keyword
https://read.qxmd.com/read/38544634/a-case-report-and-literature-review-of-skeletal-muscle-metastasis-of-non-small-cell-lung-cancer
#1
Linda Youn, Mirra Srinivasan, Amber Kuta, Jacyln Barnard, Mazen Khalil
Non-small cell lung cancer metastasis to skeletal muscle is an uncommon occurrence. Lung cancers are more likely to spread to the brain, bone, liver, and adrenals. Here, we present a rare case of non-small cell lung cancer metastasis to the skeletal muscle in a 54-year-old male. In addition, we present a literature review on skeletal metastasis of non-small cell lung cancer. The most frequent presentation of skeletal muscle metastasis is muscular pain with or without swelling. The mechanism of metastasis to muscle is not well understood; it is theorized that hematogenous spread is the most likely route...
February 2024: Curēus
https://read.qxmd.com/read/38542355/protecting-the-brain-novel-strategies-for-preventing-breast-cancer-brain-metastases-through-selective-estrogen-receptor-%C3%AE-agonists-and-in-vitro-blood-brain-barrier-models
#2
JOURNAL ARTICLE
Janine Kirchner, Elisabeth Völker, Sergey Shityakov, Shigehira Saji, Carola Y Förster
Breast cancer brain metastasis (BCBM) is a challenging condition with limited treatment options and poor prognosis. Understanding the interactions between tumor cells and the blood-brain barrier (BBB) is critical for developing novel therapeutic strategies. One promising target is estrogen receptor β (ERβ), which promotes the expression of key tight junction proteins, sealing the BBB and reducing its permeability. In this study, we investigated the effects of 17β-estradiol (E2) and the selective ERβ agonist diarylpropionitrile (DPN) on endothelial and cancer cells...
March 16, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38539641/clivus-cervical-stabilization-through-transoral-approach-in-patients-with-craniocervical-tumor-three-cases-and-surgical-technical-note
#3
JOURNAL ARTICLE
Gervith Reyes-Soto, Alfonso Corona De la Torre, Kaori Guadalupe Honda Partida, Renat Nurmukhametov, Manuel De Jesus Encarnacion Ramirez, Nicola Montemurro
Craniocervical tumors lead to cervical pain, instability, and neurological symptoms, reducing the quality of life. Effective surgical intervention at the craniocervical junction (CCJ) is critical and complex, involving comprehensive approaches and advanced reconstructive techniques. This study, conducted at Mexico City's National Institute of Cancerology, focused on three surgical cases that occurred in 2023 involving tumors at the CCJ: two chordomas and one prostate adenocarcinoma. We utilized a specialized technique: clivus-cervical stabilization reinforced with a polymethylmethacrylate (PMMA)-filled cervical mesh...
March 5, 2024: Brain Sciences
https://read.qxmd.com/read/38539550/contrast-clearance-analysis-cca-to-assess-viable-tumour-following-stereotactic-radiosurgery-srs-to-brain-metastasis-in-non-small-cell-lung-cancer-nsclc
#4
JOURNAL ARTICLE
Shybi Mohamedkhan, Sumeet Hindocha, James de Boisanger, Thomas Millard, Liam Welsh, Philip Rich, Andrew D MacKinnon, Nicholas Williams, Bhupinder Sharma, Nicola Rosenfelder, Anna Minchom
BACKGROUND AND OBJECTIVE: Brain metastases are common in lung cancer and increasingly treated using targeted radiotherapy techniques such as stereotactic radiosurgery (SRS). Using MRI, post-SRS changes may be difficult to distinguish from progressive brain metastasis. Contrast clearance analysis (CCA) uses T1-weighted MRI images to assess the clearance of gadolinium and can be thus used to assess vascularity and active tumours. DESIGN AND METHODS: We retrospectively assessed CCAs in 62 patients with non-small cell lung cancer (NSCLC) undergoing 104 CCA scans in a single centre...
March 20, 2024: Cancers
https://read.qxmd.com/read/38538691/potential-diagnostic-and-drug-target-markers-in-glioblastoma
#5
JOURNAL ARTICLE
Hina Ahsan, Muhammad Asghar, Shaukat Iqbal Malik
Glioblastoma multiforme (GBM) IDH-wildtype is the most prevalent brain malignancy in adults. However, molecular mechanisms, which leads to GBM have not been completely elucidated. Granulocyte colony-stimulating factor (GCSF), Granulocyte colony-stimulating factor receptor GCSFR, and Signal transducers and activators of transcription 3 (STAT3) have been involved in the occurrence and development of various cancers, but their role in GBM is little known. Herein, we have investigated the gene and protein expression of GCSF, GCSFR, and STAT3 in 21 tissue biopsy samples and also in tumor associated normal tissue (TANT) samples derived from glioblastoma patients, which revealed significantly differential expression of these genes...
