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https://www.readbyqxmd.com/read/28716046/blood-volume-monitored-regulation-of-ultrafiltration-to-decrease-the-dry-weight-in-fluid-overloaded-hemodialysis-patients-a-randomized-controlled-trial
#1
Marlies Antlanger, Peter Josten, Michael Kammer, Isabella Exner, Katharina Lorenz-Turnheim, Manfred Eigner, Gernot Paul, Renate Klauser-Braun, Gere Sunder-Plassmann, Marcus D Säemann, Manfred Hecking
BACKGROUND: Because chronic fluid volume overload is associated with higher mortality, we tested whether blood-volume monitored regulation of ultrafiltration and dialysate conductivity (UCR) and/or regulation of ultrafiltration and temperature (UTR) would facilitate dry weight reduction, in comparison to conventional dialysis (CONV). METHODS: We carried out a multicenter, 4-week, randomized controlled trial in hemodialysis patients ≥15% above normal extracellular fluid volume (ECV), per bioimpedance spectroscopy, who were randomized 1:1:1...
July 17, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28696993/special-communication-of-a-case-of-hypovolemic-associated-eah-lessons-learned-during-recovery
#2
Tamara Hew-Butler, Rus Hamilton, Bridget Hamilton, Zachary Colesa
Severe exercise-associated hyponatremia (EAH) is largely dilutional, whereas contributions of sodium loss remain equivocal. We present a case of EAH with encephalopathy involving an experienced male cyclist with no recollection of the event. We thereby conducted a retrospective analysis of biochemical trajectories during hospital recovery. The normalization of serum [Na], in context with changes in other variables, offered a 'reverse' perspective of the underlying pathophysiology. The following biochemical changes were temporally observed, with the return of normonatremia: 1) a decrease in serum potassium and calcium concentrations (absence of extracellular fluid dilution); 2) a decrease in total protein, blood urea nitrogen, hematocrit and hemoglobin (plasma volume expansion); and 3) an increase in mean platelet and red cell corpuscular volumes (cellular expansion after total body water and sodium deficits)...
July 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/28694730/topiramate-induced-metabolic-acidosis-and-kidney-stones-a-case-study
#3
Tomas Salek, Ivan Andel, Irena Kurfurstova
INTRODUCTION: The aim of this study is to present a case of 44 years old woman with topiramate induced metabolic acidosis and kidney stones. MATERIALS AND METHODS: The laboratory features of topiramate caused renal tubular acidosis in blood and urine during topiramate treatment, with correction of metabolic acidosis by potassium citrate, and after topiramate withdrawal are presented. Differential diagnosis of all possible causes of metabolic acidosis is discussed...
June 15, 2017: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/28678485/an-ursolic-acid-derived-small-molecule-triggers-cancer-cell-death-through-hyperstimulation-of-macropinocytosis
#4
Lin Sun, Bin Li, Xiaohui Su, Ge Chen, Yaqin Li, Linqian Yu, Li Li, Wanguo Wei
Macropinocytosis is a transient endocytosis that internalizes extracellular fluid and particles into vacuoles. Recent studies suggest that hyperstimulation of macropinocytosis can induce a novel nonapoptotic cell death, methuosis. In this report, we describe the identification of an ursolic acid derived small molecule (compound 17), which induces cancer cell death through hyperstimulation of macropinocytosis. 17 causes the accumulation of vacuoles derived from macropinosomes based on transmission electron microscopy, time-lapse microscopy, and labeling with extracellular fluid phase tracers...
July 19, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28675633/increased-urine-production-due-to-leg-fluid-displacement-reduces-hours-of-undisturbed-sleep
#5
Keisuke Kiba, Akihide Hirayama, Motokiyo Yoshikawa, Yutaka Yamamoto, Kazumasa Torimoto, Nobutaka Shimizu, Nobumichi Tanaka, Kiyohide Fujimoto, Hirotsugu Uemura
OBJECTIVE: To investigate whether or not the leg fluid displacement observed when moving from the standing to recumbent position at bedtime reduces the hours of undisturbed sleep (HUS). METHODS: Men aged 50 years or older who were hospitalized for urological diseases were investigated. Body water evaluation was performed three times with a bioelectric impedance method: (i) 17:00, (ii) 30 min after (short-term), and (iii) waking up (long-term). A frequency volume chart was used to evaluate the status of nocturnal urine production, and the factors affecting HUS were investigated...
