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Noninvasive fat reduction

Abbas Majdabadi, Mohammad Abazari
BACKGROUND/AIM: Regarding previous problems in conventional liposuction methods, the need for development of new fat removal operations was appreciated. In this study we are going to simulate one of the novel methods, cryolipolysis, aimed to tackle those drawbacks. MATERIALS AND METHODS: We think that simulation of clinical procedures contributes considerably in efficacious performance of the operations. To do this we have attempted to simulate temperature distribution in a sample fat of the human body...
December 20, 2016: Turkish Journal of Medical Sciences
Ava T Shamban
BACKGROUND: KYBELLA, ATX-101, is an injectable form of sodium deoxycholic acid. It is currently the only Food and Drug Administration-approved injectable drug for the reduction of submental fat. OBJECTIVES: A literature review and discussion of the treatment of submental fat. RESULTS: KYBELLA is a well-tolerated alternative for the treatment of submental fat. CONCLUSIONS: KYBELLA is a safe and efficacious, first in class, injectable drug for the reduction of submental fat...
December 2016: Plastic and Reconstructive Surgery. Global Open
William P Coleman, William Coleman, Robert A Weiss, Jeffrey M Kenkel, Dean D Ad-El, Ruthie Amir
BACKGROUND: Demand for nonsurgical esthetic body procedures has led to the development of noninvasive techniques for reducing localized subcutaneous adipose tissue. OBJECTIVE: This study assessed multiple treatments with nonthermal focused ultrasound for noninvasive abdominal treatment of excess fat deposits. MATERIALS AND METHODS: Subjects were randomly assigned to Group 1 for a 4-week control phase before undergoing 3 abdominal fat reduction treatments, at 2-week intervals, or to Group 2 for immediate treatment...
January 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Patricia Froes Meyer, Rodrigo Marcel Valentim da Silva, Glenda Oliveira, Maely Azevedo da Silva Tavares, Melyssa Lima Medeiros, Camila Procopio Andrada, Luis Gonzaga de Araujo Neto
Cryolipolysis is a noninvasive technique of localized fat reduction. Controlled cold exposure is performed in the selective destruction of fat cells. The aim of this study was to investigate the effects of cryolipolysis on adipocytes elimination through histological and sonographic analyses. This study reports the case of a 46-year-old female patient, with complaint of localized abdominal fat and in the preoperative period of abdominoplasty. The patient was submitted to a single 60-minute application of cryolipolysis, temperature of -5°C, on the hypogastrium area, 5 cm below the umbilicus...
2016: Case Reports in Dermatological Medicine
Janki Patel, Ricki Bettencourt, Jeffrey Cui, Joanie Salotti, Jonathan Hooker, Archana Bhatt, Carolyn Hernandez, Phirum Nguyen, Hamed Aryafar, Mark Valasek, William Haufe, Catherine Hooker, Lisa Richards, Claude B Sirlin, Rohit Loomba
BACKGROUND: Magnetic resonance imaging-estimated proton-density-fat-fraction (MRI-PDFF) has been shown to be a noninvasive, accurate and reproducible imaging-based biomarker for assessing steatosis and treatment response in nonalcoholic steatohepatitis (NASH) clinical trials. However, there are no data on the magnitude of MRI-PDFF reduction corresponding to histologic response in the setting of a NASH clinical trial. The aim of this study was to quantitatively compare the magnitude of MRI-PDFF reduction between histologic responders versus histologic nonresponders in NASH patients...
September 2016: Therapeutic Advances in Gastroenterology
S Y Jeong, T R Kwon, J Seok, K Y Park, B J Kim
BACKGROUND/PURPOSE: The growing demand for a youthful appearance, including a favorable body shape, has motivated recent developments in noninvasive body contouring techniques. Our aim was to investigate the efficacy and safety of a new version of a 4D handpiece-mounted cooling device for cryolipolysis with or without tumescent injections. METHODS: We conducted a side-by-side comparative study using two female porcine models. Two areas of each pig's left abdomen were treated using a conventional device and the new cooling device, and two areas of the right abdomen were also treated using the conventional and new cooling device, but both were combined with tumescent-solution injections...
