sharma, Steven Thomas, Aimee Zaas, Jonathan Bae
Background Patient-physician communication is an integral part of high-quality patient care and an expectation of the Clinical Learning Environment Review program. Objective This quality improvement initiative evaluated the impact of an educational audit and feedback intervention on the frequency of use of 2 tools-business cards and white boards-to improve provider identification. Methods This before-after study utilized patient surveys to determine the ability of those patients to name and recognize their physicians...
May 2016: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/27097051/patients-nurses-and-physicians-working-together-to-develop-a-discharge-entrustable-professional-activity-assessment-tool
#4
Lauren B Meade, Kathleen Heist Suddarth, Ronald R Jones, Aimee K Zaas, Terry Albanese, Kenji Yamazaki, Cheryl W O'Malley
PROBLEM: The Accreditation Council for Graduate Medical Education milestones were written by physicians and thus may not reflect all the behaviors necessary for physicians to optimize their performance as a key member of an interprofessional team. APPROACH: From April to May 2013, the authors, Educational Research Outcomes Collaborative leaders, assembled interprofessional team discussion groups, including patients or family members, nurses, physician trainees, physician educators, and other staff (optional), at 11 internal medicine (IM) programs...
April 19, 2016: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/27086497/factors-associated-with-declining-residency-program-pass-rates-on-the-abim-certification-examination
#5
Lisa L Willett, Andrew J Halvorsen, Michael Adams, Karen M Chacko, Saima Chaudhry, Furman S McDonald, Amy S Oxentenko, Sara L Swenson, Aimee Zaas, Vineet M Arora
No abstract text is available yet for this article.
July 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/26970469/the-2015-international-society-for-heart-and-lung-transplantation-guidelines-for-the-management-of-fungal-infections-in-mechanical-circulatory-support-and-cardiothoracic-organ-transplant-recipients-executive-summary
#6
EDITORIAL
Shahid Husain, Amparo Sole, Barbara D Alexander, Saima Aslam, Robin Avery, Christian Benden, Eliane M Billaud, Daniel Chambers, Lara Danziger-Isakov, Savitri Fedson, Kate Gould, Aric Gregson, Paolo Grossi, Denis Hadjiliadis, Peter Hopkins, Me-Linh Luong, Debbie J E Marriott, Victor Monforte, Patricia Muñoz, Alessandro C Pasqualotto, Antonio Roman, Fernanda P Silveira, Jeffrey Teuteberg, Stephen Weigt, Aimee K Zaas, Andreas Zuckerman, Orla Morrissey
No abstract text is available yet for this article.
March 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/26933666/a-genomic-signature-of-influenza-infection-shows-potential-for-presymptomatic-detection-guiding-early-therapy-and-monitoring-clinical-responses
#7
Micah T McClain, Bradly P Nicholson, Lawrence P Park, Tzu-Yu Liu, Alfred O Hero, Ephraim L Tsalik, Aimee K Zaas, Timothy Veldman, Lori L Hudson, Robert Lambkin-Williams, Anthony Gilbert, Thomas Burke, Marshall Nichols, Geoffrey S Ginsburg, Christopher W Woods
Early, presymptomatic intervention with oseltamivir (corresponding to the onset of a published host-based genomic signature of influenza infection) resulted in decreased overall influenza symptoms (aggregate symptom scores of 23.5 vs 46.3), more rapid resolution of clinical disease (20 hours earlier), reduced viral shedding (total median tissue culture infectious dose [TCID50] 7.4 vs 9.7), and significantly reduced expression of several inflammatory cytokines (interferon-γ, tumor necrosis factor-α, interleukin-6, and others)...
January 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/26917807/the-burden-of-burnout-an-assessment-of-burnout-among-internal-medicine-residents-after-the-2011-duty-hour-changes
#8
Hany Elmariah, Samantha Thomas, Joel C Boggan, Aimee Zaas, Jonathan Bae
This study sought to determine burnout prevalence and factors associated with burnout in internal medicine residents after introduction of the 2011 ACGME duty hour rules. Burnout was evaluated using an anonymized, abbreviated version of the Maslach Burnout Inventory. Surveys were collected biweekly for 48 weeks during the 2013-2014 academic year. Burnout severity was compared across subgroups and time. A score of 3 or higher signified burnout. Overall, 944 of 3936 (24%) surveys were completed. The mean burnout score across all surveys was 2...
