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https://www.readbyqxmd.com/read/28815356/dent-disease-in-poland-what-we-have-learned-so-far
#1
Marcin Zaniew, Małgorzata Mizerska-Wasiak, Iga Załuska-Leśniewska, Piotr Adamczyk, Katarzyna Kiliś-Pstrusińska, Adam Haliński, Jan Zawadzki, Beata S Lipska-Ziętkiewicz, Krzysztof Pawlaczyk, Przemysław Sikora, Michael Ludwig, Maria Szczepańska
PURPOSE: Dent disease (DD) is a rare tubulopathy characterized by proximal tubular dysfunction leading to chronic kidney disease (CKD). The aim of the study was to characterize patients with DD in Poland. METHODS: A retrospective analysis of a national cohort with genetically confirmed diagnosis. RESULTS: Of 24 males, all patients except one carried mutations in the CLCN5 gene; in one patient a mutation in the OCRL gene was disclosed. Molecular diagnosis was delayed 1 year on average (range 0-21 years)...
August 16, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28812250/miv-150-and-zinc-acetate-combination-provides-potent-and-broad-activity-against-hiv-1
#2
Olga Mizenina, Mayla Hsu, Ninochka Jean-Pierre, Meropi Aravantinou, Keith Levendosky, Gabriela Paglini, Thomas M Zydowsky, Melissa Robbiani, José A Fernández-Romero
We previously showed that the combination of the non-nucleoside reverse transcriptase inhibitor (NNRTI) MIV-150 with zinc acetate (ZA) formulated in a carrageenan (CG; MZC) gel provided macaques significant protection against vaginal simian-human immunodeficiency virus-RT (SHIV-RT) challenge, better than either MIV-150/CG or ZA/CG. The MZC gel was shown to be safe in a phase 1 clinical trial. Herein, we used in vitro approaches to study the antiviral properties of ZA and the MIV-150/ZA combination, compared to other NNRTIs...
August 15, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28810653/surgical-trauma-and-low-dose-methylprednisolone-modulate-the-severity-of-the-acute-phase-response-induced-by-zoledronic-acid-infusion
#3
Jian Chen, Lipeng Yu, Lixin Chen, Xuan Wu, Pengyu Tang, Jian Yin, Tao Jiang, Guoyong Yin, Jin Fan
The aim of the present study was to investigate risk factors for the development of an acute-phase response (APR) associated with the initial zoledronic acid (ZA) infusion in patients undergoing surgery, and to assess whether its onset may be reduced by post-dose administration of low-dose methylprednisolone (MP) or acetaminophen. A retrospective study of patients with osteoporosis who attended the departments of orthopedics and endocrinology of a single hospital and received 5 mg ZA was conducted; the patients included surgical and non-surgical cases...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28802362/kallmann-syndrome-in-pediatric-otorhinolaryngology-practice-case-report-and-literature-review
#4
Karolina Dżaman, Karolina Zborowska-Piskadło, Mirosława Pietniczka-Załęska, Ireneusz Kantor
BACKGROUND: Kallmann syndrome (KS) is an isolated form of hypogonadotrophic hypogonadism (HH) in combination with a defect in olfactory function. The diagnosis of KS before maturation is often difficult to make due to the broad spectrum of presentation and genetic heterogeneities. ENT examination including smell test is essential for proper diagnosis of olfactory disturbances and non olfactory abnormalities in craniofacial region which may also be existent in KS. CASE: A 17-year-old girl admitted to ENT Department because of the olfactory sense disturbances since two years...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28802244/detoxification-of-diphenyl-ether-herbicide-lactofen-by-bacillus-sp-za-and-enantioselective-characteristics-of-an-esterase-gene-lace
#5
Jing Zhang, Luyao Lu, Feng Chen, Lingling Chen, Jingang Yin, Xing Huang
A bacterial strain Za capable of degrading diphenyl ether herbicide lactofen was isolated and identified as Bacillus sp. This strain could degrade 94.8% of 50mgL(-1) lactofen after 4days of inoculation in flasks. It was revealed that lactofen was initially hydrolyzed to desethyl lactofen, which was further transformed to acifluorfen, followed by the reduction of the nitro group to yield aminoacifluorfen. The phytotoxicity of the transformed product aminoacifluorfen to maize was decreased significantly compared with the lactofen...
