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https://www.readbyqxmd.com/read/29160600/current-evidence-of-cannabinoid-based-analgesia-obtained-in-preclinical-and-human-experimental-settings
#1
REVIEW
J Lötsch, I Weyer-Menkhoff, I Tegeder
Cannabinoids have a long record of recreational and medical use and become increasingly approved for pain therapy. This development is based on preclinical and human experimental research summarized in this review. Cannabinoid CB1 receptors are widely expressed throughout the nociceptive system. Their activation by endogenous or exogenous cannabinoids modulates the release of neurotransmitters. This is reflected in antinociceptive effects of cannabinoids in preclinical models of inflammatory, cancer and neuropathic pain, and by nociceptive hypersensitivity of cannabinoid receptor-deficient mice...
November 21, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29160385/usual-interstitial-pneumonia-typical-possible-and-inconsistent-patterns
#2
Pedro Paulo Teixeira E Silva Torres, Marcelo Fouad Rabahi, Maria Auxiliadora Carmo Moreira, Gustavo de Souza Portes Meirelles, Edson Marchiori
Idiopathic pulmonary fibrosis is a severe and progressive chronic fibrosing interstitial lung disease, a definitive diagnosis being established by specific combinations of clinical, radiological, and pathological findings. According to current international guidelines, HRCT plays a key role in establishing a diagnosis of usual interstitial pneumonia (UIP). Current guidelines describe three UIP patterns based on HRCT findings: a typical UIP pattern; a pattern designated "possible UIP"; and a pattern designated "inconsistent with UIP", each pattern having important diagnostic implications...
September 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29155149/drug-hypersensitivity-we-need-to-do-more
#3
EDITORIAL
Werner J Pichler, Daniel Yerly
No abstract text is available yet for this article.
November 16, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29152493/a-pilot-study-evaluating-biomarker-development-for-drug-induced-chronic-eczematous-eruptions-of-aging-individuals
#4
Erika Mae Summers, Nicholas Ray Blickenstaff, Garrett Curtis Coman, Thomas Bernd Martins, Harry Raymond Hill, Richard Dennis Sontheimer
Background: Identifying the drug(s) responsible for drug-induced chronic eczematous eruptions of aging individuals (CEEA) is a clinical challenge in patients on multiple medications. Reliable in vitro testing methods and biomarkers are needed to identify the causative agent and allow simultaneous assessment of T-cell responses to multiple drugs being taken concurrently. This study examined the feasibility of using in vitro, drug-specific T cell activation responses as a biomarker for drug-induced CEEA...
October 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29148816/assessment-of-anti-piperacillin-igg-binding-to-structurally-related-drug-protein-adducts
#5
Mohammed Amali, Rosalind Jenkins, Xioali Meng, Lee Faulkner, Paul Whitaker, Daniel Peckham, B Kevin Park, Dean John Naisbitt
The risk of developing hypersensitivity to alternative antibiotics is a concern for penicillin hypersensitive patients and healthcare pro-viders. Herein we use piperacillin hypersensitivity as a model to explore the reactivity of drug-specific IgG against alternative β-lactam protein adducts. Mass spectrometry was used to show the drugs (amoxicillin, flucloxacillin, benzyl penicillin, aztreonam and pipera-cillin) bind to similar lysine residues on the protein carrier bovine serum albumin. However, the hapten-specific IgG antibodies found in piperacillin hypersensitive patient plasma did not bind to other β-lactam protein conjugates...
November 17, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29141066/vancomycin-infiltrate-induced-dermatitis-mimicking-bullous-cellulitis
#6
Sowmya Nanjappa, Matthew Snyder, John N Greene
<p>Extravasation of medications can manifest as tenderness, pain, tissue necrosis, and thrombophlebitis and lead to infection and severe long-term complications. Risk factors for leakage of medications include mechanical and pharmacologic mechanisms such as cannulation technique, vasoconstriction, and cytotoxicity. Well-known vesicants like anthracyclines, vinca alkaloids, and vasopressors are usually administered with proper caution. Often overlooked are many antimicrobial agents, which typically act via differences in osmolality and pH...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29131036/the-immunogenicity-of-biologic-therapies
#7
Sandra Garcês, Jocelyne Demengeot
Virtually all therapeutic proteins (biologics) elicit an immune response with the consequent production of anti-drug antibodies (ADA). The majority of ADA to therapeutic monoclonal antibodies (mAbs) are directed against the antigen-binding site of the therapeutic mAb, and hence are neutralizing. This nature of the ADA response explains why fully human antibodies can still be highly immunogenic. The detection of ADA is technically challenging and all assays have limitations, namely a limited capacity in detecting ADA in the presence of a drug due to immune complex (IC) formation, which may underestimate the ADA incidence...
