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https://www.readbyqxmd.com/read/28924523/the-interplay-of-genetics-and-environmental-factors-in-the-development-of-obesity
#1
REVIEW
Abu Baker Sheikh, Adeel Nasrullah, Shujaul Haq, Aisha Akhtar, Haider Ghazanfar, Amara Nasir, Rao M Afzal, Marvi M Bukhari, Ahtsham Yousaf Chaudhary, Syed W Naqvi
Obesity is a major health issue in the developed nations, and it has been increasingly clear that both genetics and environment play an important role in determining if an individual will be obese or not. We reviewed the latest researches which were carried out to identify the obesity susceptible genes and to identify the metabolic pathways having a central role in energy balance. Obesity is a heritable disorder, and some of the many obesity susceptible genes are fat mass and obesity (FTO), leptin, and Melanocortin-4 receptor (MC4R)...
July 6, 2017: Curēus
https://www.readbyqxmd.com/read/28924492/the-essentials-of-a-global-index-for-cognitive-function
#2
Joseph Mathew Antony, Ian Weaver, Matthew Rueffer, Najla Guthrie, Malkanthi Evans
Cognition is comprised of the faculties: perception, creativity, intuition, and ratiocination. Optimal levels of cognition are needed for independent functioning and balanced living. With an aging population that continues to grow, dietary supplements that tilt the balance towards maintenance of cognition are being marketed for vulnerable populations facing these challenges. Randomized clinical trials provide the causal inference necessary to define the efficacy of emerging nutraceuticals. Cognition testing, in particular, requires a battery of tests that encompass all brain regions involved in cognition so as to provide endpoints necessary for product validation...
2017: Translational Neuroscience
https://www.readbyqxmd.com/read/28924245/understanding-the-factors-affecting-self-management-of-copd-from-the-perspectives-of-healthcare-practitioners-a-qualitative-study
#3
Oladapo J Ogunbayo, Sian Russell, James J Newham, Karen Heslop-Marshall, Paul Netts, Barbara Hanratty, Eileen Kaner
Self-management is recognised as an essential criteria for the provision of high quality care for chronic obstructive pulmonary disease (COPD). The management of COPD is usually delivered by a wide range of healthcare practitioners. This study aimed to understand the factors affecting self-management of COPD from the perspectives of the different multidisciplinary healthcare teams involved in COPD care. Semi-structured interviews were conducted with participants from primary care, specialist respiratory and pulmonary rehabilitation (PR) teams...
September 18, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28917238/qualitative-study-of-eating-habits-in-bruneian-primary-school-children
#4
Tajidah Talip, Rajiah Serudin, Salmah Noor, Nik Tuah
BACKGROUND AND OBJECTIVES: Childhood obesity is a serious public health issue globally and poor eating habits are an important contributing factor. This study aimed to explore the perceptions, practices and attitudes towards healthy eating in Bruneian primary school children. METHODS AND STUDY DESIGN: A qualitative study was conducted among 40 subjects involving 18 children (aged 9-10 years old), 12 parents and 10 teachers, who were recruited from two primary schools using convenience sampling...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28914718/balance-evaluation-of-prefrail-and-frail-community-dwelling-older-adults
#5
Larissa Tomasauskas Marques, Natalia Camargo Rodrigues, Emanuella Oliveira Angeluni, Fernanda Pinheiro Amador Dos Santos Pessanha, Natália Maira da Cruz Alves, Renato Campos Freire Júnior, Eduardo Ferriolli, Daniela Cristina Carvalho de Abreu
BACKGROUND AND PURPOSE: With the increase in the percentage of the population in older adulthood, issues such as frailty syndrome need to be considered. The aim of the present study was to evaluate the ability of the Balance Evaluation Systems Test (BESTest) and center of pressure (COP) in their ability to discriminate between nonfrail, prefrail, and frail older adults. The proposed hypothesis is that frail older adults would show poorer performance in BESTest tasks and higher oscillation of COP on a force platform...