July 20, 2016: Skin Research and Technology
Ji-Hye Park, Jung-In Kim, Hee Jin Park, Won-Serk Kim
Recently, a number of modalities have been used for noninvasive fat reduction. Radiofrequency (RF) technology is a promising tool for noninvasive body and face contouring. The aim of this study is to evaluate the efficacy and safety of novel noninvasive RF technology for the reduction of submental fat with 6 months of follow-up. Twenty-one subjects with submental fat accumulation were treated twice at 1-month intervals with monopolar RF, which could also be used to monitor real-time temperature. The submental fat thickness and the circumference were evaluated with ultrasonography and a tape measure, respectively, at baseline followed by 1 and 6 months after the last treatment (0, 2, and 7 months)...
November 2016: Lasers in Medical Science
Eric F Bernstein
Cryolipolysis is a noninvasive esthetic procedure that utilizes controlled cooling to reduce subcutaneous fat. Clinical studies have established its safety, efficacy, and tolerability for fat reduction in a variety of areas including the abdomen, flanks, thighs, submental area, arms, back, and chest. Because of obvious esthetic concerns, long-term unilateral studies leaving an untreated flank, thigh, or arm are not performed, but serve as ideal controls for weight gain or loss or re-distribution of fat for other reasons...
June 23, 2016: Journal of Cosmetic Dermatology
Xin-Yi Liu, Ming Jin, Zhi-Qiang Wang, Dan-Ni Wang, Jun-Jie He, Min-Ting Lin, Hong-Xia Fu, Ning Wang
BACKGROUND: Lipid storage myopathy (LSM) is a genetically heterogeneous group with variable clinical phenotypes. Late-onset multiple acyl-coenzyme A dehydrogenation deficiency (MADD) is a rather common form of LSM in China. Diagnosis and clinical management of it remain challenging, especially without robust muscle biopsy result and genetic detection. As the noninvasion and convenience, muscle magnetic resonance imaging (MRI) is a helpful assistant, diagnostic tool for neuromuscular disorders...
June 20, 2016: Chinese Medical Journal
Klaus Fritz, Carmen Salavastru
For skin tightening, ablative and nonablative lasers have been used with various parameters full or fractionated. Currently, other energy-based technologies have been developed such as radiofrequency (RF) from mono- to multipolar, microneedling RF, and high-intensity focused ultrasound. They heat up the tissue to a clinical endpoint. Temperatures above 42°C stimulate fibroblasts to produce more collagen and some technologies produce small coagulation points that allow to shrink and to tighten the tissue with less downtime or side effects...
June 2016: Facial Plastic Surgery: FPS
Lena J Vogt, Antje Steveling, Peter J Meffert, Marie-Luise Kromrey, Rebecca Kessler, Norbert Hosten, Janine Krüger, Simone Gärtner, Ali A Aghdassi, Julia Mayerle, Markus M Lerch, Jens-Peter Kühn
OBJECTIVES: To investigate changes in the fat content of abdominal compartments and muscle area during weight loss using confounder-adjusted chemical-shift-encoded magnetic resonance imaging (MRI) in overweight diabetics. METHODS: Twenty-nine obese diabetics (10/19 men/women, median age: 59.0 years, median body mass index (BMI): 34.0 kg/m2) prospectively joined a standardized 15-week weight-loss program (six weeks of formula diet exclusively, followed by reintroduction of regular food with gradually increasing energy content over nine weeks) over 15 weeks...
2016: PloS One
Jeanine Downie, Miroslav Kaspar
BACKGROUND: Noninvasive body shaping methods seem to be an ascending part of the aesthetics market. As a result, the pressure to develop reliable methods for the collection and presentation of their results has also increased. The most used techniques currently include ultrasound measurements of fat thickness in the treated area, caliper measurements, bioimpedance-based scale measurements or circumferential tape measurements. Although these are the most used techniques, almost all of them have some limitations in reproducibility and/or accuracy...
April 2016: Journal of Drugs in Dermatology: JDD
Diane Irvine Duncan, Theresa H M Kim, Robbin Temaat
To date, there have been no objective measurements of subcutaneous volume loss following treatments with a noninvasive radiofrequency (RF)-based device. Twenty female patients were treated with a suction-coupled bipolar RF device using external RF energy combined with pulsed electromagnetic RF energy for subcutaneous fat reduction. Parameters followed included weight, Vectra measurements of abdominal circumference and torso volume, and high-definition ultrasound measurements of fat thickness. Measurements were taken before treatment and three times following treatment...
