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Bullous dermatosis

Claudia Reynoso-von Drateln, Noemí Gómez-Hernández, Norma Rodríguez-Martínez, Carlos Torres-Lozano
An 81-year-old male and a 47-year-old female experienced recurrent severe bullous dermatosis secondary to an intake of drugs and alternative medicines indicated for arthralgias. The first patient had previously presented with Stevens-Johnson/toxic epidermal necrolysis (TEN) overlap syndrome in 2007 secondary to ingestion of trimethoprim/sulfamethoxazole indicated for a urinary tract infection; 6 years later, he presented with the same syndrome 2 days after ingestion of oral naproxen tablets 250 mg twice daily...
December 2016: Drug Saf Case Rep
Ho-June Lee, Sook Jung Yun, Seung-Chul Lee, Jee-Bum Lee
No abstract text is available yet for this article.
October 2016: Annals of Dermatology
S Goetze, A K Dumke, D Zillikens, U C Hipler, P Elsner
Anti-laminin γ1-pemphigoid (formerly known as anti-p200 pemphigoid) is a rare subepidermal autoimmunobullous disorder first described by Zillikens et al. in 1996 (1,2). Clinically, it mimics bullous pemphigoid, linear IgA dermatosis, dermatitis herpetiformis, pompholyx or the inflammatory variant of epidermolysis bullosa acquisita, respectively (1,3). The laminin γ1-chain has been identified as the major targeting antigen (1,4,5). Histologically, a subepidermal split is seen accompanied by neutrophils and eosinophils as well as linear deposits of IgG and/or C3 along the dermoepidermal junction in direct immunofluorescence microscopy (1)...
September 29, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Zaw Min, Raquel R Garcia, Monika Murillo, Jeffrey M Uchin, Nitin Bhanot
Intravenous vancomycin is a widely used antibiotics, but it causes different types of cutaneous hypersensitivity reactions, ranging from maculopapular rash, red-man syndrome, drug rash with eosinophilia and systemic symptoms, IgA bullous dermatosis, leukocytoclastic vasculitis, Stevens-Johnsons syndrome, to IgE-mediated anaphylaxis. We report an elderly patient with the end-stage renal disease presented with diffuse palpable purpura while receiving IV vancomycin therapy for methicillin-resistant Staphylococcus aureus septicemia...
September 25, 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
H Zaouri, H Amarouch, N Elmakrini, N Tazi, N Ismaili, L Benzekri, K Senouci, B Hassam
Mastocytosis is a group of diseases related to abnormal accumulation and proliferation of mast cells in one or more organs. They may be associated with an acquired point mutation and the activation of the receptor tyrosine-kinase c-KIT of CFS (mast cell growth factor). The clinical manifestations are varied and secondary to the release of mast cell mediators and/or infiltration of various organs. There are two main types of mastocytosis: pure cutaneous mastocytosis and systemic mastocytosis when more than two organs are involved in mast cell infiltration (bone marrow, gastrointestinal tract, bone, liver and spleen, lymph nodes)...
September 23, 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Ana Gameiro, Miguel Gouveia, Oscar Tellechea, Margarida Goncalo
UNLABELLED: Linear IgA bullous dermatosis (LABD) is a rare autoimmune blistering disease. LABD is considered mostly idiopathic, butsome cases have been reported to be drug-induced, mainly associated with vancomycin (VCM).We present two cases of LABD possibly associated with VCM used for cardiac surgery prophylaxis; in the presented cases, the eruptions occurred only after VCM withdrawal, therefore leaving a question about the relationship between VCM and LABD in these cases.We reviewed previous reports of VCM-induced LABD and analyzed the following parameters: gender, age, recent medical history, concurrent medication, latency period, progression after withdrawal, time to resolution, treatment, and rechallenge...
2016: Dermatology Online Journal
M Tourte, F Brunet-Possenti, S Mignot, L Gavard, V Descamps
Pemphigoid gestationis (PG) is a rare bullous dermatosis of pregnancy related to anti-BP180 circulating antibodies(1) which can be associated with obstetrical complications due to placental antibody transfer(2) . The management of skin lesions is based on topical steroids but in refractory cases oral steroids or immunosuppressive agents can be used(3) . To date there are no recommendations concerning the prevention of PG recurrence. We report herein the first successful preventive treatment of PG with rituximab...