September 13, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/28913899/genotyping-by-sequencing-through-transcriptomics-implementation-in-a-range-of-crop-species-with-varying-reproductive-habits-and-ploidy-levels
#6
Michelle M Malmberg, Luke W Pembleton, Rebecca C Baillie, Michelle C Drayton, Shimna Sudheesh, Sukhjiwan Kaur, Hiroshi Shinozuka, Preeti Verma, German C Spangenberg, Hans D Daetwyler, John W Forster, Noel O I Cogan
The application of genomics in crops has the ability to significantly improve genetic gain for agriculture. Many marker-dense tools have been developed but few have seen broad adoption in plant genomics due to issues of significant variations of genome size, levels of ploidy, single nucleotide polymorphism (SNP) frequency and reproductive habit. When combined with limited breeding activities, small research communities and scant sequence resources, the suitability of popular systems is often sub-optimal and routinely fails to effectively balance cost-effectiveness and sample throughput...
September 15, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28913648/combined-effect-of-the-saccharomyces-cerevisiae-lag-phase-and-the-non-saccharomyces-consortium-to-enhance-wine-fruitiness-and-complexity
#7
Warren Albertin, Adrien Zimmer, Cécile Miot-Sertier, Margaux Bernard, Joana Coulon, Virginie Moine, Benoit Colonna-Ceccaldi, Marina Bely, Philippe Marullo, Isabelle Masneuf-Pomarede
Non-Saccharomyces (NS) species that are either naturally present in grape must or added in mixed fermentation with S. cerevisiae may impact the wine's chemical composition and sensory properties. NS yeasts are prevailing during prefermentation and early stages of alcoholic fermentation. However, obtaining the correct balance between S. cerevisiae and NS species is still a critical issue: if S. cerevisiae outcompetes the non-Saccharomyces, it may minimize their impact, while conversely if NS take over S. cerevisiae, it may result in stuck or sluggish fermentations...
September 14, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28912551/the-antipsychotic-drugs-olanzapine-and-haloperidol-modify-network-connectivity-and-spontaneous-activity-of-neural-networks-in-vitro
#8
Egor Dzyubenko, Georg Juckel, Andreas Faissner
Impaired neural synchronization is a hallmark of psychotic conditions such as schizophrenia. It has been proposed that schizophrenia-related cognitive deficits are caused by an unbalance of reciprocal inhibitory and stimulatory signaling. This supposedly leads to decreased power of induced gamma oscillations during the performance of cognitive tasks. In light of this hypothesis an efficient antipsychotic treatment should modify the connectivity and synchronization of local neural circuits. To address this issue, we investigated a model of hippocampal neuronal networks in vitro...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28912288/sometimes-not-always-not-never-a-response-to-pickard-and-pearce
#9
Patrick J Sullivan
This paper provides a response to Hanna Pickard and Stephen Pearce's paper 'Balancing costs and benefits: a clinical perspective does not support a harm minimisation approach for self-injury outside of community settings.' This paper responded to my article 'Should healthcare professionals sometimes allow harm? The case of self-injury.' There is much in the paper that I would agree with, but I feel it is important to respond to a number of the criticisms of my paper in order to clarify my position and to facilitate ongoing debate in relation to this important issue...
September 14, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28905454/management-considerations-in-the-failing-renal-allograft
#10
REVIEW
Tom Lea-Henry, Bobby Chacko
Patients with a failed or failing renal transplant are increasing in number. Graft failure resulting in dialysis re-initiation is not uncommon, yet there are limited data to guide management of these patients. Physician practices vary regarding timing of dialysis initiation and the timing and extent of immunosuppression withdrawal. The risks of immunosuppression withdrawal need to be carefully balanced against the benefits of continuing low-dose therapy. The latter helps minimise the risk of sensitisation and has been proposed to possibly slow the loss of residual renal function; however, the use of common immunosuppressive agents may contribute to cardiovascular disease, malignancy, and infection, the major causes of death following the loss of a renal transplant...
