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Bullous dermatosis

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https://www.readbyqxmd.com/read/29929566/bullous-pemphigoid-in-an-infant-a-case-report
#1
Oscar Thabouillot, Julien Le Coz, Nicolas-Charles Roche
A seven-month-old girl was referred to the emergency department (ED) after a general practitioner suspected Steven-Johnson syndrome. Actually, the diagnosis of bullous pemphigoid (BP) was made based on biopsies; BP is a rare, autoimmune skin disease involving the presence of blisters known as bullae. The child was efficiently treated with topical steroids. This case shows the importance of the ED physician's prior knowledge of BP so that a differential diagnosis with other autoimmune diseases (dermatosis, pemphigus) can be made...
June 22, 2018: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29924252/adult-linear-iga-bullous-dermatosis-report-of-three-cases
#2
Taila Yuri Siqueira Machado, Milvia Maria Simões E Silva Enokihara, Tatiana Miyuki Iida, Adriana Maria Porro
Linear immunoglobulin A bullous dermatosis is a rare autoimmune disease that usually has an excellent prognosis in childhood; however, its control is more difficult in adults. It presents heterogeneous clinical manifestations and is frequently confused with other bullous diseases such as bullous pemphigoid and Duhring's dermatitis herpetiformis. Dermatologists' awareness of this disease contributes to early diagnosis and appropriate treatment. We thus report three cases of linear immunoglobulin A dermatosis in adults...
June 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29867971/clinical-and-immunological-study-of-30-cases-with-both-igg-and-iga-anti-keratinocyte-cell-surface-autoantibodies-toward-the-definition-of-intercellular-igg-iga-dermatosis
#3
Takashi Hashimoto, Kwesi Teye, Koji Hashimoto, Katarzyna Wozniak, Daisuke Ueo, Sakuhei Fujiwara, Kazuhiro Inafuku, Yorihisa Kotobuki, Ines Lakos Jukic, Branka Marinović, Anna Bruckner, Daisuke Tsuruta, Tamihiro Kawakami, Norito Ishii
Several sporadic cases, in which direct and indirect immunofluorescence studies simultaneously detected IgG and IgA autoantibodies to keratinocyte cell surfaces, have been reported mainly under the name of IgG/IgA pemphigus. However, there have been no systematic studies for this condition. In this study, we collected 30 cases of this condition from our cohort of more than 5,000 autoimmune bullous disease cases, which were consulted for our diagnostic methods from other institutes, and summarized their clinical and immunological findings...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29782306/urticarial-lesions-in-a-pregnant-woman
#4
Sergio Santos-Alarcón, Cesar Benavente-Villegas, Isabel García-Briz, Magdalena Moneva-Léniz, Celia Sanchis-Sánchez, Almudena Mateu-Puchades
Dear Editor, Gestational pemphigoid (GP) is a rare autoimmune bullous dermatosis in pregnancy. GP usually occurs during the second or third month of pregnancy. It clinically manifests as the development of either early-onset urticarial lesions or late-onset subepidermal blisters that may linger for weeks or even months. Herein we report the case of a 45-year-old woman with the distinctive clinical onset of GP. A forty-five-year-old woman, gravida I, para 0, at 27 weeks gestation, was referred for evaluation to our Department with an extensive pruritic eruption that had developed over the previous 7 days...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29782303/clindamycin-induced-maculopapular-exanthema-with-preferential-involvement-of-striae-distensae-a-koebner-phenomenon
#5
Benigno Monteagudo, Miguel Cabanillas, Pilar Iriarte, Aquilina Ramírez-Santos, Elvira León-Muinos, Daniel González-Vilas, Óscar Suárez-Amor
Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Cutaneous adverse reactions are usually maculopapular exanthemas, although hypersensitivity syndrome, acute generalized exanthematous pustulosis, and Stevens-Johnson syndrome have also been reported (1). We report the case of a patient with a maculopapular rash triggered by clindamycin who developed cutaneous lesions on striae distensae (SD). A 47-year-old woman was referred to our clinic for pruritic cutaneous lesions which had started 6 days earlier...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29763476/drug-induced-linear-iga-bullous-dermatosis-in-a-patient-with-a-vancomycin-impregnated-cement-spacer
#6
Kelsie Riemenschneider, Daren A Diiorio, John A Zic, Matthew R Livingood, Jo-David Fine, Jennifer G Powers, Jeffrey P Zwerner, Eric Tkaczyk
Linear IgA bullous dermatosis (LABD) is an autoimmune blistering rash caused by IgA autoantibodies against the epidermal basement membrane zone. It commonly is drug induced, often in association with systemic vancomycin. We report a case of a previously healthy 77-year-old man who developed a diffuse macular rash and hemorrhagic bullae on the left leg 10 days after placement of a vancomycin-impregnated cement spacer (VICS) during a revision knee arthroplasty and initiation of postoperative treatment with intravenous (IV) vancomycin...
