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https://www.readbyqxmd.com/read/28527429/coexistence-of-light-driven-na-and-h-transport-in-a-microbial-rhodopsin-from-nonlabens-dokdonensis
#1
Hongshen Zhao, Baofu Ma, Liangliang Ji, Longjie Li, Huanhuan Wang, Deliang Chen
Ion pumping microbial rhodopsins are photochemically active membrane proteins, converting light energy into ion-motive-force for ATP synthesis. Nonlabens dokdonensis rhodopsin 2 (NdR2), was recently identified as a light-driven Na(+) pump. However, few functional studies on NdR2 have been conducted to elucidate its mechanism of ion transport. By reconstituting NdR2 into liposomes, we proved that NdR2 functions as a light-driven Na(+)/H(+) pump. As Na(+) concentration increased, the dominant H(+) pump activity switched to the Na(+) pump activity at neutral pH...
May 10, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28527428/physicochemical-and-biological-interactions-between-cerium-oxide-nanoparticles-and-a-1-8-naphthalimide-derivative
#2
Gerardo Pulido-Reyes, Esperanza Martín, J L Gu Coronado, Francisco Leganes, Roberto Rosal, Francisca Fernández-Piñas
Cerium (Ce) oxide nanoparticles (CNPs) have attracted attention due to their high bioactivity and unique redox-chemistry. The oxygen vacancies at the surface of the nanoparticle explain the autocatalytic properties of CNPs in which the Ce(3+) atoms occupy the center of the oxygen vacancies surrounded by Ce(4+) atoms. Until now, CNPs have been associated with organic molecules at the synthesis stage to extend their applications or improve their stability. However, there is a lack of information regarding the post-synthesis interaction of CNPs and organic molecules that could enhance or induce new properties...
May 10, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28527427/photothermal-therapy-using-folate-conjugated-gold-nanoparticles-enhances-the-effects-of-6mv-x-ray-on-mouth-epidermal-carcinoma-cells
#3
Ali Neshastehriz, Mousa Tabei, Shayan Maleki, Samira Eynali, Ali Shakeri-Zadeh
The aim of this study was to develop an optimized method for preparation of folate conjugated gold nanoparticles (F-AuNPs) and to investigate its cytotoxic effects and cell apoptosis in combination with photothermal therapy (PTT) and radiotherapy (RT) for the treatment of mouth epidermal carcinoma cells KB. For this purpose, cells were treated with synthesized F-AuNPs at different concentrations for 6h and then irradiated them with laser beam (532nm, 0.5W/cm(2), 15min). After photothermal therapy, the cells were exposed to 6MV X-ray with a single dose of 2Gy...
May 12, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28527426/malvidin-and-cyanidin-derivatives-from-a%C3%A3-ai-fruit-euterpe-oleracea-mart-counteract-uv-a-induced-oxidative-stress-in-immortalized-fibroblasts
#4
Ganna Petruk, Anna Illiano, Rita Del Giudice, Assunta Raiola, Angela Amoresano, Maria Manuela Rigano, Renata Piccoli, Daria Maria Monti
UV-A radiations are known to induce cellular oxidative stress, leading to premature skin aging. Consumption of açai fruit (Euterpe oleracea Martius) is known to have many health benefits due to its high level of antioxidants. Herein, we analyzed the ability of phenolic compounds extracted from this fruit to attenuate UV-A-induced oxidative stress in immortalized fibroblast. A methanol/water açai extract was fractionated by HPLC and each fraction tested for anti-oxidant stress activity. Immortalized fibroblasts were pre-incubated with açai fractions and then exposed to UV-A radiations...
May 12, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28527424/influence-of-chronic-stretching-on-muscle-performance-systematic-review
#5
D M Medeiros, C S Lima
The aim of the current study was to investigate the influence of chronic stretching on muscle performance (MP) by a systematic review. The search strategy included MEDLINE, PEDro, Cochrane CENTRAL, LILACS, and manual search from inception to June 2016. Randomized and controlled clinical trials, non-randomized, and single group studies that have analyzed the influence of flexibility training (FT) (using any stretching technique) on MP were included. Differently, studies with special populations (children, elderly, and people with any dysfunction/disease), and articles that have used FT protocols shorter than three weeks or 12 sessions were excluded...