February 25, 2016: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://www.readbyqxmd.com/read/26901111/implementation-of-milestones-based-assessment-for-a-safe-and-effective-discharge
#9
Kathleen Heist Suddarth, Ronald R Jones, Cheryl W O'Malley, David Paje, Kenji Yamazaki, Aimee K Zaas, Lauren B Meade
No abstract text is available yet for this article.
June 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/26801061/an-individualized-predictor-of-health-and-disease-using-paired-reference-and-target-samples
#10
Tzu-Yu Liu, Thomas Burke, Lawrence P Park, Christopher W Woods, Aimee K Zaas, Geoffrey S Ginsburg, Alfred O Hero
BACKGROUND: Consider the problem of designing a panel of complex biomarkers to predict a patient's health or disease state when one can pair his or her current test sample, called a target sample, with the patient's previously acquired healthy sample, called a reference sample. As contrasted to a population averaged reference this reference sample is individualized. Automated predictor algorithms that compare and contrast the paired samples to each other could result in a new generation of test panels that compare to a person's healthy reference to enhance predictive accuracy...
2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/26791949/host-gene-expression-classifiers-diagnose-acute-respiratory-illness-etiology
#11
Ephraim L Tsalik, Ricardo Henao, Marshall Nichols, Thomas Burke, Emily R Ko, Micah T McClain, Lori L Hudson, Anna Mazur, Debra H Freeman, Tim Veldman, Raymond J Langley, Eugenia B Quackenbush, Seth W Glickman, Charles B Cairns, Anja K Jaehne, Emanuel P Rivers, Ronny M Otero, Aimee K Zaas, Stephen F Kingsmore, Joseph Lucas, Vance G Fowler, Lawrence Carin, Geoffrey S Ginsburg, Christopher W Woods
Acute respiratory infections caused by bacterial or viral pathogens are among the most common reasons for seeking medical care. Despite improvements in pathogen-based diagnostics, most patients receive inappropriate antibiotics. Host response biomarkers offer an alternative diagnostic approach to direct antimicrobial use. This observational cohort study determined whether host gene expression patterns discriminate noninfectious from infectious illness and bacterial from viral causes of acute respiratory infection in the acute care setting...
January 20, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/26602515/diabetes-quality-of-care-before-and-after-implementation-of-a-resident-clinic-practice-partnership-system
#12
Elizabeth A Campbell, Matthew J Crowley, Benjamin J Powers, Linda L Sanders, Maren K Olsen, Susanne Danus, Diana B McNeill, Aimee K Zaas
Deficiencies in resident diabetes care quality may relate to continuity clinic design. This retrospective analysis compared diabetes care processes and outcomes within a traditional resident continuity clinic structure (2005) and after the implementation of a practice partnership system (PPS; 2009). Under PPS, patients were more likely to receive annual foot examinations (odds ratio [OR] = 11.6; 95% confidence interval [CI] = 7.2, 18.5), microalbumin screening (OR = 2.4; 95% CI = 1.6, 3.4), and aspirin use counseling (OR = 3...
November 24, 2015: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://www.readbyqxmd.com/read/26279782/a-novel-approach-to-practice-based-learning-and-improvement-using-a-web-based-audit-and-feedback-module
#13
Joel C Boggan, George Cheely, Bimal R Shah, Randy Heffelfinger, Deanna Springall, Samantha M Thomas, Aimee Zaas, Jonathan Bae
BACKGROUND: Systematically engaging residents in large programs in quality improvement (QI) is challenging. OBJECTIVE: To coordinate a shared QI project in a large residency program using an online tool. METHODS: A web-based QI tool guided residents through a 2-phase evaluation of performance of foot examinations in patients with diabetes. In phase 1, residents completed reviews of health records with online data entry. Residents were then presented with personal performance data relative to peers and were prompted to develop improvement plans...
