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https://www.readbyqxmd.com/read/28647997/-endovascular-management-and-classification-of-the-dissecting-aneurysms-of-the-vertebral-artery
#1
Y Z Zang, Z G Wang, C W Wang, X Ding, X F Wang, L L Wang
Objective: To summarize the classifications and optimize endovascular treatment of the dissecting aneurysms of the vertebral artery (DAVA). Methods: The clinical information of 39 cases of DAVA treated with endovascular methods in our department between January 2007 and September 2016 were analyzed retrospectively.According to the location of the aneurysm in relation to the posterior inferior cerebellar artery (PICA), the aneurysms were classified into three types: type pre-PICA, located proximally to the PICA; type in-PICA, located at the PICA origin; and type post-PICA located distally to the PICA...
June 20, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28647450/central-administration-of-ghrelin-induces-conditioned-avoidance-in-rodents
#2
Erik Schéle, Christopher Cook, Marie Le May, Tina Bake, Simon M Luckman, Suzanne L Dickson
Feelings of hunger carry a negative-valence (emotion) signal that appears to be conveyed through agouti-related peptide (AgRP) neurons in the hypothalamic arcuate nucleus. The circulating hunger hormone, ghrelin, activates these neurons although it remains unclear whether it also carries a negative-valence signal. Given that ghrelin also activates pathways in the midbrain that are important for reward, it remains possible that ghrelin could act as a positive reinforcer and hence, carry a positive-valence signal...
June 21, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28639505/rationale-and-design-of-the-multiethnic-pharmacogenomics-in-childhood-asthma-consortium
#3
Niloufar Farzan, Susanne J Vijverberg, Anand K Andiappan, Lambang Arianto, Vojko Berce, Natalia Blanca-López, Hans Bisgaard, Klaus Bønnelykke, Esteban G Burchard, Paloma Campo, Glorisa Canino, Bruce Carleton, Juan C Celedón, Fook Tim Chew, Wen Chin Chiang, Michelle M Cloutier, Denis Daley, Herman T Den Dekker, Nicole F Dijk, Liesbeth Duijts, Carlos Flores, Erick Forno, Daniel B Hawcutt, Natalia Hernandez-Pacheco, Johan C de Jongste, Michael Kabesch, Gerard H Koppelman, Vangelis G Manolopoulos, Erik Melén, Somnath Mukhopadhyay, Sara Nilsson, Colin N Palmer, Maria Pino-Yanes, Munir Pirmohamed, Uros Potočnki, Jan A Raaijmakers, Katja Repnik, Maximilian Schieck, Yang Yie Sio, Rosalind L Smyth, Csaba Szalai, Kelan G Tantisira, Steve Turner, Marc P van der Schee, Katia M Verhamme, Anke H Maitland-van der Zee
AIM: International collaboration is needed to enable large-scale pharmacogenomics studies in childhood asthma. Here, we describe the design of the Pharmacogenomics in Childhood Asthma (PiCA) consortium. MATERIALS & METHODS: Investigators of each study participating in PiCA provided data on the study characteristics by answering an online questionnaire. RESULTS: A total of 21 studies, including 14,227 children/young persons (58% male), from 12 different countries are currently enrolled in the PiCA consortium...
June 22, 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28632074/isopropyl-alcohol-swabs-as-a-preferred-substance-of-abuse
#4
Aditi Sharma, Jonathan D Morrow
The authors describe the treatment of a 36-year-old woman who presented with excessive consumption of antiseptic alcohol swabs. Her behavior was diagnosed as a severe substance use disorder with isopropyl alcohol as the primary drug of choice. Diagnostic and treatment challenges involved in the case are discussed in detail, with particular focus on the differential diagnosis for this unusual presentation, including obsessive compulsive disorder, pica, and intentional self-injurious behavior. A brief review of the literature on non-ethanol ingestion for the purposes of intoxication is included, as well as clinical information about the potential dangers posed by isopropyl alcohol consumption...
February 26, 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/28627000/pencil-beam-scanned-protons-for-the-treatment-of-patients-with-ewing-sarcoma
#5
Damien C Weber, Fritz R Murray, Dora Correia, Alessandra Bolsi, Martina Frei-Welte, Alessia Pica, Antony J Lomax, Ralf Schneider, Barbara Bachtiary
BACKGROUND: Few data exist regarding the clinical outcome of patients with Ewing sarcoma (EWS) treated with pencil beam scanning proton therapy (PT). We report the outcome of children, adolescents and young adults (AYA) treated with PT at the Paul Scherrer Institute. MATERIALS: Thirty-eight patients (median age, 9.9 years) received a median dose of 54.9 Gy(RBE) (where RBE is relative biologic effectiveness). Size of the tumor ranged from 1.7 to 24 cm. Most common primary site was axial/pelvic (n = 27; 71%)...
