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https://www.readbyqxmd.com/read/28329679/mammalian-diaphanous-1-mediates-a-pathway-for-e-cadherin-to-stabilize-epithelial-barriers-through-junctional-contractility
#1
Bipul R Acharya, Selwin K Wu, Zi Zhao Lieu, Robert G Parton, Stephan W Grill, Alexander D Bershadsky, Guillermo A Gomez, Alpha S Yap
Formins are a diverse class of actin regulators that influence filament dynamics and organization. Several formins have been identified at epithelial adherens junctions, but their functional impact remains incompletely understood. Here, we tested the hypothesis that formins might affect epithelial interactions through junctional contractility. We focused on mDia1, which was recruited to the zonula adherens (ZA) of established Caco-2 monolayers in response to E-cadherin and RhoA. mDia1 was necessary for contractility at the ZA, measured by assays that include a FRET-based sensor that reports molecular-level tension across αE-catenin...
March 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/28327519/identification-of-quantitative-trait-loci-conditioning-the-main-biomass-yield-components-and-resistance-to-melampsora-spp-in-salix-viminalis-%C3%A3-salix-schwerinii-hybrids
#2
Paweł Sulima, Jerzy A Przyborowski, Anna Kuszewska, Dariusz Załuski, Małgorzata Jędryczka, Witold Irzykowski
The biomass of Salix viminalis is the most highly valued source of green energy, followed by S. schwerinii, S. dasyclados and other species. Significant variability in productivity and leaf rust resistance are noted both within and among willow species, which creates new opportunities for improving willow yield parameters through selection of desirable recombinants supported with molecular markers. The aim of this study was to identify quantitative trait loci (QTLs) linked with biomass yield-related traits and the resistance/susceptibility of Salix mapping population to leaf rust...
March 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28323142/zoledronic-acid-improves-bone-histomorphometry-in-a-murine-model-of-rett-syndrome
#3
Jay R Shapiro, Adele L Boskey, Stephen B Doty, Lyudmila Lukashova, Mary E Blue
Rett syndrome (RTT) is a neurodevelopmental disorder predominately affecting young females, caused by deficiency of the global transcriptional protein methyl CpG binding protein 2 (MeCP2). Osteoblasts express MeCP2 and girls with RTT experience early onset osteoporosis, decreased bone mass and an increased fracture risk. There is no defined treatment for osteoporosis associated with RTT. The present study evaluated the effects of zoledronic acid (ZA), a third generation nitrogen-containing bisphosphonate with primarily anti-osteoclastic activity, in a mouse model of MeCP2 deficiency...
March 16, 2017: Bone
https://www.readbyqxmd.com/read/28300506/adding-celecoxib-with-or-without-zoledronic-acid-for-hormone-na%C3%A3-ve-prostate-cancer-long-term-survival-results-from-an-adaptive-multiarm-multistage-platform-randomized-controlled-trial
#4
Malcolm D Mason, Noel W Clarke, Nicholas D James, David P Dearnaley, Melissa R Spears, Alastair W S Ritchie, Gerhardt Attard, William Cross, Rob J Jones, Christopher C Parker, J Martin Russell, George N Thalmann, Francesca Schiavone, Estelle Cassoly, David Matheson, Robin Millman, Cyrill A Rentsch, Jim Barber, Clare Gilson, Azman Ibrahim, John Logue, Anna Lydon, Ashok D Nikapota, Joe M O'Sullivan, Emilio Porfiri, Andrew Protheroe, Narayanan Nair Srihari, David Tsang, John Wagstaff, Jan Wallace, Catherine Walmsley, Mahesh K B Parmar, Matthew R Sydes
Purpose Systemic Therapy for Advanced or Metastatic Prostate Cancer: Evaluation of Drug Efficacy is a randomized controlled trial using a multiarm, multistage, platform design. It recruits men with high-risk, locally advanced or metastatic prostate cancer who were initiating long-term hormone therapy. We report survival data for two celecoxib (Cel)-containing comparisons, which stopped accrual early at interim analysis on the basis of failure-free survival. Patients and Methods Standard of care (SOC) was hormone therapy continuously (metastatic) or for ≥ 2 years (nonmetastatic); prostate (± pelvic node) radiotherapy was encouraged for men without metastases...
