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https://www.readbyqxmd.com/read/28644562/efficacy-of-ipragliflozin-as-monotherapy-or-as-add-on-therapy-with-other-oral-antidiabetic-medications-in-treating-type-2-diabetes-in-japanese-patients-with-inadequate-glycemic-control-a-subgroup-analysis-based-on-patient-characteristics
#1
Takeshi Osonoi, Shinya Nakamoto, Miyoko Saito, Atsuko Tamasawa, Hidenori Ishida, Yusuke Osonoi
AIMS/INTRODUCTION: The aim of the present study was to evaluate the efficacy and safety of ipragliflozin in treating Japanese type 2 diabetic patients with inadequate glycemic control by investigating diurnal variations of blood glucose and body composition. MATERIALS AND METHODS: This was an investigator-initiated, multicenter, prospective study with a 6-month treatment period. The primary outcome investigated was change in hemoglobin A1c levels from baseline. Secondary outcomes included changes in fasting plasma glucose, insulin resistance, variations in 24-h glucose levels detected by continuous glucose monitoring, body weight, body composition, waist circumference, and serum lipids...
June 23, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28629954/high-resolution-myelin-water-imaging-incorporating-local-tissue-susceptibility-analysis
#2
Zhe Wu, Hongjian He, Yi Sun, Yiping Du, Jianhui Zhong
Quantitative myelin water imaging (MWI) from signal T2* decay acquired with multiple Gradient-Recalled Echo (mGRE) sequence has been widely used since its first report. A recent study showed that with low resolution data (2mm isotropic voxels), direct application of complex fitting to a three-pool WM model with frequency shift terms could produce more stable parameter estimation for myelin water fraction mapping. MWI maps of higher spatial resolution resulting in more detailed tissue structures and reduced partial volume effects around white matter/gray matter (WM/GM) interface, however, is more desirable...
June 16, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28623475/t1-mapping-in-cardiac-mri
#3
REVIEW
Dina Radenkovic, Sebastian Weingärtner, Lewis Ricketts, James C Moon, Gabriella Captur
Quantitative myocardial and blood T1 have recently achieved clinical utility in numerous pathologies, as they provide non-invasive tissue characterization with the potential to replace invasive biopsy. Native T1 time (no contrast agent), changes with myocardial extracellular water (edema, focal or diffuse fibrosis), fat, iron, and amyloid protein content. After contrast, the extracellular volume fraction (ECV) estimates the size of the extracellular space and identifies interstitial disease. Spatially resolved quantification of these biomarkers (so-called T1 mapping and ECV mapping) are steadily becoming diagnostic and prognostically useful tests for several heart muscle diseases, influencing clinical decision-making with a pending second consensus statement due mid-2017...
June 16, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28611859/ipragliflozin-improves-glycemic-control-and-decreases-body-fat-in-patients-with-type-2-diabetes-mellitus
#4
Takehiro Kawata, Takashi Iizuka, Kotaro Iemitsu, Masahiro Takihata, Masahiko Takai, Shigeru Nakajima, Nobuaki Minami, Shinichi Umezawa, Akira Kanamori, Hiroshi Takeda, Shogo Ito, Taisuke Kikuchi, Hikaru Amemiya, Mizuki Kaneshiro, Atsuko Mokubo, Tetsuo Takuma, Hideo Machimura, Keiji Tanaka, Taro Asakura, Akira Kubota, Sachio Aoyanagi, Kazuhiko Hoshino, Masashi Ishikawa, Yoko Matsuzawa, Mitsuo Obana, Nobuo Sasai, Hideaki Kaneshige, Fuyuki Minagawa, Tatsuya Saito, Kazuaki Shinoda, Masaaki Miyakawa, Yasushi Tanaka, Yasuo Terauchi, Ikuro Matsuba
BACKGROUND: Ipragliflozin, a sodium-glucose transporter 2 inhibitor, was administered to patients with type 2 diabetes mellitus for 24 weeks to evaluate its effect on glycemic control and body composition. METHODS: This was an investigator-initiated multicenter prospective intervention study in which ipragliflozin (50 mg) was administered once daily and glycemic control, blood pressure, body weight (BW), body composition (measured by a biological impedance method), the lipid profile, and adverse events were evaluated after 4, 12, and 24 weeks of treatment...