September 14, 2017: Nephrology
https://www.readbyqxmd.com/read/28901341/-healthcare-services-citizen-s-right-and-healthcare-systems-safeguard-considerations-rising-from-the-charlie-gard-story
#11
Giuseppe R Gristina
The story of Charlie Gard, an 11-month-old boy suffering from a rare inherited mitochondrial disease called 'infantile encephalomyopathic mitochondrial DNA depletion syndrome' and kept alive thanks to life supports, rises some issues regarding the provision of healthcare. Is there a right of an individual person to buy any healthcare benefits only because he has enough money to do so? If the answer is 'yes', in light of the distributive justice principle how do governments balance this right with the obligation to regulate health care systems ensuring that all treatments are useful and affordable for everybody? Many considerations of the best interest of patients can be found in this debate, but we cannot ignore neither the value of the scientific method as the cornerstone of the medical profession nor a commitment to support the moral integrity of clinical practice by refusing to provide treatments that do not meet a reasonable threshold of scientific justification evidence-based...
September 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28899406/forecasting-the-regional-distribution-and-sufficiency-of-physicians-in-japan-with-a-coupled-system-dynamics-geographic-information-system-model
#12
Tomoki Ishikawa, Kensuke Fujiwara, Hisateru Ohba, Teppei Suzuki, Katsuhiko Ogasawara
BACKGROUND: In Japan, the shortage of physicians has been recognized as a major medical issue. In our previous study, we reported that the absolute shortage will be resolved in the long term, but maldistribution among specialties will persist. To address regional shortage, several Japanese medical schools increased existing quota and established "regional quotas." This study aims to assist policy makers in designing effective policies; we built a model for forecasting physician numbers by region to evaluate future physician supply-demand balances...
September 12, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/28895380/how-to-optimize-the-lung-donor
#13
Gabriele Sales, Andrea Costamagna, Vito Fanelli, Massimo Boffini, Francesco Pugliese, Luciana Mascia, Luca Brazzi
In the last two decades, lung transplantation emerged as the standard of care for patients with advanced and terminal lung disease. Despite the increment in lung transplantation rates, in 2016 the overall mortality while on waiting list in Italy reached the 10%, whereas only the 39% of the wait-list patients were successfully transplanted. A number of approaches, including protective ventilatory strategy, accurate management of fluid balance, administration of a hormonal resuscitation therapy have been reported to improve lung donor performance before organ retrieval...
September 11, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28893944/making-a-virtue-of-necessity-the-pleiotropic-role-of-human-endogenous-retroviruses-in-cancer
#14
REVIEW
George Kassiotis, Jonathan P Stoye
Like all other mammals, humans harbour an astonishing number of endogenous retroviruses (ERVs), as well as other retroelements, embedded in their genome. These remnants of ancestral germline infection with distinct exogenous retroviruses display various degrees of open reading frame integrity and replication capability. Modern day exogenous retroviruses, as well as the infectious predecessors of ERVs, are demonstrably oncogenic. Further, replication-competent ERVs continue to cause cancers in many other species of mammal...
October 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28893768/building-managed-primary-care-practice-networks-to-deliver-better-clinical-care-a-qualitative-semi-structured-interview-study
#15
Jasmine Pawa, John Robson, Sally Hull
BACKGROUND: Primary care practices are increasingly working in larger groups. In 2009, all 36 primary care practices in the London borough of Tower Hamlets were grouped geographically into eight managed practice networks to improve the quality of care they delivered. Quantitative evaluation has shown improved clinical outcomes. AIM: To provide insight into the process of network implementation, including the aims, facilitating factors, and barriers, from both the clinical and managerial perspectives...