April 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29762916/painful-circumscribed-bullous-dermatosis-of-the-left-hand-after-contact-with-african-four-toed-hedgehogs
#7
Silke Gebauer, Silke Uhrlass, Daniela Koch, Constanze Krüger, Nadine Rahmig, Uta-Christina Hipler, Pietro Nenoff
No abstract text is available yet for this article.
May 15, 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29667608/linear-iga-bullous-dermatosis-induced-by-diclofenac-sodium
#8
Sarita Sanke, Abhinav Kumar, Ram Chander
No abstract text is available yet for this article.
April 12, 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29566927/blistering-diseases-in-the-mature-patient
#9
Ines Lakoš Jukić, Sandra Jerković Gulin, Branka Marinović
Autoimmune blistering diseases (AIBD) are a group of chronic diseases affecting the skin and mucous membranes, with different presentation, clinical course, histologic and immunopathologic findings, and different therapeutic approach. Blisters develop as a result of autoantibodies directed against distinct adhesion structures within desmosomes or within the basement membrane zone. The most common AIBD that develops in the elderly is bullous pemphigoid (previously also named "pemphigoid senilis"), but mature patients can also present with other AIBD as mucous membrane pemphigoid, epidermolysis bullosa acquisita, paraneoplastic pemphigus, pemphigus vulgaris, pemphigus foliaceus, linear IgA dermatosis, and dermatitis herpetiformis...
March 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29551123/bullosis-diabeticorum-a-neglected-bullous-dermatosis
#10
Ramya Vangipuram, Tiffany Hinojosa, Daniel J Lewis, Christopher Downing, Caleb Hixson, Julio César Salas-Alanis, Stephen K Tyring
A 75-year-old African-American man presented with a 3-year history of painless, fluid-filled blisters, for which his primary care physician had treated him with doxycycline, cephalexin, and topical corticosteroids, with no significant improvement. The blisters had ruptured spontaneously and healed with scarring. He denied antecedent trauma. His medical history was remarkable for insulin-dependent type 2 diabetes mellitus, hypertension, hypercholesterolemia, primary cutaneous melanoma status-post excision, and breast cancer status-post mastectomy and chemotherapy...
2018: Skinmed
https://www.readbyqxmd.com/read/29527024/cutaneous-adverse-reactions-of-chemotherapy-in-cancer-patients-a-clinicoepidemiological-study
#11
Saumita Ghosh Biswal, Rajesh Datt Mehta
Background: The diagnosis of cutaneous adversities in the cancer patient is especially difficult, given the complexity of their illness and combination protocols used for the treatment. The present study was undertaken to know the spectrum of cutaneous adversities in patients undergoing chemotherapy and the drug(s) most commonly associated with it. Materials and Methods: A total of 1000 patients with malignancies under chemotherapy in the oncology ward and outpatient department were screened in this observational study from January 2013 to February 2015...
January 2018: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/29502441/uncomplicated-neonatal-linear-iga-bullous-dermatosis-a-case-report
#12
Matthew T Mazurek, Rudaina Banihani, Jonathan Wong, Miriam Weinstein, Abdulaziz Alnutayfi, Yousef Etoom
No abstract text is available yet for this article.
March 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29469749/trimethoprim-sulfamethoxazole-induced-linear-iga-bullous-disease-presenting-as-toxic-epidermal-necrolysis
#13
T Baltazard, F Dhaille, S Duvert-Lehembre, C Lok, G Chaby
BACKGROUND: Linear IgA bullous dermatosis (LABD) is an autoimmune blistering skin disorder characterized by linear IgA deposits along the dermoepidermal junction. Usually idiopathic, LABD can be drug-induced. OBJECTIVE: To report the atypical characteristics of a case of trimethoprim-sulfamethoxazole-induced LABD presenting as toxic epidermal necrolysis (TEN). METHODS: A 63-year-old woman treated with trimethoprim-sulfamethoxazole for Pneumocystis jirovecii infection developed a generalized maculopapular rash with herpetiform lesions, rosette-like lesions, and tense bullae with Nikolsky sign...
August 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469740/a-toxic-epidermal-necrolysis-like-presentation-of-linear-iga-bullous-dermatosis-treated-with-dapsone
#14
Julie K Nguyen, Misha V Koshelev, Bartley J Gill, Jessica Boulavsky, Abdul Hafeez Diwan, Harry Dao
Linear IgA bullous dermatosis is a rare autoimmune vesiculobullous disease characterized by linear deposition of IgA along the basement membrane zone. It is classically idiopathic, but may also arise secondary to drug exposure. A heterogeneous spectrum of clinical features has been described, including a rare, morbid variant mimicking toxic epidermal necrolysis. Herein, we present a case of vancomycin-induced linear IgA bullous dermatosis that manifested clinically as toxic epidermal necrolysis and resolved with dapsone therapy...
