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Vulvar lichen planus

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https://www.readbyqxmd.com/read/28764581/skin-diseases-of-the-vulva-inflammatory-erosive-ulcerating-and-apocrine-gland-diseases-zinc-and-vitamin-deficiency-vulvodynia-and-vestibulodynia
#1
Freja Lærke Sand, Simon Francis Thomsen
Chronic, inflammatory and ulcerating mucocutaneous diseases that can affect the vulvar area are reviewed: lichen sclerosus, lichen planus, plasma cell vulvitis, complex aphthosis, Behcet's disease, pyoderma gangrenosum, metastatic Crohn's disease, dyskeratotic skin diseases (Hailey-Hailey disease and Darier's disease), autoimmune bullous diseases (mucous membrane pemphigoid and pemphigus vulgaris) and hidradenitis suppurativa. Also, vulvodynia and vestibulodynia, zinc and vitamin B deficiency are described.
August 1, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28492056/lichenoid-vulvar-disease-a-review
#2
REVIEW
R Fruchter, L Melnick, M K Pomeranz
Vulvar dermatoses are common, potentially debilitating conditions that can be seen by a variety of medical specialists. Lichenoid vulvar diseases, namely lichen sclerosus (LS), lichen planus (LP), and lichen simplex chronicus (LSC), can all negatively impact patients' quality of life and LS and LP also have an association with squamous cell carcinoma. It is essential that dermatologists are familiar with the unique features of each of these conditions to ensure the appropriate management and follow up. Herein, we provide an update on the epidemiology, clinical presentation, histopathology, and treatment of patients with vulvar LS, LP, and LSC...
March 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28442799/study-of-pruritus-vulvae-in-geriatric-age-group-in-tertiary-hospital
#3
Jasleen Kaur, Jyotika Kalsy
BACKGROUND: According to the World Health Organization criteria, geriatric population is people above 60 years of age. In this phase of life, a woman has already gone through menopause and its associated emotional, physical, and hormonal changes. These changes are due to gradual loss of estrogen that comes with menopause which results in dramatic changes in the appearance of vulva and vagina. With age, skin of vulva becomes thin, loses elasticity, and moisture so that the patient starts feeling burning and itchy sensation...
January 2017: Indian Journal of Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28369011/comorbid-vulvar-lichen-planus-and-lichen-sclerosus
#4
Tania Day, Sarah Moore, Tanja Gizela Bohl, James Scurry
OBJECTIVES: The aims of the study are to assess the histopathologic characteristics of vulvar biopsies consistent with lichen planus (LP) in women with a previous or concurrent histopathologic diagnosis of vulvar lichen sclerosus (LS) and to describe the clinical features of comorbid LP and LS. MATERIALS AND METHODS: Patients were included if a diagnosis of LP was confirmed after review of the hematoxylin and eosin slides and the histopathology reporting LS noted a band of abnormal collagen...
March 31, 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28259230/vulvovaginal-issues-in-mature-women
#5
REVIEW
Mary L Marnach, Rochelle R Torgerson
Mature women often present with symptomatic vulvovaginal atrophy and vulvar dermatoses, causing noncoital pain, dyspareunia, and sexual changes. Diagnosis of these conditions can be challenging, and long-term management is required to decrease morbidity and enhance quality of life. Vaginal estrogen therapies remain safe and effective for treating symptomatic vulvovaginal atrophy. A vulvar biopsy is easy to perform and generally well tolerated when indicated for the diagnosis of lichen simplex chronicus, lichen sclerosus, and lichen planus...
March 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27490079/human-papillomavirus-induced-squamous-intraepithelial-lesions-in-vulvar-lichen-planus
#6
Sigrid Regauer, Barbara Eberz, Olaf Reich
OBJECTIVES: Approximately 50% of vulvar cancers arise after transforming infections with human papilloma virus (HPV) via the precursor squamous intraepithelial lesion (SIL). Lichen planus (LP)-associated vulvar cancers are typically HPV negative and arise via the precursor differentiated vulvar intraepithelial neoplasia (d-VIN). METHODS: An index case of vulvar high-grade squamous intraepithelial lesion (H-SIL) in an LP patient prompted this 12-year retrospective analysis about frequency of HPV-induced SIL in 785 biopsies of 584 patients with vulvar LP...
