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https://www.readbyqxmd.com/read/29444872/fviii-proteins-with-a-modified-immunodominant-t-cell-epitope-exhibit-reduced-immunogenicity-and-normal-fviii-activity
#1
Ruth A Ettinger, Joseph A Liberman, Devi Gunasekera, Komal Puranik, Eddie A James, Arthur R Thompson, Kathleen P Pratt
Factor VIII (FVIII)-neutralizing antibodies (inhibitors) are a serious complication in hemophilia A (HA). The peptide FVIII 2194-2213 contains an immunodominant HLA-DRA*01-DRB1*01:01 (DRB1*01:01)-restricted epitope recognized by CD4 + T-effector cells from HA subjects. The aim of this study was to identify amino acid substitutions to deimmunize this epitope while retaining procoagulant function and expression levels comparable to those of wild-type (WT) FVIII proteins. The shortest DRB1*01:01-binding peptide was FVIII 2194-2205 , and residues important for affinity were identified as F2196, M2199, A2201, and S2204...
February 27, 2018: Blood Advances
https://www.readbyqxmd.com/read/29429495/selecting-effective-intervention-strategies-for-escape-maintained-academic-performance-problems-consider-giving-em-a-break
#2
Maureen A O'Connor, Edward J Daly
This study compared consequence-and antecedent-based strategies to determine which treatments or combination of treatments produced the strongest improvements in math computation fluency with four elementary-aged students whose math computation was under the control of an escape contingency. Functional analyses were conducted to identify elementary-school students whose academic responding was under a negative-reinforcement contingency. A multielement design was then used to examine the impact of four treatments (DNRA, DRA, task choice, and task choice plus DRA) on each student's rate of correct digits per min...
February 2018: Journal of School Psychology
https://www.readbyqxmd.com/read/29417945/emodin-alleviates-alternatively-activated-macrophage-and-asthmatic-airway-inflammation-in-a-murine-asthma-model
#3
Yun-Duan Song, Xiao-Zong Li, Ya-Xian Wu, Yao Shen, Fang-Fang Liu, Pei-Pei Gao, Lei Sun, Feng Qian
Alternatively activated macrophages (AAMs) are not only associated with asthma but also lead to asthmatic airway inflammation and remodeling. Inhibition of AAMs is an alternative therapeutic strategy for treating asthma. In this study we investigated whether emodin (1,3,8-trihydroxy-6-methylanthraquinone), isolated from the rhizome of Rheum palmatum, alleviated asthmatic airway inflammation and reduced AAM polarization in a murine asthma model. Mice were sensitized with a triple allergen mix containing dust mite, ragweed and aspergillus (DRA)...
February 8, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29390175/amine-induced-retardation-of-the-radical-mediated-thiol-ene-reaction-via-the-formation-of-metastable-disulfide-radical-anions
#4
Dillon Marshall Love, Kangmin Kim, John Taylor Goodrich, Benjamin D Fairbanks, Brady T Worrell, Mark P Stoykovich, Charles B Musgrave, Christopher N Bowman
The effect of amines on the kinetics and efficacy of radical-mediated thiol-ene coupling (TEC) reactions was investigated. By varying the thiol reactant and amine additive, it was shown that amines retard thiyl radical-mediated reactions when the amine is adequately basic enough to deprotonate the thiol affording the thiolate anion. E.g. when the weakly basic amine tetramethylethylenediamine was incorporated in the TEC reaction between butyl 2-mercaptoacetate and an allyl ether at 5 mol%, the final conversion was reduced from quantitative to < 40%...
February 1, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29385456/dietary-supplements-during-the-cold-season-increase-rumen-microbial-abundance-and-improve-rumen-epithelium-development-in-tibetan-sheep
#5
X P Jing, Q H Peng, R Hu, H W Zou, H Z Wang, X Q Yu, J W Zhou, A A Degen, Z S Wang
Livestock on the Qinghai-Tibetan Plateau are faced with extreme harsh winters and are often in negative energy balance during this period. Dietary supplementation can improve growth performance of Tibetan sheep and, consequently, we hypothesized that it would also increase microbial abundance and rumen epithelium development. To test this hypothesis, we examined the effect of feed supplementation during the cold season on rumen microbes, fermentation, epithelium development and absorptive capability in Tibetan sheep...
