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https://www.readbyqxmd.com/read/29307784/ablating-both-fabp1-and-scp2-scpx-tko-induces-hepatic-phospholipid-and-cholesterol-accumulation-in-high-fat-fed-mice
#1
Sherrelle Milligan, Gregory G Martin, Danilo Landrock, Avery L McIntosh, John T Mackie, Friedhelm Schroeder, Ann B Kier
Although singly ablating Fabp1 or Scp2/Scpx genes may exacerbate the impact of high fat diet (HFD) on whole body phenotype and non-alcoholic fatty liver disease (NAFLD), concomitant upregulation of the non-ablated gene, preference for ad libitum fed HFD, and sex differences complicate interpretation. Therefore, these issues were addressed in male and female mice ablated in both genes (Fabp1/Scp2/Scpx null or TKO) and pair-fed HFD. Wild-type (WT) males gained more body weight as fat tissue mass (FTM) and exhibited higher hepatic lipid accumulation than WT females...
January 4, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29238388/what-do-transgender-patients-teach-us-about-idiopathic-intracranial-hypertension
#2
Catherine Hornby, Susan P Mollan, James Mitchell, Keira Annie Markey, Andreas Yangou, Ben L C Wright, Michael W O'Reilly, Alexandra J Sinclair
Idiopathic intracranial hypertension (IIH), a condition of raised intracranial pressure, is characterised by headaches and visual disturbances. Its pathogenesis is currently unknown; however, dysregulation of androgens may be implicated. Here, the authors present a case of a 22-year-old patient undergoing female-to-male (FTM) gender reassignment who developed IIH shortly after commencing testosterone therapy. This interesting case presents the possibility of androgens having a pathogenic role in IIH.
2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29232019/thalamic-deep-brain-stimulation-for-essential-tremor-also-reduces-voice-tremor
#3
Bornali Kundu, Lauren Schrock, Tyler Davis, Paul A House
OBJECTIVE: Voice tremor is a common feature of essential tremor (ET) that is difficult to treat medically and significantly affects quality of life. Deep brain stimulation (DBS) of the ventral intermediate nucleus (Vim) of the thalamus is effective in improving contralateral distal limb tremor and has been shown in limited studies to affect voice tremor. Our objective was to retrospectively evaluate whether Vim-DBS used to treat patients with essential motor tremor also effectively treated underlying concurrent voice tremor and assess whether particular lead locations were favorable for treating vocal tremor...
December 12, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29184847/novel-biorelevant-dissolution-medium-as-a-prognostic-tool-for-polysaccharide-based-colon-targeted-drug-delivery-system
#4
Ankit Kumar Yadav, Manik Sadora, Sachin Kumar Singh, Monica Gulati, Peddi Maharshi, Abhinav Sharma, Bimlesh Kumar, Harish Rathee, Deepak Ghai, Adil Hussain Malik, Varun Garg, K Gowthamrajan
To overcome the limitations of the conventionally used methods for evaluation of orally administered colon-targeted delivery systems, a novel dissolution method using probiotics has been recently reported. In the present study, universal suitability of this medium composed of five different probiotics is established. Different delivery systems - mini tablets, liquisolid compacts, and microspheres coated with different polysaccharides - were prepared and subjected to sequential dissolution testing in medium with and without microbiota...
October 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/29178533/urethral-complications-after-transgender-phalloplasty-and-strategies-to-treat-them-and-minimize-their-occurrence
#5
REVIEW
Richard A Santucci
BACKGROUND: Radial forearm free flap phalloplasty (RFFP) is the current standard of care for most FTM gender confirmation surgeries. This procedure is associated with a rate of urethral stricture as high as 51%, which falls only to 23-35% even among the most experienced contemporary surgeons. While some modifications have been proposed to combat this high complication rate, it still remains a major source of lasting morbidity. METHODS: Literature review of RFFP literature...
November 27, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/29169588/changes-in-hormonal-and-metabolic-parameters-in-transgender-subjects-on-cross-sex-hormone-therapy-a-cohort-study
#6
Roberto Vita, Salvatore Settineri, Marco Liotta, Salvatore Benvenga, Francesco Trimarchi
OBJECTIVES: Gender identity disorder is defined as a strong and persistent cross-gender identification that is associated with a remarkable uneasiness of living in an incongruent gender (gender dysphoria). We performed a retrospective study on the hormonal and metabolic effects of cross-sex hormone therapy (CSHT) in a small cohort of transgender patients. STUDY DESIGN: Retrospective study. MEAN OUTCOME MEASURES: Hormonal and biochemical parameters at baseline (i...
January 2018: Maturitas
https://www.readbyqxmd.com/read/29157315/botulinum-toxin-type-a-injections-as-monotherapy-for-upper-limb-essential-tremor-using-kinematics
#7
Olivia Samotus, Niraj Kumar, Philippe Rizek, Mandar Jog
BACKGROUND: There is a significant need for a targeted therapy for essential tremor (ET), as medications have not been developed specifically for ET, and the ones prescribed are often not well-tolerated, so that many patients remain untreated. Recent work has shown that, unlike previous experience, kinematically guided individualized botulinum toxin type A (BoNT-A) injections provide benefit along with minimal weakness. Ours is the first long-term (96-week) safety and efficacy study of BoNT-A as monotherapy for ET using kinematically driven injection parameters...
