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https://www.readbyqxmd.com/read/27899589/through-bond-effects-in-the-ternary-complexes-of-thrombin-sandwiched-by-two-dna-aptamers
#1
Andrea Pica, Irene Russo Krauss, Valeria Parente, Hisae Tateishi-Karimata, Satoru Nagatoishi, Kouhei Tsumoto, Naoki Sugimoto, Filomena Sica
Aptamers directed against human thrombin can selectively bind to two different exosites on the protein surface. The simultaneous use of two DNA aptamers, HD1 and HD22, directed to exosite I and exosite II respectively, is a very powerful approach to exploit their combined affinity. Indeed, strategies to link HD1 and HD22 together have been proposed in order to create a single bivalent molecule with an enhanced ability to control thrombin activity. In this work, the crystal structures of two ternary complexes, in which thrombin is sandwiched between two DNA aptamers, are presented and discussed...
November 28, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27885534/zinc-deficiency-after-gastric-bypass-for-morbid-obesity-a-systematic-review
#2
REVIEW
Kamal K Mahawar, Aparna Govil Bhasker, Vivek Bindal, Yitka Graham, Usha Dudeja, Muffazal Lakdawala, Peter K Small
Up to 50% of patients have zinc deficiency before bariatric surgery. Roux-en-Y gastric bypass (RYGB) is the commonest bariatric procedure worldwide. It can further exacerbate zinc deficiency by reducing intake as well as absorption. The British Obesity and Metabolic Surgery Society, therefore, recommends that zinc level should be monitored routinely following gastric bypass. However, the American guidance does not recommend such monitoring for all RYGB patients and reserves it for patients with 'specific findings'...
November 24, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27869412/blood-lead-levels-in-children-aged-between-1-and-6-years-old-in-la-plata-argentina-identification-of-risk-factors-for-lead-exposure
#3
Enrique Martins, Ana Varea, Karina Hernández, Marisa Sala, Ana Girardelli, Victoria Fasano, Liliana Disalvo
INTRODUCTION: Lead has neurotoxic effects in children, even at a very low level in blood. The risk factors (RFs) for lead exposure have not been adequately identified in La Plata. The objectives of this study were to determine mean blood lead levels and identify RFs in children aged 1 to 6 years old living in La Plata and the outskirts. POPULATION AND METHODS: A cross-sectional study was conducted in children who attended primary health care centers for a health check-up...
December 1, 2016: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/27865050/nmr-spectroscopic-assignment-of-backbone-and-side-chain-protons-in-fully-protonated-proteins-microcrystals-sedimented-assemblies-and-amyloid-fibrils
#4
Jan Stanek, Loren B Andreas, Kristaps Jaudzems, Diane Cala, Daniela Lalli, Andrea Bertarello, Tobias Schubeis, Inara Akopjana, Svetlana Kotelovica, Kaspars Tars, Andrea Pica, Serena Leone, Delia Picone, Zhi-Qiang Xu, Nicholas E Dixon, Denis Martinez, Mélanie Berbon, Nadia El Mammeri, Abdelmajid Noubhani, Sven Saupe, Birgit Habenstein, Antoine Loquet, Guido Pintacuda
We demonstrate sensitive detection of alpha protons of fully protonated proteins by solid-state NMR spectroscopy with 100-111 kHz magic-angle spinning (MAS). The excellent resolution in the Cα-Hα plane is demonstrated for 5 proteins, including microcrystals, a sedimented complex, a capsid and amyloid fibrils. A set of 3D spectra based on a Cα-Hα detection block was developed and applied for the sequence-specific backbone and aliphatic side-chain resonance assignment using only 500 μg of sample. These developments accelerate structural studies of biomolecular assemblies available in submilligram quantities without the need of protein deuteration...
November 16, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27837451/percutaneous-image-guided-cryoablation-current-applications-and-results-in-the-oncologic-field
#5
Roberto Luigi Cazzato, Julien Garnon, Nitin Ramamurthy, Guillaume Koch, Georgia Tsoumakidou, Jean Caudrelier, Francesco Arrigoni, Luigi Zugaro, Antonio Barile, Carlo Masciocchi, Afshin Gangi
Percutaneous imaging-guided cryoablation (PICA) is a recently developed technique, which applies extreme hypothermia to destroy tumours under close imaging surveillance. It is minimally invasive, safe, repeatable, and does not interrupt or compromise other oncologic therapies. It presents several advantages over more established heat-based thermal ablation techniques (e.g. radiofrequency ablation; RFA) including intrinsic analgesic properties, superior monitoring capability on multi-modal imaging, ability to treat larger tumours, and preservation of tissue collagenous architecture...