January 27, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29330471/slc26a3-dra-prevents-tnf-alpha-induced-barrier-dysfunction-and-dextran-sulfate-sodium-induced-acute-colitis
#6
Xiangming Ding, Dongxiao Li, Mengke Li, Han Wang, Qin He, Yunwu Wang, Hongbing Yu, Dean Tian, Qin Yu
SLC26A3 encodes a Cl-/HCO3- ion transporter that is also known as downregulated in adenoma (DRA) and is involved in HCO3-/mucus formation. The role of DRA in the epithelial barrier has not been previously established. In this study, we investigated the in vivo and in vitro mechanisms of DRA in the colon epithelial barrier. Immunofluorescence (IF) and co-immunoprecipitation (co-IP) studies reveal that DRA binds directly to tight junction (TJ) proteins and affects the expression of TJ proteins in polarized Caco-2BBe cells...
January 12, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29317492/a-protein-interaction-network-centered-on-leucine-rich-repeats-and-immunoglobulin-like-domains-1-lrig1-regulates-growth-factor-receptors
#7
Mahmood Faraz, Carl Herdenberg, Camilla Holmlund, Roger Henriksson, Håkan Hedman
Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is a tumor suppressor and a negative regulator of several receptor tyrosine kinases (RTKs). The molecular mechanisms by which LRIG1 mediates its tumor suppressor effects and regulates RTKs remain incompletely understood. Here, we performed a yeast two-hybrid screen to identify novel LRIG1-interacting proteins and mined data from the BioPlex (biophysical interactions of ORFeome-based complexes) protein interaction data repository. The putative LRIG1 interactors identified in the screen were functionally evaluated using a triple co-transfection system in which HEK293 cells were co-transfected with platelet-derived growth factor receptor alpha (PDGFRA), LRIG1, and shRNAs against the identified LRIG1 interactors...
January 9, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29305650/a-look-at-the-smelly-side-of-physiology-transport-of-short-chain-fatty-acids
#8
REVIEW
Friederike Stumpff
Fermentative organs such as the caecum, the colon, and the rumen have evolved to produce and absorb energy rich short chain fatty acids (SCFA) from otherwise indigestible substrates. Classical models postulate diffusional uptake of the undissociated acid (HSCFA). However, in net terms, a major part of SCFA absorption occurs with uptake of Na+ and resembles classical, coupled electroneutral NaCl transport. Considerable evidence suggests that the anion transporting proteins expressed by epithelia of fermentative organs are poorly selective and that their main function may be to transport acetate-, propionate-, butyrate- and HCO3- as the physiologically relevant anions...
January 6, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29286110/tumor-necrosis-factor-%C3%AE-acts-reciprocally-with-solute-carrier-family-26-member-3-downregulated-in-adenoma-and-reduces-its-expression-leading-to-intestinal-inflammation
#9
Xiangming Ding, Dongxiao Li, Mengke Li, Dean Tian, Hongbing Yu, Qin Yu
Solute carrier family 26, member 3 (Slc26a3), also termed downregulated-in-adenoma (DRA) is a member of the Slc26 family of anion transporters and is mutated in congenital chloride diarrhea. Our previous study demonstrated that DRA deficiency is associated with severely reduced colonic HCO3‑ secretion, a loss of colonic fluid absorption, a lack of a firmly adherent mucus layer and a severely reduced colonic mucosal resistance to dextran sodium sulfate (DSS) damage. However, the direct effect of mediators that trigger intestinal inflammatory factors on DRA has not been fully investigated...
