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https://www.readbyqxmd.com/read/28058588/the-hypoglycemic-hypolipidemic-and-anti-diabetic-nephritic-activities-of-zeaxanthin-in-diet-streptozotocin-induced-diabetic-sprague-dawley-rats
#1
Ling Kou, Mingzhao Du, Chaopu Zhang, Zhiyin Dai, Xuan Li, Baohai Zhang
Zeaxanthin (ZA), an important compound found in Lycium barbarum, shows various pharmacodynamic effects. In our present study, a high-fat, high-sucrose diet and streptozotocin (STZ)-induced diabetic rat model was used to investigate the antidiabetic activities of ZA. After a 4-week administration of 200 and 400 mg/kg of ZA and 100 mg/kg of metformin hydrochloride, various blood biochemical indexes were detected. ZA strongly normalized the reduced bodyweight and enhanced fasting blood glucose in diabetic rats...
January 5, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28035042/rock1-but-not-rock2-contributes-to-rhoa-signaling-and-nmiia-mediated-contractility-at-the-epithelial-zonula-adherens
#2
Rashmi Priya, Xuan Liang, Jessica L Teo, Kinga Duszyc, Alpha S Yap, Guillermo A Gomez
Rho kinases (ROCK1 and ROCK2) function downstream of the small GTPase RhoA to drive actomyosin cytoskeletal remodeling. It has often been believed that ROCK1 and ROCK2 may be functionally redundant, as they share a highly conserved kinase domain. However, in this study, we report differential functional effects for these ROCKs at the epithelial zonula adherens (ZA). Using specific siRNA, we found that ROCK1 depletion disrupted cadherin organization at the ZA, accompanied by loss of F-actin and NMIIA, whereas ROCK2 knockdown had no significant effect...
January 1, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28032187/using-telemedicine-to-teach-paediatric-surgery-in-resource-limited-countries
#3
REVIEW
Alp Numanoglu
Halstedian method of surgical training has been the mainstay of surgical education for many decades. Onsite knowledge sources in surgery have traditionally been textbooks, which are often a number of years out of date or teaching rounds with a Professor or senior colleague that enables a small number of trainees to benefit from. Congresses have been a good way of learning new developments in the field, but they often require travelling and are very costly. We have identified web-based education as a means of linking experts with trainees, regardless of their geographic location and often without requiring any substantial capital...
December 28, 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/28030936/association-of-anthropometric-measures-of-obesity-and-chronic-kidney-disease-in-elderly-women
#4
Andrzej Jaroszynski, Tadeusz Dereziński, Anna Jaroszyńska, Tomasz Zapolski, Beata Wąsikowska, Andrzej Wysokiński, Arkadiusz Jawień, Wojciech Załuska, Andrzej Horoch
INTRODUCTION AND OBJECTIVE: Growing evidence suggests that obesity is an important contributor to the development of chronic kidney disease (CKD). The relationship between obesity and CKD is complex and not completely understood, and the best anthropometric index of obesity in predicting CKD is controversial. This study aimed to determine the best anthropometric index of obesity in predicting CKD in a population of elderly women. MATERIALS AND METHODS: Anthropometric indexes of obesity including body mass index (BMI), waist circumference (WC), waist-to-height ratio (WheiR) and waist-to-hip-ratio (WHR), were obtained in 730 selected females...
23, 2016: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28029097/influence-of-silver-content-on-rifampicin-adsorptivity-for-magnetite-ag-rifampicin-nanoparticles
#5
Olena Ivashchenko, Emerson Coy, Barbara Peplinska, Marcin Jarek, Mikołaj Lewandowski, Karol Załęski, Alicja Warowicka, Anna Wozniak, Tatiana Babutina, Justyna Jurga-Stopa, Janez Dolinsek, Stefan Jurga
Magnetite nanoparticles (NPs) decorated with silver (magnetite/Ag) are intensively investigated due to their application in the biomedical field. We demonstrate that the increase of silver content on the surface of nanoparticles improves the adsorptivity of antibiotic rifampicin as well as antibacterial properties. The use of ginger extract allowed to improve the silver nucleation on the magnetite surface that resulted in an increase of silver content. Physicochemical and functional characterization of magnetite/Ag NPs was performed...