March 13, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28284745/prolonged-use-of-zoledronic-acid-4-years-did-not-improve-outcome-in-multiple-myeloma-patients
#5
Agustin Avilès, Maria-Jesùs Nambo, Judith Huerta-Guzmàn, Sergio Cleto, Natividad Neri
BACKGROUND: Bisphosphonates, especially zoledronic acid (ZA), show antitumor effects in multiple myeloma (MM) and other neoplasms. The standard time for ZA administration has been 2 years. However, with improvement in overall survival (OS) in MM with new agents, it unclear whether ZA could be administered for a prolonged time to improve OS. PATIENTS AND METHODS: A total of 170 patients with untreated, symptomatic MM were randomly divided into a group to receive ZA for 4 years, with a control group to receive ZA for 2 years...
February 16, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28281643/reactive-oxygen-species-are-required-for-zoledronic-acid-induced-apoptosis-in-osteoclast-precursors-and-mature-osteoclast-like-cells
#6
Ta-Wei Tai, Ching-Yu Chen, Fong-Chin Su, Yuan-Kun Tu, Tsung-Ting Tsai, Chiou-Feng Lin, I-Ming Jou
Inhibiting osteoclasts and osteoclast precursors to reduce bone resorption is an important strategy to treat osteoclast-related diseases, such as osteoporosis, inflammatory bone loss, and malignant bone metastasis. However, the mechanism by which apoptosis is induced in the osteoclasts and their precursors are not completely understood. Here, we used nitrogen-containing bisphosphonate zoledronic acid (ZA) to induce cell apoptosis in human and murine osteoclast precursors and mature osteoclast-like cells. Caspase-3-mediated cell apoptosis occurred following the ZA (100 μM) treatment...
March 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28262786/thermal-transport-and-anharmonic-phonons-in-strained-monolayer-hexagonal-boron-nitride
#7
Shasha Li, Yue Chen
Thermal transport and phonon-phonon coupling in monolayer hexagonal boron nitride (h-BN) under equibiaxial strains are investigated from first principles. Phonon spectra at elevated temperatures have been calculated from perturbation theory using the third-order anharmonic force constants. The stiffening of the out-of-plane transverse acoustic mode (ZA) near the Brillouin zone center and the increase of acoustic phonon lifetimes are found to contribute to the dramatic increase of thermal transport in strained h-BN...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28251171/analysis-of-myosin-ii-minifilament-orientation-at-epithelial-zonula-adherens
#8
Magdalene Michael, Xuan Liang, Guillermo A Gomez
Non-muscle myosin II (NMII) form bipolar filaments, which bind F-actin to exert cellular contractility during physiological processes (Vicente-Manzanares et al., 2009). Using a combinatorial approach to fluorescently label both N- and C-termini of the NMII heavy chain, recent works have demonstrated the ability to visualize NMII bipolar filaments at various subcellular localizations (Ebrahim et al., 2013; Beach et al., 2014). At the zonula adherens (ZA) of epithelia, NMII minifilaments bind the circumferential actin bundles in a pseudo-sarcomeric manner (Ebrahim et al...
December 5, 2016: Bio-protocol
https://www.readbyqxmd.com/read/28248151/p2x7-antagonists-for-cns-indications-recent-patent-disclosures
#9
REVIEW
Paolo Pevarello, Silvia Bovolenta, Paola Tarroni, Lorena Za, Elda Severi, Domenica Torino, Rocco Vitalone
P2X7, a ligand-gated purinergic ion channel, has been at the center of intense efforts in the pharmaceutical industry in the last 15 years due to the growing appreciation of its role in inflammation. Since 2008-2009, increased focus on CNS available compounds has led to the publication of various patents on behalf of several pharmaceutical companies. This patent review aims at analyzing the recent patent literature (2008-2016) with a particular emphasis on those patents that are thought to deal with CNS penetrant compounds on the basis of their physicochemical features, the assays described in the patents and the uses these compounds are claimed for...
March 2017: Pharmaceutical Patent Analyst
https://www.readbyqxmd.com/read/28240096/role-of-%C3%AE-2-microglobulin-in-postoperative-cognitive-decline
#10
Marta Załęska-Kocięcka, Paweł Jezierski, Maciej Grabowski, Krzysztof Kuśmierski, Maciej Dąbrowski, Katarzyna Piotrowska, Marek Banaszewski, Jacek Imiela, Janina Stępińska
AIM: β2-microglobulin (β2M) was proved to affect hippocampal functions in mice. MATERIALS & METHODS: Seventy-one patients undergoing aortic valve replacement were analyzed in prospective observational study. Kidney biomarkers and Mini Mental State Examinations (MMSEs) were performed before procedure, at discharge and after 6 months. RESULTS: Patients with β2M increase over the median change (>0.42 mg/l) experienced a significant in-hospital drop in MMSE (p = 0...
