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https://www.readbyqxmd.com/read/29913392/evaluation-of-ultrasound-guided-erector-spinae-plane-block-for-postoperative-analgesia-in-laparoscopic-cholecystectomy-a-prospective-randomized-controlled-clinical-trial
#1
Serkan Tulgar, Mahmut Sertan Kapakli, Ozgur Senturk, Onur Selvi, Talat Ercan Serifsoy, Zeliha Ozer
STUDY OBJECTIVE: Laparoscopic cholecystectomy (LC) is a commonly performed minimally invasive procedure that has led to a decrease in procedure-related mortality and morbidity. However, LC requires analgesia that blocks both visceral and somatic nerve fibers. In this study, we evaluated the effectiveness of Erector Spinae Plane Block (ESPB) for postoperative analgesia management in LC. DESIGN: Single-blinded, prospective, randomized, efficiency study. SETTING: Tertiary university hospital, postoperative recovery room & ward...
June 15, 2018: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/29913186/blockade-of-t-type-calcium-channels-by-6-prenylnaringenin-a-hop-component-alleviates-neuropathic-and-visceral-pain-in-mice
#2
Fumiko Sekiguchi, Tomoyo Fujita, Takahiro Deguchi, Sakura Yamaoka, Ken Tomochika, Maho Tsubota, Sumire Ono, Yamato Horaguchi, Maki Ichii, Mio Ichikawa, Yumiko Ueno, Nene Koike, Tadatoshi Tanino, Huy Du Nguyen, Takuya Okada, Hiroyuki Nishikawa, Shigeru Yoshida, Tsuyako Ohkubo, Naoki Toyooka, Kazuya Murata, Hideaki Matsuda, Atsufumi Kawabata
Since Cav 3.2 T-type Ca2+ channels (T-channels) expressed in the primary afferents and CNS contribute to intractable pain, we explored T-channel-blocking components in distinct herbal extracts using a whole-cell patch-clamp technique in HEK293 cells stably expressing Cav 3.2 or Cav 3.1, and purified and identified sophoraflavanone G (SG) as an active compound from SOPHORAE RADIX (SR). Interestingly, hop-derived SG analogues, (2S)-6-prenylnaringenin (6-PNG) and (2S)-8-PNG, but not naringenin, also blocked T-channels; IC50 (μM) of SG, (2S)-6-PNG and (2S)-8-PNG was 0...
June 15, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29911636/differential-analgesic-effects-of-subanesthetic-concentrations-of-lidocaine-on-spontaneous-and-evoked-pain-in-human-painful-neuroma-a-randomized-double-blind-study
#3
Adriana Miclescu, Martin Schmelz, Torsten Gordh
Background Both peripheral nerve injury and neuroma pain are the result of changes in sodium channel expression. Lidocaine selectively inhibits the spontaneous ectopic activity by binding to sodium channels. Subanesthetics concentrations of lidocaine are able to produce a differential block of the ectopic discharges, but not propagation of impulses, suppressing differentially the associated neuropathic pain symptoms. The aim of this study was to investigate the differences between the analgesic effects of lidocaine 0...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911581/real-time-ultrasound-guided-infraorbital-nerve-block-to-treat-trigeminal-neuralgia-using-a-high-concentration-of-tetracaine-dissolved-in-bupivacaine
#4
Kenichi Takechi, Amane Konishi, Kotaro Kikuchi, Shiho Fujioka, Tomomi Fujii, Toshihiro Yorozuya, Koh Kuzume, Takumi Nagaro
Background Trigeminal neuralgia is a neuropathic disorder characterized by episodes of intense pain in the face. Drug therapy is the first choice of treatment. However, in cases where drug therapy are contraindicated due to side effects, patients can get pain relief from lengthy neurosurgical procedures. Alternatively, a peripheral trigeminal nerve block can be easily performed in an outpatient setting. Therefore it is a useful treatment option for the acute paroxysmal period of TN in patients who cannot use drug therapy...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911579/ultrasound-guided-high-concentration-tetracaine-peripheral-nerve-block-effective-and-safe-relief-while-awaiting-more-permanent-intervention-for-tic-douloureux
#5
Axel Sauter, Harald Breivik
No abstract text is available yet for this article.