July 3, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28663722/bacoside-a-induces-tumor-cell-death-in-human-glioblastoma-cell-lines-through-catastrophic-macropinocytosis
#6
Sebastian John, K C Sivakumar, Rashmi Mishra
Glioblastoma multiforme (GBM) is a highly aggressive type of brain tumor with an extremely poor prognosis. Recent evidences have shown that the "biomechanical imbalances" induced in GBM patient-derived glioblastoma cells (GC) and in vivo via the administration of synthetic small molecules, may effectively inhibit disease progression and prolong survival of GBM animal models. This novel concept associated with de novo anti-GBM drug development has however suffered obstacles in adequate clinical utility due to the appearance of unrelated toxicity in the prolonged therapeutic windows...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28650604/serum-adiponectin-levels-in-adolescents-and-young-adults-with-growth-hormone-deficiency
#7
(no author information available yet)
INTRODUCTION: Adiponectin (APN) is adipose tissue-derived hormone influencing energy metabolism. Growth hormone deficiency (GHD) may contribute to the development of disturbances in the hormonal function of adipose tissue (AT), and many disorders observed in untreated patients with GHD coincides with these contributed to low serum APN levels. OBJECTIVES: The assessment of serum adiponectin levels in adolescents and young adults with severe or partial GHD and analysis of relationships between serum APN and GH/IGF-1 axis function impairment as well as cardiometabolic risk factors...
May 26, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28641538/glt-1-upregulation-as-a-potential-therapeutic-target-for-ischemic-brain-injury
#8
Yu-Yan Hu, Li Li, Xiao-Hui Xian, Min Zhang, Xiao-Cai Sun, Shu-Qin Li, Xin Cui, Jie Qi, Wen-Bin Li
Glutamate is the primary excitatory neurotransmitter in the mammalian central nervous system, which plays an important role in many aspects of normal brain function such as neural development, motor functions, learning and memory etc. However, excessive accumulation of glutamate in the extracellular fluid will induce excitotoxicity which is considered to be a major mechanism of cell death in brain ischemia. There is no enzyme to decompose the glutamate in extracellular fluid, so extracellular glutamate homeostasis within the central nervous system is mainly regulated by the uptake activity of excitatory amino acid transporters...
June 22, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28629357/xuefuzhuyu-decoction-protected-cardiomyocytes-against-hypoxia-reoxygenation-injury-by-inhibiting-autophagy
#9
Xiaowen Shi, Haiyan Zhu, Yuanyuan Zhang, Mingmei Zhou, Danli Tang, Huamin Zhang
BACKGROUND: XuefuZhuyu decoction (XFZY) is a well-known traditional Chinese herbal medicine for the treatment of various cardiovascular diseases, such as unstable angina pectoris and myocardial ischemia-reperfusion injury. However, the mechanism by which XFZY contributes to the amelioration of cardiac injury remains unclear. METHODS: H9C2 cells were cultured under the hypoxic condition for 10 h and reoxygenated for 2 h. In the presence of various concentrations of XFZY for 12 h, the cell viability was measured by MTT assay...
June 19, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28623159/epigenetic-biomarkers-and-cardiovascular-disease-circulating-micrornas
#10
David de Gonzalo-Calvo, Eduardo Iglesias-Gutiérrez, Vicenta Llorente-Cortés
MicroRNAs (miRNAs) are a class of small noncoding RNA (20-25 nucleotides) involved in gene regulation. In recent years, miRNAs have emerged as a key epigenetic mechanism in the development and physiology of the cardiovascular system. These molecular species regulate basic functions in virtually all cell types, and are therefore directly associated with the pathophysiology of a large number of cardiovascular diseases. Since their relatively recent discovery in extracellular fluids, miRNAs have been studied as potential biomarkers of disease...