February 3, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28018444/compound-heterozygous-mutations-of-acads-gene-in-newborn-with-short-chain-acyl-coa-dehydrogenase-deficiency-case-report-and-literatures-review
#6
Se Jin An, Sook Za Kim, Gu Hwan Kim, Han Wook Yoo, Han Hyuk Lim
Short-chain acyl-CoA dehydrogenase deficiency (SCADD) is a rare autosomal recessive mitochondrial disorder of fatty acid β-oxidation, and is associated with mutations in the acyl-CoA dehydrogenase (ACADS) gene. Recent advances in spectrometric screening for inborn errors of metabolism have helped detect several metabolic disorders, including SCADD, without symptoms in the neonate period. This allows immediate initiation of treatment and monitoring, so they remain largely symptomless metabolic disease. Here, we report a 15-month-old asymptomatic male, who was diagnosed with SCADD by newborn screening...
November 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/28009034/fire-eater-s-lung
#7
Jolanta Załęska, Arkadiusz Błaszczyk, Lilia Jakubowska, Janusz Szopiński, Mateusz Polaczek, Jacek Grudny, Jacek Zych, Kazimierz Roszkowski-Śliż
Fire eater's lung (FEL) is an acute hydrocarbon pneumonitis caused by aspiration or inhalation into airways of liquid hydrocarbons. This disorder is classified into distinct form of chemical toxic pneumonitis. An amateur fire-eater is presented in this work. He accidentally aspirated into airways about 1/3 of glass of grill lighter fluid composed of mixture of liquid hydrocarbons. A few hours after this incident he had severe symptoms like weakness, high temperature, midsternal pleuritic chest pain, myalgia of the back, shortness of breath, and dry cough...
2016: Adv Respir Med
https://www.readbyqxmd.com/read/27997371/first-principles-study-of-thermal-transport-in-nitrogenated-holey-graphene
#8
Tao Ouyang, Huaping Xiao, Chao Tang, Xiaoliang Zhang, Ming Hu, Jianxin Zhong
Nitrogenated holey graphene (NHG), a new two-dimensional graphene variant with a large fundamental direct band gap, has recently been successfully synthesized via a simple wet-chemical reaction. Motivated by its unique geometry and novel properties, we investigated the phonon transport properties of the material by combining first-principle calculations and the phonon Boltzmann transport equation. The lattice thermal conductivity of NHG at room temperature is predicted to be about 82.22 W mK(-1), which is almost two orders of magnitude lower than that of graphene (about 3500 W mK(-1))...
January 27, 2017: Nanotechnology
https://www.readbyqxmd.com/read/27982227/effects-of-zoledronic-acid-on-orthodontic-tooth-movement-in-rats
#9
Marcel Durante Brunet, Cristiano Miranda de Araujo, Aline Cristina Batista Rodrigues Johann, Elisa Souza Camargo, Orlando Motohiro Tanaka, Odilon Guariza
The purpose of this study was to assess the effects of the administration of zoledronic acid (ZA) during orthodontic movement in rats. A hundred and twenty male Wistar rats were applied force of 30 cN with spring closed nickel-titanium to move the upper right first molar to mesial. In the Control Movement group (CM), only tooth movement was performed; the Control Acid Zoledronic group (CAZ) received a single dose (0.1 mg/kg) of ZA; the Experimental Acid Zoledronic group (EAZ) received a single dose (0.1 mg/kg) one week prior to the start of tooth movement; and the Control Without movement group (CWM) that received no drug and without application of tooth movement...
September 2016: Brazilian Dental Journal
https://www.readbyqxmd.com/read/27977859/immune-cell-profile-of-dental-pulp-tissue-treated-with-zoledronic-acid
#10
P G de Barros Silva, M E Q L Verde, L A C Brizeno, D V T Wong, R C P Lima Júnior, F B Sousa, M R L Mota, A P N N Alves
AIM: To characterize the pulp immune cell profile in the teeth of rats treated with zoledronic acid (ZA). METHODOLOGY: Male Wistar rats (n = 6 per group) received four intravenous infusions of ZA at doses of 0.04, 0.20 or 1.00 mg kg(-1) ZA or saline (control). On the 70th experimental day, they were euthanized. The first right molar was examined microscopically and submitted to toluidine blue reaction and immunohistochemical for CD68, tumour necrosis Factor (TNF)-α, interleukin (IL)-1β, inducible nitric oxide synthase (iNOS), nuclear factor kappa B (NF-kB) and IL-18 binding protein (IL-18 bp)...
