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Biomarker AND Stroke

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https://www.readbyqxmd.com/read/28812045/soluble-st2-predicts-outcome-and-hemorrhagic-transformation-after-acute-stroke
#1
Zoe Wolcott, Ayush Batra, Matthew B Bevers, Cristina Sastre, Jane Khoury, Matthew Sperling, Brett C Meyer, Kyle B Walsh, Opeolu Adeoye, Joseph P Broderick, W Taylor Kimberly
OBJECTIVE: ST2 is a member of the toll-like receptor superfamily that can alter inflammatory signaling of helper T-cells. We investigated whether soluble ST2 (sST2) could independently predict outcome and hemorrhagic transformation (HT) in the setting of stroke. METHODS: We measured sST2 in patients enrolled in the Specialized Program of Translational Research in Acute Stroke (SPOTRIAS) network biomarker study. 646 patients had plasma samples collected at the time of hospital admission and 210 patients had a second sample collected 48 h after stroke onset...
August 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28803840/development-and-validation-of-risk-equations-for-complications-of-type-2-diabetes-recode-using-individual-participant-data-from-randomised-trials
#2
Sanjay Basu, Jeremy B Sussman, Seth A Berkowitz, Rodney A Hayward, John S Yudkin
BACKGROUND: In view of substantial mis-estimation of risks of diabetes complications using existing equations, we sought to develop updated Risk Equations for Complications Of type 2 Diabetes (RECODe). METHODS: To develop and validate these risk equations, we used data from the Action to Control Cardiovascular Risk in Diabetes study (ACCORD, n=9635; 2001-09) and validated the equations for microvascular events using data from the Diabetes Prevention Program Outcomes Study (DPPOS, n=1018; 1996-2001), and for cardiovascular events using data from the Action for Health in Diabetes (Look AHEAD, n=4760; 2001-12)...
August 10, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28803534/moving-rehabilitation-research-forward-developing-consensus-statements-for-rehabilitation-and-recovery-research
#3
Julie Bernhardt, Karen Borschmann, Lara Boyd, S Thomas Carmichael, Dale Corbett, Steven C Cramer, Tammy Hoffmann, Gert Kwakkel, Sean Savitz, Gustavo Saposnik, Marion Walker, Nick Ward
Stroke recovery is the next frontier in stroke medicine. While growth in rehabilitation and recovery research is exponential, a number of barriers hamper our ability to rapidly progress the field. Standardized terminology is absent in both animal and human research, methods are poorly described, recovery biomarkers are not well defined, and we lack consistent timeframes or measures to examine outcomes. Agreed methods and conventions for developing, monitoring, evaluating and reporting interventions directed at improving recovery are lacking, and current approaches are often not underpinned by biology...
August 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28801883/prognostic-utility-of-fatty-acid-binding-protein-4-in-patients-with-type-2-diabetes-and-acute-ischemic-stroke
#4
Siou Li, Pengxiang Bi, Weina Zhao, Yifei Lian, Haifu Zhu, Dan Xu, Jiayuan Ding, Quankui Wang, Changhao Yin
The role of fatty acid-binding proteins (FABPs) in atherosclerosis has been investigated. The aim of this study was to verify the hypothesis that higher levels of serum fatty acid-binding protein 4 (FABP4) could be a prognostic factor in Chinese patients with type 2 diabetes (T2DM) and acute ischemic stroke (AIS). From September 2015 to August 2016, consecutive first-ever AIS patients combined with T2DM were included in this study. FABP4, NIH stroke scale (NIHSS), and conventional risk factors were evaluated to determine their value to predict functional outcomes within 3 months...
August 11, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28798136/adipose-tissue-metabolic-and-inflammatory-responses-to-stroke-are-altered-in-obese-mice
#5
Michael J Haley, Graham Mullard, Katherine A Hollywood, Garth J Cooper, Warwick B Dunn, Catherine B Lawrence
Obesity is an independent risk factor for stroke, though several clinical studies have reported that obesity improves stroke outcome. Obesity is hypothesised to aid recovery by protecting against post-stroke catabolism. We therefore assessed whether obese mice had an altered metabolic and inflammatory response to stroke. Obese ob/ob mice underwent 20 min middle cerebral artery occlusion and 24 h reperfusion. Lipid metabolism and expression of inflammatory cytokines were assessed in the plasma, liver and adipose tissue...