December 22, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29285385/mhc-class-ii-associated-stomach-cancer-mutations-correlate-with-lack-of-subsequent-tumor-development
#10
John M Yavorski, George Blanck
The role of tumor cell expression of major histocompatibility class II (MHCII) has been controversial, with evidence indicating that tumor cell expression of MHCII may lead to an anti-tumor immune response and to tumor cell apoptosis and that MHCII has pro-tumorigenic functions. The cancer genome atlas (TCGA) indicates numerous deleterious mutations for the highly specific, MHCII transcriptional activation proteins, RFX5, RFXAP, RFXANK and CIITA. Also, mutations in the non-polymorphic, human leukocyte antigen (HLA)-DRA gene, which encodes the heavy chain for the most prominent human MHCII molecule, HLA-DR, are common...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29283466/improved-segmental-myocardial-strain-reproducibility-using-deformable-registration-algorithms-compared-with-feature-tracking-cardiac-mri-and-speckle-tracking-echocardiography
#11
Jie Wang, Weihao Li, Jiayu Sun, Hong Liu, Yu Kang, Dan Yang, Liuyu Yu, Andreas Greiser, Xiaoyue Zhou, Yuchi Han, Yucheng Chen
BACKGROUND: Segmental myocardial strain using feature tracking (FT) cardiac MRI is not acceptable due to poor reproducibility. PURPOSE: To assess the reproducibility of left ventricle (LV) segmental myocardial strain measured by deformation registration algorithm (DRA). STUDY TYPE: Prospective clinical trial. SUBJECTS: Sixteen healthy volunteers and 28 hypertrophic cardiomyopathy (HCM) patients. FIELD STRENGTH/SEQUENCE: Retrospective ECG gating cardiac MRI imaging was performed at 3...
December 28, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29228344/relationship-between-inter-rectus-distance-and-symptom-severity-in-women-with-diastasis-recti-in-the-early-postpartum-period
#12
Nadia Keshwani, Sunita Mathur, Linda McLean
Background: Diastasis recti abdominis (DrA) is associated with negative body image, musculoskeletal pain and dysfunction, and perhaps urogynecological complaints. The severity of DrA has traditionally been determined by measuring the inter-rectus distance (IRD); however, the relationship between IRD and symptoms in women with DrA is unclear. Objective: The objective of the study was to investigate the relationship between IRD and symptom severity in women with DrA in the early postpartum period...
December 4, 2017: Physical Therapy
https://www.readbyqxmd.com/read/29205337/prevention-of-the-development-of-problem-behavior-a-laboratory-model
#13
Tara A Fahmie, Anne C Macaskill, Ellie Kazemi, Uilani C Elmer
Few studies have isolated the preventive efficacy of common behavioral strategies like noncontingent reinforcement (NCR) and differential reinforcement of alternative behavior (DRA). The purpose of the current study was to develop and evaluate a laboratory model of these two problem behavior prevention strategies. Undergraduate students participated in a computer simulation, in which clicks to a designated area of the computer screen were analogous to the emergence of problem behavior. The responding of participants in a control group, who experienced a percentile schedule used to mimic the shaping of problem behavior, was compared to that of participants in two experimental groups, each with a history of either DRA or NCR...
December 4, 2017: Journal of Applied Behavior Analysis
https://www.readbyqxmd.com/read/29201661/occurrence-of-clostridium-perfringens-in-sausages-sold-in-meknes-city-morocco
#14
Abdelaziz Ed-Dra, Fouzia Rhazi Filali, Abdellah El Allaoui, Anis Sfendla
In Morocco, the consumption of meat products has experienced a sharp increase in recent years despite the presence of pathogenic bacteria due to hygiene failure. The present study was designed to determine the prevalence of Clostridium perfringens in sausages sold in Meknes city (Morocco) and to study the different factors affecting it contamination with this bacterium. To this end, 156 samples of sausages were taken in various shopping sites during one year from March 2014 to February 2015. The microbiological analysis was carried out using the specific medium for isolation and identification of C...
2017: Open Veterinary Journal
https://www.readbyqxmd.com/read/29199960/update-on-the-genetic-basis-of-drug-hypersensitivity-reactions
#15
REVIEW
R Jurado-Escobar, J R Perkins, E García-Martín, M Isidoro-García, I Doña, M J Torres, J A Cornejo-García
Drug hypersensitivity reactions (DHRs) are unpredictable, complex responses to medicines in predisposed individuals. They represent a major health problem owing to the number of patients affected and the severity of the clinical conditions they can induce. In addition to environmental factors, the underlying mechanisms of DHRs are also influenced by genetic factors, although considerable gaps remain in our knowledge. Therefore, further study of the genetics of DHRs is necessary to shed light on their underlying mechanisms...
