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https://www.readbyqxmd.com/read/29123990/the-skeletal-related-events-of-denosumab-versus-zoledronic-acid-in-patients-with-bone-metastases-a-meta-analysis-of-randomized-controlled-trials
#1
Zhicai Zhang, Feifei Pu, Zengwu Shao
Objective: The meta-analysis was used to evaluate the skeletal-related events (SREs) and efficacy of denosumab versus zoledronic acid (ZA) in patients with bone metastases. Methods: The data of this meta-analysis study were searched from PUBMED, EMBASE, Cochrane Library, Web of Science with Conference Proceedings, Elsevier and China National Knowledge Infrastructure (CNKI) databases till August 2017. Two independent reviewers reviewed the reference lists of relevant articles...
November 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29109954/role-of-periapical-diseases-in-medication-related-osteonecrosis-of-the-jaws
#2
Nian Jing Rao, Jing Yi Wang, Ru Qing Yu, Yiu Yan Leung, Li Wu Zheng
Objective: The present study aimed to investigate the role of periapical diseases in inducing medication-related osteonecrosis of the jaws (MRONJ) using an ovariectomized (OVX) mice model. Materials and Methods: Twenty C57BL/6N female mice were randomly assigned to two groups. All mice were subjected to bilateral ovariectomy and then treated with oncologic dose of zoledronic acid (ZA) or vehicle for twelve weeks. Eight weeks after commence of drug administration, a pulpal exposure (PE) operation was performed on the first right lower molar to induce periapical periodontitis; the contralateral non-PE tooth was used as control...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29101354/on-the-observability-of-pauli-crystals-in-experiments-with-ultracold-trapped-fermi-gases
#3
Debraj Rakshit, Jan Mostowski, Tomasz Sowiński, Magdalena Załuska-Kotur, Mariusz Gajda
The best known manifestation of the Fermi-Dirac statistics is the Pauli exclusion principle: no two identical fermions can occupy the same one-particle state. This principle enforces high-order correlations in systems of many identical fermions and is responsible for a particular geometric arrangement of trapped particles even when all mutual interactions are absent. These geometric structures, called Pauli crystals, are predicted for a system of N identical atoms trapped in a harmonic potential. They emerge as the most frequent configurations in a collection of single-shot pictures of the system...
November 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29100539/genome-wide-analysis-of-the-cellulose-synthase-like-csl-gene-family-in-bread-wheat-triticum-aestivum-l
#4
Simerjeet Kaur, Kanwarpal S Dhugga, Robin Beech, Jaswinder Singh
BACKGROUND: Hemicelluloses are a diverse group of complex, non-cellulosic polysaccharides, which constitute approximately one-third of the plant cell wall and find use as dietary fibres, food additives and raw materials for biofuels. Genes involved in hemicellulose synthesis have not been extensively studied in small grain cereals. RESULTS: In efforts to isolate the sequences for the cellulose synthase-like (Csl) gene family from wheat, we identified 108 genes (hereafter referred to as TaCsl)...
November 3, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29079514/dual-modulation-of-bone-formation-and-resorption-with-zoledronic-acid-loaded-biodegradable-magnesium-alloy-implants-improves-osteoporotic-fracture-healing-an-in-vitro-and-in-vivo-study
#5
Guoyuan Li, Lei Zhang, Lei Wang, Guangyin Yuan, Kerong Dai, Jia Pei, Yongqiang Hao
Osteoporotic fracture (OPF) remains a major clinical challenge for skeletal regeneration. Impaired osteogenesis and excessive remodeling result in prolonged and poor quality of fracture healing. To augment bone formation and inhibit excessive resorption simultaneously, we constructed a biodegradable magnesium-based implant integrated with the anti-catabolic drug zoledronic acid (ZA); this implant exhibits controllable, sustained release of magnesium degradation products and ZA in vitro. The extracts greatly stimulate the osteogenic differentiation of rat-bone marrow-derived mesenchymal stem cells (rBMSCs), while osteoclastogenesis is inhibited by ZA...
