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https://www.readbyqxmd.com/read/27904649/fasciocutaneous-flap-reinforcement-of-ventral-onlay-buccal-mucosa-grafts-enables-neophallus-revision-urethroplasty
#1
Stelios C Wilson, John T Stranix, Kiranpreet Khurana, Shane D Morrison, Jamie P Levine, Lee C Zhao
BACKGROUND: Urethral strictures or fistulas are common complications after phalloplasty. Neourethral defects pose a difficult reconstructive challenge using standard techniques as there is generally insufficient ventral tissue to support a graft urethroplasty. We report our experience with local fasciocutaneous flaps for support of ventrally-placed buccal mucosal grafts (BMGs) in phalloplasty. METHODS: A retrospective review of patients who underwent phalloplasty and subsequently required revision urethroplasty using BMGs between 2011 and 2015 was completed...
December 2016: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/27854157/measuring-fecal-testosterone-metabolites-in-spotted-hyenas-choosing-the-wrong-assay-may-lead-to-erroneous-results
#2
Susanne Pribbenow, Tulsidas G Shrivastav, Martin Dehnhard
Enzyme-immunoassays (EIA) that detect fecal testosterone metabolites (fTM) are powerful tools to monitor gonadal activity non-invasively. However, a challenge with testosterone EIAs might be their potential for cross-reactivities with structurally similar glucocorticoid metabolites. Therefore, we aimed to verify the capability of four different testosterone EIAs to monitor fTM without reflecting changes in adrenocortical activity in spotted hyenas by analyzing fecal samples following testosterone and ACTH challenge tests...
November 17, 2016: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/27844235/robot-assisted-laparoscopic-colpectomy-in-female-to-male-transgender-patients-technique-and-outcomes-of-a-prospective-cohort-study
#3
Freek Groenman, Charlotte Nikkels, Judith Huirne, Mick van Trotsenburg, Hans Trum
BACKGROUND: Gender-affirming surgeries in female-to-male (FtM) transgender patients include mostly hysterectomy, bilateral salpingo-oophorectomy and mastectomy. Sometimes further surgery is performed, such as phalloplasty. Colpectomy may be performed to overcome gender dysphoria and disturbing vaginal discharge; furthermore, it may be important in reducing the risk of fistulas due to the phalloplasty procedure with urethral elongation. Colpectomy prior to the reconstruction of the neourethra seems to reduce fistula rates on the very first anastomosis...
November 14, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27818844/a-pilot-study-of-botulinum-toxin-for-jerky-position-specific-upper-limb-action-tremor
#4
Tabish A Saifee, Tiago Teodoro, Roberto Erro, Mark J Edwards, Carla Cordivari
BACKGROUND: We aimed to investigate the efficacy and safety of botulinum toxin (BT) injections for jerky action tremor of the upper limb. METHODS: We performed an uncontrolled, prospective study of electromyography (EMG)-guided BT injections for jerky, position-specific, upper limb action tremor. The primary outcome was clinical global impression at 3-6 weeks after baseline. RESULTS: Eight patients with jerky, position-specific action tremor involving the upper limb were consecutively recruited...
2016: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/27815157/excretion-and-measurement-of-corticosterone-and-testosterone-metabolites-in-bank-voles-myodes-glareolus
#5
Saana Sipari, Hannu Ylönen, Rupert Palme
The bank vole is a commonly used model species in behavioral and ecophysiological studies. Thus, presenting a validated method for noninvasive monitoring of corticosterone and testosterone secretion is of high relevance. Here, we evaluated the effect of time of day and an ACTH challenge test on measured fecal corticosterone (FCM) and testosterone (FTM) metabolites in both sexes. Furthermore, we performed radiometabolism experiments for both steroids and sexes to study metabolism and excretion of (3)H-corticosterone and (3)H-testosterone...