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29195217/effects-of-posture-and-anatomical-location-on-inter-recti-distance-measured-using-ultrasound-imaging-in-parous-women
#16
S Gillard, C G Ryan, M Stokes, M Warner, J Dixon
STUDY DESIGN: Cross-sectional repeated measures. OBJECTIVES: To quantify the effects of posture and measurement site on the inter-recti distance (IRD) and investigate the reliability of IRD measurement using ultrasound imaging in different postures. BACKGROUND: The linea alba connects the rectus abdominis muscles anteriorly and the width is known as the IRD. The IRD is usually measured in crook-lying and is the primary outcome measure to assess for a divarication of recti abdominis (DRA)...
November 22, 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/29156840/association-between-cyp2e1-genetic-polymorphisms-and-urinary-cancer-risk-a-meta-analysis
#17
Zhiqing Fang, Yun Wu, Ning Zhang
Objective: Studies investigating the contribution of Cytochrome P4502E1 (CYP2E1) polymorphisms to the etiology of urinary cancer draw inconsistent conclusions. Thus, we performed a meta-analysis to evaluate the association between CYP2E1 Rsa I/Pst I and Dra I polymorphisms and urinary cancer susceptibility. Materials and Methods: Meta-analysis based on the eligible case-control studies that assess the association of CYP2E1 Rsa I/Pst I and Dra I polymorphisms with urinary cancer was conducted...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29104321/the-role-of-contingencies-and-stimuli-in-a-human-laboratory-model-of-treatment-of-problem-behavior
#18
William V Dube, Brooks Thompson, Marcelo V Silveira, John A Nevin
Behavioral momentum theory posits a paradoxical implication for behavioral interventions in clinical situations using Differential Reinforcement of Alternative Behavior (DRA): When alternative reinforcers are presented within the same context as the problem behavior, the added reinforcers may decrease the frequency of the behavior but also increase its persistence when the intervention ends. Providing alternative reinforcers in a setting that is distinctively different from that in which the target behavior occurs may avoid or reduce this increase in persistence...
December 2017: Psychological Record
https://www.readbyqxmd.com/read/29093719/interaction-of-thp-1-monocytes-with-conidia-and-hyphae-of-different-curvularia-strains
#19
Eszter Judit Tóth, Éva Boros, Alexandra Hoffmann, Csilla Szebenyi, Mónika Homa, Gábor Nagy, Csaba Vágvölgyi, István Nagy, Tamás Papp
Interaction of the human monocytic cell line, THP-1 with clinical isolates of three Curvularia species were examined. Members of this filamentous fungal genus can cause deep mycoses emerging in both immunocompromised and immunocompetent patients. It was found that monocytes reacted only to the hyphal form of Curvularia lunata. Cells attached to the germ tubes and hyphae and production of elevated levels of interleukin (IL)-8 and IL-10 and a low level of TNF-α were measured. At the same time, monocytes failed to produce IL-6...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29055777/characterization-of-classical-major-histocompatibility-complex-mhc-class-ii-genes-in-northern-pig-tailed-macaques-macaca-leonina
#20
Xiao-Dong Lian, Xi-He Zhang, Zheng-Xi Dai, Yong-Tang Zheng
The northern pig-tailed macaque (Macaca leonina) has been identified as an independent species from the pig-tailed macaque group. The species is a promising animal model for HIV/AIDS pathogenesis and vaccine studies due to susceptibility to HIV-1. However, the major histocompatibility complex (MHC) genetics in northern pig-tailed macaques remains poorly understood. We have previously studied the MHC class I genes in northern pig-tailed macaques and identified 39 novel alleles. Here, we describe the MHC class II alleles in all six classical loci (DPA, DPB, DQA, DQB, DRA, and DRB) from northern pig-tailed macaques using a sequence-based typing method for the first time...
October 18, 2017: Infection, Genetics and Evolution
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