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Iron avidity

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https://www.readbyqxmd.com/read/27473221/pf4-bacteriophage-produced-by-pseudomonas-aeruginosa-inhibits-aspergillus-fumigatus-metabolism-via-iron-sequestration
#1
Jack C Penner, Jose A G Ferreira, Patrick R Secor, Johanna M Sweere, Maria K Birukova, Lydia-Marie Joubert, Janus A J Haagensen, Omar Garcia, Andrey V Malkovskiy, Gernot Kaber, Hasan Nazik, Robert Manasherob, Alfred M Spormann, Karl V Clemons, David A Stevens, Paul L Bollyky
Pseudomonas aeruginosa (Pa) and Aspergillus fumigatus (Af) are major human pathogens known to interact in a variety of disease settings, including airway infections in cystic fibrosis. We recently reported that clinical CF isolates of Pa inhibit the formation and growth of Af biofilms. Here, we report that the bacteriophage Pf4, produced by Pa, can inhibit the metabolic activity of Af biofilms. This phage-mediated inhibition was dose dependent, ablated by phage denaturation, and was more pronounced against preformed Af biofilm rather than biofilm formation...
September 2016: Microbiology
https://www.readbyqxmd.com/read/27296779/an-autoradiographic-evaluation-of-av-1451-tau-pet-in-dementia
#2
Val J Lowe, Geoffry Curran, Ping Fang, Amanda M Liesinger, Keith A Josephs, Joseph E Parisi, Kejal Kantarci, Bradley F Boeve, Mukesh K Pandey, Tyler Bruinsma, David S Knopman, David T Jones, Leonard Petrucelli, Casey N Cook, Neill R Graff-Radford, Dennis W Dickson, Ronald C Petersen, Clifford R Jack, Melissa E Murray
BACKGROUND: It is essential to determine the specificity of AV-1451 PET for tau in brain imaging by using pathological comparisons. We performed autoradiography in autopsy-confirmed Alzheimer disease and other neurodegenerative disorders to evaluate the specificity of AV-1451 binding for tau aggregates. METHODS: Tissue samples were selected that had a variety of dementia-related neuropathologies including Alzheimer disease, primary age-related tauopathy, tangle predominant dementia, non-Alzheimer disease tauopathies, frontotemporal dementia, parkinsonism, Lewy body disease and multiple system atrophy (n = 38)...
2016: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/27236131/iron-treatment-strategies-in-dialysis-dependent-ckd
#3
REVIEW
Richa Pandey, Reem Daloul, Daniel W Coyne
Iron deficiency is common in patients on chronic dialysis, and most require iron-replacement therapy. In addition to absolute iron deficiency, many patients have functional iron deficiency as shown by a suboptimal response to the use of erythropoietin-stimulating agents. Both absolute and functional iron-deficiency anemia have been shown to respond to intravenous (IV) iron replacement. Although parenteral iron is an efficacious method and superior to standard doses of oral iron in patients on hemodialysis, there are ongoing safety concerns about repeated exposure potentially enhancing infection risk and cardiovascular disease...
March 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27233771/enhanced-prion-detection-in-biological-samples-by-magnetic-particle-extraction-and-real-time-quaking-induced-conversion
#4
Nathaniel D Denkers, Davin M Henderson, Candace K Mathiason, Edward A Hoover
Prions have been demonstrated in body fluids and excreta using bioassay, but at levels too low for detection by conventional direct-detection assays. More rapid and sensitive detection of prions in these clinically accessible specimens would be valuable for diagnosis and investigations of transmission, environmental impact, and interventions. In addition to very low concentrations of prions, in vitro amplification assays are challenged by the presence of inhibitors in these complex sources. Here, we leverage the prion attribute of avid metal binding with the versatile power of real-time quaking-induced conversion (RT-QuIC) to enhance and simplify detection of chronic wasting-disease prions in biological samples...
August 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27184068/a-feasibility-study-showing-68-ga-citrate-pet-detects-prostate-cancer
#5
Spencer C Behr, Rahul Aggarwal, Youngho Seo, Carina M Aparici, Emily Chang, Kenneth T Gao, Dora H Tao, Eric J Small, Michael J Evans
PURPOSE: The management of advanced or recurrent prostate cancer is limited in part by the lack of effective imaging agents. Metabolic changes in prostate cancer have previously been exploited for imaging, culminating in the recent US FDA approval of [(11)C]choline for the detection of subclinical recurrent disease after definitive local therapy. Despite this milestone, production of [(11)C]choline requires an on-site cyclotron, limiting the scope of medical centers at which this scan can be offered...
