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Statistical modeling

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https://www.readbyqxmd.com/read/28445963/genetic-polymorphisms-of-bcl-2-promoter-in-cancer-susceptibility-and-prognosis-a-meta-analysis
#1
Zhongqiang Yao, Binhui Yang, Zhongqiu Liu, Wei Li, Qihua He, Xingchun Peng
Bcl-2 is critical for tumorigenesis. However, previous studies on the association of Bcl-2 promoter polymorphisms with predisposition to different cancer types are somewhat contradictory. Therefore, we performed this meta-analysis regarding the relationship between Bcl-2 promoter single nucleotide polymorphisms (SNPs) and cancer susceptibility and prognosis. Up to August 2016, 32 original publications were identified covering two Bcl-2 promoter SNPs (rs2279115 and rs1801018). Our results showed statistically significant association between rs2279115 and cancer susceptibility and prognosis in all four genetic models but not in rs1801018...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28445797/development-of-a-clinically-actionable-incisional-hernia-risk-model-after-colectomy-using-the-healthcare-cost-and-utilization-project
#2
Jason M Weissler, Michael A Lanni, Jesse Y Hsu, Michael G Tecce, Martin J Carney, Rachel R Kelz, Justin P Fox, John P Fischer
BACKGROUND: Incisional hernia (IH) remains a persistent and burdensome complication following colectomy. Through individualized risk-assessment and prediction models, we aim to: 1) improve preoperative risk counseling for patients undergoing colectomy; 2) identify modifiable preoperative risk factors; and 3) encourage the utilization of evidence-based risk prediction instruments in the clinical setting. STUDY DESIGN: A retrospective review of the Healthcare Cost and Utilization Project (HCUP) data was conducted for all patients undergoing either open or laparoscopic colectomy as identified through the state inpatient databases (SID) of California, Florida and New York in 2009...
April 23, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28445775/changes-in-social-isolation-and-loneliness-following-total-hip-and-knee-arthroplasty-longitudinal-analysis-of-the-english-longitudinal-study-of-ageing-elsa-cohort
#3
Toby O Smith, Jack R Dainty, Alex Macgregor
OBJECTIVE: To determine the prevalence and change in social isolation and loneliness in people before and after THA and TKA in England. DESIGN: The English Longitudinal Study of Ageing dataset, a prospective study of community-dwelling older adults, was used to identify people who had undergone primary THA or TKA because of osteoarthritis. Social isolation was assessed using the ELSA Social Isolation Index. Loneliness was evaluated using the Revised University of California, Los Angeles (UCLA) Loneliness Scale...
April 23, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28445749/equilibrium-ensembles-for-insulin-folding-from-bias-exchange-metadynamics
#4
Richa Singh, Rohit Bansal, Anurag Singh Rathore, Gaurav Goel
Earliest events in the aggregation process, such as single molecule reconfiguration, are extremely important and the most difficult to characterize in experiments. To this end, we have used well-tempered bias exchange metadynamics simulations to determine the equilibrium ensembles of an insulin molecule under amyloidogenic conditions of low pH and high temperature. A bin-based clustering method that uses statistics accumulated in bias exchange metadynamics trajectories was employed to construct a detailed thermodynamic and kinetic model of insulin folding...
April 25, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28445746/crosstalk-and-the-dynamical-modularity-of%C3%A2-feed-forward-loops-in-transcriptional-regulatory-networks
#5
Michael A Rowland, Ahmed Abdelzaher, Preetam Ghosh, Michael L Mayo
Network motifs, such as the feed-forward loop (FFL), introduce a range of complex behaviors to transcriptional regulatory networks, yet such properties are typically determined from their isolated study. We characterize the effects of crosstalk on FFL dynamics by modeling the cross regulation between two different FFLs and evaluate the extent to which these patterns occur in vivo. Analytical modeling suggests that crosstalk should overwhelmingly affect individual protein-expression dynamics. Counter to this expectation we find that entire FFLs are more likely than expected to resist the effects of crosstalk (≈20% for one crosstalk interaction) and remain dynamically modular...
April 25, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28445711/the-short-term-behavioural-response-of-sows-but-not-gilts-to-a-social-stimulus-is-related-to-sow-aggressiveness-in-groups
#6
M Verdon, R S Morrison, M Rice, K L Butler, P H Hemsworth
This study examined relationships between the behavioural response of pregnant gilts (n=200, gestation 1) and sows (n=200, gestation 2) to a live, similarly-aged female pig (unfamiliar pig test, UPT) and to a fibre-glass model pig (model pig test, MPT), and aggressive behaviour on the day after mixing (day 2). Sows with a short latency to make contact with an unfamiliar sow in the UPT were more likely to deliver high levels of aggression at day 2 of gestation 2 (P=0.005), but this relationship was stronger when a model pig was used (P <0...