March 27, 2024: Scientific Reports
https://read.qxmd.com/read/38538274/nop14-as-a-potential-predictor-of-adult-type-diffuse-glioma-prognosis-and-immunotherapy-is-related-to-cell-migration-proliferation-and-cd8-t-cell-infiltration
#6
JOURNAL ARTICLE
Qiu-Si Tian, Jing Cheng, Zhi-Jun Bao
BACKGROUND: World Health Organization (WHO) grade 4 adult-type diffuse glioma is the most malignant primary tumor of the brain. Nucleolar protein 14 ( NOP14 ) is recognized to contribute significantly to the assembly of small ribosomal subunits. However, the specific involvement of NOP14 in diverse cancers remains poorly understood, particularly its role in adult-type diffuse glioma, which has yet to be elucidated. METHODS: A total of 20 adult-type diffuse glioma samples with varying WHO stages were collected...
March 15, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38536543/effect-of-early-dose-reduction-of-osimertinib-on-efficacy-in-the-first-line-treatment-for-egfr-mutated-non-small-cell-lung-cancer
#7
JOURNAL ARTICLE
Tomoki Hori, Kazuhiro Yamamoto, Takefumi Ito, Shigeki Ikushima, Tomohiro Omura, Ikuko Yano
Osimertinib is used as the first-line therapy for patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). However, early dose reduction is often required due to adverse events (AEs). This study aimed to evaluate the effect of early dose reduction of osimertinib on efficacy and safety. This was a retrospective study including patients with EGFR-mutated NSCLC who were started on osimertinib as the first-line therapy between August 2018 and December 2021. Patients whose doses were reduced to less than 80 mg/day within 6 months of osimertinib initiation or started at 40 mg/day were defined as the dose reduction group...
March 27, 2024: Investigational New Drugs
https://read.qxmd.com/read/38534959/outcomes-of-patients-with-non-small-cell-lung-cancer-and-brain-metastases-treated-with-the-upfront-single-agent-pembrolizumab-a-retrospective-and-multicentric-study-of-the-esckeyp-gfpc-cohort
#8
MULTICENTER STUDY
Simon Nannini, Florian Guisier, Hubert Curcio, Charles Ricordel, Pierre Demontrond, Safa Abdallahoui, Seyyid Baloglu, Laurent Greillier, Christos Chouaid, Roland Schott
Non-small cell lung cancer (NSCLC) is the most common cause of brain metastasis (BM). Little is known about immune checkpoint inhibitor activity in the central nervous system, especially in patients receiving monotherapy for tumors with a tumor proportion score (TPS) ≥ 50%. This noninterventional, retrospective, multicenter study, conducted with the GFPC, included treatment-naïve patients strongly positive for PD-L1 (TPS ≥ 50%) with BM receiving first-line single-agent pembrolizumab treatment between May 2017 and November 2019...
March 21, 2024: Current Oncology
https://read.qxmd.com/read/38533085/membrane-trafficking-alterations-in-breast-cancer-progression
#9
REVIEW
Andreia Ferreira, Pedro Castanheira, Cristina Escrevente, Duarte C Barral, Teresa Barona
Breast cancer (BC) is the most common type of cancer in women, and remains one of the major causes of death in women worldwide. It is now well established that alterations in membrane trafficking are implicated in BC progression. Indeed, membrane trafficking pathways regulate BC cell proliferation, migration, invasion, and metastasis. The 22 members of the ADP-ribosylation factor (ARF) and the >60 members of the rat sarcoma (RAS)-related in brain (RAB) families of small GTP-binding proteins (GTPases), which belong to the RAS superfamily, are master regulators of membrane trafficking pathways...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38532756/metastatic-progression-of-breast-cancer-along-with-decreased-mitochondrial-cell-death-priming-of-breast-cancer-cells-a-case-report
#10
Yeliz Aka, Hulya Ozdemir, Nese Torun, Filiz Aka Bolat, Ozgur Kutuk
Metastatic breast cancer remains to be a major cause of cancer-related deaths in women. Exploring the molecular mechanisms to identify targetable alterations in progressing breast cancer and developing functional tools to predict therapy response in these patients are needed. In this report, we present a case of breast cancer patient who progressed following surgery and adjuvant endocrine therapy. Radiological and pathological analyses revealed metastasis to liver and brain. Paired liquid biopsies demonstrated acquired ERBB2 mutations in addition to TP53 and PIK3CA mutations, which were also present before progression...