2018: Current Problems in Dermatology
https://www.readbyqxmd.com/read/29129745/fluorescent-light-up-acridine-orange-derivatives-bind-and-stabilize-kras-22rt-g-quadruplex
#8
Josué Carvalho, Edgar Pereira, Julien Marquevielle, Maria P C Campello, Jean-Louis Mergny, António Paulo, Gilmar F Salgado, João A Queiroz, Carla Cruz
KRAS is often found mutated in lethal cancers and should be an important target for anticancer drug development. However, no effective inhibitor has been reported so far, prompting the scientific community to describe the RAS proteins as nearly "undruggable". Recent approaches developed to modulate KRAS protein expression comprises the targeting of G-quadruplex (G4) structures formed within the nuclease hypersensitive element of KRAS promoter region, by designing small and specific ligands to stabilize the tertiary fold and reduce gene expression...
November 9, 2017: Biochimie
https://www.readbyqxmd.com/read/29129690/monoterpenoid-perillyl-alcohol-impairs-metabolic-flexibility-of-candida-albicans-by-inhibiting-glyoxylate-cycle
#9
Moiz A Ansari, Zeeshan Fatima, Kamal Ahmad, Saif Hameed
The metabolic pathway such as glyoxylate cycle (GC) enables Candida albicans, to survive under glucose deficient conditions prevalent in the hostile niche. Thus its key enzymes (Isocitrate lyase; ICL and malate synthase; MLS) represent attractive targets against C. albicans. We have previously reported the antifungal potential of a natural monoterpenoid perillyl alcohol (PA). The present study uncovers additional role of PA as a potent GC inhibitor. We explored that PA phenocopied ICL1 deletion mutant and were hypersensitive under low carbon utilizing conditions...
November 9, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29125719/safety-pharmacokinetics-and-immunogenicity-of-obiltoxaximab-after-intramuscular-administration-to-healthy-humans
#10
Christa F Nagy, Timothy S Leach, Alex King, Robert Guttendorf
Inhalational anthrax is a highly lethal infection caused by Bacillus anthracis and a serious bioterrorism threat. Protective antigen (PA) is a critical component required for the virulence of Bacillus anthracis. Obiltoxaximab, a high-affinity monoclonal antibody that neutralizes PA, is approved in the United States for intravenous use for the treatment of inhalational anthrax in combination with appropriate antibacterial drugs and for prophylaxis of inhalational anthrax when alternative therapies are not available or appropriate...
November 10, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29122159/opioid-analgesic-drugs-misuse-toxicity-and-hypersensitivity
#11
EDITORIAL
Brian A Baldo
No abstract text is available yet for this article.
November 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29122155/rituximab-hypersensitivity-evaluation-desensitization-and-potential-mechanisms
#12
Johnson T Wong, Aidan Long
BACKGROUND: Rituximab (Rituxan) hypersensitivity (RITS) can be severe and limits the ability to further administer the treatment. Understanding its pattern and desensitization may permit administration in difficult cases. OBJECTIVE: Analyze RITS patient characteristics, hypersensitivity pattern, and desensitization outcomes to optimize management. METHODS: Twenty-five patients with RITS were referred to the Allergy/Immunology Unit at Massachusetts General Hospital over 5 1/2 years...
November 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29118215/adolescence-and-reward-making-sense-of-neural-and-behavioral-changes-amid-the-chaos
#13
Deena M Walker, Margaret R Bell, Cecilia Flores, Joshua M Gulley, Jari Willing, Matthew J Paul
Adolescence is a time of significant neural and behavioral change with remarkable development in social, emotional, and cognitive skills. It is also a time of increased exploration and risk-taking (e.g., drug use). Many of these changes are thought to be the result of increased reward-value coupled with an underdeveloped inhibitory control, and thus a hypersensitivity to reward. Perturbations during adolescence can alter the developmental trajectory of the brain, resulting in long-term alterations in reward-associated behaviors...
November 8, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29110162/recent-advances-in-the-pharmacological-management-of-gastroesophageal-reflux-disease
#14
REVIEW
Yu-Min Kung, Wen-Hung Hsu, Meng-Chieh Wu, Jiunn-Wei Wang, Chung-Jung Liu, Yu-Chung Su, Chao-Hung Kuo, Fu-Chen Kuo, Deng-Chyang Wu, Yao-Kuang Wang
The management of proton pump inhibitor-refractory GERD (rGERD) is a challenge in clinical practice. Since up to one-third of patients with typical GERD symptoms (heartburn and/or acid regurgitation) are not satisfied with proton pump inhibitor (PPI) therapy, new drug development targeting different pathophysiologies of GERD is imperative. At present, no other drugs serve as a more potent acid suppression agent than PPIs. As an add-on therapy, histamine type-2 receptor antagonists, alginates, prokinetics and transient lower esophageal sphincter relaxation inhibitors have some impact on the subgroups of rGERD, but greater effectiveness and fewer adverse effects for widespread use are required...