August 3, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28798233/the-atad2-bromodomain-binds-different-acetylation-marks-on-the-histone-h4-in-similar-fuzzy-complexes
#6
Cassiano Langini, Amedeo Caflisch, Andreas Vitalis
Bromodomains are protein modules adopting conserved helix-bundle folds. Some bromodomain-containing proteins, such as ATPase family AAA domain-containing protein 2 (ATAD2), isoform A, have attracted much interest because they are overexpressed in many types of cancer. Bromodomains bind to acetylated lysine residues on histone tails and thereby facilitate the reading of the histone code. Epigenetic regulators in general have been implicated as indicators, mediators, or causes of a large number of diseases and disorders...
August 10, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28796280/effects-of-combined-teriparatide-and-zoledronic-acid-on-posterior-lumbar-vertebral-fusion-in-an-aged-ovariectomized-rat-model-of-osteopenia
#7
Mumingjiang Yishake, Miersalijiang Yasen, Libo Jiang, Wangmi Liu, Rong Xing, Qian Chen, Hong Lin, Jian Dong
There has been no study regarding the effect of a combination of teriparatide (TPTD) and zoledronic acid (ZA) on vertebral fusion. In this study, we investigate the effect of single and combined TPTD and ZA treatment on lumbar vertebral fusion in aged ovariectomized (OVX) rats. Sixty two-month-old female Sprague-Dawley rats were ovariectomized and underwent bilateral L4-5 posterolateral intertransverse fusion after ten months. The OVX rats received vehicle (control) treatment, or ZA (100µg/kg, once), or TPTD (60µg/kg/2 d for 42 d), or ZA + TPTD until they were euthanized at six weeks following lumbar vertebral fusion...
August 10, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28782662/elderly-patients-have-similar-short-term-outcomes-and-five-year-survival-compared-to-younger-patients-after-pancreaticoduodenectomy
#8
Awad Shamali, Henry D De'Ath, Bashar Jaber, Mahmoud Abuawad, Salvatore Barbaro, Zaed Hamaday, Mohammad Abu Hilal
BACKGROUND: Outcomes following pancreaticoduodenectomy (PD) in elderly patients in the United Kingdom (UK) remain uncertain. This study aimed to analyse peri-operative outcomes in the elderly, and investigate the impact of age on five-year survival following PD in a UK tertiary centre. MATERIALS AND METHODS: All patients who underwent PD in a single Hepatobiliary and Pancreatic unit in the UK between January 2007 to December 2015 were analysed from a prospectively collected database...
August 4, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28777600/lhc-as-an-axion-factory-probing-an-axion-explanation-for-g-2-_-%C3%AE-with-exotic-higgs-decays
#9
Martin Bauer, Matthias Neubert, Andrea Thamm
We argue that a large region of so-far unconstrained parameter space for axionlike particles (ALPs), where their couplings to the standard model are of order (0.01-1)  TeV^{-1}, can be explored by searches for the exotic Higgs decays h→Za and h→aa in run 2 of the LHC. Almost the complete region in which ALPs can explain the anomalous magnetic moment of the muon can be probed by searches for these decays with subsequent decay a→γγ, even if the relevant couplings are loop suppressed and the a→γγ branching ratio is less than 1...
July 21, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28767180/improved-union-and-bone-strength-in-a-mouse-model-of-nf1-pseudarthrosis-treated-with-recombinant-human-bone-morphogenetic-protein-2-and-zoledronic-acid
#10
Nikita Deo, Tegan L Cheng, Kathy Mikulec, Lauren Peacock, David G Little, Aaron Schindeler
Tibial pseudarthrosis associated with Neurofibromatosis type 1 (NF1) is an orthopedic condition with consistently poor clinical outcomes. Using a murine model that features localized double inactivation of the Nf1 gene in an experimental tibial fracture, we tested the effects of recombinant human bone morphogenetic protein-2 (rhBMP-2) and/or the bisphosphonate zoledronic acid (ZA). Tibiae were harvested at 3 weeks for analysis, at which time there was negligible healing in un-treated control fractures (7% union)...
