keyword
https://read.qxmd.com/read/38516926/single-locus-hla-sequencing-with-the-nanopore-technology-for-hla-disease-association-diagnosis
#1
JOURNAL ARTICLE
Magali Devriese, Julien Rouquie, Sephora Da Silva, Nadine Benassaya, Lucie Maillard, Mathieu Dewez, Sophie Caillat-Zucman, Gregory Werner, Jean-Luc Taupin
Associations between HLA genotype and disease susceptibility encompass almost all the classic HLA loci. The level of typing resolution enabling a correct identification of an HLA disease susceptibility gene depends on the disease itself and/or on the accumulated knowledge about the molecular involvement of the HLA allele(s) engaged. Therefore, the application of Next Generation Sequencing technologies to HLA disease association, which would improve typing resolution, could prove useful to better understand disease severity...
March 2024: HLA
https://read.qxmd.com/read/38507442/a-case-of-bullous-pemphigoid-following-administration-of-anti-il-31-receptor-a-antibody
#2
JOURNAL ARTICLE
Ryosuke Masuyuki, Emi Sato, Shinichi Imafuku
Bullous pemphigoid (BP), an autoimmune bullous dermatosis, occurs predominantly in older individuals. Nemolizumab, a humanized monoclonal antibody against the interleukin (IL)-31 receptor A, is used to treat severe atopic dermatitis (AD) in Japan. However, it can cause several adverse events, such as exacerbation of AD, erythema, and eosinophilia. Herein, we describe a case of prurigo-type AD developing BP after nemolizumab administration. A 62-year-old man with prurigo-type AD and asthma presented with serious, refractory itching...
March 20, 2024: Journal of Dermatology
https://read.qxmd.com/read/38478666/linear-iga-bullous-dermatosis-associated-with-immunotherapy
#3
JOURNAL ARTICLE
Bahar Momin, Tue F Nguyen, Daniel Glade, Alison Messer
Linear IgA bullous dermatosis (LABD) is a rare mucocutaneus blistering autoimmune disease caused by IgA autoantibodies. Its clinical manifestation can be indistinguishable from bullous pemphigoid (BP), a similar autoimmune bullous disease caused by IgG and IgE autoantibodies. Although BP has been reported as an adverse cutaneous effect of immunotherapy, LABD has rarely been associated with immunotherapy in the literature. We present the case of a 67-year-old woman with metastatic ovarian cancer receiving anti-PD1 and anti-CTLA4 with new onset pruritic tense bullae to the trunk, hands, elbows (in annular distribution) that occurred after immunotherapy...
December 15, 2023: Dermatology Online Journal
https://read.qxmd.com/read/38465552/linear-iga-bullous-dermatosis-in-association-with-nodal-peripheral-t-cell-lymphoma-with-a-t-follicular-helper-phenotype-and-multiple-myeloma-a-case-report-and-literature-review
#4
JOURNAL ARTICLE
Momone Masuda, Yukiko Kiniwa, Asuka Mikoshiba, Mariko Kasuga, Sayaka Nishina, Misae Oguchi, Norito Ishii, Ryuhei Okuyama
No abstract text is available yet for this article.
December 1, 2023: European Journal of Dermatology: EJD
https://read.qxmd.com/read/38439725/neutrophilic-dermatosis-of-the-hands-a-case-report
#5
JOURNAL ARTICLE
Reza Yaghoobi, Nooshin Bagherani, Bruce R Smoller, Nader Pazyar
Neutrophilic dermatosis of the hands (NDDH) is a localized variant of Sweet's syndrome which has been recently introduced. Strutton et al.in 1996 and then in Galaria et al. in 2000 reported cases with violaceous papulonodules on the dorsal surfaces of the hands with histopathological findings of a neutrophilic dermatosis in association with leukocytoclasia, but clinically and histologically without true vasculitis findings. Eventually, they proposed the term NDDH for these lesions (1,2). A 46-year-old man was referred to our outpatient dermatology clinic with a painful ulcerative lesion on the dorsal side of the left hand that had been present for one year...