June 13, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28617649/correlation-between-the-severity-of-subcutaneous-echo-free-space-and-the-amount-of-extracellular-fluid-determined-by-bioelectrical-impedance-analysis-of-leg-edema
#11
Kotaro Suehiro, Noriyasu Morikage, Osamu Yamashita, Takasuke Harada, Makoto Samura, Yuriko Takeuchi, Takahiro Mizoguchi, Kaori Nakamura, Kimikazu Hamano
BACKGROUND: Both subcutaneous echo-free space (SEFS) observed by ultrasonography and the ratio of intracellular fluid resistance to extracellular fluid resistance (Ri/Re) calculated from bioelectrical impedance analysis (BIA) represent extracellular edema status in the extremities. We tried to correlate these parameters. METHODS AND RESULTS: In 70 legs with venous edema (VE) and 68 legs with lymphedema (LE), subcutaneous tissue ultrasonography to determine SEFS severity (range, 0-2) and BIA to calculate Ri/Re were performed...
June 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28617545/fluid-status-of-patients-during-the-early-stages-of-continuous-ambulatory-peritoneal-dialysis
#12
L Wang, W Yu, T Wang
OBJECTIVE: The purpose of this paper is to investigate the fluid status of patients in the early stages of continuous ambulatory peritoneal dialysis (CAPD). PATIENTS AND METHODS: A total of 36 patients (13 males and 23 females), hospitalized in the Nephrology CAPD Center, Peking University Third Hospital, and undergoing intubation and CAPD treatment, were recruited in this study. By utilize a bioelectrical impedance analyzer, changes in extracellular fluid and intracellular fluid within the patients' cells, and overall fluid changes were monitored throughout six months following CAPD treatment...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28615486/acid-base-physiology-neurobiology-and-behaviour-in-relation-to-co2-induced-ocean-acidification
#13
REVIEW
Martin Tresguerres, Trevor J Hamilton
Experimental exposure to ocean and freshwater acidification affects the behaviour of multiple aquatic organisms in laboratory tests. One proposed cause involves an imbalance in plasma chloride and bicarbonate ion concentrations as a result of acid-base regulation, causing the reversal of ionic fluxes through GABAA receptors, which leads to altered neuronal function. This model is exclusively based on differential effects of the GABAA receptor antagonist gabazine on control animals and those exposed to elevated CO2 However, direct measurements of actual chloride and bicarbonate concentrations in neurons and their extracellular fluids and of GABAA receptor properties in aquatic organisms are largely lacking...
June 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28611439/raman-micro-spectroscopy-as-a-viable-tool-to-monitor-and-estimate-the-ionic-transport-in-epithelial-cells
#14
Leonardo Puppulin, Giuseppe Pezzotti, Hongxin Sun, Shigekuni Hosogi, Takashi Nakahari, Toshio Inui, Yasuaki Kumamoto, Hideo Tanaka, Yoshinori Marunaka
The typical response to the lowering of plasma Na(+) concentration and blood pressure in our body involves the release of aldosterone from the adrenal glands, which triggers the reabsorption of sodium in the kidney. Although the effects of aldosterone on this physiological mechanism were extensively studied in the past decades, there are still some aspects to be fully elucidated. In the present study, we propose for the first time a new approach based on Raman spectroscopy to monitor the ionic activity in aldosterone-treated A6 renal epithelial cells...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28597995/k-responsive-block-copolymer-micelles-for-targeted-intracellular-drug-delivery
#15
Shan Yan, Lin-Yan Wan, Xiao-Jie Ju, Jiang-Feng Wu, Lei Zhang, Ming Li, Zhuang Liu, Wei Wang, Rui Xie, Liang-Yin Chu
In this work, a novel type of block copolymer micelles with K(+) -responsive characteristics for targeted intracellular drug delivery is developed. The proposed smart micelles are prepared by self-assembly of poly(ethylene glycol)-b-poly(N-isopropylacry-lamide-co-benzo-18-crown-6-acrylamide) (PEG-b-P(NIPAM-co-B18C6Am)) block copolymers. Prednisolone acetate (PA) is successfully loaded into the micelles as the model drug, with loading content of 4.7 wt%. The PA-loaded micelles display a significantly boosted drug release in simulated intracellular fluid with a high K(+) concentration of 150 × 10(-3) m, as compared with that in simulated extracellular fluid...
