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https://www.readbyqxmd.com/read/27897422/a-million-turnover-molecular-anode-for-catalytic-water-oxidation
#1
Jordi Creus, Roc Matheu, Itziar Peñafiel, Dooshaye Moonshiram, Pascal Blondeau, Jordi Benet-Buchholz, Jordi García-Antón, Xavier Sala, Cyril Godard, Antoni Llobet
Molecular ruthenium-based water oxidation catalyst precursors of general formula [Ru(tda)(L(i) )2 ] (tda(2-) is [2,2':6',2''-terpyridine]-6,6''-dicarboxylato; L(1) =4-(pyren-1-yl)-N-(pyridin-4-ylmethyl)butanamide, 1 b; L(2) =4-(pyren-1-yl)pyridine), 1 c), have been prepared and thoroughly characterized. Both complexes contain a pyrene group allowing ready and efficiently anchoring via π interactions on multi-walled carbon nanotubes (MWCNT). These hybrid solid state materials are exceptionally stable molecular water-oxidation anodes capable of carrying out more than a million turnover numbers (TNs) at pH 7 with an Eapp =1...
December 5, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27887666/contributions-of-national-and-global-health-estimates-to-monitoring-health-related-sustainable-development-goals
#2
Kanitta Bundhamcharoen, Supon Limwattananon, Khanitta Kusreesakul, Viroj Tangcharoensathien
The millennium development goals triggered an increased demand for data on child and maternal mortalities for monitoring progress. With the advent of the sustainable development goals and growing evidence of an epidemiological transition toward non-communicable diseases, policymakers need data on mortality and disease trends and distribution to inform effective policies and support monitoring progress. Where there are limited capacities to produce national health estimates (NHEs), global health estimates (GHEs) can fill gaps for global monitoring and comparisons...
2016: Global Health Action
https://www.readbyqxmd.com/read/27868160/severe-changes-in-colon-epithelium-in-the-mecp2-null-mouse-model-of-rett-syndrome
#3
Pamela Millar-Büchner, Amber R Philp, Noemí Gutierrez, Sandra Villanueva, Bredford Kerr, Carlos A Flores
BACKGROUND: Rett syndrome is best known due to its severe and devastating symptoms in the central nervous system. It is produced by mutations affecting the Mecp2 gene that codes for a transcription factor. Nevertheless, evidence for MECP2 activity has been reported for tissues other than those of the central nervous system. Patients affected by Rett presented with intestinal affections whose origin is still not known. We have observed that the Mecp2-null mice presented with episodes of diarrhea, and decided to study the intestinal phenotype in these mice...
December 2016: Molecular and Cellular Pediatrics
https://www.readbyqxmd.com/read/27849940/298-nhe-1-inhibition-lessens-adverse-post-resuscitation-myocardial-effects-caused-by-severe-alkalemia
#4
Lorissa Lamoureux, Jeejabai Radhakrishnan, Thomas Mason, Jeffrey Kraut, Raúl Gazmuri
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27827957/screening-of-cytotoxic-b-cereus-on-differentiated-caco-2-cells-and-in-co-culture-with-mucus-secreting-ht29-mtx-cells
#5
Virginie Castiaux, Laurie Laloux, Yves-Jacques Schneider, Jacques Mahillon
B. cereus is an opportunistic foodborne pathogen able to cause diarrhoea. However, the diarrhoeal potential of a B. cereus strain remains difficult to predict, because no simple correlation has yet been identified between the symptoms and a unique or a specific combination of virulence factors. In this study, 70 B. cereus strains with different origins (food poisonings, foods and environment) have been selected to assess their enterotoxicity. The B. cereus cell-free supernatants have been tested for their toxicity in vitro, on differentiated (21 day-old) Caco-2 cells, using their ATP content, LDH release and NR accumulation...
November 5, 2016: Toxins
https://www.readbyqxmd.com/read/27816051/molecular-features-of-the-cytotoxicity-of-an-nhe-inhibitor-evidence-of-mitochondrial-alterations-ros-overproduction-and-dna-damage
#6
Francesca Aredia, Sebastian Czaplinski, Simone Fulda, A Ivana Scovassi
BACKGROUND: NH exchangers (NHEs) play a crucial role in regulating intra/extracellular pH, which is altered in cancer cells, and are therefore suitable targets to alter cancer cell metabolism in order to inhibit cell survival and proliferation. Among NHE inhibitors, amiloride family members are commonly used in clinical practice as diuretics; we focused on the amiloride HMA, reporting a net cytotoxic effect on a panel of human cancer cell lines; now we aim to provide new insights into the molecular events leading to cell death by HMA...