December 15, 2016: International Endodontic Journal
https://www.readbyqxmd.com/read/27924611/quantitative-real-time-gene-profiling-of-human-alveolar-osteoblasts
#11
Dawn E Coates, Sobia Zafar, Trudy J Milne
The use of quantitative real-time reverse transcriptase PCR (qRT(2)-PCR) for the identification of differentially regulated genes is a powerful technology. The protocol presented here uses qRT(2)-PCR gene arrays to investigate the regulation of 84 angiogenic related genes in human primary alveolar osteoblasts following treatment with the bisphosphonate, zoledronic acid (ZA), and geranylgeraniol (GGOH). GGOH has potential as a therapeutic agent for Bisphosphate-Related Osteonecrosis of the Jaw (BRONJ), a serious side-effect resulting from the treatment for metastatic cancer (Zafar et al...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27919856/postoperative-day-one-serum-alanine-aminotransferase-does-not-predict-patient-morbidity-and-mortality-after-elective-liver-resection-in-non-cirrhotic-patients
#12
Ricky Harminder Bhogal, Amit Nair, Davide Papis, Zaed Hamady, Jawad Ahmad, For Tai Lam, Saboor Khan, Gabriele Marangoni
Serum aminotransferases have been used as surrogate markers for liver ischemia-reperfusion injury that follows liver surgery. Some studies have suggested that rises in serum alanine aminotransferase (ALT) correlate with patient outcome after liver resection. We assessed whether postoperative day 1 (POD 1) ALT could be used to predict patient morbidity and mortality following liver resection. We reviewed our prospectively held database and included consecutive adult patients undergoing elective liver resection in our institution between January 2013 and December 2014...
December 2016: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/27903800/genetic-variability-of-myxoma-virus-genomes
#13
Christoph Braun, Andrea Thürmer, Rolf Daniel, Anne-Kathrin Schultz, Ingo Bulla, Horst Schirrmeier, Dietmar Mayer, Andreas Neubert, Claus-Peter Czerny
: Myxomatosis is a recurrent problem on rabbit farms throughout Europe despite the success of vaccines. To identify gene variations of field and vaccine strains that may be responsible for changes in virulence, immunomodulation, and immunoprotection, the genomes of 6 Myxoma virus strains (MYXV) were sequenced: German field isolates Munich-1, FLI-H, 2604, 3207, vaccine strain MAV, and challenge strain ZA. The analyzed genomes ranged from 147.6 kb (strain MAV) to 161.8 kb (strain 3207) in size...
November 30, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27901204/response-of-a-co-culture-model-of-epithelial-cells-and-gingival-fibroblasts-to-zoledronic-acid
#14
Fernanda Gonçalves Basso, Diana Gabriela Soares, Taisa Nogueira Pansani, Ana Paula Silveira Turrioni, Débora Lopes Scheffel, Josimeri Hebling, Carlos Alberto de Souza Costa
Osteonecrosis of the jaw is an adverse effect of bisphosphonates. While the etiopathogenesis of this condition has been investigated, the interactions and effects of bisphosphonates on oral mucosa cells remain unclear. It is hypothesized that cell culture models, such as co-culture or three-dimensional cell culture models, can provide valuable insight. Therefore, the aim of this study was to evaluate the effects of zoledronic acid (ZA) on epithelial cells and gingival fibroblasts in a co-culture model. Briefly, epithelial cells were seeded on transwell inserts and gingival fibroblasts were seeded in the lower well of 24-well plates...
