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https://www.readbyqxmd.com/read/28240096/role-of-%C3%AE-2-microglobulin-in-postoperative-cognitive-decline
#1
Marta Załęska-Kocięcka, Paweł Jezierski, Maciej Grabowski, Krzysztof Kuśmierski, Maciej Dąbrowski, Katarzyna Piotrowska, Marek Banaszewski, Jacek Imiela, Janina Stępińska
AIM: β2-microglobulin (β2M) was proved to affect hippocampal functions in mice. MATERIALS & METHODS: Seventy-one patients undergoing aortic valve replacement were analyzed in prospective observational study. Kidney biomarkers and Mini Mental State Examinations (MMSEs) were performed before procedure, at discharge and after 6 months. RESULTS: Patients with β2M increase over the median change (>0.42 mg/l) experienced a significant in-hospital drop in MMSE (p = 0...
March 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28230589/effects-of-local-and-systemic-zoledronic-acid-application-on-titanium-implant-osseointegration-an-experimental-study-conducted-on-two-surface-types
#2
Serkan Dundar, Ferhan Yaman, Orhan Gecor, Omer Cakmak, Mustafa Kirtay, Tuba Talo Yildirim, Tahir Karaman, Mehmet Emre Benlidayi
The aim of this study was to evaluate the effects of local and systemic zoledronic acid (ZA) applications on titaniumoksit ceramic blasted (TiO-CB)- and sandblasted large acid-grit (SLA)-surfaced titanium implant osseointegration. Twelve New Zealand White rabbits were used in the study, divided into 6 groups: the TiO-CB (TiO-CB-CNT) (n = 2) and SLA (SLA-CNT) (n = 2) control groups in which TiO-CB- and SLA-surfaced titanium implants were surgically inserted into rabbit tibias but no treatment was applied; the TiO-CB (TiO-CB-LZA) (n = 2) and SLA (SLA-LZA) (n = 2) local ZA groups in which 1 mL of normal saline solution containing 2 mg of ZA was injected into sockets and after this the implants were integrated; and the TiO-CB (TiO-CB-SZA) (n = 2) and SLA (SLA-SZA) (n = 2) systemic ZA groups in which a single infusion of 0...
February 22, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28220258/impact-of-denosumab-use-on-the-survival-of-untreated-non-squamous-non-small-cell-lung-cancer-patients-with-bone-metastases
#3
Hibiki Udagawa, Seiji Niho, Keisuke Kirita, Shigeki Umemura, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto
PURPOSE: Denosumab reduces the incidence of skeletal-related events (SREs) in solid tumor patients with bone metastases (BM). However, there have been no detailed reports of the efficacy of denosumab in untreated non-squamous non-small cell lung cancer (NSCLC) patients with BM. METHODS: The medical records of patients with untreated non-squamous NSCLC and BM at diagnosis at our institution were reviewed retrospectively. The overall survival (OS) and the time to SREs were analyzed according to the treatment for the BM...
February 20, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28214773/the-usefulness-of-bone-biomarkers-for-monitoring-treatment-disease-a-comparative-study-in-osteolytic-and-osteosclerotic-bone-metastasis-models
#4
Marta Martín-Fernández, Karmele Valencia, Carolina Zandueta, Cristina Ormazábal, Susana Martínez-Canarias, Fernando Lecanda, Concepción de la Piedra
BACKGROUND: The skeleton is the most common site of colonization by metastatic cancers. Zoledronic acid (ZA) has been shown to be effective for the treatment of bone metastases regardless of whether the bone lesions are osteolytic or osteoblastic. Biochemical markers of bone turnover may be useful tools to quantify the degree of bone remodeling in the presence of bone metastases. The aim of this work was to establish the correlation between tumor dispersion (bioluminescence) and biochemical markers of bone turnover in two osteolytic and osteoblastic metastasis models in mice...
