keyword
MENU ▼
Read by QxMD icon Read
search

e.n.t.

keyword
https://www.readbyqxmd.com/read/29232694/hyperbranched-poly-%C3%AF%C2%B5-lysine-substrate-presenting-the-laminin-sequence-yigsr-induces-the-formation-of-spheroids-in-adult-bone-marrow-stem-cells
#1
Valeria Perugini, Steve T Meikle, Anna L Guildford, Matteo Santin
Unlike the fibroblast-like cells formed upon monolayer culture of human mesenchymal stem cells, the natural stem cell niche of the bone marrow and other types of tissues favours the formation of 3-dimensional (3D) cell clusters. The structuring and biological activity of these clusters are regulated by the contacts established by cells with both the basement membrane and neighbour cells and results in their asymmetric division and the consequent maintenance of both a stem population and a committed progeny...
2017: PloS One
https://www.readbyqxmd.com/read/29232576/effects-of-oxytocin-on-cortisol-reactivity-and-conflict-resolution-behaviors-among-couples-with-substance-misuse
#2
Julianne C Flanagan, Melanie S Fischer, Paul J Nietert, Sudie E Back, Megan Moran-Santa Maria, Alexandra Snead, Kathleen T Brady
Social stress, particularly in the form of dyadic conflict, is a well-established correlate of substance use disorders (SUD). The neuropeptide oxytocin can enhance prosocial behavior and mitigate addictive behaviors. These effects may be, in part, a result of oxytocin's ability to attenuate hypothalamic-pituitary-adrenal (HPA) axis dysregulation. However, only one study to date has examined the effects of oxytocin on neuroendocrine reactivity or conflict resolution behavior among couples. Participants (N = 33 couples or 66 total participants) were heterosexual couples in which one or both partners endorsed substance misuse...
December 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29232397/distribution-and-prevalence-of-vector-borne-diseases-in-california-chipmunks-tamias-spp
#3
Mary H Straub, Austin N Roy, Amanda Martin, Kathleen E Sholty, Nicole Stephenson, Janet E Foley
California, with 13 chipmunk (Tamias) species, has more than any other state or country, occupying habitats ranging from chaparral to the high peaks of the Sierra Nevada. Chipmunks host zoonotic pathogens including Yersinia pestis, Anaplasma phagocytophilum, relapsing fever (RF) Borrelia spp., Borrelia burgdorferi, and spotted fever group (SFG) Rickettsia species. Chipmunk species are often not differentiated by public health workers, yet different species utilize different ecological niches and may have intrinsically different capacities for maintaining vector-borne pathogens and infecting vectors...
2017: PloS One
https://www.readbyqxmd.com/read/29231798/n-cadherin-knockdown-leads-to-disruption-of-trophoblastic-and-endothelial-cell-interaction-in-a-3d-cell-culture-model-new-insights-in-trophoblast-invasion-failure
#4
A Multhaup, B Huppertz, C Göhner, M Böhringer, M Mai, U Markert, E Schleußner, T Groten
INTRODUCTION: Trophoblast homing to maternal spiral arteries is mandatory for successful placentation. Cell-cell adhesion molecules regulate this process and adhesion molecule expression is altered in impaired placentation. We hypothesize that, similar to immune cell recruitment, trophoblast cell adherence and rolling are primarily mediated by adhesion molecules like, cadherins, immunoglobulins, selectins and their partnering ligands. Here, the interdependence of adhesion molecule expression in trophoblastic cell lines of diverse origin was investigated in relation to their interaction with endothelial cell networks on Matrigel® co-cultures and the effect of specific adhesion molecule knockdown analyzed...
December 12, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/29230875/kinetics-of-plasma-cell-free-dna-and-creatine-kinase-in-a-canine-model-of-tissue-injury
#5
I J Wilson, R K Burchell, A J Worth, S E Burton, K R Gedye, K J Clark, K R Crosse, M Jack, T F Odom, S J De Grey, K M S McGlade, S C Tomlin, N Lopez-Villalobos, A Gal
BACKGROUND: Cell-free DNA (cfDNA) comprises short, double-stranded circulating DNA sequences released from damaged cells. In people, cfDNA concentrations correlate well with disease severity and tissue damage. No reports are available regarding cfDNA kinetics in dogs. OBJECTIVES/HYPOTHESIS: Cell-free DNA will have a short biological half-life and would be able to stratify mild, moderate, and severe tissue injury. Our study aims were to determine the kinetics and biological half-life of cfDNA and to contrast them with those of creatine kinase (CK)...
