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Hepaticellular carcinoma

Xue-Wen Huang, Qi Zhao, Dao-Zhen Chen, Li-Shan Zhang
To explore the relationship between ROS level and mutations in D-Loop region of mtDNA, mutations in the D-Loop region of mtDNA and the ROS level in primary hepatocarcinoma tissues were studied. We amplified the D-Loop region of mtDNA of 20 hepatocarcinomas and their adjacent tissue by PCR and then sequencing. ROS in tissue was measured by flow cytometry. mtDNA mutations were detected in 40% (8 of 20) tumor samples. 53 point mutations were detected in eight tumour samples, including 2 insertions, 11 deletions and 40 point mutations...
January 2005: Yi Chuan, Hereditas
Si Hyun Bae, Eun Sun Jung, Young Min Park, Jeong Won Jang, Jong Young Choi, Se Hyun Cho, Seung Kew Yoon, Byung Min Ahn, Sang Bok Cha, Kyu Won Chung, Hee Sik Sun, Doo Ho Park, Byung Kee Kim, Dong Goo Kim
BACKGROUND/AIMS: E-cadherin is involved in intercellular binding and cellular polarity formation. beta-catenin plays a fundamental role in regulation of the E-cadherin cell adhesion complex. The abnormalities of the components of the complex may disrupt this adhesive function. We investigated the expression patterns of E-cadherin and beta-catenin to determine the clinical significance of these proteins in hepatocellular carcinoma. MATERIALS/METHODS: Thirty-six hepaticellular carcinoma tissues and adjacent non-tumor specimens were analyzed...
September 2002: Taehan Kan Hakhoe Chi, the Korean Journal of Hepatology
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