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https://www.readbyqxmd.com/read/28922166/clinical-tremor-severity-estimation-using-an-instrumented-eating-utensil
#1
Svjetlana Miocinovic, Ali H Shoeb, Sarah Wang, Erica A Byrd, Nicole C Swann, Anupam Pathak, Jill L Ostrem
BACKGROUND/OBJECTIVE: We demonstrate the feasibility of estimating clinical tremor scores using an eating utensil with motion-sensing and tremor-cancellation technology in thirteen patients with tremor. METHODS: Three experts scored hand tremor using the modified Fahn-Tolosa-Marin (FTM) scale. A linear model was trained to estimate tremor severity using the recorded motion signals. RESULTS: The average neurologist FTM score was 1.6±0.7 for PD and 2...
September 11, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28903444/early-tumour-shrinkage-as-a-survival-predictor-in-patients-with-recurrent-glioblastoma-treated-with-bevacizumab-in-the-avareg-randomized-phase-ii-study
#2
Alba A Brandes, Gaetano Finocchiaro, Vittorina Zagonel, Michele Reni, Alessandra Fabi, Claudia Caserta, Alicia Tosoni, Marica Eoli, Giuseppe Lombardi, Matteo Clavarezza, Alexandro Paccapelo, Stefania Bartolini, Luigi Cirillo, Raffaele Agati, Enrico Franceschi
BACKGROUND: Disease assessment for recurrent glioblastoma (GBM) represents a challenge, especially with the use of antiangiogenic agents. Moreover, validated neuroradiological predictors of outcome are lacking. Recently, the concept of early tumor shrinkage (ETS) has been developed to better assess the ability of treatments in determining a rapid and remarkable tumor response. The aim of the study was to evaluate the role of ETS in predicting survival of GBM patients treated with BEV...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28870147/electronic-cleansing-in-computed-tomography-colonography-using-at-layer-identification-with-integration-of-gradient-directional-second-derivative-and-material-fraction-model
#3
Krisorn Chunhapongpipat, Ratinan Boonklurb, Bundit Chaopathomkul, Sirod Sirisup, Rajalida Lipikorn
BACKGROUND: In computed tomography colonography images, electronic cleansing (EC) is applied to remove opacified residual materials, called fecal-tagging materials (FTM), using positive-contrast tagging agents and laxative to facilitate polyp detection. METHODS: The proposed EC, EC prop , integrates the gradient directional second derivative into material fraction model to preserve submerged soft tissue (ST) under FTM. Three-material fraction model is used to remove FTM and artifacts at air-tagging (AT) layers and T-junctions where air, ST, and FTM material meet simultaneously...
September 4, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28866472/second-harmonic-generation-microscopy-as-a-tool-for-the-early-detection-of-crystallization-in-spray-dried-dispersions
#4
Clara Correa-Soto, Niraj S Trasi, Paul D Schmitt, Yongchao Su, Zhen Liu, Elise Miller, Narayan Variankaval, Patrick J Marsac, Garth J Simpson, Lynne S Taylor
Various techniques have been used to detect crystallization in amorphous solid dispersions (ASD). However, most of these techniques do not enable the detection of very low levels of crystallinity (<1%). The aim of the current study was to compare the sensitivity of second harmonic generation (SHG) microscopy with powder X-ray diffraction (XRPD) in detecting the presence of crystals in low drug loading amorphous solid dispersions. Amorphous solid dispersions of the poorly water soluble compounds, flutamide (FTM, 15wt...
August 24, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28861548/varied-reports-of-adult-transgender-suicidality-synthesizing-and-describing-the-peer-reviewed-and-gray-literature
#5
REVIEW
Noah Adams, Maaya Hitomi, Cherie Moody
Purpose: This article reports on the findings of a meta-synthesis undertaken on published gray transgender suicidality literature, to determine the average rate of suicidal ideation and attempts in this population. Methods: Studies included in this synthesis were restricted to the 42 that reported on 5 or more Canadian or U.S. adult participants, as published between 1997 and February 2016 in either gray or peer-reviewed health literature. Results: Across these 42 studies an average of 55% of respondents ideated about and 29% attempted suicide in their lifetimes...