May 17, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28527423/task-related-and-person-related-variables-influence-the-effect-of-low-back-pain-on-anticipatory-postural-adjustments
#6
Jesse V Jacobs, Courtney A Lyman, Juvena R Hitt, Sharon M Henry
BACKGROUND: People with low back pain exhibit altered postural coordination that has been suggested as a target for treatment, but heterogeneous presentation has rendered it difficult to identify appropriate candidates and protocols for such treatments. This study evaluated the associations of task-related and person-related factors with the effect of low back pain on anticipatory postural adjustments. METHODS: Thirteen subjects with and 13 without low back pain performed seated, rapid arm flexion in self-initiated and cued conditions...
May 17, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28527422/index-of-difficulty-and-side-of-space-are-accommodated-during-the-selection-and-planning-of-a-joint-action
#7
Matthew Ray, John de Grosbois, Timothy N Welsh
Co-actors can facilitate the achievement of a shared goal by accurately anticipating each other's needs and subsequently planning actions to accommodate those needs. The purpose of the present study was to determine if co-actors plan and execute their movements to accommodate the difficulty of their partners' action. We hypothesized that information derived from shared task representations could influence the simulation of other's actions and that motor experience would enhance the ability of co-actor's to anticipate their co-actor's needs...
May 17, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28527421/a-phase-iii-randomized-multi-center-double-blind-placebo-controlled-study-of-safety-and-efficacy-of-lofexidine-for-relief-of-symptoms-in-individuals-undergoing-inpatient-opioid-withdrawal
#8
Charles W Gorodetzky, Sharon L Walsh, Peter R Martin, Andrew J Saxon, Kristen L Gullo, Kousick Biswas
BACKGROUND: Lofexidine is an alpha-2-adrenergic receptor agonist approved in the United Kingdom (UK) for the treatment of opioid withdrawal symptoms. Lofexidine has demonstrated better efficacy than placebo for reducing opioid withdrawal symptoms in patients undergoing opioid withdrawal with less reported hypotension than clonidine. METHODS: Designed as an FDA registration trial, this 8-day, randomized, double-blind, placebo-controlled, parallel-group study in 264 patients dependent on short-acting opioids evaluated the efficacy of lofexidine hydrochloride in reducing withdrawal symptoms in patients undergoing opioid withdrawal...
May 10, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28527420/factors-predictive-of-locoregional-recurrence-following-neoadjuvant-chemotherapy-in-patients-with-large-operable-or-locally-advanced-breast-cancer-an-analysis-of-the-eortc-10994-big-1-00-study
#9
Pauline Gillon, Nathan Touati, Christel Breton-Callu, Leen Slaets, David Cameron, Hervé Bonnefoi
PURPOSE: Identification of clinicopathological factors predicting for a locoregional recurrence (LRR) after neoadjuvant chemotherapy (NAC) could help to decide on the optimal locoregional radiotherapy. The objective of this trial is to identify those factors in the context of a phase III trial (European Organisation for Research and Treatment of Cancer 10994). METHODS: Patients received NAC followed by surgery with or without radiotherapy. Radiotherapy was administered according to pre-specified guidelines...
May 17, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28527419/ring-opening-polymerization-of-new-3-o-branched-1-6-anhydro-glucopyranose-di-and-trisaccharide-monomers
#10
Chaolumen Bai, Davaanyam Budragchaa, Takashi Yoshida
New 3-O-branched 1, 6-anhydro glucopyranose disaccharide monomers, 1, 6-anhydro-2, 4-di-O- benzyl-3-O-(2', 3', 4', 6'-tetra-O-benzyl-α-D-mannopyranosyl)- (LGM 6) and -glucopyranosyl)-β-D- glucopyranose (LGG 7), and a trisaccharide monomer, 1, 6-anhydro-2, 4-di-O-benzyl-3-O-α-(2', 3', 6', 2″, 3″, 4″, 6″-hepta-O-benzyl- α-D-maltopyranosyl)-β-D-glucopyranose (LGMAL 8), were synthesized and polymerized. It was found that the 3-O-branched1, 6-anhydro disaccharide monomers were polymerized. However, the polymerizability was lower than that of the 4-O-branched disaccharide monomers reported previously, and the trisaccharide monomer was not polymerizable, probably due to the steric hindrance of the branched bulky mono and disaccharide units at the 3-O position in 1, 6-anhydro glucopyranose...
