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https://www.readbyqxmd.com/read/28058078/extramammary-paget-s-disease-of-anal-canal-associated-with-rectal-adenoma-without-invasive-carcinoma
#1
Vaibhav Chumbalkar, Timothy A Jennings, Sanaz Ainechi, Edward C Lee, Hwajeong Lee
Extramammary Paget's disease (EMPD) is a rare disease which is found in apocrine-rich locations such as anogenital region, axilla and rarely in other sites. Perianal EMPD is often reported as the involvement of perianal skin, but involvement of anal mucosa is very rare. Based on pathogenesis and association with either synchronous or metachronous malignancy, EMPD can be divided into primary and secondary types. Treatment approach for these two types of Paget's disease and their prognosis is different, thus it is important to make the distinction...
December 2016: Gastroenterology Research
https://www.readbyqxmd.com/read/28054306/circulating-dickkopf-1-and-sclerostin-in-patients-with-paget-s-disease-of-bone
#2
Luca Idolazzi, Angelo Fassio, Gaia Tripi, Vania Braga, Ombretta Viapiana, Giovanni Adami, Maurizio Rossini, Davide Gatti
Paget disease of bone is a chronic metabolic bone disorder characterized by increased bone resorption and new bone formation. The aim of this study is defining the role of inhibitors of canonical Wnt/b-catenin signaling pathway in patients with Paget disease of bone. Scarce and contrasting results have been reported in literature. We studied 40 patients (15 females and 25 males) with radiological and scintigraphic evidence of Paget disease of bone and 40 healthy subjects matched by age and sex. N-propeptide of type I collagen, C-terminal telopeptide of type I collagen, sclerostin, and Dickkopf-related protein 1 (DKK1) were evaluated by blood samples in our laboratory...
January 5, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28052404/perineal-reconstruction-with-multiple-perforator-flaps-based-on-anatomical-divisions
#3
Joon P Hong, Chang G Kim, Hyun S Suh, Hoon Kim, Chi S Yoon, Kyu N Kim
PURPOSE: Reconstruction of perineal defects remains a challenge because such defects can be extensive, complex, and three-dimensional. This report presents a retrospective review of our past 5 years of experience in perineal reconstruction, and suggests a simple algorithmic approach according to anatomical divisions with multiple pedicled perforator flaps for extensive perineal defects. METHODS: From January 2011 to December 2015, 16 patients, including 5 men and 11 women, underwent reconstruction of extensive perineal defects...
January 4, 2017: Microsurgery
https://www.readbyqxmd.com/read/28051086/neutrophilic-nlrp3-inflammasome-dependent-il-1%C3%AE-secretion-regulates-the-%C3%AE-%C3%AE-t17-cell-response-in-respiratory-bacterial-infections
#4
M Hassane, D Demon, D Soulard, J Fontaine, L E Keller, E C Patin, R Porte, I Prinz, B Ryffel, A Kadioglu, J-W Veening, J-C Sirard, C Faveeuw, M Lamkanfi, F Trottein, C Paget
Traditionally regarded as simple foot soldiers of the innate immune response limited to the eradication of pathogens, neutrophils recently emerged as more complex cells endowed with a set of immunoregulatory functions. Using a model of invasive pneumococcal disease, we highlighted an unexpected key role for neutrophils as accessory cells in innate interleukin (IL)-17A production by lung resident Vγ6Vδ1(+) T cells via nucleotide-binding oligomerization domain receptor, pyrin-containing 3 (NLRP3) inflammasome-dependent IL-1β secretion...
January 4, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28048994/-assessment-of-the-quality-of-life-with-regard-to-health-following-a-cancer-diagnosis
#5
REVIEW
Ikram Es-Saad, Sophie Paget-Bailly, Joëlle Fritzsch, Guillaume Mouillet, Franck Bonnetain
The measurement of the quality of life in terms of health of people undergoing treatment for cancer is developing. This new indicator focusing on patients' personal experience is combined with standard criteria relating to their tumours. The data are also a factor in the prognosis of overall survival. A team of researchers at Besançon university hospital shares its experience.
January 2017: Revue de L'infirmière
https://www.readbyqxmd.com/read/28028810/three-dimensional-evaluation-of-subclinical-extension-of-extramammary-paget-s-disease-visualization-of-histological-border-and-its-comparison-to-clinical-border
#6
T Murata, T Honda, G Egawa, A Kitoh, T Dainichi, A Otsuka, S Nakajima, S Kore-Eda, Y Kaku, S Nakamizo, Y Endo, A Fujisawa, Y Miyachi, K Kabashima
BACKGROUND: In extramammary Paget's disease (EMPD), Paget cells are sometimes detected outside the clinical border (subclinical extension). The spreading pattern of Paget cells in subclinical extension, however, remains unclear. In addition, the macroscopic appearances of lesions accompanied by subclinical extension are totally unknown. OBJECTIVES: To characterize the spreading pattern of Paget cells as well as the macroscopic appearance of lesions of EMPD with subclinical extension...