2017: Transgender Health
https://www.readbyqxmd.com/read/28857896/viral-hepatitis-screening-in-transgender-patients-undergoing-gender-identity-hormonal-therapy
#6
Neeraj Mangla, Rifat Mamun, Ilan S Weisberg
BACKGROUND AND AIM: Viral hepatitis is a global health issue and can lead to cirrhosis, liver failure, and hepatocellular carcinoma. Guidelines for viral hepatitis screening in the transgender population do not exist. Transgender patients may be at higher risk for contracting viral hepatitis due to socioeconomic and behavioral factors. The aim of this study was to measure the quality of screening, prevalence, and susceptibility of viral hepatitis, and to identify barriers to screening in transgender patients undergoing gender identity hormonal therapy...
August 29, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28829419/in-vitro-differentiation-of-human-mesenchymal-stem-cells-into-functional-cardiomyocyte-like-cells
#7
Peter Szaraz, Yarden S Gratch, Farwah Iqbal, Clifford L Librach
Myocardial infarction and the subsequent ischemic cascade result in the extensive loss of cardiomyocytes, leading to congestive heart failure, the leading cause of mortality worldwide. Mesenchymal stem cells (MSCs) are a promising option for cell-based therapies to replace current, invasive techniques. MSCs can differentiate into mesenchymal lineages, including cardiac cell types, but complete differentiation into functional cells has not yet been achieved. Previous methods of differentiation were based on pharmacological agents or growth factors...
August 9, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28828563/breast-cancer-screening-in-transgender-patients-findings-from-the-2014-brfss-survey
#8
Anand Narayan, Lizza Lebron-Zapata, Elizabeth Morris
PURPOSE: Transgender patients undergoing transitions often receive cross-sex hormonal therapies, placing them at uncertain risk for developing breast cancer. There is limited population-based information about the extent to which transgender patients undergo mammography screening. Our purpose was to determine the extent to which transgender patients undergo mammography screening using nationally representative survey data. METHODS: Transgender participants between ages 40-74 in the 2014 Behavioral Risk Factor Surveillance System survey were included...
August 21, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28819863/effects-of-testosterone-treatment-on-hypothalamic-neuroplasticity-in-female-to-male-transgender-individuals
#9
Georg S Kranz, Andreas Hahn, Ulrike Kaufmann, Martin Tik, Sebastian Ganger, René Seiger, Allan Hummer, Christian Windischberger, Siegfried Kasper, Rupert Lanzenberger
Diffusion-weighted imaging (DWI) is used to measure gray matter tissue density and white matter fiber organization/directionality. Recent studies show that DWI also allows for assessing neuroplastic adaptations in the human hypothalamus. To this end, we investigated a potential influence of testosterone replacement therapy on hypothalamic microstructure in female-to-male (FtM) transgender individuals. 25 FtMs were measured at baseline, 4 weeks, and 4 months past treatment start and compared to 25 female and male controls...
August 17, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28807010/angiogenic-potency-evaluation-of-cell-therapy-candidates-by-a-novel-application-of-the-in-vitro-aortic-ring-assay
#10
Farwah Iqbal, Peter Szaraz, Matthew Librach, Andrée Gauthier-Fisher, Clifford L Librach
BACKGROUND: Due to limitations of current angiogenesis assays, we aimed to develop a novel application of the rat aortic ring assay to assess the angiogenic potential of mesenchymal stromal cells (MSCs). First-trimester human umbilical cord-derived perivascular cells (FTM HUCPVCs) have multipotent characteristics and previously demonstrated angiogenic potential. We compared the effect of this young source of MSCs and adult bone marrow stromal cells (BMSCs) on ex vivo aortic endothelial network formation...