October 2016: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/27093036/can-routine-histopathology-distinguish-between-vulvar-cutaneous-candidosis-and-dermatophytosis
#7
Tania Day, Ailsa Borbolla Foster, Samuel Phillips, Ross Pagano, Delwyn Dyall-Smith, James Scurry, Suzanne M Garland
OBJECTIVES: This study aimed to determine if vulvar cutaneous candidosis and dermatophytosis can be distinguished by routine histopathology. MATERIALS AND METHODS: Twenty-four cases of periodic acid-Schiff-stained vulvar biopsies with a diagnosis of cutaneous mycosis were reviewed and histopathological characteristics on both periodic acid-Schiff and hematoxylin and eosin were recorded. Data were collected on age, clinical impression, microbiological results, and treatment, and all specimens underwent multiplex polymerase chain reaction analysis...
July 2016: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/26796658/distinguishing-erosive-lichen-planus-from-differentiated-vulvar-intraepithelial-neoplasia
#8
Tania Day, Nikola Bowden, Ken Jaaback, Geoff Otton, James Scurry
OBJECTIVE: Erosive lichen planus (LP) and differentiated vulvar intraepithelial neoplasia (dVIN) may display overlapping histopathologic features. MATERIALS AND METHODS: We searched the local pathology database for vulvar biopsies reported as dVIN or erosive vulvitis during 2011 to 2013 inclusive. After review of patient notes and slides, there were 5 cases with a clinical appearance and course consistent with erosive LP and histopathology showing epithelial regeneration...
April 2016: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/26650699/epithelial-vulvar-neoplasms-and-their-changing-classification
#9
REVIEW
Russell Ball, Katherine M Ball, Jason Reutter
In recent years, there have been many changes in the classification scheme for squamous lesions of the vulva; this is primarily due to the assimilation of new scientific information into the diagnostic terminology. For example, over the past 75 years we have realized that precancerous and cancerous lesions of the vulva may be induced by a variety of preconditions, which are typically divided into human papillomavirus (HPV) and non-HPV precursor lesions. The latter include several dermatoses, especially lichen sclerosus and lichen planus...
December 2015: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/26455062/vulvar-dermatoses-a-review-and-update
#10
REVIEW
Cassandra Simonetta, Erin K Burns, Mary A Guo
The purpose of this article is to review six important inflammatory dermatoses of the vulva and to update readers on the new advancements in treatment of these mucosal conditions. Psoriasis, lichen sclerosis, lichen simplex chronicus and lichen planus are common vulvar conditions that cause pruritis and/or pain. PIasma cell vulvitis and desquamative inflammatory vaginitis are rare and challenging to be recognized, which often remain undiagnosed.
July 2015: Missouri Medicine
https://www.readbyqxmd.com/read/26348378/surgical-management-of-vulvovaginal-agglutination-due-to-lichen-planus
#11
Pamela S Fairchild, Hope K Haefner
Lichen planus is a rare dermatological disorder that is often associated with painful and disfiguring vulvovaginal effects. At the University of Michigan Center for Vulvar Diseases, we see many women with vulvovaginal lichen planus each year, with marked scarring and vulvovaginal agglutination that precludes vaginal intercourse and causes difficulty with urination. Through our experience, we developed a protocol for the operative management and postoperative care for severe vulvovaginal agglutination. Our objective is to share this protocol with a wider audience so that providers who see patients with these devastating effects of lichen planus can benefit from our experience to better serve this patient population...
February 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26125955/inflammatory-vulvar-dermatoses
#12
REVIEW
Angela Guerrero, Aruna Venkatesan
Inflammatory vulvar dermatoses affect many women, but are likely underdiagnosed due to embarrassment and reluctance to visit a health care provider. Although itch and pain are common presenting symptoms, the physical examination can help distinguish between different disease entities. Because many women's health providers have minimal training in the categorization and management of dermatologic disease, definitive diagnosis and management can be difficult. Herein, strategies for diagnosing vulvar lichen sclerosus, lichen planus, contact dermatitis, lichen simplex chronicus, and psoriasis are discussed along with basic management of these diseases, which commonly involves decreasing inflammation through behavioral change, gentle skin care, topical corticosteroids, and systemic therapies...
September 2015: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26023590/total-acquired-vulval-synechia-an-unusual-presentation
#13
Anji Reddy Kallam
An unusual case of Acquired Total vulval synechia due to vulvar Lichen planus is reported in an 18-year-old girl, which is an extremely rare condition. It has a potential for producing extensive scarring and narrowing of introitus resulting in dyspareunia and rarely carcinoma of vulva. Successful surgical management of total vulvar synechiae in patient suffering from Lichen Planus is being reported.
April 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/25996085/vulvar-dermatoses-a-histopathologic-review-and-classification-of-183-cases
#14
May P Chan, Mary Jane Zimarowski
BACKGROUND: Vulvar dermatoses are often difficult to classify due to histopathologic overlap. We aimed to report our experience at a single institution. METHODS: A total of 183 non-neoplastic, non-infectious vulvar biopsies were reviewed. Associations between histopathologic features and specific diagnoses were analyzed by Chi-squared tests. RESULTS: Twenty-two biopsies (12.0%) showed two concurrent processes. A limited differential rather than a definitive diagnosis was rendered in 15 cases (8...