February 16, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28182104/phytoconstituents-and-nutritional-properties-of-the-fruits-of-eleutherococcus-divaricatus-and-eleutherococcus-sessiliflorus-a-study-of-non-european-species-cultivated-in-poland
#5
Daniel Załuski, Marta Olech, Robert Verpoorte, Inamullah Khan, Rafał Kuźniewski, Renata Nowak
Eleutherococcus fruits have been consumed in Russia and Asia throughout the centuries. Currently, there is an increasing interest in these products by the community of Western Europe. Many people suffer from micronutrient deficiencies, known as malnutrition, which consequently influences body condition. The aim of this study was to investigate pharmaconutrition, proximate, mineral, and fatty acid composition, total phenolics content, and total flavonoids content of Eleutherococcus divaricatus and Eleutherococcus sessiliflorus fruits cultivated in Poland...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28171719/nano-hydroxyapatite-bone-substitute-functionalized-with-bone-active-molecules-for-enhanced-cranial-bone-regeneration
#6
Arun Kumar Teotia, Deepak Bushan Raina, Chandan Singh, Neeraj Sinha, Hanna Isaksson, Magnus Tägil, Lars Lidgren, Ashok Kumar
The aim of this study was to synthesize and characterize a nano-hydroxyapatite (nHAP) and calcium sulfate bone substitute (NC) for cranioplasty. The NC was functionalized with low concentrations of bone morphogenetic protein-2 (BMP-2) and zoledronic acid (ZA) and characterized both in vitro and in vivo. In vitro studies included MTT, ALP assays, and fluorescent staining of Saos-2 (human osteoblasts) and MC3T3-E1 (murine preosteoblasts) cells cultured on NC. An in vivo study divided 20 male Wistar rats into four groups: control (defect only), NC, NC + ZA, and NC + ZA + rhBMP-2...
February 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28160593/dental-extraction-following-zoledronate-induces-osteonecrosis-in-rat-s-jaw
#7
X Vidal-Gutiérrez, J-F Gómez-Clavel, L-A Gaitán-Cepeda
BACKGROUND: Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ) is clinically characterized by the presence of exposed bone in the oral cavity that persists for more than eight weeks. Previous attempts to establish an animal model have not sufficiently considered disease features. Our aim was to establish an inexpensive and replicable animal model that develops BRONJ in a short time. MATERIAL AND METHODS: Thirty-two male Wistar rats were randomly divided into two groups: control and experimental...
February 4, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28157087/interface-thermal-conductance-of-van-der-waals-monolayers-on-amorphous-substrates
#8
Gabriela Correa, Cameron Foss, Zlatan Aksamija
Heterostructures based on atomic monolayers are emerging as leading materials for future energy efficient and multifunctional electronics. Due to the single atom thickness of monolayers, their properties are strongly affected by interactions with the external environment. We develop a model for interface thermal conductance (ITC) in an atomic monolayer van der Waals (vdW) bonded to a disordered substrate. Graphene on SiO$_2$ is initially used in our model and contrasted against available experimental data; the model is then applied to monolayer MoS$_2$ on SiO$_2$ substrate...
February 3, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28130238/the-jws-online-simulation-database
#9
Martin Peters, Johann J Eicher, David D van Niekerk, Dagmar Waltemath, Jacky L Snoep
: JWS Online is a web-based platform for construction, simulation and exchange of models in standard formats. We have extended the platform with a database for curated simulation experiments that can be accessed directly via a URL, allowing one-click reproduction of published results. Users can modify the simulation experiments and export them in standard formats. The Simulation database thus lowers the bar on exploring computational models, helps users create valid simulation descriptions and improves the reproducibility of published simulation experiments...
January 27, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28120114/longitudinal-patterns-of-bone-targeted-agent-use-among-patients-with-solid-tumors-and-bone-metastases-in-the-united-states
#10
Yi Qian, Debajyoti Bhowmik, Nandita Kachru, Rohini K Hernandez
PURPOSE: This study examined real-world long-term use of guideline-recommended bone targeted agents (BTA) among patients with metastatic solid tumors. METHODS: Adults with a solid tumor diagnosis followed by a bone metastasis diagnosis in 2012-2014 were identified from electronic medical records in the Oncology Services Comprehensive Electronic Records (OSCER) database. Patients initiated zoledronic acid (ZA) or denosumab on or after the bone metastasis diagnosis and were followed through last clinic visit by 30 June 2015...