March 2024: Oxford Medical Case Reports
https://read.qxmd.com/read/38532729/serplulimab-monotherapy-in-extensive-stage%C3%A2-small-cell-lung-cancer-with-brain-metastasis-a-case-report
#11
JOURNAL ARTICLE
Xudong Xiang, Heng Li, Bao Lei, Benchao Chen, Gaofeng Li
Small-cell lung cancer (SCLC) is an aggressive form of lung cancer with limited treatment options, especially for extensive-stage (ES) patients. We present a case of a 70-year-old male with ES-SCLC and asymptomatic brain metastasis who opted for immune monotherapy with serplulimab (an anti-PD-1 antibody). After four cycles, the patient achieved a confirmed partial response and a progression-free survival of over 1 year. Moreover, we observed a consistent decline in tumor biomarkers, and brain MRI indicated reduced metastatic activity...
March 27, 2024: Immunotherapy
https://read.qxmd.com/read/38530549/a-systematic-review-of-extraneural-meningioma-metastasis-timing-evolution-and-outlook
#12
REVIEW
Gina Watanabe, Kurtis Young, Erin Rauber, Mohammad Faizan Khan, Reannon Suzuki, Robert Riestenberg, Giuseppe E Umana, Paolo Palmisciano
PURPOSE: Extraneural meningioma metastasis is a rare occurrence and may pose a clinical challenge due to its unclear prognosis. In this systematic review, we analyze patient demographics, clinical characteristics, management strategies, and outcomes. METHODS: PubMed, EMBASE, Scopus, Cochrane, and Web of Science databases were searched from inception to February 23, 2024 for cases of metastatic meningioma according to PRISMA guidelines. Descriptive statistics, Mann-Whitney U test, Fisher's exact tests, Kaplan-Meier curves, and log-rank tests were used for selected analyses...
March 26, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38530545/glioblastoma-stem-cell-metabolism-and-immunity
#13
REVIEW
Joseph Hawly, Micaela G Murcar, Alejandro Schcolnik-Cabrera, Mark E Issa
Despite enormous efforts being invested in the development of novel therapies for brain malignancies, there remains a dire need for effective treatments, particularly for pediatric glioblastomas. Their poor prognosis has been attributed to the fact that conventional therapies target tumoral cells, but not glioblastoma stem cells (GSCs). GSCs are characterized by self-renewal, tumorigenicity, poor differentiation, and resistance to therapy. These characteristics represent the fundamental tools needed to recapitulate the tumor and result in a relapse...
March 26, 2024: Cancer Metastasis Reviews
https://read.qxmd.com/read/38529509/overcoming-brain-derived-therapeutic-resistance-in-her2-breast-cancer-brain-metastasis
#14
Danyyl Ippolitov, Yi-Han Lin, Jeremy Spence, Aleksandra Glogowska, Thatchawan Thanasupawat, Jason Beiko, Marc R Del Bigio, Xin Xu, Amy Wang, Raul Calvo, Abhijeet Kapoor, Juan J Marugan, Mark J Henderson, Thomas Klonisch, Sabine Hombach-Klonisch
Brain metastasis of HER2+ breast cancer occurs in about 50% of all women with metastatic HER2+ breast cancer and confers poor prognosis for patients. Despite effective HER2-targeted treatments of peripheral HER2+ breast cancer with Trastuzumab +/-HER2 inhibitors, limited brain permeability renders these treatments inefficient for HER2+ breast cancer brain metastasis (BCBM). The scarcity of suitable patient-derived in-vivo models for HER2+ BCBM has compromised the study of molecular mechanisms that promote growth and therapeutic resistance in brain metastasis...
February 22, 2024: bioRxiv
https://read.qxmd.com/read/38527263/local-and-systemic-management-options-for-melanoma-brain-metastases
#15
REVIEW
Afsaneh Amouzegar, Hussein A Tawbi
Development of brain metastasis is one of the most serious complications of advanced melanoma, carrying a significant burden of morbidity and mortality. Although advances in local treatment modalities such as stereotactic radiosurgery and breakthrough systemic therapies including immunotherapy and targeted therapies have improved the outcomes of patients with metastatic melanoma, management of patients with melanoma brain metastases (MBMs) remains challenging. Notably, patients with MBMs have historically been excluded from clinical trials, limiting insights into their specific treatment responses...
