keyword
https://read.qxmd.com/read/38527764/inhibition-of-jak-stat-pathway-corrects-salivary-gland-inflammation-and-interferon-driven-immune-activation-in-sj%C3%A3-gren-s-disease
#21
JOURNAL ARTICLE
Sarthak Gupta, Eiko Yamada, Hiroyuki Nakamura, Paola Perez, Thomas Jf Pranzatelli, Kalie Dominick, Shyh-Ing Jang, Mehdi Abed, Daniel Martin, Peter Burbelo, ChangYu Zheng, Ben French, Ilias Alevizos, Zohreh Khavandgar, Margaret Beach, Eileen Pelayo, Brian Walitt, Sarfaraz Hasni, Mariana J Kaplan, Mayank Tandon, Maria Teresa Magone, David E Kleiner, John A Chiorini, Alan Baer, Blake M Warner
OBJECTIVES: Inflammatory cytokines that signal through the Janus kinases-signal transducer and activator of transcription (JAK-STAT) pathway, especially interferons (IFNs), are implicated in Sjögren's disease (SjD). Although inhibition of JAKs is effective in other autoimmune diseases, a systematic investigation of IFN-JAK-STAT signalling and the effect of JAK inhibitor (JAKi) therapy in SjD-affected human tissues has not been fully investigated. METHODS: Human minor salivary glands (MSGs) and peripheral blood mononuclear cells (PBMCs) were investigated using bulk or single-cell (sc) RNA sequencing (RNAseq), immunofluorescence (IF) microscopy and flow cytometry...
March 25, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38527692/hexavalent-chromium-exposure-activates-the-non-canonical-nuclear-factor-kappa-b-pathway-to-promote-immune-checkpoint-protein-programmed-death-ligand-1-expression-and-lung-carcinogenesis
#22
JOURNAL ARTICLE
Po-Shun Wang, Zulong Liu, Osama Sweef, Abdullah Farhan Saeed, Thomas Kluz, Max Costa, Kenneth R Shroyer, Kazuya Kondo, Zhishan Wang, Chengfeng Yang
Lung cancer is the leading cause of cancer-related death worldwide; however, the mechanism of lung carcinogenesis has not been clearly defined. Chronic exposure to hexavalent chromium [Cr(VI)], a common environmental and occupational pollutant, causes lung cancer, representing an important lung cancer etiology factor. The mechanism of how chronic Cr(VI) exposure causes lung cancer remains largely unknown. By using cell culture and mouse models and bioinformatics analyses of human lung cancer gene expression profiles, this study investigated the mechanism of Cr(VI)-induced lung carcinogenesis...
March 23, 2024: Cancer Letters
https://read.qxmd.com/read/38526286/ruxolitinib-improves-the-inflammatory-microenvironment-restores-glutamate-homeostasis-and-promotes-functional-recovery-after-spinal-cord-injury
#23
JOURNAL ARTICLE
Jiang Cao, Xiao Yu, Jingcheng Liu, Jiaju Fu, Binyu Wang, Chaoqin Wu, Sheng Zhang, Hongtao Chen, Zi Wang, Yinyang Xu, Tao Sui, Jie Chang, Xiaojian Cao
JOURNAL/nrgr/04.03/01300535-202419110-00030/figure1/v/2024-03-08T184507Z/r/image-tiff The inflammatory microenvironment and neurotoxicity can hinder neuronal regeneration and functional recovery after spinal cord injury. Ruxolitinib, a JAK-STAT inhibitor, exhibits effectiveness in autoimmune diseases, arthritis, and managing inflammatory cytokine storms. Although studies have shown the neuroprotective potential of ruxolitinib in neurological trauma, the exact mechanism by which it enhances functional recovery after spinal cord injury, particularly its effect on astrocytes, remains unclear...
November 1, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38526174/antibody-targeting-tslp-suppresses-dss-induced-colitis-and-activation-of-the-jak2-stat5-pathway-in-mice
#24
JOURNAL ARTICLE
Wei Zhuang, Zhen Li
There is currently no safe or effective treatment for inflammatory bowel disease (IBD), which is defined as recurrent and persistent intestinal inflammation. Thymic stromal lymphopoietin (TSLP) has been shown to be associated with the pathogenesis of IBD, and the JAK2/STAT5 signalling pathway has demonstrated much promise as a novel therapeutic target for IBD. In this study, we first evaluated levels of TSLP in dextran sodium sulphate (DSS)-induced IBD mice. Second, we applied tezepelumab, an anti-TSLP monoclonal antibody (20 μg per mouse, intraperitoneally), to DSS-induced IBD mice and quantified the signs of histopathological change, intestinal inflammation, and integrity of the mucosal barrier...
