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https://www.readbyqxmd.com/read/29151001/intravenous-fluid-therapy-for-hospitalized-and-critically-ill-children-rationale-available-drugs-and-possible-side-effects
#1
Thomas Langer, Rosamaria Limuti, Concezione Tommasino, Niels van Regenmortel, Els L I M Duval, Pietro Caironi, Manu L N G Malbrain, Antonio Pesenti
Human beings are constituted mainly of water. In particular, children's total body water might reach 75-80% of their body weight, compared to 60-70% in adults. It is therefore not surprising, that children, especially hospitalized newborns and infants, are markedly prone to water and electrolyte imbalances. Parenteral fluid therapy is a cornerstone of medical treatment and is thus of exceptional relevance in this patient population. It is crucial to appreciate the fact that intravenous fluids are drugs with very different characteristics, different indications, contraindications and relevant side effects...
November 18, 2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/29150589/change-in-hydration-indices-associated-with-an-increase-in-total-water-intake-of-more-than-0-5%C3%A2-l-day-sustained-over-4%C3%A2-weeks-in-healthy-young-men-with-initial-total-water-intake-below-2%C3%A2-l-day
#2
Jodi D Stookey, Janice Hamer, David W Killilea
This secondary data analysis addressed gaps in knowledge about effects of chronic water intake. Longitudinal data from the Adapt Study were used to describe effects of prescribing a sustained increase in water intake relative to baseline, for 4 weeks, on multiple indices of total body water (TBW) flux, regulation, distribution, and volume in five healthy, free-living, young men, with mean total water intake initially below 2 L/day. Indices were measured weekly. Within-person fixed effect models tested for significant changes in indices over time and associations between changes in indices...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29145537/the-role-of-iron-in-type-1-diabetes-etiology-a-systematic-review-of-new-evidence-on-a-long-standing-mystery
#3
Karen L Søgaard, Christina Ellervik, Jannet Svensson, Steffen U Thorsen
BACKGROUND: The incidence of type 1 diabetes (T1D) is rising, which might be due to the influence of environmental factors. Biological and epidemiological evidence has shown that excess iron is associated with beta-cell damage and impaired insulin secretion. AIM: In this review, our aim was to assess the association between iron and the risk of T1D. METHODS: A systematic literature search was performed in PubMed and EMBASE in July 2016. Studies investigating the effect of iron status/intake on the risk of developing T1D later were included, and study quality was evaluated...
July 2017: Review of Diabetic Studies: RDS
https://www.readbyqxmd.com/read/29140134/a-nutrition-recovery-station-following-recreational-exercise-improves-fruit-consumption-but-does-not-influence-fluid-recovery
#4
Ben Desbrow, Katelyn Barnes, Caroline Young, Gregory R Cox, Chris Irwin
Immediate post-exercise access to fruit/fluid via a recovery "station" is a common feature of mass participation sporting events. Yet little evidence exists examining their impact on subsequent dietary intake. The aim of this study was to determine if access to fruit/water/sports drinks within a recovery station significantly alters dietary and fluid intakes in the immediate post-exercise period and influences hydration status the next morning. 127 (79 males) healthy participants (mean±SD, age=22.5±3.5y, body mass (BM)=73±13kg) completed two self-paced morning 10km runs separated by 1 week...
November 15, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29139077/spatiotemporal-patterns-and-source-attribution-of-nitrogen-pollution-in-a-typical-headwater-agricultural-watershed-in-southeastern-china
#5
Wenjun Chen, Bin He, Daniel Nover, Weili Duan, Chuan Luo, Kaiyan Zhao, Wen Chen
Excessive nitrogen (N) discharge from agriculture causes widespread problems in aquatic ecosystems. Knowledge of spatiotemporal patterns and source attribution of N pollution is critical for nutrient management programs but is poorly studied in headwaters with various small water bodies and mini-point pollution sources. Taking a typical small watershed in the low mountains of Southeastern China as an example, N pollution and source attribution were studied for a multipond system around a village using the Hydrological Simulation Program-Fortran (HSPF) model...