January 24, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28106454/search-for-invisible-decays-of-sub-gev-dark-photons-in-missing-energy-events-at-the-cern-sps
#11
D Banerjee, V Burtsev, D Cooke, P Crivelli, E Depero, A V Dermenev, S V Donskov, F Dubinin, R R Dusaev, S Emmenegger, A Fabich, V N Frolov, A Gardikiotis, S N Gninenko, M Hösgen, V A Kachanov, A E Karneyeu, B Ketzer, D V Kirpichnikov, M M Kirsanov, S G Kovalenko, V A Kramarenko, L V Kravchuk, N V Krasnikov, S V Kuleshov, V E Lyubovitskij, V Lysan, V A Matveev, Yu V Mikhailov, V V Myalkovskiy, V D Peshekhonov, D V Peshekhonov, O Petuhov, V A Polyakov, B Radics, A Rubbia, V D Samoylenko, V O Tikhomirov, D A Tlisov, A N Toropin, A Yu Trifonov, B Vasilishin, G Vasquez Arenas, P Ulloa, K Zhukov, K Zioutas
We report on a direct search for sub-GeV dark photons (A^{'}), which might be produced in the reaction e^{-}Z→e^{-}ZA^{'} via kinetic mixing with photons by 100 GeV electrons incident on an active target in the NA64 experiment at the CERN SPS. The dark photons would decay invisibly into dark matter particles resulting in events with large missing energy. No evidence for such decays was found with 2.75×10^{9} electrons on target. We set new limits on the γ-A^{'} mixing strength and exclude the invisible A^{'} with a mass ≲100  MeV as an explanation of the muon g_{μ}-2 anomaly...
January 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28058588/the-hypoglycemic-hypolipidemic-and-anti-diabetic-nephritic-activities-of-zeaxanthin-in-diet-streptozotocin-induced-diabetic-sprague-dawley-rats
#12
Ling Kou, Mingzhao Du, Chaopu Zhang, Zhiyin Dai, Xuan Li, Baohai Zhang
Zeaxanthin (ZA), an important compound found in Lycium barbarum, shows various pharmacodynamic effects. In our present study, a high-fat, high-sucrose diet and streptozotocin (STZ)-induced diabetic rat model was used to investigate the antidiabetic activities of ZA. After a 4-week administration of 200 and 400 mg/kg of ZA and 100 mg/kg of metformin hydrochloride, various blood biochemical indexes were detected. ZA strongly normalized the reduced bodyweight and enhanced fasting blood glucose in diabetic rats...
January 5, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28035042/rock1-but-not-rock2-contributes-to-rhoa-signaling-and-nmiia-mediated-contractility-at-the-epithelial-zonula-adherens
#13
Rashmi Priya, Xuan Liang, Jessica L Teo, Kinga Duszyc, Alpha S Yap, Guillermo A Gomez
Rho kinases (ROCK1 and ROCK2) function downstream of the small GTPase RhoA to drive actomyosin cytoskeletal remodeling. It has often been believed that ROCK1 and ROCK2 may be functionally redundant, as they share a highly conserved kinase domain. However, in this study, we report differential functional effects for these ROCKs at the epithelial zonula adherens (ZA). Using specific siRNA, we found that ROCK1 depletion disrupted cadherin organization at the ZA, accompanied by loss of F-actin and NMIIA, whereas ROCK2 knockdown had no significant effect...
January 1, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28032187/using-telemedicine-to-teach-paediatric-surgery-in-resource-limited-countries
#14
REVIEW
Alp Numanoglu
Halstedian method of surgical training has been the mainstay of surgical education for many decades. Onsite knowledge sources in surgery have traditionally been textbooks, which are often a number of years out of date or teaching rounds with a Professor or senior colleague that enables a small number of trainees to benefit from. Congresses have been a good way of learning new developments in the field, but they often require travelling and are very costly. We have identified web-based education as a means of linking experts with trainees, regardless of their geographic location and often without requiring any substantial capital...
December 28, 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/28030936/association-of-anthropometric-measures-of-obesity-and-chronic-kidney-disease-in-elderly-women
#15
Andrzej Jaroszynski, Tadeusz Dereziński, Anna Jaroszyńska, Tomasz Zapolski, Beata Wąsikowska, Andrzej Wysokiński, Arkadiusz Jawień, Wojciech Załuska, Andrzej Horoch
INTRODUCTION AND OBJECTIVE: Growing evidence suggests that obesity is an important contributor to the development of chronic kidney disease (CKD). The relationship between obesity and CKD is complex and not completely understood, and the best anthropometric index of obesity in predicting CKD is controversial. This study aimed to determine the best anthropometric index of obesity in predicting CKD in a population of elderly women. MATERIALS AND METHODS: Anthropometric indexes of obesity including body mass index (BMI), waist circumference (WC), waist-to-height ratio (WheiR) and waist-to-hip-ratio (WHR), were obtained in 730 selected females...