August 14, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28716082/efficacy-of-hormonal-and-mental-treatments-with-mmpi-in-ftm-individuals-cross-sectional-and-longitudinal-studies
#11
Hiroyuki Oda, Toshihiko Kinoshita
BACKGROUND: Cross-sex hormone treatment (CSHT) is an important option for gender dysphoria (GD) individuals to improve the quality of life. However, in Japan, sex reassignment surgery (SRS) and CSHT for GD had been discontinued until 1998 (over 30 years). After resumption, the number of GD individuals wishing treatment rapidly increased. On the other hand, the number of medical institutions available for evaluation was limited. For this reason, hormonal treatment has been administered to GD individuals requiring the prompt start of CSHT in the absence of mental health assessment by specialists...
July 17, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28657118/clinicopathologic-findings-in-female-to-male-gender-affirming-breast-surgery
#12
Ellen G East, Katherine M Gast, William M Kuzon, Emily Roberts, Lili Zhao, Julie M Jorns
AIMS: Gender dysphoria is a diagnosis wherein an individual identifies as the opposite gender. Management of patients seeking female-to-male (FTM) transition includes hormonal therapy and surgical intervention, including mastectomy. We aim to characterize the immunohistologic findings in resection specimens from FTM patients. METHODS AND RESULTS: We reviewed 68 cases (67 patients, 1 with re-excision) of FTM breast tissue resection by collecting clinical data, reviewing breast imaging and pathology reports (gross fibrous density, specimen weight and number of cassettes submitted), and reviewing pathology slides (number of tissue pieces submitted, number of terminal duct lobule units [TDLUs], and presence of histologic findings)...
June 28, 2017: Histopathology
https://www.readbyqxmd.com/read/28586370/long-term-tremor-therapy-for-parkinson-and-essential-tremor-with-sensor-guided-botulinum-toxin-type-a-injections
#13
Olivia Samotus, Jack Lee, Mandar Jog
OBJECTIVE: Current pharmacological agents used to treat Parkinson disease (PD) tremor and essential tremor (ET) provide suboptimal benefit and are commonly associated with significant adverse effects. Botulinum toxin type A (BoNT-A) has been shown to be effective for wrist tremor though functionally bothersome muscle weakness frequently occurs. This is the longest study to date demonstrating that BoNT-A therapy coupled with kinematic guidance can provide efficacious outcomes for upper limb tremor with minimized unwanted weakness...
2017: PloS One
https://www.readbyqxmd.com/read/28557560/a-retrospective-study-of-peroral-endoscopic-full-thickness-myotomy-in-patients-with-severe-achalasia
#14
Tianying Duan, Yuyong Tan, Junfeng Zhou, Liang Lv, Deliang Liu
OBJECTIVES: Selective circular myotomy (CM) is recommended in peroral endoscopic myotomy (POEM) for achalasia, but completeness of myotmoy is the prerequisite for excellent long-term results of conventional surgical myotomy. The aim of our study was to compare the efficacy and safety between peroral endoscopic full-thickness and simple CM for the treatment of severe achalasia. MATERIALS AND METHODS: A total of 123 severe achalasia patients who underwent POEM from August 2011 to May 2013 were included...
August 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28508877/an-overview-of-female-to-male-gender-confirming-surgery
#15
REVIEW
Shane D Morrison, Mang L Chen, Curtis N Crane
Gender dysphoria is estimated to occur in approximately 25 million people worldwide, and can have severe psychosocial sequelae. Medical and surgical gender transition can substantially improve quality-of-life outcomes for individuals with gender dysphoria. Individuals seeking to undergo female-to-male (FtM) transition have various surgical options available for gender confirmation, including facial and chest masculinization, body contouring, and genital surgery. The World Professional Association for Transgender Health guidelines should be met before the patient undergoes surgery, to ensure that gender-confirming surgery is appropriate and indicated...
August 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28473641/ladder-treadmill-a-method-to-assess-locomotion-in-cats-with-an-intact-or-lesioned-spinal-cord
#16
Manuel Escalona, Hugo Delivet-Mongrain, Aritra Kundu, Jean-Pierre Gossard, Serge Rossignol
After lesions of the CNS, locomotor abilities of animals (mainly cats) are often assessed on a simple flat treadmill (FTM), which imposes little demands on supraspinal structures as is the case when walking on targets. Therefore, the aims of the present work were as follows: (1) to develop a treadmill allowing the assessment of locomotion of intact cats required to place the paws on the rungs of a moving ladder treadmill (LTM); (2) to assess the capability of cats after a unilateral spinal hemisection at T10 to cope with such a demanding locomotor task; and (3) to regularly train cats for 6 weeks on the LTM to determine whether such regular training improves locomotor recovery on the FTM...