August 2, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28756597/treatments-for-metastatic-prostate-cancer-mpc-a-review-of-costing-evidence
#11
REVIEW
Jan Norum, Carsten Nieder
BACKGROUND: Prostate cancer (PC) is the most common cancer in Western countries. More than one third of PC patients develop metastatic disease, and the 5-year expected survival in distant disease is about 35%. During the last few years, new treatments have been launched for metastatic castrate-resistant prostate cancer (mCRPC). OBJECTIVES: We aimed to review the current literature on health economic analysis on the treatment of metastatic prostate cancer (mPC), compare the studies, summarize the findings and make the results available to administrators and decision makers...
July 29, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28754539/in-vitro-genotoxicity-and-cytotoxicity-of-polydopamine-coated-magnetic-nanostructures
#12
Anna Woźniak, Magdalena Walawender, Dominika Tempka, Emerson Coy, Karol Załęski, Bartosz F Grześkowiak, Radosław Mrówczyński
Synthesis of magnetic nanoparticles and magnetic nanoclusters was performed by the co-precipitation method or solvothermal synthesis, respectively, followed by oxidative polymerization of dopamine, resulting in a polydopamine (PDA) shell. The nanomaterials obtained were described using TEM, FTIR and magnetic measurements. For the first time, cyto- and genotoxicity studies of polydopamine-coated nanostructures were performed on cancer and normal cell lines, providing in-depth insight into the toxicity of such materials...
July 25, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28743719/the-atypical-receptor-ccrl2-is-required-for-cxcr2-dependent-neutrophil-recruitment-and-tissue-damage
#13
Annalisa Del Prete, Laura Martínez-Muñoz, Cristina Mazzon, Lara Toffali, Francesca Sozio, Lorena Za, Daniela Bosisio, Luisa Gazzurelli, Valentina Salvi, Laura Tiberio, Chiara Liberati, Eugenio Scanziani, Annunciata Vecchi, Carlo Laudanna, Mario Mellado, Alberto Mantovani, Silvano Sozzani
CCRL2 is a seven transmembrane domain receptor that shares structural and functional similarities with the family of the Atypical Chemokine Receptors (ACKRs). CCRL2 is upregulated by inflammatory signals and, unlike from other ACKRs, is not a chemoattractant scavenging receptor, does not activate β-arrestins and is widely expressed by many leukocyte subsets. Therefore, the biological role of CCRL2 in immunity is still unclear. Here we report that CCRL2-deficient mice have a defect in neutrophil recruitment and are protected in two models of inflammatory arthritis...
July 25, 2017: Blood
https://www.readbyqxmd.com/read/28740535/acute-severe-diarrhoea-and-hyponatremia-after-zoledronic-acid-infusion-an-acute-phase-reaction
#14
Mohammad Shafi Kuchay, Khalid Jamal Farooqui, Ambrish Mithal
Zoledronic acid (ZA), an intravenous aminobisphosphonate, is prescribed widely for postmenopausal osteoporosis. It is a relatively safe drug but may cause adverse effects including acute phase reaction. Oral non-aminobisphosphonates are known to cause diarrhoea that is usually mild and self-limited. Intravenous amino-bisphosphonates are not known to cause diarrhoea. We describe a case of acute watery diarrhoea complicated by severe hyponatremia and hypotension following ZA infusion. The patient needed intensive care for four days...
January 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/28740523/the-effects-of-zoledronic-acid-on-ecg-a-prospective-study-on-patients-with-bone-metastatic-cancer
#15
Derya Demirtas, Cemil Bilir, Abdullah Orhan Demirtas, Huseyin Engin
INTRODUCTION: There are controversial results in the risk of atrial fibrillation as well as arrhythmogenic potential of bis-phosphonates. METHOD: 37 patients and 40 healthy controls were evaluated prospectively with regard to the cardiac side effects related to the use of zoledronic acid (ZA) and its effects on electrocardiography (ECG) parameters. RESULT: As the basal ECG results of the patients diagnosed with cancer compared with the control group, it was determined that QT maximum was significantly lower, QT minimum was significantly higher...
