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https://www.readbyqxmd.com/read/29055209/long-term-survival-of-sorafenib-treated-flt3-itd-positive-acute-myeloid-leukaemia-patients-relapsing%C3%A2-after-allogeneic-stem-cell-transplantation
#1
S K Metzelder, T Schroeder, M Lübbert, M Ditschkowski, K Götze, S Scholl, R G Meyer, P Dreger, N Basara, M F Fey, H R Salih, A Finck, T Pabst, A Giagounidis, G Kobbe, E Wollmer, J Finke, A Neubauer, A Burchert
BACKGROUND: Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD)-positive acute myeloid leukaemia (AML) relapsing after allogeneic stem cell transplantation (allo-SCT) has a dismal prognosis with limited therapeutic options. FLT3-ITD kinase inhibition is a reasonable but palliative experimental treatment alternative in this situation. Information on long-term outcome is not available. METHODS: We performed a long-term follow-up analysis of a previously reported cohort of 29 FLT3-ITD-positive AML patients, which were treated in relapse after allo-SCT with sorafenib monotherapy...
October 18, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29055208/measuring-alcohol-use-across-the-transition-to-adulthood-racial-ethnic-sexual-identity-and-educational-differences
#2
Jessica N Fish, Amanda M Pollitt, John E Schulenberg, Stephen T Russell
BACKGROUND: Patterns of alcohol use change from adolescence to adulthood and may differ based on race/ethnicity, sexual identity, and education. If alcohol use measures do not operate consistently across groups and developmental periods, parameter estimates and conclusions may be biased. OBJECTIVES: To test the measurement invariance of a multi-item alcohol use measure across groups defined by race/ethnicity, sexual identity, and college education during the transition to adulthood...
October 12, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29055142/the-fate-of-the-bone-graft-in-cerebrospinal-fluid-rhinorrhea-endoscopic-repair-for-idiopathic-intracranial-hypertension-a-retrospective-case-series-analysis
#3
A D Workman, R M Carey, A K Parasher, E C Kuan, J Godovchik, J T Glicksman, D W Kennedy, J N Palmer, N D Adappa
INTRODUCTION: Idiopathic intracranial hypertension (IIH) is a common cause of spontaneous cerebrospinal fluid (CSF) leaks necessitating surgical intervention, and grafting of septal, mastoid, or turbinate bone over the defect is increasingly performed to strengthen the repair of the primary defect. However, the postoperative fate of these grafted bone fragments is largely unknown. METHODOLOGY: We performed a retrospective study of patients at the University of Pennsylvania undergoing repair of spontaneous CSF leaks secondary to IIH...
October 21, 2017: Rhinology
https://www.readbyqxmd.com/read/29055135/treatment-of-prurigo-with-methotrexate-a-multicenter-retrospective-study-of-39-cases-running-head-treatment-of-prurigo-with-methotrexate
#4
T Klejtman, M Beylot-Barry, P Joly, M A Richard, S Debarbieux, L Misery, P Wolkenstein, O Chosidow, S Ingen-Housz-Oro
BACKGROUND: Prurigo is a common primary pruritic condition. Treatment is challenging. Methotrexate (MTX) is effective for the treatment of pruriginous dermatoses, but its use in prurigo has been little studied. OBJECTIVES: To investigate the efficacy and safety of MTX in the treatment of difficult-to-treat prurigo. METHODS: Patients from six university dermatology departments treated with MTX between 2006 and 2016 for difficult-to-treat prurigo (i...
October 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29054833/pregnant-women-s-perceptions-of-the-risks-and-benefits-of-disclosure-during-web-based-mental-health-e-screening-versus-paper-based-screening-randomized-controlled-trial
#5
Dawn Kingston, Anne Biringer, Sander Veldhuyzen van Zanten, Rebecca Giallo, Sarah McDonald, Glenda MacQueen, Lydia Vermeyden, Marie-Paule Austin
BACKGROUND: Pregnant women's perceptions of the risks and benefits during mental health screening impact their willingness to disclose concerns. Early research in violence screening suggests that such perceptions may vary by mode of screening, whereby women view the anonymity of e-screening as less risky than other approaches. Understanding whether mode of screening influences perceptions of risk and benefit of disclosure is important in screening implementation. OBJECTIVE: The objective of this randomized controlled trial was to compare the perceptions of pregnant women randomized to a Web-based screening intervention group and a paper-based screening control group on the level of risk and benefit they perceive in disclosing mental health concerns to their prenatal care provider...