August 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469702/infantile-bullous-pemphigoid-with-string-of-pearls-sign
#15
Inês Raposo, Susana Machado, Rita Sampaio, Manuela Selores
Bullous pemphigoid (BP) is an immune mediated bullous disease that is manifested by urticarial plaques with superimposed subepidermal blisters and significant pruritus. It is generally found in the elderly, but is rare in the pediatric population. A 5-month-old girl previously diagnosed with hand-foot-mouth disease was examined in our dermatology department owing to vesicles and bullae, initially located to the hands and feet, which progressed with new lesions. Tense vesicles and bullae distributed in an annular string of pearls pattern on the abdomen and facial and cervical regions were noted...
July 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29447641/flame-figures-in-linear-iga-bullous-dermatosis-a-novel-histopathologic-finding
#16
E Fulton, F Jan, M J Zimarowski
BACKGROUND: Linear IgA bullous dermatosis (LABD) is an autoimmune subepidermal blistering disease usually with a neutrophil rich inflammatory infiltrate, and characterized by linear IgA deposition at the basement membrane zone (BMZ), and neutrophil predominant dermal inflammation. We report a case of LABD with numerous eosinophils and flame figure formation, a unique histopathologic finding not previously reported. A 69-year-old woman presented with a rapidly progressive, intensely pruritic rash over forearms, breasts, axillae, hips, and thighs...
November 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29447635/sublamina-densa-type-linear-iga-bullous-dermatosis-with-iga-autoantibodies-specific-for-type-vii-collagen-a-case-report-and-clinicopathological-review-of-32-cases
#17
REVIEW
Natsuko Utsunomiya, Takenao Chino, Noritaka Oyama, Akira Utsunomiya, Yuka Yamaguchi, Wataru Takashima, Atsushi Tokuriki, Minoru Hasegawa
Linear IgA bullous dermatosis (LABD) is a rare autoimmune bullous disorder characterized by linear deposits of IgA at the basement membrane zone(BMZ) and/or by circulating IgA anti-BMZ antibodies. Comparing with other immuno-bullous diseases, LABD represents a heterogeneous disease entitywith diversity of pathogenic IgA autoantibodies to different hemidesmosomal antigens and an association with malignancies and occasional drug use. We herein present an 82-year-old Japanese man with LABD, whose indirect immunofluorescence using 1M NaCl-split skin showed positive staining for IgA at the dermal side alone...
November 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29410066/vancomycin-mediates-iga-autoreactivity-in-drug-induced-linear-iga-bullous-dermatosis
#18
Jun Yamagami, Yoshio Nakamura, Keisuke Nagao, Takeru Funakoshi, Hayato Takahashi, Akiko Tanikawa, Takahisa Hachiya, Toshiyuki Yamamoto, Akemi Ishida-Yamamoto, Toshihiro Tanaka, Noriki Fujimoto, Chikako Nishigori, Tetsuya Yoshida, Norito Ishii, Takashi Hashimoto, Masayuki Amagai
Vancomycin (VCM) is known to induce linear IgA bullous dermatosis (LAD). However, in contrast to conventional LAD, in which circulating IgA autoantibodies against basement membrane proteins are commonly detected, patient sera from VCM-induced LAD yields negative results in indirect immunofluorescence microscopy, and the targeted autoantigen remains undetermined. By using sera from a typical patient with VCM-induced LAD, we identified that co-incubation of sera with VCM resulted in linear IgA deposition at the basement membrane zone by indirect immunofluorescence...
February 2, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29389324/increasing-the-complement-of-therapeutic-options-in-bullous-pemphigoid
#19
Carolyn J Kushner, Aimee S Payne
Bullous pemphigoid is a potentially life-threatening autoantibody-mediated dermatosis characterized by blister formation. Experimental mouse models of bullous pemphigoid feature complement-induced inflammation and tissue damage. Kasprick et al. now provide preclinical data that utilize ex vivo human skin assays and support testing of complement inhibition as a therapeutic strategy in human bullous pemphigoid.
February 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29360890/lichen-planus-pemphigoides-treated-with-ustekinumab
#20
Raymond R Knisley, Angelo A Petropolis, Vernon T Mackey
A 71-year-old woman presented with pink to violaceous, flat-topped, polygonal papules on the volar wrists, extensor elbows, and bilateral lower legs of 3 years' duration. She also had erythematous, violaceous, infiltrated plaques with microvesiculation on the bilateral thighs of several months' duration. She reported pruritus, burning, and discomfort. Her medical history included type 2 diabetes mellitus, hypertension, and asthma with no history of skin rashes. Workup revealed lichen planus pemphigoides (LPP), a rare papulosquamous and vesiculobullous dermatosis that shares features of both lichen planus (LP) and bullous pemphigoid (BP)...
December 2017: Cutis; Cutaneous Medicine for the Practitioner
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