Read by QxMD icon Read

Statistical modeling

Bénédicte Buffin-Meyer, Julie Klein, Benjamin Breuil, Françoise Muller, Panagiotis Moulos, Marion Groussolles, Ourdia Bouali, Jean-Loup Bascands, Stéphane Decramer, Joost P Schanstra
Most of biomarker panels, extracted from single omics traits, still need improvement since they display a gray zone where prediction is uncertain. Here we verified whether a combination of omics traits, fetal urinary metabolites and peptides analyzed in the same sample, improved prediction of postnatal renal function in fetuses with posterior urethral valves (PUV) compared to individual omics traits. Using CE-MS, we explored the urinary metabolome of 13 PUV fetuses with end stage renal disease (ESRD) and 12 PUV fetuses without postnatal ESRD at 2 years postnatally...
June 18, 2018: Journal of Proteomics
Christopher Strouse, Ying Zhang, Mei-Jie Zhang, Alyssa DiGilio, Marcelo Pasquini, Mary M Horowitz, Stephanie Lee, Vincent Ho, Muthalagu Ramanathan, Wichai Chinratanalab, Alison Loren, Linda J Burns, Andrew Artz, Kathleen F Villa, Wael Saber
BACKGROUND: A risk score identifying patients at high risk for veno-occlusive disease (VOD) may aid efforts to study preventive strategies for this uncommon complication of hematopoietic cell transplantation (HCT). METHODS: Patients receiving a first allogeneic HCT between 2008-2013 as reported to the Center for International Blood & Marrow Transplant Research (N=13,097) were randomly divided into training and validation sets. Independent prognostic factors for development of VOD by day+100 post HCT were identified with a multivariate logistic regression model...
June 18, 2018: Biology of Blood and Marrow Transplantation
Carolyn W Swenson, Neil S Kamdar, Kristian Seiler, Daniel M Morgan, Paul Lin, Sawsan As-Sanie
BACKGROUND: Opioids used for postoperative pain control after surgery have been associated with an increased risk of chronic opioid use. Hysterectomy is the most common major gynecologic procedure in the United States; however, we lack a data-driven definition of new persistent opioid use specific to hysterectomy. OBJECTIVE: 1) Determine a data-driven definition of new persistent opioid use among opioid naïve women undergoing hysterectomy; 2) Determine the prevalence of and risk factors for new persistent opioid use...
June 18, 2018: American Journal of Obstetrics and Gynecology
Zhen Hou, Yang Yang, Shuangshuang Li, Jing Yan, Wei Ren, Juan Liu, Kangxin Wang, Baorui Liu, Suiren Wan
Background: To determine the feasibility of radiomic analysis for predicting the therapeutic response of gastric carcinoma (GC) with abdominal cavity metastasis (GCACM) to pulsed low dose rate radiotherapy (PLDRT) using contrast-enhanced computed tomography (CECT) images. Methods: Pretreatment CECT images of 43 GCACM patients were analyzed. Patients with complete response (CR) and partial response (PR) were considered responders, while stable disease (SD) and progressive disease (PD) as non-responders...
May 2018: Quantitative Imaging in Medicine and Surgery
Nantaporn Phatrabuddha, Tanongsak Yingratanasuk, Piti Rotwannasin, Wanlop Jaidee, Narin Krajaiklang
Background: Fatigue and sleepiness are inter-related and common among road transport drivers. In this study, sleep deprivation and fatigue among chemical transportation drivers were examined. Methods: A cross-sectional study surveying 107 drivers from three hazardous types of chemical production and transportation industries (nonflammable gases, flammable gases, and flammable liquids) was conducted. Data on sleep deprivation were collected using questionnaires of the Stanford Sleeping Scale and the Groningen Sleep Quality Scale...
June 2018: Safety and Health At Work
Sona Saksena, Mahdi Alizadeh, Devon M Middleton, Chris J Conklin, Laura Krisa, Adam Flanders, M J Mulcahey, Feroze B Mohamed, Scott H Faro
Study design: Retrospective study. Objectives: To perform quantitative DTI measurements of the entire cervical and thoracic spinal cord (SC) in typically developing (TD) pediatric subjects with incidental findings of syringomyelia or hydromyelia on conventional MRI and in a TD population without any abnormalities. Setting: USA. Methods: 26 TD recruited as part of large SC DTI study, four of these had incidental findings...