23, 2016: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28029097/influence-of-silver-content-on-rifampicin-adsorptivity-for-magnetite-ag-rifampicin-nanoparticles
#16
Olena Ivashchenko, Emerson Coy, Barbara Peplinska, Marcin Jarek, Mikołaj Lewandowski, Karol Załęski, Alicja Warowicka, Anna Wozniak, Tatiana Babutina, Justyna Jurga-Stopa, Janez Dolinsek, Stefan Jurga
Magnetite nanoparticles (NPs) decorated with silver (magnetite/Ag) are intensively investigated due to their application in the biomedical field. We demonstrate that the increase of silver content on the surface of nanoparticles improves the adsorptivity of antibiotic rifampicin as well as antibacterial properties. The use of ginger extract allowed to improve the silver nucleation on the magnetite surface that resulted in an increase of silver content. Physicochemical and functional characterization of magnetite/Ag NPs was performed...
February 3, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28018444/compound-heterozygous-mutations-of-acads-gene-in-newborn-with-short-chain-acyl-coa-dehydrogenase-deficiency-case-report-and-literatures-review
#17
Se Jin An, Sook Za Kim, Gu Hwan Kim, Han Wook Yoo, Han Hyuk Lim
Short-chain acyl-CoA dehydrogenase deficiency (SCADD) is a rare autosomal recessive mitochondrial disorder of fatty acid β-oxidation, and is associated with mutations in the acyl-CoA dehydrogenase (ACADS) gene. Recent advances in spectrometric screening for inborn errors of metabolism have helped detect several metabolic disorders, including SCADD, without symptoms in the neonate period. This allows immediate initiation of treatment and monitoring, so they remain largely symptomless metabolic disease. Here, we report a 15-month-old asymptomatic male, who was diagnosed with SCADD by newborn screening...
November 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/28009034/fire-eater-s-lung
#18
Jolanta Załęska, Arkadiusz Błaszczyk, Lilia Jakubowska, Janusz Szopiński, Mateusz Polaczek, Jacek Grudny, Jacek Zych, Kazimierz Roszkowski-Śliż
Fire eater's lung (FEL) is an acute hydrocarbon pneumonitis caused by aspiration or inhalation into airways of liquid hydrocarbons. This disorder is classified into distinct form of chemical toxic pneumonitis. An amateur fire-eater is presented in this work. He accidentally aspirated into airways about 1/3 of glass of grill lighter fluid composed of mixture of liquid hydrocarbons. A few hours after this incident he had severe symptoms like weakness, high temperature, midsternal pleuritic chest pain, myalgia of the back, shortness of breath, and dry cough...
2016: Adv Respir Med
https://www.readbyqxmd.com/read/27997371/first-principles-study-of-thermal-transport-in-nitrogenated-holey-graphene
#19
Tao Ouyang, Huaping Xiao, Chao Tang, Xiaoliang Zhang, Ming Hu, Jianxin Zhong
Nitrogenated holey graphene (NHG), a new two-dimensional graphene variant with a large fundamental direct band gap, has recently been successfully synthesized via a simple wet-chemical reaction. Motivated by its unique geometry and novel properties, we investigated the phonon transport properties of the material by combining first-principle calculations and the phonon Boltzmann transport equation. The lattice thermal conductivity of NHG at room temperature is predicted to be about 82.22 W mK(-1), which is almost two orders of magnitude lower than that of graphene (about 3500 W mK(-1))...
January 27, 2017: Nanotechnology
https://www.readbyqxmd.com/read/27982227/effects-of-zoledronic-acid-on-orthodontic-tooth-movement-in-rats
#20
Marcel Durante Brunet, Cristiano Miranda de Araujo, Aline Cristina Batista Rodrigues Johann, Elisa Souza Camargo, Orlando Motohiro Tanaka, Odilon Guariza
The purpose of this study was to assess the effects of the administration of zoledronic acid (ZA) during orthodontic movement in rats. A hundred and twenty male Wistar rats were applied force of 30 cN with spring closed nickel-titanium to move the upper right first molar to mesial. In the Control Movement group (CM), only tooth movement was performed; the Control Acid Zoledronic group (CAZ) received a single dose (0.1 mg/kg) of ZA; the Experimental Acid Zoledronic group (EAZ) received a single dose (0.1 mg/kg) one week prior to the start of tooth movement; and the Control Without movement group (CWM) that received no drug and without application of tooth movement...
September 2016: Brazilian Dental Journal
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