May 16, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/26992127/the-modified-iron-avidity-index-a-promising-phenotypic-predictor-in-hfe-related-haemochromatosis
#6
Pauline L M Verhaegh, Wenke Moris, Ger H Koek, Cees Th B M van Deursen
OBJECTIVE: Phenotypes of the HFE-related haemochromatosis vary considerably, making it hard to predict the course of iron accumulation. The aim of this retrospective study was to determine if the Iron Avidity Index (IAI) is a good phenotypic predictor of the number of phlebotomies needed per year during maintenance treatment (NPDMT) in patients with homozygous p.C282Y hereditary haemochromatosis (HH). METHODS: Patients with HH homozygous for p.C282Y, on maintenance treatment for at least 1 year were included...
October 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/26844773/redox-cycling-metals-pedaling-their-roles-in-metabolism-and-their-use-in-the-development-of-novel-therapeutics
#7
REVIEW
Danuta S Kalinowski, Christian Stefani, Shinya Toyokuni, Tomas Ganz, Gregory J Anderson, Nathan V Subramaniam, Debbie Trinder, John K Olynyk, Anita Chua, Patric J Jansson, Sumit Sahni, Darius J R Lane, Angelica M Merlot, Zaklina Kovacevic, Michael L H Huang, C Soon Lee, Des R Richardson
Essential metals, such as iron and copper, play a critical role in a plethora of cellular processes including cell growth and proliferation. However, concomitantly, excess of these metal ions in the body can have deleterious effects due to their ability to generate cytotoxic reactive oxygen species (ROS). Thus, the human body has evolved a very well-orchestrated metabolic system that keeps tight control on the levels of these metal ions. Considering their very high proliferation rate, cancer cells require a high abundance of these metals compared to their normal counterparts...
April 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/26488074/modulatory-role-of-surface-coating-of-superparamagnetic-iron-oxide-nanoworms-in-complement-opsonization-and-leukocyte-uptake
#8
Swetha Inturi, Guankui Wang, Fangfang Chen, Nirmal K Banda, V Michael Holers, LinPing Wu, Seyed Moein Moghimi, Dmitri Simberg
Notwithstanding rapid advances of nanotechnology in diagnostic imaging and drug delivery, the engineered nanocarriers still exhibit substantial lack of hemocompatibility. Thus, when injected systemically, nanoparticles are avidly recognized by blood leukocytes and platelets, but the mechanisms of immune recognition are not well understood and strategies to mitigate these phenomena remain underexplored. Using superparamagnetic dextran iron oxide (SPIO) nanoworms (NWs) we demonstrate an efficient and predominantly complement-dependent uptake by mouse lymphocytes, neutrophils and monocytes from normal and tumor bearing mice in vitro...
November 24, 2015: ACS Nano
https://www.readbyqxmd.com/read/25874906/glucose-coated-superparamagnetic-iron-oxide-nanoparticles-prepared-by-metal-vapour-synthesis-are-electively-internalized-in-a-pancreatic-adenocarcinoma-cell-line-expressing-glut1-transporter
#9
Daniele Barbaro, Lorenzo Di Bari, Valentina Gandin, Claudio Evangelisti, Giovanni Vitulli, Eleonora Schiavi, Cristina Marzano, Anna M Ferretti, Piero Salvadori
Iron oxide nanoparticles (IONP) can have a variety of biomedical applications due to their visualization properties through Magnetic Resonance Imaging (MRI) and heating with radio frequency or alternating magnetic fields. In the oncological field, coating IONP with organic compounds to provide specific features and to achieve the ability of binding specific molecular targets appears to be very promising. To take advantage of the high avidity of tumor cells for glucose, we report the development of very small glucose-coated IONP (glc-IONP) by employing an innovative technique, Metal Vapor Synthesis (MVS)...
2015: PloS One
https://www.readbyqxmd.com/read/25872681/antibiotic-activity-of-iron-sequestering-polymers
#10
Nashwa El-Gendy, Jian Qian, Kate Eshelman, Mario Rivera, Cory Berkland
Increasing antibiotic resistance has compelled the development of novel antibiotics and adjuvant therapies that enhance the efficacy of existing antibiotics. Iron plays a critical role in bacterial infections, yet the use of iron chelators as adjuvant therapy with antibiotics has yielded highly variable outcomes. Multivalent polymeric materials offer an alternative approach to bind and sequester iron via high avidity interactions. Here, a biomimetic iron-sequestering polymer (PAI-DHBA) was synthesized by modifying side chains of cross-linked polyallylamine (cPAI) with 2,3-dihydroxybenzoic acid (DHBA)...