2018: Spinal Cord Series and Cases
Tonghu Yu, Huaping Zhang, Hong Qi
The aim of the present study was to investigate more colon cancer-related genes in different stages. Gene expression profile E-GEOD-62932 was extracted for differentially expressed gene (DEG) screening. Series test of cluster analysis was used to obtain significant trending models. Based on the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases, functional and pathway enrichment analysis were processed and a pathway relation network was constructed. Gene co-expression network and gene signal network were constructed for common DEGs...
July 2018: Oncology Letters
Eman Salah
Background: Extragenital warts (E-GWs) are common benign skin lesions caused by human papilloma virus. Surprisingly, there is no clear data about the impact of multiple E-GWs on quality of life in immune-competent adult patients in comparison to GWs, which have been frequently reported to exhibit a strong negative impact on life quality. Patients and methods: This cross-sectional study investigated the impact of multiple E-GWs on quality of life in immune-competent adults as they are more commonly encountered in daily practice than their genital counterpart in the Egyptian population...
2018: Clinical, Cosmetic and Investigational Dermatology
Lukasz Huminiecki
Understanding how regulatory elements control mammalian gene expression is a challenge of post-genomic era. We previously reported that size of proximal promoter architecture predicted the breadth of expression (fraction of tissues in which a gene is expressed). Herein, the contributions of individual transcription factors (TFs) were quantified. Several technologies of statistical modelling were utilized and compared: tree models, generalized linear models (GLMs, without and with regularization), Bayesian GLMs and random forest...
2018: PloS One
Mengyun Cao, Xiaoping Sun, Hai Zhuge
The Semantic Link Network is a general semantic model for modeling the structure and the evolution of complex systems. Various semantic links play different roles in rendering the semantics of complex system. One of the basic semantic links represents cause-effect relation, which plays an important role in representation and understanding. This paper verifies the role of the Semantic Link Network in representing the core of text by investigating the contribution of cause-effect link to representing the core of scientific papers...
2018: PloS One
Yi-Chao Zhou, Wen-Hui Fang, Tung-Wei Kao, Chung-Ching Wang, Yaw-Wen Chang, Tao-Chun Peng, Chen-Jung Wu, Hui-Fang Yang, James Yi-Hsin Chan, Wei-Liang Chen
A growing amount of evidence suggests that thyroid-stimulating hormone (TSH) is associated with cardiometabolic risk. However, there have been few longitudinal studies. The aim of this study was to explore the causal relationship between TSH and metabolic syndrome (MetS) in a large population-based longitudinal study. From 2010 to 2016 at the Health Management Center at Tri-Service General Hospital, 25,121 eligible patients were enrolled in our cross-sectional analyses. Cox proportional hazard models were used to investigate the longitudinal association among hypertension (HTN), prediabetes (pre-DM), MetS, diabetes (DM) and TSH levels (N = 12,463)...
2018: PloS One
Patrick C Eschenfeldt, Uri Kartoun, Curtis R Heberle, Chung Yin Kong, Norman S Nishioka, Kenney Ng, Sagar Kamarthi, Chin Hur
BACKGROUND & AIMS: A common limiting factor in the throughput of gastrointestinal endoscopy units is the availability of space for patients to recover post-procedure. This study sought to identify predictors of abnormally long recovery time after colonoscopy performed with procedural sedation. In clinical research, this type of study would be performed using only one regression modeling approach. A goal of this study was to apply various "machine learning" techniques to see if better prediction could be achieved...
2018: PloS One
Anna Ranta
AIMS: Stroke incidence and mortality are declining due to effective public health initatives and modern healthcare advances. However, due to population growth and ageing, the burden of stroke continues to rise worldwide. This paper aims to provide stroke volume projections for the next 1-2 decades and explores potential solutions to anticipated challenges. METHODS: Health administrative, where available epidemiological, and New Zealand Statistics data was used to model stroke service demand up to 2028...
June 22, 2018: New Zealand Medical Journal
Monik C Jiménez, Lu Wang, Julie E Burnig, JoAnn E Manson, John P Forman, Howard D Sesso
INTRODUCTION: Higher levels of total testosterone and lower levels of sex hormone-binding globulin (SHBG) have been associated with increased blood pressure (BP) in women with an inverse association between total testosterone and BP among men. Fewer studies have examined associations with 24-h ambulatory blood pressure (ABP), blunted nocturnal BP decline or the role of dehydroepiandrosterone sulfate (DHEAS), a precursor to androgens. METHODS: Baseline blood samples were assayed for 229 normotensive men (≥50 years) and women (≥55 years) participating in the VITamin D and OmegA-3 TriaL...