December 27, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27999157/european-public-health-news
#7
Dineke Zeegers Paget, Natasha Azzopardi-Muscat, Dineke Zeegers Paget, Bernadette N Kumar, Allan Krasnik, Zsuzsana Jakab, Vytenis Andriukaitis, Dineke Zeegers Paget
No abstract text is available yet for this article.
December 2016: European Journal of Public Health
https://www.readbyqxmd.com/read/27994832/mayo-clinic-cancer-center-experience-of-metastatic-extramammary-paget-disease-1998-2012
#8
Leslie Padrnos, Nina Karlin, Thorvardur R Halfdanarson
Extramammary Paget disease (EMPD) is a rare cutaneous malignancy. The most common presentation of EMPD is the vulva followed by perianal involvement. Most cases are localized to the dermis with treatment focused on surgery, topical treatment or radiotherapy. Recurrence is frequent despite therapies utilized. Metastatic extramammary Paget disease is uncommon and, as such, standard treatment guidelines do not exist. This study sought to evaluate the treatment regimens and outcomes of patients treated at a Mayo Clinic Center from 1998-2012...
November 17, 2016: Rare Tumors
https://www.readbyqxmd.com/read/27981818/a-case-of-mandible-paget%C3%A2-s-disease-of-the-bone-treated-with-intravenous-neridronate
#9
A Fassio, L Idolazzi, M Rossini, O Viapiana, D Gatti
Paget's disease of bone (PDB) is a focal disorder of osteoclasts, leading to chaotic bone remodelling, and it is characterized by the presence of focal areas of excessive bone formation alongside with areas of focal bone resorption. The typical radiographic feature is the cotton wool appearance. To date, bisphosphonates are the mainstay of the treatment. We hereby report the case of a young woman presenting with mandible PDB, with a relevant diagnostic delay and mistakenly treated for five years with chronic oral corticosteroids...
December 16, 2016: Reumatismo
https://www.readbyqxmd.com/read/27978609/mammary-pigmented-paget-s-disease-in-a-male-a-diagnostic-challenge
#10
Alessandro Borghi, Monica Corazza, Giulia Toni, Enzo Bianchini, Stefania Zauli, Annarosa Virgili
No abstract text is available yet for this article.
February 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/27976423/mohs-micrographic-surgery-of-rare-cutaneous-tumors
#11
Sophie C Flohil, Charlotte B van Lee, Jessica Beisenherz, Marc A M Mureau, Lucy I H Overbeek, Tamar Nijsten, Renate R van den Bos
BACKGROUND: Recurrence rates after Mohs micrographic surgery (MMS) for rare cutaneous tumors are poorly defined. OBJECTIVE: Investigate the recurrence rate after MMS for rare cutaneous tumors at a university center. METHODS & MATERIALS: Retrospective review of all rare cutaneous tumors treated with MMS at a large university center between January 2008 and December 2012. To detect all recurrences, patients were linked to The nationwide network and registry of histo- and cytopathology (PALGA)...
December 15, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27970833/general-practitioners-perceptions-about-financial-and-non-financial-incentives-to-improve-influenza-vaccination-coverage-rates-in-france
#12
M L Silva, L Perrier, H Späth, J W Paget, V Buthion, A Mosnier, J M Cohen, M Aulois-Griot
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27960049/effect-of-bisphosphonates-on-root-resorption-after-tooth-replantation-a-systematic-review
#13
Shariq Najeeb, Fahad Siddiqui, Zohaib Khurshid, Sana Zohaib, Muhammed Sohail Zafar, Shazia Akbar Ansari
BACKGROUND/AIM: Replantation of avulsed teeth may lead to root resorption. Bisphosphonates (BPs), a class of drugs of used to treat resorptive diseases of the bone such as osteoporosis and Paget's disease, have been observed to exert an anti-resorptive effect on periodontal bone as well. The anti-resorptive properties of BPs could prove them useful in preventing root resorption of replanted avulsed teeth. The aim of this systematic review was to analyze and summarise the currently available literature concerning the use of BPs in preventing root resorption of avulsed teeth...