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911573/managing-post-thoracotomy-pain-epidural-or-systemic-analgesia-and-extended-care-a-randomized-study-with-an-as-usual-control-group
#6
Elina Tiippana, Kaisa Nelskylä, Eija Nilsson, Eero Sihvo, Matti Kataja, Eija Kalso
Background and aims Thoracotomies can cause severe pain, which persists in 21-67% of patients. We investigated whether NSAID + intravenous patient-controlled analgesia (IV-PCA) with morphine is an efficacious alternative to thoracic epidural analgesia (TEA). We also wanted to find out whether an extended controlled pain management protocol within a clinical study can decrease the incidence of persistent post-thoracotomy pain. Methods Thirty thoracotomy patients were randomized into 3 intervention groups with 10 patients in each...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911292/examining-the-association-of-body-mass-index-and-the-depth-of-epidural-space-radiation-dose-exposure-and-fluoroscopic-screening-time-during-transforaminal-nerve-block-injection-a-retrospective-cohort-study
#7
Adam S Galbraith, Emma Wallace, Aiden Devitt
OBJECTIVE: The primary objective of this study was to examine the association between body mass index (BMI) and the depth of tissue overlying the epidural space. Secondary objectives examined the association between BMI and (1) radiation dose exposure and (2) fluoroscopic screening time during transforaminal nerve block (TFNB) injections. METHODOLOGY: This is a retrospective cohort study including patients aged ≥ 16 years who underwent unilateral single-level TFNB in a single centre over a 28-month period, by a single spinal orthopaedic surgeon...
June 17, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29910770/motor-nerve-conduction-block-predicting-outcome-of-guillain-barre-syndrome
#8
Jingwen Niu, Mingsheng Liu, Qing Sun, Yi Li, Shuang Wu, Qingyun Ding, Yuzhou Guan, Liying Cui
Introduction: Motor nerve conduction blocks (CBs) could be detected in both acute inflammatory demyelinating polyradiculoneuropathy (AIDP) and acute motor axonal neuropathy (AMAN). We aimed to identify the correlation between CBs and functional outcome in the two subtypes of GBS. Methods: Motor nerve conduction studies were performed in 17 patients with AIDP and 23 with AMAN. All patients were treated with intravenous immunoglobulin, and their disabilities were evaluated with Hughes functional grading scale before treatment, 1 month and 6 months after onset...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29909125/effectiveness-of-using-low-rate-fluoroscopy-to-reduce-an-examiner-s-radiation-dose-during-lumbar-nerve-root-block
#9
Kentaro Yamane, Nobuo Kai, Tetsuro Mazaki, Tadashi Miyamoto, Tomohiro Matsushita
BACKGROUND: Long-term exposure to radiation can lead to gene mutations and increase the risk of cancer. Low rate fluoroscopy has the potential to reduce the radiation exposure for both the examiner and the patient during various fluoroscopic procedures. The purpose of this study was to evaluate the impact of low rate fluoroscopy on reducing an examiner's radiation dose during nerve root block. METHODS: A total of 101 lumbar nerve root block examinations were performed at our institute during a 6-month period...
June 13, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29908716/ultrasonographical-identification-of-the-superficial-circumflex-iliac-artery-as-a-landmark-for-location-of-the-femoral-nerve-in-dogs
#10
Fernando L Garcia-Pereira, Daniel Boruta, Sharon Tenenbaum, Vaidehi Paranjape
OBJECTIVE: To investigate the utility of identifying the superficial circumflex iliac artery (SCIA) via ultrasound as an anatomical landmark for ultrasound-guided femoral nerve block. STUDY DESIGN: Observational study. ANIMALS: A group of six canine cadavers weighing >20 kg. METHODS: Pelvic limbs from six canine cadavers were examined to study the relationship between the SCIA and the femoral nerve. Ultrasonographic imaging of the SCIA in each limb was obtained with the transducer placed transversely in the medial aspect of the pelvic limb at the inguinal area...
