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https://www.readbyqxmd.com/read/29151230/intentional-placental-removal-on-suspicious-placenta-accreta-spectrum-still-prohibited
#1
Shigeki Matsubara, Hironori Takahashi
INTRODUCTION: Intentional placental removal for abnormally invasive placenta (AIP) is fundamentally abandoned at planned surgery for it. Whether this holds true even after recent introduction of various hemostatic procedures is unclear. MATERIALS AND METHODS: We discussed on this issue based on our own experiences and also on the recent reports on various hemostatic procedures. RESULTS: Studies directly answering this question have been lacking...
November 18, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29150848/allergen-manufacturing-and-quality-aspects-for-allergen-immunotherapy-in-europe-and-the-united-states-an-analysis-from-the-eaaci-ait-guidelines-project
#2
REVIEW
A Bonertz, G Roberts, J E Slater, J Bridgewater, R L Rabin, M Hoefnagel, M Timon, C Pini, O Pfaar, A Sheikh, D Ryan, C Akdis, J Goldstein, L K Poulsen, R van Ree, C Rhyner, D Barber, O Palomares, R Pawankar, D Hamerlijnk, L Klimek, I Agache, E Angier, T Casale, M Fernandez-Rivas, S Halken, M Jutel, S Lau, G Pajno, G Sturm, E M Varga, R Gerth van Wijk, S Bonini, A Muraro, S Vieths
Adequate quality is essential for any medicinal product to be eligible for marketing. Quality includes verification of the identity, content and purity of a medicinal product in combination with a specified production process and its control. Allergen products derived from natural sources require particular considerations to ensure adequate quality. Here, we describe key aspects of the documentation on manufacturing and quality aspects for allergen immunotherapy products in the European Union and the United States...
November 17, 2017: Allergy
https://www.readbyqxmd.com/read/29149388/problems-of-reconstructive-cranioplasty-after-traumatic-brain-injury-in-children
#3
Paolo Frassanito, Gianpiero Tamburrini, Luca Massimi, Simone Peraio, Massimo Caldarelli, Concezio Di Rocco
Cranial repair after traumatic brain injury in children is still burdened by unsolved problems and controversial issues, mainly due to the high rate of resorption of autologous bone as well as the absence of valid alternative material to replace the autologous bone. Indeed, inert biomaterials are associated to satisfactory results in the short period but bear the continuous risk of complications related to the lack of osteointegration capacity. Biomimetic materials claiming osteoconductive properties that could balance their mechanical limits seem to allow good cranial bone reconstruction...
October 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29149121/ethics-and-genetics-examining-a-crossroads-in-nursing-through-a-case-study%C3%A2
#4
Laura Curr Curr Beamer
BACKGROUND: The field of genetics and genomics is rapidly expanding, particularly in oncology. Genetics and genomics can lead to ethical concerns. Oncology nurses must balance the need for evidence-based oncology care with that of ethical care for patients and their family members. OBJECTIVES: The purpose of this article is to provide an overview of cancer genetics and ethics and their impact on oncology nurses, patients, and families. METHODS: A case study of familial adenomatous polyposis (FAP) is offered to illustrate the impact of a hereditary cancer syndrome on several generations of a family and ethical issues surrounding cancer genetics...
December 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/29148067/should-theophylline-be-added-to-the-j-wave-syndrome-therapeutic-armamentarium
#5
EDITORIAL
Charles Antzelevitch, Sami Viskin
The substrate for both early repolarization syndrome (ERS) and Brugada syndrome (BrS), the so-called J wave syndromes, has been shown to develop as a consequence of genetic variants causing a loss of function of inward currents such sodium (INa ) and calcium (ICa ) channel currents or a gain of function in outward currents such as the transient outward current (Ito ). These changes in ion channel function result in an outward shift of the balance of currents active during the early phases of the epicardial action potential in the right ventricular outflow tract (RVOT) of the heart in the case BrS and in the inferior left ventricle in the case of ERS...
November 16, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29143769/senescent-nephropathy-the-new-renal-syndrome
#6
REVIEW
Florencia Aiello, Eliana P Dueñas, Carlos G Musso
Chronic kidney disease (CKD) is a condition characterized by progressive and irreversible deterioration of renal function due to the reduction of nephron mass for a period of at least three months. The prevalence of CKD is roughly 10% in the general population but increases with age, affecting more than one-third of people older than 65. Frailty is a condition usually found in elderly people, characterized by weakness, motility, and balance issues, with a declined ability to resist stressors leading to increased risks of adverse health outcomes including falls, fracture, hospitalization, institutionalization, disability, dependence, dementia, poor quality of life, and death...