April 22, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28527418/atmospheric-pcdd-f-concentration-and-source-apportionment-in-typical-rural-agent-orange-hotspots-and-industrial-areas-in-vietnam
#11
Tuan Hung Ngo, To Thi Hien, Ngo Thi Thuan, Nguyen Hung Minh, Kai Hsien Chi
Vietnam has a double burden of dioxin from both industrial sources and historical sources. To evaluate the concentration of PCDD/Fs in ambient air in different areas of Vietnam and their possible sources, atmospheric samples were collected from three areas namely Son La (rural area) and Da Nang (harbor - Agent Orange hotspot area), and Ho Chi Minh City (metropolitan - industrial city). Vapor and solid phases of PCDD/Fs were collected and analyzed following the TO-9A sampling method. Principal Component Analysis and Positive Matrix Factorization model were applied to characterize the possible source...
May 11, 2017: Chemosphere
https://www.readbyqxmd.com/read/28527417/fate-of-the-sunscreen-compound-oxybenzone-in-cyperus-alternifolius-based-hydroponic-culture-uptake-biotransformation-and-phytotoxicity
#12
Feiran Chen, Christian Huber, Peter Schröder
Oxybenzone (OBZ), a common ingredient in sunscreens and personal care products, has been frequently detected in effluents from municipal wastewater treatment plants and also in surface waters. OBZ is an emerging contaminant due to its adverse impacts on marine/aquatic ecosystems. To investigate the removal and degradation capacity of phytotreatment for OBZ, the common wetland plant species Cyperus alternifolius L. was exposed to this compound at 5, 25 and 50 μM for 120 h, respectively. Continuous uptake by roots and accumulation in plant tissues was observed over the exposure time, and depletion of spiked OBZ from the aqueous medium exceeded 73...
May 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28527416/ochratoxin-a-induces-nephrotoxicity-and-immunotoxicity-through-different-mapk-signaling-pathways-in-pk15-cells-and-porcine-primary-splenocytes
#13
Fang Gan, Yaojiao Zhou, Lili Hou, Gang Qian, Xingxiang Chen, Kehe Huang
Ochratoxin A (OTA) is reported to be a potent nephrotoxin and immunotoxin in animals and humans. However, the mechanisms underlying OTA toxicity have not been clearly determined until now. Toxicity of OTA and its mechanism was investigated in PK15 cells and in porcine primary splenocytes. The results showed that OTA at 2.0-8.0 μg/mL for 24 h induced cytotoxicity and apoptosis in a dose-dependent manner in PK 15 cells. OTA at 0.5-4.0 μg/mL for 24 h induced cytotoxicity and apoptosis in a dose-dependent manner in porcine primary splenocytes...
May 9, 2017: Chemosphere
https://www.readbyqxmd.com/read/28527415/trace-bromide-ion-impurity-leads-to-formation-of-chlorobromoaromatic-by-products-in-peroxymonosulfate-based-oxidation-of-chlorophenols
#14
Changling Fang, Zhaohui Wang, Min Feng, Ying Huang, Fei Yang, Jianshe Liu
Trace bromide (Br(-)) released from industrial effluents or brominated compounds is able to directly react with peroxymonosulfate (PMS) to generate a series of reactive oxidants which can oxidize and also halogenate organics. We report the identification and evolution of by-products during 2,4,6-trichlorophenol (TCP) degradation in the presence of PMS and trace Br(-). The influencing factors, including Br(-) concentration and pH, were investigated. The depletion of TCP was accelerated with increasing trace Br(-) concentration (0-0...
May 15, 2017: Chemosphere
https://www.readbyqxmd.com/read/28527413/monochromatic-green-light-induces-an-aberrant-accumulation-of-geranylgeranyled-chlorophylls-in-plants
#15
Zuzana Materová, Roman Sobotka, Barbora Zdvihalová, Michal Oravec, Jakub Nezval, Václav Karlický, Daniel Vrábl, Michal Štroch, Vladimír Špunda
Light quality is an important environmental factor affecting the biosynthesis of photosynthetic pigments whose production seems to be affected not only quantitatively but also qualitatively. In this work, we set out to identify unusual pigment detected in leaves of barley (Hordeum vulgare L.) and explain its presence in plants grown under monochromatic green light (GL; 500-590 nm). The chromatographic analysis (HPLC-DAD) revealed that a peak belonging to this unknown pigment is eluted between chlorophyll (Chl) a and b...