December 12, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29230511/quality-of-life-for-up-to-18%C3%A2-months-after-low-energy-hip-vertebral-and-distal-forearm-fractures-results-from-the-icuros
#6
A Svedbom, F Borgstöm, E Hernlund, O Ström, V Alekna, M L Bianchi, P Clark, M D Curiel, H P Dimai, M Jürisson, R Kallikorm, M Lember, O Lesnyak, E McCloskey, K M Sanders, S Silverman, A Solodovnikov, M Tamulaitiene, T Thomas, N Toroptsova, A Uusküla, A N A Tosteson, B Jönsson, J A Kanis
This study used data from the International Costs and Utilities Related to Osteoporotic fractures Study (ICUROS) to estimate the quality of life (QoL) impact of fracture. Hip, vertebral, and distal forearm fractures incur substantial QoL losses. Hip and vertebral fracture results in markedly impaired QoL for at least 18 months. INTRODUCTION: The International Costs and Utilities Related to Osteoporotic fractures Study (ICUROS) is a multinational observational study that aims to describe costs and quality of life (QoL) consequences of osteoporotic fractures...
December 11, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29230365/identification-and-characterization-of-a-novel-zebrafish-danio-rerio-pentraxin-carbonic-anhydrase
#7
Maarit S Patrikainen, Martti E E Tolvanen, Ashok Aspatwar, Harlan R Barker, Csaba Ortutay, Janne Jänis, Mikko Laitaoja, Vesa P Hytönen, Latifeh Azizi, Prajwol Manandhar, Edit Jáger, Daniela Vullo, Sampo Kukkurainen, Mika Hilvo, Claudiu T Supuran, Seppo Parkkila
Background: Carbonic anhydrases (CAs) are ubiquitous, essential enzymes which catalyze the conversion of carbon dioxide and water to bicarbonate and H+ ions. Vertebrate genomes generally contain gene loci for 15-21 different CA isoforms, three of which are enzymatically inactive. CA VI is the only secretory protein of the enzymatically active isoforms. We discovered that non-mammalian CA VI contains a C-terminal pentraxin (PTX) domain, a novel combination for both CAs and PTXs. Methods: We isolated and sequenced zebrafish (Danio rerio) CA VI cDNA, complete with the sequence coding for the PTX domain, and produced the recombinant CA VI-PTX protein...
2017: PeerJ
https://www.readbyqxmd.com/read/29229914/magnetostriction-polarization-coupling-in-multiferroic-mn2mnwo6
#8
Man-Rong Li, Emma E McCabe, Peter W Stephens, Mark Croft, Liam Collins, Sergei V Kalinin, Zheng Deng, Maria Retuerto, Arnab Sen Gupta, Haricharan Padmanabhan, Venkatraman Gopalan, Christoph P Grams, Joachim Hemberger, Fabio Orlandi, Pascal Manuel, Wen-Min Li, Chang-Qing Jin, David Walker, Martha Greenblatt
Double corundum-related polar magnets are promising materials for multiferroic and magnetoelectric applications in spintronics. However, their design and synthesis is a challenge, and magnetoelectric coupling has only been observed in Ni3TeO6 among the known double corundum compounds to date. Here we address the high-pressure synthesis of a new polar and antiferromagnetic corundum derivative Mn2MnWO6, which adopts the Ni3TeO6-type structure with low temperature first-order field-induced metamagnetic phase transitions (T N = 58 K) and high spontaneous polarization (~ 63...
December 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/29229909/pseudogap-phase-of-cuprate-superconductors-confined-by-fermi-surface-topology
#9
N Doiron-Leyraud, O Cyr-Choinière, S Badoux, A Ataei, C Collignon, A Gourgout, S Dufour-Beauséjour, F F Tafti, F Laliberté, M-E Boulanger, M Matusiak, D Graf, M Kim, J-S Zhou, N Momono, T Kurosawa, H Takagi, Louis Taillefer
The properties of cuprate high-temperature superconductors are largely shaped by competing phases whose nature is often a mystery. Chiefly among them is the pseudogap phase, which sets in at a doping p* that is material-dependent. What determines p* is currently an open question. Here we show that the pseudogap cannot open on an electron-like Fermi surface, and can only exist below the doping p FS at which the large Fermi surface goes from hole-like to electron-like, so that p* ≤ p FS. We derive this result from high-magnetic-field transport measurements in La1...
December 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/29229855/distinct-roles-of-n-and-o-glycans-in-cellulase-activity-and-stability
#10
Antonella Amore, Brandon C Knott, Nitin T Supekar, Asif Shajahan, Parastoo Azadi, Peng Zhao, Lance Wells, Jeffrey G Linger, Sarah E Hobdey, Todd A Vander Wall, Todd Shollenberger, John M Yarbrough, Zhongping Tan, Michael F Crowley, Michael E Himmel, Stephen R Decker, Gregg T Beckham, Larry E Taylor
In nature, many microbes secrete mixtures of glycoside hydrolases, oxidoreductases, and accessory enzymes to deconstruct polysaccharides and lignin in plants. These enzymes are often decorated with N- and O-glycosylation, the roles of which have been broadly attributed to protection from proteolysis, as the extracellular milieu is an aggressive environment. Glycosylation has been shown to sometimes affect activity, but these effects are not fully understood. Here, we examine N- and O-glycosylation on a model, multimodular glycoside hydrolase family 7 cellobiohydrolase (Cel7A), which exhibits an O-glycosylated carbohydrate-binding module (CBM) and an O-glycosylated linker connected to an N- and O-glycosylated catalytic domain (CD)-a domain architecture common to many biomass-degrading enzymes...