November 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29134152/the-role-of-mef2-transcription-factors-in-dehydration-and-anoxia-survival-in-rana-sylvatica-skeletal-muscle
#6
Myriam P Hoyeck, Hanane Hadj-Moussa, Kenneth B Storey
The wood frog (Rana sylvatica) can endure freezing of up to 65% of total body water during winter. When frozen, wood frogs enter a dormant state characterized by a cessation of vital functions (i.e., no heartbeat, blood circulation, breathing, brain activity, or movement). Wood frogs utilize various behavioural and biochemical adaptations to survive extreme freezing and component anoxia and dehydration stresses, including a global suppression of metabolic functions and gene expression. The stress-responsive myocyte enhancer factor-2 (MEF2) transcription factor family regulates the selective expression of genes involved in glucose transport, protein quality control, and phosphagen homeostasis...
2017: PeerJ
https://www.readbyqxmd.com/read/29131947/on-line-differential-thermal-isotope-analysis-of-hydration-water-in-minerals-by-cavity-ring-down-laser-spectroscopy
#7
Thomas K Bauska, Gregory Walters, Fernando Gázquez, David Hodell
We have developed a new method for measuring the isotopic composition (δ18O and δD) of different types of bonded water (e.g., molecular water, hydroxyl) contained in hydrated minerals by coupling a thermal gravimeter (TG) and a cavity ringdown laser spectrometer (CRDS). The method involves precisely step-heating a mineral sample, allowing the separation of the different types of waters that are released at different temperatures. Simultaneously, the water vapor evolved from the mineral sample is analysed for oxygen and hydrogen isotopes by CRDS...
November 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29128090/crocus-sativus-l-aqueous-extract-reduces-atherogenesis-increases-atherosclerotic-plaque-stability-and-improves-glucose-control-in-diabetic-atherosclerotic-animals
#8
Ei Christodoulou, N P E Kadoglou, M Stasinopoulou, O A Konstandi, C Kenoutis, Z I Kakazanis, A Rizakou, N Kostomitsopoulos, G Valsami
BACKGROUND AND AIMS: We aimed to evaluate a possible atheroprotective effect of saffron aqueous extract (SFE), and its potential anti-inflammatory mechanisms, in apoE knockout (ApoE(-/-)) mice. METHODS: Fifty male, ApoE(-/-) mice, fed a high-fat diet (HFD) for 12 weeks, were randomized into 5 groups: (1) baseline group, euthanatized, without intervention, (2) three saffron groups, receiving HFD and 30,60,90 mg/kg/day of SFE, respectively, for four weeks, per os through gavage, after reconstitution in water for injection (WFI), (3) control group (COG), receiving daily HFD and the same volume of WFI (four weeks)...
November 1, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29124970/a-review-on-the-nucleic-acid-constituents-in-mushrooms-nucleobases-nucleosides-and-nucleotides
#9
Chia-Wei Phan, Joon-Keong Wang, Shiau-Chuen Cheah, Murali Naidu, Pamela David, Vikineswary Sabaratnam
Mushrooms have become increasingly important as a reliable food source. They have also been recognized as an important source of bioactive compounds of high nutritional and medicinal values. The nucleobases, nucleosides and nucleotides found in mushrooms play important roles in the regulation of various physiological processes in the human body via the purinergic and/or pyrimidine receptors. Cordycepin, a 3'-deoxyadenosine found in Cordyceps sinensis has received much attention as it possesses many medicinal values including anticancer properties...
November 10, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/29121875/effect-of-short-term-diet-restriction-on-gene-expression-in-the-bovine-hypothalamus-using-next-generation-rna-sequencing-technology
#10
Daragh Matthews, Michael G Diskin, David A Kenny, Christopher J Creevey, Kate Keogh, Sinead M Waters
BACKGROUND: Negative energy balance (NEB) is an imbalance between energy intake and energy requirements for lactation and body maintenance affecting high-yielding dairy cows and is of considerable economic importance due to its negative impact on fertility and health in dairy herds. It is anticipated that the cow hypothalamus experiences extensive biochemical changes during the early post partum period in an effort to re-establish metabolic homeostasis. However, there is variation in the tolerance to NEB between individual cows...
November 9, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29121115/the-response-of-gene-expression-associated-with-lipid-metabolism-fat-deposition-and-fatty-acid-profile-in-the-longissimus-dorsi-muscle-of-gannan-yaks-to-different-energy-levels-of-diets
#11
Chao Yang, Jianbin Liu, Xiaoyun Wu, Pengjia Bao, Ruijun Long, Xian Guo, Xuezhi Ding, Ping Yan
The energy available from the diet, which affects fat deposition in vivo, is a major factor in the expression of genes regulating fat deposition in the longissimus dorsi muscle. Providing high-energy diets to yaks might increase intramuscular fat deposition and fatty acid concentrations under a traditional grazing system in cold seasons. A total of fifteen adult castrated male yaks with an initial body weight 274.3 ± 3.14 kg were analyzed for intramuscular adipose deposition and fatty acid composition. The animals were divided into three groups and fed low-energy (LE: 5...
