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Rene Seiger, Andreas Hahn, Allan Hummer, Georg S Kranz, Sebastian Ganger, Michael Woletz, Christoph Kraus, Ronald Sladky, Alexander Kautzky, Siegfried Kasper, Christian Windischberger, Rupert Lanzenberger
Sex-steroid hormones are primarily involved in sexual differentiation and development and are thought to underlie processes related to cognition and emotion. However, divergent results have been reported concerning the effects of hormone administration on brain structure including side effects like brain atrophy and dementia. Cross-sex hormone therapy in transgender subjects offers a unique model for studying the effects of sex hormones on the living human brain. In this study, 25 Female-to-Male (FtM) and 14 Male-to-Female (MtF) subjects underwent MRI examinations at baseline and after a period of at least 4-months of continuous cross-sex hormone administration...
October 5, 2016: Psychoneuroendocrinology
Francesco Gaetano Casino, Carlo Basile
BACKGROUND: The recent interest in incremental haemodialysis (HD) is hindered by the current prescription based on a fixed target model (FTM) for the total (dialytic + renal) equivalent continuous clearance (ECC). The latter is expressed either as standard Kt/V (stdKt/V), i.e. the pre-dialysis averaged concentration of urea-based ECC, or EKRc, i.e. the time averaged concentration-based ECC, corrected for volume (V) = 40 L. Accordingly, there are two different targets: stdKt/V = 2.3 volumes per week (v/wk) and EKRc = 13 mL/min/40 L...
October 14, 2016: Nephrology, Dialysis, Transplantation
Danny Gordon, Mario Prajna Pratama
This work sough to document how Indonesian trans* FTM persons experienced discrimination across the interlinked domains of social networks, religious and educational institutions, employment and the workplace and health/healthcare institutions. Objectives were 1) to map the discrimination experienced by trans* FTM individuals in Indonesia, and 2) to establish the specific priorities of the Indonesian trans* FTM community. In-depth interviews, focus-groups and participant observation was used involving 14 respondents...
October 5, 2016: Journal of Homosexuality
Clare Bellhouse, Sandra Walker, Christopher K Fairley, Lenka A Vodstrcil, Catriona S Bradshaw, Marcus Y Chen, Eric P F Chow
OBJECTIVE: Literature surrounding the healthcare needs of transgender individuals is limited in Australia. This study aimed to investigate the demographic characteristics, risk behaviours and HIV/STI positivity among male-to-female (MTF) and female-to-male (FTM) transgender individuals attending Melbourne Sexual Health Centre (MSHC), Australia, between 2011 and 2014. METHOD: A retrospective cohort analysis for 133 transgender individuals was conducted based on the first visit of individuals to MSHC during the study period...
September 29, 2016: Sexually Transmitted Infections
Agnes Masengu, Jennifer B Hanko, Alexander P Maxwell
PURPOSE: Increased arterial stiffness is a common finding in patients with end-stage renal disease. Following creation of an arteriovenous fistula (AVF), appropriate dilation of the feeding artery must occur to facilitate AVF maturation. Arterial stiffness may impair the arterial dilation required to facilitate AVF development and contribute to subsequent failure to mature (FTM). The aim of this pilot study was to investigate the association between measurements of central and peripheral arterial stiffness, and AVF FTM...
September 3, 2016: Journal of Vascular Access
Laura K Case, David Brang, Rosalynn Landazuri, Pavitra Viswanathan, Vilayanur S Ramachandran
While most people take identification with their body for granted, conditions such as phantom limb pain, alien hand syndrome, and xenomelia suggest that the feeling of bodily congruence is constructed and susceptible to alteration. Individuals with xenomelia typically experience one of their limbs as over-present and aversive, leading to a desire to amputate the limb. Similarly, many transgender individuals describe their untreated sexed body parts as incongruent and aversive, and many experience phantom body parts of the sex they identify with (Ramachandran, 2008)...
September 19, 2016: Archives of Sexual Behavior
Zhizhong Han, Zhenbao Liu, Junwei Han, Chi-Man Vong, Shuhui Bu, Xuelong Li
Extracting local features from 3D shapes is an important and challenging task that usually requires carefully designed 3D shape descriptors. However, these descriptors are hand-crafted and require intensive human intervention with prior knowledge. To tackle this issue, we propose a novel deep learning model, namely Circle Convolutional Restricted Boltzmann Machine (CCRBM), for unsupervised 3D local feature learning. CCRBM is specially designed to learn from raw 3D representations. It effectively overcomes obstacles such as irregular vertex topology, orientation ambiguity on the 3D surface, and rigid or slightly non-rigid transformation invariance in the hierarchical learning of 3D data that cannot be resolved by the existing deep learning models...
