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https://www.readbyqxmd.com/read/28148492/rest-interval-duration-does-not-influence-adaptations-in-acid-base-transport-proteins-following-10-weeks-of-sprint-interval-training-in-active-women
#1
Cian McGinley, David John Bishop
The removal of protons (H(+)) produced during intense exercise is important for skeletal muscle function, yet it remains unclear how best to structure exercise training to improve muscle pH regulation. We investigated whether 4 weeks of work-matched, sprint-interval training (SIT), performed 3 days per week, with either 1 min (Rest-1; n = 7) or 5 min (Rest-5; n = 7) of rest between sprints, influenced adaptations in acid/base transport protein content, non-bicarbonate muscle buffer capacity (βmin vitro), and exercise capacity in active women...
February 1, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28140337/synthesis-of-hierarchical-moo2-mos2-nanofibers-for-electrocatalytic-hydrogen-evolution
#2
Youngwoo Rheem, Yosep Han, Kyu Hwan Lee, Sung-Mook Choi, Nosang V Myung
Perpendicularly attached MoS2 nanosheets on MoO2 conductive nanofibers were synthesized by combining electrospinning, calcination, and sulfurization processes. Compared to randomly stacked MoS2 nanosheets on MoO2 nanofiber, they show greater hydrogen evolution reaction (HER) performance (i.e., onset potential of -180 mV versus normal hydrogen electrode with the Tafel slope of 59 mV dec(-1)). HER performance decreases with increasing MoS2 nanocrystal size.
March 10, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28128323/an-oxidoreductase-aioe-is-responsible-for-bacterial-arsenite-oxidation-and-resistance
#3
Qian Wang, Yushan Han, Kaixiang Shi, Xia Fan, Lu Wang, Mingshun Li, Gejiao Wang
Previously, we found that arsenite (As(III)) oxidation could improve the generation of ATP/NADH to support the growth of Agrobacterium tumefaciens GW4. In this study, we found that aioE is induced by As(III) and located in the arsenic island near the As(III) oxidase genes aioBA and co-transcripted with the arsenic resistant genes arsR1-arsC1-arsC2-acr3-1. AioE belongs to TrkA family corresponding the electron transport function with the generation of NADH and H(+). An aioE in-frame deletion strain showed a null As(III) oxidation and a reduced As(III) resistance, while a cytC mutant only reduced As(III) oxidation efficiency...
January 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28099777/positive-selection-on-sperm-ion-channels-in-a-brooding-brittle-star-consequence-of-life-history-traits-evolution
#4
A A-T Weber, L Abi-Rached, N Galtier, A Bernard, J I Montoya-Burgos, A Chenuil
Closely related species are key models to investigate mechanisms leading to reproductive isolation and early stages of diversification, also at the genomic level. The brittle star cryptic species complex Ophioderma longicauda encompasses the sympatric broadcast spawning species C3 and the internal brooding species C5. Here we used de novo transcriptome sequencing and assembly in two closely related species displaying contrasting reproductive modes to compare their genetic diversity and to investigate the role of natural selection in reproductive isolation...
January 18, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28090568/pathophysiology-of-intestinal-na-h-exchange
#5
Michael A Gurney, Daniel Laubitz, Fayez K Ghishan, Pawel R Kiela
Several members of the SLC9A family of Na(+)/H(+) exchangers are expressed in the gut, with varying expression patterns and cellular localization. Not only do they participate in the regulation of basic epithelial cell functions, including control of transepithelial Na(+) absorption, intracellular pH (pH i ), cell volume, and nutrient absorption, but also in cellular proliferation, migration, and apoptosis. Additionally, they modulate the extracellular milieu in order to facilitate other nutrient absorption and to regulate the intestinal microbial microenvironment...
January 2017: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28056749/development-and-evaluation-of-naproxen-sodium-gel-using-piper-cubeba-for-enhanced-transdermal-drug-delivery-and-therapeutic-facilitation
#6
Sunetra Kaustubh Patwardhan, Manohar J Patil, Anbazhagan Sockalingam
BACKGROUND: The absorption of drug through skin avoids many side effects of oral route like gastric irritation, nausea, systemic toxicity etc and thus improves patient compliance. Naproxen sodium (NPRS) is one of the potent NSAID agents. OBJECTIVE: The present study was aimed to develop and evaluate the gel formulation containing NPRS for transdermal drug delivery reducing the side effects and improving patient compliance. The patents on topical delivery of NSAIDS (US 9012402 B1, US 9072659 B2, US 20150258196 A1) and patents indicating use of herbal penetration enhancers (US 20100273746A1, WO 2005009510 A2, US 6004969 A) helped in selecting the drug, excipients...