April 23, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28445696/which-factors-affect-citation-rates-in-the-oral-and-maxillofacial-surgery-literature
#7
Kristie Cheng, Thomas B Dodson, Mark A Egbert, Srinivas M Susarla
PURPOSE: Citation rate is one of several tools to measure academic productivity. The purposes of this study were to estimate and identify factors associated with citation rates in the oral and maxillofacial surgery (OMS) literature. MATERIALS AND METHODS: This was a retrospective longitudinal study of publications in the Journal of Oral and Maxillofacial Surgery (JOMS), International Journal of Oral and Maxillofacial Surgery (IJOMS), and Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology from January through December 2012...
April 1, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28445550/classifying-patents-based-on-their-semantic-content
#8
Antonin Bergeaud, Yoann Potiron, Juste Raimbault
In this paper, we extend some usual techniques of classification resulting from a large-scale data-mining and network approach. This new technology, which in particular is designed to be suitable to big data, is used to construct an open consolidated database from raw data on 4 million patents taken from the US patent office from 1976 onward. To build the pattern network, not only do we look at each patent title, but we also examine their full abstract and extract the relevant keywords accordingly. We refer to this classification as semantic approach in contrast with the more common technological approach which consists in taking the topology when considering US Patent office technological classes...
2017: PloS One
https://www.readbyqxmd.com/read/28445508/error-model-of-geomagnetic-field-measurement-and-extended-kalman-filter-based-compensation-method
#9
Zhilei Ge, Suyun Liu, Guopeng Li, Yan Huang, Yanni Wang
The real-time accurate measurement of the geomagnetic-field is the foundation to achieving high-precision geomagnetic navigation. The existing geomagnetic-field measurement models are essentially simplified models that cannot accurately describe the sources of measurement error. This paper, on the basis of systematically analyzing the source of geomagnetic-field measurement error, built a complete measurement model, into which the previously unconsidered geomagnetic daily variation field was introduced. This paper proposed an extended Kalman-filter based compensation method, which allows a large amount of measurement data to be used in estimating parameters to obtain the optimal solution in the sense of statistics...
2017: PloS One
https://www.readbyqxmd.com/read/28445430/impact-of-land-use-on-pm2-5-pollution-in-a-representative-city-of-middle-china
#10
Haiou Yang, Wenbo Chen, Zhaofeng Liang
Fine particulate matter (PM2.5) pollution has become one of the greatest urban issues in China. Studies have shown that PM2.5 pollution is strongly related to the land use pattern at the micro-scale and optimizing the land use pattern has been suggested as an approach to mitigate PM2.5 pollution. However, there are only a few researches analyzing the effect of land use on PM2.5 pollution. This paper employed land use regression (LUR) models and statistical analysis to explore the effect of land use on PM2.5 pollution in urban areas...
April 26, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28445362/effect-of-human-fat-graft-on-breast-cancer-metastasis-in-a-murine-model
#11
Roberto Moltó-García, Virina González-Alonso, María Eloísa Villaverde-Doménech, Edurne Novella-Maestre
BACKGROUND: Isolated adipose stem cells have been reported to encourage migration and early metastasis of breast cancer. Mimicking a surgical situation, the authors developed a human breast cancer model to evaluate in vivo whether human adipose tissue promotes tumor growth and invasion. METHODS: Human adipose tissue was obtained from four patients. The MDA-MB-468 cell line was cultured with a lentiviral vector encoding a puromycin resistance gene and mCherry fluorescent protein...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28445354/a-prospective-randomized-trial-comparing-the-effects-of-lidocaine-in-breast-reduction-surgery
#12
Brian M Christie, Sahil Kapur, Steve J Kempton, Summer E Hanson, Yue Ma, Venkat K Rao
BACKGROUND: Use of dilute epinephrine tumescent solution in breast reduction surgery has been shown to significantly decrease operative blood loss without increasing perioperative complications. Lidocaine is commonly added to epinephrine to decrease postoperative pain. Evidence supporting this practice, however, is limited, and lidocaine toxicity has been reported. METHODS: With institutional review board approval, patients undergoing bilateral breast reduction surgery were assigned to receive either tumescent saline solution with epinephrine (1:1 million) (group 1), or tumescent saline solution with epinephrine (1:1 million) and lidocaine (0...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28445289/vitamin-k-intake-and-the-risk-of-fractures-a-meta-analysis
#13
Guangliang Hao, Bei Zhang, Mingyong Gu, Chen Chen, Qiang Zhang, Guichun Zhang, Xuecheng Cao
The association between dietary vitamin K intake and the risk of fractures is controversial. Therefore we perform a meta-analysis of cohort or nested case-control studies to investigate the relationship between dietary vitamin K intake and the risk of fractures. A comprehensive search of PubMed and EMBASE (to July 11, 2016) was performed to identify cohort or nested case-control studies providing quantitative estimates between dietary vitamin K intake and the risk of fractures. Summary relative risk (RRs) with corresponding 95% confidence intervals (CIs) were pooled by using a random-effects model...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28445196/the-use-of-a-fresh-tissue-cadaver-model-for-the-instruction-of-dermatological-procedures-a-laboratory-study-for-training-medical-students
#14
Jose A Cervantes, Collin M Costello, Melody Maarouf, Hilary C McCrary, Nathalie C Zeitouni
BACKGROUND: A realistic model for the instruction of basic dermatologic procedural skills was developed, while simultaneously increasing medical student exposure to the field of dermatology. OBJECTIVE: The primary purpose of the authors' study was to evaluate the utilization of a fresh-tissue cadaver model (FTCM) as a method for the instruction of common dermatologic procedures. The authors' secondary aim was to assess students' perceived clinical skills and overall perception of the field of dermatology after the lab...