August 10, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28796845/improved-early-risk-stratification-of-patients-with-st-segment-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention-using-a-combination-of-serum-soluble-st2-and-nt-probnp
#6
Jongwook Yu, Pyung Chun Oh, Minsu Kim, Jeonggeun Moon, Yae Min Park, Kyounghoon Lee, Soon Yong Suh, Seung Hwan Han, Kyunghee Byun, Taehoon Ahn, Woong Chol Kang
BACKGROUND: Although soluble suppression of tumorigenicity 2 (sST2) in serum is known to be associated with ischemic heart disease and heart failure, data regarding its prognostic impact in ST-segment elevation myocardial infarction (STEMI) is limited. We evaluated the prognostic impacts of serum sST2 and other serum biomarkers in STEMI patients undergoing primary percutaneous coronary intervention (PCI). METHODS: Consecutive all 323 patients with STEMI that underwent primary PCI were enrolled...
2017: PloS One
https://www.readbyqxmd.com/read/28794427/neuroimaging-biomarkers-to-associate-obesity-and-negative-emotions
#7
Bo-Yong Park, Jisu Hong, Hyunjin Park
Obesity is a serious medical condition highly associated with health problems such as diabetes, hypertension, and stroke. Obesity is highly associated with negative emotional states, but the relationship between obesity and emotional states in terms of neuroimaging has not been fully explored. We obtained 196 emotion task functional magnetic resonance imaging (t-fMRI) from the Human Connectome Project database using a sampling scheme similar to a bootstrapping approach. Brain regions were specified by automated anatomical labeling atlas and the brain activity (z-statistics) of each brain region was correlated with body mass index (BMI) values...
August 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28794054/cardiovascular-event-prediction-by-machine-learning-the-multi-ethnic-study-of-atherosclerosis
#8
Bharath Ambale-Venkatesh, Xiaoying Yang, Colin O Wu, Kiang Liu, W G Hundley, Robyn L McClelland, Antoinette S Gomes, Aaron R Folsom, Steven Shea, Eliseo Guallar, David A Bluemke, João A Lima
Rationale: Machine learning may be useful to characterize cardiovascular risk, predict outcomes and identify biomarkers in population studies. Objective: To test the ability of random survival forests (RF), a machine learning technique, to predict six cardiovascular outcomes in comparison to standard cardiovascular risk scores. Methods and Results: We included participants from the Multi-Ethnic Study of Atherosclerosis (MESA). Baseline measurements were used to predict cardiovascular outcomes over 12 years of follow-up...
August 9, 2017: Circulation Research
https://www.readbyqxmd.com/read/28781090/fatty-acid-binding-protein-4-is-associated-with-stroke-risk-and-severity-in-patients-with-acute-ischemic-stroke
#9
Li Chang, Jianlong Zhang, Li Liu, Zhen Huang, Yingbo Han, Yanyan Zhu
OBJECTIVE: The role of fatty acid-binding proteins (FABPs) in atherosclerosis has been investigated. The aim of this study was to verify the hypothesis that higher levels of serum FABP4 could be a biomarker for stroke and associated with stroke severity in Chinese patients with ischemic stroke. METHODS: All consecutive patients with first-ever acute ischemic stroke from September 2015 to August 2016 were recruited to participate in the study. Serum FABP4 levels and routine tests were examined at admission...
July 19, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28775076/the-involvement-of-mirna-in-carotid-related-stroke
#10
REVIEW
Pierre Maitrias, Valérie Metzinger-Le Meuth, Joseph Nader, Thierry Reix, Thierry Caus, Laurent Metzinger
Cardiovascular disease is the leading cause of morbidity and mortality in developed countries. Stroke is associated with a marked disability burden and has a major economic impact; this is especially true for carotid artery stroke. Major advances in primary and secondary prevention during the last few decades have helped to tackle this public health problem. However, better knowledge of the physiopathology of stroke and its underlying genetic mechanisms is needed to improve diagnosis and therapy. miRNAs are an important, recently identified class of post-transcriptional regulators of gene expression and are known to be involved in cerebrovascular disease...