October 20, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/29054767/identifying-eustachian-tube-dysfunction-prior-to-hyperbaric-oxygen-therapy-who-is-at-risk-for-intolerance
#6
Jason E Cohn, Michael Pfeiffer, Niki Patel, Robert T Sataloff, Brian J McKinnon
PURPOSE: Determine whether specific risk factors, symptoms and clinical examination findings are associated with hyperbaric oxygen therapy (HBOT) intolerance and subsequent tympanotomy tube placement. MATERIALS AND METHODS: A retrospective case series with chart review was conducted from 2007 to 2016 of patients undergoing HBOT clearance at a tertiary care university hospital in an urban city. Eighty-one (n=81) patient charts were reviewed for risk factors, symptoms and clinical examination findings related to HBOT eustachian tube dysfunction and middle ear barotrauma...
October 10, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29054728/a-novel-multi-variant-epitope-ensemble-vaccine-against-avian-leukosis-virus-subgroup-j
#7
Xiaoyu Wang, Defang Zhou, Guihua Wang, Libo Huang, Qiankun Zheng, Chengui Li, Ziqiang Cheng
The hypervariable antigenicity and immunosuppressive features of avian leukosis virus subgroup J (ALV-J) has led to great challenges to develop effective vaccines. Epitope vaccine will be a perspective trend. Previously, we identified a variant antigenic neutralizing epitope in hypervariable region 1 (hr1) of ALV-J, N-LRDFIA/E/TKWKS/GDDL/HLIRPYVNQS-C. BLAST analysis showed that the mutation of A, E, T and H in this epitope cover 79% of all ALV-J strains. Base on this data, we designed a multi-variant epitope ensemble vaccine comprising the four mutation variants linked with glycine and serine...
October 17, 2017: Vaccine
https://www.readbyqxmd.com/read/29054589/baseline-asthma-burden-comorbidities-and-biomarkers-in-omalizumab-treated-patients-in-prospero
#8
Bradley E Chipps, Robert S Zeiger, Allan T Luskin, William W Busse, Benjamin L Trzaskoma, Evgeniya N Antonova, Hooman Pazwash, Susan L Limb, Paul G Solari, Noelle M Griffin, Thomas B Casale
BACKGROUND: Patients included in clinical trials do not necessarily reflect the real-world population. OBJECTIVE: To understand the characteristics, including disease and comorbidity burden, of patients with asthma receiving omalizumab in a real-world setting. METHODS: The Prospective Observational Study to Evaluate Predictors of Clinical Effectiveness in Response to Omalizumab (PROSPERO) was a US-based, multicenter, single-arm, and prospective study...
October 17, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29054487/patterns-of-self-care-and-clinical-events-in-a-cohort-of-adults-with-heart-failure-1-year-follow-up
#9
Christopher S Lee, Julie T Bidwell, Marco Paturzo, Rosaria Alvaro, Antonello Cocchieri, Tiny Jaarsma, Anna Strömberg, Barbara Riegel, Ercole Vellone
BACKGROUND: Heart failure (HF) self-care is important in reducing clinical events (all-cause mortality, emergency room visits and hospitalizations). HF self-care behaviors are multidimensional and include maintenance (i.e. daily adherence behaviors), management (i.e. symptom response behaviors) and consulting behaviors (i.e. contacting a provider when appropriate). Across these dimensions, patterns of successful patient engagement in self-care have been observed (e.g. successful in one dimension but not in others), but no previous studies have linked patterns of HF self-care to clinical events...