December 2016: Medical Oncology
https://www.readbyqxmd.com/read/27823991/quadrupole-shift-of-nuclear-magnetic-resonance-of-donors-in-silicon-at-low-magnetic-field
#6
P A Mortemousque, S Rosenius, G Pica, D P Franke, T Sekiguchi, A Truong, M P Vlasenko, L S Vlasenko, M S Brandt, R G Elliman, K M Itoh
Shifts from the expected nuclear magnetic resonance frequencies of antimony and bismuth donors in silicon of greater than a megahertz are observed in electrically detected magnetic resonance spectra. Defects created by ion implantation of the donors are discussed as the source of effective electric field gradients generating these shifts via quadrupole interaction with the nuclear spins. The experimental results are modeled quantitatively by molecular orbital theory for a coupled pair consisting of a donor and a spin-dependent recombination readout center...
November 8, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27814312/impact-of-artifacts-on-vor-gain-measures-by-video-oculography-in-the-acute-vestibular-syndrome
#7
Georgios Mantokoudis, Ali S Saber Tehrani, Amy Wozniak, Karin Eibenberger, Jorge C Kattah, Cynthia I Guede, David S Zee, David E Newman-Toker
OBJECTIVE: The video head impulse test (HIT) measures vestibular function (vestibulo-ocular reflex [VOR] gain - ratio of eye to head movement), and, in principle, could be used to make a distinction between central and peripheral causes of vertigo. However, VOG recordings contain artifacts, so using unfiltered device data might bias the final diagnosis, limiting application in frontline healthcare settings such as the emergency department (ED). We sought to assess whether unfiltered data (containing artifacts) from a video-oculography (VOG) device have an impact on VOR gain measures in acute vestibular syndrome (AVS)...
November 3, 2016: Journal of Vestibular Research: Equilibrium & Orientation
https://www.readbyqxmd.com/read/27793767/ruptured-distal-posterior-inferior-cerebellar-artery-pica-aneurysms-associated-with-cerebellar-arterial-venous-malformations-avms-a-case-series-and-review-of-the-literature-demonstrating-the-need-for-angiographic-evaluation-and-feasibility-of-endovascular-treatment
#8
David Case, David Kumpe, Luis Cava, Robert Neumann, Andrew White, Christopher Roark, Joshua Seinfeld
OBJECTIVE: The characteristics, diagnosis, and preferred management strategies for distal posterior inferior cerebellar artery (PICA) aneurysms associated with cerebellar arteriovenous malformation (AVMs) are poorly understood. We present a case series with attention to aneurysm angioarchitecture, diagnostic imaging, treatment approaches, and a thorough review of the literature. With this information, we demonstrate a specific anatomical pattern for these aneurysms, an underreported need for conventional digital subtraction angiography (DSA) during evaluation, along with the utility of endovascular treatment with liquid embolic agents...
October 25, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27766499/arteries-and-veins-of-the-cerebellum
#9
Matthieu Delion, Mickael Dinomais, Philippe Mercier
Surgery of the posterior fossa represents a technical challenge because of the proximity of the vessels of the cerebellum. If the arterial vascularization of the cerebellum is well known, the main arterial variations and the whole venous vascularization are probably under recognized. We describe the vascular organization and the main variations through photographs of colored latex perfused brains, obtained with a surgical microscope. The arterial vascularization of the cerebellum is based on three arteries which all originate from the vertebrobasilar system: the superior cerebellar artery (SCA), the anterior and inferior cerebellar artery (AICA), and the posterior and inferior cerebellar artery (PICA)...