January 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/28725146/lc-esi-ms-ms-profiling-of-phenolics-from-eleutherococcus-spp-inflorescences-structure-activity-relationship-as-antioxidants-inhibitors-of-hyaluronidase-and-acetylcholinesterase
#16
Daniel Załuski, Marta Olech, Rafał Kuźniewski, Robert Verpoorte, Renata Nowak, Helena D Smolarz
Nature is a source of many plant-based molecules used as pro- or drugs. Eleutherococcus species are native to Asia and the North Russia, and are traditionally used to treat various diseases. In turn, neither secondary metabolites of the species cultivated in the West Europe nor the bioactivity is known. No differences in the phenols and flavonoids content in the inflorescences were found. The richest in polyphenols was E. giraldii (5.18 mg/g), while in flavonoids it was E. gracilistylus (1.80 mg/g). Using LC-ESI-MS/MS, protocatechuic and trans-caffeic acids have been identified as the most abundant compounds in E...
July 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28719100/deuteration-of-hyperpolarized-%C3%A2-%C3%A2-c-labelled-zymonic-acid-enables-sensitivity-enhanced-dynamic-mri-of-ph
#17
Christian Hundshammer, Stephan Düwel, Simone Köcher, Malte Gersch, Benedikt Feuerecker, Christoph Scheurer, Axel Haase, Steffen J Glaser, Markus Schwaiger, Franz Schilling
Aberrant pH is characteristic of many pathologies such as ischemia, inflammation or cancer. Therefore, a non-invasive and spatially resolved pH determination is valuable for disease diagnosis, characterization of response to treatment and the design of pH-sensitive drug delivery systems. We recently introduced hyperpolarized zymonic acid (ZA) as a novel MRI probe of extracellular pH utilizing dissolution dynamic polarization (DNP) for a more than 10,000-fold NMR signal enhancement. Here we present a strategy to enhance the sensitivity of this approach by deuteration of ZA (ZAd)...
July 18, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28708644/comparison-of-the-effects-of-local-and-systemic-zoledronic-acid-application-on-mandibular-distraction-osteogenesis
#18
Serkan Dundar, Gokhan Artas, Izzet Acikan, Ferhan Yaman, Mustafa Kirtay, Muhammed Fatih Ozupek, Fatih Asutay, Mustafa Kom
Bisphosphonates are antibone resorptive drugs that are used to prevent bone tissue resorption in several skeletal diseases. The aim of this study was to examine the effects of systemic and local applications of zoledronic acid (ZA) on newly regenerated bone in a model of experimental distraction osteogenesis (DO). To do this mandibular DO was applied to 30 adult female Sprague Dawley rats, which were randomly divided into 3 groups: control, DO only, systemic zoledronic acid (SZA), and local zoledronic acid (LZA)...
July 13, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28692257/targeting-osteocytes-to-attenuate-early-breast-cancer-bone-metastasis-by-theranostic-upconversion-nanoparticles-with-responsive-plumbagin-release
#19
Han Qiao, Zhaowen Cui, Shengbing Yang, Dingkun Ji, Yugang Wang, Ying Yang, Xiuguo Han, Qiming Fan, An Qin, Tingyu Wang, Xiao-Peng He, Wenbo Bu, Tingting Tang
The early detection and thus treatment of breast cancer bone metastasis remain a big challenge clinically. As the most abundant cells within bone tissue, osteocytes have been found to manipulate the activity of early cancer bone metastasis by its crosstalk with cancer cells and osteoclasts. However, conventional bone-targeting nanomedicine has limited bone-lesion specificity and ignores the vital role of osteocytes during breast cancer bone metastasis. Also, it lacks detailed insight into the therapeutic mechanisms, which hinders the following translational practice...
July 25, 2017: ACS Nano
https://www.readbyqxmd.com/read/28688093/influence-of-bisphosphonates-on-the-adherence-and-metabolism-of-epithelial-cells-and-gingival-fibroblasts-to-titanium-surfaces
#20
Fernanda Gonçalves Basso, Taisa N Pansani, Diana G Soares, Lais M Cardoso, Josimeri Hebling, Carlos Alberto de Souza Costa
OBJECTIVES: To evaluate the effects of sodium alendronate (SA) and zoledronic acid (ZA), on the adhesion and metabolism of epithelial cells and gingival fibroblasts to titanium surfaces considering cell functions related to an effective mucosal barrier around the implant. MATERIALS AND METHODS: Cells were seeded onto titanium discs and incubated for 24 h. Then, serum-free DMEM containing selected bisphosphonates (0, 0.5, 1, or 5 μM) was added for 24 and 48 h...
July 8, 2017: Clinical Oral Investigations
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