May 31, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28427164/early-tumour-shrinkage-as-a-survival-predictor-in-patients-with-recurrent-glioblastoma-treated-with-bevacizumab-in-the-avareg-randomized-phase-ii-study
#17
Alba A Brandes, Gaetano Finocchiaro, Vittorina Zagonel, Michele Reni, Alessandra Fabi, Claudia Caserta, Alicia Tosoni, Marica Eoli, Giuseppe Lombardi, Matteo Clavarezza, Alexandro Paccapelo, Stefania Bartolini, Luigi Cirillo, Raffaele Agati, Enrico Franceschi
BACKGROUND: Disease assessment for recurrent glioblastoma (GBM) represents a challenge, especially with the use of antiangiogenic agents. Moreover, validated neuroradiological predictors of outcome are lacking. Recently, the concept of early tumor shrinkage (ETS) has been developed to better assess the ability of treatments in determining a rapid and remarkable tumor response.The aim of the study was to evaluate the role of ETS in predicting survival of GBM patients treated with BEVMETHODS: We examined the radiological data of patients with recurrent GBM treated with bevacizumab (BEV) or fotemustine (FTM) in the randomized phase II AVAREG trial (EudraCT: 2011-001363-46)...
February 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28418342/transsexual-mastectomy-selection-of-appropriate-technique-according-to-breast-characteristics
#18
Hüsamettin Top, Serkan Balta
BACKGROUND: Subcutaneous mastectomy for female- to-male transsexuals is usually the first surgical pro- cedure in sexual reassignment. The main objective of subcutaneous mastectomy is to create an aesthetically pleasing male chest contour by removing all glandular tissue while minimizing chest wall scars. AIMS: In this paper, we present our experience with subcutaneous mastectomy performed in female-to- male transsexual patients. The authors recommend their point of view to aid in selecting the most suitable subcutaneous mastectomy technique depending on breast characteristics...
April 5, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28387629/is-staged-bilateral-thalamic-radiosurgery-an-option-for-otherwise-surgically-ineligible-patients-with-medically-refractory-bilateral-tremor
#19
Ajay Niranjan, Sudesh S Raju, Edward A Monaco, John C Flickinger, L Dade Lunsford
OBJECTIVE Unilateral Gamma Knife thalamotomy (GKT) is a well-established treatment for patients with medically refractory tremor who are not eligible for invasive procedures due to increased risk of compications. The purpose of this study was to evaluate whether staged bilateral GKT provides benefit with acceptable risk to patients suffering from disabling medically refractory bilateral tremor. METHODS Eleven patients underwent staged bilateral GKT during a 17-year period (1999-2016). Eight patients had essential tremor (ET), 2 had Parkinson's disease (PD)-related tremor, and 1 had multiple-sclerosis (MS)-related tremor...
April 7, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28382456/effect-of-fabp1-scp-2-scp-x-ablation-on-whole-body-and-hepatic-phenotype-of-phytol-fed-male-mice
#20
Danilo Landrock, Sherrelle Milligan, Gregory G Martin, Avery L McIntosh, Kerstin K Landrock, Friedhelm Schroeder, Ann B Kier
Liver fatty acid binding protein (Fabp1) and sterol carrier protein-2/sterol carrier protein-x (SCP-2/SCP-x) genes encode proteins that enhance hepatic uptake, cytosolic transport, and peroxisomal oxidation of toxic branched-chain fatty acids derived from dietary phytol. Since male wild-type (WT) mice express markedly higher levels of these proteins than females, the impact of ablating both genes (TKO) was examined in phytol-fed males. In WT males, high phytol diet alone had little impact on whole body weight and did not alter the proportion of lean tissue mass (LTM) versus fat tissue mass (FTM)...
May 2017: Lipids
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