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https://www.readbyqxmd.com/read/29351127/four-months-of-wearing-a-balance-orthotic-improves-measures-of-balance-and-mobility-among-a-cohort-of-community-living-older-adults
#1
Sean Noah, Cynthia Gibson-Horn, Jennifer L Vincenzo
BACKGROUND AND PURPOSE: The Centers for Disease Control and Prevention estimated that there were 29 million falls and 7 million injuries in 2014 in the United States. Falls, decreased balance, and mobility disability are common in older adults and often result in loss of independence. Finding interventions to address these issues is important, as this age group is growing exponentially. Prior studies indicate balance and mobility can be improved by the balance-based torso-weighting (BBTW) assessment implemented through wear of a balance orthotic (BO)...
January 18, 2018: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/29348656/quantifying-the-risk-and-cost-of-active-monitoring-for-infectious-diseases
#2
Nicholas G Reich, Justin Lessler, Jay K Varma, Neil M Vora
During outbreaks of deadly emerging pathogens (e.g., Ebola, MERS-CoV) and bioterror threats (e.g., smallpox), actively monitoring potentially infected individuals aims to limit disease transmission and morbidity. Guidance issued by CDC on active monitoring was a cornerstone of its response to the West Africa Ebola outbreak. There are limited data on how to balance the costs and performance of this important public health activity. We present a framework that estimates the risks and costs of specific durations of active monitoring for pathogens of significant public health concern...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29347051/enhanced-capital-asset-pricing-model-for-the-reconstruction-of-bipartite-financial-networks
#3
Tiziano Squartini, Assaf Almog, Guido Caldarelli, Iman van Lelyveld, Diego Garlaschelli, Giulio Cimini
Reconstructing patterns of interconnections from partial information is one of the most important issues in the statistical physics of complex networks. A paramount example is provided by financial networks. In fact, the spreading and amplification of financial distress in capital markets are strongly affected by the interconnections among financial institutions. Yet, while the aggregate balance sheets of institutions are publicly disclosed, information on single positions is mostly confidential and, as such, unavailable...
September 2017: Physical Review. E
https://www.readbyqxmd.com/read/29345524/recovery-and-performance-in-sport-consensus-statement
#4
Michael Kellmann, Maurizio Bertollo, Laurent Bosquet, Michel Brink, Aaron Coutts, Rob Duffield, Daniel Erlacher, Shona Halson, Anne Hecksteden, Jahan Heidari, Romain Meeusen, Iñigo Mujika, Claudio Robazza, Sabrina Skorski, Ranel Venter, Jürgen Beckmann
The relationship between recovery and fatigue and its impact on performance has attracted the interest of sports science for many years. An adequate balance between stress (training and competition load, other life demands) and recovery is essential for athletes to achieve continuous high-level performance. Research has focused on the examination of physiological and psychological recovery strategies to compensate external and internal training and competition loads. A systematic monitoring of recovery and the subsequent implementation of recovery routines aims at maximizing performance and preventing negative developments such as underrecovery, non-functional overreaching, the overtraining syndrome, injuries, or illnesses...
January 18, 2018: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29344455/qualitative-assessment-of-learning-strategies-among-medical-students-using-focus-group-discussions-and-in-depth-interviews
#5
Anuradha Sujai Joshi, Jaishree Deepak Ganjiwale, Jagdish Varma, Praveen Singh, Jyoti Nath Modi, Tejinder Singh
Background: Globally, students with top academic performance and high intellectual capacity usually opt to study medicine. However, once students get enrolled, their academic performance varies widely. Such variations appear to be determined by various factors, one of them being types of learning strategies adopted by students. The learning strategies utilized by the students with better academic performance are likely to be more effective learning strategies. Aims and Objectives: The objective is to identify effective learning strategies used by medical students...