November 5, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27804084/ion-transport-its-regulation-in-the-endolymphatic-sac-suggestions-for-clinical-aspects-of-meniere-s-disease
#7
REVIEW
Nozomu Mori, Takenori Miyashita, Ryuhei Inamoto, Ai Matsubara, Terushige Mori, Kosuke Akiyama, Hiroshi Hoshikawa
Ion transport and its regulation in the endolymphatic sac (ES) are reviewed on the basis of recent lines of evidence. The morphological and physiological findings demonstrate that epithelial cells in the intermediate portion of the ES are more functional in ion transport than those in the other portions. Several ion channels, ion transporters, ion exchangers, and so on have been reported to be present in epithelial cells of ES intermediate portion. An imaging study has shown that mitochondria-rich cells in the ES intermediate portion have a higher activity of Na(+), K(+)-ATPase and a higher Na(+) permeability than other type of cells, implying that molecules related to Na(+) transport, such as epithelial sodium channel (ENaC), Na(+)-K(+)-2Cl(-) cotransporter 2 (NKCC2) and thiazide-sensitive Na(+)-Cl(-) cotransporter (NCC), may be present in mitochondria-rich cells...
November 1, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27790155/exercise-attenuates-intermittent-hypoxia-induced-cardiac-fibrosis-associated-with-sodium-hydrogen-exchanger-1-in-rats
#8
Tsung-I Chen, Wei-Chia Tu
Purpose: To investigate the role of sodium-hydrogen exchanger-1 (NHE-1) and exercise training on intermittent hypoxia-induced cardiac fibrosis in obstructive sleep apnea (OSA), using an animal model mimicking the intermittent hypoxia of OSA. Methods: Eight-week-old male Sprague-Dawley rats were randomly assigned to control (CON), intermittent hypoxia (IH), exercise (EXE), or IH combined with exercise (IHEXE) groups. These groups were randomly assigned to subgroups receiving either a vehicle or the NHE-1 inhibitor cariporide...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27789698/nucleic-acid-clamp-mediated-recognition-and-stabilization-of-the-physiologically-relevant-myc-promoter-g-quadruplex
#9
Taisen Hao, Vanessa C Gaerig, Tracy A Brooks
The MYC proto-oncogene is upregulated, often at the transcriptional level, in ∼80% of all cancers. MYC's promoter is governed by a higher order G-quadruplex (G4) structure in the NHE III1 region. Under a variety of conditions, multiple isoforms have been described to form from the first four continuous guanine runs (G41-4) predominating under the physiologically relevant supercoiled conditions. In the current study, short oligonucleotides complementing the 5'- and 3'-regions flanking the G4 have been connected by an abasic linker to form G4 clamps, varying both linker length and G4 isoform being targeted...
October 26, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27788451/pre-acclimation-to-low-ammonia-improves-ammonia-handling-in-common-carp-cyprinus-carpio-when-exposed-subsequently-to-high-environmental-ammonia
#10
Jyotsna Shrivastava, Amit Kumar Sinha, Surjya Narayan Datta, Ronny Blust, Gudrun De Boeck
We tested whether exposing fish to low ammonia concentrations induced acclimation processes and helped fish to tolerate subsequent (sub)lethal ammonia exposure by activating ammonia excretory pathways. Common carp (Cyprinus carpio) were pre-exposed to 0.27mM ammonia (∼10% 96h LC50) for 3, 7 and 14days. Thereafter, each of these pre-exposed and parallel naïve groups were exposed to 1.35mM high environmental ammonia (HEA, ∼50% 96h LC50) for 12h and 48h to assess the occurrence of ammonia acclimation based on sub-lethal end-points, and to lethal ammonia concentrations (2...