May 11, 2015: Biomacromolecules
https://www.readbyqxmd.com/read/25608173/high-liver-fdg-uptake-on-pet-ct-in-patient-with-lymphoma-diagnosed-with-hereditary-hemochromatosis
#11
Jose R Infante, Manuel Moreno, Juan I Rayo, Justo Serrano, Maria L Dominguez, Lucia Garcia
Hereditary hemochromatosis is an autosomal recessive disorder of iron metabolism resulting in toxic accumulation of iron in vital organs. We present a 64-year-old white man with non-Hodgkin lymphoma treated with high-dose chemotherapy and stem cell transplant that was subsequently diagnosed with hereditary hemochromatosis. F-FDG PET/CT was performed as routine follow-up and showed a pathological finding of homogeneous increased liver glucose metabolism. Increased FDG avidity in the liver suggested the presence of damage caused by hemochromatosis...
June 2015: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/25311854/seafood-intake-and-blood-cadmium-in-a-cohort-of-adult-avid-seafood-consumers
#12
Stanford Guan, Tia Palermo, Jaymie Meliker
Although the benefits of fish consumption are widely recognized, seafood may also be a source of exposure to heavy metals such as cadmium. Many types of seafood are rich in cadmium, but bioavailability and potential for toxicity after consumption is less clear. This study investigates the relationship between seafood intake and the level of cadmium (Cd) in the blood in a 252 person cohort of avid seafood consumers in the Long Island Study of Seafood Consumption (New York). Blood cadmium is an established biomarker of cadmium exposure, reflecting both recent and decade-long exposure...
January 2015: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/24810328/role-of-iscx-in-iron-sulfur-cluster-biogenesis-in-escherichia-coli
#13
Jin Hae Kim, Jameson R Bothe, Ronnie O Frederick, Johneisa C Holder, John L Markley
The Escherichia coli isc operon encodes key proteins involved in the biosynthesis of iron-sulfur (Fe-S) clusters. Whereas extensive studies of most ISC proteins have revealed their functional properties, the role of IscX (also dubbed YfhJ), a small acidic protein encoded by the last gene in the operon, has remained in question. Previous studies showed that IscX binds iron ions and interacts with the cysteine desulfurase (IscS) and the scaffold protein for cluster assembly (IscU), and it has been proposed that IscX functions either as an iron supplier or a regulator of Fe-S cluster biogenesis...
June 4, 2014: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/24716439/the-glycation-site-specificity-of-human-serum-transferrin-is-a-determinant-for-transferrin-s-functional-impairment-under-elevated-glycaemic-conditions
#14
André M N Silva, Paulo R H Sousa, João T S Coimbra, Natércia F Brás, Rui Vitorino, Pedro A Fernandes, Maria J Ramos, Maria Rangel, Pedro Domingues
The mechanisms involving iron toxicity in diabetes mellitus are not completely understood. However, the spontaneous reaction of reducing sugars with protein amino groups, known as glycation, has been shown to compromise the action of Tf (transferrin), the systemic iron transporter. In order to understand the structural alterations that impair its function, Tf was glycated in vitro and the modification sites were determined by MS. Iron binding to glycated Tf was assessed and a computational approach was conducted to study how glycation influences the iron-binding capacity of this protein...
July 1, 2014: Biochemical Journal
https://www.readbyqxmd.com/read/24467402/carbohydrate-appended-tumor-targeting-iron-iii-complexes-showing-photocytotoxicity-in-red-light
#15
Uttara Basu, Imran Khan, Akhtar Hussain, Bappaditya Gole, Paturu Kondaiah, Akhil R Chakravarty
Glucose-appended photocytotoxic iron(III) complexes of a tridentate Schiff base phenolate ligand [Fe(bpyag)(L)](NO3) (1-3), where bpyag is N,N-bis(2-pyridylmethyl)-2-aminoethyl-β-D-glucopyranoside and H2L is 3-(2-hydroxyphenylimino)-1-phenylbutan-1-one (H2phap) in 1, 3-(2-hydroxyphenylimino)-9-anthrylbutan-1-one (H2anap) in 2, and 3-(2-hydroxyphenylimino)-1-pyrenylbutan-1-one (H2pyap) in 3, were synthesized and characterized. The complex [Fe(dpma)(anap)](NO3) (4), having bis-(2-pyridylmethyl)benzylamine (dpma), in which the glucose moiety of bpyag is substituted by a phenyl group, was used as a control, and the complex [Fe(dpma)(anap)](PF6) (4a) was structurally characterized by X-ray crystallography...