June 19, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28589845/deep-phylogeographic-breaks-in-magpie-pica-pica-across-the-holarctic-concordance-with-bioacoustics-and-phenotypes
#6
Alexey P Kryukov, Liudmila N Spiridonova, Sayaka Mori, Vladimir Yu Arkhipov, Yaroslav A Red'kin, Oleg A Goroshko, Evgeny G Lobkov, Elisabeth Haring
We examined sequences of the mitochondrial control region in magpies (Pica pica) from the entire distribution range and found deep genetic splits into four major lineages: (1) group West (Europe-Siberia), (2) group East (southern Far East), (3) P. p. mauritanica (North Africa), and (4) P. p. hudsonia (North America). These lineages show a geographic pattern corresponding to known subspecies or subspecies groups. Genetic variation within the widely-distributed group West is low and neutrality tests supported a recent expansion scenario...
June 2017: Zoological Science
https://www.readbyqxmd.com/read/28584917/morphometry-and-microsurgical-anatomy-of-bochdalek-s-flower-basket-and-the-related-structures-of-the-cerebellopontine-angle
#7
Laszlo Barany, Gabor Baksa, Lajos Patonay, Oliver Ganslandt, Michael Buchfelder, Peter Kurucz
BACKGROUND: Bochdalek's flower basket (Bfb) is the distal part of the horizontal segment of the fourth ventricle's choroid plexus protruding through the lateral aperture (foramen of Luschka). The microsurgical anatomy of the cerebellopontine angle, fourth ventricle and its inner choroid plexus is well described in the literature, but only one radiological study has investigated the Bfb so far. The goal of the present study was to give an extensive morphometric analysis of the Bfb for the first time and discuss the surgically relevant anatomical aspects...
June 6, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28583457/vertebrobasilar-insufficiency-due-to-distal-posterior-inferior-cerebellar-artery-compression-in-chiari-1-5
#8
M Burhan Janjua, Iryna Ivasyk, Jeffrey P Greenfield
Chiari malformation is characterized by radiographic evidence of herniation of cerebellar tonsils below the foramen magnum, and symptoms complex of headaches, breathing, swallowing or sleep difficulties, ataxia, restless, motor and/or sensory deficits. We report a case of a 34-year old female whose imaging indicated a Chiari 1.5 with brainstem (caudal medulla) herniation, and an expansive cervical syrinx. Her symptom complex showed signs both of cervical syringomyelia, as well as ones localizable to the medulla...
June 2, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28573564/effect-of-solid-waste-landfill-organic-pollutants-on-groundwater-in-three-areas-of-sicily-italy-characterized-by-different-vulnerability
#9
Serena Indelicato, Santino Orecchio, Giuseppe Avellone, Sergio Bellomo, Leopoldo Ceraulo, Rossella Di Leonardo, Vita Di Stefano, Rocco Favara, Esterina Gagliano Candela, Leonardo La Pica, Sabina Morici, Giovannella Pecoraino, Antonino Pisciotta, Claudio Scaletta, Fabio Vita, Salvatrice Vizzini, David Bongiorno
The aim of this study was to obtain information on the presence and levels of hazardous organic pollutants in groundwater located close to solid waste landfills. Eighty-two environmental contaminants, including 16 polycyclic aromatic hydrocarbons (PAHs), 20 volatile organic compounds (VOCs), 29 polychlorinated biphenyls (PCBs), 7 dioxins (polychlorinated dibenzo-p-dioxins, PCDDs) and 10 furans (polychlorinated dibenzofurans, PCDFs) were monitored in areas characterised by different geological environments surrounding three municipal solid waste landfills (Palermo, Siculiana and Ragusa) in Sicily (Italy) in three sampling campaigns...