June 20, 2018: Journal of Hypertension
Kjell Vegard Weyde, Norun Hjertager Krog, Bente Oftedal, Per Magnus, Richard White, Stephen Stansfeld, Simon Øverland, Gunn Marit Aasvang
BACKGROUND: Being overweight constitutes a health risk, and the proportion of overweight and obese children is increasing. It has been argued that road traffic noise could be linked to adiposity through its influence on sleep and stress. Few studies, to our knowledge, have investigated whether noise and adiposity are associated. Most of them were on adults, and we are not aware of any longitudinal study using repeated measures. OBJECTIVES: The present longitudinal study investigated whether road traffic noise exposures in pregnancy (N=6,963; obs=22,975) or childhood (N=6,403; obs=14,585) were associated with body mass index (BMI) trajectories in children...
June 20, 2018: Epidemiology
Yubing Zheng, Yang Ma, Lixin Guo, Jianchuan Cheng, Yunlong Zhang
OBJECTIVE: Illegal parking in emergency lanes (paved highway shoulders) is becoming a serious road safety issue in China. The aim of this study was: 1) to examine the utility of the theory of planned behavior (TPB) extended with descriptive norm, past behavior, facilitating and deterring circumstances, sensation seeking and invulnerability in predicting Chinese drivers' intentions in illegal emergency lane parking; 2) to investigate whether respondents' demographic characteristics would impact their views towards the behavior and predictive patterns of intentions; 3) to identify significant predictors of intentions...
June 21, 2018: Traffic Injury Prevention
Pilib Ó Broin, Michael V Beckert, Tomohisa Takahashi, Takeshi Izumi, Kenny Ye, Gina Kang, Patricia Pouso, Mackenzie Topolski, Jose L Pena, Noboru Hiroi
Neonatal vocalization is structurally altered in mouse models of autism spectrum disorder (ASD). Our published data showed that pup vocalization, under conditions of maternal separation, contains sequences whose alterations in a genetic mouse model of ASD impair social communication between pups and mothers. We describe details of a method which reveals the statistical structure of call sequences that are functionally critical for optimal maternal care. Entropy analysis determines the degree of non-random call sequencing...
June 2018: Current Protocols in Mouse Biology
A N Simonov, T P Klyushnik, L V Androsova, N M Mikhaylova
AIM: To quantify the relationship of Alzheimer's disease with the inflammatory markers: enzymatic activity of leukocyte elastase (LE) and functional activity of α1-proteinase inhibitor (α1-PI) on the basis of the logistic regression model and to build a model to predict the probability of AD in patients with mild cognitive impairment (MCI). MATERIAL AND METHODS: The object of the mathematical analysis was the database, which included the results of assays of LE activity and functional α1-PI activity in blood plasma of 91 patients with a verified diagnosis of AD in inpatient or outpatient treatment and 37 age-matched healthy people...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Xiao-Xuan Jia, Yi Wang, Jin Cheng, Xun Yao, Mu-Jun Yin, Jing Zhou, Ying-Jiang Ye
OBJECTIVE: The objective of this study was to compare the prognoses of patients with low- and high-risk rectal cancer detected by MRI who were treated without neoadjuvant chemoradiotherapy (NCRT) and to determine independent risk factors. MATERIALS AND METHODS: This retrospective study included 185 patients with pathologically proven rectal adenocarcinoma who were treated without NCRT. Cancer was defined as high risk if one or more of the following factors were present: extramural depth of tumor invasion greater than 5 mm or stage T4a or T4b for tumor in the mid or high rectum; involvement of intersphincteric space, levators, or adjacent organs for tumor in the low rectum; extramural venous invasion (EMVI); or circumferential resection margin (CRM) involvement...
June 21, 2018: AJR. American Journal of Roentgenology
Jacqueline Liggett, Martin Sellbom
The current study evaluated the continuity between the diagnostic operationalizations of obsessive-compulsive personality disorder (OCPD) in the Diagnostic and Statistical Manual for Mental Disorders, Fifth Edition, both as traditionally operationalized and from the perspective of the alternative model of personality disorders. Using both self-report and informant measures, the study had the following four aims: (a) to examine the extent to which self-report and informant data correspond, (b) to investigate whether both self-report and informant measures of the alternative model of OCPD can predict traditional OCPD, (c) to determine if any traits additional to those proposed in the alternative model of OCPD can predict traditional OCPD, and (d) to investigate whether a measure of OCPD-specific impairment is better at predicting traditional OCPD than are measures of general impairment in personality functioning...
June 21, 2018: Personality Disorders
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"