November 21, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29145707/relationship-between-testosterone-in-serum-saliva-and-urine-during-treatment-with-intramuscular-testosterone-undecanoate-in-gender-dysphoria-and-male-hypogonadism
#8
Y Lood, E Aardal-Eriksson, C Webe, J Ahlner, B Ekman, J Wahlberg
Long-term testosterone replacement therapy is mainly monitored by trough levels of serum testosterone (S-T), while urinary testosterone (U-T) is used by forensic toxicology to evaluate testosterone doping. Testosterone in saliva (Sal-T) may provide additional information and simplify the sample collection. We aimed to investigate the relationships between testosterone measured in saliva, serum and urine during standard treatment with 1,000 mg testosterone undecanoate (TU) every 12th week during 1 year. This was an observational study...
November 16, 2017: Andrology
https://www.readbyqxmd.com/read/29130419/recapitulation-of-native-dermal-tissue-in-a-full-thickness-human-skin-model-using-human-collagens
#9
Arnout Mieremet, Marion Rietveld, Rianne van Dijk, Joke A Bouwstra, Abdoelwaheb El Ghalbzouri
OBJECTIVE: Full thickness skin models are comprised of a three dimensional dermal equivalent based on an animal derived collagen matrix that harbours fibroblasts and an epidermal equivalent formed by keratinocytes. The functionality of both equivalents is influenced by many factors, including extracellular matrix composition and resident cell type. Animal-derived collagens differ in amino acid composition and physico-chemical properties from human collagens. This composition could alter the functionality of the dermal equivalent and epidermal morphogenesis with the barrier formation in full thickness models (FTMs)...
November 12, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29098684/comparative-hindlimb-myology-of-foot-propelled-swimming-birds
#10
Glenna T Clifton, Jennifer A Carr, Andrew A Biewener
Several groups of birds have convergently evolved the ability to swim using their feet despite facing trade-offs with walking. However, swimming relative to terrestrial performance varies across these groups. Highly specialized divers, such as loons and grebes, excel at swimming underwater but struggle to stand on land, whereas species that primarily swim on the water surface, such as Mallards, retain the ability to move terrestrially. The identification of skeletal features associated with a swimming style and conserved across independent groups suggests that the hindlimb of foot-propelled swimming birds has adapted to suit the physical challenges of producing propulsive forces underwater...
November 3, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/29096982/fractal-fluctuations-in-spatiotemporal-variables-when-walking-on-a-self-paced-treadmill
#11
Jin-Seung Choi, Dong-Won Kang, Jeong-Woo Seo, Gye-Rae Tack
This study investigated the fractal dynamic properties of stride time (ST), stride length (SL) and stride speed (SS) during walking on a self-paced treadmill (STM) in which the belt speed is automatically controlled by the walking speed. Twelve healthy young subjects participated in the study. The subjects walked at their preferred walking speed under four conditions: STM, STM with a metronome (STM+met), fixed-speed (conventional) treadmill (FTM), and FTM with a metronome (FTM+met). To compare the fractal dynamics between conditions, the mean, variability, and fractal dynamics of ST, SL, and SS were compared...
October 25, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29071544/masculine-voices-predict-well-being-in-female-to-male-transgender-individuals
#12
Seth O Watt, Konstantin O Tskhay, Nicholas O Rule
Voices convey important social information about an individual's identity, including gender. This is especially relevant to transgender individuals, who cite voice alteration as a primary goal of the gender alignment process. Although the voice is a primary target of testosterone therapy among female-to-male (FTM) trans people, little research has explored the effects of such changes on their psychological well-being. Here, we investigated how FTMs' vocal gender related to their well-being. A total of 77 FTMs (M age = 25...
October 25, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/29040349/female-to-male-gender-affirming-top-surgery-a-single-surgeon-s-15-year-retrospective-review-and-treatment-algorithm
#13
Giancarlo McEvenue, Fang Zhou Xu, Runting Cai, Hugh McLean
Background: Mastectomy, referred to here as "Top Surgery," is an important surgical step for female-to-male (FTM) transgender patients. The goal is to excise breast tissue and create a masculine chest contour. Despite the rising demand for Top Surgery, debate still exists regarding how to select the most appropriate surgical technique to optimize aesthetic outcomes safely. Objectives: To determine the safety profile and aesthetic outcome of one surgeon's 15-year FTM Top Surgery experience...
July 24, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28994816/the-aortic-ring-co-culture-assay-a-convenient-tool-to-assess-the-angiogenic-potential-of-mesenchymal-stromal-cells-in-vitro
#14
Farwah Iqbal, Yarden S Gratch, Peter Szaraz, Clifford L Librach
Angiogenesis is a complex, highly regulated process responsible for providing and maintaining adequate tissue perfusion. Insufficient vasculature maintenance and pathological malformations can result in severe ischemic diseases, while overly abundant vascular development is associated with cancer and inflammatory disorders. A promising form of pro-angiogenic therapy is the use of angiogenic cell sources, which can provide regulatory factors as well as physical support for newly developing vasculature. Mesenchymal Stromal Cells (MSCs) are extensively investigated candidates for vascular regeneration due to their paracrine effects and their ability to detect and home to ischemic or inflamed tissues...