December 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29229651/in-situ-measurements-of-saturn-s-ionosphere-show-that-it-is-dynamic-and-interacts-with-the-rings
#11
J-E Wahlund, M W Morooka, L Z Hadid, A M Persoon, W M Farrell, D A Gurnett, G Hospodarsky, W S Kurth, S-Y Ye, D J Andrews, N J T Edberg, A I Eriksson, E Vigren
The ionized upper layer of Saturn's atmosphere, its ionosphere, provides a closure of currents mediated by the magnetic field to other electrically charged regions (e.g., rings) and hosts ion - molecule chemistry. In 2017, the Cassini spacecraft passed inside the planet's rings, allowing in situ measurements of the ionosphere. The Radio and Plasma Wave Science (RPWS) instrument detected a cold, dense and dynamic ionosphere at Saturn that interacts with the rings. Plasma densities reached up to 1000 cm-3 and electron temperatures were below 1160 K near closest approach...
December 11, 2017: Science
https://www.readbyqxmd.com/read/29229415/return-to-sports-after-tibial-tubercle-osteotomy-for-patellofemoral-pain-and-osteoarthritis
#12
Joseph N Liu, Hao-Hua Wu, Grant H Garcia, Irene L Kalbian, Sabrina M Strickland, Beth E Shubin Stein
PURPOSE: To determine the rate of return to sports and clinical outcomes after anteromedialization (AMZ) tibial tubercle osteotomy (TTO) for patients with patellofemoral pain and/or osteoarthritis. METHODS: This study is a retrospective case series of consecutive patients who underwent unilateral or staged bilateral AMZ TTO for a primary diagnosis of patellofemoral pain or arthritis. Included were all patients with minimum 1-year follow-up. The indication for surgery was failure of at least 6 months of nonoperative treatment...
December 8, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29229308/lymphocyte-dominant-encephalitis-and-meningitis-in-simian-immunodeficiency-virus-infected-macaques-receiving-antiretroviral-therapy
#13
Lisa M Mangus, Sarah E Beck, Suzanne E Queen, Samuel A Brill, Erin N Shirk, Kelly A Metcalf Pate, Dillon C Muth, Robert J Adams, Lucio Gama, Janice E Clements, Joseph L Mankowski
A retrospective neuropathologic review of 30 SIV-infected pigtailed macaques receiving combination antiretroviral therapy (cART) was conducted. Seventeen animals with lymphocyte-dominant inflammation in the brain and/or meninges that clearly was morphologically distinct from prototypic SIV encephalitis and human immunodeficiency virus encephalitis were identified. Central nervous system (CNS) infiltrates in cART-treated macaques primarily comprised CD20+ B cells and CD3+ T cells with fewer CD68+ macrophages...
December 5, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29228975/prediabetes-and-cardiovascular-complications-study-paccs-international-collaboration-4%C3%A2-years-summary-and-future-direction
#14
E U Nwose, R S Richards, P T Bwititi, E O Igumbor, E J Oshionwu, K Okolie, I C Onyia, A Pokhrel, P Gyawali, J N Okuzor, V M Oguoma, F W Gardiner, L Wang
OBJECTIVE: The prediabetes and cardiovascular complications studies proposes to develop a screening protocol for diabetes cardiovascular risk, and strategies for holistic management amongst others. Over 500 participants were recruited in the first 2 years of rural community research screening. Specific for this report, various published findings were reviewed. The objective is to summarize research outcomes and itemize limitations as they constitute basis of future directions. RESULTS: Affordability and availability are major confounding behavioural change wheel factors in the rural community...
December 11, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29228943/reconsidering-the-prognosis-of-major-depressive-disorder-across-diagnostic-boundaries-full-recovery-is-the-exception-rather-than-the-rule
#15
Judith Verduijn, Josine E Verhoeven, Yuri Milaneschi, Robert A Schoevers, Albert M van Hemert, Aartjan T F Beekman, Brenda W J H Penninx
BACKGROUND: Major depressive disorder (MDD) is often handled as an episodic and isolated disorder, resulting in an optimistic view about its prognosis. Herein, we test the idea that the prognosis of MDD changes if we vary the perspective in terms of (1) a longer time frame and (2) a broader diagnostic conceptualisation including dysthymia, (hypo)mania and anxiety disorders as relevant outcomes. METHODS: Patients with current MDD at baseline (n = 903) and available 2-, 4-, and/or 6-year follow-up assessments were selected from the Netherlands Study of Depression and Anxiety, a psychiatric cohort study...