November 1, 2016: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/27780883/human-umbilical-perivascular-cells-a-novel-source-of-mscs-to-support-testicular-niche-regeneration
#6
Leila Maghen, Ekaterina Shlush, Itai Gat, Melissa Filice, Tanya Barretto, Keith Jarvi, Kirk Lo, Andree S Gauthier-Fisher, Clifford L Librach
The expansion of functional testicular biopsy-derived human spermatogonial stem cells (hSSC) ex-vivo may enable the restoration of fertility in pre-pubertal males having undergone gonadotoxic therapies or men with severe male factor infertility. Various somatic cells are known to regulate SSC homeostasis and spermatogenesis in the developing and adult testis. Prior attempts to recapitulate this niche demonstrated the requirement of feeder cells, such as endogenous testicular somatic cells, for germ cell expansion ex-vivo...
October 25, 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/27744092/subcortical-gray-matter-changes-in-transgender-subjects-after-long-term-cross-sex-hormone-administration
#7
Rene Seiger, Andreas Hahn, Allan Hummer, Georg S Kranz, Sebastian Ganger, Michael Woletz, Christoph Kraus, Ronald Sladky, Alexander Kautzky, Siegfried Kasper, Christian Windischberger, Rupert Lanzenberger
Sex-steroid hormones are primarily involved in sexual differentiation and development and are thought to underlie processes related to cognition and emotion. However, divergent results have been reported concerning the effects of hormone administration on brain structure including side effects like brain atrophy and dementia. Cross-sex hormone therapy in transgender subjects offers a unique model for studying the effects of sex hormones on the living human brain. In this study, 25 Female-to-Male (FtM) and 14 Male-to-Female (MtF) subjects underwent MRI examinations at baseline and after a period of at least 4-months of continuous cross-sex hormone administration...
October 5, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27742823/the-variable-target-model-a-paradigm-shift-in-the-incremental-haemodialysis-prescription
#8
Francesco Gaetano Casino, Carlo Basile
BACKGROUND: The recent interest in incremental haemodialysis (HD) is hindered by the current prescription based on a fixed target model (FTM) for the total (dialytic + renal) equivalent continuous clearance (ECC). The latter is expressed either as standard Kt/V (stdKt/V), i.e. the pre-dialysis averaged concentration of urea-based ECC, or EKRc, i.e. the time averaged concentration-based ECC, corrected for volume (V) = 40 L. Accordingly, there are two different targets: stdKt/V = 2.3 volumes per week (v/wk) and EKRc = 13 mL/min/40 L...
October 14, 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/27705385/mapping-discrimination-experienced-by-indonesian-trans-ftm-persons
#9
Danny Gordon, Mario Prajna Pratama
This work sought to document how Indonesian trans* FtM persons experienced discrimination across the interlinked domains of social networks, religious and educational institutions, employment and the workplace, and health care institutions. Objectives were (1) to map the discrimination experienced by trans* FtM individuals in Indonesia, and (2) to establish the specific priorities of the Indonesian trans* FtM community. In-depth interviews, focus groups, and participant observation was used involving 14 respondents...
October 5, 2016: Journal of Homosexuality
https://www.readbyqxmd.com/read/27686883/patterns-of-sexual-behaviour-and-sexual-healthcare-needs-among-transgender-individuals-in-melbourne-australia-2011-2014
#10
Clare Bellhouse, Sandra Walker, Christopher K Fairley, Lenka A Vodstrcil, Catriona S Bradshaw, Marcus Y Chen, Eric P F Chow
OBJECTIVE: Literature surrounding the healthcare needs of transgender individuals is limited in Australia. This study aimed to investigate the demographic characteristics, risk behaviours and HIV/STI positivity among male-to-female (MTF) and female-to-male (FTM) transgender individuals attending Melbourne Sexual Health Centre (MSHC), Australia, between 2011 and 2014. METHOD: A retrospective cohort analysis for 133 transgender individuals was conducted based on the first visit of individuals to MSHC during the study period...
