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https://www.readbyqxmd.com/read/27847319/transcriptional-profiles-of-type-2-diabetes-in-human-skeletal-muscle-reveal-insulin-resistance-metabolic-defects-apoptosis-and-molecular-signatures-of-immune-activation-in-response-to-infections
#1
Chun Wu, Gang Xu, Shang-Yi A Tsai, William J Freed, Chun-Ting Lee
Skeletal muscle insulin resistance is considered to be the primary defect involved in type 2 diabetes mellitus (T2DM). Despite transcriptome studies in limited T2DM human subjects suggesting an association of T2DM with impaired oxidative phosphorylation in muscle, its molecular pathogenesis remains largely unknown. To identify dysregulated genes and gene networks that are associated with T2DM in human skeletal muscle, we examined expression patterns of 56,318 transcribed genes on 92 T2DM cases and 184 gender-, age- and race-matched non-diabetic controls from the Genotype-Tissue Expression (GTEx) database...
November 12, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27779086/genetic-predictors-of-drug-hypersensitivity
#2
José A Cornejo-García, Abderrahim Oussalah, Miguel Blanca, Rosa-María Guéant-Rodríguez, Cristobalina Mayorga, Julie Waton, Annick Barbaud, Francesco Gaeta, Antonino Romano, Jean-Louis Guéant
Our knowledge of genetic predisposing factors of drug hypersensitivity reactions (DHRs) is still scarce. The analysis of the genetic basis of these reactions may contribute to dissect the underlying mechanisms. We will outline current knowledge of the genetic predictors of most common DHRs, including reactions to betalactam antibiotics (BLs), nonsteroidal anti-inflammatory drugs (NSAIDs) and biological agents. The predictors of DHRs to BLs are mostly linked to IgE-class switching, IgE pathway and atopy (IL4R, NOD2, LGALS3) in replicated candidate gene studies, and to antigen presentation (HLA-DRA) in the single replicated GWAS performed so far...
September 27, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27774056/microglomerular-synaptic-complexes-in-the-sky-compass-network-of-the-honeybee-connect-parallel-pathways-from-the-anterior-optic-tubercle-to-the-central-complex
#3
Martina Held, Annuska Berz, Ronja Hensgen, Thomas S Muenz, Christina Scholl, Wolfgang Rössler, Uwe Homberg, Keram Pfeiffer
While the ability of honeybees to navigate relying on sky-compass information has been investigated in a large number of behavioral studies, the underlying neuronal system has so far received less attention. The sky-compass pathway has recently been described from its input region, the dorsal rim area (DRA) of the compound eye, to the anterior optic tubercle (AOTU). The aim of this study is to reveal the connection from the AOTU to the central complex (CX). For this purpose, we investigated the anatomy of large microglomerular synaptic complexes in the medial and lateral bulbs (MBUs/LBUs) of the lateral complex (LX)...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27744694/development-of-a-model-immunoassay-utilizing-monoclonal-antibodies-of-different-specificities-for-quantitative-determination-of-dieldrin-and-heptachlors-in-their-mixtures
#4
Chiwa Kataoka, Masumi Nihei, Masaomi Nimata, Kazuyuki Sawadaishi
The presence of dieldrin and heptachlor residues in cucurbitaceous crops at concentrations exceeding the limits set by the Japanese Food Sanitation Law constitutes a serious problem. To prevent accumulation of these residues in cucurbitaceous crops, development of high-throughput analysis methods for the detection of contaminants in the soil before cultivation is required. In this study, we aimed to develop a model immunoassay using new monoclonal antibodies (MAbs) to quantitatively determine dieldrin and heptachlor contents in their mixtures...
October 17, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27709104/positive-feedback-cycle-of-tnf%C3%AE-promotes-staphylococcal-enterotoxin-b-induced-thp-1-cell-apoptosis
#5
Xiaopeng Zhang, Weilong Shang, Jizhen Yuan, Zhen Hu, Huagang Peng, Junmin Zhu, Qiwen Hu, Yi Yang, Hui Liu, Bei Jiang, Yinan Wang, Shu Li, Xiaomei Hu, Xiancai Rao
Staphylococcal enterotoxin B (SEB) has been demonstrated to be of importance in Staphylococcus aureus related diseases, such as atopic dermatitis (AD). Dysregulated apoptosis in AD is remarkable, and SEB can induce apoptosis of various cell types. However, the mechanisms by which SEB induces apoptosis and influences disease processes remain unclear. In this study, the recombinant SEB-induced THP-1 monocyte apoptosis was demonstrated in the absence of preliminary cell activation in a time- and dose-dependent manner...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27699233/t-cell-responses-to-human-platelet-antigen-1a-involve-a-unique-form-of-indirect-allorecognition
#6
Maria Therese Ahlen, Anne Husebekk, Ida Løken Killie, Bjørn Skogen, Tor Brynjar Stuge
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a pregnancy-related condition caused by maternal antibodies binding an alloantigen on fetal platelets. In most cases the alloantigen is formed by a single amino acid, integrin β3 Leu33, referred to as human platelet antigen-1a (HPA-1a). Production of anti-HPA-1a antibodies likely depends on CD4(+) T cells that recognize the same alloantigen in complex with the HLA-DRA/DRB3*01:01 molecule. While this complex is well characterized, T cell recognition of it is not...