October 21, 2016: Aquatic Toxicology
https://www.readbyqxmd.com/read/27768742/antibody-binding-studies-reveal-conformational-flexibility-of-the-bacillus-cereus-non-hemolytic-enterotoxin-nhe-a-component
#11
A Didier, R Dietrich, E Märtlbauer
The non-hemolytic enterotoxin complex (Nhe) is supposed to be the main virulence factor of B. cereus causing a diarrheal outcome of food poisoning. This tripartite toxin consists of the single components NheA, -B and -C all of them being necessary for maximum toxicity. In the past, research activities aiming to elucidate the mode-of-action of Nhe were mostly focused on the B- and C-component. In this study the generation of novel monoclonal antibodies (mAb) and their thorough characterization enabled the determination of key features for NheA...
2016: PloS One
https://www.readbyqxmd.com/read/27762484/-non-haemolytic-enterotoxin-nhe-of-bacillus-cereus-induces-apoptosis-in-vero-cells
#12
Xiaoye Liu, Shuangyang Ding, Peijie Shi, Richard Dietrich, Erwin Märtlbauer, Kui Zhu
Bacillus cereus is an opportunistic pathogen that often causes foodborne infectious diseases and food poisoning. Non-haemolytic enterotoxin (Nhe) is the major toxin found in almost all enteropathogenic B. cereus and B. thuringiensis isolates. However, little is known about the cellular response after Nhe triggered pore formation on cell membrane. Here we demonstrate that Nhe induced cell cycle arrest at G0 /G1 phase and provoked apoptosis in Vero cells, most likely associated with mitogen-activated protein kinase (MAPK) and death receptor pathways...
October 20, 2016: Cellular Microbiology
https://www.readbyqxmd.com/read/27761064/human-cytochrome-p450-enzyme-modulation-by-gymnema-sylvestre-a-predictive-safety-evaluation-by-lc-ms-ms
#13
Bera Rammohan, Karmakar Samit, Das Chinmoy, Saha Arup, Kundu Amit, Sarkar Ratul, Karmakar Sanmoy, Adhikari Dipan, Sen Tuhinadri
BACKGROUND: Traditionally GS is used to treat diabetes mellitus. Drug-herb interaction of GS via cytochrome P450 enzyme system by substrate cocktail method using HLM has not been reported. OBJECTIVE: To evaluate the in-vitro modulatory effects of GS extracts (aqueous, methanol, ethyl acetate, chloroform and n-hexane) and deacylgymnemic acid (DGA) on human CYP1A2, 2C8, 2C9, 2D6 and 3A4 activities in HLM. MATERIAL AND METHODS: Probe substrate-based LCMS/MS method was established for all CYPs...
July 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27752710/empagliflozin-decreases-myocardial-cytoplasmic-na-through-inhibition-of-the-cardiac-na-h-exchanger-in-rats-and-rabbits
#14
Antonius Baartscheer, Cees A Schumacher, Rob C I Wüst, Jan W T Fiolet, Ger J M Stienen, Ruben Coronel, Coert J Zuurbier
AIMS/HYPOTHESIS: Empagliflozin (EMPA), an inhibitor of the renal sodium-glucose cotransporter (SGLT) 2, reduces the risk of cardiovascular death in patients with type 2 diabetes. The underlying mechanism of this effect is unknown. Elevated cardiac cytoplasmic Na(+) ([Na(+)]c) and Ca(2+) ([Ca(2+)]c) concentrations and decreased mitochondrial Ca(2+) concentration ([Ca(2+)]m) are drivers of heart failure and cardiac death. We therefore hypothesised that EMPA would directly modify [Na(+)]c, [Ca(2+)]c and [Ca(2+)]m in cardiomyocytes...
October 17, 2016: Diabetologia
https://www.readbyqxmd.com/read/27750152/sodium-hydrogen-exchanger-inhibitory-activity-of-benzotriazole-derivatives
#15
Dhandeep Singh, Om Silakari
Series of benzotriazole derivatives were synthesized and evaluated for their Sodium hydrogen exchanger-1 inhibitory potential. All compounds inhibit Sodium hydrogen exchanger-1 in the in-vitro platelet swelling assay. This is perhaps the first report of NHE-1 inhibitory activity of benzotriazole. The 1-alkyl benzotriazole derivatives were found to be more active than the 2-alkyl isomers. The activity increases with increase in chain length of alkyl moiety. Potency increased from that of benzotriazole (IC50 = 192...