September 29, 2016: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/27646925/arterial-stiffness-and-arteriovenous-fistula-failure-of-maturation
#11
Agnes Masengu, Jennifer B Hanko, Alexander P Maxwell
PURPOSE: Increased arterial stiffness is a common finding in patients with end-stage renal disease. Following creation of an arteriovenous fistula (AVF), appropriate dilation of the feeding artery must occur to facilitate AVF maturation. Arterial stiffness may impair the arterial dilation required to facilitate AVF development and contribute to subsequent failure to mature (FTM). The aim of this pilot study was to investigate the association between measurements of central and peripheral arterial stiffness, and AVF FTM...
September 3, 2016: Journal of Vascular Access
https://www.readbyqxmd.com/read/27646840/altered-white-matter-and-sensory-response-to-bodily-sensation-in-female-to-male-transgender-individuals
#12
Laura K Case, David Brang, Rosalynn Landazuri, Pavitra Viswanathan, Vilayanur S Ramachandran
While most people take identification with their body for granted, conditions such as phantom limb pain, alien hand syndrome, and xenomelia suggest that the feeling of bodily congruence is constructed and susceptible to alteration. Individuals with xenomelia typically experience one of their limbs as over-present and aversive, leading to a desire to amputate the limb. Similarly, many transgender individuals describe their untreated sexed body parts as incongruent and aversive, and many experience phantom body parts of the sex they identify with (Ramachandran, 2008)...
September 19, 2016: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/27608463/unsupervised-3d-local-feature-learning-by-circle-convolutional-restricted-boltzmann-machine
#13
Zhizhong Han, Zhenbao Liu, Junwei Han, Chi-Man Vong, Shuhui Bu, Xuelong Li
Extracting local features from 3D shapes is an important and challenging task that usually requires carefully designed 3D shape descriptors. However, these descriptors are hand-crafted and require intensive human intervention with prior knowledge. To tackle this issue, we propose a novel deep learning model, namely Circle Convolutional Restricted Boltzmann Machine (CCRBM), for unsupervised 3D local feature learning. CCRBM is specially designed to learn from raw 3D representations. It effectively overcomes obstacles such as irregular vertex topology, orientation ambiguity on the 3D surface, and rigid or slightly non-rigid transformation invariance in the hierarchical learning of 3D data that cannot be resolved by the existing deep learning models...
September 2, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/27595141/a-systematic-review-of-the-effects-of-hormone-therapy-on-psychological-functioning-and-quality-of-life-in-transgender-individuals
#14
Jaclyn M White Hughto, Sari L Reisner
OBJECTIVES: To review evidence from prospective cohort studies of the relationship between hormone therapy and changes in psychological functioning and quality of life in transgender individuals accessing hormone therapy over time. DATA SOURCES: MEDLINE, PsycINFO, and PubMed were searched for relevant studies from inception to November 2014. Reference lists of included studies were hand searched. RESULTS: Three uncontrolled prospective cohort studies, enrolling 247 transgender adults (180 male-to-female [MTF], 67 female-to-male [FTM]) initiating hormone therapy for the treatment of gender identity disorder (prior diagnostic term for gender dysphoria), were identified...
January 2016: Transgender Health
https://www.readbyqxmd.com/read/27448372/stability-of-recurrent-neural-networks-with-time-varying-delay-via-flexible-terminal-method
#15
Zhanshan Wang, Sanbo Ding, Qihe Shan, Huaguang Zhang
This brief is concerned with the stability criteria for recurrent neural networks with time-varying delay. First, based on convex combination technique, a delay interval with fixed terminals is changed into the one with flexible terminals, which is called flexible terminal method (FTM). Second, based on the FTM, a novel Lyapunov-Krasovskii functional is constructed, in which the integral interval associated with delayed variables is not fixed. Thus, the FTM can achieve the same effect as that of delay-partitioning method, while their implementary ways are different...