March 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28230589/effects-of-local-and-systemic-zoledronic-acid-application-on-titanium-implant-osseointegration-an-experimental-study-conducted-on-two-surface-types
#11
Serkan Dundar, Ferhan Yaman, Orhan Gecor, Omer Cakmak, Mustafa Kirtay, Tuba Talo Yildirim, Tahir Karaman, Mehmet Emre Benlidayi
The aim of this study was to evaluate the effects of local and systemic zoledronic acid (ZA) applications on titaniumoksit ceramic blasted (TiO-CB)- and sandblasted large acid-grit (SLA)-surfaced titanium implant osseointegration. Twelve New Zealand White rabbits were used in the study, divided into 6 groups: the TiO-CB (TiO-CB-CNT) (n = 2) and SLA (SLA-CNT) (n = 2) control groups in which TiO-CB- and SLA-surfaced titanium implants were surgically inserted into rabbit tibias but no treatment was applied; the TiO-CB (TiO-CB-LZA) (n = 2) and SLA (SLA-LZA) (n = 2) local ZA groups in which 1 mL of normal saline solution containing 2 mg of ZA was injected into sockets and after this the implants were integrated; and the TiO-CB (TiO-CB-SZA) (n = 2) and SLA (SLA-SZA) (n = 2) systemic ZA groups in which a single infusion of 0...
February 22, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28220258/impact-of-denosumab-use-on-the-survival-of-untreated-non-squamous-non-small-cell-lung-cancer-patients-with-bone-metastases
#12
Hibiki Udagawa, Seiji Niho, Keisuke Kirita, Shigeki Umemura, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto
PURPOSE: Denosumab reduces the incidence of skeletal-related events (SREs) in solid tumor patients with bone metastases (BM). However, there have been no detailed reports of the efficacy of denosumab in untreated non-squamous non-small cell lung cancer (NSCLC) patients with BM. METHODS: The medical records of patients with untreated non-squamous NSCLC and BM at diagnosis at our institution were reviewed retrospectively. The overall survival (OS) and the time to SREs were analyzed according to the treatment for the BM...
February 20, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28214773/the-usefulness-of-bone-biomarkers-for-monitoring-treatment-disease-a-comparative-study-in-osteolytic-and-osteosclerotic-bone-metastasis-models
#13
Marta Martín-Fernández, Karmele Valencia, Carolina Zandueta, Cristina Ormazábal, Susana Martínez-Canarias, Fernando Lecanda, Concepción de la Piedra
BACKGROUND: The skeleton is the most common site of colonization by metastatic cancers. Zoledronic acid (ZA) has been shown to be effective for the treatment of bone metastases regardless of whether the bone lesions are osteolytic or osteoblastic. Biochemical markers of bone turnover may be useful tools to quantify the degree of bone remodeling in the presence of bone metastases. The aim of this work was to establish the correlation between tumor dispersion (bioluminescence) and biochemical markers of bone turnover in two osteolytic and osteoblastic metastasis models in mice...
April 2017: Translational Oncology
https://www.readbyqxmd.com/read/28182104/phytoconstituents-and-nutritional-properties-of-the-fruits-of-eleutherococcus-divaricatus-and-eleutherococcus-sessiliflorus-a-study-of-non-european-species-cultivated-in-poland
#14
Daniel Załuski, Marta Olech, Robert Verpoorte, Inamullah Khan, Rafał Kuźniewski, Renata Nowak
Eleutherococcus fruits have been consumed in Russia and Asia throughout the centuries. Currently, there is an increasing interest in these products by the community of Western Europe. Many people suffer from micronutrient deficiencies, known as malnutrition, which consequently influences body condition. The aim of this study was to investigate pharmaconutrition, proximate, mineral, and fatty acid composition, total phenolics content, and total flavonoids content of Eleutherococcus divaricatus and Eleutherococcus sessiliflorus fruits cultivated in Poland...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28171719/nano-hydroxyapatite-bone-substitute-functionalized-with-bone-active-molecules-for-enhanced-cranial-bone-regeneration
#15
Arun Kumar Teotia, Deepak Bushan Raina, Chandan Singh, Neeraj Sinha, Hanna Isaksson, Magnus Tägil, Lars Lidgren, Ashok Kumar
The aim of this study was to synthesize and characterize a nano-hydroxyapatite (nHAP) and calcium sulfate bone substitute (NC) for cranioplasty. The NC was functionalized with low concentrations of bone morphogenetic protein-2 (BMP-2) and zoledronic acid (ZA) and characterized both in vitro and in vivo. In vitro studies included MTT, ALP assays, and fluorescent staining of Saos-2 (human osteoblasts) and MC3T3-E1 (murine preosteoblasts) cells cultured on NC. An in vivo study divided 20 male Wistar rats into four groups: control (defect only), NC, NC + ZA, and NC + ZA + rhBMP-2...