December 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/29341909/nanogel-dfo-conjugates-as-a-model-to-investigate-pharmacokinetics-biodistribution-and-iron-chelation-in-vivo
#6
Yan Wang, Zhi Liu, Tien-Min Lin, Shaurya Chanana, May P Xiong
Deferoxamine (DFO) to treat iron overload (IO) has been limited by toxicity issues and short circulation times and it would be desirable to prolong circulation to improve non-transferrin bound iron (NTBI) chelation. In addition, DFO is currently unable to efficiently target the large pool of iron in the liver and spleen. Nanogel-Deferoxamine conjugates (NG-DFO) can prove useful as a model to investigate the pharmacokinetic (PK) properties and biodistribution (BD) behavior of iron-chelating macromolecules and their overall effect on serum ferritin levels...
January 13, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29337086/incidental-pulmonary-nodules-are-common-on-ct-coronary-angiogram-and-have-a-significant-cost-impact
#7
James Robertson, Sandra Nicholls, Philip Bardin, Ronnie Ptasznik, Daniel Steinfort, Alistair Miller
BACKGROUND: Computed tomography (CT) coronary angiogram (CTCA) is commonly used for diagnostic evaluation of low-moderate risk patients due to its excellent performance and cost-effectiveness. However, previous cost analyses have not factored in the burden of management of pulmonary nodules, which are a common occurrence. We sought to describe the frequency and characteristics of lung nodules on CTCA in an Australian tertiary hospital, and to assess cost impacts. METHODS: Consecutive CTCAs performed in the calendar year 2012 were retrospectively identified from the imaging department database...
December 5, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29336331/-job-status-after-the-resident-training-period-in-spain-analysis-of-a-national-survey
#8
Miguel García Sanz, Moises Rodríguez Socarrás, Leonardo Tortolero Blanco, Laura Pesquera-Ortega, Juan Colombo, Juan Gómez Rivas
OBJECTIVES: Since the establishment of specialization of medicine through the residency system, Spanish health care has sought to maintain a balance between established needs and trained professionals, with the aim of avoiding the deficit or excess of health specialists with its consequences. The objective of the present review is to know the working conditions of urologist specialists at the end of the residency training period. METHODS: The results of a survey for urologist who completed their residency contract from 2012 to 2016 are presented, assessing working status, academic and working data during the first months after the completion of specialized training...
January 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29335368/in-medio-stat-virtus-unanticipated-consequences-of-telomere-dysequilibrium
#9
REVIEW
Lea Harrington, Fabio Pucci
The integrity of chromosome ends, or telomeres, depends on myriad processes that must balance the need to compact and protect the telomeric, G-rich DNA from detection as a double-stranded DNA break, and yet still permit access to enzymes that process, replicate and maintain a sufficient reserve of telomeric DNA. When unable to maintain this equilibrium, erosion of telomeres leads to perturbations at or near the telomeres themselves, including loss of binding by the telomere protective complex, shelterin, and alterations in transcription and post-translational modifications of histones...
March 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29335013/fit-for-function-study-protocol-for-a-randomized-controlled-trial
#10
Julie Richardson, Ada Tang, Gordon Guyatt, Lehana Thabane, Feng Xie, Demetrios Sahlas, Robert Hart, Rebecca Fleck, Genevieve Hladysh, Louise Macrae
BACKGROUND: The current state of evidence suggests that community-based exercise programs are beneficial in improving impairment, function, and health status, and are greatly needed for persons with stroke. However, limitations of these studies include risk of bias, feasibility, and cost issues. METHODS/DESIGN: This single-blinded, randomized controlled trial (RCT) of 216 participants with stroke will compare the effectiveness of a 12-week YMCA community-based wellness program (FIT for FUNCTION) specifically designed for community-dwelling persons with stroke to persons who receive a standard YMCA membership...