September 2, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
Jaclyn M White Hughto, Sari L Reisner
OBJECTIVES: To review evidence from prospective cohort studies of the relationship between hormone therapy and changes in psychological functioning and quality of life in transgender individuals accessing hormone therapy over time. DATA SOURCES: MEDLINE, PsycINFO, and PubMed were searched for relevant studies from inception to November 2014. Reference lists of included studies were hand searched. RESULTS: Three uncontrolled prospective cohort studies, enrolling 247 transgender adults (180 male-to-female [MTF], 67 female-to-male [FTM]) initiating hormone therapy for the treatment of gender identity disorder (prior diagnostic term for gender dysphoria), were identified...
January 2016: Transgend Health
Zhanshan Wang, Sanbo Ding, Qihe Shan, Huaguang Zhang
This brief is concerned with the stability criteria for recurrent neural networks with time-varying delay. First, based on convex combination technique, a delay interval with fixed terminals is changed into the one with flexible terminals, which is called flexible terminal method (FTM). Second, based on the FTM, a novel Lyapunov-Krasovskii functional is constructed, in which the integral interval associated with delayed variables is not fixed. Thus, the FTM can achieve the same effect as that of delay-partitioning method, while their implementary ways are different...
July 19, 2016: IEEE Transactions on Neural Networks and Learning Systems
Jamie D Feusner, Andreas Lidström, Teena D Moody, Cecilia Dhejne, Susan Y Bookheimer, Ivanka Savic
Gender dysphoria (GD) is characterized by incongruence between one's identity and gender assigned at birth. The biological mechanisms of GD are unclear. We investigated brain network connectivity patterns involved in own body perception in the context of self in GD. Twenty-seven female-to-male (FtM) individuals with GD, 27 male controls, and 27 female controls underwent resting state fMRI. We compared functional connections within intrinsic connectivity networks involved in self-referential processes and own body perception -default mode network (DMN) and salience network - and visual networks, using independent components analyses...
July 21, 2016: Brain Imaging and Behavior
Peter Francis, William Mc Cormack, Aaron Caseley, June Copeman, Gareth Jones
Swimming, running and cycling are among the most popular and fastest growing sports in the world. Inherent in these sports is a desire to favourably alter body composition. Here we report a ~5.4kg and ~5.3kg fat tissue mass (FTM) loss in two separate interventions (12 - 16 weeks), in the same athlete, separated by 5 years. Whole body composition was assessed using dual x-ray absorptiometry (DXA). Dietary analysis for intervention 2 was completed using Mc Cance and Widdowson's composition of foods. In 2010, the male athlete (23 yrs, 85kg, 195cm, 18...
July 6, 2016: Journal of Sports Medicine and Physical Fitness
Zhangxiong Liu, Huihui Li, Xuhong Fan, Wen Huang, Jiyu Yang, Candong Li, Zixiang Wen, Yinghui Li, Rongxia Guan, Yong Guo, Ruzhen Chang, Dechun Wang, Shuming Wang, Li-Juan Qiu
The growth period traits are important traits that affect soybean yield. The insights into the genetic basis of growth period traits can provide theoretical basis for cultivated area division, rational distribution, and molecular breeding for soybean varieties. In this study, genome-wide association analysis (GWAS) was exploited to detect the quantitative trait loci (QTL) for number of days to flowering (ETF), number of days from flowering to maturity (FTM), and number of days to maturity (ETM) using 4032 single nucleotide polymorphism (SNP) markers with 146 cultivars mainly from Northeast China...
2016: PloS One
Antonio Guillamon, Carme Junque, Esther Gómez-Gil
The present review focuses on the brain structure of male-to-female (MtF) and female-to-male (FtM) homosexual transsexuals before and after cross-sex hormone treatment as shown by in vivo neuroimaging techniques. Cortical thickness and diffusion tensor imaging studies suggest that the brain of MtFs presents complex mixtures of masculine, feminine, and demasculinized regions, while FtMs show feminine, masculine, and defeminized regions. Consequently, the specific brain phenotypes proposed for MtFs and FtMs differ from those of both heterosexual males and females...
October 2016: Archives of Sexual Behavior
M Spies, A Hahn, G S Kranz, R Sladky, U Kaufmann, A Hummer, S Ganger, C Kraus, D Winkler, R Seiger, E Comasco, C Windischberger, S Kasper, R Lanzenberger
Sex-steroid hormones have repeatedly been shown to influence empathy, which is in turn reflected in resting state functional connectivity (rsFC). Cross-sex hormone treatment in transgender individuals provides the opportunity to examine changes to rsFC over gender transition. We aimed to investigate whether sex-steroid hormones influence rsFC patterns related to unique aspects of empathy, namely emotion recognition and description as well as emotional contagion. RsFC data was acquired with 7Tesla magnetic resonance imaging in 24 male-to-female (MtF) and 33 female-to-male (FtM) transgender individuals before treatment, in addition to 33 male- and 44 female controls...