December 1, 2023: European Cytokine Network
https://read.qxmd.com/read/38525955/jak-inhibitors-for-treating-steroid-dependent-iga-vasculitis
#25
JOURNAL ARTICLE
Qingmiao Sun, Juan Bai, Su Wang, Hong Fang, Jianjun Qiao
No abstract text is available yet for this article.
March 20, 2024: American Journal of Therapeutics
https://read.qxmd.com/read/38525693/indolent-t-cell-lymphoproliferation-of-the-gastrointestinal-tract-an-evolving-disease-entity
#26
Luke Wang, Elaine Koh, Beena Kumar, Michael S Y Low
Background: Indolent T cell lymphoproliferation of the gastrointestinal tract is a novel entity recently added to the 2016 WHO classification of lymphoid neoplasms. Classically, these patients demonstrate an immunophenotype consistent with T cell proliferation and can be either CD4-positive or CD8-positive but with a low Ki67 index, highlighting the indolent nature of this disease compared to its more aggressive T cell lymphoma counterparts such as enteropathy-associated T cell lymphoma and monomorphic epitheliotropic intestinal T cell lymphoma...
March 22, 2024: Hematology Reports
https://read.qxmd.com/read/38525134/protective-effect-of-cilostazol-on-vascular-injury-in-rats-with-acute-ischemic-stroke-complicated-with-chronic-renal-failure
#27
JOURNAL ARTICLE
Ru Sun, Qun Gu, Xufeng Zhang, Ruiqi Zeng, Dan Chen, Jingjing Yao, Jingjing Min
UNLABELLED: Chronic renal failure (CRF) resulting in vascular calcification, which does damage to blood vessels and endothelium, is an independent risk factor for stroke. It has been reported that cilostazol has a protective effect on the focal cerebral ischemic infarct. However, its impact on vascular injury in CRF combined stroke and its molecular protection mechanism have not been investigated. In this study, we carried out the effect of cilostazol on CRF combined stroke rats, and the results confirmed that it improved the neurobehavior, renal function as well as pathologic changes in both the kidney and brain...
April 2024: Toxicological Research
https://read.qxmd.com/read/38524393/a-case-of-vitiligo-combined-with-systemic-lupus-erythematosus-treated-with-tofacitinib
#28
Qingxia Lin, Jinrong Zhu, Xuelei Gao
Vitiligo is a skin depigmentation disease resulting from melanocyte destruction and often co-occurring with autoimmune disorders like hyperthyroidism, alopecia areata, pernicious anemia, and systemic lupus erythematosus (SLE). Although various traditional treatments exist for vitiligo, their effectiveness varies considerably. This report presents a unique case of a vitiligo patient with concomitant systemic lupus erythematosus. Remarkably, after a 30-day course of treatment with tofacitinib, complete repigmentation of the white macular rash was achieved, and there were no adverse drug reactions...
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38522937/-not-available
#29
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
2024: Arerugī, [Allergy]
https://read.qxmd.com/read/38522714/cloning-and-expression-analysis-of-janus-activated-kinase-family-genes-from-spotted-seabass-lateolabrax-maculatus
#30
JOURNAL ARTICLE
Ke Fan, Qian Gao, Chuanguo Cai, Yushuai Xie, Zhitao Qi, Zhaosheng Sun, Jiasong Xie, Jiaqi Gao
Janus kinases (JAKs) are important components of the JAK-STAT signaling pathway and play vital roles in innate immunity, autoimmune diseases, and inflammation. However, information about JAKs remains largely unknown in the spotted seabass, a fish species of Perciformes with great commercial value in the aquaculture industry. The aims of this study are to obtain the complete cDNA sequences of JAKs (JAK1, JAK2A, JAK2B, JAK3 and TYK2) from spotted seabass and to investigate their roles upon stimulation with lipopolysaccharides (LPS) and Edwardsiella tarda, using RT-PCR, PCR and qRT-PCR methods...