May 6, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28527412/early-stage-detection-of-ve-cadherin-during-endothelial-differentiation-of-human-mesenchymal-stem-cells-using-spr-biosensor
#16
Farzaneh Fathi, Aysa Rezabakhsh, Reza Rahbarghazi, Mohammad-Reza Rashidi
Surface plasmon resonance (SPR) biosensors are most commonly applied for real-time dynamic analysis and measurement of interactions in bio-molecular studies and cell-surface analysis without the need for labeling processes. Up to present, SPR application in stem cell biology and biomedical sciences was underused. Herein, a very simple and sensitive method was developed to evaluate human mesenchymal stem cells trans-differentiation to endothelial lineage of over a period of 14 days based on VE-cadherin biomarker...
May 10, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28527411/trends-in-reports-of-driving-following-illicit-drug-consumption-among-regular-drug-users-in-australia-2007-2013-has-random-roadside-drug-testing-had-a-deterrent-effect
#17
Danielle Horyniak, Paul Dietze, Simon Lenton, Rosa Alati, Raimondo Bruno, Allison Matthews, Courtney Breen, Lucy Burns
INTRODUCTION: Driving following illicit drug consumption ('drug-driving') is a potential road safety risk. Roadside drug testing (RDT) is conducted across Australia with the dual aims of prosecuting drivers with drugs in their system and deterring drug-driving. We examined trends over time in self-reported past six-month drug-driving among sentinel samples of regular drug users and assessed the impact of experiences of RDT on drug-driving among these participants. METHODS: Data from 1913 people who inject drugs (PWID) and 3140 regular psychostimulant users (RPU) who were first-time participants in a series of repeat cross-sectional sentinel studies conducted in Australian capital cities from 2007 to 2013 and reported driving in the past six months were analysed...
May 17, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28527409/molecular-characterization-of-pigeon-torque-teno-virus-pttv-in-jiangsu-province
#18
Zhicheng Zhang, Wei Dai, Dingzhen Dai
The torque teno virus (TTV) is a recently discovered DNA virus that has been detected in many different hosts, including humans, livestock and poultry. To date, there is no report of pigeon TTV (PTTV) from anywhere in the world. To investigate the distribution of PTTV in pigeons from the eastern Chinese province of Jiangsu and characterize their genomes, we employed PCR to detect PTTV in 144 samples collected from 6 pigeon plants in Jiangsu province, amplify complete genomes from representative samples and analyze genetic characteristics using bioinformatics...
May 6, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28527408/subcellular-localization-based-comparative-study-on-radioresistant-bacteria-a-novel-approach-to-mine-proteins-involve-in-radioresistance
#19
Divya Vishambra, Malay Srivastava, Kamal Dev, Varun Jaiswal
Radioresistant bacteria (RRB) are among the most radioresistant organisms and has a unique role in evolution. Along with the evolutionary role, radioresistant organisms play important role in paper industries, bioremediation, vaccine development and possibility in anti-aging and anti-cancer treatment. The study of radiation resistance in RRB was mainly focused on cytosolic mechanisms such as DNA repair mechanism, cell cleansing activity and high antioxidant activity. Although it was known that protein localized on outer areas of cell play role in resistance towards extreme condition but the mechanisms/proteins localized on the outer area of cells are not studied for radioresistance...
May 10, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28527407/mechanisms-of-resistance-to-systemic-therapy-in-metastatic-castration-resistant-prostate-cancer
#20
REVIEW
Giuseppe Galletti, Benjamin I Leach, Linda Lam, Scott T Tagawa
Patients with metastatic castration-resistant prostate cancer (mCPRC) now have an unprecedented number of approved treatment options, including chemotherapies (docetaxel, cabazitaxel), androgen receptor (AR)-targeted therapies (enzalutamide, abiraterone), a radioisotope (radium-223) and a cancer vaccine (sipuleucel-T). However, the optimal treatment sequencing pathway is unknown, and this problem is exacerbated by the issues of primary and acquired resistance. This review focuses on mechanisms of resistance to AR-targeted therapies and taxane-based chemotherapy...
May 8, 2017: Cancer Treatment Reviews
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