2017: PloS One
https://www.readbyqxmd.com/read/29115801/the-relationship-between-the-vitamin-serum-25-oh-d-and-the-b12-concentrations-in-obese-women
#12
Nikola Curic, Branislava Ilincic, Natasa Milic, Velibor Cabarkapa, Stanislava Nikolic, Milica Medic-Stojanoska, Rinaldo Pellicano, Ludovico Abenavoli
BACKGROUND: In obesity, low levels of vitamin D (VD) and vitamin B12 (VB12), may be the result of different pathophysiological mechanisms, but the possible association between them has not yet been defined. The aim of this cross-sectional analysis was to investigate the possible relationship between serum 25-hydroxyvitamin D (25(OH)D) and VB12 levels in middle aged women. METHODS: In 80 women, we indirectly evaluated body composition and body volumes [extracellular fluid volume (ECV) and total body water (TBW)] by anthropometric and bioelectrical impedance analysis...
November 7, 2017: Minerva Medica
https://www.readbyqxmd.com/read/29115200/barley-%C3%AE-glucan-reduces-blood-cholesterol-levels-via-interrupting-bile-acid-metabolism
#13
Yanan Wang, Scott V Harding, Sijo J Thandapilly, Susan M Tosh, Peter J H Jones, Nancy P Ames
Underlying mechanisms responsible for the cholesterol-lowering effect of β-glucan have been proposed, yet have not been fully demonstrated. The primary aim of this study was to determine whether the consumption of barley β-glucan lowers cholesterol by affecting the cholesterol absorption, cholesterol synthesis or bile acid synthesis. In addition, this study was aimed to assess whether the underlying mechanisms are related to cholesterol 7α hydroxylase (CYP7A1) SNP rs3808607 as proposed by us earlier. In a controlled, randomised, cross-over study, participants with mild hypercholesterolaemia (n 30) were randomly assigned to receive breakfast containing 3 g high-molecular weight (HMW), 5 g low-molecular weight (LMW), 3 g LMW barley β-glucan or a control diet, each for 5 weeks...
November 8, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29114120/free-living-amoebae-in-the-water-resources-of-iran-a-systematic-review
#14
REVIEW
Ehsan Saburi, Toktam Rajaii, Asma Behdari, Mohammad Hasan Kohansal, Hossein Vazini
Free-living amoebae (FLA) are a group of protozoa with the capabilities of growth in the environment and invasion to the human body which have been isolated from different water sources. Acanthamoeba, Naegleria, and Balamuthia are the most important FLA. These cause a variety of severe complications of eye and central nervous system. Despite the fact that various studies have demonstrated the prevalence of FLA in different parts of Iran, there is no comprehensive evaluation and conclusion regarding the pollution of various water sources in Iran...
December 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/29112842/occurrence-and-geodatabase-mapping-of-three-contaminants-of-emerging-concern-in-receiving-water-and-at-effluent-from-waste-water-treatment-plants-a-first-overview-of-the-situation-in-the-republic-of-ireland
#15
REVIEW
Alexandre Tahar, Erin Jo Tiedeken, Neil J Rowan
This constitutes the first study to address occurrence and geodatabase mapping of the anti-inflammatory drug diclofenac (DCL) and the natural (17-beta-estradiol or E2) and synthetic (17-alpha-ethynylestradiol or EE2) estrogenic hormones in Republic of Ireland receiving waters over the period 1999 to 2015. Among these data, 317 samples came from concentration studies, while 205 were from effect-based studies. Monitoring data came from 16 waste water treatment plants (WWTPs), 23 water bodies (including rivers, lakes, marine and transitional waters) and 7 from domestic locations...