January 5, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/28019659/na-h-exchanger-nhe1-and-nhe2-have-opposite-effects-on-migration-velocity-in-the-rat-gastric-surface-cells
#7
Anja Paehler Vor der Nolte, Giriprakash Chodisetti, Zhenglin Yuan, Florian Busch, Brigitte Riederer, Min Luo, Yan Yu, Manoj B Menon, Andreas Schneider, Renata Stripecke, Katerina Nikolovska, Sunil Yeruva, Ursula Seidler
Following superficial injury, neighbouring gastric epithelial cells close the wound by rapid cell migration, a process called epithelial restitution. Na(+) /H(+) exchange (NHE) inhibitors interfere with restitution, but the role of the different NHE isoforms expressed in gastric pit cells has remained elusive. The role of the basolaterally expressed NHE1 (Slc9a1) and the presumably apically expressed NHE2 (Slc9a2) in epithelial restitution was investigated in the nontransformed rat gastric surface cell line RGM1...
December 26, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28003213/molecular-mechanisms-underlying-active-desalination-and-low-water-permeability-in-the-esophagus-of-eels-acclimated-to-seawater
#8
Yoshio Takei, Marty Kwok-Shing Wong, Supriya Pipil, Haruka Ozaki, Yutaka Suzuki, Wataru Iwasaki, Makoto Kusakabe
Marine teleosts can absorb imbibed seawater (SW) to maintain water balance, with esophageal desalination playing an essential role. NaCl absorption from luminal SW was enhanced 10-fold in the esophagus of SW-acclimated eels, and removal of Na(+) or Cl(-) from luminal SW abolished the facilitated absorption, indicating coupled transport. Mucosal/serosal application of various blockers for Na(+)/Cl(-) transporters profoundly decreased the absorption. Among the transporter genes expressed in eel esophagus detected by RNA-seq, dimethyl amiloride-sensitive Na(+)/H(+) exchanger (NHE3) and 4,4'-diisothiocyano-2,2'-disulfonic acid-sensitive Cl(-)/HCO3(-) exchanger (AE) coupled by the scaffolding protein on the apical membrane of epithelial cells, and ouabain-sensitive Na(+)/K(+)-ATPases (NKA1α1c and NKA3α) and diphenylamine-2-carboxylic acid-sensitive Cl(-) channel (CLCN2) on the basolateral membrane, may be responsible for enhanced transcellular NaCl transport because of their profound upregulation after SW acclimation...
December 21, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27995414/na-h-exchanger-3-inhibitor-diminishes-hepcidin-enhanced-duodenal-calcium-transport-in-hemizygous-%C3%AE-globin-knockout-thalassemic-mice
#9
Narattaphol Charoenphandhu, Kamonshanok Kraidith, Kornkamon Lertsuwan, Chanakarn Sripong, Panan Suntornsaratoon, Saovaros Svasti, Nateetip Krishnamra, Kannikar Wongdee
Recent investigation has shown that the liver-derived iron-regulating hormone, hepcidin, can potentiate intestinal calcium absorption in hemizygous β-globin knockout thalassemic (BKO) mice. Since the upregulation of Fe(2+) and H(+) cotransporter, divalent metal transporter (DMT)-1, has been shown to correlate with thalassemia-induced intestinal calcium absorption impairment, the inhibition of the apical Na(+)/H(+) exchanger (NHE)-3 that is essential for cytoplasmic pH regulation and transepithelial sodium absorption was hypothesized to negatively affect hepcidin action...
March 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27981415/na-h-exchanger-3-inhibitor-diminishes-the-amino-acid-enhanced-transepithelial-calcium-transport-across-the-rat-duodenum
#10
Nithipak Thammayon, Kannikar Wongdee, Kornkamon Lertsuwan, Panan Suntornsaratoon, Jirawan Thongbunchoo, Nateetip Krishnamra, Narattaphol Charoenphandhu
Na(+)/H(+) exchanger (NHE)-3 is important for intestinal absorption of nutrients and minerals, including calcium. The previous investigations have shown that the intestinal calcium absorption is also dependent on luminal nutrients, but whether aliphatic amino acids and glucose, which are abundant in the luminal fluid during a meal, similarly enhance calcium transport remains elusive. Herein, we used the in vitro Ussing chamber technique to determine epithelial electrical parameters, i.e., potential difference (PD), short-circuit current (Isc), and transepithelial resistance, as well as (45)Ca flux in the rat duodenum directly exposed on the mucosal side to glucose or various amino acids...