December 12, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29228453/effects-of-erythropoietin-on-spontaneous-and-oxytocin-induced-myometrial-contractions-in-the-nonpregnant-rat
#16
N Tug, H Ayvaci Tasan, M A Sargin, B Dogan Taymur, A Ayar, E Kilic, B Yilmaz
OBJECTIVE: Erythropoietin (EPO) is a glycoprotein hormone that regulates erythropoiesis. EPO activity has also been detected in a variety of tissue including the nervous system, and female and male reproductive organs. It has been shown that EPO causes relaxation in vascular smooth muscle. In the present study, we have investigated effects of EPO on spontaneous and oxytocin-induced contractions of non-pregnant rat myometrium. MATERIALS AND METHODS: Myometrial stripes were obtained from adult Wistar rats at the oestrous stage...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29228211/asymmetry-of-post-mortem-neuropathology-in-behavioural-variant-frontotemporal-dementia
#17
David J Irwin, Corey T McMillan, Sharon X Xie, Katya Rascovsky, Vivianna M Van Deerlin, H Branch Coslett, Roy Hamilton, Geoffrey Aguirre, Edward B Lee, Virginia M Y Lee, John Q Trojanowski, Murray Grossman
Antemortem behavioural and anatomic abnormalities have largely been associated with right hemisphere disease in behavioural-variant frontotemporal dementia, but post-mortem neuropathological examination of bilateral hemispheres remains to be defined. Here we measured the severity of post-mortem pathology in both grey and white matter using a validated digital image analysis method in four cortical regions sampled from each hemisphere in 26 patients with behavioural-variant frontotemporal dementia, including those with frontotemporal degeneration (i...
December 8, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29228087/analysis-of-angiogenesis-biomarkers-for-ramucirumab-efficacy-in-patients-with-metastatic-colorectal-cancer-from-raise-a-global-randomized-double-blind-phase-iii-study
#18
J Tabernero, R R Hozak, T Yoshino, A L Cohn, R Obermannova, G Bodoky, R Garcia-Carbonero, T-E Ciuleanu, D C Portnoy, J Prausová, K Muro, R W Siegel, R J Konrad, H Ouyang, S A Melemed, D Ferry, F Nasroulah, E Van Cutsem
Background: The phase III RAISE trial (NCT01183780) demonstrated that the vascular endothelial growth factor (VEGF) receptor (VEGFR)-2 binding monoclonal antibody ramucirumab plus 5-fluororuracil, leucovorin, and irinotecan (FOLFIRI) significantly improved overall survival (OS) and progression-free survival (PFS) compared with placebo+FOLFIRI as second-line metastatic colorectal cancer (mCRC) treatment. To identify patients who benefit the most from VEGFR-2 blockade, the RAISE trial design included a prospective and comprehensive biomarker program that assessed the association of biomarkers with ramucirumab efficacy outcomes...
December 7, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29227914/design-and-use-of-a-folded-four-ring-double-tuned-birdcage-coil-for-rat-brain-sodium-imaging-at-9-4%C3%A2-t
#19
YongHyun Ha, Chang-Hoon Choi, Wieland A Worthoff, Aliaksandra Shymanskaya, Michael Schöneck, Antje Willuweit, Jörg Felder, N Jon Shah
A folded four-ring quadrature birdcage coil was designed and constructed with a double-tune configuration of an outer high-pass coil for 1H (400 MHz) and inner low-pass coil for 23Na (105.72 MHz at 9.4 T). The coil was evaluated on the bench and in the scanner, comparing its performance with that of single-tuned coils and a large four-ring coil. All coils were tuned and matched and the isolation between two quadrature ports was found to be better than -13.7 dB for 1H and -27 dB for 23Na. Signal-to-noise ratios (SNRs) were calculated and 23Na flip angle maps were acquired...
December 6, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/29227838/financial-strain-indirectly-influences-smoking-cessation-through-withdrawal-symptom-severity
#20
Darla E Kendzor, Michael S Businelle, Aaron F Waters, Summer G Frank, Emily T Hébert
BACKGROUND: Financial strain has an adverse impact on smoking cessation. However, the mechanisms through which financial strain influences cessation remain unclear. The purpose of the current study was to determine whether financial strain indirectly influenced smoking cessation through withdrawal symptom severity. METHODS: Participants (N=139) were primarily Black (63.3%) and female (57.6%) adults enrolled in a smoking cessation program at a safety-net hospital...
December 8, 2017: Drug and Alcohol Dependence
keyword
keyword
25415
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"