March 22, 2024: Developmental and Comparative Immunology
https://read.qxmd.com/read/38521706/targeted-therapy-for-immune-mediated-skin-diseases-what-should-a-dermatologist-know
#31
REVIEW
Edinson López, Raúl Cabrera, Cristóbal Lecaros
BACKGROUND: Molecularly targeted therapies, such as monoclonal antibodies (mAbs) and Janus Kinase inhibitors (JAKis), have emerged as essential tools in the treatment of dermatological diseases. These therapies modulate the immune system through specific signaling pathways, providing effective alternatives to traditional systemic immunosuppressive agents. This review aims to provide an updated summary of targeted immune therapies for inflammatory skin diseases, considering their pathophysiology, efficacy, dosage, and safety profiles...
March 22, 2024: Anais Brasileiros de Dermatologia
https://read.qxmd.com/read/38520787/deciphering-jak-stat-signaling-pathway-a-multifaceted-approach-to-tumorigenesis-progression-and-therapeutic-interventions
#32
REVIEW
Yihui Wang, Zhe Wang, Shuyu Li, Juntao Ma, Xiaoshuo Dai, Jing Lu
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway, essential for cellular communication, orchestrates a myriad of physiological and pathological processes. Recently, the intricate association between the pathway's dysregulation and the progression of malignant tumors has garnered increasing attention. Nevertheless, there is no systematic summary detailing the anticancer effects of molecules targeting the JAK/STAT pathway in the context of tumor progression. This review offers a comprehensive overview of pharmaceutical agents targeting the JAK/STAT pathway, encompassing phytochemicals, synthetic drugs, and biomolecules...
March 22, 2024: International Immunopharmacology
https://read.qxmd.com/read/38520011/clinicopathological-and-molecular-genetic-alterations-in-monomorphic-epitheliotropic-intestinal-t-cell-lymphoma-of-the-small-intestine
#33
JOURNAL ARTICLE
Bing Zhou, Min Guo, Xiaohua Li, Ting Duan, Lizi Peng, Hua Hao
BACKGROUND: Small intestinal monomorphic-epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare aggressive T-cell lymphoma originating in the gastrointestinal tract. This study aimed to investigate the clinicopathological features, immunophenotypes, and molecular genetic changes of MEITL. METHODS: The clinicopathological data for three patients with surgically resected MEITL of the small intestine were collected. Next, immunohistochemical labeling, Epstein-Barr virus (EBV) in situ hybridization, assessment of clonal rearrangement of T-cell receptor (TCR) genes, and next-generation sequencing (NGS) were performed...
March 23, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38519816/pharmacokinetic-profile-of-brepocitinib-with-topical-administration-in-atopic-dermatitis-and-psoriasis-populations-strategy-to-inform-clinical-trial-design-in-adult-and-pediatric-populations
#34
JOURNAL ARTICLE
Farzaneh Maleki, Cheng Chang, Vivek S Purohit, Timothy Nicholas
INTRODUCTION: Topical brepocitinib, a tyrosine kinase (TYK)2/Janus kinase (JAK)1 inhibitor, is in development for psoriasis (PsO) and atopic dermatitis (AD). Quantitative analyses of prior clinical trial data were used to inform future clinical trial designs. METHODS: Two phase 2b studies in patients with AD and PsO were used to characterize the amount of topical brepocitinib and the resultant systemic trough concentration (CTrough ) using a linear mixed-effects regression (LMER)...
March 22, 2024: Pharmaceutical Research
https://read.qxmd.com/read/38519710/mechanisms-and-therapeutic-prospect-of-the-jak-stat-signaling-pathway-in-liver-cancer
#35
REVIEW
JunJun Jia, Xuelian Zhou, Qingfei Chu
Liver cancer (LC) poses a significant global health challenge due to its high incidence and poor prognosis. Current systemic treatment options, such as surgery, chemotherapy, radiofrequency ablation, and immunotherapy, have shown limited effectiveness for advanced LC patients. Moreover, owing to the heterogeneous nature of LC, it is crucial to uncover more in-depth pathogenic mechanisms and develop effective treatments to address the limitations of the existing therapeutic modalities. Increasing evidence has revealed the crucial role of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway in the pathogenesis of LC...