October 5, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27744366/genotypic-heterogeneity-of-emetic-toxin-producing-bacillus-cereus-isolates-from-china
#16
Yong Yang, Hua Gu, Xiaofeng Yu, Li Zhan, Jiancai Chen, Yun Luo, Yunyi Zhang, Yanjun Zhang, Yiyu Lu, Jianmin Jiang, Lingling Mei
Emetic toxin producing Bacillus cereus (emetic B. cereus) is the third member of B. cereus group whose toxins are encoded by megaplasmids, beside anthrax and insecticidal toxins of B. anthracis and B. thuringiensis respectively. 18 emetic isolates collected from food poisoning events, clinical and non-random food samples in Zhejiang province of China, were analyzed by plasmid screening, pulse field gel electrophoresis (PFGE), multi-locus sequence typing (MLST), as well as toxic gene identification to investigate their genotypic diversity...
October 14, 2016: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/27742804/influence-of-training-intensity-on-adaptations-in-acid-base-transport-proteins-muscle-buffer-capacity-and-repeated-sprint-ability-in-active-men
#17
Cian McGinley, David John Bishop
This study measured the adaptive response to exercise training for each of the acid/base transport protein families, including providing isoform-specific evidence for the monocarboxylate transporter (MCT)1/4 chaperone protein basigin and for the electrogenic sodium/bicarbonate cotransporter (NBCe)1. We investigated whether 4 weeks of work-matched, high-intensity interval training (HIIT), performed either just above the lactate threshold (HIITΔ20; n = 8), or close to peak aerobic power (HIITΔ90; n = 8), influenced adaptations in acid/base transport protein abundance, non-bicarbonate muscle buffer capacity (βmin vitro), and exercise capacity in active men...
October 14, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27722596/anisotropic-etching-of-rhodium-and-gold-as-the-onset-of-nanoparticle-formation-by-cathodic-corrosion
#18
Thomas J P Hersbach, Vladislav A Mints, Federico Calle-Vallejo, Alexei I Yanson, Marc T M Koper
Cathodic corrosion is a phenomenon in which negatively polarized metal electrodes are degraded by cathodic etching and nanoparticle formation. Though these changes are dramatic and sometimes even visible by eye, the exact mechanisms underlying cathodic corrosion are still unclear. This work aims to improve the understanding of cathodic corrosion by studying its onset on rhodium and gold electrodes, which are subjected to various constant cathodic potentials in 10 M NaOH. After this polarization, the electrodes are studied using cyclic voltammetry and scanning electron microscopy, allowing a corrosion onset potential of -1...
September 15, 2016: Faraday Discussions
https://www.readbyqxmd.com/read/27722546/voltammetry-and-molecular-assembly-of-g-quadruplex-dnazyme-on-single-crystal-au-111-electrode-surfaces-hemin-as-an-electrochemical-intercalator
#19
Ling Zhang, Jens Ulstrup, Jingdong Zhang
DNA quadruplexes (qs) are a class of "non-canonical" oligonucleotides (OGNs) composed of stacked guanine (G) quartets stabilized by specific cations. Metal porphyrins selectively bind to G-qs complexes to form what is known as DNAzyme, which can exhibit peroxidase and other catalytic activity similar to heme group metalloenzymes. In the present study we investigate the electrochemical properties and the structure of DNAzyme monolayers on single-crystal Au(111)-electrode surfaces using cyclic voltammetry and scanning tunnelling microscopy under electrochemical potential control (in situ STM)...
September 20, 2016: Faraday Discussions
https://www.readbyqxmd.com/read/27716463/one-dimensional-sno2-nrs-fe2o3-nts-with-dual-synergistic-effects-for-photoelectrocatalytic-reduction-co2-into-methanol
#20
Zhongxue Yang, Huying Wang, Weijie Song, Wei Wei, Qingping Mu, Bo Kong, Peiqiang Li, Hongzong Yin
The hydrothermal method was explored to prepare SnO2 nanorods (SnO2 NRs) with the special faces of (110) and (101) on the surface of Fe2O3 nanotubes (Fe2O3 NTs). According to the SEM and XRD results, the formation process of the hierarchically assembled SnO2 NRs was deduced. The SnO2 NRs/Fe2O3 NTs catalyst that had reached for 120 mins behaved the best photoelectrocatalytic properties. From the view of photocatalytic reduction, the conduction band (-0.75eV vs NHE) is negative enough to drive CO2 reduction, and the valence band (1...
September 24, 2016: Journal of Colloid and Interface Science
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