July 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28601150/progress-and-challenges-of-fish-sperm-vitrification-a-mini-review
#5
REVIEW
Miaomiao Xin, Mohammad Abdul Momin Siddique, Borys Dzyuba, Rafael Cuevas-Uribe, Anna Shaliutina-Kolešová, Otomar Linhart
To survive low temperature is required for a long-term storage (cryopreservation), cells should be vitrified to a state in which intracellular water is solidified without ice crystal formation. Two different approaches are described for fish sperm cryopreservation: 1) sperm conventional cryopreservation, in which extracellular water is partially crystallized and 2) sperm vitrification, in which both intra- and extra-cellular liquids are vitrified. Sperm vitrification has been applied to some fish species with limited success...
August 2017: Theriogenology
https://www.readbyqxmd.com/read/28566445/muscle-strength-in-patients-with-acromegaly-at-diagnosis-and-during-long-term-follow-up
#6
Laila Maria Füchtbauer, Daniel S Olsson, Bengt-Åke Bengtsson, Lise-Lott Norrman, Katharina Sunnerhagen, Gudmundur Johannsson
OBJECTIVE: Patients with acromegaly have decreased body fat (BF), and increased extracellular water (ECW) and muscle mass. Although there is a lack of systematic studies on muscle function, it is believed that patients with acromegaly may suffer from proximal muscle weakness despite their increased muscle mass. We studied body composition and muscle function in untreated acromegaly and after biochemical remission. DESIGN: Prospective observational study Methods: Patients with acromegaly underwent measurements of muscle strength (dynamometers) and body composition (four-compartment model) at diagnosis (n=48), 1 year after surgery (n=29) and after long-term follow-up (median 11 years) (n=24)...
May 31, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28564640/impact-of-diabetes-on-extracellular-volume-status-in-patients-initiating-peritoneal-dialysis
#7
Aniema Udo, Catriona Goodlad, Andrew Davenport
BACKGROUND: Recent reports have highlighted that diabetic patients with kidney failure are at increased risk of technique failure and transfer to haemodialysis within 90 days of initiating peritoneal dialysis (PD). We wished to determine whether there were differences between diabetic and non-diabetic patients within the first 3 months of starting PD. METHODS: We reviewed results of corresponding bioimpedance and the 1st test of peritoneal membrane function (PET) in consecutive patients, 6-10 weeks after initiating PD electively...
June 1, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28545164/loss-of-appendicular-muscle-mass-in-haemodialysis-patients-is-associated-with-increased-self-reported-depression-anxiety-and-lower-general-health-scores
#8
Helen Alston, Aine Burns, Andrew Davenport
AIMS: Depressive symptoms are commonly reported by haemodialysis (HD) patients. Previous reports have suggested an association between depression and nutritional status. To investigate this, we measured muscle mass in HD patients screened for depression. METHODS: The Beck Depression Inventory-II (BDI-II), Hospital Anxiety and Depression Scale (HADS) were used to screen for depression, and quality of life assessed by the short form 36 (SF36), and measured appendicular lean mass (ALM) post-dialysis with segmental bioimpedance...
May 25, 2017: Nephrology
https://www.readbyqxmd.com/read/28528793/comparison-of-dual-energy-x-ray-absorptiometry-and-bioimpedance-in-assessing-body-composition-and-nutrition-in-peritoneal-dialysis-patients
#9
Velena Popovic, Bo Zerahn, James Goya Heaf
OBJECTIVE: Peritoneal dialysis (PD) patients are characterized by protein malnutrition and muscle wasting. Reliable, easy, and cheap methods for evaluating nutrition are desirable. Three methods are commonly available: dual-energy X-ray absorptiometry (DXA), bioimpedance (BI), and subjective global assessment (SGA).The objective of the study was to compare the previously mentioned methods for assessment of body composition and nutritional status in PD patients. DESIGN: The study is cross-sectional and consisted of 72 PD patients from a single center PD ambulatorium...
May 18, 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/28512162/increase-in-extracellular-hydration-status-after-initiating-peritoneal-dialysis-electively
#10
Kwanpeemai Panorchan, Andrew Davenport
Renal replacement therapy is designed to treat uremic symptoms and correct hypervolemia. We hypothesized that starting peritoneal dialysis (PD) should reduce overhydration, and we measured body composition and hydration status using bioimpedance in PD patients prior to training and then at the first assessment of peritoneal membrane function. We studied 100 consecutive patients with a planned start to PD, without peritoneal infections or mechanical catheter problems, mean age 54.7 ± 17.1 years, 57% male and 25% diabetic...
