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Hypophysis tumors

Bruno Law-Ye, Clément Cholet, Delphine Leclercq
Pituicytomas are rare low-grade glial lesions of neurohypophysis or adenohypophysis. They are often misdiagnosed as adenomas due to their similar morphology. Previous reports have underlined their non specific aspect. In our experience, presence of flow voids on MR, which usually indicate hypervascularized tumors with strong arterial supply, may be a useful sign to identify pituicytomas. Unlike adenomas, pituicytomas are highly vascularized tumors. Second, we emphasize the strong enhancement of these tumors when compared to normal hypophysis, which may be another sign of the their hypervascularization...
October 14, 2017: World Neurosurgery
Guang-Zhi Yang, Jing Li
Granular cell tumor (GCT) rarely involves the central nervous system, and fewer than 100 cases have been reported in English literatures. We herein report a case of a 36-year-old Chinese man with GCT of the neurohypophysis. Magnetic resonance imaging showed one mass located in the hypophysis with heterogeneous contrast enhancement. Pathological examination showed a neoplasm comprising densely packed polygonal cells of ample cytoplasm with abundant eosinophilic granules inside. The nuclei were small with inconspicuous nucleoli and yet without any mitoses...
June 1, 2017: International Journal of Surgical Pathology
José M Pascual, Lorenzo Mongardi, Ruth Prieto, Inés Castro-Dufourny, María Rosdolsky, Sewan Strauss, Rodrigo Carrasco, Eduard Winter, Paolo Mazzarello
The field of pituitary surgery was born in the first decade of the twentieth century in Europe, and it evolved rapidly with the development of numerous innovative surgical techniques by some of the founding fathers of neurosurgery. This study investigates the pioneering Italian treatise on pituitary surgery, La Patologia Chirurgica dell'Ipofisi (Surgical Pathology of the Hypophysis), published in 1911 by Giovanni Verga (1879-1923), a surgeon from Pavía and one of Golgi's disciples. This little-known monograph compiles the earliest experience on pituitary surgery through the analysis of the first 50 procedures performed between 1903 and 1911...
October 2017: Neurosurgical Review
Xiao Wu, Xiaoqiang Liang, Yijie DU, Yan Zhang, Meng Yang, Weiyi Gong, Baojun Liu, Jingcheng Dong, Ningxia Zhang, Hongying Zhang
The aim of the study was to examine the mechanism of action of Lidan Granule (LDG) for the prevention of gallstones using a guinea pig model. One hundred guinea pigs were divided into five groups randomly: control (standard diet and saline), model [lithogenic diet (LD) and saline], LDG-H (LD and 2 g/kg of LDG), LDG-L (LD and 1 g/kg of LDG), and ursodeoxycholic acid (UDCA) (LD and UDCA) as the positive control. At 6 weeks, the rate of gallstone formation and weight of the adrenal gland were recorded and serum levels of inflammatory cytokines were measured...
July 2016: Biomedical Reports
Fabio Rotondo, Henriett Butz, Luis V Syro, George M Yousef, Antonio Di Ieva, Lina M Restrepo, Andres Quintanar-Stephano, Istvan Berczi, Kalman Kovacs
INTRODUCTION: This publication reviews the function of arginine vasopressin and focuses on the morphologic and functional correlation between the hormone and its effect on stress, the hypophysial-adrenocortical axis, neuroimmune responses, renal function and corticotroph pituitary tumors. MATERIALS AND METHODS: A literature review was performed using various search engines for information regarding the morphology and the multifunctional role of arginine vasopressin...
August 2016: Pituitary
Mesut Ozkaya, Zeynel Abidin Sayiner, Gurkan Kiran, Kamile Gul, Ibrahim Erkutlu, Umut Elboga
Acromegaly is a clinical syndrome caused by the overproduction of growth hormone (GH) and also known as a rare disease. Clinical, biochemical, and radiological features are often indistinguishable between GH-producing hypophysis adenomas and ectopic GH-releasing hormone (GHRH)-producing tumors. A 40-year-old woman presented to us with her growing feet, hands especially fingers, and enlarging nose. Biochemical diagnosis of acromegaly was made by measuring insulin-like growth factor-1 (IGF-1) level and glucose-suppressed GH estimation...
June 2015: Wiener Klinische Wochenschrift
César Esteves, Celestino Neves, Luís Augusto, Joana Menezes, Josué Pereira, Irene Bernardes, José Fonseca, Davide Carvalho
PURPOSE: Most pituitary lesions are detected during the investigation of symptoms associated with hormonal dysfunction and vision abnormalities. When the lesion is identified in an image performed for reasons not related to the tumor, the term incidentaloma applies. Our aim was to describe the diagnosis behind pituitary incidentalomas, patient characteristics and their follow up. METHODS: We searched for the terms "pituitary", "hypophysis" and "incidentaloma" in the requisitions and reports of all CTs and MRIs performed between 1st September 2008 and 30th October 2013...