September 8, 2016: JCI Insight
https://www.readbyqxmd.com/read/27647765/ep31-02-is-there-an-association-between-diastasis-rectus-abdominis-dra-and-levator-trauma-in-primiparous-women-after-traumatic-labour
#7
V H Eisenberg, L Sela, Y Masharawi
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27634011/lactobacillus-acidophilus-counteracts-inhibition-of-nhe3-and-dra-expression-and-alleviates-diarrheal-phenotype-in-mice-infected-with-citrobacter-rodentium
#8
Anoop Kumar, Arivarasu N Anbazhagan, Hayley Coffing, Ishita Chatterjee, Shubha Priyamvada, Tarunmeet Gujral, Seema Saksena, Ravinder K Gill, Waddah A Alrefai, Alip Borthakur, Pradeep K Dudeja
Impaired absorption of electrolytes is a hallmark of diarrhea associated with inflammation or enteric infections. Intestinal epithelial luminal membrane NHE3 (Na(+)/H(+) exchanger 3) and DRA (Down-Regulated in Adenoma; Cl(-)/HCO3(-) exchanger) play key roles in mediating electroneutral NaCl absorption. We have previously shown decreased NHE3 and DRA function in response to short-term infection with enteropathogenic E coli (EPEC), a diarrheal pathogen. Recent studies have also shown substantial downregulation of DRA expression in a diarrheal model of infection with Citrobacter rodentium, the mouse counterpart of EPEC...
November 1, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27630638/extracellular-vesicles-including-exosomes-regulate-innate-immune-responses-to-hepatitis-b-virus-infection
#9
Takahisa Kouwaki, Yoshimi Fukushima, Takuji Daito, Takahiro Sanada, Naoki Yamamoto, Edin J Mifsud, Chean Ring Leong, Kyoko Tsukiyama-Kohara, Michinori Kohara, Misako Matsumoto, Tsukasa Seya, Hiroyuki Oshiumi
UNLABELLED: The innate immune system is essential for controlling viral infection. Hepatitis B virus (HBV) persistently infects human hepatocytes and causes hepatocellular carcinoma. However, the innate immune response to HBV infection in vivo remains unclear. Using a tree shrew animal model, we showed that HBV infection induced hepatic interferon (IFN)-γ expression during early infection. Our in vitro study demonstrated that hepatic NK cells produced IFN-γ in response to HBV only in the presence of hepatic F4/80(+) cells...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27609017/new-insights-into-the-genetic-component-of-non-infectious-uveitis-through-an-immunochip-strategy
#10
Ana Márquez, Miguel Codero-Coma, José Manuel Martín-Villa, Marina Begoña Gorroño-Echebarría, Ricardo Blanco, David Díaz Valle, María José Del Rio, Ana Blanco, Jose Luis Olea, Yolanda Cordero, María José Capella, Manuel Díaz-Llopis, Norberto Ortego-Centeno, Ioana Ruiz-Arruza, Víctor Llorenç, Alfredo Adán, Alejandro Fonollosa, Josianne Ten Berge, Denize Atan, Andrew D Dick, Joke H De Boer, Jonas Kuiper, Aniki Rothova, Javier Martín
BACKGROUND: Large-scale genetic studies have reported several loci associated with specific disorders involving uveitis. Our aim was to identify genetic risk factors that might predispose to uveitis per se, independent of the clinical diagnosis, by performing a dense genotyping of immune-related loci. METHODS: 613 cases and 3693 unaffected controls from three European case/control sets were genotyped using the Immunochip array. Only patients with non-infectious non-anterior uveitis and without systemic features were selected...