October 17, 2017: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/29054425/molecular-characterization-of-congenital-myasthenic-syndromes-in-spain
#10
D Natera-de Benito, A Töpf, J J Vilchez, L González-Quereda, J Domínguez-Carral, J Díaz-Manera, C Ortez, M Bestué, P Gallano, M Dusl, A Abicht, J S Müller, J Senderek, A García-Ribes, N Muelas, T Evangelista, Y Azuma, G McMacken, A Paipa Merchan, P M Rodríguez Cruz, A Camacho, E Jiménez, M C Miranda-Herrero, A Santana-Artiles, O García-Campos, R Dominguez-Rubio, M Olivé, J Colomer, D Beeson, H Lochmüller, A Nascimento
Congenital myasthenic syndromes (CMS) are a heterogeneous group of genetic disorders, all of which impair neuromuscular transmission. Epidemiological data and frequencies of gene mutations are scarce in the literature. Here we describe the molecular genetic and clinical findings of sixty-four genetically confirmed CMS patients from Spain. Thirty-six mutations in the CHRNE, RAPSN, COLQ, GFPT1, DOK7, CHRNG, GMPPB, CHAT, CHRNA1, and CHRNB1 genes were identified in our patients, with five of them not reported so far...
August 18, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/29053918/active-site-interactions-impact-phosphoryl-transfer-during-replication-of-damaged-and-undamaged-dna-by-escherichia-coli-dna-polymerase-i
#11
A S Prakasha Gowda, Thomas E Spratt
Replicative DNA polymerases are able to discriminate between very similar substrates with high accuracy. One mechanism by which Escherichia coli DNA polymerase I checks for Watson-Crick geometry is through a hydrogen bonding fork between Arg668 and the incoming dNTP and the minor groove of the primer terminus. The importance of the Arg-fork was examined by disrupting it with either a guanine to 3-deazaguanine substitution at the primer terminus or the use of a carbocyclic deoxyribose analog of dUTP. Using thio-substituted dNTPs and differential quench techniques, we determined that when the Arg-fork was disrupted, the rate limiting step changed from a conformational change to phosphodiester bond formation...
October 20, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29053874/tau-pathology-and-neurodegeneration-contribute-to-cognitive-impairment-in-alzheimer-s-disease
#12
Alexandre Bejanin, Daniel R Schonhaut, Renaud La Joie, Joel H Kramer, Suzanne L Baker, Natasha Sosa, Nagehan Ayakta, Averill Cantwell, Mustafa Janabi, Mariella Lauriola, James P O'Neil, Maria L Gorno-Tempini, Zachary A Miller, Howard J Rosen, Bruce L Miller, William J Jagust, Gil D Rabinovici
Neuropathological and in vivo studies have revealed a tight relationship between tau pathology and cognitive impairment across the Alzheimer's disease spectrum. However, tau pathology is also intimately associated with neurodegeneration and amyloid pathology. The aim of the present study was therefore to assess whether grey matter atrophy and amyloid pathology contribute to the relationship between tau pathology, as measured with 18F-AV-1451-PET imaging, and cognitive deficits in Alzheimer's disease. We included 40 amyloid-positive patients meeting criteria for mild cognitive impairment due to Alzheimer's disease (n = 5) or probable Alzheimer's disease dementia (n = 35)...