December 2015: Pituitary
José M Pascual, Ruth Prieto, Paolo Mazzarello
Sir Victor Horsley (1857-1916) is considered to be the pioneer of pituitary surgery. He is known to have performed the first surgical operation on the pituitary gland in 1889, and in 1906 he stated that he had operated on 10 patients with pituitary tumors. He did not publish the details of these procedures nor did he provide evidence of the pathology of the pituitary lesions operated on. Four of the patients underwent surgery at the National Hospital for Neurology and Neurosurgery (Queen Square, London), and the records of those cases were recently retrieved and analyzed by members of the hospital staff...
July 2015: Journal of Neurosurgery
Inés Castro-Dufourny, Rodrigo Carrasco, Ruth Prieto, Laura Barrios, José M Pascual
PURPOSE: Infundibulo-tuberal syndrome groups endocrine, metabolic and behavioral disturbances caused by lesions involving the upper neurohypophysis (median eminence) and adjacent basal hypothalamus (tuber cinereum). It was originally described by Henri Claude and Jean Lhermitte in 1917, in a patient with a craniopharyngioma. This study investigates the clinical, pathological and surgical evidence verifying the infundibulo-tuberal syndrome caused by craniopharyngiomas (CPs). METHODS: A systematic retrospective review of craniopharyngiomas reported in French literature between 1705 and 1973 was conducted...
October 2015: Pituitary
Min Liu, Juan Du, Yanmei Sang, Yujun Wu, Jie Yan, Cheng Zhu
AIM: To investigate the etiology and clinical characteristics of hypothalamic syndrome in Chinese children. METHODS: Thirty-three cases of hypothalamic syndrome were analyzed for etiology, initial symptoms, and clinical characteristics. RESULTS: All of the 33 patients manifested symptoms of hypothalamic dysfunction and disorders of the hypothalamus-hypophysis-target gland axis. Fourteen patients were diagnosed with an intracranial tumor by magnetic resonance imaging (MRI) examination, four patients had postoperative intracranial tumors, one had received radiotherapy for suprasellar germinoma, one was hypothalamic-pituitary dysplasia, one had a history of viral encephalitis, and in 12 patients, the cause was unknown...
March 2014: Journal of Pediatric Endocrinology & Metabolism: JPEM
O M Vozniak, O V Maĭdannyk
Experience of rational combined application of microscope or endoscope while excision of giant adenomas of the hypophysis (GAH), using transsphenoidal approach, was summarized. Of 87 patients, operated for GAH during last 5 yrs, 34--were operated with combined application of operative microscope and endoscope. Convenience for surgeon, traumaticity and efficacy, chronometry of surgical interventions were estimated. In 12 patients a complete excision of GAH was achieved, in 18--almost complete (90% and more), in 4--subtotal (range 70 - 90%)...
December 2013: Klinichna Khirurhiia
O M Vozniak, O V Maĭdannyk
The issues of practical application of neuronavigation in surgical treatment of giant adenomas of the hypophysis (GAH), using transsphenoidal approach, were addressed. Surgical treatment, using neuronavigation system (NNS) "Brainlab Curve Dual Display" (Germany), was performed in 12 patients, suffering GAH. In all the observation a transnasal transsphenoidal access was applied. Radical tumoral excision was achieved in 3 patients, almost complete excision (90% of the tumor volume and more)--in 5, subtotal (70 - 90%)--in 4...
November 2013: Klinichna Khirurhiia
Theodoros Thomas, Steffen Zender, Christoph Terkamp, Elmar Jaeckel, Michael P Manns
BACKGROUND: Adrenocorticotropic hormone-producing extraadrenal paragangliomas are extremely rare. We present a case of severe hypercortisolemia due to ectopic adrenocorticotropic hormone secretion by a nasal paraganglioma. CASE PRESENTATION: A 70-year-old Caucasian woman, was emergently admitted to our department with supraventricular tachycardia, oedema of face and extremities and hypertensive crisis. Initial laboratory evaluation revealed severe hypokalemia and hyperglycemia without ketoacidosis, although no diabetes mellitus was previously known...