October 24, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29077715/protein-dynamics-and-structural-waters-in-bromodomains
#6
Xiaoxiao Zhang, Kai Chen, Yun-Dong Wu, Olaf Wiest
Bromodomains are epigenetic readers of acetylated lysines that are integral parts of histone tails. The 61 bromodomains in humans are structurally highly conserved but specifically bind to widely varying recognition motifs, suggesting that dynamic rather than static factors are responsible for recognition selectivity. To test this hypothesis, the dynamics of the binding sites and structural water molecules of four bromodomains (ATAD2, BAZ2B, BRD2(1) and CREBBP) representing four different subtypes is studied with 1 μs MD simulations using the RSFF2 force field...
2017: PloS One
https://www.readbyqxmd.com/read/29063388/utilization-of-agents-to-prevent-skeletal-related-events-among-patients-with-multiple-myeloma-analysis-of-real-world-data
#7
Yi Qian, Debajyoti Bhowmik, Nandita Kachru, Rohini K Hernandez, Paul Cheng, Alexander Liede
PURPOSE: This study examined real-world utilization patterns of bone-targeted agents (BTA) in patients with multiple myeloma (MM). METHODS: In this retrospective cohort study, adults with an MM diagnosis recorded in 2012-2014 were identified from electronic health records in the Oncology Services Comprehensive Electronic Records (OSCER) database. Patients received zoledronic acid (ZA) or pamidronate (PA) on/after first MM diagnosis recorded in the study period, had no BTA use in prior 6 months, and were followed through earliest of May 31, 2015 or last clinic visit...
October 23, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29043461/effect-of-anti-angiogenesis-induced-by-chemotherapeutic-monotherapy-chemotherapeutic-bisphosphonate-combination-therapy-and-anti-vegfa-mab-therapy-on-tooth-extraction-socket-healing-in-mice
#8
Yuri Akita, Shinichiro Kuroshima, Kazunori Nakajima, Hiroki Hayano, Riho Kanai, Muneteru Sasaki, Takashi Sawase
Osteonecrosis of the jaw (ONJ), which is a rare but severe adverse effect, mainly occurs in oncology patients receiving chemotherapeutic agents and bisphosphonates. However, the combined impact of chemotherapy and bisphosphonates on wound healing after tooth extraction remains unknown. The aim of this study was to determine the precise etiology of ONJ induced by chemotherapy and bisphosphonate combination therapy. Mice received zoledronate (ZA) monotherapy, cyclophosphamide (CY) monotherapy or CY/ZA combination therapy...
October 17, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29029608/association-of-trace-metal-elements-with-lipid-profiles-in-type-2-diabetes-mellitus-patients-a-cross-sectional-study
#9
Amare Desalegn Wolide, Belay Zawdie, Tilahun Alemayehu, Samuel Tadesse
BACKGROUND: It is well known that dyslipidemia and chronic hyperglycemia increase the onset of diabetes and diabetic complication. The aim of this study is to see the association of trace metals elements and lipid profile among type 2 diabetes mellitus patients. METHODS: The study was conducted on 214 type 2 diabetic patients at Jimma University Specialized Hospital, Jimma, Ethiopia. All the eligible study participants responded to the structured interviewer administered questionnaire and fasting venous blood was drawn for biochemical analysis...
October 13, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29025975/recognition-of-hyperacetylated-n-terminus-of-h2az-by-tbbdf2-from-trypanosoma-brucei
#10
Xiao Yang, Xuelei Wu, Jiahai Zhang, Xuecheng Zhang, Chao Xu, Shanhui Liao, Xiaoming Tu
Histone modification plays an important role in various biological processes, including gene expression regulation. Bromodomain, as one of histone readers, recognizes specifically the ε-N-lysine acetylation (KAc) of histone. Although the bromodomains and histone acetylation sites of Trypanosoma brucei ( T. brucei ), a lethal parasite responsible for sleeping sickness in human and nagana in cattle, have been identified, how acetylated histones are recognized by bromodomains is still unknown. Here, the bromodomain factor 2 (TbBDF2) from T...