March 2024: Cancer Journal
https://read.qxmd.com/read/38525512/prognostic-factors-and-real-life-applicability-of-prognostic-models-for-patients-with-bone-metastases-of-carcinoma
#16
JOURNAL ARTICLE
Kaan Ali Dalkir, Akif Mirioglu, Bugra Kundakci, Melih Bagir, Mehmet Ali Deveci, Hilmi Serdar Ozberlas
OBJECTIVE: This study aimed to investigate the factors affecting the survival of patients with bone carcinoma metastases and assess the clinical applicability of existing prognostic models. METHODS: We retrospectively evaluated 247 patients who presented to our hospital between 2011 and 2021 diagnosed with bone carcinoma metastasis. Demographic data, general health status, primary diagnoses, laboratory and radiological findings, pathological fracture status, treatment methods, and survival times of the patients were recorded, and the effects of these variables on survival time were evaluated...
January 2024: Acta Orthopaedica et Traumatologica Turcica
https://read.qxmd.com/read/38524679/surgical-resection-of-brain-and-adrenal-gland-metastases-from-gastric-cancer-a-case-report-and-literature-review
#17
Yuto Kitano, Shigekazu Ohyama, Yasumichi Yagi, Ichiro Onishi, Masato Kayahara
The prognosis of recurrent gastric cancer is generally poor, and aggressive surgical treatment is rarely performed. Herein, we present the case of a patient who underwent resection of cerebellar and adrenal gland metastases from gastric cancer. The patient was treated for gastric cancer with distal gastrectomy at 23 years and for remnant gastric cancer with completion gastrectomy at 48 years. At 59 years old, she experienced vertigo and nausea and was diagnosed with cerebellar and left adrenal gland tumours...
March 2024: Journal of Surgical Case Reports
https://read.qxmd.com/read/38524022/clinical-characteristics-and-prognostic-factors-of-endometrial-cancer-patients-with-liver-metastasis-a-surveillance-epidemiology-and-end-results-database-seer-based-study-of-1-034-women
#18
JOURNAL ARTICLE
Abdulhameed Alhadeethi, Ahmed A Ibrahim, Ahmed Atia, Yasmeen J Alabdallat, Ibraheem M Alkhawaldeh, Mostafa H El Din Moawad
Background There are several patterns of metastatic spread from endometrial cancer (EC). Although studies have been conducted to study the EC population with distant metastasis in the bone and lungs, there is still a lack of studies on liver metastasis. This study aims to evaluate and assess the clinical features and prognostic factors of EC patients with liver metastasis. Methodology We conducted a retrospective cohort study adhering to the guidelines for reporting observational research. We utilized the Surveillance, Epidemiology, and End Results database to gather data on female patients diagnosed with EC and reported liver metastasis...
February 2024: Curēus
https://read.qxmd.com/read/38523942/a-rare-case-of-spindle-cell-sarcoma-with-rare-asymptomatic-cerebellar-metastasis
#19
Candace Miyaki, Kathie Wu, David Nye, Nadia Ramdin
Sarcomas are one of the rarest cancers, occurring in less than 1% of all adult malignancies. Spindle cell sarcomas are one subset of soft tissue sarcomas that are even less commonly reported in the literature due to the scarcity of cases, especially with the presence of brain metastases. We present a case of an adult male who presented with non-specific exertional dyspnea and chest pain, which was found to have spindle cell sarcoma with cerebellar metastasis.
February 2024: Curēus
https://read.qxmd.com/read/38523916/unusual-metastatic-patterns-of-wilms-tumor-a-case-series
#20
Lily G Tagoe, Nana Yaa A Bonney, Emmanuella Amoako, Kokou H Amegan-Aho, Hafisatu Gbadamosi, Mary-Ann Dadzie, Catherine I Segbefia
Wilms tumor (WT) is the most common renal malignancy of childhood. The common metastatic sites are the lungs, liver, and lymph nodes, with brain and bone metastases occurring rarely. Metastatic disease can be present at initial diagnosis or may occur with relapse or disease progression. The majority of relapses in WT occur within the first two years post-treatment. Late relapses are rare. This article describes four cases of WT, each demonstrating an unusual site or timing of metastases. Case 1 presented primarily with jaw metastases, Case 2 presented with bone (vertebrae) and spinal metastases manifesting as paraplegia, at relapse one year after completion of treatment, Case 3 presented with isolated liver metastases four years after treatment completion, and Case 4 presented with brain metastases after six weeks of treatment abandonment...
February 2024: Curēus
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