March 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28160593/dental-extraction-following-zoledronate-induces-osteonecrosis-in-rat-s-jaw
#16
X Vidal-Gutiérrez, J-F Gómez-Clavel, L-A Gaitán-Cepeda
BACKGROUND: Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ) is clinically characterized by the presence of exposed bone in the oral cavity that persists for more than eight weeks. Previous attempts to establish an animal model have not sufficiently considered disease features. Our aim was to establish an inexpensive and replicable animal model that develops BRONJ in a short time. MATERIAL AND METHODS: Thirty-two male Wistar rats were randomly divided into two groups: control and experimental...
March 1, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28157087/interface-thermal-conductance-of-van-der-waals-monolayers-on-amorphous-substrates
#17
Gabriela C Correa, Cameron J Foss, Zlatan Aksamija
Heterostructures based on atomic monolayers are emerging as leading materials for future energy efficient and multifunctional electronics. Due to the single atom thickness of monolayers, their properties are strongly affected by interactions with the external environment. We develop a model for interface thermal conductance (ITC) in an atomic monolayer van der Waals bonded to a disordered substrate. Graphene on SiO2 is initially used in our model and contrasted against available experimental data; the model is then applied to monolayer molybdenum disulfide (MoS2) on SiO2 substrate...
February 3, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28130238/the-jws-online-simulation-database
#18
Martin Peters, Johann J Eicher, David D van Niekerk, Dagmar Waltemath, Jacky L Snoep
JWS Online is a web-based platform for construction, simulation and exchange of models in standard formats. We have extended the platform with a database for curated simulation experiments that can be accessed directly via a URL, allowing one-click reproduction of published results. Users can modify the simulation experiments and export them in standard formats. The Simulation database thus lowers the bar on exploring computational models, helps users create valid simulation descriptions and improves the reproducibility of published simulation experiments...
January 27, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28120114/longitudinal-patterns-of-bone-targeted-agent-use-among-patients-with-solid-tumors-and-bone-metastases-in-the-united-states
#19
Yi Qian, Debajyoti Bhowmik, Nandita Kachru, Rohini K Hernandez
PURPOSE: This study examined real-world long-term use of guideline-recommended bone targeted agents (BTA) among patients with metastatic solid tumors. METHODS: Adults with a solid tumor diagnosis followed by a bone metastasis diagnosis in 2012-2014 were identified from electronic medical records in the Oncology Services Comprehensive Electronic Records (OSCER) database. Patients initiated zoledronic acid (ZA) or denosumab on or after the bone metastasis diagnosis and were followed through last clinic visit by 30 June 2015...
January 24, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28106454/search-for-invisible-decays-of-sub-gev-dark-photons-in-missing-energy-events-at-the-cern-sps
#20
D Banerjee, V Burtsev, D Cooke, P Crivelli, E Depero, A V Dermenev, S V Donskov, F Dubinin, R R Dusaev, S Emmenegger, A Fabich, V N Frolov, A Gardikiotis, S N Gninenko, M Hösgen, V A Kachanov, A E Karneyeu, B Ketzer, D V Kirpichnikov, M M Kirsanov, S G Kovalenko, V A Kramarenko, L V Kravchuk, N V Krasnikov, S V Kuleshov, V E Lyubovitskij, V Lysan, V A Matveev, Yu V Mikhailov, V V Myalkovskiy, V D Peshekhonov, D V Peshekhonov, O Petuhov, V A Polyakov, B Radics, A Rubbia, V D Samoylenko, V O Tikhomirov, D A Tlisov, A N Toropin, A Yu Trifonov, B Vasilishin, G Vasquez Arenas, P Ulloa, K Zhukov, K Zioutas
We report on a direct search for sub-GeV dark photons (A^{'}), which might be produced in the reaction e^{-}Z→e^{-}ZA^{'} via kinetic mixing with photons by 100 GeV electrons incident on an active target in the NA64 experiment at the CERN SPS. The dark photons would decay invisibly into dark matter particles resulting in events with large missing energy. No evidence for such decays was found with 2.75×10^{9} electrons on target. We set new limits on the γ-A^{'} mixing strength and exclude the invisible A^{'} with a mass ≲100  MeV as an explanation of the muon g_{μ}-2 anomaly...
January 6, 2017: Physical Review Letters
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