September 18, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28972119/loss-of-fatty-acid-binding-protein-1-alters-the-hepatic-endocannabinoid-system-response-to-a-high-fat-diet
#15
Gregory G Martin, Danilo Landrock, Sarah Chung, Lawrence J Dangott, Avery L McIntosh, John T Mackie, Ann B Kier, Friedhelm Schroeder
Upregulation of the hepatic endocannabinoid (EC) receptor [cannabinoid receptor-1 (CB1)] and arachidonoylethanolamide (AEA) is associated with nonalcoholic fatty liver disease (NAFLD). Male mice fed high-fat diet (HFD) ad libitum also exhibit NAFLD, increased hepatic AEA, and obesity. But, preference for HFD complicates interpretation and almost nothing is known about these effects in females. These issues were addressed by pair-feeding HFD. Similarly to ad libitum-fed HFD, pair-fed HFD also increased WT male and female mouse fat tissue mass (FTM), but preferentially at the expense of lean tissue mass...
November 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28966878/digitizing-tablet-and-fahn-tolosa-mar%C3%A3-n-ratings-of-archimedes-spirals-have-comparable-minimum-detectable-change-in-essential-tremor
#16
Rodger J Elble, Aaron Ellenbogen
BACKGROUND: Drawing Archimedes spirals is a popular and valid method of assessing action tremor in the upper limbs. We performed the first blinded comparison of Fahn-Tolosa-Marín (FTM) ratings and tablet measures of essential tremor to determine if a digitizing tablet is better than 0-4 ratings in detecting changes in essential tremor that exceed random variability in tremor amplitude. METHODS: The large and small spirals of FTM were drawn with each hand on two consecutive days by 14 men and four women (age 60±8...
2017: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/28964001/-is-sexual-identity-optional-a-study-of-the-genetics-of-transsexuality
#17
Rosa M Fernández García, Eduardo Pásaro Méndez
Transsexualism in the ICD-10 (International Classification of Diseases, Tenth Revision), Gender Dysphoria in adolescents and adults in the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition), is characterized by a marked incongruence between one's experienced gender and biological sex. The etiology is complex, but some hypotheses suggest that Gender Dysphoria (GD) arises from discrepant cerebral and biological sexual differentiation. Increasing evidence supports the idea of genetic vulnerability...
September 2017: Cuadernos de Bioética: Revista Oficial de la Asociación Española de Bioética y Ética Médica
https://www.readbyqxmd.com/read/28945852/sex-steroids-and-cardiovascular-outcomes-in-transgender-individuals-a-systematic-review-and-meta-analysis
#18
Spyridoula Maraka, Naykky Singh Ospina, Rene Rodriguez-Gutierrez, Caroline J Davidge-Pitts, Todd B Nippoldt, Larry J Prokop, M Hassan Murad
Background: Transgender individuals receive cross-sex hormonal therapy to induce desired secondary sexual characteristics despite limited data regarding its effects on cardiovascular health. Methods: A comprehensive search of several databases up to 7 April 2015 was conducted for studies evaluating the effect of sex steroid use on lipids, myocardial infarction, stroke, venous thromboembolism (VTE), and mortality in transgender individuals. Pairs of reviewers selected and appraised the studies...
November 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28945851/effect-of-sex-steroids-on-the-bone-health-of-transgender-individuals-a-systematic-review-and-meta-analysis
#19
Naykky Singh-Ospina, Spyridoula Maraka, Rene Rodriguez-Gutierrez, Caroline Davidge-Pitts, Todd B Nippoldt, Larry J Prokop, Mohammad Hassan Murad
Background: The impact of sex steroids on bone health in transgender individuals is unclear. Methods: A comprehensive search of several databases to 7 April 2015 was conducted for studies evaluating bone health in transgender individuals receiving sex steroids. Pairs of reviewers selected and appraised studies. A random effects model was used to pool weighted mean differences and 95% confidence intervals (CIs). Results: Thirteen studies evaluating 639 transgender individuals were identified [392 male-to-female (MTF), 247 female-to-male (FTM)]...
November 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28943352/genital-reconstruction-for-the-transgendered-individual
#20
REVIEW
Marta R Bizic, Borko Stojanovic, Miroslav L Djordjevic
INTRODUCTION: Gender dysphoria is defined as one's belief that his/her body does not reflect his/her true "inner" identification of physical sex and requires medical and/or surgical treatment that will alter his/her body to better reflect what he/she believes is his/her true gender. OBJECTIVE: The aim was to describe current surgical techniques available in genital reconstruction for female-to-male (FTM) and male-to-female (MTF) transgender patients. STUDY DESIGN: We reviewed recently published papers concerning the most common procedures in genital reconstruction in FTM transgenders and in MTF transgenders...
October 2017: Journal of Pediatric Urology
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