April 13, 2018: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29905631/ultrasound-guided-selective-versus-conventional-block-of-the-medial-brachial-cutaneous-and-the-intercostobrachial-nerves-a-randomized-clinical-trial
#11
Philippe Magazzeni, Denis Jochum, Gabriella Iohom, Gérard Mekler, Eliane Albuisson, Hervé Bouaziz
BACKGROUND AND OBJECTIVES: For superficial surgery of anteromedial and posteromedial surfaces of the upper arm, the medial brachial cutaneous nerve (MBCN) and the intercostobrachial nerve (ICBN) must be selectively blocked, in addition to an axillary brachial plexus block. We compared efficacy of ultrasound-guided (USG) versus conventional block of the MBCN and the ICBN. METHODS: Eighty-four patients, undergoing upper limb surgery, were randomized to receive either USG (n = 42) or conventional (n = 42) block of the MBCN and the ICBN with 1% mepivacaine...
June 13, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29905630/ultrasound-guided-percutaneous-peripheral-nerve-stimulation-neuromodulation-of-the-sciatic-nerve-for-postoperative-analgesia-following-ambulatory-foot-surgery-a-proof-of-concept-study
#12
Brian M Ilfeld, Rodney A Gabriel, Engy T Said, Amanda M Monahan, Jacklynn F Sztain, Wendy B Abramson, Bahareh Khatibi, John J Finneran, Pia T Jaeger, Alexandra K Schwartz, Sonya S Ahmed
BACKGROUND AND OBJECTIVES: Percutaneous peripheral nerve stimulation (PNS) is an analgesic modality involving the insertion of a lead through an introducing needle followed by the delivery of electric current. This modality has been reported to treat chronic pain as well as postoperative pain the day following knee surgery. However, it remains unknown if this analgesic technique may be used in ambulatory subjects following foot procedures beginning within the recovery room immediately following surgery, and with only short series of patients reported to date, the only available data are derived from strictly observational studies...
June 13, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29905605/polyglycolic-acid-felt-for-prevention-of-frey-syndrome-after-parotidectomy
#13
Tetsushi Aizawa, Masahiro Kuwabara, Satoshi Kubo, Shimpo Aoki, Ryuichi Azuma, Tomoharu Kiyosawa
BACKGROUND: Frey syndrome is one of the important complications of parotid surgery. Placing a barrier between the parotid gland and the skin flap is considered to be effective for preventing this syndrome by blocking misdirected regeneration of nerve fibers. Neoveil is nonwoven polyglycolic acid (PGA) felt that is used as absorbable reinforcing material. The present study evaluated the effectiveness of this PGA felt as a barrier for preventing Frey syndrome. METHODS: A total of 19 patients who underwent superficial parotidectomy from 2012 to 2017 were retrospectively reviewed...
June 13, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29903459/single-injection-adductor-canal-block-with-multiple-adjuvants-provides-equivalent-analgesia-when-compared-with-continuous-adductor-canal-blockade-for-primary-total-knee-arthroplasty-a-double-blinded-randomized-controlled-equivalency-trial
#14
James D Turner, Sean W Dobson, Daryl S Henshaw, Christopher J Edwards, Robert S Weller, Jon W Reynolds, Gregory B Russell, Jonathan D Jaffe
BACKGROUND: Peripheral nerve blockade is used to provide analgesia for patients undergoing total knee arthroplasty. This study compared a single-injection adductor canal block (SACB) with adjuvants to continuous adductor canal blockade (CACB). The hypothesis was that the 2 groups would have equivalent analgesia at 30 hours after neural blockade. METHODS: This was a double-blinded, randomized, controlled, equivalency trial. Sixty patients were randomized to either the SACB group (20 mL of 0...
May 24, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29901585/abdominal-peripheral-nerve-block-as-the-only-anesthetic-technique-for-totally-extraperitoneal-endoscopic-inguinal-hernia-repair-two-case-reports
#15
Woojin Kwon, Seunguk Bang, Hyojung Soh, Won Jun Jeong, Sang Chul Lee, Byung Jo Choi
RATIONALE: Laparoscopic totally extraperitoneal (TEP) inguinal hernia repair is a rapidly evolving, minimally invasive treatment modality for inguinal hernia. Compared with open hernia repair, this method requires a smaller incision, has cosmetic advantages, and facilitates rapid recovery and early return to daily activities because of less postoperative pain. Because general anesthesia is essential for TEP hernia repair, it cannot be performed on patients who have an increased risk of developing complications when placed under general anesthesia...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29897635/iridotomy-to-slow-progression-of-visual-field-loss-in-angle-closure-glaucoma
#16
REVIEW
Jimmy T Le, Benjamin Rouse, Gus Gazzard
BACKGROUND: Primary angle-closure glaucoma is a type of glaucoma associated with a physically obstructed anterior chamber angle. Obstruction of the anterior chamber angle blocks drainage of fluids (aqueous humor) within the eye and may raise intraocular pressure (IOP). Elevated IOP is associated with glaucomatous optic nerve damage and visual field loss. Laser peripheral iridotomy (often just called 'iridotomy') is a procedure to eliminate pupillary block by allowing aqueous humor to pass directly from the posterior to anterior chamber through use of a laser to create a hole in the iris...