September 8, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Euzeli da Silva Brandão, Iraci Dos Santos, Regina Serrão Lanzillotti, Adriano Menis Ferreira, Mônica Antar Gamba, Luna Azulay-Abulafia
OBJECTIVE: identify nursing diagnoses in patients with immune-bullous dermatosis. METHOD: a quantitative and descriptive research, carried out in three institutions located in Rio de Janeiro and Mato Grosso do Sul, Brazil, using the Client Assessment Protocol in Dermatology during a nursing consultation. Simple descriptive statistics was used for data analysis. RESULTS: 14 subjects participated in the study, nine with a diagnosis of pemphigus vulgaris, pemphigus two and three of bullous pemphigoid...
2016: Revista Latino-americana de Enfermagem
Zhipeng Zhang, Maosong Zhou, Jin Guo, Tiecheng Feng, Xinying Li, Huan Chen, Jindong Li
Paraneoplastic pemphigus is a rare autoimmune bullous dermatosis, which is caused by potential neoplasm, especially the Castleman's disease. Castleman's disease associated with paraneoplastic pemphigus is misdiagnosed frequently and easily in clinical practices. Furthermore, it is reported that the mortality rate for this disease is very high. Bronchiolitis obliterans is the most common complication and the most important cause of death. There was a female patient presenting recalcitrant mucocutaneous erosions, ulcers and scattered erythemas in the body...
May 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Keigo Koda, Yasunori Enomoto, Minako Omae, Daisuke Akahori, Takefumi Abe, Hirotsugu Hasegawa, Takashi Matsui, Koshi Yokomura, Takafumi Suda
An 86-year-old woman with severe dementia had been treated with oral prednisolone at 2 mg/day for autoimmune bullous dermatosis for several years. One year ago, she referred to our hospital due to an ulcerative skin lesion over the right tibial tuberosity. The lesion was treated by an iodine-containing ointment, but did not heal. Subsequently, a new skin lesion appeared in the right popliteal fossa. One month ago, the patient had increased sputum production that was accompanied by fever, anorexia, and dyspnea; consequently, she visited our department...
February 2016: Kekkaku: [Tuberculosis]
T Hashimoto, K Teye, N Ishii
OBJECTIVES: From our cohort of 5402 autoimmune bullous disease cases, we selected 49 cases with various types of intercellular IgA dermatosis (IAD) and 13 cases of classical subcorneal pustular dermatosis (SPD), for which sera and information were sent from other institutes in Japan and other countries. METHODS: We studied clinically and immunologically the 49 IAD cases and the 13 classical SPD cases. RESULTS: There were 17 SPD-type IAD, 12 intraepidermal neutrophilic IgA dermatosis (IEN)-type IAD, two IgA-pemphigus vegetans, 4 IgA-pemphigus foliaceus, 6 IgA-pemphigus vulgaris and 8 unclassified IAD cases...
June 3, 2016: British Journal of Dermatology
Annie Ferguson, Spring Golden
No abstract text is available yet for this article.
March 2016: JAAD Case Reports
Jasmit S Minhas, Paige G Wickner, Aidan A Long, Aleena Banerji, Kimberly G Blumenthal
BACKGROUND: Vancomycin is a broad-spectrum antibiotic whose use may be limited by adverse drug reactions (ADRs). Although vancomycin toxic effects are known, there are limited data on vancomycin hypersensitivity reactions (HSRs). OBJECTIVE: To understand the most commonly reported vancomycin HSRs through systematic case review. METHODS: We performed a literature search for English-language case reports and series from 1982 through 2015 (last search July 31, 2015) on Ovid MEDLINE and PubMed...