September 8, 2016: Journal of Medical Genetics
https://www.readbyqxmd.com/read/27597964/differential-regulatory-analysis-based-on-coexpression-network-in-cancer-research
#11
REVIEW
Junyi Li, Yi-Xue Li, Yuan-Yuan Li
With rapid development of high-throughput techniques and accumulation of big transcriptomic data, plenty of computational methods and algorithms such as differential analysis and network analysis have been proposed to explore genome-wide gene expression characteristics. These efforts are aiming to transform underlying genomic information into valuable knowledges in biological and medical research fields. Recently, tremendous integrative research methods are dedicated to interpret the development and progress of neoplastic diseases, whereas differential regulatory analysis (DRA) based on gene coexpression network (GCN) increasingly plays a robust complement to regular differential expression analysis in revealing regulatory functions of cancer related genes such as evading growth suppressors and resisting cell death...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27586240/a-novel-integrated-gene-coexpression-analysis-approach-reveals-a-prognostic-three-transcription-factor-signature-for-glioma-molecular-subtypes
#12
Sujuan Wu, Junyi Li, Mushui Cao, Jing Yang, Yi-Xue Li, Yuan-Yuan Li
BACKGROUND: Glioma is the most common brain tumor and it has very high mortality rate due to its infiltration and heterogeneity. Precise classification of glioma subtype is essential for proper therapeutic treatment and better clinical prognosis. However, the molecular mechanism of glioma is far from clear and the classical classification methods based on traditional morphologic and histopathologic knowledge are subjective and inconsistent. Recently, classification methods based on molecular characteristics are developed with rapid progress of high throughput technology...
2016: BMC Systems Biology
https://www.readbyqxmd.com/read/27557396/levator-ani-muscle-injuries-associated-with-vaginal-vacuum-assisted-delivery-determined-by-3-4d-transperineal-ultrasound
#13
J A Garcia-Mejido, Dra L Gutierrez, A Fernandez-Palacín, Dra A Aquise, J A Sainz
OBJECTIVES: To determine the rate of pelvic floor trauma, levator ani muscle (LAM) avulsion as well as the mean difference in levator hiatus area, after normal vaginal deliveries (NVD) and vacuum assisted deliveries (VD), assessed with three-dimensional transperineal ultrasound (3D-TpUS). MATERIALS AND METHODS: Prospective observational study with 151 nulliparous women with NVD or VD at ≥37 weeks between 9-2012 and 6-2013. 3D-TpUS was performed 6 months after every patient's delivery, during which LAM, anteroposterior diameter, transverse diameter and levator hiatus area were assessed...
August 24, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27553076/glp-1-nanomedicine-alleviates-gut-inflammation
#14
Arivarasu N Anbazhagan, Mentor Thaqi, Shubha Priyamvada, Dulari Jayawardena, Anoop Kumar, Tarunmeet Gujral, Ishita Chatterjee, Edurne Mugarza, Seema Saksena, Hayat Onyuksel, Pradeep K Dudeja
The gut hormone, Glucagon like peptide-1 (GLP-1) exerts anti-inflammatory effects. However, its clinical use is limited by its short half-life. Previously, we have shown that GLP-1 as a nanomedicine (GLP-1 in sterically stabilized phospholipid micelles, GLP-1-SSM) has increased in vivo stability. The current study was aimed at testing the efficacy of this GLP-1 nanomedicine in alleviating colonic inflammation and associated diarrhea in dextran sodium sulfate (DSS) induced mouse colitis model. Our results show that GLP-1-SSM treatment markedly alleviated the colitis phenotype by reducing the expression of pro-inflammatory cytokine IL-1β, increasing goblet cells and preserving intestinal epithelial architecture in colitis model...
August 20, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/27532501/first-pass-myocardial-perfusion-mri-with-reduced-subendocardial-dark-rim-artifact-using-optimized-cartesian-sampling
#15
Zhengwei Zhou, Xiaoming Bi, Janet Wei, Hsin-Jung Yang, Rohan Dharmakumar, Reza Arsanjani, C Noel Bairey Merz, Debiao Li, Behzad Sharif
PURPOSE: The presence of subendocardial dark-rim artifact (DRA) remains an ongoing challenge in first-pass perfusion (FPP) cardiac magnetic resonance imaging (MRI). We propose a free-breathing FPP imaging scheme with Cartesian sampling that is optimized to minimize the DRA and readily enables near-instantaneous image reconstruction. MATERIALS AND METHODS: The proposed FPP method suppresses Gibbs ringing effects-a major underlying factor for the DRA-by "shaping" the underlying point spread function through a two-step process: 1) an undersampled Cartesian sampling scheme that widens the k-space coverage compared to the conventional scheme; and 2) a modified parallel-imaging scheme that incorporates optimized apodization (k-space data filtering) to suppress Gibbs-ringing effects...