December 15, 2016: Amino Acids
https://www.readbyqxmd.com/read/27976525/electrochemical-water-oxidation-by-a-catalyst-modified-metal-organic-framework-thin-film
#11
Shaoyang Lin, Yuliana Pineda-Galvan, William A Maza, Charity C Epley, Jie Zhu, Matthew C Kessinger, Yulia Pushkar, Amanda J Morris
Water oxidation, a key component in artificial photosynthesis, requires high overpotentials and exhibits slow reaction kinetics that necessitates the use of stable and efficient heterogeneous water-oxidation catalysts (WOCs). Here, we report the synthesis of UiO-67 metal-organic framework (MOF) thin films doped with [Ru(tpy)(dcbpy)OH2 ](2+) (tpy=2,2':6',2''-terpyridine, dcbpy=5,5'-dicarboxy-2,2'-bipyridine) on conducting surfaces and their propensity for electrochemical water oxidation. The electrocatalyst oxidized water with a turnover frequency (TOF) of (0...
December 15, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27934583/bacillus-cereus-induced-food-borne-outbreaks-in-france-2007-to-2014-epidemiology-and-genetic-characterisation
#12
Benjamin Glasset, Sabine Herbin, Laurent Guillier, Sabrina Cadel-Six, Marie-Léone Vignaud, Joel Grout, Sylvie Pairaud, Valérie Michel, Jacques-Antoine Hennekinne, Nalini Ramarao, Anne Brisabois
The aim of this study was to identify and characterise Bacillus cereus from a unique national collection of 564 strains associated with 140 strong-evidence food-borne outbreaks (FBOs) occurring in France during 2007 to 2014. Starchy food and vegetables were the most frequent food vehicles identified; 747 of 911 human cases occurred in institutional catering contexts. Incubation period was significantly shorter for emetic strains compared with diarrhoeal strains A sub-panel of 149 strains strictly associated to 74 FBOs and selected on Coliphage M13-PCR pattern, was studied for detection of the genes encoding cereulide, diarrhoeic toxins (Nhe, Hbl, CytK1 and CytK2) and haemolysin (HlyII), as well as panC phylogenetic classification...
December 1, 2016: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/27923711/characterization-of-na-transport-to-gain-insight-into-the-mechanism-of-acid-base-and-ion-regulation-in-white-sturgeon-acipenser-transmontanus
#13
Ryan B Shartau, Kevin V Brix, Colin J Brauner
Freshwater fish actively take up ions via specific transporters to counter diffusive losses to their hypotonic environment. While much is known about the specific mechanisms employed by teleosts, almost nothing is known about the basal fishes, such as white sturgeon (Acipenser transmontanus) which may offer insight into the evolution of osmo- and ionoregulation in fishes. We investigated Na(+) uptake in juvenile white sturgeon in the presence and absence of transporter inhibitors. We found that sturgeon acclimated to 100μmoll(-1) Na(+) have Na(+) uptake kinetics typical of teleosts and that a Na(+)/H(+) exchanger (NHE) is the predominant transporter for Na(+) uptake...
February 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/27921384/a-robust-molecular-catalyst-generated-in-situ-for-photo-and-electrochemical-water-oxidation
#14
Hussein A Younus, Nazir Ahmad, Adeel H Chughtai, Matthias Vandichel, Michael Busch, Kristof Van Hecke, Mekhman Yusubov, Shaoxian Song, Francis Verpoort
Water splitting is the key step towards artificial photosystems for solar energy conversion and storage in the form of chemical bonding. The oxidation of water is the bottle-neck of this process that hampers its practical utility and hence efficient, robust, and also easy to make catalytic systems based on cheap and earth abundant materials are of exceptional importance. Here, we present an in-situ generated cobalt catalyst [Co(II)(TCA)2(H2O)2] (TCA = 1-Mesityl-1,2,3-1H-triazole-4-carboxylate) efficiently conducting photochemical water oxidation at near-neutral conditions...