December 2023: Acta Dermatovenerologica Croatica: ADC
https://read.qxmd.com/read/38421060/s2k-guidelines-on-diagnosis-and-treatment-of-linear-iga-dermatosis-initiated-by-the-european-academy-of-dermatology-and-venereology
#6
JOURNAL ARTICLE
Frédéric Caux, Aikaterini Patsatsi, Meropi Karakioulaki, Emiliano Antiga, Eulalia Baselga, Luca Borradori, Marzia Caproni, Adela R Cardones, Nisha Suyien Chandran, Sören Dräger, Kossara Drenovska, Matthias Goebeler, Claudia Günther, Silke C Hofmann, Dimitrios Ioannides, Pascal Joly, Branka Marinović, Elena Biancamaria Mariotti, Angelo Valerio Marzano, Kimberly D Morel, Dedee F Murrell, Catherine Prost, Miklós Sárdy, Jane Setterfield, Dusan Skiljevic, Soner Uzun, Snejina Vassileva, Giovanna Zambruno, Enno Schmidt
INTRODUCTION: Linear IgA dermatosis (LAD) is a rare subepidermal autoimmune bullous disease (AIBD) defined by predominant or exclusive immune deposits of immunoglobulin A at the basement membrane zone of skin or mucous membranes. This disorder is a rare, clinically and immunologically heterogeneous disease occurring both in children and in adults. The aim of this project is to present the main clinical features of LAD, to propose a diagnostic algorithm and provide management guidelines based primarily on experts' opinion because of the lack of large methodologically sound clinical studies...
February 29, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/38406046/a-case-of-bullous-sweet-s-syndrome-associated-with-esophageal-adenocarcinoma
#7
Adriana G Bagos-Estevez, Sarah Moore, Leslie Turner, Brooke Baldwin
Sweet's syndrome (SS), or acute febrile neutrophilic dermatosis, characteristically presents with fever, dermal neutrophilic infiltrates, and neutrophilia. It typically manifests as tender erythematous plaques; however, various variants are documented, including bullous. Malignancy-associated Sweet's syndrome (MASS) can present as a paraneoplastic syndrome in those with established cancers or with undiagnosed malignancies. We present a 72-year-old male with a three-day history of a progressive bullous, erythematous papular rash starting on his right forearm and spreading to his extremities, trunk, palms, and soles...
January 2024: Curēus
https://read.qxmd.com/read/38398470/linear-iga-bullous-dermatosis-in-korea-using-the-nationwide-health-insurance-database
#8
JOURNAL ARTICLE
Yu Rim Kim, Ji Hyeon Kim, Sang Won Kim, Jae Min Lee, Jacob S Bae
(1) Background: Linear immunoglobulin A bullous dermatosis (LABD) is a rare autoimmune, subepidermal blistering disease, characterized by linear IgA deposits along the epidermal basement membrane. LABD is idiopathic and is associated with medication and systemic autoimmune diseases. (2) Methods: We investigated the demographic characteristics, disease course, causative agents, and associated diseases in Korean patients with LABD. The Korean Health Insurance Review and Assessment Service database was used to obtain data...
February 19, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38389191/patients-suffering-from-dystrophic-epidermolysis-bullosa-are-prone-to-developing-autoantibodies-against-skin-proteins-a-longitudinal-confirmational-study
#9
JOURNAL ARTICLE
J Bremer, H H Pas, G F H Diercks, H J Meijer, S M van der Molen, A M Nijenhuis, L L van Nijen-Vos, P Morandé, M J Yubero, F Palisson, I Fuentes, A M G Pasmooij
Epidermolysis bullosa (EB) is a heritable skin blistering disease caused by variants in genes coding for proteins that secure cell-cell adhesion and attachment of the epidermis to the dermis. Interestingly, several proteins involved in inherited EB are also associated with autoimmune blistering diseases (AIBD). In this study, we present a long-term follow-up of 15 patients suffering from recessive dystrophic or junctional EB. From these patients, 62 sera were analysed for the presence of autoantibodies associated with AIBD...