October 28, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29141795/validity-and-reliability-of-the-international-cooperative-ataxia-rating-scale-icars-and-the-scale-for-the-assessment-and-rating-of-ataxia-sara-in-multiple-sclerosis-patients-with-ataxia
#7
Yeliz Salcı, Ayla Fil, Hilal Keklicek, Barış Çetin, Kadriye Armutlu, Anıl Dolgun, Aslı Tuncer, Rana Karabudak
BACKGROUND: Ataxia is an extremely common problem in multiple sclerosis (MS) patients. Thus, appropriate scales are required for detailed assessment of this issue. The aim of our study was to investigate the reliability and validity of the Turkish version of the International Cooperative Ataxia Rating Scale (ICARS) and Scale for the Assessment and Rating of Ataxia (SARA), which are widely used in ataxia evaluation in the context of other cerebellar diseases. METHOD: This cross-sectional study included 80 MS patients with Kurtzke cerebellar functional system score (C-FSS) greater than zero and slight pyramidal involvement...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29141482/obstetric-practice-guidelines-labor-s-love-lost
#8
Wayne R Cohen, Emanuel A Friedman
Implementation of clinical practice guidelines may moderate health care costs, improve care, reduce medicolegal liability, and provide a uniformity in care allowing meaningful investigation of treatments and outcomes. However, new guidelines are often uncritically embraced by clinicians, risk management organizations, insurance companies, and the courts as the standard of care. Adoption of incompletely vetted recommendations can lead to patient harm. Recent recommendations made by the American College of Obstetricians and Gynecologists and the Society for Maternal-Fetal Medicine for assessment and management of labor provide an example of well-intended guidelines adopted uncritically...
November 15, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29137965/a-novel-bagging-c4-5-algorithm-based-on-wrapper-feature-selection-for-supporting-wise-clinical-decision-making
#9
Shin-Jye Lee, Zhaozhao Xu, Tong Li, Yun Yang
From the perspective of clinical decision-making in a Medical IoT-based healthcare system, achieving effective and efficient analysis of long-term health data for supporting wise clinical decision-making is an extremely important objective, but determining how to effectively deal with the multi-dimensionality and high volume of generated data obtained from Medical IoT-based healthcare systems is an issue of increasing importance in IoT healthcare data exploration and management. A novel classifier or predicator equipped with a good feature selection function contributes effectively to classification and prediction performance...
November 11, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29134532/a-robust-multi-objective-bargaining-methodology-for-inter-basin-water-resource-allocation-a-case-study
#10
Omid Nasiri-Gheidari, Safar Marofi, Farzaneh Adabi
In this study, a new methodology is proposed to balance environmental and economic issues in water allocation under uncertainty. Two objective functions, including maximizing economic income (EI) and minimizing environmental pollution (EP), were considered as two groups of players to construct a deterministic multi-objective bargaining methodology (DMOBM). In the next step, it is enhanced to a robust multi-objective bargaining methodology (RMOBM), which is capable of incorporating the main uncertainties exist in the problem...
November 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29132378/protocol-for-the-study-of-self-perceived-psychological-and-emotional-well-being-of-young-paralympic-athletes
#11
Luca Puce, Lucio Marinelli, Laura Mori, Ilaria Pallecchi, Carlo Trompetto
BACKGROUND: We present the detailed protocol set up to investigate how agonistic sport affects the self-perceived psychological and emotional well-being of disabled young people. METHODS: The study will be carried out on a number of subjects as large as 800-1200, using well-established indices that give a quantitative measure of such well-being, namely SF-12 and PGWBI. The related questionnaires will be administered to the participants to a forthcoming international event, the European Para-Youth Games, 9-15 October 2017, Liguria, Italy, as well as to a reference population of a similar number of subjects, made up of young disabled people that do not practice agonistic sport...
November 13, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29129715/reducing-barriers-to-healthy-weight-planned-and-responsive-adaptations-to-a-lifestyle-intervention-to-serve-people-with-impaired-mobility
#12
Andrea C Betts, Katherine Froehlich-Grobe, Simon Driver, Danielle Carlton, M Kaye Kramer
BACKGROUND: People with impaired mobility (IM) disabilities have a higher prevalence of obesity and obesity-related chronic conditions; however, lifestyle interventions that address the unique needs of people with IM are lacking. OBJECTIVE: This paper describes an adapted evidence-based lifestyle intervention developed through community-based participatory research (CBPR). METHODS: Individuals with IM, health professionals, disability group representatives, and researchers formed an advisory board to guide the process of thoroughly adapting the Diabetes Prevention Program Group Lifestyle Balance (DPP GLB) intervention after a successful pilot in people with IM...
October 27, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/29129697/dual-mechanisms-for-balancing-th17-and-treg-cell-fate-by-creb
#13
Antony Symons, Wenjun Ouyang
Th17 cells, which express the cytokine IL-17A, and master regulator RORγt, are important in the inflammatory response to fungal and bacterial pathogens, but also have a pathogenic role in many inflammatory disorders. In contrast, regulatory T cells (Treg), expressing the Foxp3 transcription factor, have a suppressive function and can dampen an immune response. The appropriate balance of these distinct effector functions is critical for an effective immune response and autoimmunity can arise if this process goes awry...