October 2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
Diane Irvine Duncan, Theresa H M Kim, Robbin Temaat
Noninvasive fat reduction is claimed by many device manufacturers, but proof of efficacy has been difficult to establish. This prospective study was designed to measure the reduction of fat thickness and actual volume reduction in 20 female patients treated with an external radiofrequency (RF) device. This device combines RF heat, suction coupled vacuum, and oscillating electrical pulses that induce adipocyte death over time. Patients underwent pre- and post-treatment and intercurrent measurements of weight, body mass index, ultrasonic transcutaneous fat thickness, and 2D and 3D Vectra photography with independent calculation of circumferential and volumetric change...
October 2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
Maricruz Crespo, Sara Lappe, Ariel E Feldstein, Naim Alkhouri
Nonalcoholic fatty liver disease (NAFLD) is highly common and potentially serious in children and adolescents. The term NAFLD refers to a spectrum of diseases ranging from accumulation of fat in the liver (simple steatosis or nonalcoholic fatty liver "NAFL") to the potentially progressive form of nonalcoholic steatohepatitis (NASH) characterized by hepatocyte ballooning, inflammation, and often associated with fibrosis. While large prospective longitudinal studies in pediatric NAFLD are still lacking, growing evidence suggests that children with NAFL are at increased risk for cardiometabolic complications, while those with NASH and advance fibrosis are also at risk for significant liver-related morbidity including cirrhosis and its complications...
August 2016: Metabolism: Clinical and Experimental
Amany A Mousa, Mohamed Ghonem, El Hadidy M Elhadidy, Emad Azmy, Magda Elbackry, Azza A Elbaiomy, Rasha R Elzehery, Gehan A Shaker, Omyma Saleh
OBJECTIVE: to assess the growth and pubertal development among a group of patients with β-Thalassemia Major (β-TM) and to evaluate the role of the pituitary gland and liver MRI signal intensity (SI) reduction in assessing and predicting the clinical severity of growth and pubertal dysfunctions. METHODS: Thirty-eight patients with β-TM were examined and divided into two groups: Group I patients were of normal height and puberty and Group II patients had short statures and hypogonadism...
May 2016: Endocrine Research
Shyue-Luen Chang, Yau-Li Huang, Mei-Ching Lee, Chih-Hsiang Chang, Ying-Fang Lin, Chun Yu Cheng, Sindy Hu
There are versatile modalities to achieve noninvasive fat reduction, and most of them have proven to be effective for circumferential reduction of local fat tissue, without any serious or permanent adverse effects. However, the follow-up time is short, ranging from 1 to 24 weeks. Most of the patients would like to know how long will its effect last and whether there is long-term side effect or not. The aim of this study was to assess the long-term efficacy and safety of combination therapy of focused ultrasound and radio frequency for noninvasive body contouring...
February 2016: Lasers in Medical Science
Monika Chudecka, Anna Lubkowska
The drastic reduction in body weight observed in anorexia nervosa (AN) leads to various endocrine changes and consequently to disturbance in thermoregulation mechanisms and body temperature. Thermography allows for a noninvasive diagnosis of the distribution of skin surface temperatures, which is especially important for difficult patients such as women with AN, who are often very sensitive and difficult to treat. The main aim of this study was to measure the mean temperatures (Tmean ) of selected body areas in young women diagnosed with AN and identify those areas where the temperature differences were particularly significant between healthy women and them...
January 2016: European Eating Disorders Review: the Journal of the Eating Disorders Association
I Copaci, Ioana Lupescu, Elena Caceaune, Grethi Chiriac, G Ismail
UNLABELLED: Nonalcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance and metabolic syndrome, which are linked to obesity. The aim of the study was to assess if weight reduction through 12 months of lifestyle intervention and exercise would lead to improvement of steatosis. METHODS: In a prospective observational study 86 overweight subjects (51 men, 35 women) with steatosis were recruited, after excluding other etiologies. Patients were assigned a caloric goal and a daily fat goal...
January 2015: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
Luana C Cabral, Gustavo L de Carvalho, Rayssa A B de Melo, Fernanda M de Moura, Ana Paula D L Leite
BACKGROUND AND OBJECTIVES: This project is a continuation of a larger project entitled "Treatment with intragastric balloon (IGB) in patients with overweight and obesity in Recife" developed by Professor Dr. Gustavo Lopes de Carvalho. It is a project studying the effectiveness of treatment with IGB evaluating the loss of weight and body mass index and its impact on blood pressure, blood glucose, triglycerides, total cholesterol and fractions. It also assesses the lifestyle of patients studying whether treatment with IGB interferes in smoking, alcohol consumption, eating habits and physical exercises performed by patients...
April 2015: JSLS: Journal of the Society of Laparoendoscopic Surgeons
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