February 2024: Experimental Dermatology
https://read.qxmd.com/read/38378007/linear-iga-bullous-dermatosis-of-childhood-retrospective-single-center-cohort
#10
JOURNAL ARTICLE
Katherine L Wang, Julia S Lehman, Dawn M R Davis
Linear IgA bullous dermatosis (LABD) is a rare autoimmune blistering disorder impacting children and adults. In this single-center retrospective chart review of pediatric patients with LABD at a large tertiary referral center, we report the unifying and unique clinical features of 10 pediatric patients. Patients typically presented with the "cluster of jewels" sign (n = 6; 60%), mucous membrane involvement (n = 5; 50%) and had a mean disease duration of 38 months; six patients (60%) required inpatient admission for management of their skin disease, including all five patients who had mucous membrane involvement...
February 20, 2024: Pediatric Dermatology
https://read.qxmd.com/read/38368951/u-serrated-and-n-serrated-patterns-in-bullous-pemphigoid-epidermolysis-bullosa-acquisita-and-bullous-lupus-a-retrospective-observational-study
#11
JOURNAL ARTICLE
Catherine S Barker, Evelyn Bruner, Sally Self, Dirk M Elston
No abstract text is available yet for this article.
February 16, 2024: Journal of the American Academy of Dermatology
https://read.qxmd.com/read/38325546/-translated-article-heparin-induced-bullous-hemorrhagic-dermatosis-an-underdiagnosed-reaction
#12
Susana E Pérez, Ana C Torre, María Echeverría, Maria J Cura, Mariana Caviedes, Luis D Mazzuoccolo
No abstract text is available yet for this article.
February 5, 2024: Actas Dermo-sifiliográficas
https://read.qxmd.com/read/38313964/bullous-mastocytosis-a-rare-variant-of-diffuse-cutaneous-mastocytosis
#13
Shamma Khamis Almheiri, Jaheersha Pakran, Amani Abdulla AlFalasi, Reem El Bahtimi
Mastocytosis is a disease of the mast cells caused by an increase in the number of mast cells due to abnormal proliferation. The disease is associated with a mutation in the c-kit gene, which is a key factor in the development of mast cells. Mastocytosis is classified into two main groups, namely, cutaneous and systemic mastocytosis, based on the site of mast cell accumulation. In cutaneous mastocytosis, the cells purely gather in the skin. In contrast, systemic mastocytosis must affect an internal organ, including the bone marrow, lymph nodes, liver, spleen, and/or the gastrointestinal tract with or without skin involvement...
January 2024: Curēus
https://read.qxmd.com/read/38304552/multiple-abscess-collections-antibiotics-or-steroids
#14
Philippe Raphael Dias, Levin Bolt, Christof Iking-Konert, Mattia Arrigo, Lars C Huber
Aseptic abscess syndrome (AAS) is a medical rarity. The combination of multiple abscess collections in different organs, negative microbiological studies, and the association with an inflammatory bowel disease is highly suggestive for an AAS. The AAS is an acute neutrophilic dermatosis, so "generalized pyoderma gangraenosum" or "generalized bullous sweet syndrome" might be used synonymously. It is important to note that the diagnosis of an AAS can be made only after careful exclusion of an infectious disease...
2024: Case Reports in Immunology
https://read.qxmd.com/read/38292583/letter-in-reply-linear-iga-bullous-dermatosis-treated-with-dupilumab-in-a-pediatric-patient-with-glucose-6-phosphate-dehydrogenase-deficiency
#15
JOURNAL ARTICLE
Sonal Muzumdar, Lorin A Bibb, Brett Sloan, Michael Murphy, Mary Wu Chang
No abstract text is available yet for this article.
