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Ke Wan, Jiayu Sun, Dan Yang, Hong Liu, Jie Wang, Wei Cheng, Qing Zhang, Zhi Zeng, Tianjing Zhang, Andreas Greiser, Marie-Pierre Jolly, Yuchi Han, Yucheng Chen
Purpose To measure left ventricular (LV) myocardial strain with cine magnetic resonance (MR) imaging and a deformable registration algorithm (DRA) and to assess the prognostic value of myocardial strain in patients with light-chain (AL) amyloidosis. Materials and Methods In this prospective study, 78 consecutive patients with AL amyloidosis who underwent contrast material-enhanced cardiac MR imaging were enrolled at West China Hospital. LV myocardial strains and late gadolinium enhancement (LGE) were evaluated...
April 17, 2018: Radiology
Mailin Adriana Villán-Villán, Rodrigo Pérez-Rodríguez, Cristina Martín, Patricia Sánchez-González, Ignasi Soriano, Eloy Opisso, Dra M Elena Hernando, José María Tormos, Josep Medina, Enrique J Gómez
BACKGROUND: The increasing number of patients with acquired brain injury and the current subjectivity of the conventional upper extremity (UE) assessment tests require new objective assessment techniques. OBJECTIVE: This research proposes a novel objective motor assessment (OMA) methodology based on the Fugl-Meyer assessment (FMA). The goals are to automatically calculate the objective scores (OSs) of FMA-UE movements (as well as a global OS) and to interpret the estimated OSs...
April 7, 2018: NeuroRehabilitation
Sławomir Kujawski, Agnieszka Kujawska, Małgorzata Gajos, Jacek J Klawe, Małgorzata Tafil-Klawe, Katarzyna Mądra-Gackowska, Błażej Stankiewicz, Julia L Newton, Kornelia Kędziora-Kornatowska, Paweł Zalewski
BACKGROUND: Arterial stiffness (AS) is a reduction in the ability of large arteries to readily accommodate the increase in blood ejected from the heart during systole related with aging. Physical exercise is associated with AS reduction. However, it remains controversial as to which modality and intensity (resistance vs aerobic, high vs low) would be the most effective. The aim of these studies is to examine the effects of 3-months sitting callisthenic balance (SCB) and resistance exercise (RET) on aerobic capacity, aortic stiffness and body composition in older participants...
April 12, 2018: Experimental Gerontology
Tanja Heinloth, Juliane Uhlhorn, Mathias F Wernet
The e-vector orientation of linearly polarized light represents an important visual stimulus for many insects. Especially the detection of polarized skylight by many navigating insect species is known to improve their orientation skills. While great progress has been made towards describing both the anatomy and function of neural circuit elements mediating behaviors related to navigation, relatively little is known about how insects perceive non-celestial polarized light stimuli, like reflections off water, leaves, or shiny body surfaces...
2018: Frontiers in Cellular Neuroscience
Hayley P Coffing, Shubha Priyamvada, Arivarasu Natarajan Anbazhagan, Christine Salibay, Melinda A Engevik, James Versalovic, Mary Beth Yacyshyn, Bruce R Yacyshyn, Sangeeta Tyagi, Seema Saksena, Ravinder K Gill, Waddah A Alrefai, Pradeep K Dudeja
Clostridium difficile infection is the primary cause of nosocomial diarrhea in the United States. While C. difficile toxins A and B are the primary mediators of CDI, the overall pathophysiology underlying C. difficile associated diarrhea remains poorly understood. Studies have shown that both NHE3 (Na+ /H+ exchanger) and DRA (Down Regulated in Adenoma, Cl- /HCO3 - exchanger) resulting in decreased electrolyte absorption are implicated in infectious and inflammatory diarrhea. Furthermore, studies have shown that NHE3 is depleted at the apical surface of intestinal epithelial cells and down-regulated in patients with CDI, but the role of DRA in C...
March 29, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
E M Sion, P Godon
A comparison is presented between the physical processes operative in single white dwarfs and the physical processes operative in white dwarfs with donor star companions. The physical properties and accretion physics of the hot accreting components in close interacting binaries is presented. The N/C abundance anomaly seen is ∼10% of cataclysmic variables and the presence of absorption lines due to heavy elements in suprasolar abundance are discussed. A synthetic spectral analysis of the FUSE spectrum of the old nova RR Pic reveals reveals an accretion disk with i = 60°, M wd = 1...