December 13, 2016: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/27959279/inhibition-of-cancer-cell-mitosis-by-reducing-the-availability-of-phosphate
#14
John Rhys Condon
The addition of phosphate groups is an essential requirement for the proper functioning of cyclin and cyclin dependent kinase which control various stages in the mitotic division of cancer cells. Thus limiting the availability of phosphate is likely to interfere with the metabolism of rapidly growing malignant cells. The human hormone glucagon and the anti metabolite mithramycin reduce serum phosphate by increasing phosphaturia and are both very effective in treating Paget's disease of bone, a precancerous condition...
November 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27938329/erratum-to-development-and-validation-of-the-fragire-tool-for-assessment-an-older-person-s-risk-for-frailty
#15
Dewi Vernerey, Amelie Anota, Pierre Vandel, Sophie Paget-Bailly, Michele Dion, Vanessa Bailly, Marie Bonin, Astrid Pozet, Audrey Foubert, Magdalena Benetkiewicz, Patrick Manckoundia, Franck Bonnetain
No abstract text is available yet for this article.
December 9, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/27935866/hic1-hypermethylated-in-cancer-1-sumoylation-is-dispensable-for-dna-repair-but-is-essential-for-the-apoptotic-dna-damage-response-ddr-to-irreparable-dna-double-strand-breaks-dsbs
#16
Sonia Paget, Marion Dubuissez, Vanessa Dehennaut, Joe Nassour, Brennan T Harmon, Nathalie Spruyt, Ingrid Loison, Corinne Abbadie, Brian R Rood, Dominique Leprince
The tumor suppressor gene HIC1 (Hypermethylated In Cancer 1) encodes a transcriptional repressor mediating the p53-dependent apoptotic response to irreparable DNA double-strand breaks (DSBs) through direct transcriptional repression of SIRT1. HIC1 is also essential for DSB repair as silencing of endogenous HIC1 in BJ-hTERT fibroblasts significantly delays DNA repair in functional Comet assays. HIC1 SUMOylation favours its interaction with MTA1, a component of NuRD complexes. In contrast with irreparable DSBs induced by 16-hours of etoposide treatment, we show that repairable DSBs induced by 1 h etoposide treatment do not increase HIC1 SUMOylation or its interaction with MTA1...
December 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27933004/policy-implications-of-achievement-testing-using-multilevel-models-the-case-of-brazilian-elementary-schools
#17
Igor G Menezes, Victor R Duran, Euclides J Mendonça Filho, Tainã J Veloso, Stella M S Sarmento, Christine L Paget, Kai Ruggeri
Large-scale educational assessment has been established as source of descriptive, evaluative and interpretative information that influence educational policies worldwide throughout the last third of the twentieth century. In the 1990s the Brazilian Ministry of Education developed the National Basic Education Assessment System (SAEB) that regularly measures management, resource and contextual school features and academic achievement in public and private institutions. In 2005, after significant piloting and review of the SAEB, a new sampling strategy was taken and Prova Brasil became the new instrument used by the Ministry to assess skills in Portuguese (reading comprehension) and Mathematics (problem solving), as well as collecting contextual information concerning the school, principal, teacher, and the students...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27932202/environmental-factors-associated-with-familial-or-non-familial-forms-of-paget-s-disease-of-bone
#18
Marie-Claude Audet, Sonia Jean, Claudia Beaudoin, Sabrina Guay-Bélanger, Jeannette Dumont, Jacques P Brown, Laëtitia Michou
OBJECTIVES: The most frequent mutation linked to Paget's disease of bone (PDB), p.Pro392Leu within SQSTM1 gene, leads to phenotypic characteristics of PDB, but this mutation is seemingly insufficient to result in complete pagetic osteoclast phenotype, suggesting that possible environmental factors play a role in PDB pathogenesis. We performed an exploratory study to identify environmental factors potentially associated with familial or non-familial form of PDB in the French-Canadian population...
December 6, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27927711/paget-schroetter-syndrome-imaged-in-multiple-modalities-and-successfully-treated-with-pharmacomechanical-thrombectomy
#19
James William Ryan, Alexandra Murphy, Sarah Wrafter, Vinny Ramiah
No abstract text is available yet for this article.
December 7, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27925382/moving-beyond-not-enough-time-factors-influencing-paediatric-clinicians-participation-in-research
#20
Simon Paul Paget, Patrina Hy Caldwell, Joyce Murphy, Kimberley J Lilischkis, Angie M Morrow
BACKGROUND: Increasing the amount of clinical research that occurs in healthcare settings has been identified as an important mechanism to improve healthcare outcomes. While clinicians are key persons in achieving this aim, research participation amongst clinicians is generally limited. AIMS: To identify the factors (barriers and facilitators) influencing clinician research participation and determine how professional culture impacts on these factors. METHODS: Forty clinicians working at a tertiary children's hospital participated in six discipline-specific focus groups...
December 7, 2016: Internal Medicine Journal
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