August 17, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27491873/quantification-of-global-myocardial-function-by-cine-mri-deformable-registration-based-analysis-comparison-with-mr-feature-tracking-and-speckle-tracking-echocardiography
#16
Mariana M Lamacie, Paaladinesh Thavendiranathan, Kate Hanneman, Andreas Greiser, Marie-Pierre Jolly, Richard Ward, Bernd J Wintersperger
OBJECTIVES: To evaluate deformable registration algorithms (DRA)-based quantification of cine steady-state free-precession (SSFP) for myocardial strain assessment in comparison with feature-tracking (FT) and speckle-tracking echocardiography (STE). METHODS: Data sets of 28 patients/10 volunteers, undergoing same-day 1.5T cardiac MRI and echocardiography were included. LV global longitudinal (GLS), circumferential (GCS) and radial (GRS) peak systolic strain were assessed on cine SSFP data using commercially available FT algorithms and prototype DRA-based algorithms...
August 4, 2016: European Radiology
https://www.readbyqxmd.com/read/27471234/t-cells-from-three-hemophilia-a-subjects-recognized-the-same-hla-restricted-fviii-epitope-with-a-narrow-tcr-repertoire
#17
Ruth A Ettinger, Pedro Paz, Eddie A James, Devi Gunasekera, Fred Aswad, Arthur R Thompson, Dana C Matthews, Kathleen P Pratt
Factor VIII (FVIII) neutralizing antibodies ("inhibitors") are a serious problem in hemophilia A (HA). The aim of this study was to characterize HLA-restricted T-cell responses from a severe HA subject with a persistent inhibitor and from two previously studied mild HA inhibitor subjects. MHCII tetramers corresponding to both of the severe HA subject's HLA-DRA-DRB1 alleles were loaded with peptides spanning FVIII-A2, C1 and C2 domains. Interestingly, only one epitope was identified, in peptide FVIII2194-2213, and it was identical to the HLA-DRA*01-DRB1*01:01-restricted epitope recognized by the mild HA subjects...
July 28, 2016: Blood
https://www.readbyqxmd.com/read/27451613/influence-of-parametric-variations-on-hydrothermal-growth-of-zno-nanostructures-for-hybrid-polymer-zno-based-photodetector
#18
Tejendra Dixit, Anubha Bilgaiyan, I A Palani, Vipul Singh
Dumbbell and flower like ZnO nano-crystals were grown via hydrothermal process. The as-prepared dumbbells, with length of 0.8-10 µm and edge length of 0.3-0.8 µm possess a hexagonal structure, while flowers with lengths ranging from 1-6 µm with hexagonal structure have been synthesized. The effect of temperature, solution concentration and growth time on the size and shapes of the ZnO nanostructures has been studied using Field emission scanning electron microscope (FESEM) and X-ray diffractometer (XRD)...
April 2016: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/27445359/genome-wide-association-studies-and-gene-expression-profiles-of-rheumatoid-arthritis-an-analysis
#19
X Xiao, J Hao, Y Wen, W Wang, X Guo, F Zhang
OBJECTIVES: The molecular mechanism of rheumatoid arthritis (RA) remains elusive. We conducted a protein-protein interaction network-based integrative analysis of genome-wide association studies (GWAS) and gene expression profiles of RA. METHODS: We first performed a dense search of RA-associated gene modules by integrating a large GWAS meta-analysis dataset (containing 5539 RA patients and 20 169 healthy controls), protein interaction network and gene expression profiles of RA synovium and peripheral blood mononuclear cells (PBMCs)...
July 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27429004/effect-of-genetic-diversity-in-swine-leukocyte-antigen-dra-gene-on-piglet-diarrhea
#20
Xiaoyu Huang, Qiaoli Yang, Junhu Yuan, Lixia Liu, Wenyang Sun, Yingdi Jiang, Shengguo Zhao, Shengwei Zhang, Wangzhou Huang, Shuangbao Gun
The swine leukocyte antigens (SLAs) are the multigene families related to immune responses. Little is known about the effect of the DRA gene on diarrheal disease. This study reported the genetic diversity of the DRA gene in exons 1, 3 and 4 in 290 Chinese Yantai black pigs. No variation was identified in exon 3. In exon 1, three genotypes and two alleles were identified, generated by two single nucleotide polymorphisms (SNPs). In exon 4, there were eight genotypes and five alleles containing seven SNPs were detected with four SNPs being novel SNPs...
2016: Genes
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