April 24, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28444799/pixel-wise-estimation-of-noise-statistics-on-iterative-ct-reconstruction-from-a-single-scan
#15
Tonghe Wang, Lei Zhu
PURPOSE: As iterative CT reconstruction continues to advance, the spatial distribution of noise standard deviation (STD) and accurate noise power spectrum (NPS) on the reconstructed CT images become important for method evaluation as well as optimization of algorithm parameters. Using a single CT scan, we propose a practical method for pixel-wise calculation of noise statistics on an iteratively reconstructed CT image, which enables accurate calculation of noise STD for each pixel and NPS...
April 26, 2017: Medical Physics
https://www.readbyqxmd.com/read/28444506/preoperative-risk-factors-for-prolonged-postoperative-ileus-after-colorectal-resection
#16
Albert M Wolthuis, Gabriele Bislenghi, Maarten Lambrecht, Steffen Fieuws, Anthony de Buck van Overstraeten, Guy Boeckxstaens, André D'Hoore
PURPOSE: Prolonged postoperative ileus (PPOI) after colorectal resection significantly impacts patients' recovery and hospital stay. Because treatment options for PPOI are limited, it is necessary to focus on prevention strategies. The aim of this study is to investigate risk factors associated with PPOI in patients undergoing colorectal surgery. METHODS: Data from all consecutive patients who underwent colorectal resection in our department were retrospectively analyzed from a prospective database over a 9-month period...
April 25, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28444503/comparative-evaluation-of-the-algorithms-for-parametric-mapping-of-the-novel-myocardial-pet-imaging-agent-18-f-fptp
#17
Ji Who Kim, Seongho Seo, Hyeon Sik Kim, Dong-Yeon Kim, Ho-Young Lee, Keon Wook Kang, Dong Soo Lee, Hee-Seung Bom, Jung-Joon Min, Jae Sung Lee
OBJECTIVE: ((18)F-fluoropentyl)triphenylphosphonium salt ((18)F-FPTP) is a new promising myocardial PET imaging tracer. It shows high accumulation in cardiomyocytes and rapid clearance from liver. We performed compartmental analysis of (18)F-FPTP PET images in rat and evaluated two linear analyses: linear least-squares (LLS) and a basis function method (BFM) for generating parametric images. The minimum dynamic scan duration for kinetic analysis was also investigated and computer simulation undertaken...
April 25, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28444496/incidence-of-incisional-hernia-in-the-specimen-extraction-site-for-laparoscopic-colorectal-surgery-systematic-review-and-meta-analysis
#18
Lawrence Lee, Maria Abou-Khalil, Sender Liberman, Marylise Boutros, Gerald M Fried, Liane S Feldman
INTRODUCTION: The incidence of incisional hernia(IH) may be affected by the choice of specimen extraction incision. The objective of this study was to perform a systematic review and meta-analysis comparing the incidence of IH after midline and off-midline incisions in patients undergoing laparoscopic colorectal surgery. METHODS: A systematic search was performed according to PRISMA guidelines to identify all comparative studies from January 1991-August 2016 on the incidence of IH after midline and off-midline(transverse or Pfannenstiel) incisions in patients undergoing laparoscopic colorectal surgery...
April 25, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28444468/a-new-statistical-model-for-analyzing-rating-scale-data-pertaining-to-word-meaning
#19
Felipe Munoz-Rubke, Karen Kafadar, Karin H James
The concrete-abstract categorization scheme has guided several research programs. A popular way to classify words into one of these categories is to calculate a word's mean value in a Concreteness or Imageability rating scale. However, this procedure has several limitations. For instance, results can be highly distorted by outliers, ascribe differences among words when none may exist, and neglect rating trends in participants. We suggest using an alternative procedure to analyze rating scale data called median polish analysis (MPA)...
April 25, 2017: Psychological Research
https://www.readbyqxmd.com/read/28444438/effect-and-safety-of-early-weight-bearing-on-the-outcome-after-open-wedge-high-tibial-osteotomy-a-systematic-review-and-meta-analysis
#20
O-Sung Lee, Soyeon Ahn, Yong Seuk Lee
INTRODUCTION: The purpose of this systematic review and meta-analysis was to evaluate the effectiveness and safety of early weight-bearing by comparing clinical and radiological outcomes between early and traditional delayed weight-bearing after OWHTO. MATERIALS AND METHODS: A rigorous and systematic approach was used. The methodological quality was also assessed. Results that are possible to be compared in two or more than two articles were presented as forest plots...
April 25, 2017: Archives of Orthopaedic and Trauma Surgery
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