October 12, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/29023215/cost-effectiveness-analysis-of-monthly-zoledronic-acid-zoledronic-acid-every-3-months-and-monthly-denosumab-in-women-with-breast-cancer-and-skeletal-metastases-calgb-70604-alliance
#11
Charles L Shapiro, James P Moriarty, Stacie Dusetzina, Andrew L Himelstein, Jared C Foster, Stephen S Grubbs, Paul J Novotny, Bijan J Borah
Purpose Skeletal-related events (SREs) such as pathologic fracture, spinal cord compression, or the necessity for radiation or surgery to bone metastasis cause considerable morbidity, decrements in quality of life, and costs to the health care system. The results of a recent large randomized trial (Cancer and Leukemia Group B/Alliance for Clinical Trials in Oncology [CALGB/Alliance 70604]) showed that zoledronic acid (ZA) every 3 months was noninferior to monthly ZA in reducing the risks of SREs. We sought to determine the cost-effectiveness (CE) of monthly ZA, ZA every 3 months, and monthly denosumab in women with breast cancer and skeletal metastases...
October 12, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28984092/patterns-of-changes-in-functional-and-neurocognitive-status-in-elderly-patients-after-transcatheter-vs-surgical-aortic-valve-replacements
#12
Marta Załęska-Kocięcka, Anna Skrobisz, Sebastian Woźniak, Lidia Greszata, Maciej Dąbrowski, Maciej Grabowski, Katarzyna Piotrowska, Anna Konopka, Marek Banaszewski, Anna Mierzynska
BACKGROUND: Replacement of severely stenotic aortic valve may influence cognitive and physical functioning. The aim of this study was to compare cognitive and functional status after surgical (SAVR) vs transcatheter aortic valve replacements (TAVR) in the elderly with severe aortic stenosis (AS). METHODS: It was a prospective observational study with over 6 months of follow-up. Eighty ≥70-year-old patients with AS underwent TAVR (n=40) or SAVR (n=40). Mini Mental State Exam (MMSE), Activities Daily Living (ADL) score and Instrumental Activities Daily Living (IADL) score were used to assess the cognitive status, fundamental functioning and complex independent living skills, respectively...
October 4, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28968872/pyscestoolbox-a-collection-of-metabolic-pathway-analysis-tools
#13
Carl D Christensen, Jan-Hendrik S Hofmeyr, Johann M Rohwer
Summary: PySCeSToolbox is an extension to the Python Simulator for Cellular Systems (PySCeS) that includes tools for performing generalised supply-demand analysis, symbolic metabolic control analysis, and a framework for investigating the kinetic and thermodynamic aspects of enzyme-catalysed reactions. Each tool addresses a different aspect of metabolic behaviour, control, and regulation; the tools complement each other and can be used in conjunction to better understand higher-level system behaviour...
September 14, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28967693/huma-a-platform-for-the-analysis-of-genetic-variation-in-humans
#14
David K Brown, Özlem Tastan Bishop
The completion of the human genome project at the beginning of the 21st century, along with the rapid advancement of sequencing technologies thereafter, has resulted in exponential growth of biological data. In genetics, this has given rise to numerous variation databases, created to store and annotate the ever-expanding dataset of known mutations. Usually, these databases focus on variation at the sequence level. Few databases focus on the analysis of variation at the 3D level, that is, mapping, visualizing, and determining the effects of variation in protein structures...
October 2, 2017: Human Mutation
https://www.readbyqxmd.com/read/28958784/long-term-therapy-with-intravenous-zoledronate-increases-the-number-of-nonattached-osteoclasts
#15
Maria José H Nagata, Michel R Messora, Cristina Antoniali, Stephen E Fucini, Natália de Campos, Natália M Pola, Carolina S Santinoni, Flávia A C Furlaneto, Edilson Ervolino
The purpose of this study was to investigate the influence of long-term therapy with intravenous zoledronate (ZA) on the healing of extraction sockets in rats. Forty rats, divided into groups C (Control) and Z (Zoledronate), received intravenous injections of either saline solution or ZA for 24 weeks. Their right maxillary incisor was extracted. Euthanasia was performed at 7 or 28 days postoperative. Histomorphometric (Newly Formed Bone Area) and immunohistochemical (RANKL, OPG and TRAP) analyses were performed...