December 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29106277/dark-and-vulnerable-personality-trait-correlates-of-dimensions-of-criminal-behavior-among-adult-offenders
#15
Bethany G Edwards, Emily Albertson, Edelyn Verona
Given the high-level impact of crime, empirical work is needed to identify personality traits, or overarching factors of personality pathology, that may leave individuals more prone to engage in criminal behaviors. This study empirically tested the distinction between the dark personality and vulnerable dark personality spectra (Miller et al., 2010) in a large offender sample and aimed to test how these personality factors relate to criminal dimensions and individual types of crime. Self-report and public record data verified criminal behaviors for 493 (34...
October 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/29106000/delayed-type-hypersensitivity-to-oral-and-parenteral-drugs
#16
Oliver Brandt, Andreas J Bircher
Adverse drug reactions of the delayed type rank among the most common dermatoses and are predominantly characterized by exanthematous macular or maculopapular eruptions. However, approximately 2 % of affected individuals develop severe or even life-threatening systemic immune reactions associated with organ involvement, requiring immediate diagnosis and treatment. Numerous drugs are capable of eliciting delayed-type hypersensitivity reactions, with antibiotics, anticonvulsant drugs, and the xanthine oxidase inhibitor allopurinol being the most common...
November 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29105793/what-can-we-learn-in-drug-allergy-management-from-world-health-organization-s-international-classifications
#17
REVIEW
Luciana Kase Tanno, Maria Jose Torres, Mariana Castells, Pascal Demoly
Drug hypersensitivity reactions (DHRs) represent growing health problem worldwide, affecting more than 7% of the general population and represent an important public health problem. However, knowledge in DHRs morbidity and mortality epidemiological data is still not optimal and international comparable standards remain poorly accessed. Institutional databases worldwide increasingly use the WHO International Classification of Diseases (ICD) system to classify diagnoses, health services utilization and death data...
November 6, 2017: Allergy
https://www.readbyqxmd.com/read/29105525/pegasparaginase-silent-inactivation-during-therapy-for-nk-t-cell-lymphoma
#18
Deeter R Neumann, Bernard L Marini, Tycel J Phillips, Ryan A Wilcox, Tera L Mayer, Anna Brown, Anthony J Perissinotti
Natural Killer/T cell (NK/T cell) lymphoma is a rare, yet aggressive T cell lymphoma, which often displays resistance to traditional chemotherapies. Asparagainse (ASNase), through its unique mechanism of action, has become a vital component in the treatment of NK/T cell lymphoma. However, because ASNase is of bacterial origin, antibody formation can render the therapy ineffective, even in the absence of clinical hypersensitivity, which has been coined 'silent inactivation.' While the phenomenon of silent inactivation of PEG-ASNase is well documented in the treatment of ALL, it has not been described in NK/T cell lymphoma patients...
November 6, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29103822/ziprasidone-a-second-generation-antipsychotic-drug-triggers-a-macrophage-inflammatory-response-in-vitro
#19
Thiago Duarte, Fernanda Barbisan, Pedro Antônio Schmidt do Prado-Lima, Verônica Farina Azzolin, Ivo Emílio da Cruz Jung, Marta Maria Medeiros Frescura Duarte, Cibele Ferreira Teixeira, Moises Henrique Mastella, Ivana Beatrice Mânica da Cruz
Antipsychotic drugs are used to treat schizophrenia and other psychiatric disorders. However, most of these drugs present side effects causing obesity and other serious metabolic alterations that correlate with grade of chronic inflammation. In contrast, ziprasidone's (ZIP) metabolic side effects are attenuated relative to those of other antipsychotic drugs, but some reports suggest that this drug could cause allergic, hypersensitive reactions in susceptible patients. At present, the mechanism of ZIP's effect on peripheral inflammatory metabolism is not well characterized...
November 2, 2017: Cytokine
https://www.readbyqxmd.com/read/29103257/-fever-hepatic-dysfunction-and-interstitial-pneumonia-caused-by-intravesical-bacillus-calmette-guerin-bcg-instillation-after-urethral-bougie-a-case-report
#20
Satoshi Nitta, Shotaro Sakka, Tsuyoshi Endo, Manabu Komine, Masakazu Tsutsumi, Hiroyuki Nishiyama
A 60-year-old man had a past history of urothelial carcinoma of the left renal pelvis treated with laparoscopic left total nephroureterectomy in October 2004. He underwent transurethral resection of the bladder tumor (TUR-Bt) twice for recurrence of urothelial carcinoma in the bladder in April 2014 and February 2015, and subsequently received intravesical Bacillus Calmette-Guerin (BCG) instillation at weekly intervalsfor prevention of recurrence. In November 2016, a year and a half after BCG induction, he received BCG therapy after urethral bougie to dilate the urethral stricture...
October 2017: Hinyokika Kiyo. Acta Urologica Japonica
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