October 7, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053868/lagos-ne-a-multi-scaled-geospatial-and-temporal-database-of-lake-ecological-context-and-water-quality-for-thousands-of-u-s-lakes
#13
Patricia A Soranno, Linda C Bacon, Michael Beauchene, Karen E Bednar, Edward G Bissell, Claire K Boudreau, Marvin G Boyer, Mary T Bremigan, Stephen R Carpenter, Jamie W Carr, Kendra S Cheruvelil, Samuel T Christel, Matt Claucherty, Sarah M Collins, Joseph D Conroy, John A Downing, Jed Dukett, C Emi Fergus, Christopher T Filstrup, Clara Funk, Maria J Gonzalez, Linda T Green, Corinna Gries, John D Halfman, Stephen K Hamilton, Paul C Hanson, Emily N Henry, Elizabeth M Herron, Celeste Hockings, James R Jackson, Kari Jacobson-Hedin, Lorraine L Janus, William W Jones, John R Jones, Caroline M Keson, Katelyn B S King, Scott A Kishbaugh, Jean-Francois Lapierre, Barbara Lathrop, Jo A Latimore, Yuehlin Lee, Noah R Lottig, Jason A Lynch, Leslie J Matthews, William H McDowell, Karen E B Moore, Brian P Neff, Sarah J Nelson, Samantha K Oliver, Michael L Pace, Donald C Pierson, Autumn C Poisson, Amina I Pollard, David M Post, Paul O Reyes, Donald O Rosenberry, Karen M Roy, Lars G Rudstam, Orlando Sarnelle, Nancy J Schuldt, Caren E Scott, Nicholas K Skaff, Nicole J Smith, Nick R Spinelli, Joseph J Stachelek, Emily H Stanley, John L Stoddard, Scott B Stopyak, Craig A Stow, Jason M Tallant, Pang-Ning Tan, Anthony P Thorpe, Michael J Vanni, Tyler Wagner, Gretchen Watkins, Kathleen C Weathers, Katherine E Webster, Jeffrey D White, Marcy K Wilmes, Shuai Yuan
Background: Understanding the factors that affect water quality and the ecological services provided by freshwater ecosystems is an urgent global environmental issue. Predicting how water quality will respond to global changes not only requires water quality data, but also information about the ecological context of individual water bodies across broad spatial extents. Because lake water quality is usually sampled in limited geographic regions, often for limited time periods, assessing the environmental controls of water quality requires compilation of many datasets across broad regions and across time into an integrated database...
October 19, 2017: GigaScience
https://www.readbyqxmd.com/read/29053820/mood-disorders-and-risk-of-herpes-zoster-in-two-population-based-case-control-studies-in-denmark-and-the-united-kingdom
#14
Sigrun A J Schmidt, Sinéad M Langan, Henrik S Pedersen, Henrik C Schønheyder, Sara L Thomas, Liam Smeeth, Kathryn E Mansfield, Henrik T Sørensen, Harriet J Forbes, Mogens Vestergaard
We examined the association between mood disorders and risk of herpes zoster in two case-control studies using data from nationwide Danish registries and practices in the UK Clinical Practice Research Datalink. We included incident zoster cases diagnosed in general practice (using systemic antivirals as proxy in Denmark) or hospital during 1997-2013 in Denmark (n = 190,671) and during 2000-2013 in the UK (n = 177,361). We risk-set sampled four matched population controls per case. Conditional logistic regression analyses adjusted for zoster risk factors showed that the odds ratios (ORs) for previous mood disorder among cases vs...
October 19, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29053815/insulin-immuno-neutralization-decreases-food-intake-in-chickens-without-altering-hypothalamic-transcripts-involved-in-food-intake-and-metabolism
#15
M Proszkowiec-Weglarz, J Dupont, N Rideau, C Gespach, J Simon, T E Porter
In mammals, insulin regulates blood glucose levels and plays a key regulatory role in appetite via the hypothalamus. In contrast, chickens are characterized by atypical glucose homeostasis, with relatively high blood glucose levels, reduced glucose sensitivity of pancreatic beta cells, and large resistance to exogenous insulin. The aim of the present study was to investigate in chickens the effects of 5 h fasting and 5 h insulin immuno-neutralization on hypothalamic mRNA levels of 23 genes associated with food intake, energy balance, and glucose metabolism...