August 3, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28775014/brain-heart-interaction-cardiac-complications-after-stroke
#11
REVIEW
Zhili Chen, Poornima Venkat, Don Seyfried, Michael Chopp, Tao Yan, Jieli Chen
Neurocardiology is an emerging specialty that addresses the interaction between the brain and the heart, that is, the effects of cardiac injury on the brain and the effects of brain injury on the heart. This review article focuses on cardiac dysfunction in the setting of stroke such as ischemic stroke, brain hemorrhage, and subarachnoid hemorrhage. The majority of post-stroke deaths are attributed to neurological damage, and cardiovascular complications are the second leading cause of post-stroke mortality...
August 4, 2017: Circulation Research
https://www.readbyqxmd.com/read/28771541/the-frontline-of-immune-response-in-peripheral-blood
#12
Fuhai Song, Ying Qian, Xing Peng, Xiuhui Li, Peiqi Xing, Dongqing Ye, Hongxing Lei
Peripheral blood is an attractive source for the discovery of disease biomarkers. Gene expression profiling of whole blood or its components has been widely conducted for various diseases. However, due to population heterogeneity and the dynamic nature of gene expression, certain biomarkers discovered from blood transcriptome studies could not be replicated in independent studies. In the meantime, it's also important to know whether a reliable biomarker is shared by several diseases or specific to certain health conditions...
2017: PloS One
https://www.readbyqxmd.com/read/28771209/point-of-care-testing-in-acute-stroke-management-an-unmet-need-ripe-for-technological-harvest
#13
REVIEW
Dorin Harpaz, Evgeni Eltzov, Raymond C S Seet, Robert S Marks, Alfred I Y Tok
Stroke, the second highest leading cause of death, is caused by an abrupt interruption of blood to the brain. Supply of blood needs to be promptly restored to salvage brain tissues from irreversible neuronal death. Existing assessment of stroke patients is based largely on detailed clinical evaluation that is complemented by neuroimaging methods. However, emerging data point to the potential use of blood-derived biomarkers in aiding clinical decision-making especially in the diagnosis of ischemic stroke, triaging patients for acute reperfusion therapies, and in informing stroke mechanisms and prognosis...
August 3, 2017: Biosensors
https://www.readbyqxmd.com/read/28770211/prognostic-value-of-circulating-inflammatory-cells-in-patients-with-stable-and-acute-coronary-artery-disease
#14
REVIEW
John A L Meeuwsen, Marian Wesseling, Imo E Hoefer, Saskia C A de Jager
Atherosclerosis is a lipid driven chronic inflammatory disease underlying the majority of ischemic events such as myocardial infarction or stroke. Clinical management of ischemic events has improved considerably in the past decades. Accordingly, survival rates have increased. Nevertheless, 12% of patients die within 6 months after the initial event. To improve secondary prevention, appropriate risk prediction is key. However, up to date, there is no clinically available routine marker to identify patients at high risk for recurrent cardiovascular events...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28769870/altered-coupling-between-motion-related-activation-and-resting-state-brain-activity-in-the-ipsilesional-sensorimotor-cortex-after-cerebral-stroke
#15
Jianping Hu, Juan Du, Qiang Xu, Fang Yang, Fanyong Zeng, Xi-Jian Dai, Xiaoxue Liu, Guangming Lu, Zhiqiang Zhang
Functional connectivity maps using resting-state functional magnetic resonance imaging (rs-fMRI) can closely resemble task fMRI activation patterns, suggesting that resting-state brain activity may predict task-evoked activation or behavioral performance. However, this conclusion was mostly drawn upon a healthy population. It remains unclear whether the predictive ability of resting-state brain activity for task-evoked activation would change under different pathological conditions. This study investigated dynamic changes of coupling between patterns of resting-state functional connectivity (RSFC) and motion-related activation in different stages of cerebral stroke...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28769866/eye-control-deficits-coupled-to-hand-control-deficits-eye-hand-incoordination-in-chronic-cerebral-injury
#16
John-Ross Rizzo, James K Fung, Maryam Hosseini, Azadeh Shafieesabet, Edmond Ahdoot, Rosa M Pasculli, Janet C Rucker, Preeti Raghavan, Michael S Landy, Todd E Hudson