January 15, 2018: Trials
https://www.readbyqxmd.com/read/29332618/online-market-research-panel-members-as-controls-in-case-control-studies-to-investigate-gastrointestinal-disease-outbreaks-early-experiences-and-lessons-learnt-from-the-uk
#11
P Mook, J McCormick, S Kanagarajah, G K Adak, P Cleary, R Elson, M Gobin, J Hawker, T Inns, C Sinclair, S C M Trienekens, R Vivancos, N D McCarthy
Established methods of recruiting population controls for case-control studies to investigate gastrointestinal disease outbreaks can be time consuming, resulting in delays in identifying the source or vehicle of infection. After an initial evaluation of using online market research panel members as controls in a case-control study to investigate a Salmonella outbreak in 2013, this method was applied in four further studies in the UK between 2014 and 2016. We used data from all five studies and interviews with members of each outbreak control team and market research panel provider to review operational issues, evaluate risk of bias in this approach and consider methods to reduce confounding and bias...
January 15, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29330559/a-post-translational-balancing-act-the-good-and-the-bad-of-sumoylation-in-pancreatic-islets
#12
EDITORIAL
Patrick E MacDonald
Post-translational modification of proteins contributes to the control of cell function and survival. The balance of these in insulin-producing pancreatic beta cells is important for the maintenance of glucose homeostasis. Protection from the damaging effects of reactive oxygen species is required for beta cell survival, but if this happens at the expense of insulin secretory function then the ability of islets to respond to changing metabolic conditions may be compromised. In this issue of Diabetologia, He et al ( https://doi...
January 12, 2018: Diabetologia
https://www.readbyqxmd.com/read/29330237/-the-hand-on-the-doorknob-visit-agenda-setting-by-complex-patients-and-their-primary-care-physicians
#13
Christine P Kowalski, Deanna B McQuillan, Neetu Chawla, Courtney Lyles, Andrea Altschuler, Connie S Uratsu, Elizabeth A Bayliss, Michele Heisler, Richard W Grant
BACKGROUND: Choosing which issues to discuss in the limited time available during primary care visits is an important task for complex patients with chronic conditions. DESIGN, SETTING, AND PARTICIPANTS: We conducted sequential interviews with complex patients (n = 40) and their primary care physicians (n = 17) from 3 different health systems to investigate how patients and physicians prepare for visits, how visit agendas are determined, and how discussion priorities are established during time-limited visits...
January 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29327636/the-norwegian-occupational-wholeness-questionnaire-n-owq-scale-development-and-psychometric-properties
#14
Tore Bonsaksen, Farzaneh Yazdani
BACKGROUND: Occupational therapy has long emphasized the concepts doing, being, becoming and belonging, and a notion of balance between them. Measures of these concepts are in a developing stage. AIM: This study aimed to develop and examine the properties of the Norwegian version of the Occupational Wholeness Questionnaire (N-OWQ), which is proposed to measure being, becoming, and belonging, in addition to occupational wholeness as a higher-order concept. METHODS: An anonymous sample of 248 persons over the age of 18 years completed the N-OWQ along with sociodemographic information...
January 12, 2018: Scandinavian Journal of Occupational Therapy
https://www.readbyqxmd.com/read/29326837/one-stage-approach-for-hybrid-atrial-fibrillation-treatment
#15
Vincent Umbrain, Christian Verborgh, Gian-Battista Chierchia, Carlo De Asmundis, Pedro Brugada, Mark La Meir
The one-stage approach for hybrid atrial fibrillation involves the simultaneous and close cooperation of different medical specialties. This review attempts to describe its challenging issues, exposing a plan to balance thrombotic risk and bleeding risk. It describes the combined surgical-electrophysiological procedure. Specific topics, involving hemodynamic, fluid and respiratory management during surgery are considered, and problems related to postoperative pain are surveyed.