November 9, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29124717/semantic-ambiguity-effects-on-traditional-chinese-character-naming-a-corpus-based-approach
#14
Ya-Ning Chang, Chia-Ying Lee
Words are considered semantically ambiguous if they have more than one meaning and can be used in multiple contexts. A number of recent studies have provided objective ambiguity measures by using a corpus-based approach and have demonstrated ambiguity advantages in both naming and lexical decision tasks. Although the predictive power of objective ambiguity measures has been examined in several alphabetic language systems, the effects in logographic languages remain unclear. Moreover, most ambiguity measures do not explicitly address how the various contexts associated with a given word relate to each other...
November 9, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/29124449/the-evolution-of-public-health-ethics-frameworks-systematic-review-of-moral-values-and-norms-in-public-health-policy
#15
REVIEW
Mahmoud Abbasi, Reza Majdzadeh, Alireza Zali, Abbas Karimi, Forouzan Akrami
Given the evolution of the public health (PH) and the changes from the phenomenon of globalization, this area has encountered new ethical challenges. In order to find a coherent approach to address ethical issues in PH policy, this study aimed to identify the evolution of public health ethics (PHE) frameworks and the main moral values and norms in PH practice and policy. According to the research questions, a systematic search of the literature, in English, with no time limit was performed using the main keywords in databases Web of Science (ISI) and PubMed...
November 9, 2017: Medicine, Health Care, and Philosophy
https://www.readbyqxmd.com/read/29122975/efficiency-and-thoroughness-trade-offs-in-high-volume-organisational-routines-an-ethnographic-study-of-prescribing-safety-in-primary-care
#16
Suzanne Grant, Bruce Guthrie
BACKGROUND: Prescribing is a high-volume primary care routine where both speed and attention to detail are required. One approach to examining how organisations approach quality and safety in the face of high workloads is Hollnagel's Efficiency and Thoroughness Trade-Off (ETTO). Hollnagel argues that safety is aligned with thoroughness and that a choice is required between efficiency and thoroughness as it is not usually possible to maximise both. This study aimed to ethnographically examine the efficiency and thoroughness trade-offs made by different UK general practices in the achievement of prescribing safety...
November 9, 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/29121901/couple-s-concordance-and-discordance-in-household-decision-making-and-married-women-s-use-of-modern-contraceptives-in-bangladesh
#17
Jalal Uddin, Muhammad Zakir Hossin, Mohammad Habibullah Pulok
BACKGROUND: Although a large body of studies documents that women's autonomy in the household is associated with better reproductive health outcomes, these studies typically examined autonomy only from women's point of view. The current study employs husband's and wife's perspectives together to examine the relationship between the decision-making arrangements in the household and the women's use of modern contraceptives in Bangladesh. METHODS: The study used the couple dataset of 2007 Bangladesh Demographic and Health Survey...
November 9, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/29120895/leaving-the-nest-anticipatory-guidance-for-the-college-bound-youth
#18
Sharnendra Sidhu, Andrew Adesman
PURPOSE OF REVIEW: The number of students enrolling in college is on the rise; however, the number of students dropping out is increasing as well. Given that the transition to attending college poses challenges with independent academic functioning, social adjustment, health behaviors, and lifestyle choices, the purpose of this review is to describe some of the issues that these students will encounter so that pediatricians can help teens who are going to college successfully transition to their new academic, social, and living environment...
December 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29113451/forum-editorial-nicotine-adenine-dinucleotides-the-redox-currency-of-the-cell
#19
Joshua P Fessel, William M Oldham
There has been tremendous and rapidly growing interest in understanding intermediary metabolism as a key aspect of both normal cellular function and as a participant in the molecular pathogenesis of many different complex diseases. This area of research naturally intersects at virtually every level with the substantial and expanding body of knowledge regarding mechanisms of cellular redox balance. In this Forum Issue, the contributing authors address specifically the union of intermediary metabolism and redox biology through detailed consideration of the biochemistry and biology of nicotine adenine dinucleotides, the cell's "redox currency...
November 7, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29110730/a-meta-science-for-a-global-bioethics-and-biomedicine
#20
David S Basser
BACKGROUND: As suggested by Shook and Giordano, understanding and therefore addressing the urgent international governance issues around globalizing bio-medical/technology research and applications is limited by the perception of the underlying science. METHODS: A philosophical methodology is used, based on novel and classical philosophical reflection upon existent literature, clinical wisdoms and narrative theory to discover a meta-science and telos of humankind for the development of a relevant and defendable global biomedical bioethics...
November 7, 2017: Philosophy, Ethics, and Humanities in Medicine: PEHM
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