November 28, 2016: Brazilian Oral Research
https://www.readbyqxmd.com/read/27890546/radiological-evaluation-of-sphenozygomatic-suture-fixation-for-restoration-of-orbital-volume-a-retrospective-study
#15
Rohit Sharma, Chiyyarath Gopalan Muralidharan, Indranil Deb Roy, Narendra Kumar Jain, Seema Patrikar
PURPOSE: Lateral displacement of fracture zygomaticomaxillary complex (ZMC) can cause significant increase in orbital volume leading to enophthalmos. The aim of this study was to radiologically evaluate the efficacy of sphenozygomatic (SZ) suture fixation for restoration of orbital volume after elevation of the temporalis in cases of fracture ZMC where the fixation of zygomatic arch (ZA) was deemed necessary through latero-posterior approach. MATERIALS & METHODS: 43 operated cases of fracture ZMC using 4-point fixation were divided into two groups...
December 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/27887569/immune-modulation-of-cd4-cd25-regulatory-t-cells-by-zoledronic-acid
#16
Hsien Liu, Shih-Han Wang, Shin-Cheh Chen, Ching-Ying Chen, Jo-Lin Lo, Tsun-Mei Lin
BACKGROUND: CD4(+)CD25(+) regulatory T (Treg) cells suppress tumor immunity by inhibiting immune cells. Manipulation of Treg cells represents a new strategy for cancer treatment. Zoledronic acid (ZA), a nitrogen-containing bisphosphonate, inhibits the expression of receptor activator of nuclear factor kappa-B ligand (RANKL) on osteoblasts to inhibit osteoclastogenesis. In a mouse model of bisphosphonate-related osteonecrosis of the jaw, administration of ZA suppressed Treg-cell activity and activated inflammatory Th17 cells...
November 25, 2016: BMC Immunology
https://www.readbyqxmd.com/read/27856512/invasive-fungal-infections-in-chronic-lymphoproliferative-disorders-a-monocentric-retrospective-study
#17
Maria Chiara Tisi, Stefan Hohaus, Annarosa Cuccaro, Idanna Innocenti, Elena De Carolis, Tommaso Za, Francesco D' Alò, Luca Laurenti, Luana Fianchi, Simona Sica, Maurizio Sanguinetti, Valerio De Stefano, Livio Pagano
No abstract text is available yet for this article.
November 17, 2016: Haematologica
https://www.readbyqxmd.com/read/27855192/primo-an-interactive-homology-modeling-pipeline
#18
Rowan Hatherley, David K Brown, Michael Glenister, Özlem Tastan Bishop
The development of automated servers to predict the three-dimensional structure of proteins has seen much progress over the years. These servers make calculations simpler, but largely exclude users from the process. In this study, we present the PRotein Interactive MOdeling (PRIMO) pipeline for homology modeling of protein monomers. The pipeline eases the multi-step modeling process, and reduces the workload required by the user, while still allowing engagement from the user during every step. Default parameters are given for each step, which can either be modified or supplemented with additional external input...
2016: PloS One
https://www.readbyqxmd.com/read/27843753/bioinformatic-curation-and-alignment-of-genotyped-hepatitis-b-virus-hbv-sequence-data-from-the-genbank-public-database
#19
Trevor G Bell, Mukhlid Yousif, Anna Kramvis
BACKGROUND: Hepatitis B virus (HBV) DNA sequence data from thousands of samples are present in the public sequence databases. No publicly available, up-to-date, multiple sequence alignments, containing full-length and subgenomic fragments per genotype, are available. Such alignments are useful in many analysis applications, including data-mining and phylogenetic analyses. RESULTS: By issuing a query, all HBV sequence data from the GenBank public database was downloaded (67,893 sequences)...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27843534/phytochemical-content-and-pharma-nutrition-study-on-eleutherococcus-senticosus-fruits-intractum
#20
Daniel Załuski, Marta Olech, Agnieszka Galanty, Robert Verpoorte, Rafał Kuźniewski, Renata Nowak, Anna Bogucka-Kocka
In the past two decades public interest in herbal products has increased significantly in Europe, especially in the plant-based products from non-European traditions. Eleutherococcus senticosus has been used for the treatment of inflammatory diseases, anemia, and rheumatoid arthritis. The Eleutherococcus senticosus fruits intractum was examined for the content of phenolic acids (LC-ESI-MS/MS), minerals (AAS), TPC, and TFC (spectrophotometric assay). The antioxidant activity was determined using free radical scavenging assay and TLC-DB-DPPH(∗) dot-blot test...
2016: Oxidative Medicine and Cellular Longevity
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