It is widely accepted that cerebral pathology can impair ocular motor and manual motor control. This is true in indolent and chronic processes, such as neurodegeneration and in acute processes such as stroke or those secondary to neurotrauma. More recently, it has been suggested that disruptions in these control systems are useful markers for prognostication and longitudinal monitoring. The utility of examining the relationship or the coupling between these systems has yet to be determined. We measured eye and hand-movement control in chronic, middle cerebral artery stroke, relative to healthy controls, in saccade-to-reach paradigms to assess eye-hand coordination...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28762762/gdf-15-and-trail-r2-are-powerful-predictors-of-long-term-mortality-in-patients-with-acute-myocardial-infarction
#17
Emma Skau, Egil Henriksen, Philippe Wagner, Pär Hedberg, Agneta Siegbahn, Jerzy Leppert
Background The Proximity Extension Assay proteomics chip provides a large-scale analysis of 92 biomarkers linked to cardiovascular disease or inflammation. We aimed to identify the biomarkers that best predicted long-term all-cause mortality in patients with acute myocardial infarction. Methods In this prospective cohort study, 92 biomarkers were analysed in 847 consecutive patients from the Västmanland Myocardial Infarction Study with a median follow-up of 6.9 years. Results The mean (± standard deviation) age of the patients was 70 (11...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28760218/growth-differentiation-factor-15-and-risk-of-major-bleeding-in-atrial-fibrillation-insights-from-the-randomized-evaluation-of-long-term-anticoagulation-therapy-re-ly-trial
#18
Ziad Hijazi, Jonas Oldgren, Ulrika Andersson, Stuart J Connolly, John W Eikelboom, Michael D Ezekowitz, Paul A Reilly, Salim Yusuf, Agneta Siegbahn, Lars Wallentin
OBJECTIVE: To evaluate and validate the prognostic value of growth-differentiation factor 15 (GDF-15) beyond clinical characteristics and other biomarkers concerning bleeding and stroke outcomes in patients with atrial fibrillation in the RE-LY trial. METHODS: GDF-15 was measured in samples collected at randomization in 8,474 patients with a median follow-up time of 1.9 years. Patients were stratified based on predefined GDF-15 cutoffs: group 1, <1,200 ng/L (the 90th percentile in healthy individuals); group 2, 1,200-1,800; and group 3, >1,800 ng/L (high-risk individuals)...
August 2017: American Heart Journal
https://www.readbyqxmd.com/read/28758524/transit-time-homogenization-in-ischemic-stroke-a-novel-biomarker-of-penumbral-microvascular-failure
#19
Thorbjørn S Engedal, Niels Hjort, Kristina D Hougaard, Claus Z Simonsen, Grethe Andersen, Irene Klærke Mikkelsen, Jens K Boldsen, Simon F Eskildsen, Mikkel B Hansen, Hugo Angleys, Sune N Jespersen, Salvador Pedraza, Tae H Cho, Joaquín Serena, Susanne Siemonsen, Götz Thomalla, Norbert Nighoghossian, Jens Fiehler, Kim Mouridsen, Leif Østergaard
Cerebral ischemia causes widespread capillary no-flow in animal studies. The extent of microvascular impairment in human stroke, however, is unclear. We examined how acute intra-voxel transit time characteristics and subsequent recanalization affect tissue outcome on follow-up MRI in a historic cohort of 126 acute ischemic stroke patients. Based on perfusion-weighted MRI data, we characterized voxel-wise transit times in terms of their mean transit time (MTT), standard deviation (capillary transit time heterogeneity - CTH), and the CTH:MTT ratio (relative transit time heterogeneity), which is expected to remain constant during changes in perfusion pressure in a microvasculature consisting of passive, compliant vessels...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28756014/caffeine-and-cardiovascular-health
#20
Duncan Turnbull, Joseph V Rodricks, Gregory F Mariano, Farah Chowdhury
This report evaluates the scientific literature on caffeine with respect to potential cardiovascular outcomes, specifically relative risks of total cardiovascular disease (CVD), coronary heart disease (CHD) and acute myocardial infarction (AMI), effects on arrhythmia, heart failure, sudden cardiac arrest, stroke, blood pressure, hypertension, and other biomarkers of effect, including heart rate, cerebral blood flow, cardiac output, plasma homocysteine levels, serum cholesterol levels, electrocardiogram (EKG) parameters, heart rate variability, endothelial/platelet function and plasma/urine catecholamine levels...
July 26, 2017: Regulatory Toxicology and Pharmacology: RTP
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