November 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29111193/antioxidant-and-diuretic-activity-of-co-administration-of-capparis-spinosa-honey-and-propolis-in-comparison-to-furosemide
#16
Soukaina El-Guendouz, Noori Al-Waili, Smail Aazza, Youssef Elamine, Soumia Zizi, Thia Al-Waili, Ali Al-Waili, Badiaa Lyoussi
OBJECTIVE: To study the antioxidant properties of Capparis spinosa (C. spinosa) honey and propolis and the effect of combined honey and propolis administration on urine volume and electrolytes in rats. METHODS: C. spinosa honey [1000 mg/kg body weight (b.wt)], propolis (100 mg/kg b.wt), honey/propolis mixture (C. spinosa honey 1000 mg/kg b.wt/ propolis extract 100 mg/kg b.wt ), distilled water (1 mL/kg b.wt) and furosemide (10 mg/kg b.wt) were orally administered to five groups of rats for 21 d...
October 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29108055/effects-of-in-ovo-feeding-of-l-arginine-on-hatchability-hatching-time-early-posthatch-development-and-carcass-traits-in-domestic-pigeons-columba-livia
#17
X Y Zhang, X P Wan, L P Miao, X T Zou, X Y Dong
The objective of this research was to test the hypothesis that in ovo feeding of arginine (Arg) may improve hatchability and posthatch performance in domestic pigeons (). A completely randomized design ( = 3) with an Arg feeding treatment (Arg group, 1.14 mg Arg dissolved in 200 μL of 0.75% NaCl buffered saline as 1% concentration compared to total Arg in the egg), a buffered saline feeding treatment (SC group, 7.5 g NaCl dissolved in 1 L sterile distilled water as the concentration of poultry physiological saline), and a nonfeeding treatment (NC group) was used...
October 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/29107373/evaluation-of-mercury-in-a-freshwater-environment-impacted-by-an-organomercury-fungicide-using-diffusive-gradient-in-thin-films
#18
Marta Turull, Tatiana Komarova, Barry Noller, Clàudia Fontàs, Sergi Díez
The use of pesticides to manage pest problems for crop protection is common practice around the world, and their accumulation in soils and contamination of water bodies is a global environmental problem. In Australia, an organomercury (Hg)-based fungicide is the most popular for control of pineapple disease of sugarcane. However, the presence of Hg is of great concern because of potential adverse effects in the environment. The purpose of this work was to evaluate the residual levels of Hg in soils of sugarcane cultivation from a catchment in North Queensland (Australia)...
October 26, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29107008/acute-and-a-28-day-repeated-dose-toxicity-study-of-total-flavonoids-from-clinopodium-chinense-benth-o-ktze-in-mice-and-rats
#19
Yonglin Gao, Yunzhi Wang, Kezhou Wang, Jing Zhu, Guisheng Li, Jingwei Tian, Chunmei Li, Zhenhua Wang, Ji Li, Albert W Lee, Chenghua Guo
Clinopodium chinense (Benth.) O. Ktze (Labiatae), known as 'Duanxueliu' in the Chinese Pharmacopoeia, has been widely used as a traditional Chinese medicine for the treatment of hemorrhagic disease. Total flavonoids from Clinopodium chinense (Benth.) O. Ktze (TFCC), the most active ingredient, possess a variety of properties, such as antioxygenation. Until now, evidence-based toxicity data on TFCC has been limited. This study evaluated the acute (in mice and rat) and the 28-day repeated-dose (in rat) toxicity study of TFCC, respectively...
October 30, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29103469/improved-clinical-workflow-for-simultaneous-whole-body-pet-mri-using-high-resolution-caipirinha-accelerated-mr-based-attenuation-correction
#20
Martin T Freitag, Matthias Fenchel, Philipp Bäumer, Thorsten Heußer, Christopher M Rank, Marc Kachelrieß, Daniel Paech, Klaus Kopka, Sebastian Bickelhaupt, Antonia Dimitrakopoulou-Strauss, Klaus Maier-Hein, Ralf Floca, Mark E Ladd, Heinz-Peter Schlemmer, Florian Maier
PURPOSE: To explore the value and reproducibility of a novel magnetic resonance based attenuation correction (MRAC) using a CAIPIRINHA-accelerated T1-weighted Dixon 3D-VIBE sequence for whole-body PET/MRI compared to the clinical standard. METHODS: The PET raw data of 19 patients from clinical routine were reconstructed with standard MRAC (MRACstd) and the novel MRAC (MRACcaipi), a prototype CAIPIRINHA accelerated Dixon 3D-VIBE sequence, both acquired in 19 s/bed position...
November 2017: European Journal of Radiology
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