December 5, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27897422/a-million-turnover-molecular-anode-for-catalytic-water-oxidation
#15
Jordi Creus, Roc Matheu, Itziar Peñafiel, Dooshaye Moonshiram, Pascal Blondeau, Jordi Benet-Buchholz, Jordi García-Antón, Xavier Sala, Cyril Godard, Antoni Llobet
Molecular ruthenium-based water oxidation catalyst precursors of general formula [Ru(tda)(L(i) )2 ] (tda(2-) is [2,2':6',2''-terpyridine]-6,6''-dicarboxylato; L(1) =4-(pyren-1-yl)-N-(pyridin-4-ylmethyl)butanamide, 1 b; L(2) =4-(pyren-1-yl)pyridine), 1 c), have been prepared and thoroughly characterized. Both complexes contain a pyrene group allowing ready and efficiently anchoring via π interactions on multi-walled carbon nanotubes (MWCNT). These hybrid solid state materials are exceptionally stable molecular water-oxidation anodes capable of carrying out more than a million turnover numbers (TNs) at pH 7 with an Eapp =1...
December 5, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27887666/contributions-of-national-and-global-health-estimates-to-monitoring-health-related-sustainable-development-goals
#16
Kanitta Bundhamcharoen, Supon Limwattananon, Khanitta Kusreesakul, Viroj Tangcharoensathien
The millennium development goals triggered an increased demand for data on child and maternal mortalities for monitoring progress. With the advent of the sustainable development goals and growing evidence of an epidemiological transition toward non-communicable diseases, policymakers need data on mortality and disease trends and distribution to inform effective policies and support monitoring progress. Where there are limited capacities to produce national health estimates (NHEs), global health estimates (GHEs) can fill gaps for global monitoring and comparisons...
2016: Global Health Action
https://www.readbyqxmd.com/read/27868160/severe-changes-in-colon-epithelium-in-the-mecp2-null-mouse-model-of-rett-syndrome
#17
Pamela Millar-Büchner, Amber R Philp, Noemí Gutierrez, Sandra Villanueva, Bredford Kerr, Carlos A Flores
BACKGROUND: Rett syndrome is best known due to its severe and devastating symptoms in the central nervous system. It is produced by mutations affecting the Mecp2 gene that codes for a transcription factor. Nevertheless, evidence for MECP2 activity has been reported for tissues other than those of the central nervous system. Patients affected by Rett presented with intestinal affections whose origin is still not known. We have observed that the Mecp2-null mice presented with episodes of diarrhea, and decided to study the intestinal phenotype in these mice...
December 2016: Molecular and Cellular Pediatrics
https://www.readbyqxmd.com/read/27849940/298-nhe-1-inhibition-lessens-adverse-post-resuscitation-myocardial-effects-caused-by-severe-alkalemia
#18
Lorissa Lamoureux, Jeejabai Radhakrishnan, Thomas Mason, Jeffrey Kraut, Raúl Gazmuri
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27827957/screening-of-cytotoxic-b-cereus-on-differentiated-caco-2-cells-and-in-co-culture-with-mucus-secreting-ht29-mtx-cells
#19
Virginie Castiaux, Laurie Laloux, Yves-Jacques Schneider, Jacques Mahillon
B. cereus is an opportunistic foodborne pathogen able to cause diarrhoea. However, the diarrhoeal potential of a B. cereus strain remains difficult to predict, because no simple correlation has yet been identified between the symptoms and a unique or a specific combination of virulence factors. In this study, 70 B. cereus strains with different origins (food poisonings, foods and environment) have been selected to assess their enterotoxicity. The B. cereus cell-free supernatants have been tested for their toxicity in vitro, on differentiated (21 day-old) Caco-2 cells, using their ATP content, LDH release and NR accumulation...
November 5, 2016: Toxins
https://www.readbyqxmd.com/read/27816051/molecular-features-of-the-cytotoxicity-of-an-nhe-inhibitor-evidence-of-mitochondrial-alterations-ros-overproduction-and-dna-damage
#20
Francesca Aredia, Sebastian Czaplinski, Simone Fulda, A Ivana Scovassi
BACKGROUND: NH exchangers (NHEs) play a crucial role in regulating intra/extracellular pH, which is altered in cancer cells, and are therefore suitable targets to alter cancer cell metabolism in order to inhibit cell survival and proliferation. Among NHE inhibitors, amiloride family members are commonly used in clinical practice as diuretics; we focused on the amiloride HMA, reporting a net cytotoxic effect on a panel of human cancer cell lines; now we aim to provide new insights into the molecular events leading to cell death by HMA...
November 5, 2016: BMC Cancer
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