August 2015: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/25608255/lichen-sclerosus-and-lichen-planus-in-women-and-girls
#15
REVIEW
Bethanee J Schlosser, Ginat W Mirowski
Lichen planus and lichen sclerosus are common, chronic inflammatory vulvar dermatoses with significant morbidity. The course may wax and wane but disease often persists for decades. These autoimmune diseases have varied clinical presentations that extend beyond the genitalia. Management is best undertaken using a multidisciplinary approach and active patient involvement. The first-line treatment of both conditions is superpotent topical corticosteroids. Supportive measures and adjunct therapies can optimize patient outcomes...
March 2015: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/25475624/-vulvar-diseases
#16
M Peckruhn, P Elsner
Vulvar diseases might cause problems in the differential diagnosis, because the clinical presentation of inflammatory, infectious and neoplastic disorders may be quite similar. Itching and pain as well as dysuria and dyspareunia are the most common symptoms of vulvar diseases. Inflammatory dermatoses like atopic and contact dermatitis, lichen planus, lichen sclerosus and atrophic vulvitis account for the majority of cases in specialized clinics. Furthermore, neoplastic conditions such as vulvar carcinoma, vulvar intraepithelial neoplasia (VIN) and vulvar Paget's disease have to be considered...
January 2015: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/25132276/vulvar-dermatosis
#17
REVIEW
Micheline Moyal-Barracco, Jeanne Wendling
Vulvar dermatoses are inflammatory conditions responsible for chronic or recurrent itching and soreness. The lesions are either circumscribed to the vulva or associated with extragenital localizations which may help to assess the diagnosis. They should be differentiated from infectious or neoplastic diseases which may have clinical similarities. As opposed to the majority of all dermatoses that have a benign and regular course, lichen sclerosus or lichen planus could exceptionally foster the occurrence of an epithelial cancer precursor which may evolve to squamous cell carcinoma...
October 2014: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/24999271/vulvar-cancers-in-women-with-vulvar-lichen-planus-a-clinicopathological-study
#18
Sigrid Regauer, Olaf Reich, Barbara Eberz
BACKGROUND: Vulvar squamous cell carcinomas (SCCs) arising in association with vulvar lichen planus (LP) are poorly documented. OBJECTIVES: We sought to present clinicopathological features of 38 patients (median age 61 years, range 39-90 years) with LP-associated vulvar SCCs. METHODS: Evaluated were location of vulvar SCC and metastases at presentation, recurrences, survival, precursor lesions, presence of human papillomavirus DNA, p16ink4a, and p53 expression...
October 2014: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/24711996/pruritus-in-female-patients
#19
REVIEW
Julien Lambert
Pruritus is a frequent symptom in many dermatological diseases. In this review we want to focus on not only itch problems specific to women, namely, pruritic vulvodermatoses, but also the specific pruritic dermatoses of pregnancy. The specific characteristics of the vulva and the hormonal changes during the different age periods make these dermatoses very particular. It seems that vulvar diseases are still underdiagnosed and undertreated. Pruritic vulvar diseases have a huge impact on quality of life. The most common pruritic diseases will be discussed, such as atopic and contact dermatitis, psoriasis, lichen sclerosis, lichen planus, and infectious vulvaginitis...
2014: BioMed Research International
https://www.readbyqxmd.com/read/24530993/biodistribution-of-protoporphyrin-ix-in-female-genital-erosive-lichen-planus-after-topical-application-of-hexaminolevulinate
#20
RANDOMIZED CONTROLLED TRIAL
Anne Lise Ording Helgesen, Petter Gjersvik, Qian Peng, Vlada Vasovic, Are Hugo Pripp, Peter Jebsen, Tom Tanbo, Trond Warloe
Genital erosive lichen planus (GELP) is a chronic inflammatory disease, in women characterized by painful vulvar and vaginal erosions. To prepare for a clinical trial on photodynamic treatment (PDT), we applied hexyl 5-aminolevulinate hydrochloride (HAL) in clinically normal and affected mucosa in 12 women with GELP using two different doses (6.25 or 50mg/ml). Biopsies were taken after 30 min and 3h. The biodistribution of HAL, measured as photoactive protoporphyrin IX (PpIX), was studied using non-invasive superficial fluorescence measurements and microscopic fluorescence photometry...
June 2014: Photodiagnosis and Photodynamic Therapy
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