2018: PoS, proceedings of science
Bishnu P Subedi, Paul F Fitzpatrick
Solution studies of the aromatic amino acid hydroxylases are consistent with the FeIVO intermediate not forming until both the amino acid and tetrahydropterin substrates have bound. Structural studies have shown that the positions of active-site loops differs significantly between the free enzyme and the enzyme-amino acid-tetrahydropterin complex. In tryptophan hydroxylase (TrpH) these mobile loops contain residues 124-134 and 365-371, with a key interaction involving Ile366. The I366N mutation in TrpH results in decreases of 1-2 orders of magnitude in the kcat and kcat/Km values...
March 28, 2018: Journal of the American Chemical Society
Sebastian Boegel, Martin Löwer, Thomas Bukur, Patrick Sorn, John C Castle, Ugur Sahin
BACKGROUND: The presentation of HLA peptide complexes to T cells is a highly regulated and tissue specific process involving multiple transcriptionally controlled cellular components. The extensive polymorphism of HLA genes and the complex composition of the proteasome make it difficult to map their expression profiles across tissues. METHODS: Here we applied a tailored gene quantification pipeline to 4323 publicly available RNA-Seq datasets representing 55 normal tissues and cell types to examine expression profiles of (classical and non-classical) HLA class I, class II and proteasomal genes...
March 27, 2018: BMC Medical Genomics
Li Han, Mei-Hong Cheng, Min Zhang, Kai Cheng
Objective: The objective of this paper was to investigate key genes in retinoblastoma using a novel method which is mainly based on five kinds of genes, differentially expressed genes (DEGs), differential pathway genes (DPGs), seed genes (common genes between DEGs and DPGs), hub genes and informative genes (common genes of hub genes and DEGs), and support vector machines (SVM) model. Materials and Methods: In the proposed method, the first step was to identify five types of significant genes...
2018: Journal of Cancer Research and Therapeutics
Thomas Volz, Susanne Kaesler, Christian Draing, Thomas Hartung, Martin Röcken, Yuliya Skabytska, Tilo Biedermann
BACKGROUND: Staphylococcus epidermidis colonizes human skin without apparent inflammation, but a dominance of S. epidermidis and S. aureus is characteristic of cutaneous microbial dysbiosis in atopic dermatitis (AD). While S. aureus can trigger AD, the role of S. epidermidis is less understood. METHODS: We characterized consequences of innate immune sensing of lipoteichoic acid (LTA) preparations derived from S. epidermidis (epi-LTA) or S. aureus (aureus-LTA). Therefore, dendritic cell (DC) activation and consecutive priming of antigen-specific T cells following exposure of DC to epi-LTA or aureus-LTA were investigated...
March 23, 2018: Experimental Dermatology
Agata Michalska, Wojciech Rokita, Daniel Wolder, Justyna Pogorzelska, Krzysztof Kaczmarczyk
Diastasis recti abdominis is a condition in which both rectus abdominis muscles disintegrate to the sides, this being ac-companied by the extension of the linea alba tissue and bulging of the abdominal wall. DRA may result in the herniation of the abdominal viscera, but it is not a hernia per se. DRA is common in the female population during pregnancy and in the postpartum period. There is a scant knowledge on the prevalence, risk factors, prevention or management of the abovemen-tioned condition. The aim of this paper is to present the methods of DRA treatment based on the results of recent studies...
2018: Ginekologia Polska
Kotaro Matsumoto, Jun Kikuchi, Yuko Kaneko, Hidekata Yasuoka, Kazuko Suzuki, Hirobumi Tokuyama, Kaori Kameyama, Kunihiro Yamaoka, Tsutomu Takeuchi
RATIONALE: Dialysis-related amyloidosis (DRA) can present rheumatic manifestations in patients on long-term hemodialysis. Typical articular symptoms with DRA involve carpal-tunnel syndrome, effusion in large joints, spondyloarthropathy, or cystic bone lesions, which are usually with non-inflammatory processes. PATIENT CONCERNS: A 64-year-old man on hemodialysis for >30 years was admitted because of intermittent fever, polyarthritis, and elevated serum C-reactive protein (CRP) level, which was continuous for 2 years...
January 2018: Medicine (Baltimore)
Olabola Awosika, Elias Oussedik
Rosacea is a common inflammatory skin disease with a multifaceted pathophysiology, including environmental stressors and neurovascular and immune dysfunction affected by the presence of pathogens. The genetic component of this disorder is not well understood. However, a possible genetic origin in Northern European descendants, family inheritance, twin concordance, and genetic associations with autoimmune disorders attest the genetic predisposition to rosacea. Currently, one single-nucleotide polymorphism has been identified in association with rosacea and is intergenic between HLA-DRA and BTNL2...