June 1, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28567027/transient-vestibulopathy-in-wallenberg-s-syndrome-pathologic-analysis
#10
Jorge C Kattah, Ali S Saber Tehrani, Sigrun Roeber, Meena Gujrati, Sarah E Bach, David E Newman Toker, Ari M Blitz, Anja K E Horn
OBJECTIVE: To report an unusual lateral medullary stroke (LMS) associated with transient unidirectional horizontal, nystagmus, and decreased horizontal vestibulo-ocular reflex (h-VOR) gain that mimicked a peripheral vestibulopathy. MRI suggested involvement of caudal medial vestibular nucleus (MVN); however, the rapid resolution of the nystagmus and improved h-VOR gain favored transient ischemia without infarction. Decreased h-VOR gain is expected with peripheral vestibular lesions within the labyrinth or superior vestibular nerve; less frequently lateral pontine strokes involving the vestibular root entry, the vestibular fascicle, or neurons within the MVN may be responsible...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28566939/variation-of-a-persistent-primitive-hypoglossal-artery-ppha-as-incidental-finding-in-the-diagnostic-clarification-of-cerebral-vasculopathy-associated-with-intracranial-vasculitis
#11
S Hopf-Jensen, L Marques, M Preiß, W Börm, S Müller-Hülsbeck
We present a very rare variation of a persistent primitive hypoglossal artery (PPHA) arising from the internal carotid artery, detected during a diagnostic angiography. A 50-year-old female patient was admitted with an atypical intracranial hematoma in the left frontal lobe. Catheter angiography revealed intracranial vasculopathy with segmental stenoses, a small aneurysm of the right internal carotid artery bifurcation and a "string of beads" appearance of the left carotid artery, consistent with fibromuscular disease...
June 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28559079/respiratory-and-swallowing-outcomes-based-on-aneurysm-location-in-360-patients-with-subarachnoid-hemorrhage
#12
Isaac Josh Abecassis, Ryan P Morton, Lynn McGrath, Josiah Hanson, Anna H Xue, Cory M Kelly, Michael R Levitt, Laligam N Sekhar, Louis J Kim
INTRODUCTION: Aneurysmal subarachnoid hemorrhage (aSAH) may result in abnormal respiratory and swallowing function. We analyzed factors that may influence long-term respiratory and swallowing function in aSAH patients, and compared patients with anterior and posterior aneurysm locations. METHODS: We retrospectively reviewed 360 consecutive aSAH patients. We recorded location of the aneurysm and respiratory indices on admission, in-hospital adverse respiratory events and the need for tracheostomy (for respiratory failure) or percutaneous endoscopic gastrostomy (PEG) tube (for prolonged dysphagia)...
May 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28544848/decomposition-of-phenolic-impregnated-carbon-ablator-pica-as-a-function-of-temperature-and-heating-rate
#13
Brody K Bessire, Timothy K Minton
Material response models for phenolic-based thermal protection systems (TPSs) for atmospheric entry are limited by the lack of knowledge of the nonequilibrium processes that may govern the decomposition pathways of phenolic resin at heating rates up to tens of degrees Celsius per second. We have investigated the pyrolysis of phenolic impregnated carbon ablator (PICA) by measuring the molar yields of the volatile decomposition products as a function of temperature at four nominal heating rates of 3.1, 6.1, 12...
June 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28540133/lower-cranial-nerve-palsy-after-the-infrafloccular-approach-in-microvascular-decompression-for-hemifacial-spasm
#14
Kenichi Amagasaki, Nobuhiko Kurita, Saiko Watanabe, Naoyuki Shono, Atsushi Hosono, Kazuaki Naemura, Hiroshi Nakaguchi
BACKGROUND: The infrafloccular approach was introduced as a variation in microvascular decompression (MVD) for hemifacial spasm. However, the rate of postoperative lower cranial nerve (CN) palsy can be high. This study investigated the surgical factors in relation to the occurrence of postoperative lower CN palsy. METHODS: The case records of 103 patients who underwent MVD were reviewed. Dissection around the lower CNs to approach the root exit zone of CN VII was divided into two steps - incision of the rhomboid lip at the root of the lower CNs and separation of CN IX and flocculus/choroid plexus...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28536265/structural-and-enzymatic-insights-into-species-specific-resistance-to-schistosome-parasite-drug-therapy
#15
Alexander B Taylor, Kenneth M Roberts, Xiaohang Cao, Nathaniel E Clark, Stephen P Holloway, Enrica Donati, Chiara M Polcaro, Livia Pica-Mattoccia, Reid S Tarpley, Stanton F McHardy, Donato Cioli, Philip T LoVerde, Paul F Fitzpatrick, P John Hart
The antischistosomal pro-drug oxamniquine is activated by a sulfotransferase (SULT) in the human parasite Schistosoma mansoni Of the three main human blood fluke species, only S. mansoni is sensitive to oxamniquine therapy despite the presence of SULT orthologs in S. haematobium and S. japonicum The reason for this species-specific drug action has remained a mystery for decades. Here we present the crystal structures of S. haematobium and S. japonicum SULTs, including S. haematobium SULT in complex with oxamniquine...