August 19, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28957497/a-multi-scenario-genome-wide-medical-population-genetics-simulation-framework
#16
Jacquiline W Mugo, Ephifania Geza, Joel Defo, Samar S M Elsheikh, Gaston K Mazandu, Nicola J Mulder, Emile R Chimusa
Motivation: Recent technological advances in high-throughput sequencing and genotyping have facilitated an improved understanding of genomic structure and disease-associated genetic factors. In this context, simulation models can play a critical role in revealing various evolutionary and demographic effects on genomic variation, enabling researchers to assess existing and design novel analytical approaches. Although various simulation frameworks have been suggested, they do not account for natural selection in admixture processes...
October 1, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28954199/zoledronate-impairs-socket-healing-after-extraction-of-teeth-with-experimental-periodontitis
#17
A Soundia, D Hadaya, N Esfandi, I Gkouveris, R Christensen, S M Dry, O Bezouglaia, F Pirih, N Nikitakis, T Aghaloo, S Tetradis
Osteonecrosis of the jaws (ONJ) is a rare but severe complication of antiresorptive medications, such as bisphosphonates, used in the treatment of bone malignancy or osteoporosis. Tooth extraction and dental disease have been strongly associated with ONJ development. Here, we investigated molecular and cellular markers of socket healing after extraction of healthy or teeth with experimental periodontitis (EP) in Wistar-Han rats treated with zoledronic acid (ZA). We included 4 experimental groups: vehicle-treated animals with extraction of healthy teeth or teeth with ligature-induced EP and ZA-treated animals with extraction of healthy teeth or teeth with EP...
September 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28952190/il-12-and-il-15-induce-the-expression-of-cxcr6-and-cd49a-on-peripheral-natural-killer-cells
#18
Theresa Hydes, Angela Noll, Gabriela Salinas-Riester, Mohammed Abuhilal, Thomas Armstrong, Zaed Hamady, John Primrose, Arjun Takhar, Lutz Walter, Salim I Khakoo
INTRODUCTION: Murine hepatic NK cells exhibit adaptive features, with liver-specific adhesion molecules CXCR6 and CD49a acting as surface markers. METHODS: We investigated human liver-resident CXCR6+ and CD49a+ NK cells using RNA sequencing, flow cytometry, and functional analysis. We further assessed the role of cytokines in generating NK cells with these phenotypes from the peripheral blood. RESULTS: Hepatic CD49a+ NK cells could be induced using cytokines and produce high quantities of IFNγ and TNFα, in contrast to hepatic CXCR6+ NK cells...
September 27, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28951771/uplc-ms-ms-profile-of-alkaloids-with-cytotoxic-properties-of-selected-medicinal-plants-of-the-berberidaceae-and-papaveraceae-families
#19
Anna Och, Katarzyna Szewczyk, Łukasz Pecio, Anna Stochmal, Daniel Załuski, Anna Bogucka-Kocka
Cancer is one of the most occurring diseases in developed and developing countries. Plant-based compounds are still researched for their anticancer activity and for their quantity in plants. Therefore, the modern chromatographic methods are applied to quantify them in plants, for example, UPLC-MS/MS (ultraperformance liquid chromatography tandem mass spectrometry). Therefore, the aim of the present study was to evaluate the content of sanguinarine, berberine, protopine, and chelidonine in Dicentra spectabilis (L...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28949837/ecotoxicological-risk-assessment-of-chosen-pharmaceuticals-detected-in-surface-waters
#20
Monika Załęska-Radziwiłł, Katarzyna Affek, Nina Doskocz
The goal of this work was to assess the risk posed by the presence of ciprofloxacin, 17α-ethinylestradiol and 5-fluorouracil in aquatic ecosystems based on chronic single-species ecotoxicological tests. There were 23 species used in this study: one cyanobacterium, three green algae, one higher plant, one protozoan, two crustaceans, two fish, 12 bacteria and one fungus (yeast). The risk assessment was performed on the basis of the PEC/PNEC ratio (PEC - predicted environmental concentration, PNEC - predicted no-effect concentration)...
November 10, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
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