May 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28428209/myelin-detection-using-rapid-quantitative-mr-imaging-correlated-to-macroscopically-registered-luxol-fast-blue-stained-brain-specimens
#11
J B M Warntjes, A Persson, J Berge, W Zech
BACKGROUND AND PURPOSE: Myelin detection is of great value in monitoring diseases such as multiple sclerosis and dementia. However, most MR imaging methods to measure myelin are challenging for routine clinical use. Recently, a novel method was published, in which the presence of myelin is inferred by using its effect on the intra- and extracellular water relaxation rates and proton density, observable by rapid quantitative MR imaging. The purpose of this work was to validate this method further on the brains of 12 fresh, intact cadavers...
April 20, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28365067/the-utility-of-a-phase-angle-analysis-in-patients-with-severe-motor-and-intellectual-disabilities
#12
Motomu Yoshida, Kimio Asagiri, Suguru Fukahori, Yoshiaki Tanaka, Naoki Hashizume, Shinji Ishii, Nobuyuki Saikusa, Naruki Higashidate, Daisuke Masui, Naoko Komatsuzaki, Hirotomo Nakahara, Minoru Yagi, Yushiro Yamashita
PURPOSE: The purpose of the present study was to evaluate whether evaluating the phase angle (PhA), in a bioelectrical impedance analysis (BIA) is useful for estimating the nutritional status of severe motor and intellectual disabilities (SMID) patients. SUBJECTS AND METHODS: This retrospective study included 31 SMID patients (mean age: 33.9±13.5years, median age: 29years (range: 18-58years), male/female: 23/8). First, each of the parameters from the total study population and the male and female SMID patients were compared with those of healthy Asian subjects...
March 29, 2017: Brain & Development
https://www.readbyqxmd.com/read/28348381/greater-extracellular-free-water-in-first-episode-psychosis-predicts-better-neurocognitive-functioning
#13
A E Lyall, O Pasternak, D G Robinson, D Newell, J W Trampush, J A Gallego, M Fava, A K Malhotra, K H Karlsgodt, M Kubicki, P R Szeszko
Free Water Imaging is a novel diffusion magnetic resonance (MR) imaging method that is able to separate changes affecting the extracellular space from those that reflect changes in neuronal cells and processes. A previous Free Water Imaging study in schizophrenia identified significantly greater extracellular water volume in the early stages of the disorder; however, its clinical and functional sequelae have not yet been investigated. Here, we applied Free Water Imaging to a larger cohort of 63 first-episode patients with psychosis and 70 healthy matched controls to better understand the functional significance of greater extracellular water...
March 28, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28319679/evaluation-of-body-composition-with-bioimpedence-a-comparison-between-athletic-and-non-athletic-children
#14
Domenico Meleleo, Nicola Bartolomeo, Liliana Cassano, Alessandro Nitti, Giovanna Susca, Giuseppina Mastrototaro, Umberto Armenise, Annapaola Zito, Fiorella Devito, Pietro Scicchitano, Marco Matteo Ciccone
PURPOSE: Conventional Bioelectrical Impedance Analysis (BIA) or Bioelectrical Impedance Vector Analysis (BIVA) can provide direct evaluations of body composition. The purpose of this study was to evaluate lean and fat mass (FM), and hydration of children involved in daily competitive sports. METHODS: 190 non-athletic [8.2-10.5 years] and 29 competitive children [8.0-10.5 years] were enrolled. They were evaluated: at baseline (t0), 6 months (t1) and one year (t2)...
July 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28295857/single-frequency-and-multi-frequency-bioimpedance-analysis-what-is-the-difference
#15
Serkan Feyyaz Yalın, Sibel Gulcicek, Suna Avci, Banu Erkalma Senates, Mehmet Riza Altıparmak, Sinan Trabulus, Selma Alagoz, Hakan Yavuzer, Alper Doventas, Nurhan Seyahi
AIM: Bioelectrical impedance analysis is a promising method in determining the body compartments in hemodialysis patients. In this study, we aimed to investigate the agreement between two widely used methods: the single-frequency and multi-frequency bioelectrical impedance analyses. METHODS: Maintenance hemodialysis patients were enrolled in the study. Single-frequency and multi-frequency bioelectrical impedance analyses were performed consecutively before hemodialysis...