March 22, 2024: Molecular and Cellular Biochemistry
https://read.qxmd.com/read/38517042/investigating-the-association-between-the-tissue-expression-of-mirna-101-jak2-stat3-with-tnf-%C3%AE-il-6-il-1%C3%AE-and-il-10-cytokines-in-the-ulcerative-colitis-patients
#36
JOURNAL ARTICLE
Qazaleh Voshagh, Amir Anoshiravani, Amin Karimpour, Golnaz Goodarzi, Sadra Samavarchi Tehrani, Ozra Tabatabaei-Malazy, Ghodratollah Panahi
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease caused by numerous factors, such as immune system dysfunction and genetic factors. MicroRNAs (miRNAs) play a crucial role in UC pathogenesis, particularly via the JAK-STAT pathway. Our aim was to investigate the association between miRNA-101 and JAK2-STAT3 signaling pathway with inflammatory cytokines in UC patients. METHODS: We enrolled 35 UC patients and 35 healthy individuals as the control group, referred to Shariati Hospital, Tehran, Iran...
March 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38516192/revealing-innovative-jak1-and-jak3-inhibitors-a-comprehensive-study-utilizing-qsar-3d-pharmacophore-screening-molecular-docking-molecular-dynamics-and-mm-gbsa-analyses
#37
JOURNAL ARTICLE
Abdelmoujoud Faris, Ivana Cacciatore, Radwan Alnajjar, Hadni Hanine, Adnane Aouidate, Ramzi A Mothana, Abdullah R Alanzi, Menana Elhallaoui
The heterocycle compounds, with their diverse functionalities, are particularly effective in inhibiting Janus kinases (JAKs). Therefore, it is crucial to identify the correlation between their complex structures and biological activities for the development of new drugs for the treatment of rheumatoid arthritis (RA) and cancer. In this study, a diverse set of 28 heterocyclic compounds selective for JAK1 and JAK3 was employed to construct quantitative structure-activity relationship (QSAR) models using multiple linear regression (MLR)...
2024: Frontiers in Molecular Biosciences
https://read.qxmd.com/read/38515287/id-factors-regulate-the-ability-of-m%C3%A3-ller-glia-to-become-proliferating-neurogenic-progenitor-like-cells
#38
JOURNAL ARTICLE
Olivia B Taylor, Snehal P Patel, Evan C Hawthorn, Heithem M El-Hodiri, Andy J Fischer
The purpose of this study was to investigate how ID factors regulate the ability of Müller glia (MG) to reprogram into proliferating MG-derived progenitor cells (MGPCs) in the chick retina. We found that ID1 is transiently expressed by maturing MG (mMG), whereas ID4 is maintained in mMG in embryonic retinas. In mature retinas, ID4 was prominently expressed by resting MG, but following retinal damage ID4 was rapidly upregulated and then downregulated in MGPCs. By contrast, ID1, ID2, and ID3 were low in resting MG and then upregulated in MGPCs...
March 21, 2024: Glia
https://read.qxmd.com/read/38513380/uncovering-the-effect-and-mechanism-of-jiawei-xiaoyao-wan-in-treating-breast-cancer-complicated-with-depression-based-on-network-pharmacology-and-experimental-analysis
#39
JOURNAL ARTICLE
Yongtao Bai, Lianjie Niu, Lihua Song, Guoliang Dai, Wenzhou Zhang, Baoxia He, Wenqing San, Shuolei Li
BACKGROUND: Depression is a clinically common co-morbidity in breast cancer cases that brings negative outcomes on quality of life and potentially survival. Jiawei Xiaoyao Wan (JXW) is widely used in treating breast cancer and depressive disorder, but its potential pharmacological mechanisms remain elusive. PURPOSE: We aimed to explore the dual therapeutic effects and mechanisms of JXW acting on breast cancer complicated with depression (BCCD) by network pharmacology and in vivo experimental verification...
February 7, 2024: Phytomedicine
https://read.qxmd.com/read/38512424/interleukin-3-inhibits-glutamate-cytotoxicity-in-neuroblastoma-cell-line
#40
JOURNAL ARTICLE
Verónica Matus, Marcos Castro-Guarda, Joaquín Cárcamo-Fierro, Francisco J Morera, Angara Zambrano
Interleukin 3 (IL-3) is a well-known pleiotropic cytokine that regulates the proliferation and differentiation of hematopoietic progenitor cells, triggering classical signaling pathways such as JAK/STAT, Ras/MAPK, and PI3K/Akt to carry out its functions. Interestingly, the IL-3 receptor is also expressed in non-hematopoietic cells, playing a crucial role in cell survival. Our previous research demonstrated the expression of the IL-3 receptor in neuron cells and its protective role in neurodegeneration. Glutamate, a principal neurotransmitter in the central nervous system, can induce cellular stress and lead to neurotoxicity when its extracellular concentrations surpass normal levels...
March 21, 2024: Neurochemical Research
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