June 2016: Annals of Allergy, Asthma & Immunology
Cathy Y Zhao, Yi Zhen Chiang, Dedee F Murrell
We aimed to better understand the pathogenesis, clinical features, prognosis, and treatment of neonatal autoimmune blistering diseases (AIBDs). We searched Medline, Embase, PubMed, Latin American and Caribbean Health Sciences Literature, and reference lists of identified articles. Inclusion criteria were articles published from 1946 to December 2014 in any language. Exclusion criteria were age greater than 4 weeks and no confirmed AIBD diagnosis. We identified 51 cases of neonatal AIBDs: 34 cases of pemphigus (31 pemphigus vulgaris [PV], 3 pemphigus foliaceus [PF]) and 17 cases of pemphigoid diseases (9 bullous pemphigoid [BP], 5 linear immunoglobulin A bullous dermatosis [LABD], 1 BP and LABD, 1 epidermolysis bullosa acquisita, 1 bullous systemic lupus erythematosus)...
July 2016: Pediatric Dermatology
Jeffrey B Tiger, Jessica T Rush, Dorothea T Barton, Alexey V Danilov, M Shane Chapman
No abstract text is available yet for this article.
November 2015: JAAD Case Reports
Yi-Xiu Bai, Jin-Gang Chu, Ting Xiao, Hong-Duo Chen
Autoimmune bullous diseases (AIBDs)-associated interstitial lung disease (ILD) is extremely rare. Pemphigus vulgaris (PV) is an intraepidermal autoimmune blistering disease caused by circulating autoantibodies against desmoglein. To date, PV-associated ILD has rarely been reported in English literature. We report a rare association of PV and ILD. A 53-year-old Chinese female with PV for 8 months developed ILD after a relapse of PV for 2 months due to discontinuation of oral prednisone by herself. She was successfully treated by systemic methylprednisolone...
July 2016: Dermatologic Therapy
L Kissi, I Benyahy
Oral Lichen Planus (OLP) is a chronic inflammatory dermatosis usually benign that can affect skin, integuments and mucosal membranes. It is characterized by a disorder of keratinization and the polymorphism of clinical disease. Some of them correspond to a very intense lichen activity as erythematous, erosive and bullous forms, others concern mostly old forms of lichen planus as atrophic or hyperkeratotic and hypertrophic verrucous forms. In most of the cases, the OLP has a benign evolution but malignant transformation may occur warranting strict monitoring of the disease and effective treatment of exacerbations...
December 2015: Odonto-stomatologie Tropicale, Tropical Dental Journal
Bhuvanesh Govind, Esteban Gnass, Geno Merli, Luis Eraso
Heparin is one of the most widely prescribed medications. Cutaneous reactions distant to the injection site are rare and under-reported in the literature. We present an elderly man with history of CNS lymphoma who underwent treatment of a deep venous thrombosis with enoxaparin and subsequently developed well demarcated bullous lesions within days of heparin initiation. The exact pathophysiology is not well understood. Hemorrhagic bullous dermatosis is a rare cutaneous reaction that is temporally associated with the initiation of heparin products...
2016: Hospital Practice (Minneapolis)
Yusuf Moolla
A young woman presented with generalised tense blisters. There had been no previous drug exposure and she had no clinical signs of autoimmune disease or evidence of sepsis. Given the abrupt onset and clinical scenario, a skin punch biopsy was performed and a tentative diagnosis of linear IgA bullous dermatosis (LABD) was made. Dapsone, an immunomodulatory sulfone that has been supported for use in LABD by case reports and clinical observation, was administered with an adjunctive oral corticosteroid to accelerate resolution...
March 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
Takashi Hashimoto, Daisuke Tsuruta, Atsushi Yasukochi, Hisayoshi Imanishi, Hideharu Sekine, Teizo Fujita, Hideki Wanibuchi, Min Gi, Sarolta Kárpáti, Cassian Sitaru, John J Zone, Daisuke Endo, Shinichi Abe, Tomoya Nishino, Takehiko Koji, Norito Ishii
There has been no previous systematic study of bullous skin diseases with granular basement membrane zone deposition exclusively of C3. In this study we collected 20 such patients, none of whom showed cutaneous vasculitis histopathologically. Oral dapsone and topical steroids were effective. Various serological tests detected no autoantibodies or autoantigens. Direct immunofluorescence for various complement components revealed deposition only of C3 and C5-C9, indicating that no known complement pathways were involved...
August 23, 2016: Acta Dermato-venereologica
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