February 17, 2014: Inorganic Chemistry
https://www.readbyqxmd.com/read/24443585/structure-and-biochemical-properties-of-the-alkene-producing-cytochrome-p450-oletje-cyp152l1-from-the-jeotgalicoccus-sp-8456-bacterium
#16
James Belcher, Kirsty J McLean, Sarah Matthews, Laura S Woodward, Karl Fisher, Stephen E J Rigby, David R Nelson, Donna Potts, Michael T Baynham, David A Parker, David Leys, Andrew W Munro
The production of hydrocarbons in nature has been documented for only a limited set of organisms, with many of the molecular components underpinning these processes only recently identified. There is an obvious scope for application of these catalysts and engineered variants thereof in the future production of biofuels. Here we present biochemical characterization and crystal structures of a cytochrome P450 fatty acid peroxygenase: the terminal alkene forming OleTJE (CYP152L1) from Jeotgalicoccus sp. 8456. OleTJE is stabilized at high ionic strength, but aggregation and precipitation of OleTJE in low salt buffer can be turned to advantage for purification, because resolubilized OleTJE is fully active and extensively dissociated from lipids...
March 7, 2014: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/24401789/update-on-intravenous-iron-choices
#17
REVIEW
Derek S Larson, Daniel W Coyne
PURPOSE OF REVIEW: Iron deficiency is a major factor in the prevalence and severity of anemia in patients with chronic kidney disease (CKD). We review the pathophysiology impairing normal intestinal iron absorption in CKD and compare the characteristics of newer intravenous (i.v.) iron agents to the longstanding i.v. iron products in the market. RECENT FINDINGS: The newer iron products, ferumoxytol, ferric carboxymaltose, and iron isomaltoside, more avidly bind iron, minimizing the release of labile iron during infusions, thus permitting large dose infusions...
March 2014: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/24036496/liver-x-receptor-activation-stimulates-iron-export-in-human-alternative-macrophages
#18
Gaël Bories, Sophie Colin, Jonathan Vanhoutte, Bruno Derudas, Corinne Copin, Mélanie Fanchon, Mehdi Daoudi, Loïc Belloy, Stephan Haulon, Christophe Zawadzki, Brigitte Jude, Bart Staels, Giulia Chinetti-Gbaguidi
RATIONALE: In atherosclerotic plaques, iron preferentially accumulates in macrophages where it can exert pro-oxidant activities. OBJECTIVE: The objective of this study was, first, to better characterize the iron distribution and metabolism in macrophage subpopulations in human atherosclerotic plaques and, second, to determine whether iron homeostasis is under the control of nuclear receptors, such as the liver X receptors (LXRs). METHODS AND RESULTS: Here we report that iron depots accumulate in human atherosclerotic plaque areas enriched in CD68 and mannose receptor (MR)-positive (CD68(+)MR(+)) alternative M2 macrophages...
November 8, 2013: Circulation Research
https://www.readbyqxmd.com/read/23890779/purged-versus-non-purged-peripheral-blood-stem-cell-transplantation-for-high-risk-neuroblastoma-cog-a3973-a-randomised-phase-3-trial
#19
RANDOMIZED CONTROLLED TRIAL
Susan G Kreissman, Robert C Seeger, Katherine K Matthay, Wendy B London, Richard Sposto, Stephan A Grupp, Daphne A Haas-Kogan, Michael P Laquaglia, Alice L Yu, Lisa Diller, Allen Buxton, Julie R Park, Susan L Cohn, John M Maris, C Patrick Reynolds, Judith G Villablanca
BACKGROUND: Myeloablative chemoradiotherapy and immunomagnetically purged autologous bone marrow transplantation has been shown to improve outcome for patients with high-risk neuroblastoma. Currently, peripheral blood stem cells (PBSC) are infused after myeloablative therapy, but the effect of purging is unknown. We did a randomised study of tumour-selective PBSC purging in stem-cell transplantation for patients with high-risk neuroblastoma. METHODS: Between March 16, 2001, and Feb 24, 2006, children and young adults (<30 years) with high-risk neuroblastoma were randomly assigned at diagnosis by a web-based system (in a 1:1 ratio) to receive either non-purged or immunomagnetically purged PBSC...
September 2013: Lancet Oncology
https://www.readbyqxmd.com/read/23440746/a-new-approach-to-studying-ion-uptake-by-actinomycetes
#20
Ismini Nakouti, Glyn Hobbs
A streptomycete that had the ability to avidly sequester iron via siderophores was previously isolated from environmental soil samples. The chelating agent expressed by this organism is confirmed by HPLC as desferrioxamine E. Although the traditional chromo azuerol sulphate (CAS) assay for detection of siderophores is based upon the chelation of iron we were interested to examine the relationship of these iron-capturing molecules with other ions. Consequently, a new approach was employed that enabled the assessment of the affinity of the siderophore moieties for other ions by adapting the CAS assay...
November 2013: Journal of Basic Microbiology
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