March 10, 2017: Nephrology
https://www.readbyqxmd.com/read/28271257/outcomes-of-diuretic-use-in-pre-dialysis-ckd-patients-with-moderate-renal-deterioration-attending-tertiary-care-referral-center
#16
Yusra Habib Khan, Azmi Sarriff, Azreen Syazril Adnan, Amer Hayat Khan, Tauqeer Hussain Mallhi
INTRODUCTION: Diuretic therapy has been the mainstay of treatment in chronic kidney disease (CKD) patients, primarily for hypertension and fluid overload. Apart from their beneficial effects, diuretic use is associated with adverse renal outcomes. The current study is aimed to determine the outcomes of diuretic therapy. METHODOLOGY: A prospective observational study was conducted by inviting pre-dialysis CKD patients. Fluid overload was assessed by Bioimpedance analysis (BIA)...
March 7, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28258890/water-exchange-rate-constant-as-a-biomarker-of-treatment-efficacy-in-patients-with-brain-metastases-undergoing-stereotactic-radiosurgery
#17
Hatef Mehrabian, Kimberly L Desmond, Sofia Chavez, Colleen Bailey, Radoslaw Rola, Arjun Sahgal, Gregory J Czarnota, Hany Soliman, Anne L Martel, Greg J Stanisz
PURPOSE: This study was designed to evaluate whether changes in metastatic brain tumors after stereotactic radiosurgery (SRS) can be seen with quantitative MRI early after treatment. METHODS AND MATERIALS: Using contrast-enhanced MRI, a 3-water-compartment tissue model consisting of intracellular (I), extracellular-extravascular (E), and vascular (V) compartments was used to assess the intra-extracellular water exchange rate constant (kIE), efflux rate constant (kep), and water compartment volume fractions (M0,I, M0,E, M0,V)...
May 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28255913/body-composition-anthropometric-indices-and-hydration-status-of-obstructive-sleep-apnea-patients-can-cachexia-coexist-with-obesity
#18
Barbara Kuźnar-Kamińska, Marcin Grabicki, Tomasz Trafas, Monika Szulińska, Szczepan Cofta, Tomasz Piorunek, Beata Brajer-Luftmann, Agata Nowicka, Barbara Bromińska, Halina Batura-Gabryel
The aim of this study was to elucidate body composition, anthropometric indices, and hydration status in obstructive sleep apnea (OSA) patients, taking into account different disease stages, gender, and the possibility of the presence of cachexia. There were 98 OSA patients and 23 control subjects enrolled into the study. All study participants underwent polysomnography examination. Body mass index (BMI), fat mass index (FMI), fat free mass, muscle mass, body cell mass, total body water, and extracellular and intracellular water were evaluated...
March 3, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28255797/acetate-buffered-crystalloid-infusate-versus-infusion-of-0-9-saline-and-hemodynamic-stability-in-patients-undergoing-renal-transplantation-prospective-randomized-controlled-trial
#19
Carmen Pfortmueller, Georg-Christian Funk, Eva Potura, Christian Reiterer, Florian Luf, Barbara Kabon, Wilfred Druml, Edith Fleischmann, Gregor Lindner
BACKGROUND: Infusion therapy is one of the most frequently prescribed medications in hospitalized patients. Currently used crystalloid solutes have a variable composition and may therefore influence acid-base status, intracellular and extracellular water content and plasma electrolyte compositions and have a major impact on organ function and outcome. The aim of our study was to investigate whether use of acetate-based balanced crystalloids leads to better hemodynamic stability compared to 0...
March 2, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28236490/does-lymphadenectomy-have-influence-on-postoperative-body-fluid-distribution
#20
Tolgay Tuyan İlhan, Mustafa Gazi Uçar, Aybike Tazegül Pekin, Setenay Arzu Yılmaz, Özlem Seçilmiş Kerimoğlu, Çetin Çelik
OBJECTIVE: We compared the fluid volume parameters in women undergoing gynaecological surgery for benign and malignant conditions before and after surgery using bioelectrical impedance vectors. STUDY DESIGN: A total of 181 patients were enrolled. In all, 89 patients had surgery for benign conditions and 92 patients underwent oncological procedures, including lymph node dissection, for malignant diseases. Bioelectrical impedance analysis (BIA) parameters were measured on the day of hospitalisation before any treatment and at 24h and 1 month after the surgical intervention...
May 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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