December 2017: Arrhythmia & Electrophysiology Review
https://www.readbyqxmd.com/read/29325345/-important-issues-need-to-be-emphasized-in-the-diagnosis-and-treatment-of-pancreatic-cystic-neoplasms
#16
W H Lou, Y P Zhao
The patients of pancreatic cystic neoplasms diagnosed and treated are increasing over the past decade. Recent and long-tern risk and benefit should be well balanced when considering treatment, follow the principle of patient-benefit. For low malignancy potential neoplasm like serous cystic tumor or branch duct intraductal papillary mucinous neoplasm, surgical indication should be reserved to those with obvious malignant potential.Decreasing perioperative mortality and morbidity should be emphasized. Comprehensive studies are needed to validate the efficacy of new diagnostic and treatment technique before applied to clinical...
January 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29322610/safety-and-efficacy-of-once-weekly-semaglutide-versus-additional-oral-antidiabetic-drugs-in-japanese-subjects-with-inadequately-controlled-t2d-a-randomised-trial
#17
Kohei Kaku, Yuichiro Yamada, Hirotaka Watada, Atsuko Abiko, Tomoyuki Nishida, Jeppe Zacho, Arihiro Kiyosue
AIMS: Semaglutide is a glucagon-like peptide 1 analogue in development for type 2 diabetes (T2D). Safety and efficacy of once-weekly subcutaneous semaglutide as monotherapy or combined with an oral antidiabetic drug (OAD) vs an additional OAD was evaluated in Japanese subjects with T2D inadequately controlled on diet/exercise or OAD monotherapy. METHODS: In this phase 3, open-label trial, adults with T2D were randomised 2:2:1 to semaglutide 0.5 mg or 1.0 mg, or one additional OAD (dipeptidyl peptidase-4 inhibitor, biguanide, sulphonylurea, glinide, α-glucosidase inhibitor or thiazolidinedione) with different modes of action...
January 11, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29322310/relationship-between-sagittal-spinal-curves-geometry-and-isokinetic-trunk-muscle-strength-in-adults
#18
Walaa Elsayed, Ahmed Farrag, Qassim Muaidi, Nora Almulhim
PURPOSE: Sagittal spinal deviation has been reported to be a significant musculoskeletal problem affecting both genders and could develop at any age. Factors triggering this issue are still not well defined. The purpose of this study was to investigate the relationship between sagittal spine angles and isokinetic peak, average torque, and power of trunk muscles in asymptomatic adults. METHODS: A convenient sample of 79 subjects with asymptomatic spine participated in this study...
January 10, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29319445/development-of-a-taxonomy-of-practice-related-stressors-experienced-by-veterinarians-in-the-united-states
#19
Olivia H Vande Griek, Malissa A Clark, Tracy K Witte, Randall J Nett, Amanda N Moeller, Margaret E Stabler
OBJECTIVE To develop a comprehensive taxonomy of practice-related stressors experienced by US veterinarians. DESIGN Cross-sectional survey. SAMPLE A subset of 1,422 US veterinarians who provided written (vs selected) responses to a question in a previous survey regarding practice-related stressors. PROCEDURES Using grounded theory analysis, 3 researchers inductively analyzed written survey responses concerning respondents' main practice-related stressors. In 5 iterations, responses were individually coded and categorized, and a final list of practice-related stressor categories and subcategories was iteratively and collaboratively developed until theoretical and analytic saturation of the data was achieved...
January 15, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29318953/auto-driven-photo-elicitation-interviews-in-research-with-children-ethical-and-practical-considerations
#20
Karen Ford, Lucy Bray, Tineke Water, Annette Dickinson, Janine Arnott, Bernie Carter
Children can sometimes find it difficult to articulate their experiences if they have to rely solely on words. Giving children the opportunity to use arts-based research approaches can support their participation in research and create a bridge that enables them to express their perspectives and feelings. This paper focuses on the ethical and practical considerations when using photo elicitation interviews (PEI) in research with children. The discussion and examples provided are drawn from an international study that used auto-driven PEI, where photographs are taken by children themselves, to explore children's experiences of living with a chronic condition and the impact condition management may have on their everyday lives...
June 2017: Comprehensive Child and Adolescent Nursing
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