June 13, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29894352/supraclavicular-brachial-plexus-neurolysis-for-a-malignant-peripheral-nerve-sheath-tumor-a-case-report
#17
Christopher Weiyang Liu, David Flamer
The perineural administration of alcohol or phenol results in protein denaturation and, consequently, neurolysis. This can produce long-lasting analgesia, with a duration of 3-6 months. Although neurolytic blocks for the brachial plexus have been described in multiple review articles and textbooks, they are rarely performed. As such, little is known about the efficacy and adverse effect profile of this commonly described treatment. In this article, we report the outcomes of a patient who underwent a left brachial plexus neurolytic block for the management of upper limb pain arising from a malignant peripheral nerve sheath tumor...
June 11, 2018: A&A practice
https://www.readbyqxmd.com/read/29894344/peripheral-nerve-block-provides-effective-analgesia-for-a-patient-with-peripheral-nerve-hyperexcitability-syndrome-isaacs-syndrome-case-report
#18
Akinori Asai, Eisuke Kako, Tatsuya Hasegawa, Kazuya Sobue
Isaacs syndrome is a rare peripheral nerve hyperexcitability syndrome. The painful discharges in Isaacs syndrome are abolished by the blockade of the neuromuscular junction but not by peripheral nerve blocks (PNB). However, the efficacy of PNB for intraoperative and postoperative analgesia among those with Isaacs syndrome is unknown. A 41-year-old woman with Isaacs syndrome underwent open reduction and internal fixation of radius fractures. Ultrasound-guided bilateral axillary brachial plexus blocks were performed, followed by general anesthesia...
June 11, 2018: A&A practice
https://www.readbyqxmd.com/read/29889698/perineural-low-dose-dexamethasone-prolongs-interscalene-block-analgesia-with-bupivacaine-compared-with-systemic-dexamethasone-a-randomized-trial
#19
Richard L Kahn, Jennifer Cheng, Yuliya Gadulov, Kara G Fields, Jacques T YaDeau, Lawrence V Gulotta
BACKGROUND AND OBJECTIVES: Perineural dexamethasone and intravenous (IV) dexamethasone have been shown to prolong peripheral nerve block duration. The effects of perineural and IV dexamethasone have only been compared at doses of 4 mg or greater. This triple-blind, randomized trial examined the effect of 1 mg IV versus perineural dexamethasone on interscalene block (ISB) analgesia duration. METHODS: Patients undergoing ambulatory shoulder arthroscopy received an ultrasound-guided ISB with 15 mL bupivacaine 0...
June 8, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29889119/targeting-toll-like-receptor-4-tlr4-emerging-therapeutic-target-for-persistent-pain-states
#20
Kelly Bruno, Sarah A Woller, Yury I Miller, Tony L Yaksh, Mark Wallace, Graham Beaton, Krishnan Chakravarthy
Toll-like receptors (TLRs) are a family of pattern-recognition receptors that initiate signaling in innate and adaptive immune pathways. The highly conserved family of transmembrane proteins are comprised of an extracellular domain that recognizes exogenous and endogenous danger molecules and an ectodomain that activates downstream pathways in response. Recent studies suggest that continuous activation or dysregulation of TLR signaling may contribute to chronic disease states. The receptor is located not only on inflammatory cells (meningeal and peripheral macrophages) but on neuraxial glia (microglia and astrocytes), schwann cells, fibroblasts, dorsal root ganglia and dorsal horn neurons...
June 7, 2018: Pain
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