May 23, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28521356/management-of-a-ruptured-posterior-inferior-cerebellar-artery-pica-aneurysm-with-pica-pica-in-situ-bypass-and-trapping-3-dimensional-operative-video
#16
Arnau Benet, Nicola Montemurro, Michael T Lawton
No abstract text is available yet for this article.
June 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28521350/surgical-treatment-of-a-double-origin-posterior-inferior-cerebellar-artery-aneurysm-and-insights-from-embryology-case-report-and-literature-review
#17
Michael A Silva, Alfred P See, Mohammad A Aziz-Sultan, Nirav J Patel
BACKGROUND AND IMPORTANCE: Aneurysms affecting double origin (DO) posterior inferior cerebellar artery (PICA) variants are rare. Most reports describe endovascular occlusion of the affected branch to treat the aneurysm, but we describe a patient in which open surgical sacrifice of 1 branch resulted in insufficient perfusion. CLINICAL PRESENTATION: We report the only case of open surgical treatment of an aneurysm affecting a leg of a DOPICA. A 42-year-old woman presenting with the worst headache of her life was found to have a DOPICA aneurysm and initially treated by trapping the aneurysm...
June 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28520943/risk-assessment-of-hemorrhage-of-posterior-inferior-cerebellar-artery-aneurysms-in-posterior-fossa-arteriovenous-malformations
#18
Alice L Hung, Wuyang Yang, Maria Braileanu, Tomas Garzon-Muvdi, Justin M Caplan, Geoffrey P Colby, Alexander L Coon, Rafael J Tamargo, Judy Huang
BACKGROUND: Posterior fossa arteriovenous malformations (AVMs) are associated with increased risk of rupture and severe consequences from such rupture. The hemorrhagic risk of prenidal aneurysms (anr) on the posterior inferior cerebellar artery (PICA) may exceed that of the AVM in posterior fossa AVMs fed by PICA (PICA-AVM). OBJECTIVE: To characterize the relative risks of aneurysm and AVM hemorrhage in patients with posterior fossa AVMs. METHODS: We retrospectively reviewed patients diagnosed with AVM...
May 18, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28510297/evaluation-of-the-safety-of-drugs-and-biological-products-used-during-lactation-workshop-summary
#19
REVIEW
J Wang, T Johnson, L Sahin, M S Tassinari, P O Anderson, T E Baker, C Bucci-Rechtweg, G J Burckart, C D Chambers, T W Hale, D Johnson-Lyles, R M Nelson, C Nguyen, D Pica-Branco, Z Ren, H Sachs, J Sauberan, A Zajicek, S Ito, L P Yao
This report serves as a summary of a 2-day public workshop sponsored by the US Food and Drug Administration (FDA) to discuss the safety of drugs and biological products used during lactation. The aim of the workshop was to provide a forum to discuss the collection of data to inform the potential risks to breastfed infants with maternal use of medications during lactation. Discussions included the review of current approaches to collect data on medications used during lactation, and the considerations for future approaches to design and guide clinical lactation studies...
June 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28509666/an-inhibitory-gate-for-state-transition-in-cortex
#20
Stefano Zucca, Giulia D'Urso, Valentina Pasquale, Dania Vecchia, Giuseppe Pica, Serena Bovetti, Claudio Moretti, Stefano Varani, Manuel Molano-Mazón, Michela Chiappalone, Stefano Panzeri, Tommaso Fellin
Large scale transitions between active (up) and silent (down) states during quiet wakefulness or NREM sleep regulate fundamental cortical functions and are known to involve both excitatory and inhibitory cells. However, if and how inhibition regulates these activity transitions is unclear. Using fluorescence-targeted electrophysiological recording and cell-specific optogenetic manipulation in both anesthetized and non-anesthetized mice, we found that two major classes of interneurons, the parvalbumin and the somatostatin positive cells, tightly control both up-to-down and down-to-up state transitions...
May 16, 2017: ELife
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