September 20, 2017: Poultry Science
https://www.readbyqxmd.com/read/29053812/efficacy-of-feed-additives-to-reduce-the-effect-of-naturally-occurring-mycotoxins-fed-to-turkey-hen-poults-reared-to-6-weeks-of-age
#16
J E N Tilley, J L Grimes, M D Koci, R A Ali, C R Stark, P K Nighot, T F Middleton, A C Fahrenholz
Corn with naturally occurring aflatoxin (AF), wheat with naturally occurring doxynivalenol (DON), and barley with naturally occurring zearalenone (ZEA) were used to make rations for feeding turkey hen poults to 6 weeks of age. Control rations with equal amounts of corn, wheat, and barley were also fed. The control rations did contain some DON while both sets of rations contained ZEA. Within each grain source, there were 4 treatments: the control ration plus 3 rations each with a different feed additive which were evaluated for the potential to lessen potential mycotoxin effects on bird performance and physiology...
September 20, 2017: Poultry Science
https://www.readbyqxmd.com/read/29053797/genotype-phenotype-correlation-in-atad3a-deletions-not-just-of-scientific-relevance
#17
Cacha M P C D Peeters-Scholte, Phebe N Adama van Scheltema, Frans J C M Klumper, Sheila M P Everwijn, Marije Koopmans, Mariette J V Hoffer, Tamara T Koopmann, Claudia A L Ruivenkamp, Sylke J Steggerda, Marjo S van der Knaap, Gijs W E Santen
No abstract text is available yet for this article.
October 6, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053737/screening-for-hiv-hepatitis-b-and-syphilis-on-dried-blood-spots-a-promising-method-to-better-reach-hidden-high-risk-populations-with-self-collected-sampling
#18
Inge H M van Loo, Nicole H T M Dukers-Muijrers, Rosalie Heuts, Marianne A B van der Sande, Christian J P A Hoebe
INTRODUCTION: Many people at high risk for sexually transmitted infections (STIs), e.g., men who have sex with men (MSM), are not optimally reached by current sexual health care systems with testing. To facilitate testing by home-based sampling or sampling in outreach setting we evaluated dried blood spots (DBS), a method for self-collected blood sampling for serological screening of HIV, hepatitis B (HBV) and syphilis. The aims of this study were to assess the acceptability and feasibility of self-collected DBS and to compare the test results for screening of HIV, HBV and syphilis from DBS with blood drawn by venous puncture...
2017: PloS One
https://www.readbyqxmd.com/read/29053542/biomechanical-comparison-of-intrapelvic-and-extrapelvic-fixation-for-acetabular-fractures-involving-the-quadrilateral-plate
#19
Gregory J Gillispie, Sharon N Babcock, Kyle P McNamara, Michaela E Dimoff, Arun Aneja, Philip J Brown, Eben A Carroll
OBJECTIVES: Elderly patients represent the fastest growing and most difficult to treat population sustaining acetabular fractures. When treated surgically, isolated extrapelvic or combined intrapelvic-extrapelvic constructs may be used. No biomechanical or clinical study has compared the merits of these 2 techniques in cadaveric models. This research aims to biomechanically quantify the additional benefit of intrapelvic fixation to a standard extrapelvic fixation construct. METHODS: Ten cadaveric pelves underwent standardized anterior column and quadrilateral plate fracture creation...
November 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29053389/mrpl53-a-new-candidate-gene-for-orofacial-clefting-identified-using-an-eqtl-approach
#20
C Masotti, L A Brito, A C Nica, K U Ludwig, K Nunes, C P Savastano, C Malcher, S G Ferreira, G S Kobayashi, D F Bueno, N Alonso, D Franco, A Rojas-Martinez, S E Dos Santos, P A Galante, D Meyer, T Hünemeier, E Mangold, E T Dermitzakis, M R Passos-Bueno
A valuable approach to understand how individual and population genetic differences can predispose to disease is to assess the impact of genetic variants on cellular functions (e.g., gene expression) of cell and tissue types related to pathological states. To understand the genetic basis of nonsyndromic cleft lip with or without cleft palate (NSCL/P) susceptibility, a complex and highly prevalent congenital malformation, we searched for genetic variants with a regulatory role in a disease-related tissue, the lip muscle (orbicularis oris muscle [OOM]), of affected individuals...
October 1, 2017: Journal of Dental Research
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