August 19, 2013: BMC Research Notes
Antonio Di Ieva, Andrea Weckman, Joseph Di Michele, Fabio Rotondo, Fabio Grizzi, Kalman Kovacs, Michael D Cusimano
The idea that microvasculature might be a histopathological biomarker in the prognosis and treatment of tumors is garnering even more attention in the scientific community. The roles of neovascularity in tumor progression and metastasis, have become a hot-topic of investigation in cancer research. A number of methods of quantitatively analyzing pituitary adenoma microvasculature have been applied, and fractal analysis is emerging as a potential effective model for this aim. Additionally, new and more specific immunological techniques have been developed for the detection of microvessels...
September 2013: Microvascular Research
Jialiang Li, Changming Zhang, Jibing Chen, Fei Yao, Jianying Zeng, Liwen Huang, Xiuli Yang, Weiqun Liu, Feng Chen, Keqiang Xu, Daming Yang, Lizhi Niu, Jiansheng Zuo, Kecheng Xu, DePei Liu
We report 2 cases of familial multiple endocrine neoplasia type 1 syndrome (MEN 1) in related Malaysian Chinese individuals: the son had simultaneous primary lesions in the pancreatic tail, parathyroid, adrenal gland, and hypophysis, with metastatic tumors in the left lung, mediastinum and spine; his mother had simultaneous primary lesions in the pancreatic head, parathyroid, and hypophysis, with metastatic tumors in the liver, spine, ilium, chest wall, and rib. Genetic testing of the 2 patients showed the same mutation in exon 9 of MEN1 (c...
March 2013: Pancreas
L M Abdullaeva, G S Babadzhanova, D B Nazarova, N D Muratova, U A Ashurova
The article presents hormonal analysis of hypothalamus-hypophysis-ovaries system of 14 patients with sterility as well as of other 15 patients without sterility suffering from benign tumors or tumorous formations. The control group included 6 healthy women. The concentration of hormones in blood serum (FSH-follicle stimulating hormone, LH-lutein hormone, Prolactinum, Testosteronum, Oestradiolum, Progesterone) has been tested in dynamics of a menstrual cycle. Correlation of results of hormonal and histological analysis of a capsule of formation and a biopsy of a tissue of an ovary of these patients has revealed that formation occurrence irrespective of its histological type leads to suppression of the follicular apparatus...
April 2012: Likars'ka Sprava
Jia Min, Fo-Quan Luo, Wei-Lu Zhao
BACKGROUND: Clara cell secretory protein (CC16) is an important lung derived protective factor and may play an important role on the pathogenesis of acute lung injury (ALI) induced by endotoxemia. Growth hormone (GH) is an important anabolism hormone secreted by GH cells of the hypophysis. Previous research showed that GH would significantly exacerbate ALI induced by endotoxemia, but the mechanism is not very clear yet. Whether the effects are related to CC16 or not is undetermined. METHODS: One hundred and twelve male Sprague-Dawley rats were randomly divided into an ALI group and a GH group...
August 2012: Chinese Medical Journal
I P Erko, V V Vasilinchuk, A A Moloshok, I D Sarhosh
No abstract text is available yet for this article.
March 2012: Klinichna Khirurhiia
Nestoras Mathioudakis, Alfredo Quinones-Hinojosa, Roberto Salvatori, Shehzad Basaria
Pituitary adenomas are the most common cause of a sellar mass. Metastases to the pituitary gland, a rare occurrence, may mimic benign pituitary adenomas. We report here a case of a 61-year-old woman with an 80-pack-year smoking history who presented with headache and diplopia. Visual field testing demonstrated bitemporal hemianopsia. Pituitary MRI revealed a 2.0 cm sellar mass impinging upon the optic chiasm. Hypopituitarism was present, with no evidence of diabetes insipidus. The patient was referred to our service for transsphenoidal resection of a presumed pituitary macroadenoma...
2012: Case Reports in Medicine
Sachiyo Maki, Akira Takakura, Yasuhiro Hiyoshi, Masanori Yokoba, Noriyuki Masuda, Masato Katagiri
A 62-year-old Japanese man visited our hospital for the examination of a middle-posterior mediastinal lesion noted on a chest CT image. Magnetic resonance imaging (MRI) showed swelling of the hypophysis, bilateral orbital muscles and bilateral lacrimal and submandibular glands. CT subsequently showed a middle-posterior mediastinal lesion, centrilobular nodules in the lung fields, swelling of the pulmonary hilar lymph nodes and soft tissue tumor around the bilateral ureteropelvic junctions. The patient's serum IgG4 level was elevated, and biopsy specimens from the lacrimal gland showed abundant IgG4-positive plasma cells...
December 2011: Nihon Kokyūki Gakkai Zasshi, the Journal of the Japanese Respiratory Society
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