February 2024: JAAD Case Reports
https://read.qxmd.com/read/38251749/adult-onset-linear-iga-bullous-dermatosis-a-retrospective-single-center-cohort-study-of-81-patients-and-literature-review
#16
JOURNAL ARTICLE
Katherine L Wang, Julia S Lehman, Austin Todd, Dawn M R Davis
BACKGROUND: Linear IgA bullous dermatosis (LABD) is a rare autoimmune blistering disorder that may be drug-induced or paraneoplastic. We aim to characterize features of LABD and determine differentiating factors among idiopathic, drug-induced, or malignancy-associated diseases. METHODS: We conducted a single-center retrospective chart review of adult patients with linear IgA bullous dermatosis at a large tertiary referral center and a literature review of adult linear IgA bullous dermatosis...
January 22, 2024: International Journal of Dermatology
https://read.qxmd.com/read/38173884/bullous-pemphigoid-malignant-acanthosis-nigricans-and-erysipeloid-carcinoma-in-a-woman-with-gastric-adenocarcinoma
#17
Saman Al-Zahawi, Yasaman Sadeghi, Vahidesadat Azhari, Hamidreza Mahmoudi, Maryam Daneshpazhooh
KEY CLINICAL MESSAGE: Bullous pemphigoid did not follow the course of Gastric Carcinoma relapse and remisson, unlike the malignant acanthosis nigricans which was in alignment with the paraneoplastic effect of the Gastric Carcinoma. ABSTRACT: Acanthosis nigricans (AN) is a dermatosis characterized by the presence of hyperpigmented, velvety cutaneous thickening in the flexural areas, posterior neck, and occasionally the extensor surfaces of hand, face, and oral mucosa...
January 2024: Clinical Case Reports
https://read.qxmd.com/read/38130914/lichenoid-drug-reaction-after-ipilimumab-nivolumab-combination-therapy-a-case-report
#18
Zonía Robenne Moore, Dalit Zajdman-Faitelson, Arely Tamariz Campillo, Diana Karen Brito Bustillos, Sonia Toussaint-Caire, Cristina Berumen-Glinz
Nivolumab (PD-1 inhibitor) and ipilumumab (CTLA-4 inhibitor) are recently approved checkpoint inhibitors for treatment of non-small cell lung cancer. Immune-related adverse events related to the usage of checkpoint inhibitors are growing with their popularity. We present the case of a patient in combination treatment of nivolumab and ipilimumab who developed a lichenoid drug reaction, notable because it worsened to a bullous lichenoid drug reaction. Treatment with prednisone and withdrawal of checkpoint inhibitors aided in clinical resolution...
2023: SAGE Open Medical Case Reports
https://read.qxmd.com/read/38130534/drug-induced-linear-iga-bullous-dermatosis-in-an-oncologic-patient
#19
Luz A Quispe-Gárate, Renzo B Espinoza-Escudero, Carlos Salas-Rivera, Gadwyn Sánchez-Félix
Blister formation in the skin can result from various conditions, such as autoimmune disorders, drug reactions, infections, etc. A comprehensive patient assessment may offer clues for diagnosis. Linear IgA bullous dermatosis (LABD) is a rare subepidermal blistering disorder characterized by the deposition of IgA at the basement membrane zone of the skin and mucous membranes. Here, we describe a case of a patient with a new onset of painless blisters located in the skin and oral mucosa after initiating antibiotic treatment...
November 2023: Curēus
https://read.qxmd.com/read/38099111/immunohistochemical-evaluation-of-c4d-and-c3d-markers-in-bullous-pemphigoid-as-a-substitute-for-direct-immunofluorescence-technique
#20
JOURNAL ARTICLE
Mahsa Akbari Oryani, Naser Tayebi-Meybodi, Yalda Nahidi, Mohsen Soltani Sabi, Monavar Afzal Aghaei
BACKGROUND: There are several methods for the diagnosis of autoimmune bullous disease. Direct immunofluorescent (DIF) testing is an important diagnostic method in the diagnosis of immunobullous disease but requires skilled pathologist, fresh tissue and well-equipped laboratory to perform the procedure. The immunohistochemistry analysis of C4d and C3d is easily compared with other methods. This study was conducted to assess the value of immunohistochemistry (IHC) analysis for expressions of C3d and C4d in the diagnosis of bullous pemphigoid (BP)...
2023: Indian Journal of Dermatology
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