September 2016: NeuroImage
Anirban Majumder, Debmalya Sanyal
CONTEXT: Awareness of gender dysphoria (GD) and its treatment is increasing. There is paucity of scientific data from India regarding the therapeutic options being used for alleviating GD, which includes psychotherapy, hormone, and surgical treatments. AIM: To study the therapeutic options including psychotherapy, hormone, and surgical treatments used for alleviating GD. SETTINGS AND DESIGN: This is a retrospective study of treatment preferences and outcome in 18 female-to-male (FTM) transgender subjects who presented to the endocrine clinic...
May 2016: Indian Journal of Endocrinology and Metabolism
Giuseppe Lombardi, Luisa Bellu, Ardi Pambuku, Alessandro Della Puppa, Pasquale Fiduccia, Miriam Farina, Domenico D'Avella, Vittorina Zagonel
The optimal treatment of recurrent glioblastoma (GBM) in elderly patients is unclear. Fotemustine (FTM) is a third-generation nitrosourea showing efficacy in gliomas and it has been used with different schedules in adult patients. We performed, for the first time anywhere, a mono-institutional retrospective study to analyze the clinical outcome of an alternative fotemustine schedule in elderly patients with recurrent GBM. Retrospectively, we analyzed all GBM patients 65 years or older previously treated with the combination of radiation therapy and temozolomide (TMZ), receiving an alternative FTM schedule as second-line treatment at our Oncological Center from October 2011 to October 2014 with an ECOG PS ≤ 2...
July 2016: Journal of Neuro-oncology
Peter Szaraz, Matthew Librach, Leila Maghen, Farwah Iqbal, Tanya A Barretto, Shlomit Kenigsberg, Andrée Gauthier-Fisher, Clifford L Librach
Myocardial infarction (MI) causes an extensive loss of heart muscle cells and leads to congestive heart disease (CAD), the leading cause of mortality and morbidity worldwide. Mesenchymal stromal cell- (MSC-) based cell therapy is a promising option to replace invasive interventions. However the optimal cell type providing significant cardiac regeneration after MI is yet to be found. The aim of our study was to investigate the cardiomyogenic differentiation potential of first trimester human umbilical cord perivascular cells (FTM HUCPVCs), a novel, young source of immunoprivileged mesenchymal stromal cells...
2016: Stem Cells International
Olivia Samotus, Fariborz Rahimi, Jack Lee, Mandar Jog
OBJECTIVE: Effective treatment for functional disability caused by essential tremor is a significant unmet need faced by many clinicians today. Current literature regarding focal therapy by botulinum toxin type A (BoNT-A) injections uses fixed dosing regimens, which cannot be individualized, provides only limited functional benefit and unacceptable muscle weakness commonly occurs. This 38-week open label study, the longest to-date, demonstrates how kinematic technology addressed all these issues by guiding muscle selection...
2016: PloS One
Christopher J Salgado, Lydia A Fein, Jimmy Chim, Carlos A Medina, Stephanie Demaso, Christopher Gomez
Radial forearm free flap phalloplasty is the most commonly performed flap for neophallus construction in the female-to-male (FtM) transgender patient. Urological complications, however, can arise quite frequently and can prevent the patient from urinating in the standing position, an important postsurgical goal for many. Using mucosa to construct the fixed urethra and to prelaminate the penile urethra has been successful in reducing urologic complications, particularly strictures and fistulas. Until now, only buccal, vaginal, colonic, and bladder sites have been described as sources for these mucosal grafts...
2016: Case Reports in Urology
Cristina Maccalli, Diana Giannarelli, Filippo Capocefalo, Lorenzo Pilla, Ester Fonsatti, Anna Maria Di Giacomo, Giorgio Parmiani, Michele Maio
Clinical activity was observed in metastatic melanoma (MM) patients treated with ipilimumab (IPI) combined with fotemustine (FTM) in the phase II NIBIT-M1 study. Peripheral blood mononuclear cells (PBMCs) and serum were collected from MM patients at pre- and at weeks 12 and 24 post-treatment. A comprehensive phenotypic and functional immunomonitoring of circulating T cells, and the detection of soluble immunoregulatory molecules was carried out and correlated with clinical outcome. The frequency at baseline and along the treatment of circulating T central memory cells expressing activation/differentiation markers, such as CD3(+)CD4(+)CD45RO(+)BTLA(+), CD3(+)CD4(+)4-1BB or Th17 lymphocytes correlated with the clinical outcome of MM patients...
February 2016: Oncoimmunology
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