October 20, 2016: Cerebellum
https://www.readbyqxmd.com/read/27762120/sudden-simultaneous-cerebellar-infarction-in-the-territories-of-the-medial-division-of-posterior-inferior-cerebellar-arteries
#10
K Mugundhan, Rajesh Shankar Iyer
Strokes involving posterior inferior cerebellar arteries (PICA) are rare and usually unilateral. They can involve either the lateral division or the medial division of PICA. Sudden simultaneous cerebellar infarctions in the medial PICA territories are extremely rare. We report one such patient who presented with acute bilateral cerebellar infarctions in the medial PICA territories. She was a diabetic and had features of diffuse atherosclerotic vertebrobasilar disease. We discuss the anatomical peculiarities of PICA and its blood supply along with the clinical features differentiating the medial and lateral PICA infarctions...
August 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27722309/an-alternative-explanation-of-the-cononsolvency-of-poly-n-isopropylacrylamide-in-water-methanol-solutions
#11
Andrea Pica, Giuseppe Graziano
Cononsolvency refers to the experimental finding that poly(N-isopropylacrylamide), PNIPAM, has a coil conformation in both pure water and pure methanol, at 20 °C and 1 atm, but assumes a globule conformation in methanol-water solutions, over the 0.1 ≤ X(MeOH) ≤ 0.4 methanol molar fraction. This strange phenomenon has recently been rationalized by claiming that: (a) MeOH molecules are able to bind two distant monomers in the chain, driving collapse [Nat. Commun., 2014, 5, 4882]; (b) the preferential binding of MeOH stabilizes globule conformations due to a conformational entropy gain of the chain [J...
September 14, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27718027/safety-and-efficacy-of-treatment-strategies-for-posterior-inferior-cerebellar-artery-aneurysms-a-systematic-review-and-meta-analysis
#12
Ondra Petr, Alena Sejkorová, Ondřej Bradáč, Waleed Brinjikji, Giuseppe Lanzino
INTRODUCTION: We conducted a systematic review of the literature to evaluate the safety and efficacy of treatment strategies for PICA aneurysms. METHODS: A systematic search of Medline, EMBASE, Scopus, and Web of Science was done for studies published through November 2015. We included studies that described treatment of PICA aneurysms with ≥10 patients. Random-effects meta-analysis was used to pool the following outcomes: complete occlusion, technical success, periprocedural morbidity/mortality, stroke rates, aneurysm recurrence/rebleed, CN palsies rates, and long-term neurological morbidity/mortality...
October 7, 2016: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27702826/training-programs-on-endoscopic-scoring-systems-for-inflammatory-bowel-disease-lead-to-a-significant-increase-in-interobserver-agreement-among-community-gastroenterologists
#13
Marco Daperno, Michele Comberlato, Fabrizio Bossa, Alessandro Armuzzi, Livia Biancone, Andrea G Bonanomi, Rocco Cosintino, Giovanni Lombardi, Roberto Mangiarotti, Alfredo Papa, Roberta Pica, Luca Grassano, Guido Pagana, Renata D'Incà, Ambrogio Orlando, Fernando Rizzello
BACKGROUNDS AND AIMS: Endoscopic outcomes are increasingly used in clinical trials and in routine practice for inflammatory bowel disease [IBD] in order to reach more objective patient evaluations than possible using only clinical features. However, reproducibility of endoscopic scoring systems used to categorize endoscopic activity has been reported to be suboptimal.The aim of this study was to analyse the inter-rated agreement of non-dedicated gastroenterologists on IBD endoscopic scoring systems, and to explore the effects of a dedicated training programme on agreement...
October 4, 2016: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/27701928/pica-as-a-manifestation-of-iron-deficiency
#14
Caterina Borgna-Pignatti, Sara Zanella
Pica is the compulsive eating of non-nutritive substances. It is often associated with iron deficiency but its pathophysiology is unknown. Areas covered: We searched the literature using the keywords listed below. Our aim was to describe the phenomenon in its various aspects, to touch briefly on the historical and cultural background, and to examine in more detail the studies that tried to analyze the relative roles of iron deficiency and pica. Expert commentary: Pica is an intriguing symptom known for centuries...