September 11, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28892556/parenteral-anticoagulation-in-ambulatory-patients-with-cancer
#16
REVIEW
Elie A Akl, Lara A Kahale, Maram B Hakoum, Charbel F Matar, Francesca Sperati, Maddalena Barba, Victor E D Yosuico, Irene Terrenato, Anneliese Synnot, Holger Schünemann
BACKGROUND: Anticoagulation may improve survival in patients with cancer through a speculated anti-tumour effect, in addition to the antithrombotic effect, although may increase the risk of bleeding. OBJECTIVES: To evaluate the efficacy and safety of parenteral anticoagulants in ambulatory patients with cancer who, typically, are undergoing chemotherapy, hormonal therapy, immunotherapy or radiotherapy, but otherwise have no standard therapeutic or prophylactic indication for anticoagulation...
September 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28890597/women-s-land-tenure-security-and-household-human-capital-evidence-from-ethiopia-s-land-certification
#17
Felix M Muchomba
This paper examines the impact of Ethiopia's gendered land certification programs on household consumption of healthcare, food, education, and clothing. Ethiopia embarked on a land tenure reform program in 1998, after years of communism during which all land was nationalized. The reform began in Tigray region where land certificates were issued to household heads, who were primarily male. In a second phase carried out in 2003-2005, three other regions issued land certificates jointly to household heads and spouses, presenting variation in land tenure security by gender...
October 2017: World Development
https://www.readbyqxmd.com/read/28888583/food-and-drug-administration-warning-on-anesthesia-and-brain-development-implications-for-obstetric-and-fetal-surgery
#18
Olutoyin A Olutoye, Byron Wycke Baker, Michael A Belfort, Oluyinka O Olutoye
There has been growing concern about the detrimental effects of certain anesthetic agents on the developing brain. Preclinical studies in small animal models as well as nonhuman primates suggested loss or death of brain cells and consequent impaired neurocognitive function following anesthetic exposure in neonates and late gestation fetuses. Human studies in this area are limited and currently inconclusive. On Dec. 14, 2016, the US Food and Drug Administration issued a warning regarding impaired brain development in children following exposure to certain anesthetic agents used for general anesthesia, namely the inhalational anesthetics isoflurane, sevoflurane, and desflurane, and the intravenous agents propofol and midazolam, in the third trimester of pregnancy...
September 6, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28887887/evaluating-the-essential-role-of-rons-in-vivo-in-exercised-human-muscle
#19
EDITORIAL
Enrique Jaimovich, Mariana Casas
An article by Margaritelis et al.,(1) (this issue) addresses an important issue in exercise physiology, as it is the actual role of reactive oxygen and nitrogen species (RONS) in exercise-induced adaptations in humans. The authors designed a procedure that allowed them to avoid the use of exogenous anti-oxidants and redox agents that will normally alter metabolism and have multiple undesired effects. We discuss here in the context of the necessary balance between the beneficial role of reactive oxygen and nitrogen species as intracellular signals for muscle adaptation and the deleterious effects of these species in oxidative stress...
September 9, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28887420/the-flexibility-rigidity-coordination-of-dense-exopolysaccharide-matrix-in-terrestrial-cyanobacteria-acclimated-to-periodic-desiccation
#20
Wen Liu, Lijuan Cui, Haiyan Xu, Zhaoxia Zhu, Xiang Gao
A dense exopolysaccharide (EPS) matrix is crucial for cyanobacterial survival in terrestrial xeric environments, in which cyanobacteria undergo frequent expansion and shrinkage processes during environmental desiccation-rehydration cycles. However, it is unclear how terrestrial cyanobacteria coordinate the structural dynamics of the EPS matrix upon the expansion and shrinkage to avoid potential mechanical stress while benefiting from the matrix. In the present study, we sought to answer this question by investigating the gene expression, protein dynamics, enzymatic characteristics and biological roles of WSPA, an abundantly secreted protein, in the representative terrestrial cyanobacterium Nostoc flagelliforme The results demonstrated that WSPA is a novel β-galactosidase that facilitates softening of the EPS matrix by breaking the polysaccharide backbone under substantial moisture or facilitates the thickening and re-linkage of the broken matrix upon drying process, and thus these regulations are well correlated with moisture availability or desiccation-rehydration cycles...
September 8, 2017: Applied and Environmental Microbiology
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