April 2018: Dermatologic Clinics
S Shanun Kunnavatana, Sarah E Bloom, Andrew L Samaha, Timothy A Slocum, Casey J Clay
Differential reinforcement of alternative behavior (DRA) most often includes extinction as a treatment component. However, extinction is not always feasible and it can be counter-therapeutic if implemented without optimal treatment integrity. Researchers have successfully implemented DRA without extinction by manipulating various parameters of reinforcement such that alternative behavior is favored. We extended previous research by assessing three participants' sensitivities to quality, magnitude, and immediacy using arbitrary responses and reinforcers that maintain problem behavior...
February 23, 2018: Journal of Applied Behavior Analysis
Hanae Naceiri Mrabti, Karima Sayah, Nidal Jaradat, Faouzi Kichou, Abdelaziz Ed-Dra, Badiaa Belarj, Yahia Cherrah, My El Abbes Faouzi
Background Diabetes mellitus (DM) is currently a major health problem and the most common chronic disease worldwide. Traditional medicinal plants remedies remain a potential adjunct therapy to maintain better glycemic control while also imparting few side-effects. Arbutus unedo L. has been traditionally used to manage several diseases including diabetes. This study was undertaken to contribute the validation of the traditional use of Arbutus unedoL. (Ericaceae) in the treatment of diabetes. Methods In-vitro antidiabetic effect of the A...
February 21, 2018: Journal of Complementary & Integrative Medicine
Edward M Sion, Patrick Godon, Joanna Mikolajewska, Bassem Sabra, Craig Kolobow
We have conducted a spectroscopic analysis of the far ultraviolet archival spectra of four symbiotic variables, EG And, AE Ara, CQ Dra and RW Hya. RW Hya and EG And have never had a recorded outburst while CQ Dra and AE Ara have outburst histories. We analyze these systems while they are in quiescence in order to help reveal the physical properties of their hot components via comparisons of the observations with optically thick accretion disk models and NLTE model white dwarf photospheres. We have extended the wavelength coverage down to the Lyman Limit with FUSE spectra...
April 2017: Astronomical Journal
Ruth A Ettinger, Joseph A Liberman, Devi Gunasekera, Komal Puranik, Eddie A James, Arthur R Thompson, Kathleen P Pratt
Factor VIII (FVIII)-neutralizing antibodies (inhibitors) are a serious complication in hemophilia A (HA). The peptide FVIII 2194-2213 contains an immunodominant HLA-DRA*01-DRB1*01:01 (DRB1*01:01)-restricted epitope recognized by CD4 + T-effector cells from HA subjects. The aim of this study was to identify amino acid substitutions to deimmunize this epitope while retaining procoagulant function and expression levels comparable to those of wild-type (WT) FVIII proteins. The shortest DRB1*01:01-binding peptide was FVIII 2194-2205 , and residues important for affinity were identified as F2196, M2199, A2201, and S2204...
February 27, 2018: Blood Advances
Maureen A O'Connor, Edward J Daly
This study compared consequence-and antecedent-based strategies to determine which treatments or combination of treatments produced the strongest improvements in math computation fluency with four elementary-aged students whose math computation was under the control of an escape contingency. Functional analyses were conducted to identify elementary-school students whose academic responding was under a negative-reinforcement contingency. A multielement design was then used to examine the impact of four treatments (DNRA, DRA, task choice, and task choice plus DRA) on each student's rate of correct digits per min...
February 2018: Journal of School Psychology
Yun-Duan Song, Xiao-Zong Li, Ya-Xian Wu, Yao Shen, Fang-Fang Liu, Pei-Pei Gao, Lei Sun, Feng Qian
Alternatively activated macrophages (AAMs) are not only associated with asthma but also lead to asthmatic airway inflammation and remodeling. Inhibition of AAMs is an alternative therapeutic strategy for treating asthma. In this study we investigated whether emodin (1,3,8-trihydroxy-6-methylanthraquinone), isolated from the rhizome of Rheum palmatum, alleviated asthmatic airway inflammation and reduced AAM polarization in a murine asthma model. Mice were sensitized with a triple allergen mix containing dust mite, ragweed and aspergillus (DRA)...
February 8, 2018: Acta Pharmacologica Sinica
Dillon Marshall Love, Kangmin Kim, John Taylor Goodrich, Benjamin D Fairbanks, Brady T Worrell, Mark P Stoykovich, Charles B Musgrave, Christopher N Bowman
The effect of amines on the kinetics and efficacy of radical-mediated thiol-ene coupling (TEC) reactions was investigated. By varying the thiol reactant and amine additive, it was shown that amines retard thiyl radical-mediated reactions when the amine is adequately basic enough to deprotonate the thiol affording the thiolate anion. E.g. when the weakly basic amine tetramethylethylenediamine was incorporated in the TEC reaction between butyl 2-mercaptoacetate and an allyl ether at 5 mol%, the final conversion was reduced from quantitative to < 40%...
February 1, 2018: Journal of Organic Chemistry
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