November 2016: Expert Review of Hematology
https://www.readbyqxmd.com/read/27696421/response-of-saliva-na-k-ratio-to-changing-na-supply-of-lactating-cows-under-tropical-conditions
#15
Wandee Thiangtum, J Thomas Schonewille, Martin Wa Verstegen, Supot Arsawakulsudhi, Theera Rukkwamsuk, Wouter H Hendriks
BACKGROUND: Factorial determination of the sodium (Na) requirement of heat-stressed lactating cows is hindered by accurate estimates of the Na losses through sweat. Direct studies, therefore, may be needed requiring information on the time course of healthy animals to become Na depleted and the subsequent rate of repletion. The rate of Na depletion and subsequent rate of Na repletion with two levels of dietary Na to lactating dairy cows housed under tropical conditions were investigated using the salivary Na/K...
October 3, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27696359/pica-in-rats-as-a-preclinical-model-of-emesis
#16
T Gregg Davis
The ability to assess the potential for gastrointestinal adverse events in a preclinical setting is a challenge in the development of new drugs, as the vast majority of in vivo research is conducted in rodent species lacking a vomiting reflex. The use of higher species capable of emesis is often limited by cost, technical experience, and relevant efficacy models to define a therapeutic index. Additionally, investigators should be mindful of ethical considerations when using more sentient species when an alternative in lower species is available...
October 3, 2016: Current Protocols in Neuroscience
https://www.readbyqxmd.com/read/27658853/sweeter-and-stronger-enhancing-sweetness-and-stability-of-the-single-chain-monellin-mnei-through-molecular-design
#17
Serena Leone, Andrea Pica, Antonello Merlino, Filomena Sannino, Piero Andrea Temussi, Delia Picone
Sweet proteins are a family of proteins with no structure or sequence homology, able to elicit a sweet sensation in humans through their interaction with the dimeric T1R2-T1R3 sweet receptor. In particular, monellin and its single chain derivative (MNEI) are among the sweetest proteins known to men. Starting from a careful analysis of the surface electrostatic potentials, we have designed new mutants of MNEI with enhanced sweetness. Then, we have included in the most promising variant the stabilising mutation E23Q, obtaining a construct with enhanced performances, which combines extreme sweetness to high, pH-independent, thermal stability...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27651870/bioglue-coated-teflon-sling-technique-in-microvascular-decompression-for-hemifacial-spasm-involving-the-vertebral-artery
#18
Seong Ho Lee, Jae Sung Park, Young Hwan Ahn
OBJECTIVE: Microvascular decompression (MVD) for hemifacial spasm (HFS) involving the vertebral artery (VA) can be technically challenging. We investigated the therapeutic effects of a bioglue-coated Teflon sling technique on the VA during MVD in 42 cases. METHODS: A bioglue-coated Teflon sling was crafted by the surgeon and applied to patients in whom neurovascular compression was caused by the VA. The radiologic data, intra-operative findings with detailed introduction of the procedure, and the clinical outcomes of each patient were reviewed and analyzed...
September 2016: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/27642435/anaemia-in-pregnant-adolescent-girls-with-malaria-and-practicing-pica
#19
Freda Dzifa Intiful, Edwin Kwame Wiredu, George Awuku Asare, Matilda Asante, David Nana Adjei
INTRODUCTION: Pregnancy during the adolescent period is challenging mainly because of the nutritional demands of both the adolescent and pregnancy period. The risk for anaemia increases especially in developing countries such as Ghana where malaria is endemic and the practice of pica is common. In this study, we sought to determine the prevalence of anaemia, pica practice and malaria infection among pregnant adolescent girls and assess the extent to which these factors are associated...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27637630/surgical-treatment-of-complex-cerebral-aneurysms-using-interposition-short-vein-graft
#20
Yasuhiko Kaku, Hiroaki Takei, Masafumi Miyai, Kentarou Yamashita, Jouji Kokuzawa
BACKGROUND AND AIMS: Cerebral revascularization strategies may become necessary in select patients who present with challenging cerebral aneurysms. In this study, we present the techniques of a moderate-flow extra-intracranial bypass using a short interposition vein graft and concurrent aneurysm management. METHODS: The short interposition vein graft was used for the reconstruction of complex cerebral aneurysms in nine patients. In eight of them, the superficial temporal artery (STA) main trunk was used as a donor site for the anastomosis of a short interposition vein graft, and an extracranial vertebral artery (VA) was used in one case...
2016: Acta Neurochirurgica. Supplement
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