September 2014: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/26264415/economic-outcomes-of-extracorporeal-membrane-oxygenation-with-and-without-ambulation-as-a-bridge-to-lung-transplantation
#14
Jesse C Bain, David A Turner, Kyle J Rehder, Eric L Eisenstein, R Duane Davis, Ira M Cheifetz, David W Zaas
BACKGROUND: An increasing number of centers are using active rehabilitation and ambulation for critically ill patients on extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation. This investigation assessed the economic impact at a single center of ambulatory versus non-ambulatory ECMO strategies as a bridge to lung transplantation. METHODS: We conducted a single-center retrospective cohort analysis of all subjects supported with ECMO as a bridge to lung transplantation (N = 9) from 2007 to 2012...
January 2016: Respiratory Care
https://www.readbyqxmd.com/read/26193668/gene-expression-profiles-link-respiratory-viral-infection-platelet-response-to-aspirin-and-acute-myocardial-infarction
#15
Jason J Rose, Deepak Voora, Derek D Cyr, Joseph E Lucas, Aimee K Zaas, Christopher W Woods, L Kristin Newby, William E Kraus, Geoffrey S Ginsburg
BACKGROUND: Influenza infection is associated with myocardial infarction (MI), suggesting that respiratory viral infection may induce biologic pathways that contribute to MI. We tested the hypotheses that 1) a validated blood gene expression signature of respiratory viral infection (viral GES) was associated with MI and 2) respiratory viral exposure changes levels of a validated platelet gene expression signature (platelet GES) of platelet function in response to aspirin that is associated with MI...
2015: PloS One
https://www.readbyqxmd.com/read/26029081/the-effect-of-transcranial-direct-current-stimulation-on-the-expression-of-the-flexor-synergy-in-the-paretic-arm-in-chronic-stroke-is-dependent-on-shoulder-abduction-loading
#16
Jun Yao, Justin Drogos, Fleur Veltink, Caitlyn Anderson, Janny Concha Urday Zaa, Laura Imming Hanson, Julius P A Dewald
Reaching ability of the paretic upper extremity in individuals with stroke decreases with increased shoulder abduction (SABD) loads. Transcranial direct current stimulation (tDCS) has been implemented to improve movement ability following stroke. However, results from previous studies vary, perhaps due to the influence of impairment level and the type of motor tasks that were used to study the effects of tDCS. This study specifically examines the impact of SABD loading on the effects of tDCS in 9 individuals with moderate to severe chronic stroke...
2015: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/26021815/fool-me-once-fool-me-twice-hypertrophic-cardiomyopathy-with-aortic-stenosis
#17
Christopher Vanichsarn, Robert James Siegel
No abstract text is available yet for this article.
October 2015: American Journal of Medicine
https://www.readbyqxmd.com/read/26007673/rewriting-history-fever-of-unknown-origin
#18
Jenna R Bordelon, Syeda U Abbas, Arsalan Q Shabbir, Andrew L Ross
No abstract text is available yet for this article.
September 2015: American Journal of Medicine
https://www.readbyqxmd.com/read/25940249/ambulatory-extracorporeal-membrane-oxygenation-as-a-bridge-to-lung-transplantation-walking-while-waiting
#19
REVIEW
Carli J Lehr, David W Zaas, Ira M Cheifetz, David A Turner
The proportion of critically ill patients awaiting lung transplantation has increased since the implementation of the Lung Allocation Score (LAS) in 2005. Critically ill patients comprise a sizable proportion of wait-list mortality and are known to experience increased posttransplant complications. These critically ill patients have been successfully bridged to lung transplantation with extracorporeal membrane oxygenation (ECMO), but historically these patients have required excessive sedation, been immobile, and have had difficult functional recovery in the posttransplant period and high mortality...
May 2015: Chest
https://www.readbyqxmd.com/read/25912202/getting-the-whole-picture-lymphangitic-carcinomatosis
#20
Abhishek Biswas, Peruvemba S Sriram
No abstract text is available yet for this article.
August 2015: American Journal of Medicine
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