June 9, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28595555/microdialysis-assessed-adipose-tissue-metabolism-in-critically-ill-patients
#16
Ioannis Ilias, Nikitas Nikitas, Maria Theodorakopoulou, Ioanna Dimopoulou
BACKGROUND: Microdialysis is a minimally invasive technique that allows direct in situ and in vivo sampling, studies and manipulations of the interstitial/extracellular fluid/space. It has been shown to be of use mainly in acute brain injury/neurocritical care. METHODS: Microdialysis has been used to study obesity, diabetes mellitus, inflammation and pharmacokinetics at the adipose tissue level. In critically ill patients (and particularly in those with sepsis or septic shock), within days to weeks, adipose tissue shows profound alterations; under such conditions the implementation of microdialysis can provide researchers with interesting findings...
June 8, 2017: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/28586692/functional-innovations-and-the-conquest-of%C3%A2-the%C3%A2-oceans-by-acanthomorph-fishes
#17
REVIEW
Peter C Wainwright, Sarah J Longo
The world's oceans are home to many fantastic creatures, including about 16,000 species of actinopterygian, or ray-finned, fishes. Notably, 85% of marine fish species come from a single actinopterygian subgroup, the acanthomorph or spiny-rayed fishes. Here, we review eight functional innovations found in marine acanthomorphs that have been instrumental in the adaptive radiation of this group in the marine realm. Jaw protrusion substantially enhances the suction feeding mechanism found in all fish. Fin spines serve as a major deterrent to predators and enhance the locomotor function of fins...
June 5, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28586021/construction-and-characterization-of-a-transmembrane-eukaryotic-expression-vector-based-on-the-membrane-domain-structure-of-tnf-%C3%AE
#18
Fa Wang, Liang Zeng, Yue-Li Wang, Shi-Quan Cui, Liang Hu, Jun-Ming Zheng, Di-Nan Huang, Gan Hou
The aim of the present study was to construct a fast-acting, eukaryotic expression vector in eukaryotic cells based on transmembrane-tumor necrosis factor‑α (TM‑TNF‑α) structure. Two types of recombinant eukaryotic expression vectors were constructed, pcDNA3.1-TM-enterokinase-TNF‑α and pcDNA3.1‑TM‑Factor Xa‑TNF‑α, according to the TNF‑α transmembrane segments. Following the generation of these vectors, mouse embryonic 3T3 fibroblasts were transfected and reverse transcription‑polymerase chain reaction and western blotting analyses were used to analyze mTNF‑α mRNA and protein expression levels, respectively, in total cellular protein extracts and extracellular fluid...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28582610/protein-corona-impact-of-lymph-versus-blood-in-a-complex-in-vitro-environment
#19
Debora Bonvin, Ulrich Aschauer, Duncan T L Alexander, Diego Chiappe, Marc Moniatte, Heinrich Hofmann, Marijana Mionić Ebersold
In biological environments, the surface of nanoparticles (NPs) are modified by protein corona (PC) that determines their biological behavior. Unfortunately, in vitro tests still give different PC than in vivo tests causing in vitro-in vivo discrepancy; hence, in vitro studies are not indicative for the NPs' behavior in vivo. Here is demonstrated that PC in vitro is strongly influenced by the type of extracellular fluid (ECF), blood or lymph, by their high and low flow conditions and transitions between ECFs, and a combination of these parameters...
June 5, 2017: Small
https://www.readbyqxmd.com/read/28581677/interplay-of-volume-blood-pressure-organ-ischemia-residual-renal-function-and-diet-certainties-and-uncertainties-with-dialytic-management
#20
REVIEW
Ercan Ok, Nathan W Levin, Gulay Asci, Charles Chazot, Huseyin Toz, Mehmet Ozkahya
Extracellular fluid volume overload and its inevitable consequence, hypertension, increases cardiovascular mortality in the long term by leading to left ventricular hypertrophy, heart failure, and ischemic heart disease in dialysis patients. Unlike antihypertensive medications, a strict volume control strategy provides optimal blood pressure control without need for antihypertensive drugs. However, utilization of this strategy has remained limited because of several factors, including the absence of a gold standard method to assess volume status, difficulties in reducing extracellular fluid volume, and safety concerns associated with reduction of extracellular volume...
June 5, 2017: Seminars in Dialysis
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