July 19, 2016: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/27444730/intrinsic-network-connectivity-and-own-body-perception-in-gender-dysphoria
#16
Jamie D Feusner, Andreas Lidström, Teena D Moody, Cecilia Dhejne, Susan Y Bookheimer, Ivanka Savic
Gender dysphoria (GD) is characterized by incongruence between one's identity and gender assigned at birth. The biological mechanisms of GD are unclear. We investigated brain network connectivity patterns involved in own body perception in the context of self in GD. Twenty-seven female-to-male (FtM) individuals with GD, 27 male controls, and 27 female controls underwent resting state fMRI. We compared functional connections within intrinsic connectivity networks involved in self-referential processes and own body perception -default mode network (DMN) and salience network - and visual networks, using independent components analyses...
July 21, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27385543/body-composition-changes-in-an-endurance-athlete-using-two-different-training-strategies
#17
Peter Francis, William Mc Cormack, Aaron Caseley, June Copeman, Gareth Jones
Swimming, running and cycling are among the most popular and fastest growing sports in the world. Inherent in these sports is a desire to favourably alter body composition. Here we report a ~5.4kg and ~5.3kg fat tissue mass (FTM) loss in two separate interventions (12 - 16 weeks), in the same athlete, separated by 5 years. Whole body composition was assessed using dual x-ray absorptiometry (DXA). Dietary analysis for intervention 2 was completed using Mc Cance and Widdowson's composition of foods. In 2010, the male athlete (23 yrs, 85kg, 195cm, 18...
July 6, 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/27367048/phenotypic-characterization-and-genetic-dissection-of-growth-period-traits-in-soybean-glycine-max-using-association-mapping
#18
Zhangxiong Liu, Huihui Li, Xuhong Fan, Wen Huang, Jiyu Yang, Candong Li, Zixiang Wen, Yinghui Li, Rongxia Guan, Yong Guo, Ruzhen Chang, Dechun Wang, Shuming Wang, Li-Juan Qiu
The growth period traits are important traits that affect soybean yield. The insights into the genetic basis of growth period traits can provide theoretical basis for cultivated area division, rational distribution, and molecular breeding for soybean varieties. In this study, genome-wide association analysis (GWAS) was exploited to detect the quantitative trait loci (QTL) for number of days to flowering (ETF), number of days from flowering to maturity (FTM), and number of days to maturity (ETM) using 4032 single nucleotide polymorphism (SNP) markers with 146 cultivars mainly from Northeast China...
2016: PloS One
https://www.readbyqxmd.com/read/27255307/a-review-of-the-status-of-brain-structure-research-in-transsexualism
#19
Antonio Guillamon, Carme Junque, Esther Gómez-Gil
The present review focuses on the brain structure of male-to-female (MtF) and female-to-male (FtM) homosexual transsexuals before and after cross-sex hormone treatment as shown by in vivo neuroimaging techniques. Cortical thickness and diffusion tensor imaging studies suggest that the brain of MtFs presents complex mixtures of masculine, feminine, and demasculinized regions, while FtMs show feminine, masculine, and defeminized regions. Consequently, the specific brain phenotypes proposed for MtFs and FtMs differ from those of both heterosexual males and females...
October 2016: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/27236082/gender-transition-affects-neural-correlates-of-empathy-a-resting-state-functional-connectivity-study-with-ultra-high-field-7t-mr-imaging
#20
M Spies, A Hahn, G S Kranz, R Sladky, U Kaufmann, A Hummer, S Ganger, C Kraus, D Winkler, R Seiger, E Comasco, C Windischberger, S Kasper, R Lanzenberger
Sex-steroid hormones have repeatedly been shown to influence empathy, which is in turn reflected in resting state functional connectivity (rsFC). Cross-sex hormone treatment in transgender individuals provides the opportunity to examine changes to rsFC over gender transition. We aimed to investigate whether sex-steroid hormones influence rsFC patterns related to unique aspects of empathy, namely emotion recognition and description as well as emotional contagion. RsFC data was acquired with 7Tesla magnetic resonance imaging in 24 male-to-female (MtF) and 33 female-to-male (FtM) transgender individuals before treatment, in addition to 33 male- and 44 female controls...
September 2016: NeuroImage
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